                         SEQUENCE LISTING

<110>  WALFISH, Paul G.
       RALHAN, Ranju
 
<120>  METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF A THYROID CONDITION

<130>  78602/00080

<140>  PCT/CA2016/
<141>  2016-06-10 

<150>  US 14/738,867
<151>  2015-06-13

<150>  US 14/476,222
<151>  2014-09-03

<150>  US 13/102,638
<151>  2011-05-06

<150>  US 61/332,381
<151>  2010-05-07

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Arg Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  2
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Thr Glu Ala 
            580             


<210>  3
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr Glu Asp 
1               5                   10                  15      


Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly Arg Asp 
            20                  25                  30          


Ala Pro Ala His Gly Asn Ala Asn Glu Glu Asn Gly Glu Pro Glu Ala 
        35                  40                  45              


Asp Asn Glu Val Asp Glu Glu Glu Glu Glu Gly Gly Glu Glu Glu Gly 
    50                  55                  60                  


Asp Gly Glu Glu Glu Asp Gly Asp Glu Asp Glu Gly Ala Glu Ser Ala 
65                  70                  75                  80  


Thr Gly Lys Arg Ala Ala Glu Asp Asp Glu Asp Asp Asp Val Asp Thr 
                85                  90                  95      


Gln Lys Gln Lys Thr Asp Glu Asp Asp 
            100                 105 


<210>  4
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Arg Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Val Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Ile Lys Leu Val Val Glu Trp 
        115                 120                 125             


Gln Leu Gln Asp Asp Lys Asn Gln Ser Leu Phe Cys Trp Glu Ile Pro 
    130                 135                 140                 


Val Gln Ile Val Ser His Leu 
145                 150     


<210>  5
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  6
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  7
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ala Thr Gly Thr Ala Ala Ala Ala Ala Thr Gly Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Gly Leu Thr Ala Pro Ala Leu Ala Leu Ala Gly 
            20                  25                  30          


Tyr Ile Glu Ala Leu Ala Ala Asn Ala Gly Thr Gly Phe Ala Val Ala 
        35                  40                  45              


Glu Pro Gln Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Val Asn 
    50                  55                  60                  


Ile Gln Thr Gly Lys Trp Glu Pro Asp Pro Thr Gly Thr Lys Ser Cys 
65                  70                  75                  80  


Phe Glu Thr Lys Glu Glu Val Leu Gln Tyr Cys Gln Glu Met Tyr Pro 
                85                  90                  95      


Glu Leu Gln Ile Thr Asn Val Met Glu Ala Asn Gln Arg Val Ser Ile 
            100                 105                 110         


Asp Asn Trp Cys Arg Arg Asp Lys Lys Gln Cys Lys Ser Arg Phe Val 
        115                 120                 125             


Thr Pro Phe Lys Cys Leu Val Pro Pro Thr Pro Leu Pro Thr Asn Asp 
    130                 135                 140                 


Val Asp Val Tyr Phe Glu Thr Ser Ala Asp Asp Asn Glu His Ala Arg 
145                 150                 155                 160 


Phe Gln Lys Ala Lys Glu Gln Leu Glu Ile Arg His Arg Asn Arg Met 
                165                 170                 175     


Asp Arg Val Lys Lys Glu Trp Glu Glu Ala Glu Leu Gln Ala Lys Asn 
            180                 185                 190         


Leu Pro Lys Ala Glu Arg Gln Thr Leu Ile Gln His Phe Gln Ala Met 
        195                 200                 205             


Val Lys Ala Leu Glu Lys Glu Ala Ala Ser Glu Lys Gln Gln Leu Val 
    210                 215                 220                 


Glu Thr His Leu Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg 
225                 230                 235                 240 


Met Ala Leu Glu Asn Tyr Leu Ala Ala Leu Gln Ser Asp Pro Pro Arg 
                245                 250                 255     


Pro His Arg Ile Leu Gln Ala Leu Arg Arg Tyr Val Arg Ala Glu Asn 
            260                 265                 270         


Lys Asp Arg Leu His Thr Ile Arg His Tyr Gln His Val Leu Ala Val 
        275                 280                 285             


Asp Pro Glu Lys Ala Ala Gln Met Lys Ser Gln Val Met Thr His Leu 
    290                 295                 300                 


His Val Ile Glu Glu Arg Arg Asn Gln Thr Leu Ser Leu Leu Tyr Lys 
305                 310                 315                 320 


Val Pro Tyr Val Ala Gln Glu Ile Gln Glu Glu Ile Asp Glu Leu Leu 
                325                 330                 335     


Gln Glu Gln Arg Ala Asp Met Asp Gln Phe Thr Ala Ser Ile Ser Glu 
            340                 345                 350         


Thr Pro Val Asp Val Arg Val Ser Ser Glu Glu Ser Glu Glu Ile Pro 
        355                 360                 365             


Pro Phe His Pro Phe His Pro Phe Pro Ala Leu Pro Glu Asn Glu Gly 
    370                 375                 380                 


Ser Gly Val Gly Glu Gln Asp Gly Gly Leu Ile Gly Ala Glu Glu Lys 
385                 390                 395                 400 


Val Ile Asn Ser Lys Asn Lys Val Asp Glu Asn Met Val Ile Asp Glu 
                405                 410                 415     


Thr Leu Asp Val Lys Glu Met Ile Phe Asn Ala Glu Arg Val Gly Gly 
            420                 425                 430         


Leu Glu Glu Glu Arg Glu Ser Val Gly Pro Leu Arg Glu Asp Phe Ser 
        435                 440                 445             


Leu Ser Ser Ser Ala Leu Ile Gly Leu Leu Val Ile Ala Val Ala Ile 
    450                 455                 460                 


Ala Thr Val Ile Val Ile Ser Leu Val Met Leu Arg Lys Arg Gln Tyr 
465                 470                 475                 480 


Gly Thr Ile Ser His Gly Ile Val Glu Val Asp Pro Met Leu Thr Pro 
                485                 490                 495     


Glu Glu Arg His Leu Asn Lys Met Gln Asn His Gly Tyr Glu Asn Pro 
            500                 505                 510         


Thr Tyr Lys Tyr Leu Glu Gln Met Gln Ile 
        515                 520         


<210>  8
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys 
1               5                   10                  15      


Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu 
            20                  25                  30          


Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile 
        35                  40                  45              


Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val 
    50                  55                  60                  


Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys 
65                  70                  75                  80  


Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys 
                85                  90                  95      


Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala 
            100                 105                 110         


Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala 
        115                 120                 125             


Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp 
    130                 135                 140                 


Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys 
                165                 170                 175     


Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu 
        195                 200                 205             


Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val 
    210                 215                 220                 


Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu 
225                 230                 235                 240 


Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp 
                245                 250                 255     


Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro 
            260                 265                 270         


Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys 
        275                 280                 285             


Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr 
    290                 295                 300                 


Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala 
305                 310                 315                 320 


Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu 
                325                 330                 335     


Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val 
            340                 345                 350         


Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly 
        355                 360                 365             


Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys 
    370                 375                 380                 


Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu 
385                 390                 395                 400 


Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala 
                405                 410                 415     


Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala 
            420                 425                 430         


Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu 
        435                 440                 445             


Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr 
    450                 455                 460                 


Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr 
465                 470                 475                 480 


Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser 
                485                 490                 495     


Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile 
            500                 505                 510         


Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile 
        515                 520                 525             


Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn 
    530                 535                 540                 


Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro 
545                 550                 555                 560 


Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val 
                565                 570                 575     


Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe 
            580                 585                 590         


Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser 
        595                 600                 605             


Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys 
    610                 615                 620                 


Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val 
625                 630                 635                 640 


Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg 
                645                 650                 655     


Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly 
            660                 665                 670         


Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly 
        675                 680                 685             


Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly 
    690                 695                 700                 


Lys Lys Thr Lys Phe Glu 
705                 710 


<210>  9
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
1               5                   10                  15      


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Phe Ile Thr Leu 
            20                  25                  30          


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
        35                  40                  45              


Glu 
    


<210>  10
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
65                  70                  75                  80  


Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                85                  90                  95      


Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
    130                 135                 140                 


Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
        195                 200                 205             


Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Gly Gly Glu Asn 
                245 


<210>  11
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Ala Gln Ala Ala Lys Val Ser Lys Lys Glu Leu Asn Ser Asn 
1               5                   10                  15      


His Asp Gly Ala Asp Glu Thr Ser Glu Lys Glu Gln Gln Glu Ala Ile 
            20                  25                  30          


Glu His Ile Asp Glu Val Gln Asn Glu Ile Asp Arg Leu Asn Glu Gln 
        35                  40                  45              


Ala Ser Glu Glu Ile Leu Lys Val Glu Gln Lys Tyr Asn Lys Leu Arg 
    50                  55                  60                  


Gln Pro Phe Phe Gln Lys Arg Ser Glu Leu Ile Ala Lys Ile Pro Asn 
65                  70                  75                  80  


Phe Trp Val Thr Thr Phe Val Asn His Pro Gln Val Ser Ala Leu Leu 
                85                  90                  95      


Gly Glu Glu Asp Glu Glu Ala Leu His Tyr Leu Thr Arg Val Glu Val 
            100                 105                 110         


Thr Glu Phe Glu Asp Ile Lys Ser Gly Tyr Arg Ile Asp Phe Tyr Phe 
        115                 120                 125             


Asp Glu Asn Pro Tyr Phe Glu Asn Lys Val Leu Ser Lys Glu Phe His 
    130                 135                 140                 


Leu Asn Glu Ser Gly Asp Pro Ser Ser Lys Ser Thr Glu Ile Lys Trp 
145                 150                 155                 160 


Lys Ser Gly Lys Asp Leu Thr Lys Arg Ser Ser Gln Thr Gln Asn Lys 
                165                 170                 175     


Ala Ser Arg Lys Arg Gln His Glu Glu Pro Glu Ser Phe Phe Thr Trp 
            180                 185                 190         


Phe Thr Asp His Ser Asp Ala Gly Ala Asp Glu Leu Gly Glu Val Ile 
        195                 200                 205             


Lys Asp Asp Ile Trp Pro Asn Pro Leu Gln Tyr Tyr Leu Val Pro Asp 
    210                 215                 220                 


Met Asp Asp Glu Glu Gly Glu Gly Glu Glu Asp Asp Asp Asp Asp Glu 
225                 230                 235                 240 


Glu Glu Glu Gly Leu Glu Asp Ile Asp Glu Glu Gly Asp Glu Asp Glu 
                245                 250                 255     


Gly Glu Glu Asp Glu Asp Asp Asp Glu Gly Glu Glu Gly Glu Glu Asp 
            260                 265                 270         


Glu Gly Glu Asp Asp 
        275         


<210>  12
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Lys Pro His Ser Glu Ala Gly Thr Ala Phe Ile Gln Thr Gln 
1               5                   10                  15      


Gln Leu His Ala Ala Met Ala Asp Thr Phe Leu Glu His Met Cys Arg 
            20                  25                  30          


Leu Asp Ile Asp Ser Pro Pro Ile Thr Ala Arg Asn Thr Gly Ile Ile 
        35                  40                  45              


Cys Thr Ile Gly Pro Ala Ser Arg Ser Val Glu Thr Leu Lys Glu Met 
    50                  55                  60                  


Ile Lys Ser Gly Met Asn Val Ala Arg Leu Asn Phe Ser His Gly Thr 
65                  70                  75                  80  


His Glu Tyr His Ala Glu Thr Ile Lys Asn Val Arg Thr Ala Thr Glu 
                85                  90                  95      


Ser Phe Ala Ser Asp Pro Ile Leu Tyr Arg Pro Val Ala Val Ala Leu 
            100                 105                 110         


Asp Thr Lys Gly Pro Glu Ile Arg Thr Gly Leu Ile Lys Gly Ser Gly 
        115                 120                 125             


Thr Ala Glu Val Glu Leu Lys Lys Gly Ala Thr Leu Lys Ile Thr Leu 
    130                 135                 140                 


Asp Asn Ala Tyr Met Glu Lys Cys Asp Glu Asn Ile Leu Trp Leu Asp 
145                 150                 155                 160 


Tyr Lys Asn Ile Cys Lys Val Val Glu Val Gly Ser Lys Ile Tyr Val 
                165                 170                 175     


Asp Asp Gly Leu Ile Ser Leu Gln Val Lys Arg Lys Gly Ala Asp Phe 
            180                 185                 190         


Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly Ser Lys Lys Gly 
        195                 200                 205             


Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala Val Ser Glu Lys 
    210                 215                 220                 


Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp Val Asp Met Val 
225                 230                 235                 240 


Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val Arg Glu Val Arg Lys 
                245                 250                 255     


Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile Ser Lys Ile Glu 
            260                 265                 270         


Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu Glu Ala Ser Asp 
        275                 280                 285             


Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu Ile Pro Ala Glu 
    290                 295                 300                 


Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg Cys Asn Arg Ala 
305                 310                 315                 320 


Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu Ser Met Ile Lys 
                325                 330                 335     


Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val Ala Asn Ala Val 
            340                 345                 350         


Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu Thr Ala Lys Gly 
        355                 360                 365             


Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu Ile Ala Arg Glu 
    370                 375                 380                 


Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu Glu Leu Arg Arg 
385                 390                 395                 400 


Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr Ala Val Gly Ala 
                405                 410                 415     


Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile Ile Val Leu Thr 
            420                 425                 430         


Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr Arg Pro Arg Ala 
        435                 440                 445             


Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala Arg Gln Ala His 
    450                 455                 460                 


Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp Pro Val Gln Glu 
465                 470                 475                 480 


Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe Ala Met Asn Val 
                485                 490                 495     


Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val Val Ile Val Leu 
            500                 505                 510         


Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr Met Arg Val Val 
        515                 520                 525             


Pro Val Pro 
    530     


<210>  13
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Tyr Gln 
            100                 105                 110         


His Tyr Lys Gly Ser Asp Phe Asp Cys Glu Leu Arg Leu Leu Ile His 
        115                 120                 125             


Gln Ser Leu Ala Gly Gly Ile Ile Gly Val Lys Gly Ala Lys Ile Lys 
    130                 135                 140                 


Glu Leu Arg Glu Asn Thr Gln Thr Thr Ile Lys Leu Phe Gln Glu Cys 
145                 150                 155                 160 


Cys Pro His Ser Thr Asp Arg Val Val Leu Ile Gly Gly Lys Pro Asp 
                165                 170                 175     


Arg Val Val Glu Cys Ile Lys Ile Ile Leu Asp Leu Ile Ser Glu Ser 
            180                 185                 190         


Pro Ile Lys Gly Arg Ala Gln Pro Tyr Asp Pro Asn Phe Tyr Asp Glu 
        195                 200                 205             


Thr Tyr Asp Tyr Gly Gly Phe Thr Met Met Phe Asp Asp Arg Arg Gly 
    210                 215                 220                 


Arg Pro Val Gly Phe Pro Met Arg Gly Arg Gly Gly Phe Asp Arg Met 
225                 230                 235                 240 


Pro Pro Gly Arg Gly Gly Arg Pro Met Pro Pro Ser Arg Arg Asp Tyr 
                245                 250                 255     


Asp Asp Met Ser Pro Arg Arg Gly Pro Pro Pro Pro Pro Pro Gly Arg 
            260                 265                 270         


Gly Gly Arg Gly Gly Ser Arg Ala Arg Asn Leu Pro Leu Pro Pro Pro 
        275                 280                 285             


Pro Pro Pro Arg Gly Gly Asp Leu Met Ala Tyr Asp Arg Arg Gly Arg 
    290                 295                 300                 


Pro Gly Asp Arg Tyr Asp Gly Met Val Gly Phe Ser Ala Asp Glu Thr 
305                 310                 315                 320 


Trp Asp Ser Ala Ile Asp Thr Trp Ser Pro Ser Glu Trp Gln Met Ala 
                325                 330                 335     


Tyr Glu Pro Gln Gly Gly Ser Gly Tyr Asp Tyr Ser Tyr Ala Gly Gly 
            340                 345                 350         


Arg Gly Ser Tyr Gly Asp Leu Gly Gly Pro Ile Ile Thr Thr Gln Val 
        355                 360                 365             


Thr Ile Pro Lys Asp Leu Ala Gly Ser Ile Ile 
    370                 375                 


<210>  14
<211>  971
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Arg Arg Pro Ala Pro Ala Leu Ala Pro Ala Ala Arg Leu Leu 
1               5                   10                  15      


Leu Ala Gly Leu Leu Cys Gly Gly Gly Val Trp Ala Ala Arg Val Asn 
            20                  25                  30          


Lys His Lys Pro Trp Leu Glu Pro Thr Tyr His Gly Ile Val Thr Glu 
        35                  40                  45              


Asn Asp Asn Thr Val Leu Leu Asp Pro Pro Leu Ile Ala Leu Asp Lys 
    50                  55                  60                  


Asp Ala Pro Leu Arg Phe Ala Gly Glu Ile Cys Gly Phe Lys Ile His 
65                  70                  75                  80  


Gly Gln Asn Val Pro Phe Asp Ala Val Val Val Asp Lys Ser Thr Gly 
                85                  90                  95      


Glu Gly Val Ile Arg Ser Lys Glu Lys Leu Asp Cys Glu Leu Gln Lys 
            100                 105                 110         


Asp Tyr Ser Phe Thr Ile Gln Ala Tyr Asp Cys Gly Lys Gly Pro Asp 
        115                 120                 125             


Gly Thr Asn Val Lys Lys Ser His Lys Ala Thr Val His Ile Gln Val 
    130                 135                 140                 


Asn Asp Val Asn Glu Tyr Ala Pro Val Phe Lys Glu Lys Ser Tyr Lys 
145                 150                 155                 160 


Ala Thr Val Ile Glu Gly Lys Gln Tyr Asp Ser Ile Leu Arg Val Glu 
                165                 170                 175     


Ala Val Asp Ala Asp Cys Ser Pro Gln Phe Ser Gln Ile Cys Ser Tyr 
            180                 185                 190         


Glu Ile Ile Thr Pro Asp Val Pro Phe Thr Val Asp Lys Asp Gly Tyr 
        195                 200                 205             


Ile Lys Asn Thr Glu Lys Leu Asn Tyr Gly Lys Glu His Gln Tyr Lys 
    210                 215                 220                 


Leu Thr Val Thr Ala Tyr Asp Cys Gly Lys Lys Arg Ala Thr Glu Asp 
225                 230                 235                 240 


Val Leu Val Lys Ile Ser Ile Lys Pro Thr Cys Thr Pro Gly Trp Gln 
                245                 250                 255     


Gly Trp Asn Asn Arg Ile Glu Tyr Glu Pro Gly Thr Gly Ala Leu Ala 
            260                 265                 270         


Val Phe Pro Asn Ile His Leu Glu Thr Cys Asp Glu Pro Val Ala Ser 
        275                 280                 285             


Val Gln Ala Thr Val Glu Leu Glu Thr Ser His Ile Gly Lys Gly Cys 
    290                 295                 300                 


Asp Arg Asp Thr Tyr Ser Glu Lys Ser Leu His Arg Leu Cys Gly Ala 
305                 310                 315                 320 


Ala Ala Gly Thr Ala Glu Leu Leu Pro Ser Pro Ser Gly Ser Leu Asn 
                325                 330                 335     


Trp Thr Met Gly Leu Pro Thr Asp Asn Gly His Asp Ser Asp Gln Val 
            340                 345                 350         


Phe Glu Phe Asn Gly Thr Gln Ala Val Arg Ile Pro Asp Gly Val Val 
        355                 360                 365             


Ser Val Ser Pro Lys Glu Pro Phe Thr Ile Ser Val Trp Met Arg His 
    370                 375                 380                 


Gly Pro Phe Gly Arg Lys Lys Glu Thr Ile Leu Cys Ser Ser Asp Lys 
385                 390                 395                 400 


Thr Asp Met Asn Arg His His Tyr Ser Leu Tyr Val His Gly Cys Arg 
                405                 410                 415     


Leu Ile Phe Leu Phe Arg Gln Asp Pro Ser Glu Glu Lys Lys Tyr Arg 
            420                 425                 430         


Pro Ala Glu Phe His Trp Lys Leu Asn Gln Val Cys Asp Glu Glu Trp 
        435                 440                 445             


His His Tyr Val Leu Asn Val Glu Phe Pro Ser Val Thr Leu Tyr Val 
    450                 455                 460                 


Asp Gly Thr Ser His Glu Pro Phe Ser Val Thr Glu Asp Tyr Pro Leu 
465                 470                 475                 480 


His Pro Ser Lys Ile Glu Thr Gln Leu Val Val Gly Ala Cys Trp Gln 
                485                 490                 495     


Glu Phe Ser Gly Val Glu Asn Asp Asn Glu Thr Glu Pro Val Thr Val 
            500                 505                 510         


Ala Ser Ala Gly Gly Asp Leu His Met Thr Gln Phe Phe Arg Gly Asn 
        515                 520                 525             


Leu Ala Gly Leu Thr Leu Arg Ser Gly Lys Leu Ala Asp Lys Lys Val 
    530                 535                 540                 


Ile Asp Cys Leu Tyr Thr Cys Lys Glu Gly Leu Asp Leu Gln Val Leu 
545                 550                 555                 560 


Glu Asp Ser Gly Arg Gly Val Gln Ile Gln Ala His Pro Ser Gln Leu 
                565                 570                 575     


Val Leu Thr Leu Glu Gly Glu Asp Leu Gly Glu Leu Asp Lys Ala Met 
            580                 585                 590         


Gln His Ile Ser Tyr Leu Asn Ser Arg Gln Phe Pro Thr Pro Gly Ile 
        595                 600                 605             


Arg Arg Leu Lys Ile Thr Ser Thr Ile Lys Cys Phe Asn Glu Ala Thr 
    610                 615                 620                 


Cys Ile Ser Val Pro Pro Val Asp Gly Tyr Val Met Val Leu Gln Pro 
625                 630                 635                 640 


Glu Glu Pro Lys Ile Ser Leu Ser Gly Val His His Phe Ala Arg Ala 
                645                 650                 655     


