                         SEQUENCE LISTING

<110>  Serturner Corp.
 
<120>  METHODS AND COMPOSITIONS FOR MAKING EPHEDRINE AND RELATED 
       ALKALOID COMPOUNDS

<130>  21806-P48792PC00

<150>  US 62/183,372
<151>  2015-06-23

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1490
<212>  DNA
<213>  Ephedra sinica

<400>  1
gctgaagctg tgaaccttac ttatggtgaa tattttgtca tttgtagtgt aatagctcgc       60

cgagtcgtta tccacaccaa gaaaatccaa atatacagta catgagtagc gactggatat      120

gttaggtgcc cacgaacact cctacaacat aatccacacg tagaatccca ttatgtagca      180

tcgactcatt catctaacgg agtctcaggt acacaaagaa ataaagaacg aaagaatctg      240

aatggaagag gcgaagatgg caacgctggg cggtgcctcg tatgccatga tagtgaagac      300

aatgatgcgc tctctcgaag ccaacctaat tccggacttc gtactgagaa ggctcactcg      360

cattctcttg gcgagtcgtc tgaagctcgg atacaagcaa accgcggagc ttcagcttgc      420

tgatctcatg tcctttgttg catcgttaaa gaccatgcct atagctctct gcaccgaaga      480

agctaaaggc cagcattacg agctgcccac ttcgttcttc aagttggttc tcggcaagca      540

tctcaaatac agctcggctt acttcagtga acacacaaga actctagatg aagcagagga      600

agcaatgtta gcactgtatt gtgagagggc taagattgaa gatggccaaa agattctgga      660

tataggatgt ggatggggtt cattttcttt atatgttgct gaaagatacc caaaatgtga      720

aataactggt ctttgcaatt cctctaccca gaaggcgttt atagagcaac agtgcagtga      780

aagaagactt tgcaatgtta ctatatatgc tgatgatatt agcacttttg atacggagag      840

tacttatgat cgcataatat ctattgaaat gtttgagcac atgaaaaatt acagtactct      900

tcttaaaaaa atatcaaagt ggatgaatca ggaatgcttg ctgtttgtgc attatttttg      960

tcataagaca tttgcttacc attttgagga tgtagatgaa gatgattgga tggcaagata     1020

ctttttcaca ggtggcacaa tgcctgcaag tagcttacta ctgtattttc aggatgatgt     1080

ttcagttgtt gatcactggc ttataaatgg gaagcactat gctcaaacaa gtgaagagtg     1140

gctgaaaagg atggaccata atctatcctc tatacttcct atatttaatg aaacatatgg     1200

cgaaaatgca gctaaaaagt ggttggcata ctggcgaaca ttctttattg ccgtggctga     1260

gctttttaag tacaatgatg gagaagaatg gatggtttca cattttctgt ttaagaaaaa     1320

atagccacag catacctttt cgtatggtag aaagggtcgt tgattattgt aatttcttct     1380

attcttttcc atttgtgacc aatgctagtt aaatagtcaa acaaatttct ctagcataga     1440

ttttgaaggt taatatttca gaattccaca aaatttctct atgaggattt                1490


<210>  2
<211>  1083
<212>  DNA
<213>  Ephedra sinica

<400>  2
atggaagaag caaaaatggc gaccctgggc ggtgcgtcct atgcgatgat tgtgaaaacg       60

