                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  NON-HORMONAL MAMMALIAN SPERM DECOY CONTRACEPTION BASED ON THE 
       N-TERMINUS OF THE ZP2 PROTEIN

<130>  4239-95114-02

<150>  US 62/175,821
<151>  2015-06-15

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
ggtttctttc cctcttattc acccttgtga cttcagtgaa ctcagtaagc cctgttgaca       60

attaatcatc ggca                                                         74


<210>  2
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
gaagacagaa caaattgtat tcttacctgg ttttcatcag caagcctaga tcagcactgt       60

cctgctcctt                                                              70


<210>  3
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
caagttcact ctttcttaac gttttctctc tctcctatcc agcatctaca ggtttctttc       60

cctcttattc acccttgtga cttcagtgaa ctcagtaagc gtttctcagt tggtaaatcc      120


<210>  4
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
caggtggggg gagggacaca gagagagagg tggggggagg gacagaggaa gaagacagaa       60

caaattgtat tcttacctgg ttttcatcag caagcctaga gaagacccgt ggcaaggaaa      120

actgg                                                                  125


<210>  5
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
ttgtttgtta aagtccattc ttccttgact atctccctgt ctctttccag cctgttgaca       60

attaatcatc ggca                                                         74


<210>  6
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
ttccccctgc agtagccata taccccgagc agtcagcccg tttcactcac tcagcactgt       60

cctgctcctt                                                              70


<210>  7
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
caggctggag gtgagtaatt ctggaagtgg agggaggggg tatggtagct ttgtttgtta       60

aagtccattc ttccttgact atctccctgt ctctttccag catctacagg tttctttccc      120

tctta                                                                  125


<210>  8
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
taaatcatgg tctgatttct aagccccgcc ctggttagat catcatcata ttccccctgc       60

agtagccata taccccgagc agtcagcccg tttcactcac agatattaga tctctcctgc      120

agaca                                                                  125


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
ggtagtgtct tctgctatgg c                                                 21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
cttgactacc tggggatgga                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
tttcccactg aggaatcgac                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
atctagggta gggcctggaa                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
ggtggtacct tccaacatgg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
gagcagctcc agttttgctt                                                   20


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
aatcgcttga acccaggag                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
ctcctgggtt caagcgatt                                                    19


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
tttgcacgct ttcctgtagc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
gggacaggat atgggatgtg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
tcctcagtcc gagaatcctg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
cttgactacc tggggatgga                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
tcctcagtcc gagaatcctg                                                   20


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
gctagacaca gtgtactcaa catgg                                             25


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
tcctcagtcc gagaatcctg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ccaagggttg gactctgtgt                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
gcctgaagaa cgagatcagc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
cttgactacc tggggatgga                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
aatcgcttga acccaggag                                                    19


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
ggacagagga agaagacaga acaa                                              24


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
tttcccactg aggaatcgac                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
atctagggta gggcctggaa                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
tttgcacgct ttcctgtagc                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
gggacaggat atgggatgtg                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
tttccaggca ctgtcacttg                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
tgtgggctct tgtaccattg                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
tcctcagtcc gagaatcctg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
ttggtcccct tactgtcgtc                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
ggcaggagca tctacaggtt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
agacgatctt ctgcccagtg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
tttgtgaggt cacagcttgc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
gtagatgaac tcgccgtcct                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
ggttgtctcc tgcgacttca                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
gggtggtcca gggtttctta                                                   20


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
gatatcacca tggtgagcaa gggc                                              24


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
gatatccacc atggtgagca agggc                                             25


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Met Val Glu Met Leu Pro Thr Val Ala Val Leu Val Leu Ala Val Ser 
1               5                   10                  15      


Val Val Ala 
            


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  46

Lys Asp Asn Thr Thr 
1               5   


<210>  47
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Cys Arg Gln Arg Gly Gly Ser Trp Ser Pro Ser Gly Trp Phe 
1               5                   10                  15      


Asn Ala Gly Trp Ser Thr Tyr Arg Ser Ile Ser Leu Phe Phe Ala Leu 
            20                  25                  30          


Val Thr Ser Gly Asn Ser Ile Asp Val Ser Gln Leu Val Asn Pro Ala 
        35                  40                  45              


Phe Pro Gly Thr Val Thr Cys Asp Glu Arg Glu Ile Thr Val Glu Phe 
    50                  55                  60                  


Pro Ser Ser Pro Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Pro 
65                  70                  75                  80  


Leu Gly Leu Asp Met Pro Asn Cys Thr Tyr Ile Leu Asp Pro Glu Lys 
                85                  90                  95      


Leu Thr Leu Arg Ala Thr Tyr Asp Asn Cys Thr Arg Arg Val His Gly 
            100                 105                 110         


Gly His Gln Met Thr Ile Arg Val Met Asn Asn Ser Ala Ala Leu Arg 
        115                 120                 125             


His Gly Ala Val Met Tyr Gln Phe Phe Cys Pro Ala Met Gln Val Glu 
    130                 135                 140                 


Glu Thr Gln Gly Leu Ser Ala Ser Thr Ile Cys Gln Lys Asp Phe Met 
145                 150                 155                 160 


Ser Phe Ser Leu Pro Arg Val Phe Ser Gly Leu Ala Asp Asp Ser Lys 
                165                 170                 175     


Gly Thr Lys Val Gln Met Gly Trp Ser Ile Glu Val Gly Asp Gly Ala 
            180                 185                 190         


Arg Ala Lys Thr Leu Thr Leu Pro Glu Ala Met Lys Glu Gly Phe Ser 
        195                 200                 205             


Leu Leu Ile Asp Asn His Arg Met Thr Phe His Val Pro Phe Asn Ala 
    210                 215                 220                 


Thr Gly Val Thr His Tyr Val Gln Gly Asn Ser His Leu Tyr Met Val 
225                 230                 235                 240 


Ser Leu Lys Leu Thr Phe Ile Ser Pro Gly Gln Lys Val Ile Phe Ser 
                245                 250                 255     


Ser Gln Ala Ile Cys Ala Pro Asp Pro Val Thr Cys Asn Ala Thr His 
            260                 265                 270         


Met Thr Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser 
        275                 280                 285             


Phe Glu Asn Gln Asn Ile Asp Val Ser Gln Leu His Asp Asn Gly Ile 
    290                 295                 300                 


Asp Leu Glu Ala Thr Asn Gly Met Lys Leu His Phe Ser Lys Thr Leu 
305                 310                 315                 320 


Leu Lys Thr Lys Leu Ser Glu Lys Cys Leu Leu His Gln Phe Tyr Leu 
                325                 330                 335     


Ala Ser Leu Lys Leu Thr Phe Leu Leu Arg Pro Glu Thr Val Ser Met 
            340                 345                 350         


Val Ile Tyr Pro Glu Cys Leu Cys Glu Ser Pro Val Ser Ile Val Thr 
        355                 360                 365             


Gly Glu Leu Cys Thr Gln Asp Gly Phe Met Asp Val Glu Val Tyr Ser 
    370                 375                 380                 


Tyr Gln Thr Gln Pro Ala Leu Asp Leu Gly Thr Leu Arg Val Gly Asn 
385                 390                 395                 400 


Ser Ser Cys Gln Pro Val Phe Glu Ala Gln Ser Gln Gly Leu Val Arg 
                405                 410                 415     


Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg Tyr Lys Phe Glu Asp 
            420                 425                 430         


Asp Lys Val Val Tyr Glu Asn Glu Ile His Ala Leu Trp Thr Asp Phe 
        435                 440                 445             


Pro Pro Ser Lys Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val Lys 
    450                 455                 460                 


Cys Ser Tyr Ser Arg Asn Asp Met Leu Leu Asn Ile Asn Val Glu Ser 
465                 470                 475                 480 