Ala Ser Glu Phe Glu Ser Ser Glu Gly Val Phe Leu Phe Pro Glu Leu 
            660                 665                 670         


Arg Ile Ile Ser Thr Ile Thr Arg Glu Val Glu Pro Glu Gly Asp Gly 
        675                 680                 685             


Ala Glu Asp Pro Thr Val Gln Glu Ser Leu Val Ser Glu Glu Ile Val 
    690                 695                 700                 


His Asp Leu Asp Thr Cys Glu Val Thr Val Glu Gly Glu Glu Leu Asn 
705                 710                 715                 720 


His Glu Gln Glu Ser Leu Glu Val Asp Met Ala Arg Leu Gln Gln Lys 
                725                 730                 735     


Gly Ile Glu Val Ser Ser Ser Glu Leu Gly Met Thr Phe Thr Gly Val 
            740                 745                 750         


Asp Thr Met Ala Ser Tyr Glu Glu Val Leu His Leu Leu Arg Tyr Arg 
        755                 760                 765             


Asn Trp His Ala Arg Ser Leu Leu Asp Arg Lys Phe Lys Leu Ile Cys 
    770                 775                 780                 


Ser Glu Leu Asn Gly Arg Tyr Ile Ser Asn Glu Phe Lys Val Glu Val 
785                 790                 795                 800 


Asn Val Ile His Thr Ala Asn Pro Met Glu His Ala Asn His Met Ala 
                805                 810                 815     


Ala Gln Pro Gln Phe Val His Pro Glu His Arg Ser Phe Val Asp Leu 
            820                 825                 830         


Ser Gly His Asn Leu Ala Asn Pro His Pro Phe Ala Val Val Pro Ser 
        835                 840                 845             


Thr Ala Thr Val Val Ile Val Val Cys Val Ser Phe Leu Val Phe Met 
    850                 855                 860                 


Ile Ile Leu Gly Val Phe Arg Ile Arg Ala Ala His Arg Arg Thr Met 
865                 870                 875                 880 


Arg Asp Gln Asp Thr Gly Lys Glu Asn Glu Met Asp Trp Asp Asp Ser 
                885                 890                 895     


Ala Leu Thr Ile Thr Val Asn Pro Met Glu Thr Tyr Glu Asp Gln His 
            900                 905                 910         


Ser Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Ser Glu Asp 
        915                 920                 925             


Gly Glu Glu Glu Asp Asp Ile Thr Ser Ala Glu Ser Glu Ser Ser Glu 
    930                 935                 940                 


Glu Glu Glu Gly Glu Gln Gly Asp Pro Gln Asn Ala Thr Arg Gln Gln 
945                 950                 955                 960 


Gln Leu Glu Trp Asp Asp Ser Thr Leu Ser Tyr 
                965                 970     


<210>  15
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gln Arg Leu Gly Ala Thr Leu Leu Cys Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Val Pro Thr Ala Pro Ala Pro Ala Pro Thr Ala Thr Ser Ala Pro Val 
            20                  25                  30          


Lys Pro Gly Pro Ala Leu Ser Tyr Pro Gln Glu Glu Ala Thr Leu Asn 
        35                  40                  45              


Glu Met Phe Arg Glu Val Glu Glu Leu Val Glu Asp Thr Gln His Lys 
    50                  55                  60                  


Leu Arg Ser Ala Val Glu Glu Met Glu Ala Glu Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Ala Ser Ser Glu Val Asn Leu Ala Asn Leu Pro Pro Ser Tyr His Asn 
                85                  90                  95      


Glu Thr Asn Thr Asp Thr Lys Val Gly Asn Asn Thr Ile His Val His 
            100                 105                 110         


Arg Glu Ile His Lys Ile Thr Asn Asn Gln Ala Arg Gln Met Val Phe 
        115                 120                 125             


Ser Glu Thr Val Ile Thr Ser Val Gly Asp Glu Glu Gly Arg Arg Ser 
    130                 135                 140                 


His Glu Cys Ile Ile Asp Glu Asp Cys Gly Pro Ser Met Tyr Cys Gln 
145                 150                 155                 160 


Phe Ala Ser Phe Gln Tyr Thr Cys Gln Pro Cys Arg Gly Gln Arg Met 
                165                 170                 175     


Leu Cys Thr Arg Asp Ser Glu Cys Cys Gly Asp Gln Leu Cys Val Trp 
            180                 185                 190         


Gly His Cys Thr Lys Met Ala Thr Arg Gly Ser Asn Gly Thr Ile Cys 
        195                 200                 205             


Asp Asn Gln Arg Asp Cys Gln Pro Gly Leu Cys Cys Ala Phe Gln Arg 
    210                 215                 220                 


Gly Leu Leu Phe Pro Val Cys Ile Pro Leu Pro Val Glu Gly Glu Leu 
225                 230                 235                 240 


Cys His Asp Pro Ala Ser Arg Leu Leu Asp Leu Ile Thr Trp Glu Leu 
                245                 250                 255     


Glu Pro Asp Gly Ala Leu Asp Arg Cys Pro Cys Ala Ser Gly Leu Leu 
            260                 265                 270         


Cys Gln Pro His Ser His Ser Leu Val Tyr Val Cys Lys Pro Thr Phe 
        275                 280                 285             


Val Gly Ser Arg Asp Gln Asp Gly Glu Ile Leu Leu Pro Arg Glu Val 
    290                 295                 300                 


Pro Asp Glu Tyr Glu Val Gly Ser Phe Met Glu Glu Val Arg Gln Glu 
305                 310                 315                 320 


Leu Glu Asp Leu Glu Arg Ser Leu Thr Glu Glu Met Ala Leu Gly Glu 
                325                 330                 335     


Pro Ala Ala Ala Ala Ala Ala Leu Leu Gly Gly Glu Glu Ile 
            340                 345                 350 


<210>  16
<211>  1247
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Ala Ser Ser Ser Arg Ile Arg Ala Ala Trp Thr Arg Ala Leu 
1               5                   10                  15      


Leu Leu Pro Leu Leu Leu Ala Gly Pro Val Gly Cys Leu Ser Arg Gln 
            20                  25                  30          


Glu Leu Phe Pro Phe Gly Pro Gly Gln Gly Asp Leu Glu Leu Glu Asp 
        35                  40                  45              


Gly Asp Asp Phe Val Ser Pro Ala Leu Glu Leu Ser Gly Ala Leu Arg 
    50                  55                  60                  


Phe Tyr Asp Arg Ser Asp Ile Asp Ala Val Tyr Val Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Ile Ala Thr Ser Glu Pro Pro Ala Lys Glu Ser His Pro Gly Leu 
                85                  90                  95      


Phe Pro Pro Thr Phe Gly Ala Val Ala Pro Phe Leu Ala Asp Leu Asp 
            100                 105                 110         


Thr Thr Asp Gly Leu Gly Lys Val Tyr Tyr Arg Glu Asp Leu Ser Pro 
        115                 120                 125             


Ser Ile Thr Gln Arg Ala Ala Glu Cys Val His Arg Gly Phe Pro Glu 
    130                 135                 140                 


Ile Ser Phe Gln Pro Ser Ser Ala Val Val Val Thr Trp Glu Ser Val 
145                 150                 155                 160 


Ala Pro Tyr Gln Gly Pro Ser Arg Asp Pro Asp Gln Lys Gly Lys Arg 
                165                 170                 175     


Asn Thr Phe Gln Ala Val Leu Ala Ser Ser Asp Ser Ser Ser Tyr Ala 
            180                 185                 190         


Ile Phe Leu Tyr Pro Glu Asp Gly Leu Gln Phe His Thr Thr Phe Ser 
        195                 200                 205             


Lys Lys Glu Asn Asn Gln Val Pro Ala Val Val Ala Phe Ser Gln Gly 
    210                 215                 220                 


Ser Val Gly Phe Leu Trp Lys Ser Asn Gly Ala Tyr Asn Ile Phe Ala 
225                 230                 235                 240 


Asn Asp Arg Glu Ser Val Glu Asn Leu Ala Lys Ser Ser Asn Ser Gly 
                245                 250                 255     


Gln Gln Gly Val Trp Val Phe Glu Ile Gly Ser Pro Ala Thr Thr Asn 
            260                 265                 270         


Gly Val Val Pro Ala Asp Val Ile Leu Gly Thr Glu Asp Gly Ala Glu 
        275                 280                 285             


Tyr Asp Asp Glu Asp Glu Asp Tyr Asp Leu Ala Thr Thr Arg Leu Gly 
    290                 295                 300                 


Leu Glu Asp Val Gly Thr Thr Pro Phe Ser Tyr Lys Ala Leu Arg Arg 
305                 310                 315                 320 


Gly Gly Ala Asp Thr Tyr Ser Val Pro Ser Val Leu Ser Pro Arg Arg 
                325                 330                 335     


Ala Ala Thr Glu Arg Pro Leu Gly Pro Pro Thr Glu Arg Thr Arg Ser 
            340                 345                 350         


Phe Gln Leu Ala Val Glu Thr Phe His Gln Gln His Pro Gln Val Ile 
        355                 360                 365             


Asp Val Asp Glu Val Glu Glu Thr Gly Val Val Phe Ser Tyr Asn Thr 
    370                 375                 380                 


Asp Ser Arg Gln Thr Cys Ala Asn Asn Arg His Gln Cys Ser Val His 
385                 390                 395                 400 


Ala Glu Cys Arg Asp Tyr Ala Thr Gly Phe Cys Cys Ser Cys Val Ala 
                405                 410                 415     


Gly Tyr Thr Gly Asn Gly Arg Gln Cys Val Ala Glu Gly Ser Pro Gln 
            420                 425                 430         


Arg Val Asn Gly Lys Val Lys Gly Arg Ile Phe Val Gly Ser Ser Gln 
        435                 440                 445             


Val Pro Ile Val Phe Glu Asn Thr Asp Leu His Ser Tyr Val Val Met 
    450                 455                 460                 


Asn His Gly Arg Ser Tyr Thr Ala Ile Ser Thr Ile Pro Glu Thr Val 
465                 470                 475                 480 


Gly Tyr Ser Leu Leu Pro Leu Ala Pro Val Gly Gly Ile Ile Gly Trp 
                485                 490                 495     


Met Phe Ala Val Glu Gln Asp Gly Phe Lys Asn Gly Phe Ser Ile Thr 
            500                 505                 510         


Gly Gly Glu Phe Thr Arg Gln Ala Glu Val Thr Phe Val Gly His Pro 
        515                 520                 525             


Gly Asn Leu Val Ile Lys Gln Arg Phe Ser Gly Ile Asp Glu His Gly 
    530                 535                 540                 


His Leu Thr Ile Asp Thr Glu Leu Glu Gly Arg Val Pro Gln Ile Pro 
545                 550                 555                 560 


Phe Gly Ser Ser Val His Ile Glu Pro Tyr Thr Glu Leu Tyr His Tyr 
                565                 570                 575     


Ser Thr Ser Val Ile Thr Ser Ser Ser Thr Arg Glu Tyr Thr Val Thr 
            580                 585                 590         


Glu Pro Glu Arg Asp Gly Ala Ser Pro Ser Arg Ile Tyr Thr Tyr Gln 
        595                 600                 605             


Trp Arg Gln Thr Ile Thr Phe Gln Glu Cys Val His Asp Asp Ser Arg 
    610                 615                 620                 


Pro Ala Leu Pro Ser Thr Gln Gln Leu Ser Val Asp Ser Val Phe Val 
625                 630                 635                 640 


Leu Tyr Asn Gln Glu Glu Lys Ile Leu Arg Tyr Ala Leu Ser Asn Ser 
                645                 650                 655     


Ile Gly Pro Val Arg Glu Gly Ser Pro Asp Ala Leu Gln Asn Pro Cys 
            660                 665                 670         


Tyr Ile Gly Thr His Gly Cys Asp Thr Asn Ala Ala Cys Arg Pro Gly 
        675                 680                 685             


Pro Arg Thr Gln Phe Thr Cys Glu Cys Ser Ile Gly Phe Arg Gly Asp 
    690                 695                 700                 


Gly Arg Thr Cys Tyr Asp Ile Asp Glu Cys Ser Glu Gln Pro Ser Val 
705                 710                 715                 720 


Cys Gly Ser His Thr Ile Cys Asn Asn His Pro Gly Thr Phe Arg Cys 
                725                 730                 735     


Glu Cys Val Glu Gly Tyr Gln Phe Ser Asp Glu Gly Thr Cys Val Ala 
            740                 745                 750         


Val Val Asp Gln Arg Pro Ile Asn Tyr Cys Glu Thr Gly Leu His Asn 
        755                 760                 765             


Cys Asp Ile Pro Gln Arg Ala Gln Cys Ile Tyr Thr Gly Gly Ser Ser 
    770                 775                 780                 


Tyr Thr Cys Ser Cys Leu Pro Gly Phe Ser Gly Asp Gly Gln Ala Cys 
785                 790                 795                 800 


Gln Asp Val Asp Glu Cys Gln Pro Ser Arg Cys His Pro Asp Ala Phe 
                805                 810                 815     


Cys Tyr Asn Thr Pro Gly Ser Phe Thr Cys Gln Cys Lys Pro Gly Tyr 
            820                 825                 830         


Gln Gly Asp Gly Phe Arg Cys Val Pro Gly Glu Val Glu Lys Thr Arg 
        835                 840                 845             


Cys Gln His Glu Arg Glu His Ile Leu Gly Ala Ala Gly Ala Thr Asp 
    850                 855                 860                 


Pro Gln Arg Pro Ile Pro Pro Gly Leu Phe Val Pro Glu Cys Asp Ala 
865                 870                 875                 880 


His Gly His Tyr Ala Pro Thr Gln Cys His Gly Ser Thr Gly Tyr Cys 
                885                 890                 895     


Trp Cys Val Asp Arg Asp Gly Arg Glu Val Glu Gly Thr Arg Thr Arg 
            900                 905                 910         


Pro Gly Met Thr Pro Pro Cys Leu Ser Thr Val Ala Pro Pro Ile His 
        915                 920                 925             


Gln Gly Pro Ala Val Pro Thr Ala Val Ile Pro Leu Pro Pro Gly Thr 
    930                 935                 940                 


His Leu Leu Phe Ala Gln Thr Gly Lys Ile Glu Arg Leu Pro Leu Glu 
945                 950                 955                 960 


Gly Asn Thr Met Arg Lys Thr Glu Ala Lys Ala Phe Leu His Val Pro 
                965                 970                 975     


Ala Lys Val Ile Ile Gly Leu Ala Phe Asp Cys Val Asp Lys Met Val 
            980                 985                 990         


Tyr Trp Thr Asp Ile Thr Glu Pro  Ser Ile Gly Arg Ala  Ser Leu His 
        995                 1000                 1005             


Gly Gly  Glu Pro Thr Thr Ile  Ile Arg Gln Asp Leu  Gly Ser Pro 
    1010                 1015                 1020             


Glu Gly  Ile Ala Val Asp His  Leu Gly Arg Asn Ile  Phe Trp Thr 
    1025                 1030                 1035             


Asp Ser  Asn Leu Asp Arg Ile  Glu Val Ala Lys Leu  Asp Gly Thr 
    1040                 1045                 1050             


Gln Arg  Arg Val Leu Phe Glu  Thr Asp Leu Val Asn  Pro Arg Gly 
    1055                 1060                 1065             


Ile Val  Thr Asp Ser Val Arg  Gly Asn Leu Tyr Trp  Thr Asp Trp 
    1070                 1075                 1080             


Asn Arg  Asp Asn Pro Lys Ile  Glu Thr Ser Tyr Met  Asp Gly Thr 
    1085                 1090                 1095             


Asn Arg  Arg Ile Leu Val Gln  Asp Asp Leu Gly Leu  Pro Asn Gly 
    1100                 1105                 1110             


Leu Thr  Phe Asp Ala Phe Ser  Ser Gln Leu Cys Trp  Val Asp Ala 
    1115                 1120                 1125             


Gly Thr  Asn Arg Ala Glu Cys  Leu Asn Pro Ser Gln  Pro Ser Arg 
    1130                 1135                 1140             


Arg Lys  Ala Leu Glu Gly Leu  Gln Tyr Pro Phe Ala  Val Thr Ser 
    1145                 1150                 1155             


Tyr Gly  Lys Asn Leu Tyr Phe  Thr Asp Trp Lys Met  Asn Ser Val 
    1160                 1165                 1170             


Val Ala  Leu Asp Leu Ala Ile  Ser Lys Glu Thr Asp  Ala Phe Gln 
    1175                 1180                 1185             


Pro His  Lys Gln Thr Arg Leu  Tyr Gly Ile Thr Thr  Ala Leu Ser 
    1190                 1195                 1200             


Gln Cys  Pro Gln Gly His Asn  Tyr Cys Ser Val Asn  Asn Gly Gly 
    1205                 1210                 1215             


Cys Thr  His Leu Cys Leu Ala  Thr Pro Gly Ser Arg  Thr Cys Arg 
    1220                 1225                 1230             


Cys Pro  Asp Asn Thr Leu Gly  Val Asp Cys Ile Glu  Gln Lys 
    1235                 1240                 1245         


<210>  17
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210>  18
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Pro Ser Gly Pro Arg Gly Thr Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Arg Ala Val Leu Ala Val Pro Leu Glu Arg Gly 
            20                  25                  30          


Ala Pro Asn Lys Glu Glu Thr Pro Ala Thr Glu Ser Pro Asp Thr Gly 
        35                  40                  45              


Leu Tyr Tyr His Arg Tyr Leu Gln Glu Val Ile Asp Val Leu Glu Thr 
    50                  55                  60                  


Asp Gly His Phe Arg Glu Lys Leu Gln Ala Ala Asn Ala Glu Asp Ile 
65                  70                  75                  80  


Lys Ser Gly Lys Leu Ser Arg Glu Leu Asp Phe Val Ser His His Val 
                85                  90                  95      


Arg Thr Arg Leu Asp Glu Leu Lys Arg Gln Glu Val Ser Arg Leu Arg 
            100                 105                 110         


Met Leu Leu Lys Ala Lys Met Asp Ala Glu Gln Asp Pro Asn Val Gln 
        115                 120                 125             


Val Asp His Leu Asn Leu Leu Lys Gln Phe Glu His Leu Asp Pro Gln 
    130                 135                 140                 


Asn Gln His Thr Phe Glu Ala Arg Asp Leu Glu Leu Leu Ile Gln Thr 
145                 150                 155                 160 


Ala Thr Arg Asp Leu Ala Gln Tyr Asp Ala Ala His His Glu Glu Phe 
                165                 170                 175     


Lys Arg Tyr Glu Met Leu Lys Glu His Glu Arg Arg Arg Tyr Leu Glu 
            180                 185                 190         


Ser Leu Gly Glu Glu Gln Arg Lys Glu Ala Glu Arg Lys Leu Glu Glu 
        195                 200                 205             


Gln Gln Arg Arg His Arg Glu His Pro Lys Val Asn Val Pro Gly Ser 
    210                 215                 220                 


Gln Ala Gln Leu Lys Glu Val Trp Glu Glu Leu Asp Gly Leu Asp Pro 
225                 230                 235                 240 


Asn Arg Phe Asn Pro Lys Thr Phe Phe Ile Leu His Asp Ile Asn Ser 
                245                 250                 255     


Asp Gly Val Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys Glu 
            260                 265                 270         


Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Arg Glu 
        275                 280                 285             


Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Lys Asn Val 
    290                 295                 300                 


Asp Thr Asn Gln Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Ala Ser 
305                 310                 315                 320 


Thr Gln Arg Lys Glu Phe Gly Asp Thr Gly Glu Gly Trp Glu Thr Val 
                325                 330                 335     


Glu Met His Pro Ala Tyr Thr Glu Glu Glu Leu Arg Arg Phe Glu Glu 
            340                 345                 350         


Glu Leu Ala Ala Arg Glu Ala Glu Leu Asn Ala Lys Ala Gln Arg Leu 
        355                 360                 365             


Ser Gln Glu Thr Glu Ala Leu Gly Arg Ser Gln Gly Arg Leu Glu Ala 
    370                 375                 380                 


Gln Lys Arg Glu Leu Gln Gln Ala Val Leu His Met Glu Gln Arg Lys 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gly His Lys Ala Pro Ala Ala His Pro 
                405                 410                 415     


Glu Gly Gln Leu Lys Phe His Pro Asp Thr Asp Asp Val Pro Val Pro 
            420                 425                 430         


Ala Pro Ala Gly Asp Gln Lys Glu Val Asp Thr Ser Glu Lys Lys Leu 
        435                 440                 445             


Leu Glu Arg Leu Pro Glu Val Glu Val Pro Gln His Leu 
    450                 455                 460     


<210>  19
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Ser Arg Ile Ala Arg Ala Leu Ala Leu Val Val Thr Leu Leu 
1               5                   10                  15      


His Leu Thr Arg Leu Ala Leu Ser Thr Cys Pro Ala Ala Cys His Cys 
            20                  25                  30          


Pro Leu Glu Ala Pro Lys Cys Ala Pro Gly Val Gly Leu Val Arg Asp 
        35                  40                  45              


Gly Cys Gly Cys Cys Lys Val Cys Ala Lys Gln Leu Asn Glu Asp Cys 
    50                  55                  60                  


Ser Lys Thr Gln Pro Cys Asp His Thr Lys Gly Leu Glu Cys Asn Phe 
65                  70                  75                  80  


Gly Ala Ser Ser Thr Ala Leu Lys Gly Ile Cys Arg Ala Gln Ser Glu 
                85                  90                  95      


Gly Arg Pro Cys Glu Tyr Asn Ser Arg Ile Tyr Gln Asn Gly Glu Ser 
            100                 105                 110         


Phe Gln Pro Ser Cys Lys His Gln Cys Thr Cys Ile Asp Gly Ala Val 
        115                 120                 125             


Gly Cys Ile Pro Leu Cys Pro Gln Glu Leu Ser Leu Pro Asn Leu Gly 
    130                 135                 140                 