atgatgcgct ctctggaagc aaacctgatt ccggattttg tgctgcgtcg cctgacgcgt      120

atcctgctgg ctagtcgcct gaaactgggt tataagcaga ccgctgaact gcaactggcg      180

gatctgatgt cattcgttgc gtcgctgaaa acgatgccga ttgccctgtg caccgaagaa      240

gcaaagggtc agcattacga actgccgacc agctttttca aactggtcct gggcaaacat      300

ctgaagtata gctctgccta cttttctgaa cacacccgta cgctggatga agcggaagaa      360

gccatgctgg cactgtattg cgaacgcgcc aaaattgaag atggtcagaa gattctggac      420

atcggctgtg gttggggcag tttttccctg tatgtggcag aacgttaccc gaaatgcgaa      480

attacgggcc tgtgtaacag ttccacccaa aaagccttca tcgaacagca atgcagcgaa      540

cgtcgcctgt gtaatgttac catttatgca gatgacatca gcacctttga tacggaatct      600

acctacgacc gcattatcag catcgaaatg ttcgaacaca tgaagaacta cagtacgctg      660

ctgaagaaaa ttagcaagtg gatgaatcag gaatgcctgc tgtttgtcca ttatttctgt      720

cacaaaacct ttgcgtacca cttcgaagat gtggacgaag atgactggat ggctcgttat      780

ttctttaccg gcggcaccat gccggcgtca tcgctgctgc tgtactttca ggatgacgtc      840

tcagtggttg atcattggct gattaacggt aaacactatg ctcaaacctc ggaagaatgg      900

ctgaagcgta tggaccacaa tctgagctct attctgccga tctttaacga aacgtatggc      960

gaaaatgcgg ccaaaaagtg gctggcatac tggcgcacct ttttcatcgc agttgctgaa     1020

ctgttcaaat acaacgatgg cgaagaatgg atggtgtccc acttcctgtt caaaaagaaa     1080

taa                                                                   1083


<210>  3
<211>  360
<212>  PRT
<213>  Ephedra sinica

<400>  3

Met Glu Glu Ala Lys Met Ala Thr Leu Gly Gly Ala Ser Tyr Ala Met 
1               5                   10                  15      


Ile Val Lys Thr Met Met Arg Ser Leu Glu Ala Asn Leu Ile Pro Asp 
            20                  25                  30          


Phe Val Leu Arg Arg Leu Thr Arg Ile Leu Leu Ala Ser Arg Leu Lys 
        35                  40                  45              


Leu Gly Tyr Lys Gln Thr Ala Glu Leu Gln Leu Ala Asp Leu Met Ser 
    50                  55                  60                  


Phe Val Ala Ser Leu Lys Thr Met Pro Ile Ala Leu Cys Thr Glu Glu 
65                  70                  75                  80  


Ala Lys Gly Gln His Tyr Glu Leu Pro Thr Ser Phe Phe Lys Leu Val 
                85                  90                  95      


Leu Gly Lys His Leu Lys Tyr Ser Ser Ala Tyr Phe Ser Glu His Thr 
            100                 105                 110         


Arg Thr Leu Asp Glu Ala Glu Glu Ala Met Leu Ala Leu Tyr Cys Glu 
        115                 120                 125             


Arg Ala Lys Ile Glu Asp Gly Gln Lys Ile Leu Asp Ile Gly Cys Gly 
    130                 135                 140                 


Trp Gly Ser Phe Ser Leu Tyr Val Ala Glu Arg Tyr Pro Lys Cys Glu 
145                 150                 155                 160 


Ile Thr Gly Leu Cys Asn Ser Ser Thr Gln Lys Ala Phe Ile Glu Gln 
                165                 170                 175     


Gln Cys Ser Glu Arg Arg Leu Cys Asn Val Thr Ile Tyr Ala Asp Asp 
            180                 185                 190         


Ile Ser Thr Phe Asp Thr Glu Ser Thr Tyr Asp Arg Ile Ile Ser Ile 
        195                 200                 205             


Glu Met Phe Glu His Met Lys Asn Tyr Ser Thr Leu Leu Lys Lys Ile 
    210                 215                 220                 


Ser Lys Trp Met Asn Gln Glu Cys Leu Leu Phe Val His Tyr Phe Cys 
225                 230                 235                 240 


His Lys Thr Phe Ala Tyr His Phe Glu Asp Val Asp Glu Asp Asp Trp 
                245                 250                 255     


Met Ala Arg Tyr Phe Phe Thr Gly Gly Thr Met Pro Ala Ser Ser Leu 
            260                 265                 270         


Leu Leu Tyr Phe Gln Asp Asp Val Ser Val Val Asp His Trp Leu Ile 
        275                 280                 285             


Asn Gly Lys His Tyr Ala Gln Thr Ser Glu Glu Trp Leu Lys Arg Met 
    290                 295                 300                 


Asp His Asn Leu Ser Ser Ile Leu Pro Ile Phe Asn Glu Thr Tyr Gly 
305                 310                 315                 320 


Glu Asn Ala Ala Lys Lys Trp Leu Ala Tyr Trp Arg Thr Phe Phe Ile 
                325                 330                 335     


