                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche, AG
       Hoffmann-La Roche, Inc.
       The United States of America, as Represented by the 
       Secretary, Department of Health and Human Services
 
<120>  BIOMARKERS FOR NAD(+)-DIPHTHAMIDE ADP RIBOSYLTRANSFERASE 
       SENSITIVITY AND RESISTANCE

<130>  CMD/FP7201569

<150>  US 62/183900
<151>  2015-06-24

<160>  112   

<170>  PatentIn version 3.3

<210>  1
<211>  613
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  1

Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
385                 390                 395                 400 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
                405                 410                 415     


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
    450                 455                 460                 


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
465                 470                 475                 480 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
                485                 490                 495     


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
            500                 505                 510         


Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
        515                 520                 525             


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
    530                 535                 540                 


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
545                 550                 555                 560 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
                565                 570                 575     


Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln 
            580                 585                 590         


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro 
        595                 600                 605             


Arg Glu Asp Leu Lys 
    610             


<210>  2
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence of PE38

<400>  2

Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    50                  55                  60                  


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
65                  70                  75                  80  


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                85                  90                  95      


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
            100                 105                 110         


Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr 
        115                 120                 125             


Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg 
    130                 135                 140                 


Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln 
145                 150                 155                 160 


Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu 
                165                 170                 175     


Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln 
            180                 185                 190         


Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala 
        195                 200                 205             


Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg 
    210                 215                 220                 


Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu 
225                 230                 235                 240 


Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala 
                245                 250                 255     


Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp 
            260                 265                 270         


Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu 
        275                 280                 285             


Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro 
    290                 295                 300                 


Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro 
305                 310                 315                 320 


Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro 
                325                 330                 335     


Gly Lys Pro Pro Arg Glu Asp Leu Lys 
            340                 345 


<210>  3
<211>  535
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  3

Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu Asn 
1               5                   10                  15      


Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile Gln 
            20                  25                  30          


Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp Asp 
        35                  40                  45              


Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala Gly 
    50                  55                  60                  


Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly Val 
65                  70                  75                  80  


Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys Val 
                85                  90                  95      


Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr Glu 
            100                 105                 110         


Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe Gly 
        115                 120                 125             


Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu Ser 
145                 150                 155                 160 


Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln Asp 
                165                 170                 175     


Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val Arg 
            180                 185                 190         


Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp Val 
        195                 200                 205             


Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
    210                 215                 220                 


Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser Glu 
225                 230                 235                 240 


Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu Glu 
                245                 250                 255     


His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro Val 
            260                 265                 270         


Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln Val 
        275                 280                 285             


Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala Leu 
    290                 295                 300                 


Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly Ala 
305                 310                 315                 320 


Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu Ser 
                325                 330                 335     


Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val Asp 
            340                 345                 350         


Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu Phe 
        355                 360                 365             


Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly His 
    370                 375                 380                 


Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser Trp Asn Thr 
385                 390                 395                 400 


Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu Ser Gly His 
                405                 410                 415     


Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile Ala Gly Val 
            420                 425                 430         


Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys Ser Lys Thr 
        435                 440                 445             


His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile 
    450                 455                 460                 


Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val Tyr Val Gly 
465                 470                 475                 480 


Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg Ser Ser Ser 
                485                 490                 495     


Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile Gly Val Leu 
            500                 505                 510         


Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser Lys Leu Ser 
        515                 520                 525             


Leu Phe Phe Glu Ile Lys Ser 
    530                 535 


<210>  4
<211>  634
<212>  PRT
<213>  Vibrio cholera

<400>  4

Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210>  5
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  5
caggtgatgg cggcgctggt cgtatccggg gcagcgga                             38


<210>  6
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  6
cagcggagca ggcga                                                      15


<210>  7
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  7
caggtgatgg cggcgctggt cgtatcgtat ccggggcagc gga                       43


<210>  8
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  8
caggtgatgg cggcggtccg gggcagcgga                                      30


<210>  9
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  9
cagccatcac ctggcccggg gcagcgga                                        28


<210>  10
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  10
caggtgatgg cggcgctggt cgtatcgtat ccggggcagc gga                       43