Cys Pro Asn Pro Arg Leu Val Lys Val Thr Gly Gln Cys Cys Glu Glu 
145                 150                 155                 160 


Trp Val Cys Asp Glu Asp Ser Ile Lys Asp Pro Met Glu Asp Gln Asp 
                165                 170                 175     


Gly Leu Leu Gly Lys Glu Leu Gly Phe Asp Ala Ser Glu Val Glu Leu 
            180                 185                 190         


Thr Arg Asn Asn Glu Leu Ile Ala Val Gly Lys Gly Ser Ser Leu Lys 
        195                 200                 205             


Arg Leu Pro Val Phe Gly Met Glu Pro Arg Ile Leu Tyr Asn Pro Leu 
    210                 215                 220                 


Gln Gly Gln Lys Cys Ile Val Gln Thr Thr Ser Trp Ser Gln Cys Ser 
225                 230                 235                 240 


Lys Thr Cys Gly Thr Gly Ile Ser Thr Arg Val Thr Asn Asp Asn Pro 
                245                 250                 255     


Glu Cys Arg Leu Val Lys Glu Thr Arg Ile Cys Glu Val Arg Pro Cys 
            260                 265                 270         


Gly Gln Pro Val Tyr Ser Ser Leu Lys Lys Gly Lys Lys Cys Ser Lys 
        275                 280                 285             


Thr Lys Lys Ser Pro Glu Pro Val Arg Phe Thr Tyr Ala Gly Cys Leu 
    290                 295                 300                 


Ser Val Lys Lys Tyr Arg Pro Lys Tyr Cys Gly Ser Arg Val Asp Gly 
305                 310                 315                 320 


Arg Cys Cys Thr Pro Gln Leu Thr Arg Thr Val Lys Met Arg Phe Arg 
                325                 330                 335     


Cys Glu Asp Gly Glu Thr Phe Ser Lys Asn Val Met Met Ile Gln Ser 
            340                 345                 350         


Cys Lys Cys Asn Tyr Asn Cys Pro His Ala Asn Glu Ala Ala Phe Pro 
        355                 360                 365             


Phe Tyr Arg Leu Phe Asn Asp Ile His Lys Phe Arg Gly 
    370                 375                 380     


<210>  20
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  21
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Arg Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  22
<211>  895
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Arg Met Ser Val Gly Leu Ser Leu Leu Leu Pro Leu Trp Gly Arg 
1               5                   10                  15      


Thr Phe Leu Leu Leu Leu Ser Val Val Met Ala Gln Ser His Trp Pro 
            20                  25                  30          


Ser Glu Pro Ser Glu Ala Val Arg Asp Trp Glu Asn Gln Leu Glu Ala 
        35                  40                  45              


Ser Met His Ser Val Leu Ser Asp Leu His Glu Ala Val Pro Thr Val 
    50                  55                  60                  


Val Gly Ile Pro Asp Gly Thr Ala Val Val Gly Arg Ser Phe Arg Val 
65                  70                  75                  80  


Thr Ile Pro Thr Asp Leu Ile Ala Ser Ser Gly Asp Ile Ile Lys Val 
                85                  90                  95      


Ser Ala Ala Gly Lys Glu Ala Leu Pro Ser Trp Leu His Trp Asp Ser 
            100                 105                 110         


Gln Ser His Thr Leu Glu Gly Leu Pro Leu Asp Thr Asp Lys Gly Val 
        115                 120                 125             


His Tyr Ile Ser Val Ser Ala Thr Arg Leu Gly Ala Asn Gly Ser His 
    130                 135                 140                 


Ile Pro Gln Thr Ser Ser Val Phe Ser Ile Glu Val Tyr Pro Glu Asp 
145                 150                 155                 160 


His Ser Glu Leu Gln Ser Val Arg Thr Ala Ser Pro Asp Pro Gly Glu 
                165                 170                 175     


Val Val Ser Ser Ala Cys Ala Ala Asp Glu Pro Val Thr Val Leu Thr 
            180                 185                 190         


Val Ile Leu Asp Ala Asp Leu Thr Lys Met Thr Pro Lys Gln Arg Ile 
        195                 200                 205             


Asp Leu Leu His Arg Met Arg Ser Phe Ser Glu Val Glu Leu His Asn 
    210                 215                 220                 


Met Lys Leu Val Pro Val Val Asn Asn Arg Leu Phe Asp Met Ser Ala 
225                 230                 235                 240 


Phe Met Ala Gly Pro Gly Asn Ala Lys Lys Val Val Glu Asn Gly Ala 
                245                 250                 255     


Leu Leu Ser Trp Lys Leu Gly Cys Ser Leu Asn Gln Asn Ser Val Pro 
            260                 265                 270         


Asp Ile His Gly Val Glu Ala Pro Ala Arg Glu Gly Ala Met Ser Ala 
        275                 280                 285             


Gln Leu Gly Tyr Pro Val Val Gly Trp His Ile Ala Asn Lys Lys Pro 
    290                 295                 300                 


Pro Leu Pro Lys Arg Val Arg Arg Gln Ile His Ala Thr Pro Thr Pro 
305                 310                 315                 320 


Val Thr Ala Ile Gly Pro Pro Thr Thr Ala Ile Gln Glu Pro Pro Ser 
                325                 330                 335     


Arg Ile Val Pro Thr Pro Thr Ser Pro Ala Ile Ala Pro Pro Thr Glu 
            340                 345                 350         


Thr Met Ala Pro Pro Val Arg Asp Pro Val Pro Gly Lys Pro Thr Val 
        355                 360                 365             


Thr Ile Arg Thr Arg Gly Ala Ile Ile Gln Thr Pro Thr Leu Gly Pro 
    370                 375                 380                 


Ile Gln Pro Thr Arg Val Ser Glu Ala Gly Thr Thr Val Pro Gly Gln 
385                 390                 395                 400 


Ile Arg Pro Thr Met Thr Ile Pro Gly Tyr Val Glu Pro Thr Ala Val 
                405                 410                 415     


Ala Thr Pro Pro Thr Thr Thr Thr Lys Lys Pro Arg Val Ser Thr Pro 
            420                 425                 430         


Lys Pro Ala Thr Pro Ser Thr Asp Ser Thr Thr Thr Thr Thr Arg Arg 
        435                 440                 445             


Pro Thr Lys Lys Pro Arg Thr Pro Arg Pro Val Pro Arg Val Thr Thr 
    450                 455                 460                 


Lys Val Ser Ile Thr Arg Leu Glu Thr Ala Ser Pro Pro Thr Arg Ile 
465                 470                 475                 480 


Arg Thr Thr Thr Ser Gly Val Pro Arg Gly Gly Glu Pro Asn Gln Arg 
                485                 490                 495     


Pro Glu Leu Lys Asn His Ile Asp Arg Val Asp Ala Trp Val Gly Thr 
            500                 505                 510         


Tyr Phe Glu Val Lys Ile Pro Ser Asp Thr Phe Tyr Asp His Glu Asp 
        515                 520                 525             


Thr Thr Thr Asp Lys Leu Lys Leu Thr Leu Lys Leu Arg Glu Gln Gln 
    530                 535                 540                 


Leu Val Gly Glu Lys Ser Trp Val Gln Phe Asn Ser Asn Ser Gln Leu 
545                 550                 555                 560 


Met Tyr Gly Leu Pro Asp Ser Ser His Val Gly Lys His Glu Tyr Phe 
                565                 570                 575     


Met His Ala Thr Asp Lys Gly Gly Leu Ser Ala Val Asp Ala Phe Glu 
            580                 585                 590         


Ile His Val His Arg Arg Pro Gln Gly Asp Arg Ala Pro Ala Arg Phe 
        595                 600                 605             


Lys Ala Lys Phe Val Gly Asp Pro Ala Leu Val Leu Asn Asp Ile His 
    610                 615                 620                 


Lys Lys Ile Ala Leu Val Lys Lys Leu Ala Phe Ala Phe Gly Asp Arg 
625                 630                 635                 640 


Asn Cys Ser Thr Ile Thr Leu Gln Asn Ile Thr Arg Gly Ser Ile Val 
                645                 650                 655     


Val Glu Trp Thr Asn Asn Thr Leu Pro Leu Glu Pro Cys Pro Lys Glu 
            660                 665                 670         


Gln Ile Ala Gly Leu Ser Arg Arg Ile Ala Glu Asp Asp Gly Lys Pro 
        675                 680                 685             


Arg Pro Ala Phe Ser Asn Ala Leu Glu Pro Asp Phe Lys Ala Thr Ser 
    690                 695                 700                 


Ile Thr Val Thr Gly Ser Gly Ser Cys Arg His Leu Gln Phe Ile Pro 
705                 710                 715                 720 


Val Val Pro Pro Arg Arg Val Pro Ser Glu Ala Pro Pro Thr Glu Val 
                725                 730                 735     


Pro Asp Arg Asp Pro Glu Lys Ser Ser Glu Asp Asp Val Tyr Leu His 
            740                 745                 750         


Thr Val Ile Pro Ala Val Val Val Ala Ala Ile Leu Leu Ile Ala Gly 
        755                 760                 765             


Ile Ile Ala Met Ile Cys Tyr Arg Lys Lys Arg Lys Gly Lys Leu Thr 
    770                 775                 780                 


Leu Glu Asp Gln Ala Thr Phe Ile Lys Lys Gly Val Pro Ile Ile Phe 
785                 790                 795                 800 


Ala Asp Glu Leu Asp Asp Ser Lys Pro Pro Pro Ser Ser Ser Met Pro 
                805                 810                 815     


Leu Ile Leu Gln Glu Glu Lys Ala Pro Leu Pro Pro Pro Glu Tyr Pro 
            820                 825                 830         


Asn Gln Ser Val Pro Glu Thr Thr Pro Leu Asn Gln Asp Thr Met Gly 
        835                 840                 845             


Glu Tyr Thr Pro Leu Arg Asp Glu Asp Pro Asn Ala Pro Pro Tyr Gln 
    850                 855                 860                 


Pro Pro Pro Pro Phe Thr Ala Pro Met Glu Gly Lys Gly Ser Arg Pro 
865                 870                 875                 880 


Lys Asn Met Thr Pro Tyr Arg Ser Pro Pro Pro Tyr Val Pro Pro 
                885                 890                 895 


<210>  23
<211>  1479
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Lys Arg Ser Arg Gly Pro Gly Arg Arg Cys Leu Leu Ala Leu 
1               5                   10                  15      


Val Leu Phe Cys Ala Trp Gly Thr Leu Ala Val Val Ala Gln Lys Pro 
            20                  25                  30          


Gly Ala Gly Cys Pro Ser Arg Cys Leu Cys Phe Arg Thr Thr Val Arg 
        35                  40                  45              


Cys Met His Leu Leu Leu Glu Ala Val Pro Ala Val Ala Pro Gln Thr 
    50                  55                  60                  


Ser Ile Leu Asp Leu Arg Phe Asn Arg Ile Arg Glu Ile Gln Pro Gly 
65                  70                  75                  80  


Ala Phe Arg Arg Leu Arg Asn Leu Asn Thr Leu Leu Leu Asn Asn Asn 
                85                  90                  95      


Gln Ile Lys Arg Ile Pro Ser Gly Ala Phe Glu Asp Leu Glu Asn Leu 
            100                 105                 110         


Lys Tyr Leu Tyr Leu Tyr Lys Asn Glu Ile Gln Ser Ile Asp Arg Gln 
        115                 120                 125             


Ala Phe Lys Gly Leu Ala Ser Leu Glu Gln Leu Tyr Leu His Phe Asn 
    130                 135                 140                 


Gln Ile Glu Thr Leu Asp Pro Asp Ser Phe Gln His Leu Pro Lys Leu 
145                 150                 155                 160 


Glu Arg Leu Phe Leu His Asn Asn Arg Ile Thr His Leu Val Pro Gly 
                165                 170                 175     


Thr Phe Asn His Leu Glu Ser Met Lys Arg Leu Arg Leu Asp Ser Asn 
            180                 185                 190         


Thr Leu His Cys Asp Cys Glu Ile Leu Trp Leu Ala Asp Leu Leu Lys 
        195                 200                 205             


Thr Tyr Ala Glu Ser Gly Asn Ala Gln Ala Ala Ala Ile Cys Glu Tyr 
    210                 215                 220                 


Pro Arg Arg Ile Gln Gly Arg Ser Val Ala Thr Ile Thr Pro Glu Glu 
225                 230                 235                 240 


Leu Asn Cys Glu Arg Pro Arg Ile Thr Ser Glu Pro Gln Asp Ala Asp 
                245                 250                 255     


Val Thr Ser Gly Asn Thr Val Tyr Phe Thr Cys Arg Ala Glu Gly Asn 
            260                 265                 270         


Pro Lys Pro Glu Ile Ile Trp Leu Arg Asn Asn Asn Glu Leu Ser Met 
        275                 280                 285             


Lys Thr Asp Ser Arg Leu Asn Leu Leu Asp Asp Gly Thr Leu Met Ile 
    290                 295                 300                 


Gln Asn Thr Gln Glu Thr Asp Gln Gly Ile Tyr Gln Cys Met Ala Lys 
305                 310                 315                 320 


Asn Val Ala Gly Glu Val Lys Thr Gln Glu Val Thr Leu Arg Tyr Phe 
                325                 330                 335     


Gly Ser Pro Ala Arg Pro Thr Phe Val Ile Gln Pro Gln Asn Thr Glu 
            340                 345                 350         


Val Leu Val Gly Glu Ser Val Thr Leu Glu Cys Ser Ala Thr Gly His 
        355                 360                 365             


Pro Pro Pro Arg Ile Ser Trp Thr Arg Gly Asp Arg Thr Pro Leu Pro 
    370                 375                 380                 


Val Asp Pro Arg Val Asn Ile Thr Pro Ser Gly Gly Leu Tyr Ile Gln 
385                 390                 395                 400 


Asn Val Val Gln Gly Asp Ser Gly Glu Tyr Ala Cys Ser Ala Thr Asn 
                405                 410                 415     


Asn Ile Asp Ser Val His Ala Thr Ala Phe Ile Ile Val Gln Ala Leu 
            420                 425                 430         


Pro Gln Phe Thr Val Thr Pro Gln Asp Arg Val Val Ile Glu Gly Gln 
        435                 440                 445             


Thr Val Asp Phe Gln Cys Glu Ala Lys Gly Asn Pro Pro Pro Val Ile 
    450                 455                 460                 


Ala Trp Thr Lys Gly Gly Ser Gln Leu Ser Val Asp Arg Arg His Leu 
465                 470                 475                 480 


Val Leu Ser Ser Gly Thr Leu Arg Ile Ser Gly Val Ala Leu His Asp 
                485                 490                 495     


Gln Gly Gln Tyr Glu Cys Gln Ala Val Asn Ile Ile Gly Ser Gln Lys 
            500                 505                 510         


Val Val Ala His Leu Thr Val Gln Pro Arg Val Thr Pro Val Phe Ala 
        515                 520                 525             


Ser Ile Pro Ser Asp Thr Thr Val Glu Val Gly Ala Asn Val Gln Leu 
    530                 535                 540                 


Pro Cys Ser Ser Gln Gly Glu Pro Glu Pro Ala Ile Thr Trp Asn Lys 
545                 550                 555                 560 


Asp Gly Val Gln Val Thr Glu Ser Gly Lys Phe His Ile Ser Pro Glu 
                565                 570                 575     


Gly Phe Leu Thr Ile Asn Asp Val Gly Pro Ala Asp Ala Gly Arg Tyr 
            580                 585                 590         


Glu Cys Val Ala Arg Asn Thr Ile Gly Ser Ala Ser Val Ser Met Val 
        595                 600                 605             


Leu Ser Val Asn Val Pro Asp Val Ser Arg Asn Gly Asp Pro Phe Val 
    610                 615                 620                 


Ala Thr Ser Ile Val Glu Ala Ile Ala Thr Val Asp Arg Ala Ile Asn 
625                 630                 635                 640 


Ser Thr Arg Thr His Leu Phe Asp Ser Arg Pro Arg Ser Pro Asn Asp 
                645                 650                 655     


Leu Leu Ala Leu Phe Arg Tyr Pro Arg Asp Pro Tyr Thr Val Glu Gln 
            660                 665                 670         


Ala Arg Ala Gly Glu Ile Phe Glu Arg Thr Leu Gln Leu Ile Gln Glu 
        675                 680                 685             


His Val Gln His Gly Leu Met Val Asp Leu Asn Gly Thr Ser Tyr His 
    690                 695                 700                 


Tyr Asn Asp Leu Val Ser Pro Gln Tyr Leu Asn Leu Ile Ala Asn Leu 
705                 710                 715                 720 


Ser Gly Cys Thr Ala His Arg Arg Val Asn Asn Cys Ser Asp Met Cys 
                725                 730                 735     


Phe His Gln Lys Tyr Arg Thr His Asp Gly Thr Cys Asn Asn Leu Gln 
            740                 745                 750         


His Pro Met Trp Gly Ala Ser Leu Thr Ala Phe Glu Arg Leu Leu Lys 
        755                 760                 765             


Ser Val Tyr Glu Asn Gly Phe Asn Thr Pro Arg Gly Ile Asn Pro His 
    770                 775                 780                 


Arg Leu Tyr Asn Gly His Ala Leu Pro Met Pro Arg Leu Val Ser Thr 
785                 790                 795                 800 


Thr Leu Ile Gly Thr Glu Thr Val Thr Pro Asp Glu Gln Phe Thr His 
                805                 810                 815     


Met Leu Met Gln Trp Gly Gln Phe Leu Asp His Asp Leu Asp Ser Thr 
            820                 825                 830         


Val Val Ala Leu Ser Gln Ala Arg Phe Ser Asp Gly Gln His Cys Ser 
        835                 840                 845             


Asn Val Cys Ser Asn Asp Pro Pro Cys Phe Ser Val Met Ile Pro Pro 
    850                 855                 860                 


Asn Asp Ser Arg Ala Arg Ser Gly Ala Arg Cys Met Phe Phe Val Arg 
865                 870                 875                 880 


Ser Ser Pro Val Cys Gly Ser Gly Met Thr Ser Leu Leu Met Asn Ser 
                885                 890                 895     


Val Tyr Pro Arg Glu Gln Ile Asn Gln Leu Thr Ser Tyr Ile Asp Ala 
            900                 905                 910         


Ser Asn Val Tyr Gly Ser Thr Glu His Glu Ala Arg Ser Ile Arg Asp 
        915                 920                 925             


Leu Ala Ser His Arg Gly Leu Leu Arg Gln Gly Ile Val Gln Arg Ser 
    930                 935                 940                 


Gly Lys Pro Leu Leu Pro Phe Ala Thr Gly Pro Pro Thr Glu Cys Met 
945                 950                 955                 960 


Arg Asp Glu Asn Glu Ser Pro Ile Pro Cys Phe Leu Ala Gly Asp His 
                965                 970                 975     


Arg Ala Asn Glu Gln Leu Gly Leu Thr Ser Met His Thr Leu Trp Phe 
            980                 985                 990         


Arg Glu His Asn Arg Ile Ala Thr  Glu Leu Leu Lys Leu  Asn Pro His 
        995                 1000                 1005             


Trp Asp  Gly Asp Thr Ile Tyr  Tyr Glu Thr Arg Lys  Ile Val Gly 
    1010                 1015                 1020             


Ala Glu  Ile Gln His Ile Thr  Tyr Gln His Trp Leu  Pro Lys Ile 
    1025                 1030                 1035             


Leu Gly  Glu Val Gly Met Arg  Thr Leu Gly Glu Tyr  His Gly Tyr 
    1040                 1045                 1050             


Asp Pro  Gly Ile Asn Ala Gly  Ile Phe Asn Ala Phe  Ala Thr Ala 
    1055                 1060                 1065             


Ala Phe  Arg Phe Gly His Thr  Leu Val Asn Pro Leu  Leu Tyr Arg 
    1070                 1075                 1080             


Leu Asp  Glu Asn Phe Gln Pro  Ile Ala Gln Asp His  Leu Pro Leu 
    1085                 1090                 1095             


His Lys  Ala Phe Phe Ser Pro  Phe Arg Ile Val Asn  Glu Gly Gly 
    1100                 1105                 1110             


Ile Asp  Pro Leu Leu Arg Gly  Leu Phe Gly Val Ala  Gly Lys Met 
    1115                 1120                 1125             


Arg Val  Pro Ser Gln Leu Leu  Asn Thr Glu Leu Thr  Glu Arg Leu 
    1130                 1135                 1140             


Phe Ser  Met Ala His Thr Val  Ala Leu Asp Leu Ala  Ala Ile Asn 
    1145                 1150                 1155             


Ile Gln  Arg Gly Arg Asp His  Gly Ile Pro Pro Tyr  His Asp Tyr 
    1160                 1165                 1170             


Arg Val  Tyr Cys Asn Leu Ser  Ala Ala His Thr Phe  Glu Asp Leu 
    1175                 1180                 1185             


Lys Asn  Glu Ile Lys Asn Pro  Glu Ile Arg Glu Lys  Leu Lys Arg 
    1190                 1195                 1200             


Leu Tyr  Gly Ser Thr Leu Asn  Ile Asp Leu Phe Pro  Ala Leu Val 
    1205                 1210                 1215             


Val Glu  Asp Leu Val Pro Gly  Ser Arg Leu Gly Pro  Thr Leu Met 
    1220                 1225                 1230             


Cys Leu  Leu Ser Thr Gln Phe  Lys Arg Leu Arg Asp  Gly Asp Arg 
    1235                 1240                 1245             


Leu Trp  Tyr Glu Asn Pro Gly  Val Phe Ser Pro Ala  Gln Leu Thr 
    1250                 1255                 1260             


Gln Ile  Lys Gln Thr Ser Leu  Ala Arg Ile Leu Cys  Asp Asn Ala 
    1265                 1270                 1275             


Asp Asn  Ile Thr Arg Val Gln  Ser Asp Val Phe Arg  Val Ala Glu 
    1280                 1285                 1290             


