                         SEQUENCE LISTING

<110>  UAB Research Foundation
       Townes, Tim
       Ding, Lei
       Chang, Chia-Wei
 
<120>  CRISPR/CAS9 COMPLEX FOR GENOMIC EDITING

<130>  035979-1014678 (177WO1)

<150>  US 62/181,138
<151>  2015-06-17

<150>  US 62/266,316
<151>  2015-12-11

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1
taacggcaga cttctccac                                                    19


<210>  2
<211>  103
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  2
gtaacggcag acttctccac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttt                        103


<210>  3
<211>  1671
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SEQ ID NO: 4

<400>  3

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu 
        35                  40                  45              


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    50                  55                  60                  


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
65                  70                  75                  80  


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                85                  90                  95      


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            100                 105                 110         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        115                 120                 125             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    130                 135                 140                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
145                 150                 155                 160 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                165                 170                 175     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            180                 185                 190         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        195                 200                 205             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    210                 215                 220                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
225                 230                 235                 240 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                245                 250                 255     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            260                 265                 270         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        275                 280                 285             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    290                 295                 300                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
305                 310                 315                 320 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                325                 330                 335     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            340                 345                 350         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        355                 360                 365             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    370                 375                 380                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
385                 390                 395                 400 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                405                 410                 415     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            420                 425                 430         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        435                 440                 445             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    450                 455                 460                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
465                 470                 475                 480 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                485                 490                 495     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            500                 505                 510         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        515                 520                 525             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    530                 535                 540                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
545                 550                 555                 560 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                565                 570                 575     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            580                 585                 590         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        595                 600                 605             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    610                 615                 620                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
625                 630                 635                 640 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                645                 650                 655     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            660                 665                 670         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        675                 680                 685             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    690                 695                 700                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
705                 710                 715                 720 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                725                 730                 735     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            740                 745                 750         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        755                 760                 765             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    770                 775                 780                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
785                 790                 795                 800 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                805                 810                 815     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            820                 825                 830         


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
        835                 840                 845             


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
    850                 855                 860                 


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
865                 870                 875                 880 


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
                885                 890                 895     


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
            900                 905                 910         


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
        915                 920                 925             


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
    930                 935                 940                 


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
                965                 970                 975     


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
            980                 985                 990         


Lys Val Ile Thr Leu Lys Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp 
        995                 1000                 1005             


Phe Gln  Phe Tyr Lys Val Arg  Glu Ile Asn Asn Tyr  His His Ala 
    1010                 1015                 1020             


His Asp  Ala Tyr Leu Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys 
    1040                 1045                 1050             


Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile 
    1055                 1060                 1065             


Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn 
    1070                 1075                 1080             


Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys 
    1085                 1090                 1095             


Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp 
    1100                 1105                 1110             


Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg Lys Val  Leu Ser Met 
    1115                 1120                 1125             


Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly 
    1130                 1135                 1140             


Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu 
    1145                 1150                 1155             


Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe 
    1160                 1165                 1170             


Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu Val Val  Ala Lys Val 
    1175                 1180                 1185             


Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu 
    1190                 1195                 1200             


Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile 
    1205                 1210                 1215             


Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu 
    1220                 1225                 1230             


Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly 
    1235                 1240                 1245             


Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn 
    1250                 1255                 1260             


Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala 
    1265                 1270                 1275             


Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1280                 1285                 1290             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1295                 1300                 1305             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1310                 1315                 1320             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1325                 1330                 1335             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1340                 1345                 1350             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1355                 1360                 1365             


Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp 
    1370                 1375                 1380             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1385                 1390                 1395             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr 
    1400                 1405                 1410             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys Gly Ser  Gly Ser Asn 
    1415                 1420                 1425             


Gly Ser  Ser Gly Ser Ala Ser  Lys Gly Glu Arg Leu  Phe Arg Gly 
    1430                 1435                 1440             


Lys Val  Pro Ile Leu Val Glu  Leu Lys Gly Asp Val  Asn Gly His 
    1445                 1450                 1455             


Lys Phe  Ser Val Arg Gly Lys  Gly Lys Gly Asp Ala  Thr Arg Gly 
    1460                 1465                 1470             


Lys Leu  Thr Leu Lys Phe Ile  Cys Thr Thr Gly Lys  Leu Pro Val 
    1475                 1480                 1485             


Pro Trp  Pro Thr Leu Val Thr  Thr Leu Thr Tyr Gly  Val Gln Cys 
    1490                 1495                 1500             


Phe Ser  Arg Tyr Pro Lys His  Met Lys Arg His Asp  Phe Phe Lys 
    1505                 1510                 1515             