Ala Val Ala Glu Leu Phe Lys Tyr Asn Asp Gly Glu Glu Trp Met Val 
            340                 345                 350         


Ser His Phe Leu Phe Lys Lys Lys 
        355                 360 


<210>  4
<211>  1092
<212>  DNA
<213>  Sesamum indicum

<400>  4
atggcggagg ttaacggccg catcatcgat accattgtgc agatgcccta cgacgcaacc       60

gtacgtttta tgcttgcttc tctcgagcgc aacttgctgc ctgacgccgt tgtgcgccgc      120

ctcactcgtc tgcttctcgc tagtcgcctc cgctcaggat acagatcctc cgcggaactc      180

cagttgtccg acctccttca atttgcgcat tctttgagag aaatgccaat agcaatcaag      240

acggaaaagc caaagtctca gcactatgaa gttccaacgt cttacttcaa gcttgtcctt      300

ggaaagcatt taaaatacag ctgctgcttc tttcccaaca agtcgagcac cttagaggat      360

gctgagaagg caatgctaga gttatactgt gagaggtcac agataaaaga tggtcaatca      420

gtccttgatg ttggttgtgg ctggggatct ctttctatat acatagcaca gaagtacccc      480

aattgccagg ttacggggat ttgcaattca ataacccaga aagcacatat tgaggagcag      540

tgccgggaac ttcagttgca gaatgtggag ataattgtag cagatatcag cacatttgac      600

atggaagctt catatgacag aatattttcc attgaaatgt ttgagcatat gaaaaactat      660

caggatcttc ttaagaagat atcgaagtgg atgaaaccag acagttttct gtttgtccat      720

tatttttgcc ataaaacatt tgcttaccac tttgaggacg taaatgagga cgactggatc      780

actaggtact tctttactgg aggtacaatg ccttctgcaa acctgctcct ttattttcag      840

gacgatgtgt ctatagttaa tcattggctt gtgaacggca agcattatgc acagacaagc      900

gaggaatggc ttaagagaat ggaccagaac ttgaattcta taaagccaat aatggaatgc      960

acttatggca aagattcagc ggtcaaatgg acagtctact ggagaacatt tttcattgca     1020

gttgcagaat tatttggcta caacaatgga gaagagtgga tggttgctca tttccttttc     1080

aagaagaaat aa                                                         1092


<210>  5
<211>  363
<212>  PRT
<213>  Sesamum indicum

<400>  5

Met Ala Glu Val Asn Gly Arg Ile Ile Asp Thr Ile Val Gln Met Pro 
1               5                   10                  15      


Tyr Asp Ala Thr Val Arg Phe Met Leu Ala Ser Leu Glu Arg Asn Leu 
            20                  25                  30          


Leu Pro Asp Ala Val Val Arg Arg Leu Thr Arg Leu Leu Leu Ala Ser 
        35                  40                  45              


Arg Leu Arg Ser Gly Tyr Arg Ser Ser Ala Glu Leu Gln Leu Ser Asp 
    50                  55                  60                  


Leu Leu Gln Phe Ala His Ser Leu Arg Glu Met Pro Ile Ala Ile Lys 
65                  70                  75                  80  


Thr Glu Lys Pro Lys Ser Gln His Tyr Glu Val Pro Thr Ser Tyr Phe 
                85                  90                  95      


Lys Leu Val Leu Gly Lys His Leu Lys Tyr Ser Cys Cys Phe Phe Pro 
            100                 105                 110         


Asn Lys Ser Ser Thr Leu Glu Asp Ala Glu Lys Ala Met Leu Glu Leu 
        115                 120                 125             


Tyr Cys Glu Arg Ser Gln Ile Lys Asp Gly Gln Ser Val Leu Asp Val 
    130                 135                 140                 


Gly Cys Gly Trp Gly Ser Leu Ser Ile Tyr Ile Ala Gln Lys Tyr Pro 
145                 150                 155                 160 


Asn Cys Gln Val Thr Gly Ile Cys Asn Ser Ile Thr Gln Lys Ala His 
                165                 170                 175     


Ile Glu Glu Gln Cys Arg Glu Leu Gln Leu Gln Asn Val Glu Ile Ile 
            180                 185                 190         


Val Ala Asp Ile Ser Thr Phe Asp Met Glu Ala Ser Tyr Asp Arg Ile 
        195                 200                 205             


