                         SEQUENCE LISTING

<110>  iCell Gene Therapeutics LLC
 
<120>  Chimeric Antigen Receptors (CARs), Compositions and 
       Methods of Use

<130>  2541-3 PCT

<140>  0000000
<141>  2016-06-24

<150>  62/184,321
<151>  2015-06-25

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  830
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Tyr Ser Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
65                  70                  75                  80  


Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly 
            180                 185                 190         


Leu Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr 
        195                 200                 205             


Asp Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp 
                245                 250                 255     


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
    530                 535                 540                 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Tyr Arg 
545                 550                 555                 560 


Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val Thr Asn 
                565                 570                 575     


Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro 
            580                 585                 590         


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
        595                 600                 605             


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
    610                 615                 620                 


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
625                 630                 635                 640 


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
                645                 650                 655     


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
            660                 665                 670         


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
        675                 680                 685             


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
    690                 695                 700                 


Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
                725                 730                 735     


Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala Leu 
            740                 745                 750         


Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr Cys 
        755                 760                 765             


Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr 
    770                 775                 780                 


Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr 
                805                 810                 815     


Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
            820                 825                 830 


<210>  2
<211>  2509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  2
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg atgacccaaa gccccgacag cctggccgtg agcctgggcg      120

agagggtgac catgaactgc aaaagcagcc agtccctgct gtactccacc aaccagaaga      180

actacctggc ttggtatcaa cagaagcccg gacagagccc caagctgctg atctattggg      240

ccagcactag ggaaagcggc gtgcccgata ggttcagcgg cagcgggagc ggcacagact      300

tcactctgac cattagcagc gtgcaggctg aggatgtggc cgtctactac tgccagcagt      360

actacagcta caggaccttt gggggcggaa ctaagctgga gatcaaggga ggggggggat      420

ccgggggagg aggctccggc ggaggcggaa gccaagtgca actgcagcag agcggcccag      480

aggtggtcaa acctggggca agcgtgaaga tgagctgcaa ggctagcggc tataccttca      540

ccagctatgt gatccactgg gtgaggcaga aaccaggaca gggcctggac tggatcggct      600

acatcaaccc ctacaatgac ggcaccgatt atgacgaaaa attcaagggg aaggccaccc      660

tgaccagcga caccagcaca agcaccgcct acatggagct gtccagcctg aggtccgagg      720

acaccgccgt gtattactgt gccagggaga aggacaatta cgccaccggc gcttggttcg      780

cctactgggg ccagggcaca ctggtgacag tgagcagcac cacgacgcca gcgccgcgac      840

caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc      900

ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt gatatctaca      960

tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt atcacccttt     1020

actgcaggag taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc     1080

gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct     1140

atcgctccaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac     1200

cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag     1260

gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     1320

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     1380

acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg aagaaccctc     1440

aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg     1500

ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta     1560

cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgcggaagcg     1620

gagccaccaa cttcagcctg ctgaagcagg ccggcgacgt ggaggagaac cccggcccca     1680

tgtacagaat gcagctgctg agctgcatcg ccctgagcct ggccctggtg accaacagcg     1740

gcatccacgt gttcatcctg ggctgcttca gcgccggcct gcccaagacc gaggccaact     1800

gggtgaacgt gatcagcgac ctgaagaaga tcgaggacct gatccagagc atgcacatcg     1860

acgccaccct gtacaccgag agcgacgtgc accccagctg caaggtgacc gccatgaagt     1920

gcttcctgct ggagctgcag gtgatcagcc tggagagcgg cgacgccagc atccacgaca     1980

ccgtggagaa cctgatcatc ctggccaaca acagcctgag cagcaacggc aacgtgaccg     2040

agagcggctg caaggagtgc gaggagctgg aggagaagaa catcaaggag ttcctgcaga     2100

gcttcgtgca catcgtgcag atgttcatca acaccagctc cggcggcggc tccggcggcg     2160

gcggctccgg cggcggcggc tccggcggcg gcggctccgg cggcggctcc ctgcaggccc     2220

ccagaagagc cagaggctgc agaaccctgg gcctgcccgc cctgctgctg ctgctgctgc     2280

tgagaccccc cgccaccaga ggcatcacct gccccccccc catgagcgtg gagcacgccg     2340

acatctgggt gaagagctac agcctgtaca gcagagagag atacatctgc aacagcggct     2400

tcaagagaaa ggccggcacc agcagcctga ccgagtgcgt gctgaacaag gccaccaacg     2460

tggcccactg gaccaccccc agcctgaagt gcatcagata agtttaaac                 2509


<210>  3
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser 
    530                 535                 540                 


Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser 
545                 550                 555                 560 


Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp 
                565                 570                 575     


Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
            580                 585                 590         


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu 
        595                 600                 605             


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro 
    610                 615                 620                 


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
                645                 650                 655     


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
            660                 665                 670         


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val 
        675                 680                 685             


Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
    690                 695                 700                 


Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr 
705                 710                 715                 720 


Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
                725                 730                 735     


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Thr Tyr 
            740                 745                 750         


Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly Thr Thr Val 
        755                 760                 765             


Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    770                 775                 780                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
785                 790                 795                 800 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                805                 810                 815     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            820                 825                 830         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu 
        835                 840                 845             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    850                 855                 860                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
865                 870                 875                 880 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                885                 890                 895     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            900                 905                 910         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        915                 920                 925             


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    930                 935                 940                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
945                 950                 955                 960 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                965                 970                 975     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            980                 985                 990         


Pro Pro Arg 
        995 


<210>  4
<211>  3004
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatccag atgacacaga ctacatcctc cctgtctgcc tctctgggag      120

acagagtcac catcagttgc agggcaagtc aggacattag taaatattta aattggtatc      180

agcagaaacc agatggaact gttaaactcc tgatctacca tacatcaaga ttacactcag      240

gagtcccatc aaggttcagt ggcagtgggt ctggaacaga ttattctctc accattagca      300

acctggagca agaagatatt gccacttact tttgccaaca gggtaatacg cttccgtaca      360

cgttcggagg ggggaccaag ctggagatca caggtggcgg tggctcgggc ggtggtgggt      420

cgggtggcgg cggatctgag gtgaaactgc aggagtcagg acctggcctg gtggcgccct      480

cacagagcct gtccgtcaca tgcactgtct caggggtctc attacccgac tatggtgtaa      540

gctggattcg ccagcctcca cgaaagggtc tggagtggct gggagtaata tggggtagtg      600

aaaccacata ctataattca gctctcaaat ccagactgac catcatcaag gacaactcca      660

agagccaagt tttcttaaaa atgaacagtc tgcaaactga tgacacagcc atttactact      720

gtgccaaaca ttattactac ggtggtagct atgctatgga ctactggggc caaggaacct      780

cagtcaccgt ctcctcaacc acgacgccag cgccgcgacc accaacaccg gcgcccacca      840

tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag      900

tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga      960

cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg ggcagaaaga     1020

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     1080

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gaagcggagc caccaacttc agcctgctga     1500