Leu Thr Pro Pro Val Ala Ser Val Lys Leu Gly Pro Phe Thr Leu Ile 
                485                 490                 495     


Leu Gln Ser Tyr Pro Asp Asn Ser Tyr Gln Gln Pro Tyr Gly Glu Asn 
            500                 505                 510         


Glu Tyr Pro Leu Val Arg Phe Leu Arg Gln Pro Ile Tyr Met Glu Val 
        515                 520                 525             


Arg Val Leu Asn Arg Asp Asp Pro Asn Ile Lys Leu Val Leu Asp Asp 
    530                 535                 540                 


Cys Trp Ala Thr Ser Thr Met Asp Pro Asp Ser Phe Pro Gln Trp Asn 
545                 550                 555                 560 


Val Val Val Asp Gly Cys Ala Tyr Asp Leu Asp Asn Tyr Gln Thr Thr 
                565                 570                 575     


Phe His Pro Val Gly Ser Ser Val Thr His Pro Asp His Tyr Gln Arg 
            580                 585                 590         


Phe Asp Met Lys Ala Phe Ala Phe Val Ser Glu Ala His Val Leu Ser 
        595                 600                 605             


Ser Leu Val Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Arg Leu Ser 
    610                 615                 620                 


Pro Asp Ser Pro Leu Cys Ser Val Thr Cys Pro Val Ser Ser Arg His 
625                 630                 635                 640 


Arg Arg Ala Thr Gly Ala Thr Glu Ala Glu Lys Met Thr Val Ser Leu 
                645                 650                 655     


Pro Gly Pro Ile Leu Leu Leu Ser Asp Asp Ser Ser Phe Arg Gly Val 
            660                 665                 670         


Gly Ser Ser Asp Leu Lys Ala Ser Gly Ser Ser Gly Glu Lys Ser Arg 
        675                 680                 685             


Ser Glu Thr Gly Glu Glu Val Gly Ser Arg Gly Ala Met Asp Thr Lys 
    690                 695                 700                 


Gly His Lys Thr Ala Gly Asp Val Gly Ser Lys Ala Val Ala Ala Val 
705                 710                 715                 720 


Ala Ala Phe Ala Gly Val Val Ala Thr Leu Gly Phe Ile Tyr Tyr Leu 
                725                 730                 735     


Tyr Glu Lys Arg Thr Val Ser Asn His 
            740                 745 


<210>  48
<211>  713
<212>  PRT
<213>  Mus musculus

<400>  48

Met Ala Arg Trp Gln Arg Lys Ala Ser Val Ser Ser Pro Cys Gly Arg 
1               5                   10                  15      


Ser Ile Tyr Arg Phe Leu Ser Leu Leu Phe Thr Leu Val Thr Ser Val 
            20                  25                  30          


Asn Ser Val Ser Leu Pro Gln Ser Glu Asn Pro Ala Phe Pro Gly Thr 
        35                  40                  45              


Leu Ile Cys Asp Lys Asp Glu Val Arg Ile Glu Phe Ser Ser Arg Phe 
    50                  55                  60                  


Asp Met Glu Lys Trp Asn Pro Ser Val Val Asp Thr Leu Gly Ser Glu 
65                  70                  75                  80  


Ile Leu Asn Cys Thr Tyr Ala Leu Asp Leu Glu Arg Phe Val Leu Lys 
                85                  90                  95      


Phe Pro Tyr Glu Thr Cys Thr Ile Lys Val Val Gly Gly Tyr Gln Val 
            100                 105                 110         


Asn Ile Arg Val Gly Asp Thr Thr Thr Asp Val Arg Tyr Lys Asp Asp 
        115                 120                 125             


Met Tyr His Phe Phe Cys Pro Ala Ile Gln Ala Glu Thr His Glu Ile 
    130                 135                 140                 


Ser Glu Ile Val Val Cys Arg Arg Asp Leu Ile Ser Phe Ser Phe Pro 
145                 150                 155                 160 


Gln Leu Phe Ser Arg Leu Ala Asp Glu Asn Gln Asn Val Ser Glu Met 
                165                 170                 175     


Gly Trp Ile Val Lys Ile Gly Asn Gly Thr Arg Ala His Ile Leu Pro 
            180                 185                 190         


Leu Lys Asp Ala Ile Val Gln Gly Phe Asn Leu Leu Ile Asp Ser Gln 
        195                 200                 205             


Lys Val Thr Leu His Val Pro Ala Asn Ala Thr Gly Ile Val His Tyr 
    210                 215                 220                 


Val Gln Glu Ser Ser Tyr Leu Tyr Thr Val Gln Leu Glu Leu Leu Phe 
225                 230                 235                 240 


Ser Thr Thr Gly Gln Lys Ile Val Phe Ser Ser His Ala Ile Cys Ala 
                245                 250                 255     


Pro Asp Leu Ser Val Ala Cys Asn Ala Thr His Met Thr Leu Thr Ile 
            260                 265                 270         


Pro Glu Phe Pro Gly Lys Leu Glu Ser Val Asp Phe Gly Gln Trp Ser 
        275                 280                 285             


Ile Pro Glu Asp Gln Trp His Ala Asn Gly Ile Asp Lys Glu Ala Thr 
    290                 295                 300                 


Asn Gly Leu Arg Leu Asn Phe Arg Lys Ser Leu Leu Lys Thr Lys Pro 
305                 310                 315                 320 


Ser Glu Lys Cys Pro Phe Tyr Gln Phe Tyr Leu Ser Ser Leu Lys Leu 
                325                 330                 335     


Thr Phe Tyr Phe Gln Gly Asn Met Leu Ser Thr Val Ile Asp Pro Glu 
            340                 345                 350         


Cys His Cys Glu Ser Pro Val Ser Ile Asp Glu Leu Cys Ala Gln Asp 
        355                 360                 365             


Gly Phe Met Asp Phe Glu Val Tyr Ser His Gln Thr Lys Pro Ala Leu 
    370                 375                 380                 


Asn Leu Asp Thr Leu Leu Val Gly Asn Ser Ser Cys Gln Pro Ile Phe 
385                 390                 395                 400 


Lys Val Gln Ser Val Gly Leu Ala Arg Phe His Ile Pro Leu Asn Gly 
                405                 410                 415     


Cys Gly Thr Arg Gln Lys Phe Glu Gly Asp Lys Val Ile Tyr Glu Asn 
            420                 425                 430         


Glu Ile His Ala Leu Trp Glu Asn Pro Pro Ser Asn Ile Val Phe Arg 
        435                 440                 445             


Asn Ser Glu Phe Arg Met Thr Val Arg Cys Tyr Tyr Ile Arg Asp Ser 
    450                 455                 460                 


Met Leu Leu Asn Ala His Val Lys Gly His Pro Ser Pro Glu Ala Phe 
465                 470                 475                 480 


Val Lys Pro Gly Pro Leu Val Leu Val Leu Gln Thr Tyr Pro Asp Gln 
                485                 490                 495     


Ser Tyr Gln Arg Pro Tyr Arg Lys Asp Glu Tyr Pro Leu Val Arg Tyr 
            500                 505                 510         


Leu Arg Gln Pro Ile Tyr Met Glu Val Lys Val Leu Ser Arg Asn Asp 
        515                 520                 525             


Pro Asn Ile Lys Leu Val Leu Asp Asp Cys Trp Ala Thr Ser Ser Glu 
    530                 535                 540                 


Asp Pro Ala Ser Ala Pro Gln Trp Gln Ile Val Met Asp Gly Cys Glu 
545                 550                 555                 560 


Tyr Glu Leu Asp Asn Tyr Arg Thr Thr Phe His Pro Ala Gly Ser Ser 
                565                 570                 575     