Phe Ser Ile Glu Met Phe Glu His Met Lys Asn Tyr Gln Asp Leu Leu 
    210                 215                 220                 


Lys Lys Ile Ser Lys Trp Met Lys Pro Asp Ser Phe Leu Phe Val His 
225                 230                 235                 240 


Tyr Phe Cys His Lys Thr Phe Ala Tyr His Phe Glu Asp Val Asn Glu 
                245                 250                 255     


Asp Asp Trp Ile Thr Arg Tyr Phe Phe Thr Gly Gly Thr Met Pro Ser 
            260                 265                 270         


Ala Asn Leu Leu Leu Tyr Phe Gln Asp Asp Val Ser Ile Val Asn His 
        275                 280                 285             


Trp Leu Val Asn Gly Lys His Tyr Ala Gln Thr Ser Glu Glu Trp Leu 
    290                 295                 300                 


Lys Arg Met Asp Gln Asn Leu Asn Ser Ile Lys Pro Ile Met Glu Cys 
305                 310                 315                 320 


Thr Tyr Gly Lys Asp Ser Ala Val Lys Trp Thr Val Tyr Trp Arg Thr 
                325                 330                 335     


Phe Phe Ile Ala Val Ala Glu Leu Phe Gly Tyr Asn Asn Gly Glu Glu 
            340                 345                 350         


Trp Met Val Ala His Phe Leu Phe Lys Lys Lys 
        355                 360             


<210>  6
<211>  1068
<212>  DNA
<213>  Brassica rapus

<400>  6
atggagagga ttgtcgaggt agcttatgga gcatccgtga aagcagtttt aacgttgttg       60

gagaagaatc tgctgccgga tgttgtcata aggctactaa cgcggctgct tctcgccggt      120

cgacttcgtt ccggttacaa acccacggcg gagctgcaac tttctgatct actccgtttc      180

gttaactcta taaaagagat gcctatagca ataaatactg agaagccgaa gacgcaacac      240

tatgaattac caaccgcttt cttcgaactt gttcttggaa gaaacatgaa atacagctca      300

tgttatttcc caaaggattc aagttgctta gaagaagcag aggaagcaat attggctcta      360

tattgcgaaa gagctaaagt ggaagatgga caaagtgttc tcgatgtcgg atgtggctgg      420

ggatctttgt ctttgtacat tgcccgcaag tatatcaatt gcaagttaac cggtctttgc      480

aactcaaaaa cacagaaagc atttatcgat gaccaatgca ggaaacttgg cattcaaaat      540

gtcgaaatca ttgttgggga taatagcact tttgagcatg aagggacata tgaccgagtg      600

ttctccatcg aaatgtttga gcatatgaaa aactatggag agcttctgaa gaaaattgga      660

agctggatga gggaagatag tcttctgttt gttcactatt tctgccataa gacatttgct      720

taccattttg aggatgtgca tgacgatgac tggatcacaa gatacttctt tagtggagga      780

acaatgccat cggcgaatct tctcctctat ttccaagacg atgtttcgat tgtggatcat      840

tggctcctaa acgggaagca ttatgcaagg accagtgagg agtggctcaa aagaatggac      900

aaggagatag ttgcaataaa ggagataatg gaaatgactt atgggaaaga ggaggcagtg      960

aagtggatgg tttactggag aaccttcttc atggcggttg ctgagctttt tggatacaac     1020

aatggagaag agtggatgat ttcacacttc ttattcaaga agaaatga                  1068


<210>  7
<211>  355
<212>  PRT
<213>  Brassica rapus

<400>  7

Met Glu Arg Ile Val Glu Val Ala Tyr Gly Ala Ser Val Lys Ala Val 
1               5                   10                  15      


Leu Thr Leu Leu Glu Lys Asn Leu Leu Pro Asp Val Val Ile Arg Leu 
            20                  25                  30          


Leu Thr Arg Leu Leu Leu Ala Gly Arg Leu Arg Ser Gly Tyr Lys Pro 
        35                  40                  45              


Thr Ala Glu Leu Gln Leu Ser Asp Leu Leu Arg Phe Val Asn Ser Ile 
    50                  55                  60                  


Lys Glu Met Pro Ile Ala Ile Asn Thr Glu Lys Pro Lys Thr Gln His 
65                  70                  75                  80  