agcaggccgg cgacgtggag gagaaccccg gccccatggc cttaccagtg accgccttgc     1560

tcctgccgct ggccttgctg ctccacgccg ccaggccgca gatcgtgctg agccagagcc     1620

ctgccatcct gtccgcaagc ccaggcgaga aggtgaccat gacctgtagg gccagcagct     1680

ccgtgagcta catccactgg tttcagcaga agcctggaag cagccctaag ccctggatct     1740

acgccacaag caatctggct agcggcgtgc ccgtgaggtt cagcggcagc gggagcggga     1800

ccagctacag cctgactatc agcagggtgg aggccgagga cgccgccaca tactactgcc     1860

aacagtggac ctccaaccca cccacctttg gaggagggac aaaactggag atcaaagggg     1920

gcggagggtc cggaggcggc ggaagcgggg gagggggaag ccaggtccaa ctgcaacagc     1980

ccggagcaga actggtcaaa ccaggcgcca gcgtgaagat gagctgcaag gccagcgggt     2040

acaccttcac ttcctataac atgcactggg tgaagcagac cccaggaagg ggcctggagt     2100

ggatcggggc aatctatccc ggcaacggcg acacaagcta caaccagaag ttcaagggga     2160

aagccactct gaccgccgac aagtccagct ccaccgccta catgcagctg agctccctga     2220

ccagcgagga cagcgccgtg tactattgcg ccagaagcac ttattacgga ggggactggt     2280

acttcaacgt gtggggggca gggaccaccg tgaccgtgtc cgccaccacg acgccagcgc     2340

cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg     2400

cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata     2460

tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca     2520

ccctttactg caggagtaag aggagcaggc tcctgcacag tgactacatg aacatgactc     2580

cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca cgcgacttcg     2640

cagcctatcg ctccagagtg aagttcagca ggagcgcaga cgcccccgcg taccagcagg     2700

gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg     2760

acaagagacg tggccgggac cctgagatgg ggggaaagcc gcagagaagg aagaaccctc     2820

aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg     2880

ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta     2940

cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaagttt     3000

aaac                                                                  3004


<210>  5
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  5

Asp Arg Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
                165                 170                 175     


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
                485                 490                 495     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
            500                 505                 510         


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
        515                 520                 525             


Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    530                 535                 540                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile 
545                 550                 555                 560 


Val His Ser Val Gly Asn Thr Phe Leu Glu Trp Tyr Gln Gln Lys Pro 
                565                 570                 575     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
            580                 585                 590         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        595                 600                 605             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    610                 615                 620                 


Phe Gln Gly Ser Gln Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val 
625                 630                 635                 640 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                645                 650                 655     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            660                 665                 670         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Glu Phe Ser 
        675                 680                 685             


Arg Ser Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    690                 695                 700                 


Trp Val Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ser Gly 
705                 710                 715                 720 


Lys Phe Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
                725                 730                 735     


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            740                 745                 750         


Tyr Cys Ala Arg Asp Gly Ser Ser Trp Asp Trp Tyr Phe Asp Val Trp 
        755                 760                 765             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
    770                 775                 780                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
785                 790                 795                 800 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                805                 810                 815     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            820                 825                 830         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        835                 840                 845             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    850                 855                 860                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
865                 870                 875                 880 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                885                 890                 895     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            900                 905                 910         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        915                 920                 925             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    930                 935                 940                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
945                 950                 955                 960 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                965                 970                 975     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            980                 985                 990         


Leu His Met Gln Ala Leu Pro Pro  Arg 
        995                 1000     


<210>  6
<211>  3016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  6
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatccag atgacacaga ctacatcctc cctgtctgcc tctctgggag      120

acagagtcac catcagttgc agggcaagtc aggacattag taaatattta aattggtatc      180

agcagaaacc agatggaact gttaaactcc tgatctacca tacatcaaga ttacactcag      240

gagtcccatc aaggttcagt ggcagtgggt ctggaacaga ttattctctc accattagca      300

acctggagca agaagatatt gccacttact tttgccaaca gggtaatacg cttccgtaca      360

cgttcggagg ggggaccaag ctggagatca caggtggcgg tggctcgggc ggtggtgggt      420

cgggtggcgg cggatctgag gtgaaactgc aggagtcagg acctggcctg gtggcgccct      480

cacagagcct gtccgtcaca tgcactgtct caggggtctc attacccgac tatggtgtaa      540

gctggattcg ccagcctcca cgaaagggtc tggagtggct gggagtaata tggggtagtg      600

aaaccacata ctataattca gctctcaaat ccagactgac catcatcaag gacaactcca      660

agagccaagt tttcttaaaa atgaacagtc tgcaaactga tgacacagcc atttactact      720

gtgccaaaca ttattactac ggtggtagct atgctatgga ctactggggc caaggaacct      780

cagtcaccgt ctcctcaacc acgacgccag cgccgcgacc accaacaccg gcgcccacca      840

tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag      900

tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga      960

cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg ggcagaaaga     1020

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     1080

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga     1320

aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca     1380

aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc     1440

ttcacatgca ggccctgccc cctcgcggaa gcggagccac caacttcagc ctgctgaagc     1500

aggccggcga cgtggaggag aaccccggcc ccatggcctt accagtgacc gccttgctcc     1560

tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccca     1620

gctccctgtc cgcatccgtg ggcgacagag tgacaattac ctgtagaagc agccaaagca     1680

tcgtgcatag cgtcggcaac acttttctgg agtggtatca acagaagccc gggaaggccc     1740

ccaaactgct gatctacaag gtgagcaaca gattcagcgg ggtcccaagc agattctccg     1800

gcagcggctc cgggactgac ttcaccctga ccattagcag cctgcagcca gaggacttcg     1860

ccacatacta ctgcttccaa gggagccagt tcccctacac cttcggccaa ggcactaagg     1920

tggagatcaa agggggggga ggaagcggcg gaggagggag cggaggcggg ggatccgaag     1980

tgcaactggt cgaatccgga ggggggctgg tccagcctgg agggtccctg agactgagct     2040

gcgccgcaag cggctacgag ttctccaggt cctggatgaa ctgggtgagg caggccccag     2100

gaaaagggct ggaatgggtg ggcaggatct accctggcga cggcgatacc aactactccg     2160

gaaagttcaa gggcaggttc actatcagcg ccgacactag caagaatacc gcctacctgc     2220

agatgaatag cctgagggcc gaggacaccg ccgtgtatta ctgcgctaga gacggcagca     2280

gctgggattg gtacttcgac gtgtggggcc agggcactct ggtgactgtg agcagcacca     2340

cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc     2400

tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg gggctggact     2460

tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc cttctcctgt     2520

cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat atattcaaac     2580

aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc tgccgatttc     2640

cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc gcagacgccc     2700

ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga cgaagagagg     2760

agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga aagccgagaa     2820

ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg gcggaggcct     2880

acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc     2940

agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag gccctgcccc     3000

ctcgctaagt ttaaac                                                     3016


<210>  7
<211>  990
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    530                 535                 540                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
545                 550                 555                 560 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                565                 570                 575     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            580                 585                 590         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        595                 600                 605             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    610                 615                 620                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
                645                 650                 655     


Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu 
            660                 665                 670         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp 
        675                 680                 685             


Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp 
    690                 695                 700                 


Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala 
705                 710                 715                 720 


Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser 
                725                 730                 735     


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn 
            740                 745                 750         


Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr 
        755                 760                 765             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    770                 775                 780                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
785                 790                 795                 800 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                805                 810                 815     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            820                 825                 830         


Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        835                 840                 845             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    850                 855                 860                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
865                 870                 875                 880 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                885                 890                 895     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            900                 905                 910         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
        915                 920                 925             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    930                 935                 940                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
945                 950                 955                 960 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                965                 970                 975     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            980                 985                 990 


<210>  8
<211>  2989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatccag atgacacaga ctacatcctc cctgtctgcc tctctgggag      120

acagagtcac catcagttgc agggcaagtc aggacattag taaatattta aattggtatc      180

agcagaaacc agatggaact gttaaactcc tgatctacca tacatcaaga ttacactcag      240

gagtcccatc aaggttcagt ggcagtgggt ctggaacaga ttattctctc accattagca      300

acctggagca agaagatatt gccacttact tttgccaaca gggtaatacg cttccgtaca      360

cgttcggagg ggggaccaag ctggagatca caggtggcgg tggctcgggc ggtggtgggt      420

cgggtggcgg cggatctgag gtgaaactgc aggagtcagg acctggcctg gtggcgccct      480

cacagagcct gtccgtcaca tgcactgtct caggggtctc attacccgac tatggtgtaa      540

gctggattcg ccagcctcca cgaaagggtc tggagtggct gggagtaata tggggtagtg      600

aaaccacata ctataattca gctctcaaat ccagactgac catcatcaag gacaactcca      660

agagccaagt tttcttaaaa atgaacagtc tgcaaactga tgacacagcc atttactact      720

gtgccaaaca ttattactac ggtggtagct atgctatgga ctactggggc caaggaacct      780

cagtcaccgt ctcctcaacc acgacgccag cgccgcgacc accaacaccg gcgcccacca      840

tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag      900

tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga      960

cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg ggcagaaaga     1020

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     1080

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt     1140

tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc tataacgagc     1200

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     1260

agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac aatgaactgc     1320

agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag cgccggaggg     1380

gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac acctacgacg     1440

cccttcacat gcaggccctg ccccctcgcg gaagcggagc caccaacttc agcctgctga     1500

agcaggccgg cgacgtggag gagaaccccg gccccatggc cttaccagtg accgccttgc     1560

tcctgccgct ggccttgctg ctccacgccg ccaggccgga cgtgcagatc acccagagcc     1620

ccagctacct ggccgccagc cccggcgaga ccatcaccat caactgcaga gccagcaaga     1680

gcatcagcaa ggacctggcc tggtaccagg agaagcccgg caagaccaac aagctgctga     1740

tctacagcgg cagcaccctg cagagcggca tccccagcag attcagcggc agcggcagcg     1800

gcaccgactt caccctgacc atcagcagcc tggagcccga ggacttcgcc atgtactact     1860

gccagcagca caacaagtac ccctacacct tcggcggcgg caccaagctg gagatcaagg     1920

gagggggggg atccggggga ggaggctccg gcggaggcgg aagccaggtg cagctgcagc     1980

agcccggcgc cgagctggtg agacccggcg ccagcgtgaa gctgagctgc aaggccagcg     2040

gctacacctt caccagctac tggatgaact gggtgaagca gagacccgac cagggcctgg     2100

agtggatcgg cagaatcgac ccctacgaca gcgagaccca ctacaaccag aagttcaagg     2160

acaaggccat cctgaccgtg gacaagagca gcagcaccgc ctacatgcag ctgagcagcc     2220

tgaccagcga ggacagcgcc gtgtactact gcgccagagg caactgggac gactactggg     2280

gccagggcac caccctgacc gtgagcagca ccacgacgcc agcgccgcga ccaccaacac     2340

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg     2400

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc     2460

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga     2520

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     2580

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     2640

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct     2700

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     2760

gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca     2820

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     2880

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     2940

cctacgacgc ccttcacatg caggccctgc cccctcgcta agtttaaac                 2989


<210>  9
<211>  1066
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Ile Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Leu Trp Ile Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser 
            100                 105                 110         


Thr Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Arg Met 
                165                 170                 175     


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
                325                 330                 335     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            340                 345                 350         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        355                 360                 365             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    370                 375                 380                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                405                 410                 415     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            420                 425                 430         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        435                 440                 445             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    450                 455                 460                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
465                 470                 475                 480 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                485                 490                 495     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            500                 505                 510         


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
        515                 520                 525             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    530                 535                 540                 


Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
545                 550                 555                 560 


His Ala Ala Arg Pro Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu 
                565                 570                 575     


Ala Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys 
            580                 585                 590         


Ser Ile Ser Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr 
        595                 600                 605             


Asn Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro 
    610                 615                 620                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
625                 630                 635                 640 


Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His 
                645                 650                 655     


Asn Lys Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        675                 680                 685             


Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser 
    690                 695                 700                 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
705                 710                 715                 720 


Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile Gly 
                725                 730                 735     


Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
            740                 745                 750         


Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        755                 760                 765             


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    770                 775                 780                 


Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
785                 790                 795                 800 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                805                 810                 815     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            820                 825                 830         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        835                 840                 845             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    850                 855                 860                 


Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His 
865                 870                 875                 880 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                885                 890                 895     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            900                 905                 910         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        915                 920                 925             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    930                 935                 940                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
945                 950                 955                 960 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
                965                 970                 975     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            980                 985                 990         


Arg Gly Arg Asp Pro Glu Met Gly  Gly Lys Pro Arg Arg  Lys Asn Pro 
        995                 1000                 1005             


Gln Glu  Gly Leu Tyr Asn Glu  Leu Gln Lys Asp Lys  Met Ala Glu 
    1010                 1015                 1020             


Ala Tyr  Ser Glu Ile Gly Met  Lys Gly Glu Arg Arg  Arg Gly Lys 
    1025                 1030                 1035             


Gly His  Asp Gly Leu Tyr Gln  Gly Leu Ser Thr Ala  Thr Lys Asp 
    1040                 1045                 1050             


Thr Tyr  Asp Ala Leu His Met  Gln Ala Leu Pro Pro  Arg 
    1055                 1060                 1065     