Ala Ala His Ser Gly His Tyr Gln Arg Phe Asp Val Lys Thr Phe Ala 
            580                 585                 590         


Phe Val Ser Glu Ala Arg Gly Leu Ser Ser Leu Ile Tyr Phe His Cys 
        595                 600                 605             


Ser Ala Leu Ile Cys Asn Gln Val Ser Leu Asp Ser Pro Leu Cys Ser 
    610                 615                 620                 


Val Thr Cys Pro Ala Ser Leu Arg Ser Lys Arg Glu Ala Asn Lys Glu 
625                 630                 635                 640 


Asp Thr Met Thr Val Ser Leu Pro Gly Pro Ile Leu Leu Leu Ser Asp 
                645                 650                 655     


Val Ser Ser Ser Lys Gly Val Asp Pro Ser Ser Ser Glu Ile Thr Lys 
            660                 665                 670         


Asp Ile Ile Ala Lys Asp Ile Ala Ser Lys Thr Leu Gly Ala Val Ala 
        675                 680                 685             


Ala Leu Val Gly Ser Ala Val Ile Leu Gly Phe Ile Cys Tyr Leu Tyr 
    690                 695                 700                 


Lys Lys Arg Thr Ile Arg Phe Asn His 
705                 710             


<210>  49
<211>  715
<212>  PRT
<213>  Canis familiaris

<400>  49

Met Ala Cys Lys Gln Lys Gly Asp Ser Gly Ser Pro Ser Ser Arg Phe 
1               5                   10                  15      


Ser Ala Asp Trp Ser Thr Tyr Arg Ser Leu Ser Leu Phe Phe Ile Leu 
            20                  25                  30          


Val Thr Ser Val Asn Ser Val Gly Val Met Gln Leu Val Asn Pro Ile 
        35                  40                  45              


Phe Pro Gly Thr Val Ile Cys His Glu Asn Lys Met Thr Val Glu Phe 
    50                  55                  60                  


Pro Arg Asp Leu Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Pro 
65                  70                  75                  80  


Phe Ser Phe Glu Leu Leu Asn Cys Thr Ser Ile Leu Asp Pro Glu Lys 
                85                  90                  95      


Leu Thr Leu Lys Ala Pro Tyr Glu Thr Cys Ser Arg Arg Val Leu Gly 
            100                 105                 110         


Gln His Gln Met Ala Ile Arg Leu Thr Asp Asn Asn Ala Ala Ser Arg 
        115                 120                 125             


His Lys Ala Phe Met Tyr Gln Ile Ser Cys Pro Val Met Gln Thr Glu 
    130                 135                 140                 


Glu Thr His Glu His Ala Gly Ser Thr Ile Cys Thr Lys Asp Ser Met 
145                 150                 155                 160 


Ser Phe Thr Phe Asn Ile Ile Pro Gly Met Ala Asp Glu Asn Thr Asn 
                165                 170                 175     


Pro Ser Gly Gly Lys Trp Met Met Glu Val Asp Asp Ala Lys Ala Gln 
            180                 185                 190         


Asn Leu Thr Leu Arg Glu Ala Leu Met Gln Gly Tyr Asn Phe Leu Phe 
        195                 200                 205             


Asp Ser His Arg Leu Ser Val Gln Val Ser Phe Asn Ala Thr Gly Val 
    210                 215                 220                 


Thr His Tyr Met Gln Gly Asn Ser His Leu Tyr Thr Val Pro Leu Lys 
225                 230                 235                 240 


Leu Ile His Thr Ser Pro Gly Gln Lys Ile Ile Leu Thr Thr Arg Val 
                245                 250                 255     


Leu Cys Met Ser Asp Pro Val Thr Cys Asn Ala Thr His Met Thr Leu 
            260                 265                 270         


Thr Ile Pro Glu Phe Pro Gly Lys Leu Gln Ser Val Arg Phe Glu Asn 
        275                 280                 285             


Thr Asn Phe Arg Val Ser Gln Leu His Asn His Gly Ile Asp Lys Glu 
    290                 295                 300                 


Glu Leu Asn Gly Leu Arg Leu His Phe Ser Lys Ser Leu Leu Lys Met 
305                 310                 315                 320 


Asn Ser Ser Glu Lys Cys Leu Leu Tyr Gln Phe Tyr Leu Ala Ser Leu 
                325                 330                 335     


Lys Leu Thr Phe Ala Phe Glu Arg Asp Thr Val Ser Thr Val Val Tyr 
            340                 345                 350         


Pro Glu Cys Val Cys Glu Pro Pro Val Thr Ile Val Thr Gly Asp Leu 
        355                 360                 365             


Cys Thr Gln Asp Gly Phe Met Asp Val Lys Val Tyr Ser His Gln Thr 
    370                 375                 380                 


Lys Pro Ala Leu Asn Leu Asp Thr Leu Arg Val Gly Asp Ser Ser Cys 
385                 390                 395                 400 


Gln Pro Thr Phe Lys Ala Pro Ser Gln Gly Leu Thr Leu Phe His Ile 
                405                 410                 415     


Pro Leu Asn Gly Cys Gly Thr Arg Leu Lys Phe Lys Gly Asp Thr Val 
            420                 425                 430         


Ile Tyr Glu Asn Glu Ile His Ala Leu Trp Thr Asp Leu Pro Pro Ser 
        435                 440                 445             


Thr Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val Lys Cys His Tyr 
    450                 455                 460                 


Ser Arg Asp Asp Leu Leu Ile Asn Thr Asn Val Gln Ser Leu Pro Pro 
465                 470                 475                 480 


Pro Val Ala Ser Val Arg Pro Gly Pro Leu Ala Leu Ile Leu Gln Thr 
                485                 490                 495     


Tyr Pro Asp Lys Ser Tyr Leu Arg Pro Tyr Gly Asp Lys Glu Tyr Pro 
            500                 505                 510         


Val Val Arg Tyr Leu Arg Gln Pro Ile Tyr Leu Glu Val Lys Val Leu 
        515                 520                 525             


Asn Arg Ala Asp Pro Asn Ile Lys Leu Val Leu Asp Asp Cys Trp Ala 
    530                 535                 540                 


Thr Pro Thr Met Asp Pro Ala Ser Leu Pro Gln Trp Asn Ile Val Met 
545                 550                 555                 560 


Asp Gly Cys Glu Tyr Asn Leu Asp Asn Tyr Arg Thr Thr Phe His Pro 
                565                 570                 575     


Val Gly Ser Ser Val Thr Tyr Pro Thr His Tyr Gln Arg Phe Asp Val 
            580                 585                 590         


Lys Thr Phe Ala Phe Ile Ser Glu Ala Gln Val Leu Ser Ser Leu Val 
        595                 600                 605             


Tyr Phe His Cys Thr Ala Leu Ile Cys Asn Arg Leu Ser Pro Asp Ser 
    610                 615                 620                 


Pro Leu Cys Ser Val Thr Cys Pro Val Ser Ser Arg His Arg Arg Ala 
625                 630                 635                 640 


Thr Gly Ser Thr Glu Glu Glu Lys Met Ile Val Ser Leu Pro Gly Pro 
                645                 650                 655     


Ile Leu Leu Leu Ala Asp Ser Ser Ser Leu Arg Asp Gly Val Asp Ser 
            660                 665                 670         


Lys Gly His Arg Ala Ala Gly Tyr Val Ala Phe Lys Thr Val Val Ala 
        675                 680                 685             


Val Ala Ala Leu Ala Gly Leu Val Ala Ala Leu Gly Leu Ile Ile Tyr 
    690                 695                 700                 


Leu Arg Lys Lys Arg Thr Met Val Leu Asn His 
705                 710                 715 


