                         SEQUENCE LISTING

<110>  UCB Biopharma SPRL
 
<120>  Antibody

<130>  N400213WO

<150>  GB 1418776.9
<151>  2014-10-22

<150>  GB 1418774.4
<151>  2014-10-22

<150>  GB 1418773.6
<151>  2014-10-22

<150>  GB 1418781.9
<151>  2014-10-22

<150>  GB 1510758.4
<151>  2015-06-18

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 of 1974/1979

<400>  1

Gln Ala Ser Gln Asp Ile Gly Asn 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 of 1974

<400>  2

Gly Ala Thr Ser Leu Ala Asp 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 of 1974

<400>  3

Leu Gln Gly Gln Ser Thr Pro Tyr Thr 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 of 1974

<400>  4

Ala Tyr Tyr Met Ala 
1               5   


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of 1974

<400>  5

Ala Ser Ile Asn Tyr Asp Gly Ala Asn Thr Phe Tyr Arg Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of 1974

<400>  6

Glu Ala Tyr Gly Tyr Asn Ser Asn Trp Phe Gly Tyr 
1               5                   10          


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCVR of 1974

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Pro Ala Ser Pro Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Phe Gly Ile Phe Tyr Cys Leu Gln Gly Gln Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCVR of 1974

<400>  8

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Tyr Asp Gly Ala Asn Thr Phe Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Glu Ala Tyr Gly Tyr Asn Ser Asn Trp Phe Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCVR DNA of 1974

<400>  9
gacatccaga tgacccagtc tcctgcctcc ctgcctgcat ccccggaaga aattgtcacc       60

atcacatgcc aggcaagcca ggacattggt aattggttat catggtatca gcagaaacca      120

gggaaatcgc ctcagctcct gatctatggt gcaaccagct tggcagatgg ggtcccatca      180

aggttcagcg ccagtagatc tggcacacag tactctctta agatcagcag actgcaggtt      240

gaagattttg gaatctttta ctgtctacag ggtcaaagta ctccgtacac gtttggagct      300

gggaccaagc tggaactgaa a                                                321


<210>  10
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCVR DNA of 1974

<400>  10
gacgtgcagc tggtggaatc tggaggaggc ttagtgcagc ctggaaggtc cctgaaactc       60

tcctgtgcag cctcaggatt cactttcagt gcctattaca tggcctgggt ccgccaggct      120

ccaacgaagg gtctggagtg ggtcgcatcc attaattatg atggtgctaa cactttctat      180

cgcgactccg tgaagggccg attcactgtc tccagagata atgcaagaag cagcctatac      240

ctacaaatgg acagtctgag gtctgaggac acggccactt attactgtac aacagaggct      300

tacggatata actcaaattg gtttggttac tggggccaag gcactctggt cactgtctcg      360

agc                                                                    363


<210>  11
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1974 LC kappa full

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Pro Ala Ser Pro Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Phe Gly Ile Phe Tyr Cys Leu Gln Gly Gln Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  12
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1974 HC mIgG1 full

<400>  12

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Tyr Asp Gly Ala Asn Thr Phe Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Glu Ala Tyr Gly Tyr Asn Ser Asn Trp Phe Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    290                 295                 300                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            340                 345                 350         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        355                 360                 365             


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    370                 375                 380                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                405                 410                 415     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445 


<210>  13
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1974 HC mFabno hinge full

<400>  13

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Asn Tyr Asp Gly Ala Asn Thr Phe Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Arg Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Glu Ala Tyr Gly Tyr Asn Ser Asn Trp Phe Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220             


<210>  14
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1974 LC DNA kappa full

<400>  14
gacatccaga tgacccagtc tcctgcctcc ctgcctgcat ccccggaaga aattgtcacc       60

atcacatgcc aggcaagcca ggacattggt aattggttat catggtatca gcagaaacca      120

gggaaatcgc ctcagctcct gatctatggt gcaaccagct tggcagatgg ggtcccatca      180

aggttcagcg ccagtagatc tggcacacag tactctctta agatcagcag actgcaggtt      240

gaagattttg gaatctttta ctgtctacag ggtcaaagta ctccgtacac gtttggagct      300

gggaccaagc tggaactgaa acgtacggat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         642