Phe Pro  His Gly Tyr Gly Ser  Cys Asp Glu Ile Pro  Arg Val Asp 
    1295                 1300                 1305             


Leu Arg  Val Trp Gln Asp Cys  Cys Glu Asp Cys Arg  Thr Arg Gly 
    1310                 1315                 1320             


Gln Phe  Asn Ala Phe Ser Tyr  His Phe Arg Gly Arg  Arg Ser Leu 
    1325                 1330                 1335             


Glu Phe  Ser Tyr Gln Glu Asp  Lys Pro Thr Lys Lys  Thr Arg Pro 
    1340                 1345                 1350             


Arg Lys  Ile Pro Ser Val Gly  Arg Gln Gly Glu His  Leu Ser Asn 
    1355                 1360                 1365             


Ser Thr  Ser Ala Phe Ser Thr  Arg Ser Asp Ala Ser  Gly Thr Asn 
    1370                 1375                 1380             


Asp Phe  Arg Glu Phe Val Leu  Glu Met Gln Lys Thr  Ile Thr Asp 
    1385                 1390                 1395             


Leu Arg  Thr Gln Ile Lys Lys  Leu Glu Ser Arg Leu  Ser Thr Thr 
    1400                 1405                 1410             


Glu Cys  Val Asp Ala Gly Gly  Glu Ser His Ala Asn  Asn Thr Lys 
    1415                 1420                 1425             


Trp Lys  Lys Asp Ala Cys Thr  Ile Cys Glu Cys Lys  Asp Gly Gln 
    1430                 1435                 1440             


Val Thr  Cys Phe Val Glu Ala  Cys Pro Pro Ala Thr  Cys Ala Val 
    1445                 1450                 1455             


Pro Val  Asn Ile Pro Gly Ala  Cys Cys Pro Val Cys  Leu Gln Lys 
    1460                 1465                 1470             


Arg Ala  Glu Glu Lys Pro 
    1475                 


<210>  24
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  25
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Arg Ala Leu Leu Ala Arg Leu Leu Leu Cys Val Leu Val Val Ser 
1               5                   10                  15      


Asp Ser Lys Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 
            20                  25                  30          


Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 
        35                  40                  45              


His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 
    50                  55                  60                  


Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 
                85                  90                  95      


Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 
            100                 105                 110         


Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 
        115                 120                 125             


Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 
    130                 135                 140                 


Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
                165                 170                 175     


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
            180                 185                 190         


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
        195                 200                 205             


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
    210                 215                 220                 


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
225                 230                 235                 240 


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
                245                 250                 255     


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
            260                 265                 270         


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
        275                 280                 285             


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
    290                 295                 300                 


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
305                 310                 315                 320 


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
                325                 330                 335     


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
            340                 345                 350         


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
        355                 360                 365             


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
    370                 375                 380                 


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
385                 390                 395                 400 


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
                405                 410                 415     


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            420                 425                 430     


<210>  26
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Thr Ala Lys 
145                 


<210>  27
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  28
<211>  2444
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Pro Arg Arg Leu Cys Cys Thr Gly Gly Gly Glu Gly Thr Pro Gly 
1               5                   10                  15      


Ala Ser Gly Lys Arg Gly Pro Ala Ala Thr Thr Ser Leu Val Leu Cys 
            20                  25                  30          


Ile Pro Ser Val Pro Pro Pro Val Pro Phe Pro Thr Leu Trp Pro Pro 
        35                  40                  45              


Pro Ser Trp Arg Arg Gln Pro Pro Gly Gly Ile Arg Arg Asp Phe Ser 
    50                  55                  60                  


Arg Arg Leu Arg Arg Glu Ala Asn Leu Val Ala Thr Cys Leu Pro Val 
65                  70                  75                  80  


Arg Ala Ser Leu Pro His Arg Leu Asn Met Leu Arg Gly Pro Gly Pro 
                85                  90                  95      


Gly Leu Leu Leu Leu Ala Val Leu Cys Leu Gly Thr Ala Val Pro Ser 
            100                 105                 110         


Thr Gly Ala Ser Lys Ser Lys Arg Gln Ala Gln Gln Met Val Gln Pro 
        115                 120                 125             


Gln Ser Pro Val Ala Val Ser Gln Ser Lys Pro Gly Cys Tyr Asp Asn 
    130                 135                 140                 


Gly Lys His Tyr Gln Ile Asn Gln Gln Trp Glu Arg Thr Tyr Leu Gly 
145                 150                 155                 160 


Asn Ala Leu Val Cys Thr Cys Tyr Gly Gly Ser Arg Gly Phe Asn Cys 
                165                 170                 175     


Glu Ser Lys Pro Glu Ala Glu Glu Thr Cys Phe Asp Lys Tyr Thr Gly 
            180                 185                 190         


Asn Thr Tyr Arg Val Gly Asp Thr Tyr Glu Arg Pro Lys Asp Ser Met 
        195                 200                 205             


Ile Trp Asp Cys Thr Cys Ile Gly Ala Gly Arg Gly Arg Ile Ser Cys 
    210                 215                 220                 


Thr Ile Ala Asn Arg Cys His Glu Gly Gly Gln Ser Tyr Lys Ile Gly 
225                 230                 235                 240 


Asp Thr Trp Arg Arg Pro His Glu Thr Gly Gly Tyr Met Leu Glu Cys 
                245                 250                 255     


Val Cys Leu Gly Asn Gly Lys Gly Glu Trp Thr Cys Lys Pro Ile Ala 
            260                 265                 270         


Glu Lys Cys Phe Asp His Ala Ala Gly Thr Ser Tyr Val Val Gly Glu 
        275                 280                 285             


Thr Trp Glu Lys Pro Tyr Gln Gly Trp Met Met Val Asp Cys Thr Cys 
    290                 295                 300                 


Leu Gly Glu Gly Ser Gly Arg Ile Thr Cys Thr Ser Arg Asn Arg Cys 
305                 310                 315                 320 


Asn Asp Gln Asp Thr Arg Thr Ser Tyr Arg Ile Gly Asp Thr Trp Ser 
                325                 330                 335     


Lys Lys Asp Asn Arg Gly Asn Leu Leu Gln Cys Ile Cys Thr Gly Asn 
            340                 345                 350         


Gly Arg Gly Glu Trp Lys Cys Glu Arg His Thr Ser Val Gln Thr Thr 
        355                 360                 365             


Ser Ser Gly Ser Gly Pro Phe Thr Asp Ala Arg Ala Ala Val Tyr Gln 
    370                 375                 380                 


Pro Gln Pro His Pro Gln Pro Pro Pro Tyr Gly His Cys Val Thr Asp 
385                 390                 395                 400 


Ser Gly Val Val Tyr Ser Val Gly Met Gln Trp Leu Lys Thr Gln Gly 
                405                 410                 415     


Asn Lys Gln Met Leu Cys Thr Cys Leu Gly Asn Gly Val Ser Cys Gln 
            420                 425                 430         


Glu Thr Ala Val Thr Gln Thr Tyr Gly Gly Asn Ser Asn Gly Glu Pro 
        435                 440                 445             


Cys Val Leu Pro Phe Thr Tyr Asn Gly Arg Thr Phe Tyr Ser Cys Thr 
    450                 455                 460                 


Thr Glu Gly Arg Gln Asp Gly His Leu Trp Cys Ser Thr Thr Ser Asn 
465                 470                 475                 480 


Tyr Glu Gln Asp Gln Lys Tyr Ser Phe Cys Thr Asp His Thr Val Leu 
                485                 490                 495     


Val Gln Thr Arg Gly Gly Asn Ser Asn Gly Ala Leu Cys His Phe Pro 
            500                 505                 510         


Phe Leu Tyr Asn Asn His Asn Tyr Thr Asp Cys Thr Ser Glu Gly Arg 
        515                 520                 525             


Arg Asp Asn Met Lys Trp Cys Gly Thr Thr Gln Asn Tyr Asp Ala Asp 
    530                 535                 540                 


Gln Lys Phe Gly Phe Cys Pro Met Ala Ala His Glu Glu Ile Cys Thr 
545                 550                 555                 560 


Thr Asn Glu Gly Val Met Tyr Arg Ile Gly Asp Gln Trp Asp Lys Gln 
                565                 570                 575     


His Asp Met Gly His Met Met Arg Cys Thr Cys Val Gly Asn Gly Arg 
            580                 585                 590         


Gly Glu Trp Thr Cys Ile Ala Tyr Ser Gln Leu Arg Asp Gln Cys Ile 
        595                 600                 605             


Val Asp Asp Ile Thr Tyr Asn Val Asn Asp Thr Phe His Lys Arg His 
    610                 615                 620                 


Glu Glu Gly His Met Leu Asn Cys Thr Cys Phe Gly Gln Gly Arg Gly 
625                 630                 635                 640 


Arg Trp Lys Cys Asp Pro Val Asp Gln Cys Gln Asp Ser Glu Thr Gly 
                645                 650                 655     


Thr Phe Tyr Gln Ile Gly Asp Ser Trp Glu Lys Tyr Val His Gly Val 
            660                 665                 670         


Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg Gly Ile Gly Glu Trp His Cys 
        675                 680                 685             


Gln Pro Leu Gln Thr Tyr Pro Ser Ser Ser Gly Pro Val Glu Val Phe 
    690                 695                 700                 


Ile Thr Glu Thr Pro Ser Gln Pro Asn Ser His Pro Ile Gln Trp Asn 
705                 710                 715                 720 


Ala Pro Gln Pro Ser His Ile Ser Lys Tyr Ile Leu Arg Trp Arg Pro 
                725                 730                 735     


Lys Asn Ser Val Gly Arg Trp Lys Glu Ala Thr Ile Pro Gly His Leu 
            740                 745                 750         


Asn Ser Tyr Thr Ile Lys Gly Leu Lys Pro Gly Val Val Tyr Glu Gly 
        755                 760                 765             


Gln Leu Ile Ser Ile Gln Gln Tyr Gly His Gln Glu Val Thr Arg Phe 
    770                 775                 780                 


Asp Phe Thr Thr Thr Ser Thr Ser Thr Pro Val Thr Ser Asn Thr Val 
785                 790                 795                 800 


Thr Gly Glu Thr Thr Pro Phe Ser Pro Leu Val Ala Thr Ser Glu Ser 
                805                 810                 815     


Val Thr Glu Ile Thr Ala Ser Ser Phe Val Val Ser Trp Val Ser Ala 
            820                 825                 830         


Ser Asp Thr Val Ser Gly Phe Arg Val Glu Tyr Glu Leu Ser Glu Glu 
        835                 840                 845             


Gly Asp Glu Pro Gln Tyr Leu Asp Leu Pro Ser Thr Ala Thr Ser Val 
    850                 855                 860                 


Asn Ile Pro Asp Leu Leu Pro Gly Arg Lys Tyr Ile Val Asn Val Tyr 
865                 870                 875                 880 


Gln Ile Ser Glu Asp Gly Glu Gln Ser Leu Ile Leu Ser Thr Ser Gln 
                885                 890                 895     


Thr Thr Ala Pro Asp Ala Pro Pro Asp Pro Thr Val Asp Gln Val Asp 
            900                 905                 910         


Asp Thr Ser Ile Val Val Arg Trp Ser Arg Pro Gln Ala Pro Ile Thr 
        915                 920                 925             


Gly Tyr Arg Ile Val Tyr Ser Pro Ser Val Glu Gly Ser Ser Thr Glu 
    930                 935                 940                 


Leu Asn Leu Pro Glu Thr Ala Asn Ser Val Thr Leu Ser Asp Leu Gln 
945                 950                 955                 960 


Pro Gly Val Gln Tyr Asn Ile Thr Ile Tyr Ala Val Glu Glu Asn Gln 
                965                 970                 975     


Glu Ser Thr Pro Val Val Ile Gln Gln Glu Thr Thr Gly Thr Pro Arg 
            980                 985                 990         


Ser Asp Thr Val Pro Ser Pro Arg  Asp Leu Gln Phe Val  Glu Val Thr 
        995                 1000                 1005             


Asp Val  Lys Val Thr Ile Met  Trp Thr Pro Pro Glu  Ser Ala Val 
    1010                 1015                 1020             


Thr Gly  Tyr Arg Val Asp Val  Ile Pro Val Asn Leu  Pro Gly Glu 
    1025                 1030                 1035             


His Gly  Gln Arg Leu Pro Ile  Ser Arg Asn Thr Phe  Ala Glu Val 
    1040                 1045                 1050             


Thr Gly  Leu Ser Pro Gly Val  Thr Tyr Tyr Phe Lys  Val Phe Ala 
    1055                 1060                 1065             


Val Ser  His Gly Arg Glu Ser  Lys Pro Leu Thr Ala  Gln Gln Thr 
    1070                 1075                 1080             


Thr Lys  Leu Asp Ala Pro Thr  Asn Leu Gln Phe Val  Asn Glu Thr 
    1085                 1090                 1095             


Asp Ser  Thr Val Leu Val Arg  Trp Thr Pro Pro Arg  Ala Gln Ile 
    1100                 1105                 1110             


Thr Gly  Tyr Arg Leu Thr Val  Gly Leu Thr Arg Arg  Gly Gln Pro 
    1115                 1120                 1125             


Arg Gln  Tyr Asn Val Gly Pro  Ser Val Ser Lys Tyr  Pro Leu Arg 
    1130                 1135                 1140             


Asn Leu  Gln Pro Ala Ser Glu  Tyr Thr Val Ser Leu  Val Ala Ile 
    1145                 1150                 1155             


Lys Gly  Asn Gln Glu Ser Pro  Lys Ala Thr Gly Val  Phe Thr Thr 
    1160                 1165                 1170             


Leu Gln  Pro Gly Ser Ser Ile  Pro Pro Tyr Asn Thr  Glu Val Thr 
    1175                 1180                 1185             


Glu Thr  Thr Ile Val Ile Thr  Trp Thr Pro Ala Pro  Arg Ile Gly 
    1190                 1195                 1200             


Phe Lys  Leu Gly Val Arg Pro  Ser Gln Gly Gly Glu  Ala Pro Arg 
    1205                 1210                 1215             


Glu Val  Thr Ser Asp Ser Gly  Ser Ile Val Val Ser  Gly Leu Thr 
    1220                 1225                 1230             


Pro Gly  Val Glu Tyr Val Tyr  Thr Ile Gln Val Leu  Arg Asp Gly 
    1235                 1240                 1245             


Gln Glu  Arg Asp Ala Pro Ile  Val Asn Lys Val Val  Thr Pro Leu 
    1250                 1255                 1260             


Ser Pro  Pro Thr Asn Leu His  Leu Glu Ala Asn Pro  Asp Thr Gly 
    1265                 1270                 1275             


Val Leu  Thr Val Ser Trp Glu  Arg Ser Thr Thr Pro  Asp Ile Thr 
    1280                 1285                 1290             


Gly Tyr  Arg Ile Thr Thr Thr  Pro Thr Asn Gly Gln  Gln Gly Asn 
    1295                 1300                 1305             


Ser Leu  Glu Glu Val Val His  Ala Asp Gln Ser Ser  Cys Thr Phe 
    1310                 1315                 1320             


Asp Asn  Leu Ser Pro Gly Leu  Glu Tyr Asn Val Ser  Val Tyr Thr 
    1325                 1330                 1335             


Val Lys  Asp Asp Lys Glu Ser  Val Pro Ile Ser Asp  Thr Ile Ile 
    1340                 1345                 1350             


Pro Ala  Val Pro Pro Pro Thr  Asp Leu Arg Phe Thr  Asn Ile Gly 
    1355                 1360                 1365             


Pro Asp  Thr Met Arg Val Thr  Trp Ala Pro Pro Pro  Ser Ile Asp 
    1370                 1375                 1380             


Leu Thr  Asn Phe Leu Val Arg  Tyr Ser Pro Val Lys  Asn Glu Glu 
    1385                 1390                 1395             


Asp Val  Ala Glu Leu Ser Ile  Ser Pro Ser Asp Asn  Ala Val Val 
    1400                 1405                 1410             


Leu Thr  Asn Leu Leu Pro Gly  Thr Glu Tyr Val Val  Ser Val Ser 
    1415                 1420                 1425             


Ser Val  Tyr Glu Gln His Glu  Ser Thr Pro Leu Arg  Gly Arg Gln 
    1430                 1435                 1440             


Lys Thr  Gly Leu Asp Ser Pro  Thr Gly Ile Asp Phe  Ser Asp Ile 
    1445                 1450                 1455             


Thr Ala  Asn Ser Phe Thr Val  His Trp Ile Ala Pro  Arg Ala Thr 
    1460                 1465                 1470             


Ile Thr  Gly Tyr Arg Ile Arg  His His Pro Glu His  Phe Ser Gly 
    1475                 1480                 1485             


Arg Pro  Arg Glu Asp Arg Val  Pro His Ser Arg Asn  Ser Ile Thr 
    1490                 1495                 1500             


Leu Thr  Asn Leu Thr Pro Gly  Thr Glu Tyr Val Val  Ser Ile Val 
    1505                 1510                 1515             


Ala Leu  Asn Gly Arg Glu Glu  Ser Pro Leu Leu Ile  Gly Gln Gln 
    1520                 1525                 1530             


Ser Thr  Val Ser Asp Val Pro  Arg Asp Leu Glu Val  Val Ala Ala 
    1535                 1540                 1545             


Thr Pro  Thr Ser Leu Leu Ile  Ser Trp Asp Ala Pro  Ala Val Thr 
    1550                 1555                 1560             


Val Arg  Tyr Tyr Arg Ile Thr  Tyr Gly Glu Thr Gly  Gly Asn Ser 
    1565                 1570                 1575             


Pro Val  Gln Glu Phe Thr Val  Pro Gly Ser Lys Ser  Thr Ala Thr 
    1580                 1585                 1590             


Ile Ser  Gly Leu Lys Pro Gly  Val Asp Tyr Thr Ile  Thr Val Tyr 
    1595                 1600                 1605             


Ala Val  Thr Gly Arg Gly Asp  Ser Pro Ala Ser Ser  Lys Pro Ile 
    1610                 1615                 1620             


Ser Ile  Asn Tyr Arg Thr Glu  Ile Asp Lys Pro Ser  Gln Met Gln 
    1625                 1630                 1635             


Val Thr  Asp Val Gln Asp Asn  Ser Ile Ser Val Lys  Trp Leu Pro 
    1640                 1645                 1650             


Ser Ser  Ser Pro Val Thr Gly  Tyr Arg Val Thr Thr  Thr Pro Lys 
    1655                 1660                 1665             


Asn Gly  Pro Gly Pro Thr Lys  Thr Lys Thr Ala Gly  Pro Asp Gln 
    1670                 1675                 1680             


Thr Glu  Met Thr Ile Glu Gly  Leu Gln Pro Thr Val  Glu Tyr Val 
    1685                 1690                 1695             


Val Ser  Val Tyr Ala Gln Asn  Pro Ser Gly Glu Ser  Gln Pro Leu 
    1700                 1705                 1710             


Val Gln  Thr Ala Val Thr Asn  Ile Asp Arg Pro Lys  Gly Leu Ala 
    1715                 1720                 1725             


Phe Thr  Asp Val Asp Val Asp  Ser Ile Lys Ile Ala  Trp Glu Ser 
    1730                 1735                 1740             


Pro Gln  Gly Gln Val Ser Arg  Tyr Arg Val Thr Tyr  Ser Ser Pro 
    1745                 1750                 1755             


Glu Asp  Gly Ile His Glu Leu  Phe Pro Ala Pro Asp  Gly Glu Glu 
    1760                 1765                 1770             


Asp Thr  Ala Glu Leu Gln Gly  Leu Arg Pro Gly Ser  Glu Tyr Thr 
    1775                 1780                 1785             


Val Ser  Val Val Ala Leu His  Asp Asp Met Glu Ser  Gln Pro Leu 
    1790                 1795                 1800             


Ile Gly  Thr Gln Ser Thr Ala  Ile Pro Ala Pro Ala  Asp Leu Lys 
    1805                 1810                 1815             


Phe Thr  Gln Val Thr Pro Thr  Ser Leu Ser Ala Gln  Trp Thr Pro 
    1820                 1825                 1830             


Pro Asn  Val Gln Leu Thr Gly  Tyr Arg Val Arg Val  Thr Pro Lys 
    1835                 1840                 1845             


Glu Lys  Thr Gly Pro Met Lys  Glu Ile Asn Leu Ala  Pro Asp Ser 
    1850                 1855                 1860             


Ser Ser  Val Val Val Ser Gly  Leu Met Val Ala Thr  Lys Tyr Glu 
    1865                 1870                 1875             


Val Ser  Val Tyr Ala Leu Lys  Asp Thr Leu Thr Ser  Arg Pro Ala 
    1880                 1885                 1890             


Gln Gly  Val Val Thr Thr Leu  Glu Asn Val Ser Pro  Pro Arg Arg 
    1895                 1900                 1905             


Ala Arg  Val Thr Asp Ala Thr  Glu Thr Thr Ile Thr  Ile Ser Trp 
    1910                 1915                 1920             


Arg Thr  Lys Thr Glu Thr Ile  Thr Gly Phe Gln Val  Asp Ala Val 
    1925                 1930                 1935             


Pro Ala  Asn Gly Gln Thr Pro  Ile Gln Arg Thr Ile  Lys Pro Asp 
    1940                 1945                 1950             


Val Arg  Ser Tyr Thr Ile Thr  Gly Leu Gln Pro Gly  Thr Asp Tyr 
    1955                 1960                 1965             


Lys Ile  Tyr Leu Tyr Thr Leu  Asn Asp Asn Ala Arg  Ser Ser Pro 
    1970                 1975                 1980             


Val Val  Ile Asp Ala Ser Thr  Ala Ile Asp Ala Pro  Ser Asn Leu 
    1985                 1990                 1995             


Arg Phe  Leu Ala Thr Thr Pro  Asn Ser Leu Leu Val  Ser Trp Gln 
    2000                 2005                 2010             