Tyr Glu Leu Pro Thr Ala Phe Phe Glu Leu Val Leu Gly Arg Asn Met 
                85                  90                  95      


Lys Tyr Ser Ser Cys Tyr Phe Pro Lys Asp Ser Ser Cys Leu Glu Glu 
            100                 105                 110         


Ala Glu Glu Ala Ile Leu Ala Leu Tyr Cys Glu Arg Ala Lys Val Glu 
        115                 120                 125             


Asp Gly Gln Ser Val Leu Asp Val Gly Cys Gly Trp Gly Ser Leu Ser 
    130                 135                 140                 


Leu Tyr Ile Ala Arg Lys Tyr Ile Asn Cys Lys Leu Thr Gly Leu Cys 
145                 150                 155                 160 


Asn Ser Lys Thr Gln Lys Ala Phe Ile Asp Asp Gln Cys Arg Lys Leu 
                165                 170                 175     


Gly Ile Gln Asn Val Glu Ile Ile Val Gly Asp Asn Ser Thr Phe Glu 
            180                 185                 190         


His Glu Gly Thr Tyr Asp Arg Val Phe Ser Ile Glu Met Phe Glu His 
        195                 200                 205             


Met Lys Asn Tyr Gly Glu Leu Leu Lys Lys Ile Gly Ser Trp Met Arg 
    210                 215                 220                 


Glu Asp Ser Leu Leu Phe Val His Tyr Phe Cys His Lys Thr Phe Ala 
225                 230                 235                 240 


Tyr His Phe Glu Asp Val His Asp Asp Asp Trp Ile Thr Arg Tyr Phe 
                245                 250                 255     


Phe Ser Gly Gly Thr Met Pro Ser Ala Asn Leu Leu Leu Tyr Phe Gln 
            260                 265                 270         


Asp Asp Val Ser Ile Val Asp His Trp Leu Leu Asn Gly Lys His Tyr 
        275                 280                 285             


Ala Arg Thr Ser Glu Glu Trp Leu Lys Arg Met Asp Lys Glu Ile Val 
    290                 295                 300                 


Ala Ile Lys Glu Ile Met Glu Met Thr Tyr Gly Lys Glu Glu Ala Val 
305                 310                 315                 320 


Lys Trp Met Val Tyr Trp Arg Thr Phe Phe Met Ala Val Ala Glu Leu 
                325                 330                 335     


Phe Gly Tyr Asn Asn Gly Glu Glu Trp Met Ile Ser His Phe Leu Phe 
            340                 345                 350         


Lys Lys Lys 
        355 


<210>  8
<211>  1161
<212>  DNA
<213>  Erythranthe guttata

<400>  8
atgctgaaag ataaatcaca gcgaaaatac gcaactccgt catcttcagc tgacgattcc       60