<210>  50
<211>  716
<212>  PRT
<213>  Felis catus

<400>  50

Met Ala Ser Arg Gln Lys Gly Asp Ser Gly Ser Pro Ser Ser Trp Phe 
1               5                   10                  15      


Asn Ala Asp Trp Ser Thr Tyr Arg Ser Leu Phe Leu Leu Phe Ile Leu 
            20                  25                  30          


Val Thr Ser Val Asn Ser Ile Gly Val Leu Gln Leu Val Asn Pro Val 
        35                  40                  45              


Phe Pro Gly Thr Val Thr Cys Tyr Glu Thr Arg Met Ala Val Glu Phe 
    50                  55                  60                  


Pro Ser Asp Phe Gly Thr Lys Lys Trp His Thr Ser Val Val Asp Pro 
65                  70                  75                  80  


Phe Ser Phe Glu Leu Leu Asn Cys Thr Tyr Ile Leu Asp Pro Glu Asn 
                85                  90                  95      


Leu Thr Leu Lys Ala Pro Tyr Glu Thr Cys Thr Arg Arg Thr Leu Gly 
            100                 105                 110         


Gln His Arg Met Ile Ile Arg Leu Lys Asp His Asn Ala Ala Ser Arg 
        115                 120                 125             


His Asn Ser Leu Met Tyr Gln Ile Asn Cys Pro Val Met Gln Ala Glu 
    130                 135                 140                 


Glu Thr His Glu His Ala Gly Ser Thr Ile Cys Thr Lys Asp Ser Met 
145                 150                 155                 160 


Ser Phe Thr Phe Asn Val Ile Pro Gly Leu Ala Asp Glu Asn Thr Asp 
                165                 170                 175     


Ile Lys Asn Pro Met Gly Trp Ser Ile Glu Val Gly Asp Gly Thr Lys 
            180                 185                 190         


Ala Lys Thr Leu Thr Leu Gln Asp Val Leu Arg Gln Gly Tyr Asn Ile 
        195                 200                 205             


Leu Phe Asp Asn His Lys Ile Thr Phe Gln Val Ser Phe Asn Ala Thr 
    210                 215                 220                 


Gly Val Thr His Tyr Met Gln Gly Asn Ser His Leu Tyr Met Val Pro 
225                 230                 235                 240 


Leu Lys Leu Ile His Glu Ser Leu Gly Gln Lys Ile Ile Leu Thr Thr 
                245                 250                 255     


Arg Val Leu Cys Met Ser Asp Ala Val Thr Cys Asn Ala Thr His Val 
            260                 265                 270         


Thr Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser Ser 
        275                 280                 285             


Glu Asn Arg Asn Phe Ala Val Ser Gln Leu His Asn Asn Gly Ile Asp 
    290                 295                 300                 


Lys Glu Glu Ser Ser Gly Leu Thr Leu His Phe Ser Lys Thr Leu Leu 
305                 310                 315                 320 


Lys Met Glu Phe Ser Glu Lys Cys Leu Pro Tyr Gln Phe Tyr Leu Ala 
                325                 330                 335     


Ser Leu Lys Leu Thr Phe Ala Phe Asn Gln Glu Thr Ile Ser Thr Val 
            340                 345                 350         


Leu Tyr Pro Glu Cys Val Cys Glu Ser Pro Val Ser Ile Val Thr Gly 
        355                 360                 365             


Asp Leu Cys Thr Gln Asp Gly Phe Met Asp Ile Lys Val Tyr Ser His 
    370                 375                 380                 


Gln Thr Lys Pro Ala Leu Asn Leu Glu Thr Leu Arg Gly Gly Asp Ser 
385                 390                 395                 400 


Ser Cys Gln Pro Thr Phe Gln Ala Ala Ser Gln Gly Leu Ile Leu Phe 
                405                 410                 415     


His Ile Pro Leu Asn Gly Cys Gly Thr Arg His Lys Phe Lys Glu Gly 
            420                 425                 430         


Lys Val Ile Tyr Glu Asn Glu Ile His Ala Val Trp Ala Asp Leu Pro 
        435                 440                 445             


Pro Ser Thr Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val Gln Cys 
    450                 455                 460                 


His Tyr Ser Lys Gly Asp Leu Leu Ile Asn Thr Arg Val Gln Ser Leu 
465                 470                 475                 480 


Pro Pro Pro Glu Ala Ser Val Arg Pro Gly Pro Leu Ala Leu Ile Leu 
                485                 490                 495     


Gln Thr Tyr Pro Asp Lys Ser Tyr Leu Gln Pro Tyr Gly Glu Lys Glu 
            500                 505                 510         


Tyr Pro Val Val Arg Tyr Leu Arg Gln Pro Ile Tyr Leu Glu Val Arg 
        515                 520                 525             


Val Leu Asn Arg Ser Asp Pro Asn Ile Lys Leu Val Leu Asp Asp Cys 
    530                 535                 540                 


Trp Ala Thr Pro Thr Met Asp Pro Ala Ser Val Pro Gln Trp Asn Ile 
545                 550                 555                 560 


Ile Met Asp Gly Cys Glu Tyr Asn Leu Asp Asn His Arg Thr Thr Phe 
                565                 570                 575     


His Pro Val Gly Ser Ser Val Thr Tyr Pro Thr His Tyr Arg Arg Phe 
            580                 585                 590         


Asp Val Lys Thr Phe Ala Phe Val Ser Glu Ala Gln Val Leu Ser Ser 
        595                 600                 605             


Leu Val Tyr Phe His Cys Ser Val Leu Ile Cys Ser Arg Leu Ser Ala 
    610                 615                 620                 


Asp Ser Pro Leu Cys Ser Val Thr Cys Pro Val Ser Ser Arg His Arg 
625                 630                 635                 640 


Arg Ala Thr Gly Thr Thr Glu Glu Glu Lys Met Ile Val Ser Leu Pro 
                645                 650                 655     


Gly Pro Ile Leu Leu Leu Ser Asp Ser Ser Ser Leu Arg Asp Val Val 
            660                 665                 670         


Asp Ser Lys Gly Tyr Gly Ala Ala Gly Tyr Val Ala Phe Lys Thr Val 
        675                 680                 685             


Val Ala Val Ala Ala Leu Ala Gly Leu Val Ala Thr Leu Gly Phe Ile 
    690                 695                 700                 


Thr Tyr Leu Arg Lys Asn Arg Thr Met Ile Asn His 
705                 710                 715     


<210>  51
<211>  695
<212>  PRT
<213>  Rattus norvegicus

<400>  51

Met Ala Arg Trp Gln Arg Val Tyr Trp Leu Arg Ser Leu Phe Phe Ala 
1               5                   10                  15      


Leu Val Thr Ser Val Asn Ser Leu Ser Leu Pro Gln Ser Glu Asn Pro 
            20                  25                  30          


Ala Phe Pro Gly Thr Leu Ile Cys Asp Lys Asp Glu Val Arg Val Glu 
        35                  40                  45              


Phe Ser Ser Arg Phe Asp Met Glu Lys Trp Asn Pro Ser Leu Val Asp 
    50                  55                  60                  


Thr Phe Gly Asn Glu Ile Ser Asn Cys Thr Tyr Ala Leu Asp Leu Glu 
65                  70                  75                  80  


Lys Phe Ile Leu Lys Phe Pro Tyr Glu Thr Cys Thr Ile Lys Val Ile 
                85                  90                  95      


Gly Gly Tyr Gln Val Asn Ile Arg Val Gln Asp Thr Asn Ala Asp Val 
            100                 105                 110         


Ser Tyr Lys Asp Asp Val His His Phe Phe Cys Pro Ala Ile Gln Ala 
        115                 120                 125             


Glu Ile His Glu Val Ser Glu Ile Val Val Cys Met Glu Asp Leu Ile 
    130                 135                 140                 