<210>  11
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  11
ccctgcagct gctgcgtgga tgtgctgggt gctgagcaag ct                        42


<210>  12
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  12
ccctgcagct gctgcgtgga tggatgtgct gggtgctgag caagct                    46


<210>  13
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  13
ccctgcagct ggatgtgctg ggtgctgagc aagct                                35


<210>  14
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  14
ccctgcagct gctgcgtggg tgctgggtgc tgagcaagct                           40


<210>  15
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  15
ccctgcagct gctgcgtgct gagcaagct                                       29


<210>  16
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  16
tgtaccagca ggaacagtgg aggaatgtgt acagaagtt                            39


<210>  17
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  17
tgtaccagca ggaatgtgta cagaagtt                                        28


<210>  18
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  18
tgtaccagca ggaacagtgt ggggaggaat gtgtacagaa gtt                       43


<210>  19
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  19
ctatgaacct ccacggtata tgagtgtaaa ccaagcagcc cag                       43


<210>  20
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  20
ctatgaacct ccacggtata tgagtgagtg taaaccaagc agcccag                   47


<210>  21
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  21
ctatgaacct ccacggtata tgagagtgta aaccaagcag cccag                     45


<210>  22
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  22
ctatgaacct ccacggtata tgtaaaccaa gcagcccag                            39


<210>  23
<211>  44
<212>  DNA
<213>  Homo sapiens

<400>  23
ggtaacttca gggtcccgcc cggcggttca cccaagcaag cgca                      44


<210>  24
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  24
ggtaacttca gggtccggcg gttcacccaa gcaagcgca                            39


<210>  25
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  25
agcaatggct cttcccctct atcgccgaac cataagagga ag                        42


<210>  26
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  26
agcaatggct cttcccctct atgcgccgaa ccataagagg aag                       43


<210>  27
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  27
agcaatggct cttcccctct ctatcgccga accataagag gaag                      44


<210>  28
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  28
cctctcctca ggtgtcacat cccggtggct ggacatgcc                            39


<210>  29
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  29
cctctcctca ggtgtcacat acatcccggt ggctggacat gcc                       43


<210>  30
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Allele sequence of mutated MCF-7 clone

<400>  30
cctctcctca ggtgtctgga catgcc                                          26


<210>  31
<211>  11
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  31

Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
1               5                   10      


<210>  32
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic linker

<400>  32

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  33
<211>  5
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  33

Arg Glu Asp Leu Lys 
1               5   


<210>  34
<211>  4
<212>  PRT
<213>  Vibrio cholerae

<400>  34

Lys Asp Glu Leu 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  35

Arg Glu Asp Leu 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Endoplasmic reticulum localisation sequence

<400>  36

Arg Asp Glu Leu 
1               


<210>  37
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Endoplasmic reticulum localisation sequence

<400>  37

Lys Glu Asp Leu Lys 
1               5   


<210>  38
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: 2 tandem repeats of KDEL

<400>  38

Lys Asp Glu Leu Lys Asp Glu Leu 
1               5               


<210>  39
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: 3 tandem repeats of KDEL

<400>  39

Lys Asp Glu Leu Lys Asp Glu Leu Lys Asp Glu Leu 
1               5                   10          


<210>  40
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic: Minimal furin-cleavable sequence

<220>
<221>  VARIANT
<222>  (2)..(3)
<223>  Xaa is any naturally occurring amino acid

<400>  40

Arg Xaa Xaa Arg 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Furin cleavage motif

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is any naturally occurring amino acid

<400>  41

Arg Xaa Arg Arg 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Furin cleavage motif

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is any naturally occurring amino acid

<400>  42

Arg Xaa Lys Arg 
1               


<210>  43
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  43

Arg His Arg Ser Lys Arg Gly Trp Glu Gln Leu 
1               5                   10      


<210>  44
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  44

Arg Lys Lys Arg 
1               


<210>  45
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  45

Arg Arg Arg Arg 
1               


<210>  46
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  46

Arg Lys Ala Arg 
1               


<210>  47
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  47

Ser Arg Val Ala Arg Ser 
1               5       


<210>  48
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  48

Thr Ser Ser Arg Lys Arg Arg Phe Trp 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  49