<210>  10
<211>  3217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gcagatcgtg ctgacccaga gccccgccat catgagcgcc agccccggcg      120

agaaggtgac catcacctgc agcgccagca gcagcatcag ctacatgcac tggttccagc      180

agaagcccgg caccagcccc aagctgtgga tctacaccac cagcaacctg gccagcggcg      240

tgcccgccag attcagcggc agcggcagcg gcaccagcta cagcctgacc atcagcagaa      300

tggaggccga ggacgccgcc acctactact gccaccagag aagcacctac cccctgacct      360

tcggcagcgg caccaagctg gagctgaagg gagggggggg atccggggga ggaggctccg      420

gcggaggcgg aagccaggtg cagctgcagc agagcggcgc cgagctggcc aagcccggcg      480

ccagcgtgaa gatgagctgc aaggccagcg gctacacctt caccagctac agaatgcact      540

gggtgaagca gagacccggc cagggcctgg agtggatcgg ctacatcaac cccagcaccg      600

gctacaccga gtacaaccag aagttcaagg acaaggccac cctgaccgcc gacaagagca      660

gcagcaccgc ctacatgcag ctgagcagcc tgaccttcga ggacagcgcc gtgtactact      720

gcgccagagg cggcggcgtg ttcgactact ggggccaggg caccaccctg accgtgagca      780

gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc      840

tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac acgagggggc      900

tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt ggggtccttc      960

tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc ctgcacagtg     1020

actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac cagccctatg     1080

ccccaccacg cgacttcgca gcctatcgct ccaaacgggg cagaaagaaa ctcctgtata     1140

tattcaaaca accatttatg agaccagtac aaactactca agaggaagat ggctgtagct     1200

gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc agcaggagcg     1260

cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc aatctaggac     1320

gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag atggggggaa     1380

agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg     1440

cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg     1500

gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg     1560

ccctgccccc tcgcggaagc ggagctacta acttcagcct gctgaagcag gctggagacg     1620

tggaggagaa ccctggacct atggccttac cagtgaccgc cttgctcctg ccgctggcct     1680

tgctgctcca cgccgccagg ccggacgtgc agatcaccca gagccccagc tacctggccg     1740

ccagccccgg cgagaccatc accatcaact gcagagccag caagagcatc agcaaggacc     1800

tggcctggta ccaggagaag cccggcaaga ccaacaagct gctgatctac agcggcagca     1860

ccctgcagag cggcatcccc agcagattca gcggcagcgg cagcggcacc gacttcaccc     1920

tgaccatcag cagcctggag cccgaggact tcgccatgta ctactgccag cagcacaaca     1980

agtaccccta caccttcggc ggcggcacca agctggagat caagggaggg gggggatccg     2040

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct gcagcagccc ggcgccgagc     2100

tggtgagacc cggcgccagc gtgaagctga gctgcaaggc cagcggctac accttcacca     2160

gctactggat gaactgggtg aagcagagac ccgaccaggg cctggagtgg atcggcagaa     2220

tcgaccccta cgacagcgag acccactaca accagaagtt caaggacaag gccatcctga     2280

ccgtggacaa gagcagcagc accgcctaca tgcagctgag cagcctgacc agcgaggaca     2340

gcgccgtgta ctactgcgcc agaggcaact gggacgacta ctggggccag ggcaccaccc     2400

tgaccgtgag cagcaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     2460

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     2520

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     2580

gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag aggagcaggc     2640

tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc cgcaagcatt     2700

accagcccta tgccccacca cgcgacttcg cagcctatcg ctccaaacgg ggcagaaaga     2760

aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag     2820

atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt     2880

tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc tataacgagc     2940

tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc cgggaccctg     3000

agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga     3060

aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca     3120

aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc     3180

ttcacatgca ggccctgccc cctcgctaag tttaaac                              3217


<210>  11
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Ile Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Leu Trp Ile Tyr Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser 
            100                 105                 110         


Thr Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Arg Met 
                165                 170                 175     


His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp 
        195                 200                 205             


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu 
            500                 505                 510         


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Val Gln 
        515                 520                 525             


Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly Glu Thr Ile 
    530                 535                 540                 


Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp Leu Ala Trp 
545                 550                 555                 560 


Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr Ser Gly 
                565                 570                 575     


Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            580                 585                 590         


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
        595                 600                 605             


Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr Thr Phe Gly 
    610                 615                 620                 


Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
                645                 650                 655     


Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
            660                 665                 670         


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
        675                 680                 685             


Asp Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu 
    690                 695                 700                 


Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp 
705                 710                 715                 720 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
                725                 730                 735     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Asn Trp Asp Asp Tyr Trp 
            740                 745                 750         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        755                 760                 765             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    770                 775                 780                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
785                 790                 795                 800 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                805                 810                 815     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
            820                 825                 830         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        835                 840                 845             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    850                 855                 860                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
865                 870                 875                 880 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                885                 890                 895     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            900                 905                 910         


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
        915                 920                 925             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    930                 935                 940                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
945                 950                 955                 960 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                965                 970                 975     


Leu His Met Gln Ala Leu Pro Pro Arg 
            980                 985 


<210>  12
<211>  2974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  12
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gcagatcgtg ctgacccaga gccccgccat catgagcgcc agccccggcg      120

agaaggtgac catcacctgc agcgccagca gcagcatcag ctacatgcac tggttccagc      180

agaagcccgg caccagcccc aagctgtgga tctacaccac cagcaacctg gccagcggcg      240

tgcccgccag attcagcggc agcggcagcg gcaccagcta cagcctgacc atcagcagaa      300

tggaggccga ggacgccgcc acctactact gccaccagag aagcacctac cccctgacct      360

tcggcagcgg caccaagctg gagctgaagg gagggggggg atccggggga ggaggctccg      420

gcggaggcgg aagccaggtg cagctgcagc agagcggcgc cgagctggcc aagcccggcg      480

ccagcgtgaa gatgagctgc aaggccagcg gctacacctt caccagctac agaatgcact      540

gggtgaagca gagacccggc cagggcctgg agtggatcgg ctacatcaac cccagcaccg      600

gctacaccga gtacaaccag aagttcaagg acaaggccac cctgaccgcc gacaagagca      660

gcagcaccgc ctacatgcag ctgagcagcc tgaccttcga ggacagcgcc gtgtactact      720

gcgccagagg cggcggcgtg ttcgactact ggggccaggg caccaccctg accgtgagca      780

gcaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc      840

tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac acgagggggc      900

tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt ggggtccttc      960

tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc ctgtatatat     1020

tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc     1080

gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc aggagcgcag     1140

acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat ctaggacgaa     1200

gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg gggggaaagc     1260

cgcagagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa gataagatgg     1320

cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag gggcacgatg     1380

gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt cacatgcagg     1440

ccctgccccc tcgcggaagc ggagctacta acttcagcct gctgaagcag gctggagacg     1500

tggaggagaa ccctggacct atggccttac cagtgaccgc cttgctcctg ccgctggcct     1560

tgctgctcca cgccgccagg ccggacgtgc agatcaccca gagccccagc tacctggccg     1620

ccagccccgg cgagaccatc accatcaact gcagagccag caagagcatc agcaaggacc     1680

tggcctggta ccaggagaag cccggcaaga ccaacaagct gctgatctac agcggcagca     1740

ccctgcagag cggcatcccc agcagattca gcggcagcgg cagcggcacc gacttcaccc     1800

tgaccatcag cagcctggag cccgaggact tcgccatgta ctactgccag cagcacaaca     1860

agtaccccta caccttcggc ggcggcacca agctggagat caagggaggg gggggatccg     1920

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct gcagcagccc ggcgccgagc     1980