Ser Phe Ser Phe Pro Gln Leu Phe Ser Arg Leu Ala Asp Glu Asn Gln 
145                 150                 155                 160 


Asn Val Ser Glu Met Gly Trp Ile Ile Lys Ile Gly Asn Gly Thr Arg 
                165                 170                 175     


Val His Thr Leu Pro Leu Lys Asp Ala Ile Val Gln Gly Phe Asn Leu 
            180                 185                 190         


Leu Ile Asp Ser Gln Lys Ile Thr Leu His Val Pro Ala Asn Ala Thr 
        195                 200                 205             


Gly Val Ala His Tyr Val Gln Glu Ser Ser Tyr Leu Tyr Thr Val Gln 
    210                 215                 220                 


Leu Lys Leu Leu Phe Ser Ser Pro Gly Gln Lys Ile Thr Phe Ser Ser 
225                 230                 235                 240 


Gln Ala Ile Cys Ala Pro Asp Leu Ser Val Ala Cys Asn Val Thr His 
                245                 250                 255     


Met Ser Leu Thr Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Gly 
            260                 265                 270         


Phe Gly Gln Arg Asn Ile Pro Glu Asp Gln Trp His Ala Asn Gly Ile 
        275                 280                 285             


Asp Lys Glu Ala Thr Asn Gly Leu Arg Leu His Phe Arg Lys Ser Leu 
    290                 295                 300                 


Leu Lys Thr Lys Pro Ser Glu Lys Cys Pro Phe Tyr Gln Phe Tyr Phe 
305                 310                 315                 320 


Ser Ser Leu Glu Leu Thr Phe Asn Phe Gln Gly Asp Met Leu Ser Thr 
                325                 330                 335     


Val Ile Asp Pro Glu Cys His Cys Glu Ser Pro Val Ser Ile Asp Glu 
            340                 345                 350         


Leu Cys Thr Arg Asp Gly Phe Met Asp Phe Glu Val Tyr Ser His Gln 
        355                 360                 365             


Thr Lys Pro Ala Leu Asn Leu Glu Ser Leu Leu Val Gly Asn Ser Ser 
    370                 375                 380                 


Cys Gln Pro Ile Phe Lys Val Gln Ser Leu Gly Leu Ala Arg Phe His 
385                 390                 395                 400 


Ile Pro Leu Asn Gly Cys Gly Thr Arg Gln Lys Phe Glu Gly Asp Lys 
                405                 410                 415     


Val Ile Tyr Glu Asn Glu Ile His Ala Leu Trp Glu Asn Pro Pro Ser 
            420                 425                 430         


Asn Ile Ile Phe Arg Asn Ser Glu Phe Arg Met Thr Val Arg Cys His 
        435                 440                 445             


Tyr Ile Arg Asp Ser Met Leu Leu Arg Ala His Ile Lys Ser His Ser 
    450                 455                 460                 


Ser Pro Val Ala Ser Val Lys Pro Gly Pro Leu Ala Leu Val Leu Gln 
465                 470                 475                 480 


Thr Tyr Pro Asp Ile Ser Tyr Gln Arg Pro Tyr Arg Lys Asn Glu Tyr 
                485                 490                 495     


Pro Leu Val Arg Tyr Leu Arg Gln Pro Ile Tyr Met Glu Val Thr Val 
            500                 505                 510         


Leu Asn Arg Asn Asp Pro Asn Ile Lys Leu Val Leu Asp Asp Cys Trp 
        515                 520                 525             


Ala Thr Thr Phe Glu Asp Pro Ala Ser Val Pro Gln Trp Gln Ile Ile 
    530                 535                 540                 


Met Asp Gly Cys Glu Tyr Glu Leu Asp Asn Tyr Arg Thr Thr Phe His 
545                 550                 555                 560 


Ala Ala Asn Ser Ser Ala Ala His Ser Gly His Tyr Gln Arg Phe Asp 
                565                 570                 575     


Val Lys Thr Phe Ala Phe Val Ser Glu Ser Arg Gly Leu Ser Ser Leu 
            580                 585                 590         


Ile Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Gln Ala Ser Pro Leu 
        595                 600                 605             


Cys Ser Val Thr Cys Pro Ala Pro Leu Arg Asn Lys Arg Glu Ala Ser 
    610                 615                 620                 


Lys Glu Gly Thr Met Thr Val Ser Leu Pro Gly Pro Ile Ile Leu Leu 
625                 630                 635                 640 


Ser Asp Asp Ser Ser Ser Lys Gly Val Met Asn Pro Asp Ser Tyr Glu 
                645                 650                 655     


Ile Thr Lys Asp Ile Ala Ser Lys Thr Leu Gly Ala Val Ala Ala Leu 
            660                 665                 670         


Val Gly Ser Ala Val Ile Ile Gly Phe Ile Cys Tyr Leu His Lys Lys 
        675                 680                 685             


Arg Ile Val Arg Phe Asn Ser 
    690                 695 


<210>  52
<211>  713
<212>  PRT
<213>  Bos taurus

<400>  52

Met Ala Cys Arg Gln Arg Gly Asp Ser Gly Arg Pro Ser Ser Trp Phe 
1               5                   10                  15      


Arg Ala Asp Trp Arg Ser Phe Phe Leu Ser Phe Thr Leu Leu Thr Ser 
            20                  25                  30          


Val Asn Ser Ile Asp Val Asn Gln Leu Asp Pro Ala Phe Pro Gly Thr 
        35                  40                  45              


Val Thr Cys Tyr Glu Asn Arg Met Val Val Glu Phe Lys Arg Thr Leu 
    50                  55                  60                  


Gly Asn Lys Ile Gln His Ala Ser Val Val Asp Ser Leu Gly Leu Lys 
65                  70                  75                  80  


Met Leu Asn Cys Thr Tyr Val Leu Asp Pro Glu Lys Leu Thr Leu Lys 
                85                  90                  95      


Ala Pro Tyr Glu Ser Cys Thr Lys Arg Val Leu Gly Gln His Gln Met 
            100                 105                 110         


Thr Ile Thr Phe Met Asn Asp Asn Thr Ala His Arg Gln Lys Thr Val 
        115                 120                 125             


Leu Tyr His Val Ser Cys Pro Val Met Gln Ala Gly Arg His Asp Gln 
    130                 135                 140                 


His Ser Gly Ser Thr Ile Cys Ser Lys Asp Phe Met Ser Phe Thr Phe 
145                 150                 155                 160 


His Phe Phe Pro Gly Leu Ala Asp Asp Thr Ala Gly Pro Lys Pro Gln 
                165                 170                 175     


Met Gly Trp Thr Val Thr Val Gly Asp Gly Glu Arg Ala Gln Asn Leu 
            180                 185                 190         


Thr Leu Gln Glu Ala Leu Thr Gln Gly Tyr Asn Leu Leu Ile Glu Asn 
        195                 200                 205             


Gln Lys Met Ser Ile Gln Val Leu Phe His Ala Thr Gly Val Thr His 
    210                 215                 220                 


Tyr Ser Gln Gly Asn Ser His Leu Tyr Met Val Pro Leu Lys Leu Thr 
225                 230                 235                 240 


His Val Ser Pro Gly Gln Thr Ile Ile Leu Ser Ser Arg Leu Ile Cys 
                245                 250                 255     


Ala Ser Asp Pro Val Thr Cys Asn Ala Thr His Met Thr Leu Thr Ile 
            260                 265                 270         


Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Ser Phe Glu Asn Lys Asn 
        275                 280                 285             


Ile Ala Val Asn Gln Leu His Asn Ser Gly Ile Val Met Glu Ile Ala 
    290                 295                 300                 


Asn Gly Leu Arg Leu His Phe Ser Lys Thr Leu Leu Lys Thr Lys Phe 
305                 310                 315                 320 