Ala Ser Arg Arg Lys Ala Arg Ser Trp 
1               5                   


<210>  50
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  50

Arg Arg Val Lys Lys Arg Phe Trp 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  51

Arg Asn Val Val Arg Arg Asp Trp 
1               5               


<210>  52
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  52

Thr Arg Ala Val Arg Arg Arg Ser Trp 
1               5                   


<210>  53
<211>  4
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  53

Arg Gln Pro Arg 
1               


<210>  54
<211>  8
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  54

Arg His Arg Gln Pro Arg Gly Trp 
1               5               


<210>  55
<211>  9
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  55

Arg His Arg Gln Pro Arg Gly Trp Glu 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  56

His Arg Gln Pro Arg Gly Trp Glu Gln 
1               5                   


<210>  57
<211>  7
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  57

Arg Gln Pro Arg Gly Trp Glu 
1               5           


<210>  58
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  58

Arg Ser Lys Arg 
1               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  59

Arg His Arg Ser Lys Arg Gly Trp 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  60

His Arg Ser Lys Arg Gly Trp Glu 
1               5               


<210>  61
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  61

Arg Ser Lys Arg Gly Trp Glu Gln Leu 
1               5                   


<210>  62
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  62

His Arg Ser Lys Arg Gly Trp Glu Gln Leu 
1               5                   10  


<210>  63
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic furin-cleavable sequence

<400>  63

Arg His Arg Ser Lys Arg 
1               5       


<210>  64
<211>  4
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  64

Arg Val Arg Arg 
1               


<210>  65
<211>  11
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  65

Gly Asn Arg Val Arg Arg Ser Val Gly Ser Ser 
1               5                   10      


<210>  66
<211>  4
<212>  PRT
<213>  Vibrio cholerae

<400>  66

Arg Lys Pro Arg 
1               


<210>  67
<211>  6
<212>  PRT
<213>  Vibrio cholerae

<400>  67

Arg Lys Asp Glu Leu Lys 
1               5       


<210>  68
<211>  11
<212>  PRT
<213>  Vibrio cholerae

<400>  68

Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp 
1               5                   10      


<210>  69
<211>  11
<212>  PRT
<213>  Vibrio cholerae

<400>  69

Arg Gly Arg Lys Pro Arg Asp Leu Thr Asp Asp 
1               5                   10      


<210>  70
<211>  11
<212>  PRT
<213>  Vibrio cholerae

<400>  70

Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp 
1               5                   10      


<210>  71
<211>  5
<212>  PRT
<213>  Vibrio cholerae

<400>  71

His Asp Glu Leu Lys 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  72

Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln Ile Ile Pro 
1               5                   10                  15      


Thr 
    


<210>  73

<400>  73
000

<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys 
1               5                   10                  15      


Ala Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys 
            20                  25                  30          


Ser Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser 
        35                  40                  45              


Ala Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln 
    50                  55                  60                  


Glu Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu 
65                  70                  75                  80  


Leu Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala 
                85                  90                  95      


Gly Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser 
            100                 105                 110         


Ser Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val 
        115                 120                 125             


Val Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg 
    130                 135                 140                 


Gln Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met 
145                 150                 155                 160 


Asp Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln 
                165                 170                 175     


Thr Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr 
            180                 185                 190         


Gly Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val 
        195                 200                 205             


Leu Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr 
    210                 215                 220                 


Leu Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly 
225                 230                 235                 240 


Glu Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met 
                245                 250                 255     


Met Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys 
            260                 265                 270         


Phe Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr 
        275                 280                 285             


Phe Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile 
    290                 295                 300                 


Met Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp 
305                 310                 315                 320 


Ile Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu 
                325                 330                 335     


Lys Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln 
            340                 345                 350         


Met Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg 
        355                 360                 365             


Cys Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly 
    370                 375                 380                 


Ile Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys 
385                 390                 395                 400 


Met Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val 
                405                 410                 415     


Phe Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro 
            420                 425                 430         


Asn Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln 
        435                 440                 445             


Arg Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val 
    450                 455                 460                 


Pro Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val 
465                 470                 475                 480 


