                         б

<110>  ѧ
       ɶҩ޹˾
 
<120>  ˷֦˾ԭӦ

<130>  WPI15CN0298X

<150>  CN201510324548.6
<151>  2015-06-15

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  560
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  1

Met Arg Ile Gly Asn Cys Ser Gly Phe Tyr Gly Asp Arg Leu Ser Ala 
1               5                   10                  15      


Met Arg Glu Met Leu Thr Gly Gly Glu Leu Asp Tyr Leu Thr Gly Asp 
            20                  25                  30          


Tyr Leu Ala Glu Leu Thr Met Leu Ile Leu Gly Arg Asp Arg Met Lys 
        35                  40                  45              


Asn Pro Asp Arg Gly Tyr Ala Lys Thr Phe Leu Ala Gln Leu Glu Asp 
    50                  55                  60                  


Cys Leu Gly Leu Ala His Asp Arg Gly Val Arg Ile Val Thr Asn Ala 
65                  70                  75                  80  


Gly Gly Leu Asn Pro Ala Gly Leu Ala Asn Ala Val Arg Ala Leu Ala 
                85                  90                  95      


Ala Arg Leu Gly Ile Pro Ala Gln Val Ala His Val Glu Gly Asp Asp 
            100                 105                 110         


Leu Gln Pro Arg Ala Ala Glu Leu Gly Leu Gly Thr Pro Leu Thr Ala 
        115                 120                 125             


Asn Ala Tyr Leu Gly Ala Trp Gly Ile Val Asp Cys Phe Glu Arg Gly 
    130                 135                 140                 


Ala Asp Val Val Val Thr Gly Arg Val Thr Asp Ala Ser Val Val Val 
145                 150                 155                 160 


Gly Ala Ala Ala Ala His Phe Gly Trp Gly Arg Thr Asp Tyr His Arg 
                165                 170                 175     


Leu Ala Gly Ala Val Val Ala Gly His Val Ile Glu Cys Gly Val Gln 
            180                 185                 190         


Ala Thr Gly Gly Asn Tyr Ala Phe Phe Thr Glu Ile Gly Asp Leu Thr 
        195                 200                 205             


His Ala Gly Phe Pro Leu Ala Glu Ile Ala Ala Asp Gly Ser Ser Val 
    210                 215                 220                 


Ile Thr Lys His His Gly Thr Gly Gly Leu Val Ser Val Asp Thr Ile 
225                 230                 235                 240 


Thr Ala Gln Leu Leu Tyr Glu Ile Thr Gly Ala Arg Tyr Ala Asn Pro 
                245                 250                 255     


Asp Val Thr Ala Arg Met Asp Ser Val Glu Leu Ser Pro Asp Gly Pro 
            260                 265                 270         


Asp Arg Val Arg Ile Ser Gly Val Ile Gly Glu Pro Pro Pro Pro Thr 
        275                 280                 285             


Tyr Lys Val Ser Leu Asn Ser Ile Gly Gly Phe Arg Asn Ala Met Thr 
    290                 295                 300                 


Phe Val Leu Thr Gly Leu Asp Ile Asp Ala Lys Ala Asp Leu Val Arg 
305                 310                 315                 320 


Arg Gln Leu Glu Ala Ala Leu Thr Val Lys Pro Ala Glu Leu Gln Trp 
                325                 330                 335     


Thr Leu Ala Arg Thr Asp His Pro Asp Ala Asp Thr Glu Glu Thr Ala 
            340                 345                 350         


Ser Ala Leu Leu Thr Cys Val Ala Arg Asp Pro Asp Pro Ala Asn Val 
        355                 360                 365             


Gly Arg Gln Phe Ser Ser Ala Ala Val Glu Leu Ala Leu Ala Ser Tyr 
    370                 375                 380                 


Pro Gly Phe Thr Ala Thr Ala Pro Pro Gly Asp Gly Gln Val Tyr Gly 
385                 390                 395                 400 


Val Phe Thr Pro Gly Tyr Val Asp Ala Gly Lys Val Ala His Ile Ala 
                405                 410                 415     


Val His Ala Asp Gly Thr Arg Thr Glu Ile Pro Cys Ala Thr Glu Thr 
            420                 425                 430         


Leu Glu Leu Ala Pro Ala His Pro Pro Ala Leu Pro Asp Pro Leu Pro 
        435                 440                 445             