<210>  15
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1974 HC DNA mIgG1 full

<400>  15
gacgtgcagc tggtggaatc tggaggaggc ttagtgcagc ctggaaggtc cctgaaactc       60

tcctgtgcag cctcaggatt cactttcagt gcctattaca tggcctgggt ccgccaggct      120

ccaacgaagg gtctggagtg ggtcgcatcc attaattatg atggtgctaa cactttctat      180

cgcgactccg tgaagggccg attcactgtc tccagagata atgcaagaag cagcctatac      240

ctacaaatgg acagtctgag gtctgaggac acggccactt attactgtac aacagaggct      300

tacggatata actcaaattg gtttggttac tggggccaag gcactctggt cactgtctcg      360

agtgccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc tgcccaaact      420

aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc agtgacagtg      480

acctggaact ctggatccct gtccagcggt gtgcacacct tcccagctgt cctgcagtct      540

gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc cagcgagacc      600

gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa aattgtgccc      660

agggattgtg gttgtaagcc ttgcatatgt acagtcccag aagtatcatc tgtcttcatc      720

ttccccccaa agcccaagga tgtgctcacc attactctga ctcctaaggt cacgtgtgtt      780

gtggtagaca tcagcaagga tgatcccgag gtccagttca gctggtttgt agatgatgtg      840

gaggtgcaca cagctcagac gcaaccccgg gaggagcagt tcaacagcac tttccgctca      900

gtcagtgaac ttcccatcat gcaccaggac tggctcaatg gcaaggagtt caaatgcagg      960

gtcaacagtg cagctttccc tgcccccatc gagaaaacca tctccaaaac caaaggcaga     1020

ccgaaggctc cacaggtgta caccattcca cctcccaagg agcagatggc caaggataaa     1080

gtcagtctga cctgcatgat aacagacttc ttccctgaag acattactgt ggagtggcag     1140

tggaatgggc agccagcgga gaactacaag aacactcagc ccatcatgga cacagatggc     1200

tcttacttcg tctacagcaa gctcaatgtg cagaagagca actgggaggc aggaaatact     1260

ttcacctgct ctgtgttaca tgagggcctg cacaaccacc atactgagaa gagcctctcc     1320

cactctcctg gtaaa                                                      1335


<210>  16
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1974 HC DNA mFabno hinge full

<400>  16
gacgtgcagc tggtggaatc tggaggaggc ttagtgcagc ctggaaggtc cctgaaactc       60

tcctgtgcag cctcaggatt cactttcagt gcctattaca tggcctgggt ccgccaggct      120

ccaacgaagg gtctggagtg ggtcgcatcc attaattatg atggtgctaa cactttctat      180

cgcgactccg tgaagggccg attcactgtc tccagagata atgcaagaag cagcctatac      240

ctacaaatgg acagtctgag gtctgaggac acggccactt attactgtac aacagaggct      300

tacggatata actcaaattg gtttggttac tggggccaag gcactctggt cactgtctcg      360

agtgccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc tgcccaaact      420

aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc agtgacagtg      480

acctggaact ctggatccct gtccagcggt gtgcacacct tcccggctgt cctgcaatct      540

gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc cagcgagacc      600

gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa aattgtgccc      660

agggattgt                                                              669


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 of 1979

<400>  17

Gly Thr Thr Ser Leu Ala Asp 
1               5           


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 of 1979

<400>  18

Leu Gln Ala Tyr Ser Thr Pro Phe Thr Phe 
1               5                   10  


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 of 1979

<400>  19

Asn Ser Tyr Trp Asp 
1               5   


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 of 1979

<400>  20

Tyr Ile Asn Tyr Ser Gly Ser Thr Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 of 1979

<400>  21

Gly Thr Tyr Gly Tyr Asn Ala Tyr His Phe Asp Tyr 
1               5                   10          


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DIQMTQSPASLSASLEEIVTITCQASQDIGNWLSWYQQKPGKSPHLLIYGTTSLADGVPSRFSGS
       RSGTQYSLKISGLQVADIGIYVCLQAYSTPFTFGSGTKLEIK