Pro Pro  Arg Ala Arg Ile Thr  Gly Tyr Ile Ile Lys  Tyr Glu Lys 
    2015                 2020                 2025             


Pro Gly  Ser Pro Pro Arg Glu  Val Val Pro Arg Pro  Arg Pro Gly 
    2030                 2035                 2040             


Val Thr  Glu Ala Thr Ile Thr  Gly Leu Glu Pro Gly  Thr Glu Tyr 
    2045                 2050                 2055             


Thr Ile  Tyr Val Ile Ala Leu  Lys Asn Asn Gln Lys  Ser Glu Pro 
    2060                 2065                 2070             


Leu Ile  Gly Arg Lys Lys Thr  Asp Glu Leu Pro Gln  Leu Val Thr 
    2075                 2080                 2085             


Leu Pro  His Pro Asn Leu His  Gly Pro Glu Ile Leu  Asp Val Pro 
    2090                 2095                 2100             


Ser Thr  Val Gln Lys Thr Pro  Phe Val Thr His Pro  Gly Tyr Asp 
    2105                 2110                 2115             


Thr Gly  Asn Gly Ile Gln Leu  Pro Gly Thr Ser Gly  Gln Gln Pro 
    2120                 2125                 2130             


Ser Val  Gly Gln Gln Met Ile  Phe Glu Glu His Gly  Phe Arg Arg 
    2135                 2140                 2145             


Thr Thr  Pro Pro Thr Thr Ala  Thr Pro Ile Arg His  Arg Pro Arg 
    2150                 2155                 2160             


Pro Tyr  Pro Pro Asn Val Gly  Gln Glu Ala Leu Ser  Gln Thr Thr 
    2165                 2170                 2175             


Ile Ser  Trp Ala Pro Phe Gln  Asp Thr Ser Glu Tyr  Ile Ile Ser 
    2180                 2185                 2190             


Cys His  Pro Val Gly Thr Asp  Glu Glu Pro Leu Gln  Phe Arg Val 
    2195                 2200                 2205             


Pro Gly  Thr Ser Thr Ser Ala  Thr Leu Thr Gly Leu  Thr Arg Gly 
    2210                 2215                 2220             


Ala Thr  Tyr Asn Ile Ile Val  Glu Ala Leu Lys Asp  Gln Gln Arg 
    2225                 2230                 2235             


His Lys  Val Arg Glu Glu Val  Val Thr Val Gly Asn  Ser Val Asn 
    2240                 2245                 2250             


Glu Gly  Leu Asn Gln Pro Thr  Asp Asp Ser Cys Phe  Asp Pro Tyr 
    2255                 2260                 2265             


Thr Val  Ser His Tyr Ala Val  Gly Asp Glu Trp Glu  Arg Met Ser 
    2270                 2275                 2280             


Glu Ser  Gly Phe Lys Leu Leu  Cys Gln Cys Leu Gly  Phe Gly Ser 
    2285                 2290                 2295             


Gly His  Phe Arg Cys Asp Ser  Ser Arg Trp Cys His  Asp Asn Gly 
    2300                 2305                 2310             


Val Asn  Tyr Lys Ile Gly Glu  Lys Trp Asp Arg Gln  Gly Glu Asn 
    2315                 2320                 2325             


Gly Gln  Met Met Ser Cys Thr  Cys Leu Gly Asn Gly  Lys Gly Glu 
    2330                 2335                 2340             


Phe Lys  Cys Asp Pro His Glu  Ala Thr Cys Tyr Asp  Asp Gly Lys 
    2345                 2350                 2355             


Thr Tyr  His Val Gly Glu Gln  Trp Gln Lys Glu Tyr  Leu Gly Ala 
    2360                 2365                 2370             


Ile Cys  Ser Cys Thr Cys Phe  Gly Gly Gln Arg Gly  Trp Arg Cys 
    2375                 2380                 2385             


Asp Asn  Cys Arg Arg Pro Gly  Gly Glu Pro Ser Pro  Glu Gly Thr 
    2390                 2395                 2400             


Thr Gly  Gln Ser Tyr Asn Gln  Tyr Ser Gln Arg Tyr  His Gln Arg 
    2405                 2410                 2415             


Thr Asn  Thr Asn Val Asn Cys  Pro Ile Glu Cys Phe  Met Pro Leu 
    2420                 2425                 2430             


Asp Val  Gln Ala Asp Arg Glu  Asp Ser Arg Glu 
    2435                 2440                 


<210>  29
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ile Ile Glu Pro 
65                  70                  75                  80  


Ser Leu Arg Gln Leu Ala Gln Lys Tyr Asn Cys Asp Lys Met Ile Cys 
                85                  90                  95      


Arg Lys Cys Tyr Ala Arg Leu His Pro Arg Ala Val Asn Cys Arg Lys 
            100                 105                 110         


Lys Lys Cys Gly His Thr Asn Asn Leu Arg Pro Lys Lys Lys Val Lys 
        115                 120                 125             


<210>  30
<211>  4391
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 
            500                 505                 510         


Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser 
        515                 520                 525             


Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe 
    530                 535                 540                 


Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln 
545                 550                 555                 560 


Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser 
                565                 570                 575     


Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val His 
            580                 585                 590         


Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val Asp 
        595                 600                 605             


Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala Arg 
    610                 615                 620                 


Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Met Gly Ala 
625                 630                 635                 640 


Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala 
                645                 650                 655     


Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu 
            660                 665                 670         


Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser 
        675                 680                 685             


Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala Ser 
    690                 695                 700                 


Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala Thr 
705                 710                 715                 720 


Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly 
                725                 730                 735     


Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val 
            740                 745                 750         


Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn Gly 
        755                 760                 765             


His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 
    770                 775                 780                 


His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe 
785                 790                 795                 800 


Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro Cys 
                805                 810                 815     


Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp 
            820                 825                 830         


Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly 
        835                 840                 845             


Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln 
    850                 855                 860                 


Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys Asp 
865                 870                 875                 880 


Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn 
                885                 890                 895     


Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His 
            900                 905                 910         


Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly 
        915                 920                 925             


Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu His 
    930                 935                 940                 


Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala Ser 
945                 950                 955                 960 


Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu 
                965                 970                 975     


Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser 
            980                 985                 990         


Leu Pro Ser Arg Phe Leu Gly Asp  Lys Val Thr Ser Tyr  Gly Gly Glu 
        995                 1000                 1005             


Leu Arg  Phe Thr Val Thr Gln  Arg Ser Gln Pro Gly  Ser Thr Pro 
    1010                 1015                 1020             


Leu His  Gly Gln Pro Leu Val  Val Leu Gln Gly Asn  Asn Ile Ile 
    1025                 1030                 1035             


Leu Glu  His His Val Ala Gln  Glu Pro Ser Pro Gly  Gln Pro Ser 
    1040                 1045                 1050             


Thr Phe  Ile Val Pro Phe Arg  Glu Gln Ala Trp Gln  Arg Pro Asp 
    1055                 1060                 1065             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Gly 
    1070                 1075                 1080             


Ile Asp  Thr Leu Leu Ile Arg  Ala Ser Tyr Ala Gln  Gln Pro Ala 
    1085                 1090                 1095             


Glu Ser  Arg Val Ser Gly Ile  Ser Met Asp Val Ala  Val Pro Glu 
    1100                 1105                 1110             


Glu Thr  Gly Gln Asp Pro Ala  Leu Glu Val Glu Gln  Cys Ser Cys 
    1115                 1120                 1125             


Pro Pro  Gly Tyr Arg Gly Pro  Ser Cys Gln Asp Cys  Asp Thr Gly 
    1130                 1135                 1140             


Tyr Thr  Arg Thr Pro Ser Gly  Leu Tyr Leu Gly Thr  Cys Glu Arg 
    1145                 1150                 1155             


Cys Ser  Cys His Gly His Ser  Glu Ala Cys Glu Pro  Glu Thr Gly 
    1160                 1165                 1170             


Ala Cys  Gln Gly Cys Gln His  His Thr Glu Gly Pro  Arg Cys Glu 
    1175                 1180                 1185             


Gln Cys  Gln Pro Gly Tyr Tyr  Gly Asp Ala Gln Arg  Gly Thr Pro 
    1190                 1195                 1200             


Gln Asp  Cys Gln Leu Cys Pro  Cys Tyr Gly Asp Pro  Ala Ala Gly 
    1205                 1210                 1215             


Gln Ala  Ala His Thr Cys Phe  Leu Asp Thr Asp Gly  His Pro Thr 
    1220                 1225                 1230             


Cys Asp  Ala Cys Ser Pro Gly  His Ser Gly Arg His  Cys Glu Arg 
    1235                 1240                 1245             


Cys Ala  Pro Gly Tyr Tyr Gly  Asn Pro Ser Gln Gly  Gln Pro Cys 
    1250                 1255                 1260             


Gln Arg  Asp Ser Gln Val Pro  Gly Pro Ile Gly Cys  Asn Cys Asp 
    1265                 1270                 1275             


Pro Gln  Gly Ser Val Ser Ser  Gln Cys Asp Ala Ala  Gly Gln Cys 
    1280                 1285                 1290             


Gln Cys  Lys Ala Gln Val Glu  Gly Leu Thr Cys Ser  His Cys Arg 
    1295                 1300                 1305             


Pro His  His Phe His Leu Ser  Ala Ser Asn Pro Asp  Gly Cys Leu 
    1310                 1315                 1320             


Pro Cys  Phe Cys Met Gly Ile  Thr Gln Gln Cys Ala  Ser Ser Ala 
    1325                 1330                 1335             


Tyr Thr  Arg His Leu Ile Ser  Thr His Phe Ala Pro  Gly Asp Phe 
    1340                 1345                 1350             


Gln Gly  Phe Ala Leu Val Asn  Pro Gln Arg Asn Ser  Arg Leu Thr 
    1355                 1360                 1365             


Gly Glu  Phe Thr Val Glu Pro  Val Pro Glu Gly Ala  Gln Leu Ser 
    1370                 1375                 1380             


Phe Gly  Asn Phe Ala Gln Leu  Gly His Glu Ser Phe  Tyr Trp Gln 
    1385                 1390                 1395             


Leu Pro  Glu Thr Tyr Gln Gly  Asp Lys Val Ala Ala  Tyr Gly Gly 
    1400                 1405                 1410             


Lys Leu  Arg Tyr Thr Leu Ser  Tyr Thr Ala Gly Pro  Gln Gly Ser 
    1415                 1420                 1425             


Pro Leu  Ser Asp Pro Asp Val  Gln Ile Thr Gly Asn  Asn Ile Met 
    1430                 1435                 1440             


Leu Val  Ala Ser Gln Pro Ala  Leu Gln Gly Pro Glu  Arg Arg Ser 
    1445                 1450                 1455             


Tyr Glu  Ile Met Phe Arg Glu  Glu Phe Trp Arg Arg  Pro Asp Gly 
    1460                 1465                 1470             


Gln Pro  Ala Thr Arg Glu His  Leu Leu Met Ala Leu  Ala Asp Leu 
    1475                 1480                 1485             


Asp Glu  Leu Leu Ile Arg Ala  Thr Phe Ser Ser Val  Pro Leu Ala 
    1490                 1495                 1500             


Ala Ser  Ile Ser Ala Val Ser  Leu Glu Val Ala Gln  Pro Gly Pro 
    1505                 1510                 1515             


Ser Asn  Arg Pro Arg Ala Leu  Glu Val Glu Glu Cys  Arg Cys Pro 
    1520                 1525                 1530             


Pro Gly  Tyr Ile Gly Leu Ser  Cys Gln Asp Cys Ala  Pro Gly Tyr 
    1535                 1540                 1545             


Thr Arg  Thr Gly Ser Gly Leu  Tyr Leu Gly His Cys  Glu Leu Cys 
    1550                 1555                 1560             


Glu Cys  Asn Gly His Ser Asp  Leu Cys His Pro Glu  Thr Gly Ala 
    1565                 1570                 1575             


Cys Ser  Gln Cys Gln His Asn  Ala Ala Gly Glu Phe  Cys Glu Leu 
    1580                 1585                 1590             


Cys Ala  Pro Gly Tyr Tyr Gly  Asp Ala Thr Ala Gly  Thr Pro Glu 
    1595                 1600                 1605             


Asp Cys  Gln Pro Cys Ala Cys  Pro Leu Thr Asn Pro  Glu Asn Met 
    1610                 1615                 1620             


Phe Ser  Arg Thr Cys Glu Ser  Leu Gly Ala Gly Gly  Tyr Arg Cys 
    1625                 1630                 1635             


Thr Ala  Cys Glu Pro Gly Tyr  Thr Gly Gln Tyr Cys  Glu Gln Cys 
    1640                 1645                 1650             


Gly Pro  Gly Tyr Val Gly Asn  Pro Ser Val Gln Gly  Gly Gln Cys 
    1655                 1660                 1665             


Leu Pro  Glu Thr Asn Gln Ala  Pro Leu Val Val Glu  Val His Pro 
    1670                 1675                 1680             


Ala Arg  Ser Ile Val Pro Gln  Gly Gly Ser His Ser  Leu Arg Cys 
    1685                 1690                 1695             


Gln Val  Ser Gly Ser Pro Pro  His Tyr Phe Tyr Trp  Ser Arg Glu 
    1700                 1705                 1710             


Asp Gly  Arg Pro Val Pro Ser  Gly Thr Gln Gln Arg  His Gln Gly 
    1715                 1720                 1725             


Ser Glu  Leu His Phe Pro Ser  Val Gln Pro Ser Asp  Ala Gly Val 
    1730                 1735                 1740             


Tyr Ile  Cys Thr Cys Arg Asn  Leu His Gln Ser Asn  Thr Ser Arg 
    1745                 1750                 1755             


Ala Glu  Leu Leu Val Thr Glu  Ala Pro Ser Lys Pro  Ile Thr Val 
    1760                 1765                 1770             


Thr Val  Glu Glu Gln Arg Ser  Gln Ser Val Arg Pro  Gly Ala Asp 
    1775                 1780                 1785             


Val Thr  Phe Ile Cys Thr Ala  Lys Ser Lys Ser Pro  Ala Tyr Thr 
    1790                 1795                 1800             


Leu Val  Trp Thr Arg Leu His  Asn Gly Lys Leu Pro  Thr Arg Ala 
    1805                 1810                 1815             


Met Asp  Phe Asn Gly Ile Leu  Thr Ile Arg Asn Val  Gln Leu Ser 
    1820                 1825                 1830             


Asp Ala  Gly Thr Tyr Val Cys  Thr Gly Ser Asn Met  Phe Ala Met 
    1835                 1840                 1845             


Asp Gln  Gly Thr Ala Thr Leu  His Val Gln Ala Ser  Gly Thr Leu 
    1850                 1855                 1860             


Ser Ala  Pro Val Val Ser Ile  His Pro Pro Gln Leu  Thr Val Gln 
    1865                 1870                 1875             


Pro Gly  Gln Leu Ala Glu Phe  Arg Cys Ser Ala Thr  Gly Ser Pro 
    1880                 1885                 1890             


Thr Pro  Thr Leu Glu Trp Thr  Gly Gly Pro Gly Gly  Gln Leu Pro 
    1895                 1900                 1905             


Ala Lys  Ala Gln Ile His Gly  Gly Ile Leu Arg Leu  Pro Ala Val 
    1910                 1915                 1920             


Glu Pro  Thr Asp Gln Ala Gln  Tyr Leu Cys Arg Ala  His Ser Ser 
    1925                 1930                 1935             


Ala Gly  Gln Gln Val Ala Arg  Ala Val Leu His Val  His Gly Gly 
    1940                 1945                 1950             


Gly Gly  Pro Arg Val Gln Val  Ser Pro Glu Arg Thr  Gln Val His 
    1955                 1960                 1965             


Ala Gly  Arg Thr Val Arg Leu  Tyr Cys Arg Ala Ala  Gly Val Pro 
    1970                 1975                 1980             


Ser Ala  Thr Ile Thr Trp Arg  Lys Glu Gly Gly Ser  Leu Pro Pro 
    1985                 1990                 1995             


Gln Ala  Arg Ser Glu Arg Thr  Asp Ile Ala Thr Leu  Leu Ile Pro 
    2000                 2005                 2010             


Ala Ile  Thr Thr Ala Asp Ala  Gly Phe Tyr Leu Cys  Val Ala Thr 
    2015                 2020                 2025             


Ser Pro  Ala Gly Thr Ala Gln  Ala Arg Ile Gln Val  Val Val Leu 
    2030                 2035                 2040             


Ser Ala  Ser Asp Ala Ser Pro  Pro Pro Val Lys Ile  Glu Ser Ser 
    2045                 2050                 2055             


Ser Pro  Ser Val Thr Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val 
    2060                 2065                 2070             


Val Ala  Gly Ser Ala His Ala  Gln Val Thr Trp Tyr  Arg Arg Gly 
    2075                 2080                 2085             


Gly Ser  Leu Pro Pro His Thr  Gln Val His Gly Ser  Arg Leu Arg 
    2090                 2095                 2100             


Leu Pro  Gln Val Ser Pro Ala  Asp Ser Gly Glu Tyr  Val Cys Arg 
    2105                 2110                 2115             


Val Glu  Asn Gly Ser Gly Pro  Lys Glu Ala Ser Ile  Thr Val Ser 
    2120                 2125                 2130             


Val Leu  His Gly Thr His Ser  Gly Pro Ser Tyr Thr  Pro Val Pro 
    2135                 2140                 2145             


Gly Ser  Thr Arg Pro Ile Arg  Ile Glu Pro Ser Ser  Ser His Val 
    2150                 2155                 2160             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln 
    2165                 2170                 2175             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2180                 2185                 2190             


Ala Arg  His Gln Thr His Gly  Ser Leu Leu Arg Leu  His Gln Val 
    2195                 2200                 2205             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys His Val  Val Gly Thr 
    2210                 2215                 2220             


Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Ala Ser 
    2225                 2230                 2235             


Val Ile  Pro Gly Pro Ile Pro  Pro Val Arg Ile Glu  Ser Ser Ser 
    2240                 2245                 2250             


Ser Thr  Val Ala Glu Gly Gln  Thr Leu Asp Leu Ser  Cys Val Val 
    2255                 2260                 2265             


Ala Gly  Gln Ala His Ala Gln  Val Thr Trp Tyr Lys  Arg Gly Gly 
    2270                 2275                 2280             


Ser Leu  Pro Ala Arg His Gln  Val Arg Gly Ser Arg  Leu Tyr Ile 
    2285                 2290                 2295             


Phe Gln  Ala Ser Pro Ala Asp  Ala Gly Gln Tyr Val  Cys Arg Ala 
    2300                 2305                 2310             


Ser Asn  Gly Met Glu Ala Ser  Ile Thr Val Thr Val  Thr Gly Thr 
    2315                 2320                 2325             


Gln Gly  Ala Asn Leu Ala Tyr  Pro Ala Gly Ser Thr  Gln Pro Ile 
    2330                 2335                 2340             


Arg Ile  Glu Pro Ser Ser Ser  Gln Val Ala Glu Gly  Gln Thr Leu 
    2345                 2350                 2355             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ser His Ala  Gln Val Thr 
    2360                 2365                 2370             


Trp His  Lys Arg Gly Gly Ser  Leu Pro Val Arg His  Gln Thr His 
    2375                 2380                 2385             


Gly Ser  Leu Leu Arg Leu Tyr  Gln Ala Ser Pro Ala  Asp Ser Gly 
    2390                 2395                 2400             


Glu Tyr  Val Cys Arg Val Leu  Gly Ser Ser Val Pro  Leu Glu Ala 
    2405                 2410                 2415             


Ser Val  Leu Val Thr Ile Glu  Pro Ala Gly Ser Val  Pro Ala Leu 
    2420                 2425                 2430             


Gly Val  Thr Pro Thr Val Arg  Ile Glu Ser Ser Ser  Ser Gln Val 
    2435                 2440                 2445             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Leu Val  Ala Gly Gln 
    2450                 2455                 2460             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2465                 2470                 2475             


Ala Arg  His Gln Val His Gly  Ser Arg Leu Arg Leu  Leu Gln Val 
    2480                 2485                 2490             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys Arg Val  Val Gly Ser 
    2495                 2500                 2505             


Ser Gly  Thr Gln Glu Ala Ser  Val Leu Val Thr Ile  Gln Gln Arg 
    2510                 2515                 2520             


Leu Ser  Gly Ser His Ser Gln  Gly Val Ala Tyr Pro  Val Arg Ile 
    2525                 2530                 2535             


Glu Ser  Ser Ser Ala Ser Leu  Ala Asn Gly His Thr  Leu Asp Leu 
    2540                 2545                 2550             


Asn Cys  Leu Val Ala Ser Gln  Ala Pro His Thr Ile  Thr Trp Tyr 
    2555                 2560                 2565             


Lys Arg  Gly Gly Ser Leu Pro  Ser Arg His Gln Ile  Val Gly Ser 
    2570                 2575                 2580             


Arg Leu  Arg Ile Pro Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr 
    2585                 2590                 2595             


Val Cys  His Val Ser Asn Gly  Ala Gly Ser Arg Glu  Thr Ser Leu 
    2600                 2605                 2610             


Ile Val  Thr Ile Gln Gly Ser  Gly Ser Ser His Val  Pro Ser Val 
    2615                 2620                 2625             


Ser Pro  Pro Ile Arg Ile Glu  Ser Ser Ser Pro Thr  Val Val Glu 
    2630                 2635                 2640             


Gly Gln  Thr Leu Asp Leu Asn  Cys Val Val Ala Arg  Gln Pro Gln 
    2645                 2650                 2655             


Ala Ile  Ile Thr Trp Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg 
    2660                 2665                 2670             


His Gln  Thr His Gly Ser His  Leu Arg Leu His Gln  Met Ser Val 
    2675                 2680                 2685             


Ala Asp  Ser Gly Glu Tyr Val  Cys Arg Ala Asn Asn  Asn Ile Asp 
    2690                 2695                 2700             


