                               SEQUENCE LISTING

<110> AMGEN INC.
      SANTA MARIA BIOTHERAPEUTICS, INC.
 
<120> FORMULATED RECEPTOR POLYPEPTIDES AND RELATED METHODS

<130> 29957-29502 PCT

<140> 
<141> 

<150> 62/142,812
<151> 2015-04-03

<150> 62/058,789
<151> 2014-10-02

<150> 62/047,995
<151> 2014-09-09

<150> 61/012,104
<151> 2014-06-13

<160> 53    

<170> PatentIn version 3.5

<210> 1
<211> 402
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(402)

<400> 1
atg acg gcg ccc tgg gtg gcc ctc gcc ctc ctc tgg gga tcg ctg tgc       48
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys         
1               5                   10                  15              

gcc ggc tct ggg cgt ggg gag gct gag aca cgg gag tgc atc tac tac       96
Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr         
            20                  25                  30                  

aac gcc aac tgg gag ctg gag cgc acc aac cag agc ggc ctg gag cgc      144
Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg         
        35                  40                  45                      

tgc gaa ggc gag cag gac aag cgg ctg cac tgc tac gcc tcc tgg cgc      192
Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg         
    50                  55                  60                          

aac agc tct ggc acc atc gag ctc gtg aag aag ggc tgc tgg cta gat      240
Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp         
65                  70                  75                  80          

gac ttc aac tgc tac gat agg cag gag tgt gtg gcc act gag gag aac      288
Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn         
                85                  90                  95              

ccc cag gtg tac ttc tgc tgc tgt gaa ggc aac ttc tgc aac gag cgc      336
Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg         
            100                 105                 110                 

ttc act cat ttg cca gag gct ggg ggc ccg gaa gtc acg tac gag cca      384
Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro         
        115                 120                 125                     

ccc ccg aca gcc ccc acc                                              402
Pro Pro Thr Ala Pro Thr                                                 
    130                                                                 


<210> 2
<211> 134
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      

Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          

Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              

Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  

Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  

Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      

Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         

Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             

Pro Pro Thr Ala Pro Thr 
    130                 


<210> 3
<211> 387
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(387)

<400> 3
atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt       48

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly         
1               5                   10                  15              

gtc cag tgt gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag       96
Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu         
            20                  25                  30                  

ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag      144
Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln         
        35                  40                  45                      

gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc      192
Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr         
    50                  55                  60                          

atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac      240
Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr         
65                  70                  75                  80          

gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc      288
Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe         
                85                  90                  95              

tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca      336
Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro         
            100                 105                 110                 

gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc      384
Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro         
        115                 120                 125                     

acc                                                                  387
Thr                                                                     
                                                                        


<210> 4
<211> 129
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      

Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 
            20                  25                  30          

Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 
        35                  40                  45              

Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 
    50                  55                  60                  

Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
65                  70                  75                  80  

Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 
                85                  90                  95      

Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 
            100                 105                 110         

Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
        115                 120                 125             

Thr 
    


<210> 5
<211> 330
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(330)

<400> 5
gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc       48
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg         
1               5                   10                  15              

acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg       96
Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg         
            20                  25                  30                  

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc      144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu         
        35                  40                  45                      

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag      192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln         
    50                  55                  60                          

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt      240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys         
65                  70                  75                  80          

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg      288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly         
                85                  90                  95              

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc              330
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr                 
            100                 105                 110                 


<210> 6
<211> 110
<212> PRT
<213> Homo sapiens

<400> 6
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      

Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          

Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              

Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  

Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  

Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      

Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210> 7
<211> 1071
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(1071)

<400> 7
atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt       48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly         
1               5                   10                  15              

gtc cag tgt gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag       96
Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu         
            20                  25                  30                  

ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag      144
Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln         
        35                  40                  45                      

gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc      192
Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr         
    50                  55                  60                          

atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac      240
Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr         
65                  70                  75                  80          

gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc      288
Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe         
                85                  90                  95              

tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca      336
Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro         
            100                 105                 110                 

gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc      384
Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro         
        115                 120                 125                     

acc gga ggg gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct      432

Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro         
    130                 135                 140                         

gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc      480
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr         
145                 150                 155                 160         

ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg      528
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val         
                165                 170                 175             

agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg      576
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val         
            180                 185                 190                 

gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc      624
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser         
        195                 200                 205                     

acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg      672
Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu         
    210                 215                 220                         

aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc      720
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala         
225                 230                 235                 240         

ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca      768
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro         
                245                 250                 255             

cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag      816
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln         
            260                 265                 270                 

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc      864
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala         
        275                 280                 285                     

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca      912
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr         
    290                 295                 300                         

cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc      960
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu         
305                 310                 315                 320         

acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc     1008
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser         
                325                 330                 335             

gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc     1056
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser         
            340                 345                 350                 

ctg tct ccg ggt aaa                                                 1071
Leu Ser Pro Gly Lys                                                     
        355                                                             


<210> 8
<211> 357
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      

Val Gln Cys Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 
            20                  25                  30          

Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 
        35                  40                  45              

Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 
    50                  55                  60                  

Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
65                  70                  75                  80  

Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 
                85                  90                  95      

Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 
            100                 105                 110         

Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
        115                 120                 125             

Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
    130                 135                 140                 

Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     

Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
        195                 200                 205             

Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
    210                 215                 220                 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
225                 230                 235                 240 

Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     

Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 

Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         

Leu Ser Pro Gly Lys 
        355         


<210> 9
<211> 1014
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(1014)

<400> 9
gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc       48
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg         
1               5                   10                  15              

acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg       96
Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg         
            20                  25                  30                  

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc      144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu         
        35                  40                  45                      

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag      192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln         
    50                  55                  60                          

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt      240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys         
65                  70                  75                  80          

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg      288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly         
                85                  90                  95              

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga ggg      336
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly         
            100                 105                 110                 

gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga      384
Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly         
        115                 120                 125                     

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc      432
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
    130                 135                 140                         

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa      480
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
145                 150                 155                 160         

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat      528
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
                165                 170                 175             

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt      576
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg         
            180                 185                 190                 

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag      624
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys         
        195                 200                 205                     

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag      672
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu         
    210                 215                 220                         

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac      720
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
225                 230                 235                 240         

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg      768
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
                245                 250                 255             

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg      816
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
            260                 265                 270                 

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg      864
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met         
        275                 280                 285                     

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac      912
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
    290                 295                 300                         

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat      960
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
305                 310                 315                 320         

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1008
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
                325                 330                 335             

ggt aaa                                                             1014
Gly Lys                                                                 
                                                                        


<210> 10
<211> 338
<212> PRT
<213> Homo sapiens

<400> 10
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      

Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          

Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              

Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  

Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  

Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      

Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 
            100                 105                 110         

Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
        115                 120                 125             

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 

Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
            180                 185                 190         

Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             

Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 

Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
        275                 280                 285             

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     

Gly Lys 
        


<210> 11
<211> 387
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(387)

<400> 11
atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt       48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly         
1               5                   10                  15              

gtc cag tgt gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag       96
Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu         
            20                  25                  30                  

ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag      144
Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln         
        35                  40                  45                      

gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc      192
Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr         
    50                  55                  60                          

atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac      240
Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr         
65                  70                  75                  80          

gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc      288
Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe         
                85                  90                  95              

tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca      336
Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro         
            100                 105                 110                 

gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc      384
Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro         
        115                 120                 125                     

acc                                                                  387
Thr                                                                     
                                                                        


<210> 12
<211> 129
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      

Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 
            20                  25                  30          

Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 
        35                  40                  45              

Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 
    50                  55                  60                  

Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
65                  70                  75                  80  

Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 
                85                  90                  95      

Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 
            100                 105                 110         

Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
        115                 120                 125             

Thr 
    


<210> 13
<211> 330
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(330)

<400> 13
gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag ctg gag cgc       48
Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg         
1               5                   10                  15              

acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg       96
Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg         
            20                  25                  30                  

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc      144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu         
        35                  40                  45                      

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag      192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln         
    50                  55                  60                          

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt      240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys         
65                  70                  75                  80          

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg      288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly         
                85                  90                  95              

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc              330
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr                 
            100                 105                 110                 


<210> 14
<211> 110
<212> PRT
<213> Homo sapiens

<400> 14
Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      

Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          

Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              

Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  

Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  

Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      

Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210> 15
<211> 1071
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(1071)