Lys Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val 
                485                 490                 495     


Met Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys 
            500                 505                 510         


Asn Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala 
        515                 520                 525             


Lys Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His 
    530                 535                 540                 


Ile Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp 
545                 550                 555                 560 


Leu Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val 
                565                 570                 575     


Val Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu 
            580                 585                 590         


Ser Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro 
        595                 600                 605             


Phe Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala 
    610                 615                 620                 


Arg Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu 
625                 630                 635                 640 


Trp Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly 
                645                 650                 655     


Thr Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu 
            660                 665                 670         


Asn Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys 
        675                 680                 685             


Glu Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val 
    690                 695                 700                 


His Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln 
705                 710                 715                 720 


Ile Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala 
                725                 730                 735     


Gln Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro 
            740                 745                 750         


Glu Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly 
        755                 760                 765             


His Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val 
    770                 775                 780                 


Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu 
785                 790                 795                 800 


Arg Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His 
                805                 810                 815     


Trp Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser 
            820                 825                 830         


Gln Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile 
        835                 840                 845             


Pro Ala Leu Asp Asn Phe Leu Asp Lys Leu 
    850                 855             


<210>  102
<211>  114
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  102

Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro Leu 
1               5                   10                  15      


Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser Ser Ile Ala Leu 
            20                  25                  30          


Asn Trp Val Arg Gln Ala Ala Gly Lys Gly Leu Asp Trp Ile Gly Val 
        35                  40                  45              


Thr Ser Asp Thr Gly Ala Thr Tyr Tyr Ser Ser Trp Ala Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Ile Pro Ser 
65                  70                  75                  80  


Pro Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ile Val Val 
                85                  90                  95      


Val Gly Ser Asn Met Asn Leu Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  103
<211>  112
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  103

Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Met Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn Asn 
            20                  25                  30          


Arg Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Glu 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Ser Cys Leu Gly Ala Tyr Asp Cys Ile 
                85                  90                  95      


Thr Ala Asp Cys Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


<210>  104
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  104

Gly Ile Asp Leu Ser Ser Ile Ala Leu Asn 
1               5                   10  


<210>  105
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  105

Val Thr Ser Asp Thr Gly Ala Thr Tyr Tyr Ser Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  106
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  106

Ile Val Val Val Gly Ser Asn Met Asn Leu 
1               5                   10  


<210>  107
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  107

Gln Ala Ser Gln Ser Val Tyr Asn Asn Asn Arg Leu Ala 
1               5                   10              


<210>  108
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  108

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  109
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  109

Leu Gly Ala Tyr Asp Cys Ile Thr Ala Asp Cys Phe Ala 
1               5                   10              


<210>  110
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  110

Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser 
1               5                   10                  15      


Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His 
            20                  25                  30          


Ala Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        35                  40                  45              


Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Ala Ala Arg 
    50                  55                  60                  


Ser Gln Asp Leu Ala Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp 
65                  70                  75                  80  


Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala 
                85                  90                  95      


Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Ala Ser 
            100                 105                 110         


Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu 
        115                 120                 125             


Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Ala 
    130                 135                 140                 


Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr 
145                 150                 155                 160 


Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala 
                165                 170                 175     


Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser 
            180                 185                 190         


Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser 
        195                 200                 205             


Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
    210                 215                 


<210>  111
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  111

Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser 
1               5                   10                  15      


Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His 
            20                  25                  30          


Ala Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        35                  40                  45              


Ala Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg 
    50                  55                  60                  


Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp 
65                  70                  75                  80  


Pro Ala His Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg 
                85                  90                  95      


Gly Arg Ile Ala Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Ala Ser 
            100                 105                 110         


Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu 
        115                 120                 125             


Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg 
    130                 135                 140                 


Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Glu Glu Thr 
145                 150                 155                 160 


Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala 
                165                 170                 175     


Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser 
            180                 185                 190         


Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser 
        195                 200                 205             


Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
    210                 215                 


<210>  112
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  112

Asp Lys Thr His Lys Ala Ser Gly Gly Arg His Arg Gln Pro Arg Gly 
1               5                   10                  15      


Trp Glu Gln Leu Gly Gly Gly Gly Gly Ser 
            20                  25      


