                         SEQUENCE LISTING

<110>  Inserm
 
<120>  METHODS AND KITS FOR DETECTING PROTEIN-PROTEIN INTERACTIONS

<130>  BIO15012 CABANTOUS

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP1-9 OPT WT

<400>  1

Met Arg Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Ile 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Phe Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Ser Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Thr Ile Arg His Asn Val Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro 
        195     


<210>  2
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP1-9 OPT1

<400>  2

Met Arg Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Ile 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Phe Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Ile Gly Lys Leu Ser Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Tyr Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Gln Asn Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Thr Ile Arg His Asn Val Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro 
        195     


<210>  3
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP1-9 OPT2

<400>  3

Met Arg Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Ile 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Phe Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Ile Gly Lys Leu Ser Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Tyr Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Pro His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Thr Ile Arg His Asn Val Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Glu His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro 
        195     


<210>  4
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP1-9 OPT3

<400>  4

Met Val Arg Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Ile Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Phe Val Arg Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Ile Gly Lys Leu Ser Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Tyr Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Phe Asn Ser His Lys Val Tyr Ile Thr Ala Asp Lys Gln Asn Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Thr Ile Arg His Asn Val Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Asp 
        195 


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10

<400>  5

Met Gly Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser 
1               5                   10                  15      


Lys Asp Pro Asn 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10

<400>  6

Met Asp Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Thr Ile Leu Leu 
1               5                   10                  15      


Lys Asp Leu Asn 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10

<400>  7

Met Asp Leu Pro Asp Asp His Tyr Leu Ser Thr Gln Thr Ile Leu Ser 
1               5                   10                  15      


Lys Asp Leu Asn 
            20  


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP11

<400>  8

Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
1               5                   10                  15      


Ile Thr Gly Ala Ser 
            20      


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP11

<400>  9

Glu Lys Arg Asp His Met Val Leu Leu Glu Tyr Val Thr Ala Ala Gly 
1               5                   10                  15      


Ile Thr Asp Ala Ser 
            20      


<210>  10
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10-RhoA


<220>
<221>  misc_feature
<222>  (127)..(127)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Met Gly Asp Leu Pro Asp Asp His Tyr Leu Ser Thr Gln Thr Ile Leu 
1               5                   10                  15      


Ser Lys Asp Leu Asn Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Ser Gly Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly 
        35                  40                  45              


Ala Cys Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe 
    50                  55                  60                  


Pro Glu Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile 
65                  70                  75                  80  


Glu Val Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly 
                85                  90                  95      


Gln Glu Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp 
            100                 105                 110         


Val Ile Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Xaa Asn 
        115                 120                 125             


Ile Pro Xaa Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val 
    130                 135                 140                 


Pro Ile Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His 
145                 150                 155                 160 


Thr Arg Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu 
                165                 170                 175     


Glu Gly Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu 
            180                 185                 190         


Cys Ser Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala 
        195                 200                 205             


Thr Arg Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys 
    210                 215                 220                 


Leu Val Leu 
225         


<210>  11
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10-RhoB

<400>  11

Met Gly Asp Leu Pro Asp Asp His Tyr Leu Ser Thr Gln Thr Ile Leu 
1               5                   10                  15      


Ser Lys Asp Leu Asn Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Ser Gly Ala Ala Ile Arg Lys Lys Leu Val Val Val Gly Asp Gly 
        35                  40                  45              


Ala Cys Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Glu Phe 
    50                  55                  60                  


Pro Glu Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile 
65                  70                  75                  80  


Glu Val Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly 
                85                  90                  95      


Gln Glu Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp 
            100                 105                 110         


Val Ile Leu Met Cys Phe Ser Val Asp Ser Pro Asp Ser Leu Glu Asn 
        115                 120                 125             


Ile Pro Glu Lys Trp Val Pro Glu Val Lys His Phe Cys Pro Asn Val 
    130                 135                 140                 


Pro Ile Ile Leu Val Ala Asn Lys Lys Asp Leu Arg Ser Asp Glu His 
145                 150                 155                 160 


Val Arg Thr Glu Leu Ala Arg Met Lys Gln Glu Pro Val Arg Thr Asp 
                165                 170                 175     


Asp Gly Arg Ala Met Ala Val Arg Ile Gln Ala Tyr Asp Tyr Leu Glu 
            180                 185                 190         


Cys Ser Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Thr Ala 
        195                 200                 205             


Thr Arg Ala Ala Leu Gln Lys Arg Tyr Gly Ser Gln Asn Gly Cys Ile 
    210                 215                 220                 


Asn Cys Cys Lys Val Leu 
225                 230 


<210>  12
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10-HRas

<400>  12

Met Gly Asp Leu Pro Asp Asp His Tyr Leu Ser Thr Gln Thr Ile Leu 
1               5                   10                  15      


Ser Lys Asp Leu Asn Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Ser Gly Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val 
        35                  40                  45              


Gly Lys Asn Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp 
    50                  55                  60                  


Glu Tyr Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile 
65                  70                  75                  80  


Asp Gly Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu 
                85                  90                  95      


Glu Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe 
            100                 105                 110         


Leu Cys Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His 
        115                 120                 125             


Gln Tyr Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro 
    130                 135                 140                 


Met Val Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu 
145                 150                 155                 160 


Ser Arg Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile 
                165                 170                 175     


Glu Thr Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr 
            180                 185                 190         


Leu Val Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro 
        195                 200                 205             


Asp Glu Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
    210                 215                 220             


<210>  13
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10-NRas

<400>  13

Met Gly Asp Leu Pro Asp Asp His Tyr Leu Ser Thr Gln Thr Ile Leu 
1               5                   10                  15      


Ser Lys Asp Leu Asn Ile Asp Gly Ala Gly Gly Ser Pro Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Thr Glu Tyr Lys 
        35                  40                  45              