Ala Leu  Glu Ala Ser Ile Val  Ile Ser Val Ser Pro  Ser Ala Gly 
    2705                 2710                 2715             


Ser Pro  Ser Ala Pro Gly Ser  Ser Met Pro Ile Arg  Ile Glu Ser 
    2720                 2725                 2730             


Ser Ser  Ser His Val Ala Glu  Gly Glu Thr Leu Asp  Leu Asn Cys 
    2735                 2740                 2745             


Val Val  Pro Gly Gln Ala His  Ala Gln Val Thr Trp  His Lys Arg 
    2750                 2755                 2760             


Gly Gly  Ser Leu Pro Ser His  His Gln Thr Arg Gly  Ser Arg Leu 
    2765                 2770                 2775             


Arg Leu  His His Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2780                 2785                 2790             


Arg Val  Met Gly Ser Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val 
    2795                 2800                 2805             


Thr Ile  Glu Ala Ser Gly Ser  Ser Ala Val His Val  Pro Ala Pro 
    2810                 2815                 2820             


Gly Gly  Ala Pro Pro Ile Arg  Ile Glu Pro Ser Ser  Ser Arg Val 
    2825                 2830                 2835             


Ala Glu  Gly Gln Thr Leu Asp  Leu Lys Cys Val Val  Pro Gly Gln 
    2840                 2845                 2850             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Asn Leu Pro 
    2855                 2860                 2865             


Ala Arg  His Gln Val His Gly  Pro Leu Leu Arg Leu  Asn Gln Val 
    2870                 2875                 2880             


Ser Pro  Ala Asp Ser Gly Glu  Tyr Ser Cys Gln Val  Thr Gly Ser 
    2885                 2890                 2895             


Ser Gly  Thr Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Pro Ser 
    2900                 2905                 2910             


Ser Pro  Gly Pro Ile Pro Ala  Pro Gly Leu Ala Gln  Pro Ile Tyr 
    2915                 2920                 2925             


Ile Glu  Ala Ser Ser Ser His  Val Thr Glu Gly Gln  Thr Leu Asp 
    2930                 2935                 2940             


Leu Asn  Cys Val Val Pro Gly  Gln Ala His Ala Gln  Val Thr Trp 
    2945                 2950                 2955             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ala Arg His Gln  Thr His Gly 
    2960                 2965                 2970             


Ser Gln  Leu Arg Leu His Leu  Val Ser Pro Ala Asp  Ser Gly Glu 
    2975                 2980                 2985             


Tyr Val  Cys Arg Ala Ala Ser  Gly Pro Gly Pro Glu  Gln Glu Ala 
    2990                 2995                 3000             


Ser Phe  Thr Val Thr Val Pro  Pro Ser Glu Gly Ser  Ser Tyr Arg 
    3005                 3010                 3015             


Leu Arg  Ser Pro Val Ile Ser  Ile Asp Pro Pro Ser  Ser Thr Val 
    3020                 3025                 3030             


Gln Gln  Gly Gln Asp Ala Ser  Phe Lys Cys Leu Ile  His Asp Gly 
    3035                 3040                 3045             


Ala Ala  Pro Ile Ser Leu Glu  Trp Lys Thr Arg Asn  Gln Glu Leu 
    3050                 3055                 3060             


Glu Asp  Asn Val His Ile Ser  Pro Asn Gly Ser Ile  Ile Thr Ile 
    3065                 3070                 3075             


Val Gly  Thr Arg Pro Ser Asn  His Gly Thr Tyr Arg  Cys Val Ala 
    3080                 3085                 3090             


Ser Asn  Ala Tyr Gly Val Ala  Gln Ser Val Val Asn  Leu Ser Val 
    3095                 3100                 3105             


His Gly  Pro Pro Thr Val Ser  Val Leu Pro Glu Gly  Pro Val Trp 
    3110                 3115                 3120             


Val Lys  Val Gly Lys Ala Val  Thr Leu Glu Cys Val  Ser Ala Gly 
    3125                 3130                 3135             


Glu Pro  Arg Ser Ser Ala Arg  Trp Thr Arg Ile Ser  Ser Thr Pro 
    3140                 3145                 3150             


Ala Lys  Leu Glu Gln Arg Thr  Tyr Gly Leu Met Asp  Ser His Ala 
    3155                 3160                 3165             


Val Leu  Gln Ile Ser Ser Ala  Lys Pro Ser Asp Ala  Gly Thr Tyr 
    3170                 3175                 3180             


Val Cys  Leu Ala Gln Asn Ala  Leu Gly Thr Ala Gln  Lys Gln Val 
    3185                 3190                 3195             


Glu Val  Ile Val Asp Thr Gly  Ala Met Ala Pro Gly  Ala Pro Gln 
    3200                 3205                 3210             


Val Gln  Ala Glu Glu Ala Glu  Leu Thr Val Glu Ala  Gly His Thr 
    3215                 3220                 3225             


Ala Thr  Leu Arg Cys Ser Ala  Thr Gly Ser Pro Ala  Pro Thr Ile 
    3230                 3235                 3240             


His Trp  Ser Lys Leu Arg Ser  Pro Leu Pro Trp Gln  His Arg Leu 
    3245                 3250                 3255             


Glu Gly  Asp Thr Leu Ile Ile  Pro Arg Val Ala Gln  Gln Asp Ser 
    3260                 3265                 3270             


Gly Gln  Tyr Ile Cys Asn Ala  Thr Ser Pro Ala Gly  His Ala Glu 
    3275                 3280                 3285             


Ala Thr  Ile Ile Leu His Val  Glu Ser Pro Pro Tyr  Ala Thr Thr 
    3290                 3295                 3300             


Val Pro  Glu His Ala Ser Val  Gln Ala Gly Glu Thr  Val Gln Leu 
    3305                 3310                 3315             


Gln Cys  Leu Ala His Gly Thr  Pro Pro Leu Thr Phe  Gln Trp Ser 
    3320                 3325                 3330             


Arg Val  Gly Ser Ser Leu Pro  Gly Arg Ala Thr Ala  Arg Asn Glu 
    3335                 3340                 3345             


Leu Leu  His Phe Glu Arg Ala  Ala Pro Glu Asp Ser  Gly Arg Tyr 
    3350                 3355                 3360             


Arg Cys  Arg Val Thr Asn Lys  Val Gly Ser Ala Glu  Ala Phe Ala 
    3365                 3370                 3375             


Gln Leu  Leu Val Gln Gly Pro  Pro Gly Ser Leu Pro  Ala Thr Ser 
    3380                 3385                 3390             


Ile Pro  Ala Gly Ser Thr Pro  Thr Val Gln Val Thr  Pro Gln Leu 
    3395                 3400                 3405             


Glu Thr  Lys Ser Ile Gly Ala  Ser Val Glu Phe His  Cys Ala Val 
    3410                 3415                 3420             


Pro Ser  Asp Arg Gly Thr Gln  Leu Arg Trp Phe Lys  Glu Gly Gly 
    3425                 3430                 3435             


Gln Leu  Pro Pro Gly His Ser  Val Gln Asp Gly Val  Leu Arg Ile 
    3440                 3445                 3450             


Gln Asn  Leu Asp Gln Ser Cys  Gln Gly Thr Tyr Ile  Cys Gln Ala 
    3455                 3460                 3465             


His Gly  Pro Trp Gly Lys Ala  Gln Ala Ser Ala Gln  Leu Val Ile 
    3470                 3475                 3480             


Gln Ala  Leu Pro Ser Val Leu  Ile Asn Ile Arg Thr  Ser Val Gln 
    3485                 3490                 3495             


Thr Val  Val Val Gly His Ala  Val Glu Phe Glu Cys  Leu Ala Leu 
    3500                 3505                 3510             


Gly Asp  Pro Lys Pro Gln Val  Thr Trp Ser Lys Val  Gly Gly His 
    3515                 3520                 3525             


Leu Arg  Pro Gly Ile Val Gln  Ser Gly Gly Val Val  Arg Ile Ala 
    3530                 3535                 3540             


His Val  Glu Leu Ala Asp Ala  Gly Gln Tyr Arg Cys  Thr Ala Thr 
    3545                 3550                 3555             


Asn Ala  Ala Gly Thr Thr Gln  Ser His Val Leu Leu  Leu Val Gln 
    3560                 3565                 3570             


Ala Leu  Pro Gln Ile Ser Met  Pro Gln Glu Val Arg  Val Pro Ala 
    3575                 3580                 3585             


Gly Ser  Ala Ala Val Phe Pro  Cys Ile Ala Ser Gly  Tyr Pro Thr 
    3590                 3595                 3600             


Pro Asp  Ile Ser Trp Ser Lys  Leu Asp Gly Ser Leu  Pro Pro Asp 
    3605                 3610                 3615             


Ser Arg  Leu Glu Asn Asn Met  Leu Met Leu Pro Ser  Val Arg Pro 
    3620                 3625                 3630             


Gln Asp  Ala Gly Thr Tyr Val  Cys Thr Ala Thr Asn  Arg Gln Gly 
    3635                 3640                 3645             


Lys Val  Lys Ala Phe Ala His  Leu Gln Val Pro Glu  Arg Val Val 
    3650                 3655                 3660             


Pro Tyr  Phe Thr Gln Thr Pro  Tyr Ser Phe Leu Pro  Leu Pro Thr 
    3665                 3670                 3675             


Ile Lys  Asp Ala Tyr Arg Lys  Phe Glu Ile Lys Ile  Thr Phe Arg 
    3680                 3685                 3690             


Pro Asp  Ser Ala Asp Gly Met  Leu Leu Tyr Asn Gly  Gln Lys Arg 
    3695                 3700                 3705             


Val Pro  Gly Ser Pro Thr Asn  Leu Ala Asn Arg Gln  Pro Asp Phe 
    3710                 3715                 3720             


Ile Ser  Phe Gly Leu Val Gly  Gly Arg Pro Glu Phe  Arg Phe Asp 
    3725                 3730                 3735             


Ala Gly  Ser Gly Met Ala Thr  Ile Arg His Pro Thr  Pro Leu Ala 
    3740                 3745                 3750             


Leu Gly  His Phe His Thr Val  Thr Leu Leu Arg Ser  Leu Thr Gln 
    3755                 3760                 3765             


Gly Ser  Leu Ile Val Gly Asp  Leu Ala Pro Val Asn  Gly Thr Ser 
    3770                 3775                 3780             


Gln Gly  Lys Phe Gln Gly Leu  Asp Leu Asn Glu Glu  Leu Tyr Leu 
    3785                 3790                 3795             


Gly Gly  Tyr Pro Asp Tyr Gly  Ala Ile Pro Lys Ala  Gly Leu Ser 
    3800                 3805                 3810             


Ser Gly  Phe Ile Gly Cys Val  Arg Glu Leu Arg Ile  Gln Gly Glu 
    3815                 3820                 3825             


Glu Ile  Val Phe His Asp Leu  Asn Leu Thr Ala His  Gly Ile Ser 
    3830                 3835                 3840             


His Cys  Pro Thr Cys Arg Asp  Arg Pro Cys Gln Asn  Gly Gly Gln 
    3845                 3850                 3855             


Cys His  Asp Ser Glu Ser Ser  Ser Tyr Val Cys Val  Cys Pro Ala 
    3860                 3865                 3870             


Gly Phe  Thr Gly Ser Arg Cys  Glu His Ser Gln Ala  Leu His Cys 
    3875                 3880                 3885             


His Pro  Glu Ala Cys Gly Pro  Asp Ala Thr Cys Val  Asn Arg Pro 
    3890                 3895                 3900             


Asp Gly  Arg Gly Tyr Thr Cys  Arg Cys His Leu Gly  Arg Ser Gly 
    3905                 3910                 3915             


Leu Arg  Cys Glu Glu Gly Val  Thr Val Thr Thr Pro  Ser Leu Ser 
    3920                 3925                 3930             


Gly Ala  Gly Ser Tyr Leu Ala  Leu Pro Ala Leu Thr  Asn Thr His 
    3935                 3940                 3945             


His Glu  Leu Arg Leu Asp Val  Glu Phe Lys Pro Leu  Ala Pro Asp 
    3950                 3955                 3960             


Gly Val  Leu Leu Phe Ser Gly  Gly Lys Ser Gly Pro  Val Glu Asp 
    3965                 3970                 3975             


Phe Val  Ser Leu Ala Met Val  Gly Gly His Leu Glu  Phe Arg Tyr 
    3980                 3985                 3990             


Glu Leu  Gly Ser Gly Leu Ala  Val Leu Arg Ser Ala  Glu Pro Leu 
    3995                 4000                 4005             


Ala Leu  Gly Arg Trp His Arg  Val Ser Ala Glu Arg  Leu Asn Lys 
    4010                 4015                 4020             


Asp Gly  Ser Leu Arg Val Asn  Gly Gly Arg Pro Val  Leu Arg Ser 
    4025                 4030                 4035             


Ser Pro  Gly Lys Ser Gln Gly  Leu Asn Leu His Thr  Leu Leu Tyr 
    4040                 4045                 4050             


Leu Gly  Gly Val Glu Pro Ser  Val Pro Leu Ser Pro  Ala Thr Asn 
    4055                 4060                 4065             


Met Ser  Ala His Phe Arg Gly  Cys Val Gly Glu Val  Ser Val Asn 
    4070                 4075                 4080             


Gly Lys  Arg Leu Asp Leu Thr  Tyr Ser Phe Leu Gly  Ser Gln Gly 
    4085                 4090                 4095             


Ile Gly  Gln Cys Tyr Asp Ser  Ser Pro Cys Glu Arg  Gln Pro Cys 
    4100                 4105                 4110             


Gln His  Gly Ala Thr Cys Met  Pro Ala Gly Glu Tyr  Glu Phe Gln 
    4115                 4120                 4125             


Cys Leu  Cys Arg Asp Gly Phe  Lys Gly Asp Leu Cys  Glu His Glu 
    4130                 4135                 4140             


Glu Asn  Pro Cys Gln Leu Arg  Glu Pro Cys Leu His  Gly Gly Thr 
    4145                 4150                 4155             


Cys Gln  Gly Thr Arg Cys Leu  Cys Leu Pro Gly Phe  Ser Gly Pro 
    4160                 4165                 4170             


Arg Cys  Gln Gln Gly Ser Gly  His Gly Ile Ala Glu  Ser Asp Trp 
    4175                 4180                 4185             


His Leu  Glu Gly Ser Gly Gly  Asn Asp Ala Pro Gly  Gln Tyr Gly 
    4190                 4195                 4200             


Ala Tyr  Phe His Asp Asp Gly  Phe Leu Ala Phe Pro  Gly His Val 
    4205                 4210                 4215             


Phe Ser  Arg Ser Leu Pro Glu  Val Pro Glu Thr Ile  Glu Leu Glu 
    4220                 4225                 4230             


Val Arg  Thr Ser Thr Ala Ser  Gly Leu Leu Leu Trp  Gln Gly Val 
    4235                 4240                 4245             


Glu Val  Gly Glu Ala Gly Gln  Gly Lys Asp Phe Ile  Ser Leu Gly 
    4250                 4255                 4260             


Leu Gln  Asp Gly His Leu Val  Phe Arg Tyr Gln Leu  Gly Ser Gly 
    4265                 4270                 4275             


Glu Ala  Arg Leu Val Ser Glu  Asp Pro Ile Asn Asp  Gly Glu Trp 
    4280                 4285                 4290             


His Arg  Val Thr Ala Leu Arg  Glu Gly Arg Arg Gly  Ser Ile Gln 
    4295                 4300                 4305             


Val Asp  Gly Glu Glu Leu Val  Ser Gly Arg Ser Pro  Gly Pro Asn 
    4310                 4315                 4320             


Val Ala  Val Asn Ala Lys Gly  Ser Val Tyr Ile Gly  Gly Ala Pro 
    4325                 4330                 4335             


Asp Val  Ala Thr Leu Thr Gly  Gly Arg Phe Ser Ser  Gly Ile Thr 
    4340                 4345                 4350             


Gly Cys  Val Lys Asn Leu Val  Leu His Ser Ala Arg  Pro Gly Ala 
    4355                 4360                 4365             


Pro Pro  Pro Gln Pro Leu Asp  Leu Gln His Arg Ala  Gln Ala Gly 
    4370                 4375                 4380             


Ala Asn  Thr Arg Pro Cys Pro  Ser 
    4385                 4390     


<210>  31
<211>  3410
<212>  PRT
<213>  Homo sapiens

<400>  31

Ile Phe Pro Pro Asn Cys Asn Lys Pro Pro Ser Lys Ala Lys Met Phe 
1               5                   10                  15      


Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile Val Thr 
            20                  25                  30          


His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly 
        35                  40                  45              


Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr Met Pro 
    50                  55                  60                  


Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile Lys Trp 
65                  70                  75                  80  


Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu Thr Thr 
                85                  90                  95      


Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp Tyr Lys 
            100                 105                 110         


Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp Ala Ser 
        115                 120                 125             


Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr Arg Cys 
    130                 135                 140                 


Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser Leu Thr 
145                 150                 155                 160 


Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg Tyr Thr 
                165                 170                 175     


Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly Ala Val 
            180                 185                 190         


Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu 
        195                 200                 205             


Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile 
    210                 215                 220                 


Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys Ala Gly 
225                 230                 235                 240 


Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp Val Tyr 
                245                 250                 255     


Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr Val Pro 
            260                 265                 270         


Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn Gln Asp 
        275                 280                 285             


Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly 
    290                 295                 300                 


Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His 
305                 310                 315                 320 


Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu Gly Val 
                325                 330                 335     


Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro Pro Asp 
            340                 345                 350         


Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Ala Thr Thr Ile 
        355                 360                 365             


Asp Leu Ser Ile Leu Ala Glu Thr Ala Ser Pro Ser Leu Ser Lys Glu 
    370                 375                 380                 


Pro Gln Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu Val Asp 
385                 390                 395                 400 


Glu Leu Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn Ile Val 
                405                 410                 415     


Ser Phe Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr Asp Ser 
            420                 425                 430         


Leu Ala Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys Pro Trp 
        435                 440                 445             


Asp Met Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly Lys Leu 
    450                 455                 460                 


Asp Ile Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr Gly Val 
465                 470                 475                 480 


Ser His Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp Lys Gln 
                485                 490                 495     


Thr Gln Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly Pro Leu 
            500                 505                 510         


Val Thr Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu Phe Pro 
        515                 520                 525             


Val Thr Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu Ser Lys 
    530                 535                 540                 


Thr Glu Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr Thr Gly 
545                 550                 555                 560 


His Tyr Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg Thr Leu 
                565                 570                 575     


Thr Val Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile Pro Glu 
            580                 585                 590         


Val Ile Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr His Leu 
        595                 600                 605             


Glu Asp Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro Leu Ile 
    610                 615                 620                 


Met Pro Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu Arg Gln 
625                 630                 635                 640 


Thr Ser Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu Ser Thr 
                645                 650                 655     


Thr Pro Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe Pro Tyr 
            660                 665                 670         


Ser Gly Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile Tyr Pro 
        675                 680                 685             


Ser Leu Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu Thr Leu 
    690                 695                 700                 


Ile Pro Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln Glu Glu 
705                 710                 715                 720 


Ile Thr Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val Phe Ser 
                725                 730                 735     


Gly Met Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val Thr Glu 
            740                 745                 750         


Ser Ser Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu Ile Thr 
        755                 760                 765             


Lys Leu Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu Asp Phe 
    770                 775                 780                 


Thr Ala Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr Thr Val 
785                 790                 795                 800 


Leu Leu Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val Ser Lys 
                805                 810                 815     


Trp Ser Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu Ser Thr 
            820                 825                 830         


Glu Pro Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr Thr Val 
        835                 840                 845             


Gly Met Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu Asp Gly 
    850                 855                 860                 


Ala Asp Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln Leu Glu 
865                 870                 875                 880 


Glu Val Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr Ile Arg 
                885                 890                 895     


Phe Gln Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr Leu Arg 
            900                 905                 910         


Asp Ser Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr Glu Gly 
        915                 920                 925             


Gln Val Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val Glu Asp 
    930                 935                 940                 


Val Asp Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala His Thr 
945                 950                 955                 960 


Ser Glu Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr Gln Glu 
                965                 970                 975     


Pro Thr Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser Val Ile 
            980                 985                 990         


Pro Lys Thr Asp Trp Gly Val Leu  Val Pro Ser Val Pro  Ser Glu Asp 
        995                 1000                 1005             


Glu Val  Leu Gly Glu Pro Ser  Gln Asp Ile Leu Val  Ile Asp Gln 
    1010                 1015                 1020             


Thr Arg  Leu Glu Ala Thr Ile  Ser Pro Glu Thr Met  Arg Thr Thr 
    1025                 1030                 1035             


Lys Ile  Thr Glu Gly Thr Thr  Gln Glu Glu Phe Pro  Trp Lys Glu 
    1040                 1045                 1050             


Gln Thr  Ala Glu Lys Pro Val  Pro Ala Leu Ser Ser  Thr Ala Trp 
    1055                 1060                 1065             


Thr Pro  Lys Glu Ala Val Thr  Pro Leu Asp Glu Gln  Glu Gly Asp 
    1070                 1075                 1080             


Gly Ser  Ala Tyr Thr Val Ser  Glu Asp Glu Leu Leu  Thr Gly Ser 
    1085                 1090                 1095             


Glu Arg  Val Pro Val Leu Glu  Thr Thr Pro Val Gly  Lys Ile Asp 
    1100                 1105                 1110             


His Ser  Val Ser Tyr Pro Pro  Gly Ala Val Thr Glu  His Lys Val 
    1115                 1120                 1125             


Lys Thr  Asp Glu Val Val Thr  Leu Thr Pro Arg Ile  Gly Pro Lys 
    1130                 1135                 1140             


Val Ser  Leu Ser Pro Gly Pro  Glu Gln Lys Tyr Glu  Thr Glu Gly 
    1145                 1150                 1155             


Ser Ser  Thr Thr Gly Phe Thr  Ser Ser Leu Ser Pro  Phe Ser Thr 
    1160                 1165                 1170             