Ala Gly Pro Thr Arg Arg Val Pro Leu Gly Leu Ile Ala Gly Ala Arg 
    450                 455                 460                 


Ser Gly Asp Lys Gly Gly Ser Ala Asn Val Gly Val Trp Val Arg Thr 
465                 470                 475                 480 


Asp Glu Gln Trp Arg Trp Leu Ala His Thr Leu Thr Val Glu Leu Leu 
                485                 490                 495     


Lys Glu Leu Leu Pro Glu Thr Ala Gly Leu Val Val Thr Arg His Val 
            500                 505                 510         


Leu Pro Asn Leu Arg Ala Leu Asn Phe Val Ile Glu Ala Ile Leu Gly 
        515                 520                 525             


Gln Gly Val Ala Tyr Gln Ala Arg Phe Asp Pro Gln Ala Lys Gly Leu 
    530                 535                 540                 


Gly Glu Trp Leu Arg Ser Arg His Val Glu Ile Pro Glu Thr Leu Leu 
545                 550                 555                 560 


<210>  2
<211>  202
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  2

Met Ala Gly Thr Asp Trp Leu Ser Ala Arg Arg Thr Glu Leu Ala Ala 
1               5                   10                  15      


Asp Arg Ile Leu Asp Ala Ala Glu Arg Leu Phe Thr Gln Arg Asp Pro 
            20                  25                  30          


Ala Ser Ile Gly Met Asn Glu Ile Ala Lys Ala Ala Gly Cys Ser Arg 
        35                  40                  45              


Ala Thr Leu Tyr Arg Tyr Phe Asp Ser Arg Glu Ala Leu Arg Thr Ala 
    50                  55                  60                  


Tyr Val His Arg Glu Thr Arg Arg Leu Gly Arg Glu Ile Met Val Lys 
65                  70                  75                  80  


Ile Ala Asp Val Val Glu Pro Ala Glu Arg Leu Leu Val Ser Ile Thr 
                85                  90                  95      


Thr Thr Leu Arg Met Val Arg Asp Asn Pro Ala Leu Ala Ala Trp Phe 
            100                 105                 110         


Thr Thr Thr Arg Pro Pro Ile Gly Gly Glu Met Ala Gly Arg Ser Glu 
        115                 120                 125             


Val Ile Ala Ala Leu Ala Ala Ala Phe Leu Asn Ser Leu Gly Pro Asp 
    130                 135                 140                 


Asp Pro Thr Thr Val Glu Arg Arg Ala Arg Trp Val Val Arg Met Leu 
145                 150                 155                 160 


Thr Ser Leu Leu Met Phe Pro Gly Arg Asp Glu Ala Asp Glu Arg Ala 
                165                 170                 175     


Met Ile Ala Glu Phe Val Val Pro Ile Val Thr Pro Ala Ser Ala Ala 
            180                 185                 190         


Ala Arg Lys Ala Gly His Pro Gly Pro Glu 
        195                 200         


<210>  3
<211>  213
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  3

Met Pro Arg Gln Ala Gly Arg Trp Ser Pro Thr Ala Leu Arg Ile Leu 
1               5                   10                  15      


Gly Ala Ala Ala Glu Leu Ile Ala Leu Arg Gly Tyr Ser Ser Thr Ser 
            20                  25                  30          


Thr Arg Asp Ile Ala Ala Ala Val Gly Val Glu Gln Pro Ala Ile Tyr 
        35                  40                  45              


Lys His Phe Ser Ala Lys Arg Asp Ile Leu Ala Ala Leu Val Arg Leu 
    50                  55                  60                  


Ala Val Glu Trp Pro Leu Glu Leu Phe Gly His Ile Thr Ala Met Pro 
65                  70                  75                  80  


Val Pro Ala Val Val Lys Leu His Arg Trp Leu Thr Glu Ser Leu Asp 
                85                  90                  95      


His Leu His Ala Ser Pro Tyr Val Leu Val Ser Ile Leu Ile Thr Pro 
            100                 105                 110         


Asp Leu His Gln Glu Ser Phe Val Ala Glu Arg Glu Leu Val Ala Glu 
        115                 120                 125             


Met Glu Arg Ala Leu Val Gly Leu Ile Glu Thr Gly Gln Gly Glu Gly 
    130                 135                 140                 


Asp Val Arg Ala Met His Pro Leu Ser Ala Ala Arg Leu Val Gln Ala 
145                 150                 155                 160 