Ser Ala  Met Pro Lys Gly Tyr  Val Gln Glu Arg Thr  Ile Ser Phe 
    1520                 1525                 1530             


Lys Lys  Asp Gly Lys Tyr Lys  Thr Arg Ala Glu Val  Lys Phe Glu 
    1535                 1540                 1545             


Gly Arg  Thr Leu Val Asn Arg  Ile Lys Leu Lys Gly  Arg Asp Phe 
    1550                 1555                 1560             


Lys Glu  Lys Gly Asn Ile Leu  Gly His Lys Leu Arg  Tyr Asn Phe 
    1565                 1570                 1575             


Asn Ser  His Lys Val Tyr Ile  Thr Ala Asp Lys Arg  Lys Asn Gly 
    1580                 1585                 1590             


Ile Lys  Ala Lys Phe Lys Ile  Arg His Asn Val Lys  Asp Gly Ser 
    1595                 1600                 1605             


Val Gln  Leu Ala Asp His Tyr  Gln Gln Asn Thr Pro  Ile Gly Arg 
    1610                 1615                 1620             


Gly Pro  Val Leu Leu Pro Arg  Asn His Tyr Leu Ser  Thr Arg Ser 
    1625                 1630                 1635             


Lys Leu  Ser Lys Asp Pro Lys  Glu Lys Arg Asp His  Met Val Leu 
    1640                 1645                 1650             


Leu Glu  Phe Val Thr Ala Ala  Gly Ile Lys His Gly  Arg Asp Glu 
    1655                 1660                 1665             


Arg Tyr  Lys 
    1670     


<210>  4
<211>  1720
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  4

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Ala Gly 
1               5                   10                  15      


Gly Ser Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
            20                  25                  30          


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg 
        35                  40                  45              


Lys Val Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile 
    50                  55                  60                  


Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
65                  70                  75                  80  


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
                85                  90                  95      


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
            100                 105                 110         


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
        115                 120                 125             


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
    130                 135                 140                 


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
145                 150                 155                 160 


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
                165                 170                 175     


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
            180                 185                 190         


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
        195                 200                 205             


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
    210                 215                 220                 


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
225                 230                 235                 240 


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
                245                 250                 255     


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
            260                 265                 270         


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
        275                 280                 285             


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
    290                 295                 300                 


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
305                 310                 315                 320 


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
                325                 330                 335     


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
            340                 345                 350         


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
        355                 360                 365             


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
    370                 375                 380                 


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
385                 390                 395                 400 


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
                405                 410                 415     


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
            420                 425                 430         


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
        435                 440                 445             


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
    450                 455                 460                 


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
465                 470                 475                 480 


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
                485                 490                 495     


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
            500                 505                 510         


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
        515                 520                 525             


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
    530                 535                 540                 


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
545                 550                 555                 560 


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
                565                 570                 575     


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
            580                 585                 590         


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
        595                 600                 605             


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
    610                 615                 620                 


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
625                 630                 635                 640 


Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 
                645                 650                 655     


Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 
            660                 665                 670         


Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
        675                 680                 685             


Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val 
    690                 695                 700                 


Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser 
705                 710                 715                 720 


Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile 
                725                 730                 735     


Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln 
            740                 745                 750         


Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala 
        755                 760                 765             


Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu 
    770                 775                 780                 


Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val 
785                 790                 795                 800 


Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile 
                805                 810                 815     


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys 
            820                 825                 830         


Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
        835                 840                 845             


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln 
    850                 855                 860                 


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
865                 870                 875                 880 


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
                885                 890                 895     


His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys 
            900                 905                 910         


Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro 
        915                 920                 925             


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
    930                 935                 940                 


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
945                 950                 955                 960 


Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg 
                965                 970                 975     


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu 
            980                 985                 990         


Asp Ser Arg Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
        995                 1000                 1005             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1010                 1015                 1020             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1025                 1030                 1035             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1040                 1045                 1050             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1055                 1060                 1065             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1070                 1075                 1080             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1085                 1090                 1095             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1100                 1105                 1110             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1115                 1120                 1125             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1130                 1135                 1140             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1145                 1150                 1155             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1160                 1165                 1170             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1175                 1180                 1185             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1190                 1195                 1200             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1205                 1210                 1215             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1220                 1225                 1230             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1235                 1240                 1245             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1250                 1255                 1260             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1265                 1270                 1275             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1280                 1285                 1290             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1295                 1300                 1305             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1310                 1315                 1320             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1325                 1330                 1335             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1340                 1345                 1350             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1355                 1360                 1365             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1370                 1375                 1380             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1385                 1390                 1395             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1400                 1405                 1410             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro 
    1415                 1420                 1425             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys Gly Ser 
    1430                 1435                 1440             