tggtgagacc cggcgccagc gtgaagctga gctgcaaggc cagcggctac accttcacca     2040

gctactggat gaactgggtg aagcagagac ccgaccaggg cctggagtgg atcggcagaa     2100

tcgaccccta cgacagcgag acccactaca accagaagtt caaggacaag gccatcctga     2160

ccgtggacaa gagcagcagc accgcctaca tgcagctgag cagcctgacc agcgaggaca     2220

gcgccgtgta ctactgcgcc agaggcaact gggacgacta ctggggccag ggcaccaccc     2280

tgaccgtgag cagcaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg     2340

cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc     2400

acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg gccgggactt     2460

gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag aggagcaggc     2520

tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc cgcaagcatt     2580

accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg aagttcagca     2640

ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac gagctcaatc     2700

taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac cctgagatgg     2760

ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag     2820

ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg aggggcaagg     2880

ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac gacgcccttc     2940

acatgcaggc cctgccccct cgctaagttt aaac                                 2974


<210>  13
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
65                  70                  75                  80  


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Lys Ile Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg 
            180                 185                 190         


Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        195                 200                 205             


Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr Pro Ser 
    210                 215                 220                 


Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
225                 230                 235                 240 


Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr 
                245                 250                 255     


Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
            340                 345                 350         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        355                 360                 365             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    370                 375                 380                 


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
385                 390                 395                 400 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                405                 410                 415     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            420                 425                 430         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        435                 440                 445             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    450                 455                 460                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
465                 470                 475                 480 


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                485                 490                 495     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            500                 505                 510         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        515                 520                 525             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    530                 535                 540                 


Pro Arg 
545     


<210>  14
<211>  1657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  14
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc gagcgacatc gtgctgaccc agagccccgc cagcctggcc gtgagcctgg      120

gccagagagc caccatcagc tgcagagcca gcaagagcgt gagcaccagc ggctacagct      180

acctgcactg gtaccagcag aagcccggcc agccccccaa gctgctgatc tacctggcca      240

gcaacctgga gagcggcgtg cccgccagat tcagcggcag cggcagcggc accgacttca      300

ccctgaacat ccaccccgtg gaggaggagg acgccgccac ctactactgc cagcacagca      360

gagagctgcc cttcaccttc ggcagcggca ccaagctgga gatcaagaag atcagcggcg      420

gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cggcggcggc ggcagcggcg      480

gcggcggcag ccaggtgcag ctggtggaga gcggcggcgg cctggtgcag cccggcggca      540

gcctgaagct gagctgcgcc gccagcggct tcgacttcag cagatactgg atgagctggg      600

tgagacaggc ccccggcaag ggcctggagt ggatcggcga gatcaacccc accagcagca      660

ccatcaactt cacccccagc ctgaaggaca aggtgttcat cagcagagac aacgccaaga      720

acaccctgta cctgcagatg agcaaggtga gaagcgagga caccgccctg tactactgcg      780

ccagaggcaa ctactacaga tacggcgacg ccatggacta ctggggccag ggcaccagcg      840

tgaccgtgag caccacgacg ccagcgccgc gaccaccaac accggcgccc accatcgcgt      900

cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc gcagtgcaca      960

cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc gggacttgtg     1020

gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg agcaggctcc     1080

tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc aagcattacc     1140

agccctatgc cccaccacgc gacttcgcag cctatcgctc caaacggggc agaaagaaac     1200

tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa gaggaagatg     1260

gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga gtgaagttca     1320

gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat aacgagctca     1380

atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg gaccctgaga     1440

tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga     1500

aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca     1560

aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc     1620

ttcacatgca ggccctgccc cctcgctaag tttaaac                              1657


<210>  15
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  16
<211>  1489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  16
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg ctgacccaga gccccgccag cctggccgtg agcctgggcc      120

agagggccac catcagctgc agggccagca agagcgtgag caccagcggc tacagctacc      180

tgcactggta ccagcagaag cccggccagc cccccaagct gctgatctac ctggccagca      240

acctggagag cggcgtgccc gccaggttca gcggcagcgg cagcggcacc gacttcaccc      300

tgaacatcca ccccgtggag gaggaggacg ccgccaccta ctactgccag cacagcaggg      360

agctgccctt caccttcggc agcggcacca agctggagat caagggaggg gggggatccg      420

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct ggtggagagc ggcggcggcc      480

tggtgcagcc cggcggcagc ctgaagctga gctgcgccgc cagcggcttc gacttcagca      540

ggtactggat gagctgggtg aggcaggccc ccggcaaggg cctggagtgg atcggcgaga      600

tcaaccccac cagcagcacc atcaacttca cccccagcct gaaggacaag gtgttcatca      660

gcagggacaa cgccaagaac accctgtacc tgcagatgag caaggtgagg agcgaggaca      720

ccgccctgta ctactgcgcc aggggcaact actacaggta cggcgacgcc atggactact      780

ggggccaggg caccagcgtg accgtgagca ccacgacgcc agcgccgcga ccaccaacac      840

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      900

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      960

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcagga     1020

gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc cgccccgggc     1080

ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc tatcgctcca     1140

gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca gcagggccag aaccagctct     1200

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc     1260

gggaccctga gatgggggga aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca     1320

atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg aaaggcgagc     1380

gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc accaaggaca     1440

cctacgacgc ccttcacatg caggccctgc cccctcgcta agtttaaac                 1489


<210>  17
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys 
        35                  40                  45              


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe 
                165                 170                 175     


Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe Thr 
        195                 200                 205             


Pro Ser Leu Lys Asp Lys Val Phe Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  18
<211>  1492
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  18
gcgatcgcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg       60

ccgccaggcc ggacatcgtg ctgacccaga gccccgccag cctggccgtg agcctgggcc      120

agagggccac catcagctgc agggccagca agagcgtgag caccagcggc tacagctacc      180

tgcactggta ccagcagaag cccggccagc cccccaagct gctgatctac ctggccagca      240

acctggagag cggcgtgccc gccaggttca gcggcagcgg cagcggcacc gacttcaccc      300

tgaacatcca ccccgtggag gaggaggacg ccgccaccta ctactgccag cacagcaggg      360

agctgccctt caccttcggc agcggcacca agctggagat caagggaggg gggggatccg      420

ggggaggagg ctccggcgga ggcggaagcc aggtgcagct ggtggagagc ggcggcggcc      480

tggtgcagcc cggcggcagc ctgaagctga gctgcgccgc cagcggcttc gacttcagca      540

ggtactggat gagctgggtg aggcaggccc ccggcaaggg cctggagtgg atcggcgaga      600

tcaaccccac cagcagcacc atcaacttca cccccagcct gaaggacaag gtgttcatca      660

gcagggacaa cgccaagaac accctgtacc tgcagatgag caaggtgagg agcgaggaca      720

ccgccctgta ctactgcgcc aggggcaact actacaggta cggcgacgcc atggactact      780

ggggccaggg caccagcgtg accgtgagca ccacgacgcc agcgccgcga ccaccaacac      840

cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg      900

cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac atctgggcgc      960

ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt tactgcaaac     1020

ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca gtacaaacta     1080

ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga ggatgtgaac     1140

tgagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc cagaaccagc     1200

tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac aagagacgtg     1260

gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag gaaggcctgt     1320

acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg     1380

agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg     1440

acacctacga cgcccttcac atgcaggccc tgccccctcg ctaagtttaa ac             1492


<210>  19
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Thr Arg Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp 
        195                 200                 205             