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro His Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Gly Leu Gln Val 
65                  70                  75                  80  


Ala Asp Ile Gly Ile Tyr Val Cys Leu Gln Ala Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCVR of 1979

<400>  23

Glu Val His Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Asn Ser 
            20                  25                  30          


Tyr Trp Asp Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Gly Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Asn Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Ile Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Thr Tyr Gly Tyr Asn Ala Tyr His Phe Asp Tyr Trp Gly Arg 
            100                 105                 110         


Gly Val Met Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LCVR DNA of 1979

<400>  24
gacatccaaa tgacacagtc tcctgcctcc ctgtctgcat ctctggaaga aattgtcacc       60

attacatgcc aggcaagcca ggacattggt aattggttat catggtatca gcagaaacca      120

gggaaatctc ctcacctcct gatctatggt accaccagct tggcagatgg ggtcccatca      180

aggttcagcg gcagtagatc tggtacacag tattctctta agatcagcgg actacaggtt      240

gcagatattg gaatctatgt ctgtctacag gcttatagta ctccattcac gttcggctca      300

gggacaaagc tggaaataaa a                                                321


<210>  25
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCVR DNA of 1979

<400>  25
gaggtgcacc tggtggagtc tggacctggc cttgtgaaac cctcacagtc actctccctc       60

acctgttctg tcactggtta ctccatcact aatagttact gggactggat ccggaagttc      120

ccaggaaata aaatggagtg gatgggatac ataaactaca gtggtagcac tggctacaac      180

ccatctctca aaagtcgaat ctccattagt agagacacat cgaacaatca gttcttcctg      240

cagctgaact ctataactac tgaggacaca gccacatatt actgtgcacg agggacctat      300

gggtataacg cctaccactt tgattactgg ggccgaggag tcatggtcac agtctcgagc      360


<210>  26
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1979 LC Kappa full

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro His Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Gly Leu Gln Val 
65                  70                  75                  80  


Ala Asp Ile Gly Ile Tyr Val Cys Leu Gln Ala Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  27
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1979 HC mIgG1 full

<400>  27

Glu Val His Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Asn Ser 
            20                  25                  30          


Tyr Trp Asp Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Gly Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Asn Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Ile Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Thr Tyr Gly Tyr Asn Ala Tyr His Phe Asp Tyr Trp Gly Arg 
            100                 105                 110         


Gly Val Met Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
    210                 215                 220                 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
    290                 295                 300                 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
305                 310                 315                 320 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
            340                 345                 350         


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
        355                 360                 365             


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
    370                 375                 380                 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
385                 390                 395                 400 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
                405                 410                 415     


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
            420                 425                 430         


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 


<210>  28
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1979 HC mFabno hinge full

<400>  28

Glu Val His Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Asn Ser 
            20                  25                  30          


Tyr Trp Asp Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Gly Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Asn Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Ile Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Thr Tyr Gly Tyr Asn Ala Tyr His Phe Asp Tyr Trp Gly Arg 
            100                 105                 110         


Gly Val Met Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220         


<210>  29
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1979 LC DNA Kappa full

<400>  29
gacatccaaa tgacacagtc tcctgcctcc ctgtctgcat ctctggaaga aattgtcacc       60

attacatgcc aggcaagcca ggacattggt aattggttat catggtatca gcagaaacca      120

gggaaatctc ctcacctcct gatctatggt accaccagct tggcagatgg ggtcccatca      180

aggttcagcg gcagtagatc tggtacacag tattctctta agatcagcgg actacaggtt      240

gcagatattg gaatctatgt ctgtctacag gcttatagta ctccattcac gttcggctca      300

gggacaaagc tggaaataaa acgtacggat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         642


<210>  30
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1979 HC DNA mIgG1 full