acggtaacaa tggcggcagt taacggcggc attgtggatt cgattgtcca ggtgccctac      120

gaggccaccg tacgcctcat gctcggttcg ctcgagcgga atctgttgcc cgacgccgtc      180

gtgcgccgcc tcactcggct ccttctcgcc agtcgcctcc gctccggtta cagatcctcc      240

gccgacatcc agctgtccga tctcctcaat tttgtgcatt ctttgaaaga aatgccgata      300

gcaatccaga cagaaacgcc aaagtctcaa cattacgaag ttcctacatc tttcttcaag      360

cttgccctcg gcaaacatct caaatacagt tgctgctatt tttcagataa gtcaagcact      420

ttagacgatg ccgagaaggc aatgcttgag ttgtactgtg agagatcgca gataaaagac      480

ggtcattccg ttctcgatgt cggttgtggc tggggatctc tttccctata cattgctcag      540

aaatacccca attgcctgat caaagggatt tgcaattcca ttacccaaaa ggaacacatc      600

gaggagcagt gtcgggatct tcaagtaaag aatgtggaga tagttgttgg agatatcagc      660

acgtttgata tggaagcttc ttatgacaga atattttcca ttgaaatgtt tgagcatatg      720

aaaaactacc gtgatcttct taagaagata tccaagtgga tgaaatcgga cggtcttctg      780

ttcatccatt atttctgcca taaaacattt gcttaccact ttgaggatgt caacgaggac      840

gattggatca ctaggtactt ctttactgga ggtacaatgc cctcagcaga cctgctcctt      900

tactttcagg atgacgtttc tatagtcgat cactggcttg tgaatggcaa gcattatgca      960

cagacaagtg aagaatggct taagagaatg gaccagaatt tgagctcaat aaagccatta     1020

atggagtcca cttatggtaa agattcagct gtcaagtgga ccgtctattg gagaacattt     1080

ttcattgcgg ttgcggaatt gttcggctac aacaatggag aagaatggat ggttgctcat     1140

ttccttttca agaagaaata a                                               1161


<210>  9
<211>  386
<212>  PRT
<213>  Erythranthe guttata

<400>  9

Met Leu Lys Asp Lys Ser Gln Arg Lys Tyr Ala Thr Pro Ser Ser Ser 
1               5                   10                  15      


Ala Asp Asp Ser Thr Val Thr Met Ala Ala Val Asn Gly Gly Ile Val 
            20                  25                  30          


Asp Ser Ile Val Gln Val Pro Tyr Glu Ala Thr Val Arg Leu Met Leu 
        35                  40                  45              


Gly Ser Leu Glu Arg Asn Leu Leu Pro Asp Ala Val Val Arg Arg Leu 
    50                  55                  60                  


Thr Arg Leu Leu Leu Ala Ser Arg Leu Arg Ser Gly Tyr Arg Ser Ser 
65                  70                  75                  80  


Ala Asp Ile Gln Leu Ser Asp Leu Leu Asn Phe Val His Ser Leu Lys 
                85                  90                  95      


Glu Met Pro Ile Ala Ile Gln Thr Glu Thr Pro Lys Ser Gln His Tyr 
            100                 105                 110         


Glu Val Pro Thr Ser Phe Phe Lys Leu Ala Leu Gly Lys His Leu Lys 
        115                 120                 125             


Tyr Ser Cys Cys Tyr Phe Ser Asp Lys Ser Ser Thr Leu Asp Asp Ala 
    130                 135                 140                 


Glu Lys Ala Met Leu Glu Leu Tyr Cys Glu Arg Ser Gln Ile Lys Asp 
145                 150                 155                 160 


Gly His Ser Val Leu Asp Val Gly Cys Gly Trp Gly Ser Leu Ser Leu 
                165                 170                 175     


Tyr Ile Ala Gln Lys Tyr Pro Asn Cys Leu Ile Lys Gly Ile Cys Asn 
            180                 185                 190         


Ser Ile Thr Gln Lys Glu His Ile Glu Glu Gln Cys Arg Asp Leu Gln 
        195                 200                 205             


Val Lys Asn Val Glu Ile Val Val Gly Asp Ile Ser Thr Phe Asp Met 
    210                 215                 220                 


Glu Ala Ser Tyr Asp Arg Ile Phe Ser Ile Glu Met Phe Glu His Met 
225                 230                 235                 240 


Lys Asn Tyr Arg Asp Leu Leu Lys Lys Ile Ser Lys Trp Met Lys Ser 
                245                 250                 255     


Asp Gly Leu Leu Phe Ile His Tyr Phe Cys His Lys Thr Phe Ala Tyr 
            260                 265                 270         


His Phe Glu Asp Val Asn Glu Asp Asp Trp Ile Thr Arg Tyr Phe Phe 
        275                 280                 285             


Thr Gly Gly Thr Met Pro Ser Ala Asp Leu Leu Leu Tyr Phe Gln Asp 
    290                 295                 300                 


Asp Val Ser Ile Val Asp His Trp Leu Val Asn Gly Lys His Tyr Ala 
305                 310                 315                 320 


Gln Thr Ser Glu Glu Trp Leu Lys Arg Met Asp Gln Asn Leu Ser Ser 
                325                 330                 335     


Ile Lys Pro Leu Met Glu Ser Thr Tyr Gly Lys Asp Ser Ala Val Lys 
            340                 345                 350         


Trp Thr Val Tyr Trp Arg Thr Phe Phe Ile Ala Val Ala Glu Leu Phe 
        355                 360                 365             


Gly Tyr Asn Asn Gly Glu Glu Trp Met Val Ala His Phe Leu Phe Lys 
    370                 375                 380                 


Lys Lys 
385     