His Ile  Thr Gln Leu Met Glu  Glu Thr Thr Thr Glu  Lys Thr Ser 
    1175                 1180                 1185             


Leu Glu  Asp Ile Asp Leu Gly  Ser Gly Leu Phe Glu  Lys Pro Lys 
    1190                 1195                 1200             


Ala Thr  Glu Leu Ile Glu Phe  Ser Thr Ile Lys Val  Thr Val Pro 
    1205                 1210                 1215             


Ser Asp  Ile Thr Thr Ala Phe  Ser Ser Val Asp Arg  Leu His Thr 
    1220                 1225                 1230             


Thr Ser  Ala Phe Lys Pro Ser  Ser Ala Ile Thr Lys  Lys Pro Pro 
    1235                 1240                 1245             


Leu Ile  Asp Arg Glu Pro Gly  Glu Glu Thr Thr Ser  Asp Met Val 
    1250                 1255                 1260             


Ile Ile  Gly Glu Ser Thr Ser  His Val Pro Pro Thr  Thr Leu Glu 
    1265                 1270                 1275             


Asp Ile  Val Ala Lys Glu Thr  Glu Thr Asp Ile Asp  Arg Glu Tyr 
    1280                 1285                 1290             


Phe Thr  Thr Ser Ser Pro Pro  Ala Thr Gln Pro Thr  Arg Pro Pro 
    1295                 1300                 1305             


Thr Val  Glu Asp Lys Glu Ala  Phe Gly Pro Gln Ala  Leu Ser Thr 
    1310                 1315                 1320             


Pro Gln  Pro Pro Ala Ser Thr  Lys Phe His Pro Asp  Ile Asn Val 
    1325                 1330                 1335             


Tyr Ile  Ile Glu Val Arg Glu  Asn Lys Thr Gly Arg  Met Ser Asp 
    1340                 1345                 1350             


Leu Ser  Val Ile Gly His Pro  Ile Asp Ser Glu Ser  Lys Glu Asp 
    1355                 1360                 1365             


Glu Pro  Cys Ser Glu Glu Thr  Asp Pro Val His Asp  Leu Met Ala 
    1370                 1375                 1380             


Glu Ile  Leu Pro Glu Phe Pro  Asp Ile Ile Glu Ile  Asp Leu Tyr 
    1385                 1390                 1395             


His Ser  Glu Glu Asn Glu Glu  Glu Glu Glu Glu Cys  Ala Asn Ala 
    1400                 1405                 1410             


Thr Asp  Val Thr Thr Thr Pro  Ser Val Gln Tyr Ile  Asn Gly Lys 
    1415                 1420                 1425             


His Leu  Val Thr Thr Val Pro  Lys Asp Pro Glu Ala  Ala Glu Ala 
    1430                 1435                 1440             


Arg Arg  Gly Gln Phe Glu Ser  Val Ala Pro Ser Gln  Asn Phe Ser 
    1445                 1450                 1455             


Asp Ser  Ser Glu Ser Asp Thr  His Pro Phe Val Ile  Ala Lys Thr 
    1460                 1465                 1470             


Glu Leu  Ser Thr Ala Val Gln  Pro Asn Glu Ser Thr  Glu Thr Thr 
    1475                 1480                 1485             


Glu Ser  Leu Glu Val Thr Trp  Lys Pro Glu Thr Tyr  Pro Glu Thr 
    1490                 1495                 1500             


Ser Glu  His Phe Ser Gly Gly  Glu Pro Asp Val Phe  Pro Thr Val 
    1505                 1510                 1515             


Pro Phe  His Glu Glu Phe Glu  Ser Gly Thr Ala Lys  Lys Gly Ala 
    1520                 1525                 1530             


Glu Ser  Val Thr Glu Arg Asp  Thr Glu Val Gly His  Gln Ala His 
    1535                 1540                 1545             


Glu His  Thr Glu Pro Val Ser  Leu Phe Pro Glu Glu  Ser Ser Gly 
    1550                 1555                 1560             


Glu Ile  Ala Ile Asp Gln Glu  Ser Gln Lys Ile Ala  Phe Ala Arg 
    1565                 1570                 1575             


Ala Thr  Glu Val Thr Phe Gly  Glu Glu Val Glu Lys  Ser Thr Ser 
    1580                 1585                 1590             


Val Thr  Tyr Thr Pro Thr Ile  Val Pro Ser Ser Ala  Ser Ala Tyr 
    1595                 1600                 1605             


Val Ser  Glu Glu Glu Ala Val  Thr Leu Ile Gly Asn  Pro Trp Pro 
    1610                 1615                 1620             


Asp Asp  Leu Leu Ser Thr Lys  Glu Ser Trp Val Glu  Ala Thr Pro 
    1625                 1630                 1635             


Arg Gln  Val Val Glu Leu Ser  Gly Ser Ser Ser Ile  Pro Ile Thr 
    1640                 1645                 1650             


Glu Gly  Ser Gly Glu Ala Glu  Glu Asp Glu Asp Thr  Met Phe Thr 
    1655                 1660                 1665             


Met Val  Thr Asp Leu Ser Gln  Arg Asn Thr Thr Asp  Thr Leu Ile 
    1670                 1675                 1680             


Thr Leu  Asp Thr Ser Arg Ile  Ile Thr Glu Ser Phe  Phe Glu Val 
    1685                 1690                 1695             


Pro Ala  Thr Thr Ile Tyr Pro  Val Ser Glu Gln Pro  Ser Ala Lys 
    1700                 1705                 1710             


Val Val  Pro Thr Lys Phe Val  Ser Glu Thr Asp Thr  Ser Glu Trp 
    1715                 1720                 1725             


Ile Ser  Ser Thr Thr Val Glu  Glu Lys Lys Arg Lys  Glu Glu Glu 
    1730                 1735                 1740             


Gly Thr  Thr Gly Thr Ala Ser  Thr Phe Glu Val Tyr  Ser Ser Thr 
    1745                 1750                 1755             


Gln Arg  Ser Asp Gln Leu Ile  Leu Pro Phe Glu Leu  Glu Ser Pro 
    1760                 1765                 1770             


Asn Val  Ala Thr Ser Ser Asp  Ser Gly Thr Arg Lys  Ser Phe Met 
    1775                 1780                 1785             


Ser Leu  Thr Thr Pro Thr Gln  Ser Glu Arg Glu Met  Thr Asp Ser 
    1790                 1795                 1800             


Thr Pro  Val Phe Thr Glu Thr  Asn Thr Leu Glu Asn  Leu Gly Ala 
    1805                 1810                 1815             


Gln Thr  Thr Glu His Ser Ser  Ile His Gln Pro Gly  Val Gln Glu 
    1820                 1825                 1830             


Gly Leu  Thr Thr Leu Pro Arg  Ser Pro Ala Ser Val  Phe Met Glu 
    1835                 1840                 1845             


Gln Gly  Ser Gly Glu Ala Ala  Ala Asp Pro Glu Thr  Thr Thr Val 
    1850                 1855                 1860             


Ser Ser  Phe Ser Leu Asn Val  Glu Tyr Ala Ile Gln  Ala Glu Lys 
    1865                 1870                 1875             


Glu Val  Ala Gly Thr Leu Ser  Pro His Val Glu Thr  Thr Phe Ser 
    1880                 1885                 1890             


Thr Glu  Pro Thr Gly Leu Val  Leu Ser Thr Val Met  Asp Arg Val 
    1895                 1900                 1905             


Val Ala  Glu Asn Ile Thr Gln  Thr Ser Arg Glu Ile  Val Ile Ser 
    1910                 1915                 1920             


Glu Arg  Leu Gly Glu Pro Asn  Tyr Gly Ala Glu Ile  Arg Gly Phe 
    1925                 1930                 1935             


Ser Thr  Gly Phe Pro Leu Glu  Glu Asp Phe Ser Gly  Asp Phe Arg 
    1940                 1945                 1950             


Glu Tyr  Ser Thr Val Ser His  Pro Ile Ala Lys Glu  Glu Thr Val 
    1955                 1960                 1965             


Met Met  Glu Gly Ser Gly Asp  Ala Ala Phe Arg Asp  Thr Gln Thr 
    1970                 1975                 1980             


Ser Pro  Ser Thr Val Pro Thr  Ser Val His Ile Ser  His Ile Ser 
    1985                 1990                 1995             


Asp Ser  Glu Gly Pro Ser Ser  Thr Met Val Ser Thr  Ser Ala Phe 
    2000                 2005                 2010             


Pro Trp  Glu Glu Phe Thr Ser  Ser Ala Glu Gly Ser  Gly Glu Gln 
    2015                 2020                 2025             


Leu Val  Thr Val Ser Ser Ser  Val Val Pro Val Leu  Pro Ser Ala 
    2030                 2035                 2040             


Val Gln  Lys Phe Ser Gly Thr  Ala Ser Ser Ile Ile  Asp Glu Gly 
    2045                 2050                 2055             


Leu Gly  Glu Val Gly Thr Val  Asn Glu Ile Asp Arg  Arg Ser Thr 
    2060                 2065                 2070             


Ile Leu  Pro Thr Ala Glu Val  Glu Gly Thr Lys Ala  Pro Val Glu 
    2075                 2080                 2085             


Lys Glu  Glu Val Lys Val Ser  Gly Thr Val Ser Thr  Asn Phe Pro 
    2090                 2095                 2100             


Gln Thr  Ile Glu Pro Ala Lys  Leu Trp Ser Arg Gln  Glu Val Asn 
    2105                 2110                 2115             


Pro Val  Arg Gln Glu Ile Glu  Ser Glu Thr Thr Ser  Glu Glu Gln 
    2120                 2125                 2130             


Ile Gln  Glu Glu Lys Ser Phe  Glu Ser Pro Gln Asn  Ser Pro Ala 
    2135                 2140                 2145             


Thr Glu  Gln Thr Ile Phe Asp  Ser Gln Thr Phe Thr  Glu Thr Glu 
    2150                 2155                 2160             


Leu Lys  Thr Thr Asp Tyr Ser  Val Leu Thr Thr Lys  Lys Thr Tyr 
    2165                 2170                 2175             


Ser Asp  Asp Lys Glu Met Lys  Glu Glu Asp Thr Ser  Leu Val Asn 
    2180                 2185                 2190             


Met Ser  Thr Pro Asp Pro Asp  Ala Asn Gly Leu Glu  Ser Tyr Thr 
    2195                 2200                 2205             


Thr Leu  Pro Glu Ala Thr Glu  Lys Ser His Phe Phe  Leu Ala Thr 
    2210                 2215                 2220             


Ala Leu  Val Thr Glu Ser Ile  Pro Ala Glu His Val  Val Thr Asp 
    2225                 2230                 2235             


Ser Pro  Ile Lys Lys Glu Glu  Ser Thr Lys His Phe  Pro Lys Gly 
    2240                 2245                 2250             


Met Arg  Pro Thr Ile Gln Glu  Ser Asp Thr Glu Leu  Leu Phe Ser 
    2255                 2260                 2265             


Gly Leu  Gly Ser Gly Glu Glu  Val Leu Pro Thr Leu  Pro Thr Glu 
    2270                 2275                 2280             


Ser Val  Asn Phe Thr Glu Val  Glu Gln Ile Asn Asn  Thr Leu Tyr 
    2285                 2290                 2295             


Pro His  Thr Ser Gln Val Glu  Ser Thr Ser Ser Asp  Lys Ile Glu 
    2300                 2305                 2310             


Asp Phe  Asn Arg Met Glu Asn  Val Ala Lys Glu Val  Gly Pro Leu 
    2315                 2320                 2325             


Val Ser  Gln Thr Asp Ile Phe  Glu Gly Ser Gly Ser  Val Thr Ser 
    2330                 2335                 2340             


Thr Thr  Leu Ile Glu Ile Leu  Ser Asp Thr Gly Ala  Glu Gly Pro 
    2345                 2350                 2355             


Thr Val  Ala Pro Leu Pro Phe  Ser Thr Asp Ile Gly  His Pro Gln 
    2360                 2365                 2370             


Asn Gln  Thr Val Arg Trp Ala  Glu Glu Ile Gln Thr  Ser Arg Pro 
    2375                 2380                 2385             


Gln Thr  Ile Thr Glu Gln Asp  Ser Asn Lys Asn Ser  Ser Thr Ala 
    2390                 2395                 2400             


Glu Ile  Asn Glu Thr Thr Thr  Ser Ser Thr Asp Phe  Leu Ala Arg 
    2405                 2410                 2415             


Ala Tyr  Gly Phe Glu Met Ala  Lys Glu Phe Val Thr  Ser Ala Pro 
    2420                 2425                 2430             


Lys Pro  Ser Asp Leu Tyr Tyr  Glu Pro Ser Gly Glu  Gly Ser Gly 
    2435                 2440                 2445             


Glu Val  Asp Ile Val Asp Ser  Phe His Thr Ser Ala  Thr Thr Gln 
    2450                 2455                 2460             


Ala Thr  Arg Gln Glu Ser Ser  Thr Thr Phe Val Ser  Asp Gly Ser 
    2465                 2470                 2475             


Leu Glu  Lys His Pro Glu Val  Pro Ser Ala Lys Ala  Val Thr Ala 
    2480                 2485                 2490             


Asp Gly  Phe Pro Thr Val Leu  Val Met Leu Pro Leu  His Ser Glu 
    2495                 2500                 2505             


Gln Asn  Lys Ser Ser Pro Asp  Pro Thr Ser Thr Leu  Ser Asn Thr 
    2510                 2515                 2520             


Val Ser  Tyr Glu Arg Ser Thr  Asp Gly Ser Phe Gln  Asp Arg Phe 
    2525                 2530                 2535             


Arg Glu  Phe Glu Asp Ser Thr  Leu Lys Pro Asn Arg  Lys Lys Pro 
    2540                 2545                 2550             


Thr Glu  Asn Ile Ile Ile Asp  Leu Asp Lys Glu Asp  Lys Asp Leu 
    2555                 2560                 2565             


Ile Leu  Thr Ile Thr Glu Ser  Thr Ile Leu Glu Ile  Leu Pro Glu 
    2570                 2575                 2580             


Leu Thr  Ser Asp Lys Asn Thr  Ile Ile Asp Ile Asp  His Thr Lys 
    2585                 2590                 2595             


Pro Val  Tyr Glu Asp Ile Leu  Gly Met Gln Thr Asp  Ile Asp Thr 
    2600                 2605                 2610             


Glu Val  Pro Ser Glu Pro His  Asp Ser Asn Asp Glu  Ser Asn Asp 
    2615                 2620                 2625             


Asp Ser  Thr Gln Val Gln Glu  Ile Tyr Glu Ala Ala  Val Asn Leu 
    2630                 2635                 2640             


Ser Leu  Thr Glu Glu Thr Phe  Glu Gly Ser Ala Asp  Val Leu Ala 
    2645                 2650                 2655             


Ser Tyr  Thr Gln Ala Thr His  Asp Glu Ser Met Thr  Tyr Glu Asp 
    2660                 2665                 2670             


Arg Ser  Gln Leu Asp His Met  Gly Phe His Phe Thr  Thr Gly Ile 
    2675                 2680                 2685             


Pro Ala  Pro Ser Thr Glu Thr  Glu Leu Asp Val Leu  Leu Pro Thr 
    2690                 2695                 2700             


Ala Thr  Ser Leu Pro Ile Pro  Arg Lys Ser Ala Thr  Val Ile Pro 
    2705                 2710                 2715             


Glu Ile  Glu Gly Ile Lys Ala  Glu Ala Lys Ala Leu  Asp Asp Met 
    2720                 2725                 2730             


Phe Glu  Ser Ser Thr Leu Ser  Asp Gly Gln Ala Ile  Ala Asp Gln 
    2735                 2740                 2745             


Ser Glu  Ile Ile Pro Thr Leu  Gly Gln Phe Glu Arg  Thr Gln Glu 
    2750                 2755                 2760             


Glu Tyr  Glu Asp Lys Lys His  Ala Gly Pro Ser Phe  Gln Pro Glu 
    2765                 2770                 2775             


Phe Ser  Ser Gly Ala Glu Glu  Ala Leu Val Asp His  Thr Pro Tyr 
    2780                 2785                 2790             


Leu Ser  Ile Ala Thr Thr His  Leu Met Asp Gln Ser  Val Thr Glu 
    2795                 2800                 2805             


Val Pro  Asp Val Met Glu Gly  Ser Asn Pro Pro Tyr  Tyr Thr Asp 
    2810                 2815                 2820             


Thr Thr  Leu Ala Val Ser Thr  Phe Ala Lys Leu Ser  Ser Gln Thr 
    2825                 2830                 2835             


Pro Ser  Ser Pro Leu Thr Ile  Tyr Ser Gly Ser Glu  Ala Ser Gly 
    2840                 2845                 2850             


His Thr  Glu Ile Pro Gln Pro  Ser Ala Leu Pro Gly  Ile Asp Val 
    2855                 2860                 2865             


Gly Ser  Ser Val Met Ser Pro  Gln Asp Ser Phe Lys  Glu Ile His 
    2870                 2875                 2880             


Val Asn  Ile Glu Ala Thr Phe  Lys Pro Ser Ser Glu  Glu Tyr Leu 
    2885                 2890                 2895             


His Ile  Thr Glu Pro Pro Ser  Leu Ser Pro Asp Thr  Lys Leu Glu 
    2900                 2905                 2910             


Pro Ser  Glu Asp Asp Gly Lys  Pro Glu Leu Leu Glu  Glu Met Glu 
    2915                 2920                 2925             


Ala Ser  Pro Thr Glu Leu Ile  Ala Val Glu Gly Thr  Glu Ile Leu 
    2930                 2935                 2940             


Gln Asp  Phe Gln Asn Lys Thr  Asp Gly Gln Val Ser  Gly Glu Ala 
    2945                 2950                 2955             


Ile Lys  Met Phe Pro Thr Ile  Lys Thr Pro Glu Ala  Gly Thr Val 
    2960                 2965                 2970             


Ile Thr  Thr Ala Asp Glu Ile  Glu Leu Glu Gly Ala  Thr Gln Trp 
    2975                 2980                 2985             


Pro His  Ser Thr Ser Ala Ser  Ala Thr Tyr Gly Val  Glu Ala Gly 
    2990                 2995                 3000             


Val Val  Pro Trp Leu Ser Pro  Gln Thr Ser Glu Arg  Pro Thr Leu 
    3005                 3010                 3015             


Ser Ser  Ser Pro Glu Ile Asn  Pro Glu Thr Gln Ala  Ala Leu Ile 
    3020                 3025                 3030             


Arg Gly  Gln Asp Ser Thr Ile  Ala Ala Ser Glu Gln  Gln Val Ala 
    3035                 3040                 3045             


Ala Arg  Ile Leu Asp Ser Asn  Asp Gln Ala Thr Val  Asn Pro Val 
    3050                 3055                 3060             


Glu Phe  Asn Thr Glu Val Ala  Thr Pro Pro Phe Ser  Leu Leu Glu 
    3065                 3070                 3075             


Thr Ser  Asn Glu Thr Asp Phe  Leu Ile Gly Ile Asn  Glu Glu Ser 
    3080                 3085                 3090             


Val Glu  Gly Thr Ala Ile Tyr  Leu Pro Gly Pro Asp  Arg Cys Lys 
    3095                 3100                 3105             


Met Asn  Pro Cys Leu Asn Gly  Gly Thr Cys Tyr Pro  Thr Glu Thr 
    3110                 3115                 3120             


Ser Tyr  Val Cys Thr Cys Val  Pro Gly Tyr Ser Gly  Asp Gln Cys 
    3125                 3130                 3135             


Glu Leu  Asp Phe Asp Glu Cys  His Ser Asn Pro Cys  Arg Asn Gly 
    3140                 3145                 3150             


Ala Thr  Cys Val Asp Gly Phe  Asn Thr Phe Arg Cys  Leu Cys Leu 
    3155                 3160                 3165             


Pro Ser  Tyr Val Gly Ala Leu  Cys Glu Gln Asp Thr  Glu Thr Cys 
    3170                 3175                 3180             


Asp Tyr  Gly Trp His Lys Phe  Gln Gly Gln Cys Tyr  Lys Tyr Phe 
    3185                 3190                 3195             


Ala His  Arg Arg Thr Trp Asp  Ala Ala Glu Arg Glu  Cys Arg Leu 
    3200                 3205                 3210             


Gln Gly  Ala His Leu Thr Ser  Ile Leu Ser His Glu  Glu Gln Met 
    3215                 3220                 3225             


Phe Val  Asn Arg Val Gly His  Asp Tyr Gln Trp Ile  Gly Leu Asn 
    3230                 3235                 3240             


Asp Lys  Met Phe Glu His Asp  Phe Arg Trp Thr Asp  Gly Ser Thr 
    3245                 3250                 3255             


Leu Gln  Tyr Glu Asn Trp Arg  Pro Asn Gln Pro Asp  Ser Phe Phe 
    3260                 3265                 3270             


Ser Ala  Gly Glu Asp Cys Val  Val Ile Ile Trp His  Glu Asn Gly 
    3275                 3280                 3285             


Gln Trp  Asn Asp Val Pro Cys  Asn Tyr His Leu Thr  Tyr Thr Cys 
    3290                 3295                 3300             


Lys Lys  Gly Thr Val Ala Cys  Gly Gln Pro Pro Val  Val Glu Asn 
    3305                 3310                 3315             


Ala Lys  Thr Phe Gly Lys Met  Lys Pro Arg Tyr Glu  Ile Asn Ser 
    3320                 3325                 3330             


Leu Ile  Arg Tyr His Cys Lys  Asp Gly Phe Ile Gln  Arg His Leu 
    3335                 3340                 3345             


Pro Thr  Ile Arg Cys Leu Gly  Asn Gly Arg Trp Ala  Ile Pro Lys 
    3350                 3355                 3360             


