                         SEQUENCE LISTING

<110>  UNIVERSITE D'AIX MARSEILLE
       ASSISTANCE PUBLIQUE-HOPITAUX DE MARSEILLE
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       BADENS, Catherine
       THURET, Isabelle
       GUIZOUARN, Hlne
 
<120>  TREATMENT AND DIAGNOSIS OF HEREDITARY XEROCYTOSIS

<130>  F2245/17-XARA/brvi

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  2240
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (397)..(1680)

<400>  1
gtccttcggt gtctgggtgt ggtgagtaga ggtgtgtgtc acaaagtaca gaccattgtg       60

tgtgacaaag cccatcgtgt gtctgtgtgt gtctttatcc acgtggatgg acgtctcttt      120

cttgctctgc cccaagacac accctagccc ctccttattc tcaaaagggg gagctgggga      180

gcctccccct accctggggc ctcccctgcc cctccccgcc ctgcctggcc gtcaccactc      240

cccagagggc acagggctct gctgtgcctc agagcaaaag tcccagagcc agcagagcag      300

gctgacgacc tgcaagccac agtggctgcc ctgtgcgtgc tgcgaggtgg gggaccctgg      360

gcaggaagct ggctgagccc caagaccccg ggggcc atg ggc ggg gat ctg gtg        414
                                        Met Gly Gly Asp Leu Val           
                                        1               5                 

ctt ggc ctg ggg gcc ttg aga cgc cga aag cgc ttg ctg gag cag gag        462
Leu Gly Leu Gly Ala Leu Arg Arg Arg Lys Arg Leu Leu Glu Gln Glu           
            10                  15                  20                    

aag tct ctg gcc ggc tgg gca ctg gtg ctg gca gga act ggc att gga        510
Lys Ser Leu Ala Gly Trp Ala Leu Val Leu Ala Gly Thr Gly Ile Gly           
        25                  30                  35                        

ctc atg gtg ctg cat gca gag atg ctg tgg ttc ggg ggg tgc tcg tgg        558
Leu Met Val Leu His Ala Glu Met Leu Trp Phe Gly Gly Cys Ser Trp           
    40                  45                  50                            

gcg ctc tac ctg ttc ctg gtt aaa tgc acg atc agc att tcc acc ttc        606
Ala Leu Tyr Leu Phe Leu Val Lys Cys Thr Ile Ser Ile Ser Thr Phe           
55                  60                  65                  70            

tta ctc ctc tgc ctc atc gtg gcc ttt cat gcc aaa gag gtc cag ctg        654
Leu Leu Leu Cys Leu Ile Val Ala Phe His Ala Lys Glu Val Gln Leu           
                75                  80                  85                

ttc atg acc gac aac ggg ctg cgg gac tgg cgc gtg gcg ctg acc ggg        702
Phe Met Thr Asp Asn Gly Leu Arg Asp Trp Arg Val Ala Leu Thr Gly           
            90                  95                  100                   

cgg cag gcg gcg cag atc gtg ctg gag ctg gtg gtg tgt ggg ctg cac        750
Arg Gln Ala Ala Gln Ile Val Leu Glu Leu Val Val Cys Gly Leu His           
        105                 110                 115                       

ccg gcg ccc gtg cgg ggc ccg ccg tgc gtg cag gat tta ggg gcg ccg        798
Pro Ala Pro Val Arg Gly Pro Pro Cys Val Gln Asp Leu Gly Ala Pro           
    120                 125                 130                           

ctg acc tcc ccg cag ccc tgg ccg gga ttc ctg ggc caa ggg gaa gcg        846
Leu Thr Ser Pro Gln Pro Trp Pro Gly Phe Leu Gly Gln Gly Glu Ala           
135                 140                 145                 150           

ctg ctg tcc ctg gcc atg ctg ctg cgt ctc tac ctg gtg ccc cgc gcc        894
Leu Leu Ser Leu Ala Met Leu Leu Arg Leu Tyr Leu Val Pro Arg Ala           
                155                 160                 165               

gtg ctc ctg cgc agc ggc gtc ctg ctc aac gct tcc tac cgc agc atc        942
Val Leu Leu Arg Ser Gly Val Leu Leu Asn Ala Ser Tyr Arg Ser Ile           
            170                 175                 180                   

ggc gct ctc aat caa gtc cgc ttc cgc cac tgg ttc gtg gcc aag ctt        990
Gly Ala Leu Asn Gln Val Arg Phe Arg His Trp Phe Val Ala Lys Leu           
        185                 190                 195                       

tac atg aac acg cac cct ggc cgc ctg ctg ctc ggc ctc acg ctt ggc       1038
Tyr Met Asn Thr His Pro Gly Arg Leu Leu Leu Gly Leu Thr Leu Gly           
    200                 205                 210                           

ctc tgg ctg acc acc gcc tgg gtg ctg tcc gtg gcc gag agg cag gct       1086
Leu Trp Leu Thr Thr Ala Trp Val Leu Ser Val Ala Glu Arg Gln Ala           
215                 220                 225                 230           