Ser Glu Lys Cys Leu Pro Tyr Gln Phe Tyr Leu Ser Ser Leu Lys Leu 
                325                 330                 335     


Thr Phe Tyr Thr Gln Leu Glu Thr Val Ser Met Val Ile Tyr Pro Glu 
            340                 345                 350         


Cys Val Cys Glu Ser Thr Val Ser Ile Val Ser Gly Glu Leu Cys Thr 
        355                 360                 365             


Gln Asp Gly Phe Met Asp Val Glu Val Tyr Arg His Gln Thr Lys Pro 
    370                 375                 380                 


Ala Leu Asn Leu Asp Thr Leu Arg Val Gly Asp Ser Ser Cys Gln Pro 
385                 390                 395                 400 


Thr Ile Lys Ala Pro Phe Gln Gly Leu Val Lys Phe His Ile Pro Leu 
                405                 410                 415     


Asn Gly Cys Gly Thr Arg His Lys Phe Glu Asn Gly Lys Val Ile Tyr 
            420                 425                 430         


Glu Asn Glu Ile His Ala Leu Trp Ala Asp Leu Pro Pro Ser Thr Ile 
        435                 440                 445             


Ser Arg Asp Ser Glu Phe Arg Met Thr Val Arg Cys Tyr Tyr Ser Ser 
    450                 455                 460                 


Ser Asn Met Leu Ile Asn Thr Asn Val Glu Ser Leu Pro Pro Pro Val 
465                 470                 475                 480 


Ala Ser Val Lys Pro Gly Pro Leu Ala Leu Thr Leu Gln Thr Tyr Pro 
                485                 490                 495     


Asp Asn Ser Tyr Leu Gln Pro Tyr Gly Asp Lys Asp Tyr Pro Val Val 
            500                 505                 510         


Arg Tyr Leu Arg Gln Pro Ile Tyr Leu Glu Val Arg Val Leu Asn Arg 
        515                 520                 525             


Thr Asp Pro Asn Ile Lys Leu Val Leu Asp Asp Cys Trp Ala Thr Ser 
    530                 535                 540                 


Thr Met Asp Pro Ala Ser Leu Pro Gln Trp Asn Ile Ile Val Asp Gly 
545                 550                 555                 560 


Cys Glu Tyr Asn Leu Asp Asn His Arg Thr Thr Phe His Pro Val Gly 
                565                 570                 575     


Ser Ser Val Ala Tyr Pro Asn His Tyr Gln Arg Phe Ala Val Lys Thr 
            580                 585                 590         


Phe Ala Phe Val Ser Glu Asp Pro Ala Phe Ser His Leu Val Tyr Phe 
        595                 600                 605             


His Cys Ser Ala Leu Ile Cys Asp Gln Leu Ser Ser Asn Phe Pro Leu 
    610                 615                 620                 


Cys Ser Ala Ser Cys Leu Val Ser Ser Arg Ser Arg Arg Ala Thr Gly 
625                 630                 635                 640 


Ala Thr Glu Glu Glu Lys Met Ile Val Ser Leu Pro Gly Pro Ile Leu 
                645                 650                 655     


Leu Leu Ser Asp Gly Ser Ser Phe Arg Asp Ala Val Asp Ser Lys Gly 
            660                 665                 670         


His Gly Thr Ser Gly Tyr Ala Ala Phe Lys Thr Met Val Ala Val Val 
        675                 680                 685             


Ala Leu Ala Gly Val Val Ala Thr Leu Ser Leu Ile Ser Tyr Leu Arg 
    690                 695                 700                 


Lys Lys Arg Ile Thr Val Leu Asn His 
705                 710             


<210>  53
<211>  716
<212>  PRT
<213>  Sus scrofa

<400>  53

Met Ala Cys Arg His Arg Gly Asp Ser Gly Arg Pro Leu Ser Trp Leu 
1               5                   10                  15      


Ser Ala Ser Trp Arg Ser Leu Leu Leu Phe Phe Pro Leu Val Thr Ser 
            20                  25                  30          


Val Asn Ser Ile Gly Val Asn Gln Leu Val Asn Thr Ala Phe Pro Gly 
        35                  40                  45              


Ile Val Thr Cys His Glu Asn Arg Met Val Val Glu Phe Pro Arg Ile 
    50                  55                  60                  


Leu Gly Thr Lys Ile Gln Tyr Thr Ser Val Val Asp Pro Leu Gly Leu 
65                  70                  75                  80  


Glu Met Met Asn Cys Thr Tyr Val Leu Asp Pro Glu Asn Leu Thr Leu 
                85                  90                  95      


Lys Ala Pro Tyr Glu Ala Cys Thr Lys Arg Val Arg Gly His His Gln 
            100                 105                 110         


Met Thr Ile Arg Leu Ile Asp Asp Asn Ala Ala Leu Arg Gln Glu Ala 
        115                 120                 125             


Leu Met Tyr His Ile Ser Cys Pro Val Met Gly Ala Glu Gly Pro Asp 
    130                 135                 140                 


Gln His Ser Gly Ser Thr Ile Cys Met Lys Asp Phe Met Ser Phe Thr 
145                 150                 155                 160 


Phe Asn Phe Phe Pro Gly Met Ala Asp Glu Asn Val Lys Arg Glu Asp 
                165                 170                 175     


Ser Lys Gln Arg Met Gly Trp Ser Leu Val Val Gly Asp Gly Glu Arg 
            180                 185                 190         


Ala Arg Thr Leu Thr Phe Gln Glu Ala Met Thr Gln Gly Tyr Asn Phe 
        195                 200                 205             


Leu Ile Glu Asn Gln Lys Met Asn Ile Gln Val Ser Phe His Ala Thr 
    210                 215                 220                 


Gly Val Thr Arg Tyr Ser Gln Gly Asn Ser His Leu Tyr Met Val Pro 
225                 230                 235                 240 


Leu Lys Leu Lys His Val Ser His Gly Gln Ser Leu Ile Leu Ala Ser 
                245                 250                 255     


Gln Leu Ile Cys Val Ala Asp Pro Val Thr Cys Asn Ala Thr His Val 
            260                 265                 270         


Thr Leu Ala Ile Pro Glu Phe Pro Gly Lys Leu Lys Ser Val Asn Leu 
        275                 280                 285             


Gly Ser Gly Asn Ile Ala Val Ser Gln Leu His Lys His Gly Ile Glu 
    290                 295                 300                 


Met Glu Thr Thr Asn Gly Leu Arg Leu His Phe Asn Gln Thr Leu Leu 
305                 310                 315                 320 


Lys Thr Asn Val Ser Glu Lys Cys Gln Pro His Gln Leu Tyr Leu Ser 
                325                 330                 335     


Ser Leu Arg Leu Thr Phe His Ser Gln Leu Glu Ala Val Ser Met Val 
            340                 345                 350         


Ile Tyr Pro Glu Cys Leu Cys Glu Ser Thr Val Ser Leu Val Ser Glu 
        355                 360                 365             


Glu Leu Cys Thr Gln Asp Gly Phe Met Asp Val Lys Val His Ser His 
    370                 375                 380                 


Gln Thr Lys Pro Ala Leu Asn Leu Asp Thr Leu Arg Val Gly Asp Ser 
385                 390                 395                 400 


Ser Cys Gln Pro Thr Phe Lys Ala Pro Ala Gln Gly Leu Val Gln Phe 
                405                 410                 415     


Arg Ile Pro Leu Asn Gly Cys Gly Thr Arg His Lys Phe Lys Asn Asp 
            420                 425                 430         


Lys Val Ile Tyr Glu Asn Glu Ile His Ala Leu Trp Ala Asp Pro Pro 
        435                 440                 445             