Leu Phe Asp Ala Leu Ala Leu Pro Glu Phe Ala Val Ser Pro Asp Glu 
                165                 170                 175     


Ile Val Glu Phe Ala Met Thr Ala Leu Leu Ser Asp Pro Asp Arg Leu 
            180                 185                 190         


Ala Glu Ile Arg Ala Ala Ala Asp Ala Leu Glu Ile Gln Thr Ala Pro 
        195                 200                 205             


Pro Asp Arg Gly Leu 
    210             


<210>  4
<211>  269
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  4

Met Thr Ser Val Lys Leu Asp Leu Asp Ala Ala Asp Leu Arg Ile Ser 
1               5                   10                  15      


Arg Gly Ser Val Pro Ala Ser Thr Gln Leu Ala Glu Ala Leu Lys Ala 
            20                  25                  30          


Gln Ile Ile Gln Gln Arg Leu Pro Arg Gly Gly Arg Leu Pro Ser Glu 
        35                  40                  45              


Arg Glu Leu Ile Asp Arg Ser Gly Leu Ser Arg Val Thr Val Arg Ala 
    50                  55                  60                  


Ala Val Gly Met Leu Gln Arg Gln Gly Trp Leu Val Arg Arg Gln Gly 
65                  70                  75                  80  


Leu Gly Thr Phe Val Ala Asp Pro Val Glu Gln Glu Leu Ser Cys Gly 
                85                  90                  95      


Val Arg Thr Ile Thr Glu Val Leu Leu Ser Cys Gly Val Thr Pro Gln 
            100                 105                 110         


Val Asp Val Leu Ser His Gln Thr Gly Pro Ala Pro Gln Arg Ile Ser 
        115                 120                 125             


Glu Thr Leu Gly Leu Val Glu Val Leu Cys Ile Arg Arg Arg Ile Arg 
    130                 135                 140                 


Thr Gly Asp Gln Pro Leu Ala Leu Val Thr Ala Tyr Leu Pro Pro Gly 
145                 150                 155                 160 


Val Gly Pro Ala Val Glu Pro Leu Leu Ser Gly Ser Ala Asp Thr Glu 
                165                 170                 175     


Thr Thr Tyr Ala Met Trp Glu Arg Arg Leu Gly Val Arg Ile Ala Gln 
            180                 185                 190         


Ala Thr His Glu Ile His Ala Ala Gly Ala Ser Pro Asp Val Ala Asp 
        195                 200                 205             


Ala Leu Gly Leu Ala Val Gly Ser Pro Val Leu Val Val Asp Arg Thr 
    210                 215                 220                 


Ser Tyr Thr Asn Asp Gly Lys Pro Leu Glu Val Val Val Phe His His 
225                 230                 235                 240 


Arg Pro Glu Arg Tyr Gln Phe Ser Val Thr Leu Pro Arg Thr Leu Pro 
                245                 250                 255     


Gly Ser Gly Ala Gly Ile Ile Glu Lys Arg Asp Phe Ala 
            260                 265                 


<210>  5
<211>  1682
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  5
gtgcgtatcg gaaactgctc gggcttctac ggcgaccgcc tctccgccat gcgcgagatg       60