<400>  30
gaggtgcacc tggtggagtc tggacctggc cttgtgaaac cctcacagtc actctccctc       60

acctgttctg tcactggtta ctccatcact aatagttact gggactggat ccggaagttc      120

ccaggaaata aaatggagtg gatgggatac ataaactaca gtggtagcac tggctacaac      180

ccatctctca aaagtcgaat ctccattagt agagacacat cgaacaatca gttcttcctg      240

cagctgaact ctataactac tgaggacaca gccacatatt actgtgcacg agggacctat      300

gggtataacg cctaccactt tgattactgg ggccgaggag tcatggtcac agtctcgagt      360

gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac      420

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc      480

tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac      540

ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc      600

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg      660

gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc      720

cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg      780

gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag      840

gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc      900

agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc      960

aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg     1020

aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc     1080

agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg     1140

aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct     1200

tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc     1260

acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac     1320

tctcctggta aa                                                         1332


<210>  31
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1979 HC DNA mFabno hinge full

<400>  31
gaggtgcacc tggtggagtc tggacctggc cttgtgaaac cctcacagtc actctccctc       60

acctgttctg tcactggtta ctccatcact aatagttact gggactggat ccggaagttc      120

ccaggaaata aaatggagtg gatgggatac ataaactaca gtggtagcac tggctacaac      180

ccatctctca aaagtcgaat ctccattagt agagacacat cgaacaatca gttcttcctg      240

cagctgaact ctataactac tgaggacaca gccacatatt actgtgcacg agggacctat      300

gggtataacg cctaccactt tgattactgg ggccgaggag tcatggtcac agtctcgagt      360

gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac      420

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc      480

tggaactctg gatccctgtc cagcggtgtg cacaccttcc cggctgtcct gcaatctgac      540

ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc      600

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg      660

gattgt                                                                 666


<210>  32
<211>  235
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Met Gly Gly Leu Gln Asn Ser Arg Arg Cys Leu Cys 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Leu Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu Asn Phe Gly Val Ile Gly Pro Asn Lys Glu Glu Lys Phe 
    50                  55                  60                  


Pro Asn Gly Leu Pro Leu Ile Ser Ser Met Ala Gln Thr Leu Thr Leu 
65                  70                  75                  80  


Arg Ser Ser Ser Gln Asn Ser Ser Asp Lys Pro Val Ala His Val Val 
                85                  90                  95      


Ala Asn His Gln Ala Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala 
            100                 105                 110         


Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val 
        115                 120                 125             


Val Pro Ala Asp Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys 
    130                 135                 140                 


Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg 
145                 150                 155                 160 


Phe Ala Ile Ser Tyr Gln Glu Lys Val Ser Leu Leu Ser Ala Ile Lys 
                165                 170                 175     


Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp 
            180                 185                 190         


Tyr Glu Pro Met Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp 
        195                 200                 205             


Leu Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asp Ile Thr Glu 
    210                 215                 220                 


Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
225                 230                 235 


<210>  33
<211>  235
<212>  PRT
<213>  Mus musculus

<400>  33

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Gln Lys Met Gly Gly Phe Gln Asn Ser Arg Arg Cys Leu Cys 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Leu Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu Asn Phe Gly Val Ile Gly Pro Gln Arg Asp Glu Lys Phe 
    50                  55                  60                  


Pro Asn Gly Leu Pro Leu Ile Ser Ser Met Ala Gln Thr Leu Thr Leu 
65                  70                  75                  80  


Arg Ser Ser Ser Gln Asn Ser Ser Asp Lys Pro Val Ala His Val Val 
                85                  90                  95      


Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala 
            100                 105                 110         


Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val 
        115                 120                 125             


Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys 
    130                 135                 140                 


Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg 
145                 150                 155                 160 


Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys 
                165                 170                 175     


Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp 
            180                 185                 190         


Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp 
        195                 200                 205             


Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asp Phe Ala Glu 
    210                 215                 220                 


Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
225                 230                 235 


<210>  34
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  35
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
1               5                   10                  15      


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
            20                  25                  30          


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
        35                  40                  45              


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
    50                  55                  60                  


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
65                  70                  75                  80  


Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser 
                85                  90                  95      


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala 
            100                 105                 110         


Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu 
        115                 120                 125             


Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp 
    130                 135                 140                 


Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155             


<210>  36
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  36

Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