Gly Ser  Asn Gly Ser Ser Gly  Ser Ala Ser Lys Gly  Glu Arg Leu 
    1445                 1450                 1455             


Phe Arg  Gly Lys Val Pro Ile  Leu Val Glu Leu Lys  Gly Asp Val 
    1460                 1465                 1470             


Asn Gly  His Lys Phe Ser Val  Arg Gly Lys Gly Lys  Gly Asp Ala 
    1475                 1480                 1485             


Thr Arg  Gly Lys Leu Thr Leu  Lys Phe Ile Cys Thr  Thr Gly Lys 
    1490                 1495                 1500             


Leu Pro  Val Pro Trp Pro Thr  Leu Val Thr Thr Leu  Thr Tyr Gly 
    1505                 1510                 1515             


Val Gln  Cys Phe Ser Arg Tyr  Pro Lys His Met Lys  Arg His Asp 
    1520                 1525                 1530             


Phe Phe  Lys Ser Ala Met Pro  Lys Gly Tyr Val Gln  Glu Arg Thr 
    1535                 1540                 1545             


Ile Ser  Phe Lys Lys Asp Gly  Lys Tyr Lys Thr Arg  Ala Glu Val 
    1550                 1555                 1560             


Lys Phe  Glu Gly Arg Thr Leu  Val Asn Arg Ile Lys  Leu Lys Gly 
    1565                 1570                 1575             


Arg Asp  Phe Lys Glu Lys Gly  Asn Ile Leu Gly His  Lys Leu Arg 
    1580                 1585                 1590             


Tyr Asn  Phe Asn Ser His Lys  Val Tyr Ile Thr Ala  Asp Lys Arg 
    1595                 1600                 1605             


Lys Asn  Gly Ile Lys Ala Lys  Phe Lys Ile Arg His  Asn Val Lys 
    1610                 1615                 1620             


Asp Gly  Ser Val Gln Leu Ala  Asp His Tyr Gln Gln  Asn Thr Pro 
    1625                 1630                 1635             


Ile Gly  Arg Gly Pro Val Leu  Leu Pro Arg Asn His  Tyr Leu Ser 
    1640                 1645                 1650             


Thr Arg  Ser Lys Leu Ser Lys  Asp Pro Lys Glu Lys  Arg Asp His 
    1655                 1660                 1665             


Met Val  Leu Leu Glu Phe Val  Thr Ala Ala Gly Ile  Lys His Gly 
    1670                 1675                 1680             


Arg Asp  Glu Arg Tyr Lys Gly  Gly Ser Gly Gly Ser  Val Asp Gly 
    1685                 1690                 1695             


Leu Phe  Glu Ala Ile Glu Gly  Phe Ile Glu Asn Gly  Trp Glu Gly 
    1700                 1705                 1710             


Met Ile  Asp Gly Trp Tyr Gly  
    1715                 1720 


<210>  5
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5
gctaattcac tcccaaagaa gacaag                                            26


<210>  6
<211>  20
<212>  DNA
<213>  Synthetic construct

<400>  6
cttcagcaag ccgagtcctg                                                   20


<210>  7
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7
gtcgacgtcg acgctcagtg aagctgaagt attccttctg cttcacaggg cgaccactac       60


<210>  8
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8
atttaaatcc tcccctcgaa cccttaccaa actcctatgc atactacag                   49


<210>  9
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  9
ttaattaatt aattagcatt ttaggttcag gttgtgagaa cactagaaga gaacaagtca       60


<210>  10
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10
gtatacgtat acgcatacct ggagagggga caaggtcttg agatgcgagg gt               52


<210>  11
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11
agccacctta attaagccac catggcgcac gctgggagaa cggggtacga ta               52


<210>  12
<211>  60
<212>  DNA
<213>  Synthetic construct

<400>  12
taacagagag aagttcgtgg ctccggatcc cttgtggccc agataggcac ccagggtgat       60


<210>  13
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13
caccgtgaga tacagataca gaca                                              24


<210>  14
<211>  24
<212>  DNA
<213>  ARtificial sequence

<220>
<223>  Synthetic construct

<400>  14
aaactgtctg tatctgtatc tcac                                              24


<210>  15
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  15
aaacggcatt ccaggcaaat cattc                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16
caccgcagcc taggcaaagg cctgc                                             25