Phe Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
                485                 490                 495     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            500                 505                 510         


Pro Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
        515                 520                 525             


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    530                 535                 540                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
545                 550                 555                 560 


Asp Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
                565                 570                 575     


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
            580                 585                 590         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        595                 600                 605             


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    610                 615                 620                 


Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
                645                 650                 655     


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            660                 665                 670         


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr Trp 
        675                 680                 685             


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    690                 695                 700                 


Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
705                 710                 715                 720 


Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
                725                 730                 735     


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
            740                 745                 750         


Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
        755                 760                 765             


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
    770                 775                 780                 


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
785                 790                 795                 800 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
                805                 810                 815     


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
            820                 825                 830         


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser 
        835                 840                 845             


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
    850                 855                 860                 


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
865                 870                 875                 880 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                885                 890                 895     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            900                 905                 910         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        915                 920                 925             


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    930                 935                 940                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
945                 950                 955                 960 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                965                 970                 975     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            980                 985                 990         


Ala Leu Pro Pro Arg 
        995         


<210>  20
<211>  2994
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  20
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatgtgg tgatgaccca gagccatcgc tttatgagca ccagcgtggg cgatcgcgtg      120

agcattacct gccgcgcgag ccaggatgtg aacaccgcgg tgagctggta tcagcagaaa      180

ccgggccaga gcccgaaact gctgattttt agcgcgagct atcgctatac cggcgtgccg      240

gatcgcttta ccggcagcgg cagcggcgcg gattttaccc tgaccattag cagcgtgcag      300

gcggaagatc tggcggtgta ttattgccag cagcattata gcaccccgtg gacctttggc      360

ggcggcacca aactggaaat taaaggaggg gggggatccg ggggaggagg ctccggcgga      420

ggcggaagcc agattcagct ggtgcagagc ggcccggatc tgaaaaaacc gggcgaaacc      480

gtgaaactga gctgcaaagc gagcggctat acctttacca actttggcat gaactgggtg      540

aaacaggcgc cgggcaaagg ctttaaatgg atggcgtgga ttaacaccac ccgctatacc      600

ggcgaaagct attttgcgga tgattttaaa ggccgctttg cgtttagcgt ggaaaccagc      660

gcgaccaccg cgtatctgca gattaacaac ctgaaaaccg aagataccgc gacctatttt      720

tgcgcgcgcg gcgaaattta ttatggctat gatggcggct ttgcgtattg gggccagggc      780

accctggtga ccgtgagcgc gaccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgcggaagcg gagccaccaa cttcagcctg     1500

ctgaagcagg ccggcgacgt ggaggagaac cccggccccg ccttaccagt gaccgccttg     1560

ctcctgccgc tggccttgct gctccacgcc gccaggccgg atattcagat gacccagagc     1620

ccgagcagcc tgagcgcgag cgtgggcgat cgcgtgacca ttacctgcaa agcgagccag     1680

gatgtgggca ttgcggtggc gtggtatcag cagaaaccgg gcaaagtgcc gaaactgctg     1740

atttattggg cgagcacccg ccataccggc gtgccggatc gctttagcgg cagcggcagc     1800

ggcaccgatt ttaccctgac cattagcagc ctgcagccgg aagatgtggc gacctattat     1860

tgccagcagt atagcagcta tccgtatacc tttggccagg gcaccaaagt ggaaattaaa     1920

ggaggggggg gatccggggg aggaggctcc ggcggaggcg gaagcgaagt gcagctggtg     1980

gaaagcggcg gcggcctggt gcagccgggc ggcagcctgc gcctgagctg cgcggcgagc     2040

ggctttgatt ttagccgcta ttggatgagc tgggtgcgcc aggcgccggg caaaggcctg     2100

gaatggattg gcgaaattaa cccggatagc agcaccatta actatgcgcc gagcctgaaa     2160

gataaattta ttattagccg cgataacgcg aaaaacagcc tgtatctgca gatgaacagc     2220

ctgcgcgcgg aagataccgc ggtgtattat tgcgcgcgcc cggatggcaa ctattggtat     2280

tttgatgtgt ggggccaggg caccctggtg accgtgagca gcaccacgac gccagcgccg     2340

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     2400

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     2460

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     2520

ctttactgca ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     2580

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     2640

gcctatcgct ccagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     2700

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     2760

aagagacgtg gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag     2820

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     2880

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     2940

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           2994


<210>  21
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Ser His Arg Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala 
            180                 185                 190         


Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
225                 230                 235                 240 


Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
                485                 490                 495     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            500                 505                 510         


Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
        515                 520                 525             


Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    530                 535                 540                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
545                 550                 555                 560 


Val Gly Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
                565                 570                 575     


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
            580                 585                 590         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        595                 600                 605             


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser 
    610                 615                 620                 


Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                645                 650                 655     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            660                 665                 670         


Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr Trp Met 
        675                 680                 685             


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu 
    690                 695                 700                 


Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys Asp 
705                 710                 715                 720 


Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
                725                 730                 735     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            740                 745                 750         


Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
        755                 760                 765             


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
    770                 775                 780                 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
785                 790                 795                 800 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
                805                 810                 815     


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            820                 825                 830         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        835                 840                 845             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    850                 855                 860                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
865                 870                 875                 880 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                885                 890                 895     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            900                 905                 910         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        915                 920                 925             


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    930                 935                 940                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
945                 950                 955                 960 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                965                 970                 975     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            980                 985                 990         