ctgaccggcg gcgagctgga ctatctcacc ggcgactacc tggccgagct gaccatgttg      120

attctcggtc gcgaccgcat gaaaaacccc gatcgcggct acgcgaagac cttcctggcc      180

cagctcgagg actgcctggg cctggcccat gaccgcgggg tgcgcatcgt caccaacgcc      240

ggtggcctga accccgccgg gctggccaac gcggtgcggg cgctggccgc gcgcctgggc      300

attccggcgc aggtcgccca cgtggaaggc gacgacctgc aaccacgggc ggccgaactg      360

gggctgggga cgccactgac ggccaacgcc tacctgggcg catggggcat cgtcgactgc      420

ttcgagcgcg gcgccgacgt cgtggtcacc ggccgggtca ccgacgcctc ggtggtcgtc      480

ggggcggcgg ccgcgcactt cggctggggc cgcaccgact accaccgact ggccggcgcc      540

gtggtggccg ggcacgtgat cgaatgcgga gtccaggcca ccggcggcaa ctacgcgttc      600

ttcaccgaga taggcgacct cactcacgcc ggcttcccgc tggccgagat cgctgccgac      660

ggctcgtcgg tgatcaccaa gcaccacggc accggcggcc tggtcagcgt cgacaccatc      720

accgcgcagc tgctctacga gatcacgggc gctcggtatg ccaacccgga tgtgacggcc      780

cggatggaca gcgtcgaact gtcgcccgac gggccggatc gagtgcgcat tagcggcgtg      840

atcggcgaac cgccgccgcc gacctacaag gtgtcgctga acagcatcgg cggcttccgc      900

aacgccatga cattcgtgct gaccggcctg gacatcgatg ccaaggccga cttggtgcga      960

cgccagctcg aggccgcgct gaccgtcaaa cccgctgagc tgcaatggac gctggcccgc     1020

accgaccacc ccgacgccga caccgaagaa accgccagcg cgctgctcac ctgcgtcgcc     1080

cgcgatcccg accctgccaa tgtgggtcgg caattctcct cggccgcggt cgaattggcg     1140

ctggccagct acccggggtt caccgccacc gccccgcccg gtgacgccag gtgtatggcg     1200

tgttcacccc cggctacgtc gacgccggca aggtggcgca catcgccgtg cacgccgacg     1260

gcacccgcac cgagattccc tgcgccactg agacgttgga gctggcgccg gcacatcccc     1320

cggcgctgcc cgacccgctg ccggctggcc cgacccggcg cgtaccgctg ggcctgatcg     1380

ctggcgcccg cagcggcgac aagggcggat cggccaacgt cggcgtgtgg gtacgcaccg     1440

acgagcagtg gcgctggctg gcgcacacgc tgaccgtcga gctactcaag gagctgctgc     1500

cagaaacggc aggcctggtc gtcacccgtc acgtgctgcc gaatctgcgg gcactgaact     1560

tcgtcatcga ggcaatcctc ggccagggcg tcgcctacca ggcccgcttc gacccgcagg     1620

ccaagggact gggtgagtgg ctgcgcagcc gccacgtcga gatcccggag accctgttgt     1680

ga                                                                    1682


<210>  6
<211>  609
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  6
atggcgggta ccgactggct gtccgcgcgt cggaccgagt tagccgcaga tcggatactc       60

gacgccgccg agcgactctt tacgcagcgt gacccggcgt cgatcggcat gaacgagatc      120

gccaaggccg caggctgttc gcgcgcaaca ctgtatcggt acttcgacag ccgcgaggcg      180

ctgcgaaccg cgtacgtgca ccgcgagacc cgccggctcg gccgcgagat catggtgaag      240

atcgccgatg tcgtcgaacc tgccgaacgg ctgctggtga gcatcaccac gacgttgcgg      300

atggtccgcg acaaccccgc gttggccgcg tggtttacca ccacccgccc accgatcggc      360

ggcgagatgg ccggacggtc cgaggtgatc gcggccctgg ccgcggcatt cctcaactca      420

ctaggtcccg acgatccgac caccgtcgaa cgccgcgccc gctgggtggt ccggatgctc      480

acatcgctgc tgatgttccc cggccgtgac gaagccgacg aacgagcgat gatcgcggag      540

ttcgtcgtcc cgatcgtgac acctgcttct gccgccgcta ggaaggccgg tcaccctgga      600

cccgagtga                                                              609


<210>  7
<211>  642
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  7
atgccgaggc aggccggccg ctggagccca acggcactcc gcatcctggg ggccgctgcc       60

gagctcatcg cgctgcgggg ttacagctcc acctcgacgc gagacattgc cgcagccgtc      120

ggggtggagc agccggccat ctacaaacac ttctcggcca aacgcgatat ccttgcggcc      180

ctggtgcggc tcgccgtgga gtggccgctt gagctgttcg gtcacatcac cgcgatgccg      240

gttccggcgg tggtcaagct gcaccgctgg ctgacggaat ccctggacca cctgcatgct      300

tcgccctatg tgctggtttc catcctcatc accccggacc tgcatcagga atccttcgtc      360

gcggagcggg agctagtcgc ggagatggaa cgcgcgctgg ttggcctgat cgagaccggc      420

caaggcgaag gtgatgtgcg cgcaatgcat ccgttatcgg ctgccaggct ggtgcaggcg      480

ttgtttgacg ctctggcgct gccggaattc gcggtcagcc cggacgagat cgtcgagttc      540

gcgatgacgg cgctgttgtc ggaccctgat cggctagccg agatccgggc agcagcagat      600

gctttggaga tccagaccgc accccccgac cgcgggctct ag                         642


<210>  8
<211>  810
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  8
atgacatctg tcaagctgga cctggacgct gccgatctgc ggatatcgcg tggcagcgtg       60