<400> 15
atg gag ttt ggg ctg agc tgg gtt ttc ctc gtt gct ctt tta aga ggt       48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly         
1               5                   10                  15              

gtc cag tgt gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag       96
Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu         
            20                  25                  30                  

ctg gag cgc acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag      144
Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln         
        35                  40                  45                      

gac aag cgg ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc      192
Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr         
    50                  55                  60                          

atc gag ctc gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac      240
Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr         
65                  70                  75                  80          

gat agg cag gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc      288
Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe         
                85                  90                  95              

tgc tgc tgt gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca      336
Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro         
            100                 105                 110                 

gag gct ggg ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc      384
Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro         
        115                 120                 125                     

acc gga ggg gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct      432
Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro         
    130                 135                 140                         

gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc      480
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr         
145                 150                 155                 160         

ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg      528
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val         
                165                 170                 175             

agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg      576
Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val         
            180                 185                 190                 

gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc      624
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser         
        195                 200                 205                     

acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg      672
Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu         
    210                 215                 220                         

aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc      720
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala         
225                 230                 235                 240         

ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca      768
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro         
                245                 250                 255             

cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag      816
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln         
            260                 265                 270                 

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc      864
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala         
        275                 280                 285                     

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca      912
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr         
    290                 295                 300                         

cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc      960
Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu         
305                 310                 315                 320         

acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc     1008
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser         
                325                 330                 335             

gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc     1056
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser         
            340                 345                 350                 

ctg tct ccg ggt aaa                                                 1071
Leu Ser Pro Gly Lys                                                     
        355                                                             


<210> 16
<211> 357
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      

Val Gln Cys Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu 
            20                  25                  30          

Leu Glu Arg Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln 
        35                  40                  45              

Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr 
    50                  55                  60                  

Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr 
65                  70                  75                  80  

Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe 
                85                  90                  95      

Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro 
            100                 105                 110         

Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
        115                 120                 125             

Thr Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
    130                 135                 140                 

Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     

Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
        195                 200                 205             

Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
    210                 215                 220                 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
225                 230                 235                 240 

Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     

Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 

Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         

Leu Ser Pro Gly Lys 
        355         


<210> 17
<211> 1014
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(1014)

<400> 17
gag aca cgg tac tgc atc tac tac aac gcc aac tgg gag ctg gag cgc       48
Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg         
1               5                   10                  15              

acc aac cag acc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg       96
Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg         
            20                  25                  30                  

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc      144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu         
        35                  40                  45                      

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag      192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln         
    50                  55                  60                          

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt      240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys         
65                  70                  75                  80          

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg      288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly         
                85                  90                  95              

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga ggg      336
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly         
            100                 105                 110                 

gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga      384
Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly         
        115                 120                 125                     

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc      432
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
    130                 135                 140                         

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa      480
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
145                 150                 155                 160         

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat      528
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
                165                 170                 175             

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt      576
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg         
            180                 185                 190                 

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag      624
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys         
        195                 200                 205                     

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag      672
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu         
    210                 215                 220                         

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac      720
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
225                 230                 235                 240         

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg      768
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
                245                 250                 255             

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg      816
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
            260                 265                 270                 

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg      864
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met         
        275                 280                 285                     

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac      912
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
    290                 295                 300                         

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat      960
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
305                 310                 315                 320         

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1008
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
                325                 330                 335             

ggt aaa                                                             1014
Gly Lys                                                                 
                                                                        


<210> 18
<211> 338
<212> PRT
<213> Homo sapiens

<400> 18
Glu Thr Arg Tyr Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      

Thr Asn Gln Thr Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          

Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              

Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  

Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  

Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      

Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 
            100                 105                 110         

Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
        115                 120                 125             

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 

Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
            180                 185                 190         

Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             

Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 

Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
        275                 280                 285             

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     

Gly Lys 
        


<210> 19
<211> 110
<212> PRT
<213> Homo sapiens

<400> 19
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      

Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          

Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              

Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  

Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  

Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      

Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr 
            100                 105                 110 


<210> 20
<211> 1014
<212> DNA
<213> Homo sapiens

<220>
<221> CDS
<222> (1)..(1014)