Ala Leu Pro Pro Arg 
        995         


<210>  22
<211>  3009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  22
cgatcgcatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc       60

cgccaggccg gatgtggtga tgacccagag ccatcgcttt atgagcacca gcgtgggaga      120

tcgagtgagc attacctgcc gcgcgagcca ggatgtgaac accgcggtga gctggtatca      180

gcagaaaccg ggccagagcc cgaaactgct gatttttagc gcgagctatc gctataccgg      240

cgtgccggat cgctttaccg gcagcggcag cggcgcggat tttaccctga ccattagcag      300

cgtgcaggcg gaagatctgg cggtgtatta ttgccagcag cattatagca ccccgtggac      360

ctttggcggc ggcaccaaac tggatattaa aggagggggg ggatccgggg gaggaggctc      420

cggcggaggc ggaagccaga ttcagctggt gcagagcggc ccggatctga aaaaaccggg      480

cgaaaccgtg aaactgagct gcaaagcgag cggctatacc tttaccaact ttggcatgaa      540

ctgggtgaaa caggcgccgg gcaaaggctt taaatggatg gcgtggatta acacctatac      600

cggcgaaagc tattttgcgg atgattttaa aggccgcttt gcgtttagcg tggaaaccag      660

cgcgaccacc gcgtatctgc agattaacaa cctgaaaacc gaagataccg cgacctattt      720

ttgcgcgcgc ggcgaaattt attatggcta tgatggcggc tttgcgtatt ggggccaggg      780

caccctggtg accgtgagcg cgaccacgac gccagcgccg cgaccaccaa caccggcgcc      840

caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg      900

cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc      960

cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag     1020

aaagaaactc ctgtatatat tcaagcaacc atttatgaga ccagtacaaa ctactcaaga     1080

ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt     1140

gaagttcagc aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa     1200

cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga     1260

ccctgagatg gggggaaagc cgcagagaag gaagaaccct caggaaggcc tgtacaatga     1320

actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg     1380

gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta     1440

cgacgccctt cacatgcagg ccctgccccc tcgcggaagc ggagccacca acttcagcct     1500

gctgaagcag gccggcgacg tggaggagaa ccccggcccc atggccttac cagtgaccgc     1560

cttgctcctg ccgctggcct tgctgctcca cgccgccagg ccggatattc agatgaccca     1620

gagcccgagc agcctgagcg cgagcgtggg cgaccgcgtg accattacct gcaaagcgag     1680

ccaggatgtg ggcattgcgg tggcgtggta tcagcagaaa ccgggcaaag tgccgaaact     1740

gctgatttat tgggcgagca cccgccatac cggcgtgccg gatcgcttta gcggcagcgg     1800

cagcggcacc gattttaccc tgaccattag cagcctgcag ccggaagatg tggcgaccta     1860

ttattgccag cagtatagca gctatccgta tacctttggc cagggcacca aagtggaaat     1920

taaaggaggg gggggatccg ggggaggagg ctccggcgga ggcggaagcg aagtgcagct     1980

ggtggaaagc ggcggcggcc tggtgcagcc gggcggcagc ctgcgcctga gctgcgcggc     2040

gagcggcttt gattttagcc gctattggat gagctgggtg cgccaggcgc cgggcaaagg     2100

cctggaatgg attggcgaaa ttaacccgga tagcagcacc attaactatg cgccgagcct     2160

gaaagataaa tttattatta gccgcgataa cgcgaaaaac agcctgtatc tgcagatgaa     2220

cagcctgcgc gcggaagata ccgcggtgta ttattgcgcg cgcccggatg gcaactattg     2280

gtattttgat gtgtggggcc agggcaccct ggtgaccgtg agcagcacca cgacgccagc     2340

gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga     2400

ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg gggctggact tcgcctgtga     2460

tatctacatc tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat     2520

caccctttac tgcaaacggg gcagaaagaa actcctgtat atattcaagc aaccatttat     2580

gagaccagta caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga     2640

agaaggagga tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacca     2700

gcagggccag aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt     2760

tttggacaag agacgtggcc gggaccctga gatgggggga aagccgcaga gaaggaagaa     2820

ccctcaggaa ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga     2880

gattgggatg aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct     2940

cagtacagcc accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta     3000

agtttaaac                                                             3009


<210>  23
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  23
agctagctgc agtaacgcca ttttgcaagg catggaaaaa taccaaacca agaatagaga       60

agttcagatc aagggcgggt acatgaaaat agctaacgtt gggccaaaca ggatatctgc      120

ggtgagcagt ttcggccccg gcccggggcc aagaacagat ggtcaccgca gtttcggccc      180

cggcccgagg ccaagaacag atggtcccca gatatggccc aaccctcagc agtttcttaa      240

gacccatcag atgtttccag gctcccccaa ggacctgaaa tgaccctgcg ccttatttga      300

attaaccaat cagcctgctt ctcgcttctg ttcgcgcgct tctgcttccc gagctctata      360

aaagagctca caacccctca ctcggcgcgc cagtcctccg acagactgag tcgcccgggt      420

acc                                                                    423


<210>  24
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  24

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser 
                165 


<210>  25
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  25

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala 
    50                  


<210>  26
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  26

Ser Gly Pro Val Lys Glu Leu Val Gly Ser Val Gly Gly Ala Val Thr 
1               5                   10                  15      


Phe Pro Leu Lys Ser Lys Val Lys Gln Val Asp Ser Ile Val Trp Thr 
            20                  25                  30          


Phe Asn Thr Thr Pro Leu Val Thr Ile Gln Pro Glu Gly Gly Thr Ile 
        35                  40                  45              


Ile Val Thr Gln Asn Arg Asn Arg Glu Arg Val Asp Phe Pro Asp Gly 
    50                  55                  60                  


Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys Lys Asn Asp Ser Gly Ile 
65                  70                  75                  80  


Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu Gln Gln Pro Ser Thr Gln 
                85                  90                  95      


Glu Tyr Val Leu His Val Tyr Glu His Leu Ser Lys Pro Lys Val Thr 
            100                 105                 110         


Met Gly Leu Gln Ser Asn Lys Asn Gly Thr Cys Val Thr Asn Leu Thr 
        115                 120                 125             


Cys Cys Met Glu His Gly Glu Glu Asp Val Ile Tyr Thr Trp Lys Ala 
    130                 135                 140                 


Leu Gly Gln Ala Ala Asn Glu Ser His Asn Gly Ser Ile Leu Pro Ile 
145                 150                 155                 160 


Ser Trp Arg Trp Gly Glu Ser Asp Met Thr Phe Ile Cys Val Ala Arg 
                165                 170                 175     


Asn Pro Val Ser Arg Asn Phe Ser Ser Pro Ile Leu Ala Arg Lys Leu 
            180                 185                 190         


Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser Ser Met 
        195                 200                 


<210>  27
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  27

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys 
        35                  40                  45      


<210>  28
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  28

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210>  29
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  29

Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu Arg Met Lys Ala 
1               5                   10                  15      


Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn Val Thr Asp Ile 
            20                  25                  30          


Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala Val Asn Asn Ser 
        35                  40                  45              


Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val Thr Asn Tyr Thr 
    50                  55                  60                  


Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile Leu Phe Pro Glu 
65                  70                  75                  80  


Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu Thr Cys Trp Ile 
                85                  90                  95      


His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val Gly Pro Gly Ala 
            100                 105                 110         


Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val Ala Asn Arg Arg 
        115                 120                 125             


Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala Gln Gly Thr Arg 
    130                 135                 140                 


Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser Ser Gly Ser Gln 
145                 150                 155                 160 


Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala Phe Gly Ile Pro 
                165                 170                 175     


Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu Ile Leu Thr Pro 
            180                 185                 190         


Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser Phe Met His Trp 
        195                 200                 205             


Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr Glu Leu Gln Ile 
    210                 215                 220                 


Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val Arg Asp Arg Thr 
225                 230                 235                 240 


Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val Gln Ile Arg Ala 
                245                 250                 255     


Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser Thr Pro Gln Arg 
            260                 265                 270         


Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg Ala Trp Arg 
        275                 280                 285         


<210>  30
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  30

Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
1               5                   10                  15      


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
            20                  25                  30          


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
        35                  40                  45              


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
    50                  55                  60                  


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
                85                  90                  95      


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
            100                 105                 110         


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
        115                 120                 125             


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
    130                 135                 140                 


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
145                 150                 155                 160 


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
                165                 170                 175     


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
            180                 185                 190         


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
        195                 200                 205             


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
    210                 215                 220                 


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
225                 230                 235                 240 


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
                245                 250                 255     


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
            260                 265                 270         


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  31

Pro Ile Cys Val Thr Val 
1               5       


<210>  32
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  32

Lys Ile Ser His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala 
1               5                   10                  15      


His Thr Pro Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser 
            20                  25                  30          


Glu Lys Asn Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser 
        35                  40                  45          


<210>  33
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  33

Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu Tyr Ala Trp 
1               5                   10                  15      


Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala Leu Asp Gly 
            20                  25                  30          


Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr Asn Lys Asn 
        35                  40                  45              


Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr Lys Asp Gly 
    50                  55                  60                  


Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly Asp Lys Asn 
65                  70                  75                  80  


Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn Asp Ser Gly 
                85                  90                  95      


Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp Met Glu Arg 
            100                 105                 110         


Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Leu 
        115                 120                 125             


Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr Cys Leu Leu 
    130                 135                 140                 


Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp Leu Leu Glu 
145                 150                 155                 160 


Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser Leu Thr Ile 
                165                 170                 175     


Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro Gln Trp Ser 
            180                 185                 190         


His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala Asp Gly Lys 
        195                 200                 205             


Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His Thr Pro Lys 
    210                 215                 220                 


Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg Glu Gly Asp 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro Glu Tyr Thr 
                245                 250                 255     


Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys Gln Asn Thr 
            260                 265                 270         


Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser Gly Lys Tyr 
        275                 280                 285             


Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser Glu Glu Val 
    290                 295                 300                 


Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val Gln Ile Leu 
305                 310                 315                 320 


His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu Cys Met Ser 
                325                 330                 335     


Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His Asn Gly Lys 
            340                 345                 350         


Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro Lys Ile Leu 
        355                 360                 365             


Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn Ile Leu Gly 
    370                 375                 380                 


Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln Tyr Pro Pro 
385                 390                 395                 400 


Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile Arg Glu Gly 
                405                 410                 415     


Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn Pro Ser Val 
            420                 425                 430         


Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu Pro Ser Leu 
        435                 440                 445             


Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr Thr Ile Ala 
    450                 455                 460                 


Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro Val Ala Leu 
465                 470                 475                 480 


<210>  34
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  34

Gln Ser Pro Thr Pro Ser Pro Thr Gly Leu Thr Thr Ala Lys Met Pro 
1               5                   10                  15      


Ser Val Pro Leu Ser Ser Asp Pro Leu Pro Thr His Thr Thr Ala Phe 
            20                  25                  30          


Ser Pro Ala Ser Thr Phe Glu Arg Glu Asn Asp Phe Ser Glu Thr Thr 
        35                  40                  45              


Thr Ser Leu Ser Pro Asp Asn Thr Ser Thr Gln Val Ser Pro Asp Ser 
    50                  55                  60                  


Leu Asp Asn Ala Ser Ala Phe Asn Thr Thr Gly Val Ser Ser Val Gln 
65                  70                  75                  80  


Thr Pro His Leu Pro Thr His Ala Asp Ser Gln Thr Pro Ser Ala Gly 
                85                  90                  95      


Thr Asp Thr Gln Thr Phe Ser Gly Ser Ala Ala Asn Ala Lys Leu Asn 
            100                 105                 110         


Pro Thr Pro Gly Ser Asn Ala Ile Ser Asp Val Pro Gly Glu Arg Ser 
        115                 120                 125             


Thr Ala Ser Thr Phe Pro Thr Asp Pro Val Ser Pro Leu Thr Thr Thr 
    130                 135                 140                 


Leu Ser Leu Ala His His Ser Ser Ala Ala Leu Pro Ala Arg Thr Ser 
145                 150                 155                 160 


Asn Thr Thr Ile Thr Ala Asn Thr Ser Asp Ala Tyr Leu Asn Ala Ser 
                165                 170                 175     


Glu Thr Thr Thr Leu Ser Pro Ser Gly Ser Ala Val Ile Ser Thr Thr 
            180                 185                 190         


Thr Ile Ala Thr Thr Pro Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala 
        195                 200                 205             


Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr 
    210                 215                 220                 


Ala Lys Leu Asn Val Asn Glu Asn Val Glu Cys Gly Asn Asn Thr Cys 
225                 230                 235                 240 


Thr Asn Asn Glu Val His Asn Leu Thr Glu Cys Lys Asn Ala Ser Val 
                245                 250                 255     


Ser Ile Ser His Asn Ser Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu 
            260                 265                 270         


Asp Val Pro Pro Gly Val Glu Lys Phe Gln Leu His Asp Cys Thr Gln 
        275                 280                 285             


Val Glu Lys Ala Asp Thr Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu 
    290                 295                 300                 


Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly 
305                 310                 315                 320 


Asn Met Ile Phe Asp Asn Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro 
                325                 330                 335     


Glu His Glu Tyr Lys Cys Asp Ser Glu Ile Leu Tyr Asn Asn His Lys 
            340                 345                 350         


Phe Thr Asn Ala Ser Lys Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly 
        355                 360                 365             


Glu Pro Gln Ile Ile Phe Cys Arg Ser Glu Ala Ala His Gln Gly Val 
    370                 375                 380                 


Ile Thr Trp Asn Pro Pro Gln Arg Ser Phe His Asn Phe Thr Leu Cys 
385                 390                 395                 400 


Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu 
                405                 410                 415     


Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu 
            420                 425                 430         


Ser Leu His Ala Tyr Ile Ile Ala Lys Val Gln Arg Asn Gly Ser Ala 
        435                 440                 445             


Ala Met Cys His Phe Thr Thr Lys Ser Ala Pro Pro Ser Gln Val Trp 
    450                 455                 460                 


Asn Met Thr Val Ser Met Thr Ser Asp Asn Ser Met His Val Lys Cys 
465                 470                 475                 480 


<210>  35
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  35

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg 
65  


<210>  36
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  36

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala 
            20                  25                  30          


Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
        35                  40                  45              


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
    50                  55                  60                  


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
65                  70                  75                  80  


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
                85                  90                  95      


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
            100                 105                 110         


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
        115                 120                 125             


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
    130                 135                 140                 


Ile Val Gln Met Phe Ile Asn Thr Ser 
145                 150             