ccggcgagta cccagcttgc cgaggcgcta aaggcccaga tcatccagca gcggctgccg      120

cgcggcgggc gcttgcccag cgaacgagaa ttgatcgacc gttccggttt gagccgcgtg      180

accgtgcgcg cggcggtcgg catgctgcaa cgtcagggat ggctagtgcg ccggcaaggc      240

ttgggtacct tcgtcgccga tccggtggaa caggagctca gttgcggcgt gcgcaccatc      300

acagaggtgt tgttgagctg tggtgttacc ccgcaggtcg acgtgctgtc acaccagacc      360

ggaccggcgc cgcaacggat ttccgagacg ctgggtttgg ttgaggtcct ctgtattcgc      420

cggcgcatcc gcactggcga tcaacccttg gccctggtca cggcctatct tccgcccggc      480

gtgggcccag ccgtcgagcc gttgctatcg ggcagcgcgg acaccgaaac cacatatgcg      540

atgtgggagc ggcgactggg tgtacgcatt gcacaggcta cccacgaaat ccatgccgcc      600

ggggcctccc ccgacgtagc cgacgcgttg ggtctggcgg tgggttcgcc ggtactggtc      660

gtcgaccgca ccagctacac caatgacggc aagccccttg aagtggtcgt gttccaccat      720

cgccccgagc ggtaccagtt ctccgtcacg ttaccccgaa cgttgcccgg atcaggtgcc      780

ggaattatcg agaaacgaga tttcgcatga                                       810


<210>  9
<211>  338
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  9

Met Gln Leu Val Asp Arg Val Arg Gly Ala Val Thr Gly Met Ser Arg 
1               5                   10                  15      


Arg Leu Val Val Gly Ala Val Gly Ala Ala Leu Val Ser Gly Leu Val 
            20                  25                  30          


Gly Ala Val Gly Gly Thr Ala Thr Ala Gly Ala Phe Ser Arg Pro Gly 
        35                  40                  45              


Leu Pro Val Glu Tyr Leu Gln Val Pro Ser Pro Ser Met Gly Arg Asp 
    50                  55                  60                  


Ile Lys Val Gln Phe Gln Ser Gly Gly Ala Asn Ser Pro Ala Leu Tyr 
65                  70                  75                  80  


Leu Leu Asp Gly Leu Arg Ala Gln Asp Asp Phe Ser Gly Trp Asp Ile 
                85                  90                  95      


Asn Thr Pro Ala Phe Glu Trp Tyr Asp Gln Ser Gly Leu Ser Val Val 
            100                 105                 110         


Met Pro Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp Tyr Gln Pro 
        115                 120                 125             


Ala Cys Gly Lys Ala Gly Cys Gln Thr Tyr Lys Trp Glu Thr Phe Leu 
    130                 135                 140                 


Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn Arg His Val Lys Pro 
145                 150                 155                 160 


Thr Gly Ser Ala Val Val Gly Leu Ser Met Ala Ala Ser Ser Ala Leu 
                165                 170                 175     


Thr Leu Ala Ile Tyr His Pro Gln Gln Phe Val Tyr Ala Gly Ala Met 
            180                 185                 190         


Ser Gly Leu Leu Asp Pro Ser Gln Ala Met Gly Pro Thr Leu Ile Gly 
        195                 200                 205             


Leu Ala Met Gly Asp Ala Gly Gly Tyr Lys Ala Ser Asp Met Trp Gly 
    210                 215                 220                 


Pro Lys Glu Asp Pro Ala Trp Gln Arg Asn Asp Pro Leu Leu Asn Val 
225                 230                 235                 240 


Gly Lys Leu Ile Ala Asn Asn Thr Arg Val Trp Val Tyr Cys Gly Asn 
                245                 250                 255     


Gly Lys Pro Ser Asp Leu Gly Gly Asn Asn Leu Pro Ala Lys Phe Leu 
            260                 265                 270         


Glu Gly Phe Val Arg Thr Ser Asn Ile Lys Phe Gln Asp Ala Tyr Asn 
        275                 280                 285             


Ala Gly Gly Gly His Asn Gly Val Phe Asp Phe Pro Asp Ser Gly Thr 
    290                 295                 300                 


His Ser Trp Glu Tyr Trp Gly Ala Gln Leu Asn Ala Met Lys Pro Asp 
305                 310                 315                 320 