gtt aat gcc act ggg cac ctt tca gac aca ctt tgg ctg atc ccc atc       1134
Val Asn Ala Thr Gly His Leu Ser Asp Thr Leu Trp Leu Ile Pro Ile           
                235                 240                 245               

aca ttc ctg acc atc ggc tat ggt gac gtg gtg ccg ggc acc atg tgg       1182
Thr Phe Leu Thr Ile Gly Tyr Gly Asp Val Val Pro Gly Thr Met Trp           
            250                 255                 260                   

ggc aag atc gtc tgc ctg tgc act gga gtc atg ggt gtc tgc tgc aca       1230
Gly Lys Ile Val Cys Leu Cys Thr Gly Val Met Gly Val Cys Cys Thr           
        265                 270                 275                       

gcc ctg ctg gtg gcc gtg gtg gcc cgg aag ctg gag ttt aac aag gca       1278
Ala Leu Leu Val Ala Val Val Ala Arg Lys Leu Glu Phe Asn Lys Ala           
    280                 285                 290                           

gag aag cac gtg cac aac ttc atg atg gat atc cag tat acc aaa gag       1326
Glu Lys His Val His Asn Phe Met Met Asp Ile Gln Tyr Thr Lys Glu           
295                 300                 305                 310           

atg aag gag tcc gct gcc cga gtg cta caa gaa gcc tgg atg ttc tac       1374
Met Lys Glu Ser Ala Ala Arg Val Leu Gln Glu Ala Trp Met Phe Tyr           
                315                 320                 325               

aaa cat act cgc agg aag gag tct cat gct gcc cgc agg cat cag cgc       1422
Lys His Thr Arg Arg Lys Glu Ser His Ala Ala Arg Arg His Gln Arg           
            330                 335                 340                   

aag ctg ctg gcc gcc atc aac gcg ttc cgc cag gtg cgg ctg aaa cac       1470
Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg Gln Val Arg Leu Lys His           
        345                 350                 355                       

cgg aag ctc cgg gaa caa gtg aac tcc atg gtg gac atc tcc aag atg       1518
Arg Lys Leu Arg Glu Gln Val Asn Ser Met Val Asp Ile Ser Lys Met           
    360                 365                 370                           

cac atg atc ctg tat gac ctg cag cag aat ctg agc agc tca cac cgg       1566
His Met Ile Leu Tyr Asp Leu Gln Gln Asn Leu Ser Ser Ser His Arg           
375                 380                 385                 390           

gcc ctg gag aaa cag att gac acg ctg gcg ggg aag ctg gat gcc ctg       1614
Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala Gly Lys Leu Asp Ala Leu           
                395                 400                 405               

act gag ctg ctt agc act gcc ctg ggg ccg agg cag ctt cca gaa ccc       1662
Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro Arg Gln Leu Pro Glu Pro           
            410                 415                 420                   

agc cag cag tcc aag tag ctggacccac gaggaggaac caggctactt              1710
Ser Gln Gln Ser Lys                                                       
        425                                                               

tccccagtac tgaggtggtg gacatcgtct ctgccactcc tgacccagcc ctgaacaaag     1770

cacctcaagt gcaaggacca aagggggccc tggcttggag tgggttggct tgctgatggc     1830

tgctggaggg gacgctggct aaagtgggta ggccttggcc cacctgaggc cccaggtggg     1890

aacatggtca cccccactct gcataccctc atcaaaaaca ctctcactat gctgctatgg     1950

acgacctcca gctctcagtt acaagtgcag gcgactggag gcaggactcc tgggtccctg     2010

ggaaagaggg tactaggggc ccggatccag gattctggga ggcttcagtt accgctggcc     2070

gagctgaaga actgggtatg aggctggggc ggggctggag gtggcgcccc ctggtgggac     2130

aacaaagagg acaccatttt tccagagctg cagagagcac ctggtgggga ggaagaagtg     2190

taactcacca gcctctgctc ttatctttgt aataaatgtt aaagccagaa                2240


<210>  2
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Gly Asp Leu Val Leu Gly Leu Gly Ala Leu Arg Arg Arg Lys 
1               5                   10                  15      


Arg Leu Leu Glu Gln Glu Lys Ser Leu Ala Gly Trp Ala Leu Val Leu 
            20                  25                  30          


Ala Gly Thr Gly Ile Gly Leu Met Val Leu His Ala Glu Met Leu Trp 
        35                  40                  45              


Phe Gly Gly Cys Ser Trp Ala Leu Tyr Leu Phe Leu Val Lys Cys Thr 
    50                  55                  60                  


Ile Ser Ile Ser Thr Phe Leu Leu Leu Cys Leu Ile Val Ala Phe His 
65                  70                  75                  80  


Ala Lys Glu Val Gln Leu Phe Met Thr Asp Asn Gly Leu Arg Asp Trp 
                85                  90                  95      