Leu Val Val Val Gly Ala Gly Gly Val Gly Lys Ser Ala Leu Thr Ile 
    50                  55                  60                  


Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr Asp Pro Thr Ile Glu 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys Leu Leu 
                85                  90                  95      


Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr Ser Ala Met Arg Asp 
            100                 105                 110         


Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys Val Phe Ala Ile Asn 
        115                 120                 125             


Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr Arg Glu Gln Ile Lys 
    130                 135                 140                 


Arg Val Lys Asp Ser Asp Asp Val Pro Met Val Leu Val Gly Asn Lys 
145                 150                 155                 160 


Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys Gln Ala His Glu Leu 
                165                 170                 175     


Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr Ser Ala Lys Thr Arg 
            180                 185                 190         


Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val Arg Glu Ile Arg Gln 
        195                 200                 205             


Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Gly Cys 
    210                 215                 220                 


Met Gly Leu Pro Cys Val Val Met 
225                 230         


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rho-binding domain of Rhotekin (RBD)-GFP11

<400>  14

Met Ile Leu Glu Asp Leu Asn Met Leu Tyr Ile Arg Gln Met Ala Leu 
1               5                   10                  15      


Ser Leu Glu Asp Thr Glu Leu Gln Arg Lys Leu Asp His Glu Ile Arg 
            20                  25                  30          


Met Arg Asp Gly Ala Cys Lys Leu Leu Ala Ala Cys Ser Gln Arg Glu 
        35                  40                  45              


Gln Ala Leu Glu Ala Thr Lys Ser Leu Leu Val Cys Asn Ser Arg Ile 
    50                  55                  60                  


Leu Ser Tyr Met Gly Glu Leu Gln Arg Arg Lys Glu Ala Gln Val Leu 
65                  70                  75                  80  


Glu Lys Thr Gly Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Ser Gly Glu Lys Arg Asp His Met Val Leu Leu Glu Tyr Val Thr Ala 
            100                 105                 110         


Ala Gly Ile Thr Asp Ala Ser 
        115                 


<210>  15
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ras binding domain of c-Raf (RsBD)-GFP11

<400>  15

Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 
1               5                   10                  15      


Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 
            20                  25                  30          


Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 
        35                  40                  45              


Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn 
    50                  55                  60                  


Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 
65                  70                  75                  80  


Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys 
                85                  90                  95      


Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu 
            100                 105                 110         


Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val 
        115                 120                 125             


Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 
    130                 135                 140                 


Thr Phe Leu Lys Leu Gly Ile His Arg Asp Ile Asp Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Ser Gly Glu Lys Arg Asp His Met Val Leu 
                165                 170                 175     


Leu Glu Tyr Val Thr Ala Ala Gly Ile Thr Asp Ala Ser 
            180                 185                 


<210>  16
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  16

Met Asp Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn 
            20                  25                  30          


Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser Tyr Glu Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala His His His His His His Gly Ala 
        115                 120                 125             


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Gly Ser Pro 
    130                 135                 140                 


Gly 
145 


<210>  17
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10-Rac1

<400>  17

Met Gly Asp Leu Pro Asp Asp His Tyr Leu Ser Thr Gln Thr Ile Leu 
1               5                   10                  15      


Ser Lys Asp Leu Asn Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Ser Gly Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly 
        35                  40                  45              


Lys Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu 
    50                  55                  60                  


Tyr Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp 
65                  70                  75                  80  


Gly Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp 
                85                  90                  95      


Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu 
            100                 105                 110         


Ile Cys Phe Ser Leu Val Ser Pro Ala Ser Phe Glu Asn Val Arg Ala 
        115                 120                 125             


Lys Trp Tyr Pro Glu Val Arg His His Cys Pro Asn Thr Pro Ile Ile 
    130                 135                 140                 


Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu 
145                 150                 155                 160 


Lys Leu Lys Glu Lys Lys Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu 
                165                 170                 175     


Ala Met Ala Lys Glu Ile Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala 
            180                 185                 190         


Leu Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala 
        195                 200                 205             


Val Leu Cys Pro Pro Pro Val Lys Lys Arg Lys Arg Lys Cys Leu Leu 
    210                 215                 220                 


Leu 
225 


<210>  18
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP10-Cdc42

<400>  18

Met Gly Asp Leu Pro Asp Asp His Tyr Leu Ser Thr Gln Thr Ile Leu 
1               5                   10                  15      


Ser Lys Asp Leu Asn Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Ser Gly Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val 
        35                  40                  45              


Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser 
    50                  55                  60                  


Glu Tyr Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile 
65                  70                  75                  80  


Gly Gly Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu 
                85                  90                  95      


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe 
            100                 105                 110         


Leu Val Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys 
        115                 120                 125             


Glu Lys Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe 
    130                 135                 140                 


Leu Leu Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile 
145                 150                 155                 160 


Glu Lys Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala 
                165                 170                 175     


Glu Lys Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser 
            180                 185                 190         


Ala Leu Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu 
        195                 200                 205             


Ala Ala Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu 
    210                 215                 220                 


Leu 
225 


<210>  19
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rac/Cdc42 (p21) binding domain (PBD) of the human p21 activated 
       kinase 1 protein (PAK)-GFP11

<400>  19

Met Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp Phe Glu His Thr 
1               5                   10                  15      


Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr Gly Met Pro 
            20                  25                  30          


Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr Lys Ser Glu 
        35                  40                  45              


Gln Ile Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Glu 
    50                  55                  60                  


Lys Arg Asp His Met Val Leu Leu Glu Tyr Val Thr Ala Ala Gly Ile 
65                  70                  75                  80  


Thr Asp Ala Ser 
                