Leu Gln Arg Ala Leu Gly Ala Thr Pro Asn Thr Gly Pro Ala Pro Gln 
                325                 330                 335     


Gly Ala 
        


<210>  10
<211>  1017
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  10
atgcagcttg ttgacagggt tcgtggcgcc gtcacgggta tgtcgcgtcg actcgtggtc       60

ggggccgtcg gcgcggccct agtgtcgggt ctggtcggcg ccgtcggtgg cacggcgacc      120

gcgggggcat tttcccggcc gggcttgccg gtggagtacc tgcaggtgcc gtcgccgtcg      180

atgggccgtg acatcaaggt ccaattccaa agtggtggtg ccaactcgcc cgccctgtac      240

ctgctcgacg gcctgcgcgc gcaggacgac ttcagcggct gggacatcaa caccccggcg      300

ttcgagtggt acgaccagtc gggcctgtcg gtggtcatgc cggtgggtgg ccagtcaagc      360

ttctactccg actggtacca gcccgcctgc ggcaaggccg gttgccagac ttacaagtgg      420

gagaccttcc tgaccagcga gctgccgggg tggctgcagg ccaacaggca cgtcaagccc      480

accggaagcg ccgtcgtcgg tctttcgatg gctgcttctt cggcgctgac gctggcgatc      540

tatcaccccc agcagttcgt ctacgcggga gcgatgtcgg gcctgttgga cccctcccag      600

gcgatgggtc ccaccctgat cggcctggcg atgggtgacg ctggcggcta caaggcctcc      660

gacatgtggg gcccgaagga ggacccggcg tggcagcgca acgacccgct gttgaacgtc      720

gggaagctga tcgccaacaa cacccgcgtc tgggtgtact gcggcaacgg caagccgtcg      780

gatctgggtg gcaacaacct gccggccaag ttcctcgagg gcttcgtgcg gaccagcaac      840

atcaagttcc aagacgccta caacgccggt ggcggccaca acggcgtgtt cgacttcccg      900

gacagcggta cgcacagctg ggagtactgg ggcgcgcagc tcaacgctat gaagcccgac      960

ctgcaacggg cactgggtgc cacgcccaac accgggcccg cgccccaggg cgcctag        1017


<210>  11
<211>  391
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  11

Met Val Asp Phe Gly Ala Leu Pro Pro Glu Ile Asn Ser Ala Arg Met 
1               5                   10                  15      


Tyr Ala Gly Pro Gly Ser Ala Ser Leu Val Ala Ala Ala Gln Met Trp 
            20                  25                  30          


Asp Ser Val Ala Ser Asp Leu Phe Ser Ala Ala Ser Ala Phe Gln Ser 
        35                  40                  45              


Val Val Trp Gly Leu Thr Val Gly Ser Trp Ile Gly Ser Ser Ala Gly 
    50                  55                  60                  


Leu Met Val Ala Ala Ala Ser Pro Tyr Val Ala Trp Met Ser Val Thr 
65                  70                  75                  80  


Ala Gly Gln Ala Glu Leu Thr Ala Ala Gln Val Arg Val Ala Ala Ala 
                85                  90                  95      


Ala Tyr Glu Thr Ala Tyr Gly Leu Thr Val Pro Pro Pro Val Ile Ala 
            100                 105                 110         


Glu Asn Arg Ala Glu Leu Met Ile Leu Ile Ala Thr Asn Leu Leu Gly 
        115                 120                 125             


Gln Asn Thr Pro Ala Ile Ala Val Asn Glu Ala Glu Tyr Gly Glu Met 
    130                 135                 140                 


Trp Ala Gln Asp Ala Ala Ala Met Phe Gly Tyr Ala Ala Ala Thr Ala 
145                 150                 155                 160 


Thr Ala Thr Ala Thr Leu Leu Pro Phe Glu Glu Ala Pro Glu Met Thr 
                165                 170                 175     


Ser Ala Gly Gly Leu Leu Glu Gln Ala Ala Ala Val Glu Glu Ala Ser 
            180                 185                 190         


Asp Thr Ala Ala Ala Asn Gln Leu Met Asn Asn Val Pro Gln Ala Leu 
        195                 200                 205             


Gln Gln Leu Ala Gln Pro Thr Gln Gly Thr Thr Pro Ser Ser Lys Leu 
    210                 215                 220                 