Ser Ala Val Ser Arg Asp Ser Glu Phe Arg Met Thr Val Arg Cys Ser 
    450                 455                 460                 


Tyr Ser Ser Ser Asn Met Leu Ile Asn Thr Asn Val Glu Ser Leu Pro 
465                 470                 475                 480 


Ser Pro Glu Ala Ser Val Lys Pro Gly Pro Leu Thr Leu Thr Leu Gln 
                485                 490                 495     


Thr Tyr Pro Asp Asn Ala Tyr Leu Gln Pro Tyr Gly Asp Lys Glu Tyr 
            500                 505                 510         


Pro Val Val Lys Tyr Leu Arg Gln Pro Ile Tyr Leu Glu Val Arg Ile 
        515                 520                 525             


Leu Asn Arg Thr Asp Pro Asn Ile Lys Leu Val Leu Asp Asp Cys Trp 
    530                 535                 540                 


Ala Thr Ser Thr Glu Asp Pro Ala Ser Leu Pro Gln Trp Asn Val Val 
545                 550                 555                 560 


Met Asp Gly Cys Glu Tyr Asn Leu Asp Asn His Arg Thr Thr Phe His 
                565                 570                 575     


Pro Val Gly Ser Ser Val Thr Tyr Pro Asn His His Gln Arg Phe Asp 
            580                 585                 590         


Val Lys Thr Phe Ala Phe Val Ser Gly Ala Gln Gly Val Ser Gln Leu 
        595                 600                 605             


Val Tyr Phe His Cys Ser Val Phe Ile Cys Asn Gln Leu Ser Pro Thr 
    610                 615                 620                 


Phe Ser Leu Cys Ser Val Thr Cys His Gly Pro Ser Arg Ser Arg Arg 
625                 630                 635                 640 


Ala Thr Gly Thr Thr Glu Glu Glu Lys Met Ile Val Ser Leu Pro Gly 
                645                 650                 655     


Pro Ile Leu Leu Leu Ser Asp Gly Ser Ser Leu Arg Asp Ala Val Asn 
            660                 665                 670         


Ser Lys Gly Ser Arg Thr Asn Gly Tyr Val Ala Phe Lys Thr Met Val 
        675                 680                 685             


Ala Met Val Ala Ser Ala Gly Ile Val Ala Thr Leu Gly Leu Ile Ser 
    690                 695                 700                 


Tyr Leu His Lys Lys Arg Ile Met Met Leu Asn His 
705                 710                 715     


<210>  54
<211>  723
<212>  PRT
<213>  Equus caballus

<400>  54

Met Pro Leu Ala Met Ala His Arg Gln Arg Gly Asp Cys Gly Ser Pro 
1               5                   10                  15      


Ser Ser Trp Arg Asp Ser Ser Thr Asp Trp Ser Val Tyr Arg Ser Leu 
            20                  25                  30          


Ser Leu Phe Phe Ala Leu Val Thr Leu Val Asn Ser Gly Gly Ala Val 
        35                  40                  45              


Lys Leu Val Asn Pro Asp Phe Ser Gly Thr Val Thr Cys Tyr Lys Asp 
    50                  55                  60                  


Arg Met Ile Val Glu Leu Pro Ser His Leu Gly Pro Lys Lys Trp His 
65                  70                  75                  80  


Ala Ser Val Val Asp Pro Ser Gly Leu Glu Met Leu Asn Cys Thr His 
                85                  90                  95      


Asp Leu Asp Pro Glu Lys Leu Thr Leu Lys Ala Pro Tyr Glu Thr Cys 
            100                 105                 110         


Thr Arg Arg Val Leu Gly Arg His Gln Met Thr Ile Arg Leu Val Asp 
        115                 120                 125             


Asn Ser Ala Ala Leu Lys Arg Glu Glu Val Val Tyr Gln Ile Ser Cys 
    130                 135                 140                 


Pro Val Met Gln Ala Glu Glu Thr His Glu His Ser Gly Ser Thr Ile 
145                 150                 155                 160 


Cys Leu Lys Asp Phe Met Ser Phe Thr Phe Gln Ile Phe Pro Gly Met 
                165                 170                 175     


Ala Asp Glu Ser Ser Asp Pro Asp Ser Gln Met Gly Trp Ile Ile Glu 
            180                 185                 190         


Val Gly Asp Gly Thr Arg Ala Gln Thr Leu Thr Leu Trp Glu Ala Met 
        195                 200                 205             


Thr Gln Gly Tyr Asn Leu Leu Ile Asp Asn Lys Lys Ile Ile Ile Gln 
    210                 215                 220                 


Val Leu Phe Asn Ala Thr Gly Val Thr His Tyr Thr Gln Gly Asn Ser 
225                 230                 235                 240 


His Leu Tyr Met Val Pro Leu Lys Leu Thr Tyr Val Ser Pro Gly Gln 
                245                 250                 255     


Lys Val Ile Leu Ser Ser Gln Val Ile Cys Met Ser Gly Pro Val Thr 
            260                 265                 270         


Cys Asn Ala Thr His Met Thr Leu Asp Ile Pro Glu Phe Pro Gly Lys 
        275                 280                 285             


Leu Lys Ser Val Ser Phe Glu Asn Arg Lys Ile Ala Ala Ser Gln Leu 
    290                 295                 300                 


His Asn Asn Glu Ile Asp Met Glu Ala Thr Asn Gly Leu Arg Leu His 
305                 310                 315                 320 


Phe Ser Lys Thr Leu Leu Lys Ala Lys Phe Ser Glu Lys Cys Leu Pro 
                325                 330                 335     


Tyr Gln Phe Tyr Leu Pro Ser Leu Lys Leu Thr Phe Tyr Val Gln Leu 
            340                 345                 350         


Glu Thr Val Ser Met Val Val Tyr Pro Glu Cys Leu Cys Glu Ser Ser 
        355                 360                 365             


Val Ser Ile Val Thr Gly Glu Leu Cys Thr Gln Asp Gly Phe Met Asp 
    370                 375                 380                 


Ile Glu Val Tyr Ser His Gln Thr Asn Pro Ala Leu Asn Leu Asp Thr 
385                 390                 395                 400 


Leu Met Val Gly Asp Ser Ser Cys Gln Pro Thr Phe Lys Ala Pro Ser 
                405                 410                 415     


Gln Gly Leu Val Arg Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg 
            420                 425                 430         


His Lys Phe Glu Asn Asp Thr Phe Ile Tyr Glu Asn Glu Ile His Ala 
        435                 440                 445             


Leu Trp Ala Asp Leu Pro Pro Ser Thr Ile Ser Arg Asp Ser Glu Phe 
    450                 455                 460                 


Arg Met Thr Val Lys Cys His Tyr Ser Arg Asp Asp Met Leu Ile Asn 
465                 470                 475                 480 


Thr Asn Ile Glu Ser Leu Pro Pro Pro Val Ala Ser Val Lys Pro Gly 
                485                 490                 495     


Gln Leu Ala Leu Ile Leu Gln Thr Tyr Pro Asp Asn Ser Tyr Leu Gln 
            500                 505                 510         


Pro Tyr Gly Asp Lys Glu Tyr Pro Val Met Arg Tyr Leu Arg Gln Pro 
        515                 520                 525             


Ile Tyr Leu Glu Val Arg Ile Leu Asn Arg Thr Asp Pro Asn Ile Lys 
    530                 535                 540                 


Leu Val Leu Asp Asp Cys Trp Ala Thr Pro Thr Met Asp Pro Ala Ser 
545                 550                 555                 560 


Leu Pro Gln Trp Asn Ile Val Val Asp Gly Cys Glu Tyr Asn Leu Asp 
                565                 570                 575     


Asn Tyr Arg Thr Thr Phe His Pro Val Glu Ser Ser Val Thr Tyr Pro 
            580                 585                 590         