<400> 20
gag aca cgg tgg tgc atc tac tac aac gcc aac tgg gag ctg gag cgc       48
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg         
1               5                   10                  15              

acc aac cag agc ggc ctg gag cgc tgc gaa ggc gag cag gac aag cgg       96
Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg         
            20                  25                  30                  

ctg cac tgc tac gcc tcc tgg cgc aac agc tct ggc acc atc gag ctc      144
Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu         
        35                  40                  45                      

gtg aag aag ggc tgc tgg cta gat gac ttc aac tgc tac gat agg cag      192
Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln         
    50                  55                  60                          

gag tgt gtg gcc act gag gag aac ccc cag gtg tac ttc tgc tgc tgt      240
Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys         
65                  70                  75                  80          

gag ggc aac ttc tgc aac gag cgc ttc act cat ttg cca gag gct ggg      288
Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly         
                85                  90                  95              

ggc ccg gaa gtc acg tac gag cca ccc ccg aca gcc ccc acc gga gga      336
Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly         
            100                 105                 110                 

gga gga tct gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga      384
Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly         
        115                 120                 125                     

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc      432
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile         
    130                 135                 140                         

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa      480
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu         
145                 150                 155                 160         

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc gtg gag gtg cat      528
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His         
                165                 170                 175             

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt      576
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg         
            180                 185                 190                 

gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg ctg aac ggc aag      624
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys         
        195                 200                 205                     

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag      672
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu         
    210                 215                 220                         

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac      720
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr         
225                 230                 235                 240         

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg      768
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu         
                245                 250                 255             

acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg gag tgg      816
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp         
            260                 265                 270                 

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg      864
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met         
        275                 280                 285                     

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac      912
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp         
    290                 295                 300                         

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat      960
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His         
305                 310                 315                 320         

gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg tct ccg     1008
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro         
                325                 330                 335             

ggt aaa                                                             1014
Gly Lys                                                                 
                                                                        


<210> 21
<211> 338
<212> PRT
<213> Homo sapiens

<400> 21
Glu Thr Arg Trp Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg 
1               5                   10                  15      

Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg 
            20                  25                  30          

Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu 
        35                  40                  45              

Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln 
    50                  55                  60                  

Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys 
65                  70                  75                  80  

Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu Ala Gly 
                85                  90                  95      

Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Thr Gly Gly 
            100                 105                 110         

Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
        115                 120                 125             

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 

Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
            180                 185                 190         

Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             

Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 

Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
        275                 280                 285             

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     

Gly Lys 
        


<210> 22
<211> 216
<212> PRT
<213> Homo sapiens

<400> 22
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          

Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            100                 105                 110         

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        115                 120                 125             

Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 

Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             

Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210> 23
<211> 217
<212> PRT
<213> Homo sapiens

<400> 23
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      

Pro Lys Asp Ile Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              

Val Gly Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  

Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             

Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 24
<211> 217
<212> PRT
<213> Homo sapiens

<400> 24
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          

Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  

Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      

Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             

Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210> 25
<211> 5
<212> PRT
<213> Artificial

<220>
<223> Linker

<400> 25
Gly Gly Gly Gly Ser 
1               5   


<210> 26
<211> 36
<212> DNA
<213> Artificial

<220>
<223> Hinge linker


<220>
<221> CDS
<222> (1)..(36)

<400> 26
gga ggg gga gga tct gtc gag tgc cca ccg tgc cca                       36
Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro                         
1               5                   10                                  


<210> 27
<211> 12
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 27
Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210> 28
<211> 12
<212> PRT
<213> Homo sapiens

<400> 28
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210> 29
<211> 15
<212> PRT
<213> Homo sapiens

<400> 29
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210> 30
<211> 12
<212> PRT
<213> Homo sapiens

<400> 30
Glu Ser Lys Thr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210> 31
<211> 18
<212> PRT
<213> Homo sapiens

<400> 31
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Trp 
1               5                   10                  15      


Pro Gly 
        


<210> 32
<211> 18
<212> PRT
<213> Homo sapiens

<400> 32
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      


Ala Gly 
        


<210> 33
<211> 512
<212> PRT
<213> Homo sapiens

<400> 33
Met Thr Ala Pro Trp Val Ala Leu Ala Leu Leu Trp Gly Ser Leu Cys 
1               5                   10                  15      

Ala Gly Ser Gly Arg Gly Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr 
            20                  25                  30          
Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg 
        35                  40                  45              

Cys Glu Gly Glu Gln Asp Lys Arg Leu His Cys Tyr Ala Ser Trp Arg 
    50                  55                  60                  

Asn Ser Ser Gly Thr Ile Glu Leu Val Lys Lys Gly Cys Trp Leu Asp 
65                  70                  75                  80  

Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys Val Ala Thr Glu Glu Asn 
                85                  90                  95      

Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg 
            100                 105                 110         

Phe Thr His Leu Pro Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro 
        115                 120                 125             