Gly Gly Leu Trp Lys Thr Val Ser Pro His Arg Ser Pro Ile Ser Asn 
225                 230                 235                 240 


Met Val Ser Met Ala Asn Asn His Met Ser Met Thr Asn Ser Gly Val 
                245                 250                 255     


Ser Met Thr Asn Thr Leu Ser Ser Met Leu Lys Gly Phe Ala Pro Ala 
            260                 265                 270         


Ala Ala Ala Gln Ala Val Gln Thr Ala Ala Gln Asn Gly Val Arg Ala 
        275                 280                 285             


Met Ser Ser Leu Gly Ser Ser Leu Gly Ser Ser Gly Leu Gly Gly Gly 
    290                 295                 300                 


Val Ala Ala Asn Leu Gly Arg Ala Ala Ser Val Gly Ser Leu Ser Val 
305                 310                 315                 320 


Pro Gln Ala Trp Ala Ala Ala Asn Gln Ala Val Thr Pro Ala Ala Arg 
                325                 330                 335     


Ala Leu Pro Leu Thr Ser Leu Thr Ser Ala Ala Glu Arg Gly Pro Gly 
            340                 345                 350         


Gln Met Leu Gly Gly Leu Pro Val Gly Gln Met Gly Ala Arg Ala Gly 
        355                 360                 365             


Gly Gly Leu Ser Gly Val Leu Arg Val Pro Pro Arg Pro Tyr Val Met 
    370                 375                 380                 


Pro His Ser Pro Ala Ala Gly 
385                 390     


<210>  12
<211>  1176
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  12
atggtggatt tcggggcgtt accaccggag atcaactccg cgaggatgta cgccggcccg       60

ggttcggcct cgctggtggc cgcggctcag atgtgggaca gcgtggcgag tgacctgttt      120

tcggccgcgt cggcgtttca gtcggtggtc tggggtctga cggtggggtc gtggataggt      180

tcgtcggcgg gtctgatggt ggcggcggcc tcgccgtatg tggcgtggat gagcgtcacc      240

gcggggcagg ccgagctgac cgccgcccag gtccgggttg ctgcggcggc ctacgagacg      300

gcgtatgggc tgacggtgcc cccgccggtg atcgccgaga accgtgctga actgatgatt      360

ctgatagcga ccaacctctt ggggcaaaac accccggcga tcgcggtcaa cgaggccgaa      420

tacggcgaga tgtgggccca agacgccgcc gcgatgtttg gctacgccgc ggcgacggcg      480

acggcgacgg cgacgttgct gccgttcgag gaggcgccgg agatgaccag cgcgggtggg      540

ctcctcgagc aggccgccgc ggtcgaggag gcctccgaca ccgccgcggc gaaccagttg      600

atgaacaatg tgccccaggc gctgcaacag ctggcccagc ccacgcaggg caccacgcct      660

tcttccaagc tgggtggcct gtggaagacg gtctcgccgc atcggtcgcc gatcagcaac      720

atggtgtcga tggccaacaa ccacatgtcg atgaccaact cgggtgtgtc gatgaccaac      780

accttgagct cgatgttgaa gggctttgct ccggcggcgg ccgcccaggc cgtgcaaacc      840

gcggcgcaaa acggggtccg ggcgatgagc tcgctgggca gctcgctggg ttcttcgggt      900

ctgggcggtg gggtggccgc caacttgggt cgggcggcct cggtcggttc gttgtcggtg      960

ccgcaggcct gggccgcggc caaccaggca gtcaccccgg cggcgcgggc gctgccgctg     1020

accagcctga ccagcgccgc ggaaagaggg cccgggcaga tgctgggcgg gctgccggtg     1080

gggcagatgg gcgccagggc cggtggtggg ctcagtggtg tgctgcgtgt tccgccgcga     1140

ccctatgtga tgccgcattc tccggcggcc ggctag                               1176


<210>  13
<211>  144
<212>  PRT
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  13

Met Ala Thr Thr Leu Pro Val Gln Arg His Pro Arg Ser Leu Phe Pro 
1               5                   10                  15      


Glu Phe Ser Glu Leu Phe Ala Ala Phe Pro Ser Phe Ala Gly Leu Arg 
            20                  25                  30          


Pro Thr Phe Asp Thr Arg Leu Met Arg Leu Glu Asp Glu Met Lys Glu 
        35                  40                  45              


Gly Arg Tyr Glu Val Arg Ala Glu Leu Pro Gly Val Asp Pro Asp Lys 
    50                  55                  60                  