Arg Val Ala Leu Thr Gly Arg Gln Ala Ala Gln Ile Val Leu Glu Leu 
            100                 105                 110         


Val Val Cys Gly Leu His Pro Ala Pro Val Arg Gly Pro Pro Cys Val 
        115                 120                 125             


Gln Asp Leu Gly Ala Pro Leu Thr Ser Pro Gln Pro Trp Pro Gly Phe 
    130                 135                 140                 


Leu Gly Gln Gly Glu Ala Leu Leu Ser Leu Ala Met Leu Leu Arg Leu 
145                 150                 155                 160 


Tyr Leu Val Pro Arg Ala Val Leu Leu Arg Ser Gly Val Leu Leu Asn 
                165                 170                 175     


Ala Ser Tyr Arg Ser Ile Gly Ala Leu Asn Gln Val Arg Phe Arg His 
            180                 185                 190         


Trp Phe Val Ala Lys Leu Tyr Met Asn Thr His Pro Gly Arg Leu Leu 
        195                 200                 205             


Leu Gly Leu Thr Leu Gly Leu Trp Leu Thr Thr Ala Trp Val Leu Ser 
    210                 215                 220                 


Val Ala Glu Arg Gln Ala Val Asn Ala Thr Gly His Leu Ser Asp Thr 
225                 230                 235                 240 


Leu Trp Leu Ile Pro Ile Thr Phe Leu Thr Ile Gly Tyr Gly Asp Val 
                245                 250                 255     


Val Pro Gly Thr Met Trp Gly Lys Ile Val Cys Leu Cys Thr Gly Val 
            260                 265                 270         


Met Gly Val Cys Cys Thr Ala Leu Leu Val Ala Val Val Ala Arg Lys 
        275                 280                 285             


Leu Glu Phe Asn Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    290                 295                 300                 


Ile Gln Tyr Thr Lys Glu Met Lys Glu Ser Ala Ala Arg Val Leu Gln 
305                 310                 315                 320 


Glu Ala Trp Met Phe Tyr Lys His Thr Arg Arg Lys Glu Ser His Ala 
                325                 330                 335     


Ala Arg Arg His Gln Arg Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg 
            340                 345                 350         


Gln Val Arg Leu Lys His Arg Lys Leu Arg Glu Gln Val Asn Ser Met 
        355                 360                 365             


Val Asp Ile Ser Lys Met His Met Ile Leu Tyr Asp Leu Gln Gln Asn 
    370                 375                 380                 


Leu Ser Ser Ser His Arg Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala 
385                 390                 395                 400 


Gly Lys Leu Asp Ala Leu Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro 
                405                 410                 415     


Arg Gln Leu Pro Glu Pro Ser Gln Gln Ser Lys 
            420                 425         


<210>  3
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  3
cccacaggtt ccgccaggtg cggct                                             25


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe

<400>  4
cccacaggtt ccaccaggtg cggct                                             25


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer forward

<400>  5
agtgctacaa gaagcctgga                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer reverse

<400>  6
tgctaagcag ctcagtcagg                                                   20


<210>  7
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg Gln Val Arg Leu Lys His 
1               5                   10                  15      


Arg Lys Leu Arg Glu Gln 
            20          


<210>  8
<211>  21
<212>  PRT
<213>  Pan troglodytes

<400>  8

Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg Gln Val Arg Leu Lys His 
1               5                   10                  15      


Arg Lys Leu Arg Glu 
            20      


<210>  9
<211>  16
<212>  PRT
<213>  Macaca mulatta

<400>  9

Ile Asn Ala Phe Arg Gln Val Arg Leu Lys His Arg Lys Leu Gln Glu 
1               5                   10                  15      


<210>  10
<211>  18
<212>  PRT
<213>  Felis catus

<400>  10

Arg Leu Leu Ala Ala Ile Asn Arg Phe Arg Gln Val Arg Leu Lys His 
1               5                   10                  15      


Arg Lys 
        


<210>  11
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  11

Lys Met Leu Ala Ala Ile His Thr Phe Arg Gln Val Arg Leu Lys His 
1               5                   10                  15      


Arg Lys 
        


<210>  12
<211>  21
<212>  PRT
<213>  Drosophila melanogaster

<400>  12

Lys Phe Leu Leu Ala Ile Tyr Ala Leu Arg Lys Val Lys Met Asp Gln 
1               5                   10                  15      


Arg Lys Leu Met Asp 
            20      


<210>  13
<211>  16
<212>  PRT
<213>  Caenorhabditis elegans

<400>  13

Lys Phe Leu Leu Ala Ile Tyr Glu Met Arg Arg Val Arg Arg Asp Gln 
1               5                   10                  15      


<210>  14
<211>  21
<212>  PRT
<213>  Xenopus tropicalis

<400>  14

Asn Leu Leu Arg Ala Ile His Val Phe Arg Arg Ser Arg Ile Ser His 
1               5                   10                  15      


Lys Asn Leu Lys Asp 
            20      