<210>  17
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  17
aaacgcaggc ctttgcctag gctgc                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  18
caccgtgcca acagaactgc ctgat                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  19
aaacatcagg cagttctgtt ggcac                                             25


<210>  20
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  20
caccgaccag ggtgcaagtg tgga                                              24


<210>  21
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  21
aaactccaca cttgcaccct ggtc                                              24


<210>  22
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  22
caccgctcct cagcctggca ttca                                              24


<210>  23
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  23
aaactgaatg ccaggctgag gagc                                              24


<210>  24
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  24
tgctaaagcg catgctccag act                                               23


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  25
gtcttcatct cagggtcggc t                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  26
cctctctgtg cattatggca g                                                 21


<210>  27
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  27
gccttctatc gccttcttg                                                    19


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  28
actcctccac ctttgacgct                                                   20


<210>  29
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  29
tcccctcttc aagggtctac atg                                               23


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  30
gtgcaaaatg gaagggtttc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  31
ggagctccgt gaagttgttc                                                   20


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  32
tgtttccttt cactggccac a                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  33
aacggcaact ggtgaacggt a                                                 21


<210>  34
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  34
ggcgatgcca gaatagatgc cg                                                22


<210>  35
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  35
ccaggccact tggctcctct atctccaga                                         29


<210>  36
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  36
ccttactgtt gagactgcaa tatcc                                             25


<210>  37
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  37
ctgaagtccc agtatatact tcacac                                            26


<210>  38
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  38
cccagaagca gtaataatca tcgag                                             25


<210>  39
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  39
atgtgggatg tagtagatct tgc                                               23


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  40
gggtcttacc tcagcagtta c                                                 21


<210>  41
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  41
cctcacacag tgtgacgcag                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  42
gactgagtac ctgaaccggc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  43
gggccaaact gagcagagtc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  44
aagaccaggg tggttgggac                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  45
gtaagaaaaa tgcccacgtc                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artifiical sequence

<400>  46
agtcagacgt ctggagcttc                                                   20


<210>  47
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  47
gtgagcagtg aaggcatgag tc                                                22


<210>  48
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  48
gtgagataca gatacagaca                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  49
aatgatttgc ctggaatgcc                                                   20


<210>  50
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  50

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210>  51
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  51

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10                  


<210>  52
<211>  91
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  52
atccacgttc accttgcccc acagggcagt aacggcagac ttctcctcag gagtcaggtg       60

caccatggtg tctgtttgag gttgctagtg a                                      91


<210>  53
<211>  95
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  53
cttcatccac gttcaccttg ccccacaggg cagtaacggc agatttttcc tcaggagtca       60

ggtgcaccat ggtgtctgtt tgaggttgct agtga                                  95


<210>  54
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  54
taatacgact cactataggg taacggcaga cttctccac                              39


<210>  55
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  55
aaaaagcacc gactcggtgc c                                                 21


<210>  56
<211>  14
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  56
tcctgaggaa aaat                                                         14


<210>  57
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  57
tgactcctga ggagaa                                                       16


<210>  58
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  58
actcctgtgg agaag                                                        15


<210>  59
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  59
cagagccatc tattgcttac atttg                                             25


<210>  60
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  60
ggcctcacca ccaacttcat                                                   20


<210>  61
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  61

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Ala Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg 
            20                  25                  30          


Arg Pro Pro Gln Ala Gly Gly Gly Ser Gly Gly Ser Tyr Gly Arg Lys 
        35                  40                  45              


Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Ala Gly 
    50                  55                  60  


<210>  62
<211>  104
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  62
gggucugccg uuacugcccu gguuuuagag cuagaaauag caaguuaaaa uaaggcuagu       60

ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu uuuu                       104


<210>  63
<211>  105
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  63
ggguaacggc agacuucucc acguuuuaga gcuagaaaua gcaaguuaaa auaaggcuag       60

uccguuauca acuugaaaaa guggcaccga gucggugcuu uuuuu                      105


<210>  64
<211>  90
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  64
acctcaaaca gacaccatgg tgcacctgac tcctgaggag aagtctgccg tcacagctct       60

gtggggcaag gtgaacgtgg atgaagttgg                                        90


<210>  65
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  65
taatacgact cactataggg tctgccgtta ctgccctg                               38


<210>  66
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  66
tccacatgcc cagtttctat                                                   20


<210>  67
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  67
agtagcaatt tgtactgatg gtatg                                             25


<210>  68
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  68
ggtctgccgt tactgccctg                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  69
gtaacggcag acttctccac                                                   20