Asp Val Asp Ile Met Val Arg Asp Gly Gln Leu Thr Ile Lys Ala Glu 
65                  70                  75                  80  


Arg Thr Glu Gln Lys Asp Phe Asp Gly Arg Ser Glu Phe Ala Tyr Gly 
                85                  90                  95      


Ser Phe Val Arg Thr Val Ser Leu Pro Val Gly Ala Asp Glu Asp Asp 
            100                 105                 110         


Ile Lys Ala Thr Tyr Asp Lys Gly Ile Leu Thr Val Ser Val Ala Val 
        115                 120                 125             


Ser Glu Gly Lys Pro Thr Glu Lys His Ile Gln Ile Arg Ser Thr Asn 
    130                 135                 140                 


<210>  14
<211>  435
<212>  DNA
<213>  ˷֦˾Mycobacterium tuberculosis

<400>  14
atggccacca cccttcccgt tcagcgccac ccgcggtccc tcttccccga gttttctgag       60

ctgttcgcgg ccttcccgtc attcgccgga ctccggccca ccttcgacac ccggttgatg      120

cggctggaag acgagatgaa agaggggcgc tacgaggtac gcgcggagct tcccggggtc      180

gaccccgaca aggacgtcga cattatggtc cgcgatggtc agctgaccat caaggccgag      240

cgcaccgagc agaaggactt cgacggtcgc tcggaattcg cgtacggttc cttcgttcgc      300

acggtgtcgc tgccggtagg tgctgacgag gacgacatta aggccaccta cgacaagggc      360

attcttactg tgtcggtggc ggtttcggaa gggaagccaa ccgaaaagca cattcagatc      420

cggtccacca actga                                                       435


<210>  15
<211>  29
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  15
taggatccgt gcgtatcgga aactgctcg                                         29


<210>  16
<211>  32
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  16
tagaagcttt cacaacaggg tctccgggat ct                                     32


<210>  17
<211>  30
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  17
catggatcca tggcgggtac cgactggctg                                        30


<210>  18
<211>  29
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  18
ctgaagcttt cactcgggtc cagggtgac                                         29


<210>  19
<211>  32
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  19
cgtggatcca tgccgaggca ggccggccgc tg                                     32


<210>  20
<211>  34
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  20
gcaaagcttc tagagcccgc ggtcgggggg tgcg                                   34


<210>  21
<211>  31
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  21
tatggatcca tgacatctgt caagctggac c                                      31


<210>  22
<211>  31
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  22
gcgaagcttt catgcgaaat ctcgtttctc g                                      31


<210>  23
<211>  51
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  23
ataatactta aggccgccac catgcagctt gttgacaggg ttcgtggcgc c                51


<210>  24
<211>  53
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  24
ataattctag atcaatggtg atggtgatgg gcgccctggg gcgcgggccc ggt              53


<210>  25
<211>  51
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  25
ataatactta aggccgccac catggtggat ttcggggcgt taccaccgga g                51


<210>  26
<211>  50
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  26
ataattctag atcaatggtg atggtgatgg ccggccgccg gagaatgcgg                  50


<210>  27
<211>  42
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  27
atatacttaa ggccgccacc atggccacca cccttcccgt tc                          42


<210>  28
<211>  59
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  28
aatattctag atcaatggtg atggtgatga tggttggtgg accggatctg aatgtgctt        59


<210>  29
<211>  37
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  29
tagaattcgc caccatgggc atgcgtatcg gaaactg                                37


<210>  30
<211>  44
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  30
taactgcagc tagtgatggt gatggtgatg caacagggtc tccg                        44


<210>  31
<211>  43
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  31
atatacttaa ggccgccacc atggcgggta ccgactggct gtc                         43


<210>  32
<211>  53
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  32
aatattctag atcaatggtg atggtgatga tgctcgggtc cagggtgacc ggc              53


<210>  33
<211>  40
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  33
atatacttaa ggccgccacc atgccgaggc aggccggccg                             40


<210>  34
<211>  52
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  34
aatatctcga gtcaatggtg atggtgatga tggagcccgc ggtcgggggg tg               52


<210>  35
<211>  47
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  35
atatacttaa ggccgccacc atgacatctg tcaagctgga cctggac                     47


<210>  36
<211>  62
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  36
aatattctag atcaatggtg atggtgatga tgtgcgaaat ctcgtttctc gataattccg       60

gc                                                                      62


