                         SEQUENCE LISTING

<110>  	Noskov, Sergei
	Durdagi, Serdar
	Duff, Henry

<120>  SYSTEMS AND METHODS OF SELECTING COMPOUNDS WITH REDUCED RISK OF 
CARDIOTOXICITY USING HERG MODELS

<130>  13449-006-228

<140>  To Be Assigned
<141>  Herewith

<150>  62/181,169
<151>  2015-06-17

<160>  2    

<170>  PatentIn version 3.5

<210>  1
<211>  3480
<212>  DNA
<213>  Homosapiens
<220>
<223>  hERG1 (also known as KCNH2, Kv11.1, HERG1, erg1, LQT2, SQT1)


<400>  1
atgccggtgc ggaggggcca cgtcgcgccg cagaacacct tcctggacac catcatccgc       60

aagtttgagg gccagagccg taagttcatc atcgccaacg ctcgggtgga gaactgcgcc      120

gtcatctact gcaacgacgg cttctgcgag ctgtgcggct actcgcgggc cgaggtgatg      180

cagcgaccct gcacctgcga cttcctgcac gggccgcgca cgcagcgccg cgctgccgcg      240

cagatcgcgc aggcactgct gggcgccgag gagcgcaaag tggaaatcgc cttctaccgg      300

aaagatggga gctgcttcct atgtctggtg gatgtggtgc ccgtgaagaa cgaggatggg      360

gctgtcatca tgttcatcct caatttcgag gtggtgatgg agaaggacat ggtggggtcc      420

ccggctcatg acaccaacca ccggggcccc cccaccagct ggctggcccc aggccgcgcc      480

aagaccttcc gcctgaagct gcccgcgctg ctggcgctga cggcccggga gtcgtcggtg      540

cggtcgggcg gcgcgggcgg cgcgggcgcc ccgggggccg tggtggtgga cgtggacctg      600

acgcccgcgg cacccagcag cgagtcgctg gccctggacg aagtgacagc catggacaac      660

cacgtggcag ggctcgggcc cgcggaggag cggcgtgcgc tggtgggtcc cggctctccg      720

ccccgcagcg cgcccggcca gctcccatcg ccccgggcgc acagcctcaa ccccgacgcc      780

tcgggctcca gctgcagcct ggcccggacg cgctcccgag aaagctgcgc cagcgtgcgc      840

cgcgcctcgt cggccgacga catcgaggcc atgcgcgccg gggtgctgcc cccgccaccg      900

cgccacgcca gcaccggggc catgcaccca ctgcgcagcg gcttgctcaa ctccacctcg      960

gactccgacc tcgtgcgcta ccgcaccatt agcaagattc cccaaatcac cctcaacttt     1020

gtggacctca agggcgaccc cttcttggct tcgcccacca gtgaccgtga gatcatagca     1080

cctaagataa aggagcgaac ccacaatgtc actgagaagg tcacccaggt cctgtccctg     1140

ggcgccgacg tgctgcctga gtacaagctg caggcaccgc gcatccaccg ctggaccatc     1200

ctgcattaca gccccttcaa ggccgtgtgg gactggctca tcctgctgct ggtcatctac     1260

acggctgtct tcacacccta ctcggctgcc ttcctgctga aggagacgga agaaggcccg     1320

cctgctaccg agtgtggcta cgcctgccag ccgctggctg tggtggacct catcgtggac     1380

atcatgttca ttgtggacat cctcatcaac ttccgcacca cctacgtcaa tgccaacgag     1440

gaggtggtca gccaccccgg ccgcatcgcc gtccactact tcaagggctg gttcctcatc     1500

gacatggtgg ccgccatccc cttcgacctg ctcatcttcg gctctggctc tgaggagctg     1560

atcgggctgc tgaagactgc gcggctgctg cggctggtgc gcgtggcgcg gaagctggat     1620

cgctactcag agtacggcgc ggccgtgctg ttcttgctca tgtgcacctt tgcgctcatc     1680

gcgcactggc tagcctgcat ctggtacgcc atcggcaaca tggagcagcc acacatggac     1740

tcacgcatcg gctggctgca caacctgggc gaccagatag gcaaacccta caacagcagc     1800

ggcctgggcg gcccctccat caaggacaag tatgtgacgg cgctctactt caccttcagc     1860

agcctcacca gtgtgggctt cggcaacgtc tctcccaaca ccaactcaga gaagatcttc     1920

tccatctgcg tcatgctcat tggctccctc atgtatgcta gcatcttcgg caacgtgtcg     1980

gccatcatcc agcggctgta ctcgggcaca gcccgctacc acacacagat gctgcgggtg     2040

cgggagttca tccgcttcca ccagatcccc aatcccctgc gccagcgcct cgaggagtac     2100

ttccagcacg cctggtccta caccaacggc atcgacatga acgcggtgct gaagggcttc     2160

cctgagtgcc tgcaggctga catctgcctg cacctgaacc gctcactgct gcagcactgc     2220

aaacccttcc gaggggccac caagggctgc cttcgggccc tggccatgaa gttcaagacc     2280

acacatgcac cgccagggga cacactggtg catgctgggg acctgctcac cgccctgtac     2340

ttcatctccc ggggctccat cgagatcctg cggggcgacg tcgtcgtggc catcctgggg     2400

aagaatgaca tctttgggga gcctctgaac ctgtatgcaa ggcctggcaa gtcgaacggg     2460

gatgtgcggg ccctcaccta ctgtgaccta cacaagatcc atcgggacga cctgctggag     2520

gtgctggaca tgtaccctga gttctccgac cacttctggt ccagcctgga gatcaccttc     2580

aacctgcgag ataccaacat gatcccgggc tcccccggca gtacggagtt agagggtggc     2640

ttcagtcggc aacgcaagcg caagttgtcc ttccgcaggc gcacggacaa ggacacggag     2700

cagccagggg aggtgtcggc cttggggccg ggccgggcgg gggcagggcc gagtagccgg     2760

ggccggccgg gggggccgtg gggggagagc ccgtccagtg gcccctccag ccctgagagc     2820

agtgaggatg agggcccagg ccgcagctcc agccccctcc gcctggtgcc cttctccagc     2880

cccaggcccc ccggagagcc gccgggtggg gagcccctga tggaggactg cgagaagagc     2940

agcgacactt gcaaccccct gtcaggcgcc ttctcaggag tgtccaacat tttcagcttc     3000

tggggggaca gtcggggccg ccagtaccag gagctccctc gatgccccgc ccccaccccc     3060

agcctcctca acatccccct ctccagcccg ggtcggcggc cccggggcga cgtggagagc     3120

aggctggatg ccctccagcg ccagctcaac aggctggaga cccggctgag tgcagacatg     3180

gccactgtcc tgcagctgct acagaggcag atgacgctgg tcccgcccgc ctacagtgct     3240

gtgaccaccc cggggcctgg ccccacttcc acatccccgc tgttgcccgt cagccccctc     3300

cccaccctca ccttggactc gctttctcag gtttcccagt tcatggcgtg tgaggagctg     3360

cccccggggg ccccagagct tccccaagaa ggccccacac gacgcctctc cctaccgggc     3420

cagctggggg ccctcacctc ccagcccctg cacagacacg gctcggaccc gggcagttag     3480


<210>  2
<211>  1159
<212>  PRT
<213>  Homosapiens
<220>  
<223>  hERG1 (also known as KCNH2, Kv11.1, HERG1, erg1, LQT2, SQT1)

<400>  2

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