Pro Pro Thr Ala Pro Thr Leu Leu Thr Val Leu Ala Tyr Ser Leu Leu 
    130                 135                 140                 

Pro Ile Gly Gly Leu Ser Leu Ile Val Leu Leu Ala Phe Trp Met Tyr 
145                 150                 155                 160 

Arg His Arg Lys Pro Pro Tyr Gly His Val Asp Ile His Glu Asp Pro 
                165                 170                 175     

Gly Pro Pro Pro Pro Ser Pro Leu Val Gly Leu Lys Pro Leu Gln Leu 
            180                 185                 190         

Leu Glu Ile Lys Ala Arg Gly Arg Phe Gly Cys Val Trp Lys Ala Gln 
        195                 200                 205             

Leu Met Asn Asp Phe Val Ala Val Lys Ile Phe Pro Leu Gln Asp Lys 
    210                 215                 220                 

Gln Ser Trp Gln Ser Glu Arg Glu Ile Phe Ser Thr Pro Gly Met Lys 
225                 230                 235                 240 

His Glu Asn Leu Leu Gln Phe Ile Ala Ala Glu Lys Arg Gly Ser Asn 
                245                 250                 255     

Leu Glu Val Glu Leu Trp Leu Ile Thr Ala Phe His Asp Lys Gly Ser 
            260                 265                 270         

Leu Thr Asp Tyr Leu Lys Gly Asn Ile Ile Thr Trp Asn Glu Leu Cys 
        275                 280                 285             

His Val Ala Glu Thr Met Ser Arg Gly Leu Ser Tyr Leu His Glu Asp 
    290                 295                 300                 

Val Pro Trp Cys Arg Gly Glu Gly His Lys Pro Ser Ile Ala His Arg 
305                 310                 315                 320 

Asp Phe Lys Ser Lys Asn Val Leu Leu Lys Ser Asp Leu Thr Ala Val 
                325                 330                 335     

Leu Ala Asp Phe Gly Leu Ala Val Arg Phe Glu Pro Gly Lys Pro Pro 
            340                 345                 350         

Gly Asp Thr His Gly Gln Val Gly Thr Arg Arg Tyr Met Ala Pro Glu 
        355                 360                 365             

Val Leu Glu Gly Ala Ile Asn Phe Gln Arg Asp Ala Phe Leu Arg Ile 
    370                 375                 380                 

Asp Met Tyr Ala Met Gly Leu Val Leu Trp Glu Leu Val Ser Arg Cys 
385                 390                 395                 400 

Lys Ala Ala Asp Gly Pro Val Asp Glu Tyr Met Leu Pro Phe Glu Glu 
                405                 410                 415     

Glu Ile Gly Gln His Pro Ser Leu Glu Glu Leu Gln Glu Val Val Val 
            420                 425                 430         

His Lys Lys Met Arg Pro Thr Ile Lys Asp His Trp Leu Lys His Pro 
        435                 440                 445             

Gly Leu Ala Gln Leu Cys Val Thr Ile Glu Glu Cys Trp Asp His Asp 
    450                 455                 460                 

Ala Glu Ala Arg Leu Ser Ala Gly Cys Val Glu Glu Arg Val Ser Leu 
465                 470                 475                 480 

Ile Arg Arg Ser Val Asn Gly Thr Thr Ser Asp Cys Leu Val Ser Leu 
                485                 490                 495     

Val Thr Ser Val Thr Asn Val Asp Leu Pro Pro Lys Glu Ser Ser Ile 
            500                 505                 510         


<210> 34
<211> 426
<212> PRT
<213> Homo sapiens

<400> 34
Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      

Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          

Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              

Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  

Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  

Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      

Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         

Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             

Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 

Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 

Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     

Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         

Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             

Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 

Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 

Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     

Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         

Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             

His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 

His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 

Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     

Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         

Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             

His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 

Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 

Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     

Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210> 35
<211> 375
<212> PRT
<213> Homo sapiens

<400> 35
Met Gln Lys Leu Gln Leu Cys Val Tyr Ile Tyr Leu Phe Met Leu Ile 
1               5                   10                  15      

Val Ala Gly Pro Val Asp Leu Asn Glu Asn Ser Glu Gln Lys Glu Asn 
            20                  25                  30          

Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr 
        35                  40                  45              

Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu 
    50                  55                  60                  

Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Val Ile Arg Gln Leu 
65                  70                  75                  80  

Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val 
                85                  90                  95      

Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr His 
            100                 105                 110         

Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe Leu 
        115                 120                 125             

Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser 
    130                 135                 140                 

Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr Leu 
145                 150                 155                 160 

Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg Leu 
                165                 170                 175     

Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu 
            180                 185                 190         

Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp Val 
        195                 200                 205             

Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly 
    210                 215                 220                 

Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val Thr 
225                 230                 235                 240 

Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val Lys 
                245                 250                 255     

Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys 
            260                 265                 270         

Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
        275                 280                 285             

Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
    290                 295                 300                 

Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln Lys 
305                 310                 315                 320 

Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser Ala 
                325                 330                 335     

Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
            340                 345                 350         

Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met Val 
        355                 360                 365             

Val Asp Arg Cys Gly Cys Ser 
    370                 375 


<210> 36
<211> 217
<212> PRT
<213> Homo sapiens

<400> 36
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      

Pro Lys Asp Ile Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              

Val Gly Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  

Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             

Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 37
<211> 48
<212> DNA
<213> Artificial

<220>
<223> Hinge linker

<220>
<221> CDS
<222> (1)..(48)

<400> 37
gga ggg gga gga tct gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc       48
Gly Gly Gly Gly Ser Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys         
1               5                   10                  15              


<210> 38
<211> 16
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 38
Gly Gly Gly Gly Ser Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
1               5                   10                  15      


<210> 39
<211> 42
<212> DNA
<213> Artificial

<220>
<223> Hinge linker


<220>
<221> CDS
<222> (1)..(42)

<400> 39
gga ggg gga gga tct ggt gga ggt ggt tca ggt cca ccg tgc               42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Cys                 
1               5                   10                                  


<210> 40
<211> 14
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 40
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Cys 
1               5                   10                  


<210> 41
<211> 42
<212> DNA
<213> Artificial

<220>
<223> Hinge linker


<220>
<221> CDS
<222> (1)..(42)

<400> 41
gga ggg gga gga tct ggt gga ggt ggt tca ggt cca ccg gga               42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Gly                 
1               5                   10                                  


<210> 42
<211> 14
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro Gly 
1               5                   10                  


<210> 43
<211> 54
<212> DNA
<213> Artificial

<220>
<223> Hinge linker


<220>
<221> CDS
<222> (1)..(54)

<400> 43
gga ggg gga gga tct gag cgc aaa tgt cca cct tgt gtc gag tgc cca       48
Gly Gly Gly Gly Ser Glu Arg Lys Cys Pro Pro Cys Val Glu Cys Pro         
1               5                   10                  15              

ccg tgc                                                               54
Pro Cys                                                                 
                                                                        


<210> 44
<211> 18
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 44
Gly Gly Gly Gly Ser Glu Arg Lys Cys Pro Pro Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys 
        


<210> 45
<211> 14
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 45
Gly Pro Ala Ser Gly Gly Pro Ala Ser Gly Pro Pro Cys Pro 
1               5                   10                  


<210> 46
<211> 21
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 46
Gly Pro Ala Ser Gly Gly Pro Ala Ser Gly Cys Pro Pro Cys Val Glu 
1               5                   10                  15      

Cys Pro Pro Cys Pro 
            20      


<210> 47
<211> 217
<212> PRT
<213> Homo sapiens

<400> 47
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  

Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             

Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 48
<211> 16
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 48
Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210> 49
<211> 16
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 49
Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr Gly Pro Pro Cys Pro 
1               5                   10                  15      


<210> 50
<211> 21
<212> PRT
<213> Artificial

<220>
<223> Hinge linker

<400> 50
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Asp Lys Thr His Thr 
1               5                   10                  15      


Gly Pro Pro Cys Pro 
            20      


<210> 51
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Gly Gly Gly Gly Gly 
1               5   


<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 53
<211> 300
<212> DNA
<213> Homo sapiens

<400> 53
gagacacggt ggtgcatcta ctacaacgcc aactgggagc tggagcgcac caaccagacc       60

ggcctggagc gctgcgaagg cgagcaggac aagcggctgc actgctacgc ctcctggcgc      120

aacagctctg gcaccatcga gctcgtgaag aagggctgct ggctagatga cttcaactgc      180

tacgataggc aggagtgtgt ggccactgag gagaaccccc aggtgtactt ctgctgctgt      240

gagggcaact tctgcaacga gcgcttcact catttgccag aggctggggg cccggaagtc      300