Asn His Tyr Gln Arg Phe Asp Val Lys Thr Phe Ala Phe Leu Ser Glu 
        595                 600                 605             


Ala Gln Glu Leu Ser Ser Leu Val Tyr Phe His Cys Arg Ala Leu Ile 
    610                 615                 620                 


Cys Asn Ile Leu Ser Pro Asp Ser Pro Leu Cys Ser Ala Thr Cys Pro 
625                 630                 635                 640 


Leu Ser Ser Arg Ser Arg Arg Asp Ala Gly Thr Thr Glu Gln Glu Arg 
                645                 650                 655     


Thr Leu Val Ser Leu Pro Gly Pro Ile Leu Leu Leu Ser Asp Asp Ser 
            660                 665                 670         


Ser Phe Arg Gly Val Val Asp Thr Lys Gly His Glu Thr Ala Gly Tyr 
        675                 680                 685             


Ile Ala Phe Lys Thr Ile Val Ala Val Val Ala Leu Gly Gly Val Val 
    690                 695                 700                 


Ala Thr Leu Gly Phe Ile Ser Tyr Leu His Lys Lys Arg Thr Met Met 
705                 710                 715                 720 


Leu Asn His 
            


<210>  55
<211>  702
<212>  PRT
<213>  Loxodonta africana

<400>  55

Met Ala Cys Arg Trp Arg Thr Asp Ser Arg Cys His Pro Ser Trp Phe 
1               5                   10                  15      


His Gly Val Ser Arg Ala Tyr Met Ser Leu Ser Leu Phe Phe Ala Leu 
            20                  25                  30          


Met Thr Ser Val Asn Ser Ala Gly Ala Pro Leu Leu Ala Asn Leu Ala 
        35                  40                  45              


Phe Pro Gly Thr Val Ser Cys Asn Glu Asp Gly Met Ile Val Glu Phe 
    50                  55                  60                  


Pro Lys Asp Leu Gly Thr Lys Lys Trp His Ala Ser Val Val Asp Ser 
65                  70                  75                  80  


Leu Gly Leu Glu Ile Pro Asn Cys Thr Tyr Val Leu Asp Pro Glu Lys 
                85                  90                  95      


Leu Ile Leu Arg Ala Ser Tyr Asp Asn Cys Thr Arg Arg Val His Gly 
            100                 105                 110         


Ala Tyr Gln Thr Thr Ile Arg Leu Met Asp Asn Asn Ala Ala Lys Thr 
        115                 120                 125             


Asn Glu Ala Thr Met Tyr Gln Ile Ser Cys Pro Ala Met Glu Ala Glu 
    130                 135                 140                 


Asp His Leu Ser Lys Ser Leu Val Gly Ser Thr Asp Cys Met Lys Asp 
145                 150                 155                 160 


Ser Met Ser Val Gln Thr Pro Leu Leu Gly Trp Ile Leu Lys Ile Gly 
                165                 170                 175     


Asp Gly Pro Thr Arg Ser Leu Thr Leu Ala Glu Ala Ile Lys Gln Gly 
            180                 185                 190         


Tyr Thr Val Leu Met Asp Ser Gly Lys Ile Ile Leu Gln Val Ser Phe 
        195                 200                 205             


Asn Ala Thr Gly Val Thr His Tyr Glu Gln Asp Asn Ser His Leu Tyr 
    210                 215                 220                 


Met Val Pro Leu Thr Leu Ile Tyr Glu Ser Pro Gly Gln Thr Ile Thr 
225                 230                 235                 240 


Leu Ser Thr Arg Met Ile Cys Val Thr Asp Ser Val Thr Cys Asn Ala 
                245                 250                 255     


Thr His Met Thr Leu Thr Ile Pro Gly Phe Pro Gly Lys Leu Lys Ala 
            260                 265                 270         


Val Ser Thr Glu Asn Arg Asn Ile Asn Val Ser Gln Leu His Asp Asn 
        275                 280                 285             


Gly Ile Glu Arg Glu Ala Thr Asn Gly Leu Arg Leu His Phe Ser Thr 
    290                 295                 300                 


Ser Phe Leu Lys Thr Lys Ile Ser Ala Lys Cys Leu Ser Gln Gln Phe 
305                 310                 315                 320 


Tyr Leu Pro Ser Leu Lys Leu Thr Phe His Phe His Leu Glu Thr Val 
                325                 330                 335     


Ser Met Val Val Tyr Pro Glu Cys Leu Cys Glu Ser Pro Val Ser Val 
            340                 345                 350         


Val Thr Asp Glu Leu Cys Thr Gln Asp Gly Phe Met Glu Phe Glu Val 
        355                 360                 365             


Tyr Ser His Gln Thr Lys Pro Ala Leu Asp Leu Asp Thr Leu Arg Val 
    370                 375                 380                 


Gly Asp Ser Ser Cys Gln Pro Ile Phe Lys Ala Gln Ser Gln Gly Leu 
385                 390                 395                 400 


Val Arg Phe His Ile Pro Leu Asn Gly Cys Gly Thr Arg Tyr Glu Phe 
                405                 410                 415     


Lys Glu Asp Arg Val Ile Tyr Glu Asn Glu Ile Tyr Ala Leu Trp Ala 
            420                 425                 430         


Asp Leu Pro Ser Lys Ile Ser Arg Asp Ser Glu Phe Arg Met Thr Val 
        435                 440                 445             


Lys Cys Tyr Tyr Ser Ser Ser Asp Val Leu Ile Asn Thr Asn Val Glu 
    450                 455                 460                 


Ser Leu Pro Pro Pro Val Ala Ser Val Lys Pro Gly Pro Leu Ala Leu 
465                 470                 475                 480 


Ile Leu Gln Thr Tyr Pro Asp Asn Ser Tyr Gln His Pro His Gly Asp 
                485                 490                 495     


His Glu Tyr Pro Leu Val Arg Tyr Leu Arg Gln Pro Ile Tyr Leu Glu 
            500                 505                 510         


Val Arg Ile Leu Asn Arg Thr Asp Pro Asn Ile Lys Leu Val Ile Asp 
        515                 520                 525             


Asp Cys Trp Ala Thr Ala Thr Met Asp Pro Ala Ser Leu Pro Gln Trp 
    530                 535                 540                 


Asn Ile Val Val Asp Gly Cys Glu Tyr Asn Leu Asp Asn Tyr Gln Thr 
545                 550                 555                 560 


Thr Phe His Gln Ala Arg Ser Phe Val Thr His Pro Asp His Tyr Gln 
                565                 570                 575     


Arg Phe Glu Val Lys Thr Phe Thr Phe Val Ser Gly Thr Pro Ala Leu 
            580                 585                 590         


Ser Ser Leu Val Tyr Phe His Cys Ser Ala Leu Ile Cys Asn Arg Leu 
        595                 600                 605             


Ser Pro Asp Ser Pro Leu Cys Ser Val Thr Cys Pro Gly Ser Pro Arg 
    610                 615                 620                 


Arg Arg Arg Ala Thr Gly Ala Thr Glu Glu Gly Lys Thr Thr Val Ser 
625                 630                 635                 640 


Leu Pro Gly Pro Ile Leu Leu Leu Ser Asp Ser Pro Ser Phe Arg Asp 
                645                 650                 655     


Leu Gly Asp Ser Lys Gly His Glu Thr Thr Glu Asp Val Thr Ser Lys 
            660                 665                 670         


Thr Thr Val Ala Val Ala Ala Ser Ala Gly Val Leu Ala Thr Leu Gly 
        675                 680                 685             


Leu Val Thr Tyr Leu Arg Lys Lys Arg Thr Met Arg Asn Pro 
    690                 695                 700         