Ile Thr  Cys Met Asn Pro Ser  Ala Tyr Gln Arg Thr  Tyr Ser Met 
    3365                 3370                 3375             


Lys Tyr  Phe Lys Asn Ser Ser  Ser Ala Lys Asp Asn  Ser Ile Asn 
    3380                 3385                 3390             


Thr Ser  Lys His Asp His Arg  Trp Ser Arg Arg Trp  Gln Glu Ser 
    3395                 3400                 3405             


Arg Arg  
    3410 


<210>  32
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ser Pro Gly Cys Leu Leu Cys Val Leu Gly Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ala Ala Ser Leu Glu Leu Ser Arg Pro His Gly Asp Thr Ala Lys 
            20                  25                  30          


Lys Pro Ile Ile Gly Ile Leu Met Gln Lys Cys Arg Asn Lys Val Met 
        35                  40                  45              


Lys Asn Tyr Gly Arg Tyr Tyr Ile Ala Ala Ser Tyr Val Lys Tyr Leu 
    50                  55                  60                  


Glu Ser Ala Gly Ala Arg Val Val Pro Val Arg Leu Asp Leu Thr Glu 
65                  70                  75                  80  


Lys Asp Tyr Glu Ile Leu Phe Lys Ser Ile Asn Gly Ile Leu Phe Pro 
                85                  90                  95      


Gly Gly Ser Val Asp Leu Arg Arg Ser Asp Tyr Ala Lys Val Ala Lys 
            100                 105                 110         


Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr Phe 
        115                 120                 125             


Pro Val Trp Gly Thr Cys Leu Gly Phe Glu Glu Leu Ser Leu Leu Ile 
    130                 135                 140                 


Ser Gly Glu Cys Leu Leu Thr Ala Thr Asp Thr Val Asp Val Ala Met 
145                 150                 155                 160 


Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser Arg Met Phe Gln Asn 
                165                 170                 175     


Phe Pro Thr Glu Leu Leu Leu Ser Leu Ala Val Glu Pro Leu Thr Ala 
            180                 185                 190         


Asn Phe His Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu 
        195                 200                 205             


Lys Leu Lys Lys Phe Phe Asn Val Leu Thr Thr Asn Thr Asp Gly Lys 
    210                 215                 220                 


Ile Glu Phe Ile Ser Thr Met Glu Gly Tyr Lys Tyr Pro Val Tyr Gly 
225                 230                 235                 240 


Val Gln Trp His Pro Glu Lys Ala Pro Tyr Glu Trp Lys Asn Leu Asp 
                245                 250                 255     


Gly Ile Ser His Ala Pro Asn Ala Val Lys Thr Ala Phe Tyr Leu Ala 
            260                 265                 270         


Glu Phe Phe Val Asn Glu Ala Arg Lys Asn Asn His His Phe Lys Ser 
        275                 280                 285             


Glu Ser Glu Glu Glu Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Ile Ser Ser Phe Gln Gln Cys Tyr Ile Phe Asp 
305                 310                 315             


<210>  33
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys 
    50                  55                  60                  


Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp 
65                  70                  75                  80  


Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val 
                85                  90                  95      


Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser Ser 
            100                 105                 110         


Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His Cys 
        115                 120                 125             


Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly Trp Gly 
    130                 135                 140                 


Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys Ser Asp 
145                 150                 155                 160 


Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn Gln Ile 
                165                 170                 175     


Glu Asn Leu Asn Ile Gln Val Glu Asp Ile Arg Ile Arg Ala Ile Leu 
            180                 185                 190         


Ser Thr Tyr Arg Lys Arg Thr Pro Val Met Glu Gly Tyr Val Glu Val 
        195                 200                 205             


Lys Glu Gly Lys Thr Trp Lys Gln Ile Cys Asp Lys His Trp Thr Ala 
    210                 215                 220                 


Lys Asn Ser Arg Val Val Cys Gly Met Phe Gly Phe Pro Gly Glu Arg 
225                 230                 235                 240 


Thr Tyr Asn Thr Lys Val Tyr Lys Met Phe Ala Ser Arg Arg Lys Gln 
                245                 250                 255     


Arg Tyr Trp Pro Phe Ser Met Asp Cys Thr Gly Thr Glu Ala His Ile 
            260                 265                 270         


Ser Ser Cys Lys Leu Gly Pro Gln Val Ser Leu Asp Pro Met Lys Asn 
        275                 280                 285             


Val Thr Cys Glu Asn Gly Leu Pro Ala Val Val Ser Cys Val Pro Gly 
    290                 295                 300                 


Gln Val Phe Ser Pro Asp Gly Pro Ser Arg Phe Arg Lys Ala Tyr Lys 
305                 310                 315                 320 


Pro Glu Gln Pro Leu Val Arg Leu Arg Gly Gly Ala Tyr Ile Gly Glu 
                325                 330                 335     


Gly Arg Val Glu Val Leu Lys Asn Gly Glu Trp Gly Thr Val Cys Asp 
            340                 345                 350         


Asp Lys Trp Asp Leu Val Ser Ala Ser Val Val Cys Arg Glu Leu Gly 
        355                 360                 365             


Phe Gly Ser Ala Lys Glu Ala Val Thr Gly Ser Arg Leu Gly Gln Gly 
    370                 375                 380                 


Ile Gly Pro Ile His Leu Asn Glu Ile Gln Cys Thr Gly Asn Glu Lys 
385                 390                 395                 400 


Ser Ile Ile Asp Cys Lys Phe Asn Ala Glu Ser Gln Gly Cys Asn His 
                405                 410                 415     


Glu Glu Asp Ala Gly Val Arg Cys Asn Thr Pro Ala Met Gly Leu Gln 
            420                 425                 430         


Lys Lys Leu Arg Leu Asn Gly Gly Arg Asn Pro Tyr Glu Gly Arg Val 
        435                 440                 445             


Glu Val Leu Val Glu Arg Asn Gly Ser Leu Val Trp Gly Met Val Cys 
    450                 455                 460                 


Gly Gln Asn Trp Gly Ile Val Glu Ala Met Val Val Cys Arg Gln Leu 
465                 470                 475                 480 


Gly Leu Gly Phe Ala Ser Asn Ala Phe Gln Glu Thr Trp Tyr Trp His 
                485                 490                 495     


Gly Asp Val Asn Ser Asn Lys Val Val Met Ser Gly Val Lys Cys Ser 
            500                 505                 510         


Gly Thr Glu Leu Ser Leu Ala His Cys Arg His Asp Gly Glu Asp Val 
        515                 520                 525             


Ala Cys Pro Gln Gly Gly Val Gln Tyr Gly Ala Gly Val Ala Cys Ser 
    530                 535                 540                 


Glu Thr Ala Pro Asp Leu Val Leu Asn Ala Glu Met Val Gln Gln Thr 
545                 550                 555                 560 


Thr Tyr Leu Glu Asp Arg Pro Met Phe Met Leu Gln Cys Ala Met Glu 
                565                 570                 575     


Glu Asn Cys Leu Ser Ala Ser Ala Ala Gln Thr Asp Pro Thr Thr Gly 
            580                 585                 590         


Tyr Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln 
        595                 600                 605             


Ser Asp Phe Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp 
    610                 615                 620                 


Cys His Arg His Tyr His Ser Met Glu Val Phe Thr His Tyr Asp Leu 
625                 630                 635                 640 


Leu Asn Leu Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe 
                645                 650                 655     


Cys Leu Glu Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu 
            660                 665                 670         


Cys Ala Asn Phe Gly Asp Gln Gly Ile Thr Met Gly Cys Trp Asp Met 
        675                 680                 685             


Tyr Arg His Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Pro 
    690                 695                 700                 


Pro Gly Asp Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Phe Glu Val 
705                 710                 715                 720 


Ala Glu Ser Asp Tyr Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr 
                725                 730                 735     


Asp Gly His Arg Ile Trp Met Tyr Asn Cys His Ile Gly Gly Ser Phe 
            740                 745                 750         


Ser Glu Glu Thr Glu Lys Lys Phe Glu His Phe Ser Gly Leu Leu Asn 
        755                 760                 765             


Asn Gln Leu Ser Pro Gln 
    770                 


<210>  34
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe 
145                 150                 155                 160 


Ala Val Phe Leu Ile Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro 
            180                 185                 190         


Thr Asn Glu Phe Tyr Ala 
        195             


<210>  35
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 
        195                 200                 205             


Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 
    210                 215                 220                 


Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 
                245                 250                 255     


Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 
            260                 265                 270         


Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 
        275                 280                 285             


Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly 
    290                 295                 300                 


Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 
305                 310                 315                 320 


Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 
                325                 330                 335     


Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 
            340                 345                 350         


Tyr 
    


<210>  36
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Glu His Leu Glu Gly Val Ile Asn Lys Pro Glu Ala Glu Met Ser 
1               5                   10                  15      


Pro Gln Glu Leu Gln Leu His Tyr Phe Lys Met His Asp Tyr Asp Gly 
            20                  25                  30          


Asn Asn Leu Leu Asp Gly Leu Glu Leu Ser Thr Ala Ile Thr His Val 
        35                  40                  45              


His Lys Glu Glu Gly Ser Glu Gln Ala Pro Leu Met Ser Glu Asp Glu 
    50                  55                  60                  


Leu Ile Asn Ile Ile Asp Gly Val Leu Arg Asp Asp Asp Lys Asn Asn 
65                  70                  75                  80  


Asp Gly Tyr Ile Asp Tyr Ala Glu Phe Ala Lys Ser Leu Gln 
                85                  90                  


<210>  37
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala Glu Pro Val Gln Phe Arg Asp Cys Gly Ser Val Asp Gly 
            20                  25                  30          


Val Ile Lys Glu Val Asn Val Ser Pro Cys Pro Thr Gln Pro Cys Gln 
        35                  40                  45              


Leu Ser Lys Gly Gln Ser Tyr Ser Val Asn Val Thr Phe Thr Ser Asn 
    50                  55                  60                  


Val Gln Ser Lys Ser Ser Lys Ala Val Val His Gly Ile Leu Met Gly 
65                  70                  75                  80  


Val Pro Val Pro Phe Pro Ile Pro Glu Pro Asp Gly Cys Lys Ser Gly 
                85                  90                  95      


Ile Asn Cys Pro Ile Gln Lys Asp Lys Thr Tyr Ser Tyr Leu Asn Lys 
            100                 105                 110         


Leu Pro Val Lys Ser Glu Tyr Pro Ser Ile Lys Leu Val Val Glu Trp 
        115                 120                 125             


Gln Leu Gln Asp Asp Lys Asn Gln Ser Leu Phe Cys Trp Glu Ile Pro 
    130                 135                 140                 


Val Gln Ile Val Ser His Leu 
145                 150     


<210>  38
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Asp Arg Glu Asp Leu Val Tyr Gln Ala Lys Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Glu Met Val Glu Ser Met Lys Lys Val Ala Gly 
            20                  25                  30          


Met Asp Val Glu Leu Thr Val Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Ile Gly Ala Arg Arg Ala Ser Trp Arg Ile Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Glu Glu Asn Lys Gly Gly Glu Asp Lys Leu Lys 
65                  70                  75                  80  


Met Ile Arg Glu Tyr Arg Gln Met Val Glu Thr Glu Leu Lys Leu Ile 
                85                  90                  95      


Cys Cys Asp Ile Leu Asp Val Leu Asp Lys His Leu Ile Pro Ala Ala 
            100                 105                 110         


Asn Thr Gly Glu Ser Lys Val Phe Tyr Tyr Lys Met Lys Gly Asp Tyr 
        115                 120                 125             


His Arg Tyr Leu Ala Glu Phe Ala Thr Gly Asn Asp Arg Lys Glu Ala 
    130                 135                 140                 


Ala Glu Asn Ser Leu Val Ala Tyr Lys Ala Ala Ser Asp Ile Ala Met 
145                 150                 155                 160 


Thr Glu Leu Pro Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn 
                165                 170                 175     


Phe Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Asp Arg Ala Cys 
            180                 185                 190         


Arg Leu Ala Lys Ala Ala Phe Asp Asp Ala Ile Ala Glu Leu Asp Thr 
        195                 200                 205             


Leu Ser Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu 
    210                 215                 220                 


Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Met Gln Gly Asp Gly Glu 
225                 230                 235                 240 


Glu Gln Asn Lys Glu Ala Leu Gln Asp Val Glu Asp Glu Asn Gln 
                245                 250                 255 


<210>  39
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Arg Tyr Val Ala Ser Tyr Leu Leu Ala Ala Leu Gly Gly Asn Ser 
1               5                   10                  15      


Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Ser Val Gly Ile 
            20                  25                  30          


Glu Ala Asp Asp Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn Gly 
        35                  40                  45              


Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile Gly Lys Leu Ala Ser 
    50                  55                  60                  


Val Pro Ala Gly Gly Ala Val Ala Val Ser Ala Ala Pro Gly Ser Ala 
65                  70                  75                  80  


Ala Pro Ala Ala Gly Ser Ala Pro Ala Ala Ala Glu Glu Lys Lys Asp 
                85                  90                  95      


Glu Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly 
            100                 105                 110         


Leu Phe Asp 
        115 


<210>  40
<211>  2045
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Val Pro His Thr  Val Leu Asn 
    1745                 1750                 1755             


Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1760                 1765                 1770             


Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly Phe Asp  Gly Ala Ile 
    1775                 1780                 1785             


Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu Leu Thr  Pro Glu His 
    1790                 1795                 1800             


Val Leu  Arg Gln Val Asp Val  Thr Ser Phe Ala Gly  His Pro Cys 
    1805                 1810                 1815             


Thr Arg  Ala Ser Gly His Pro  Cys Leu Asn Gly Ala  Ser Cys Val 
    1820                 1825                 1830             


Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1835                 1840                 1845             


Gly Pro  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Ala Gly Asp 
    1850                 1855                 1860             


Val Asp  Thr Leu Ala Phe Asp  Gly Arg Thr Phe Val  Glu Tyr Leu 
    1865                 1870                 1875             


Asn Ala  Val Thr Glu Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1880                 1885                 1890             


Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln Gly Leu  Val Leu Trp 
    1895                 1900                 1905             


Ser Gly  Lys Ala Thr Glu Arg  Ala Asp Tyr Val Ala  Leu Ala Ile 
    1910                 1915                 1920             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn Leu Gly  Ser Gln Pro 
    1925                 1930                 1935             


Val Val  Leu Arg Ser Thr Val  Pro Val Asn Thr Asn  Arg Trp Leu 
    1940                 1945                 1950             


Arg Val  Val Ala His Arg Glu  Gln Arg Glu Gly Ser  Leu Gln Val 
    1955                 1960                 1965             


Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser Pro Leu  Gly Ala Thr 
    1970                 1975                 1980             


Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Pro Glu 
    1985                 1990                 1995             


Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala Tyr Gly  Thr Gly Phe 
    2000                 2005                 2010             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly Arg His  Pro Leu His 
    2015                 2020                 2025             


Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu Leu Arg  Pro Cys Pro 
    2030                 2035                 2040             


Thr Pro  
    2045 


<210>  41
<211>  892
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Asp His Tyr Asp Ser Gln Gln Thr Asn Asp Tyr Met Gln Pro Glu 
1               5                   10                  15      


Glu Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln 
            20                  25                  30          


Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala 
        35                  40                  45              


Gly Thr Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asp Gly Leu Lys 
    50                  55                  60                  


Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Ala Lys Pro 
65                  70                  75                  80  


Glu Arg Gly Lys Met Arg Val His Lys Ile Ser Asn Val Asn Lys Ala 
                85                  90                  95      


Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala 
            100                 105                 110         


Glu Glu Ile Val Asp Gly Asn Val Lys Met Thr Leu Gly Met Ile Trp 
        115                 120                 125             


Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr 
    130                 135                 140                 


Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro 
145                 150                 155                 160 


Tyr Lys Asn Val Asn Ile Gln Asn Phe His Ile Ser Trp Lys Asp Gly 
                165                 170                 175     


Leu Gly Phe Cys Ala Leu Ile His Arg His Arg Pro Glu Leu Ile Asp 
            180                 185                 190         


Tyr Gly Lys Leu Arg Lys Asp Asp Pro Leu Thr Asn Leu Asn Thr Ala 
        195                 200                 205             


Phe Asp Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala 
    210                 215                 220                 


Glu Asp Ile Val Gly Thr Ala Arg Pro Asp Glu Lys Ala Ile Met Thr 
225                 230                 235                 240 


Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln Lys Ala Glu 
                245                 250                 255     


Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn 
            260                 265                 270         


Glu Gln Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp Leu Leu Glu 
        275                 280                 285             


Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asn Arg Val Pro Glu Asn 
    290                 295                 300                 


Thr Met His Ala Met Gln Gln Lys Leu Glu Asp Phe Arg Asp Tyr Arg 
305                 310                 315                 320 


Arg Leu His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln Leu Glu Ile 
                325                 330                 335     


Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn Arg Pro Ala 
            340                 345                 350         


Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn Asn Ala Trp 
        355                 360                 365             


Gly Cys Leu Glu Gln Val Glu Lys Gly Tyr Glu Glu Trp Leu Leu Asn 
    370                 375                 380                 


Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu Lys Phe Arg 
385                 390                 395                 400 


Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys Glu Ala Met 
                405                 410                 415     


Leu Arg Gln Lys Asp Tyr Glu Thr Ala Thr Leu Ser Glu Ile Lys Ala 
            420                 425                 430         


Leu Leu Lys Lys His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln 
        435                 440                 445             


Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu Asn Glu Leu 
    450                 455                 460                 


Asp Tyr Tyr Asp Ser Pro Ser Val Asn Ala Arg Cys Gln Lys Ile Cys 
465                 470                 475                 480 


Asp Gln Trp Asp Asn Leu Gly Ala Leu Thr Gln Lys Arg Arg Glu Ala 
                485                 490                 495     


Leu Glu Arg Thr Glu Lys Leu Leu Glu Thr Ile Asp Gln Leu Tyr Leu 
            500                 505                 510         


Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met Glu Gly Ala 
        515                 520                 525             


Met Glu Asp Leu Gln Asp Thr Phe Ile Val His Thr Ile Glu Glu Ile 
    530                 535                 540                 


Gln Gly Leu Thr Thr Ala His Glu Gln Phe Lys Ala Thr Leu Pro Asp 
545                 550                 555                 560 


Ala Asp Lys Glu Arg Leu Ala Ile Leu Gly Ile His Asn Glu Val Ser 
                565                 570                 575     


Lys Ile Val Gln Thr Tyr His Val Asn Met Ala Gly Thr Asn Pro Tyr 
            580                 585                 590         


Thr Thr Ile Thr Pro Gln Glu Ile Asn Gly Lys Trp Asp His Val Arg 
        595                 600                 605             


Gln Leu Val Pro Arg Arg Asp Gln Ala Leu Thr Glu Glu His Ala Arg 
    610                 615                 620                 


Gln Gln His Asn Glu Arg Leu Arg Lys Gln Phe Gly Ala Gln Ala Asn 
625                 630                 635                 640 


Val Ile Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile Gly Arg Ile 
                645                 650                 655     


Ser Ile Glu Met His Gly Thr Leu Glu Asp Gln Leu Ser His Leu Arg 
            660                 665                 670         


Gln Tyr Glu Lys Ser Ile Val Asn Tyr Lys Pro Lys Ile Asp Gln Leu 
        675                 680                 685             


Glu Gly Asp His Gln Leu Ile Gln Glu Ala Leu Ile Phe Asp Asn Lys 
    690                 695                 700                 


His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp Glu Gln Leu 
705                 710                 715                 720 


Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Ile Leu 
                725                 730                 735     


Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Asn Glu Phe Arg 
            740                 745                 750         


Ala Ser Phe Asn His Phe Asp Arg Asp His Ser Gly Thr Leu Gly Pro 
        755                 760                 765             


Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp Ile Gly Asn 
    770                 775                 780                 


Asp Pro Gln Gly Glu Ala Glu Phe Ala Arg Ile Met Ser Ile Val Asp 
785                 790                 795                 800 


Pro Asn Arg Leu Gly Val Val Thr Phe Gln Ala Phe Ile Asp Phe Met 
                805                 810                 815     


Ser Arg Glu Thr Ala Asp Thr Asp Thr Ala Asp Gln Val Met Ala Ser 
            820                 825                 830         


Phe Lys Ile Leu Ala Gly Asp Lys Asn Tyr Ile Thr Met Asp Glu Leu 
        835                 840                 845             


Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile Ala Arg Met 
    850                 855                 860                 


Ala Pro Tyr Thr Gly Pro Asp Ser Val Pro Gly Ala Leu Asp Tyr Met 
865                 870                 875                 880 


Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
                885                 890         


<210>  42
<211>  911
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Val Asp Tyr His Ala Ala Asn Gln Ser Tyr Gln Tyr Gly Pro Ser 
1               5                   10                  15      


Ser Ala Gly Asn Gly Ala Gly Gly Gly Gly Ser Met Gly Asp Tyr Met 
            20                  25                  30          


Ala Gln Glu Asp Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp 
        35                  40                  45              


Glu Lys Gln Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu 
    50                  55                  60                  


Arg Lys Ala Gly Thr Gln Ile Glu Asn Ile Asp Glu Asp Phe Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu 
                85                  90                  95      


Pro Lys Pro Glu Arg Gly Lys Met Arg Val His Lys Ile Asn Asn Val 
            100                 105                 110         


Asn Lys Ala Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser 
        115                 120                 125             


Ile Gly Ala Glu Glu Ile Val Asp Gly Asn Ala Lys Met Thr Leu Gly 
    130                 135                 140                 


Met Ile Trp Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val 
145                 150                 155                 160 


Glu Glu Thr Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys 
                165                 170                 175     


Thr Ala Pro Tyr Lys Asn Val Asn Val Gln Asn Phe His Ile Ser Trp 
            180                 185                 190         


Lys Asp Gly Leu Ala Phe Asn Ala Leu Ile His Arg His Arg Pro Glu 
        195                 200                 205             


Leu Ile Glu Tyr Asp Lys Leu Arg Lys Asp Asp Pro Val Thr Asn Leu 
    210                 215                 220                 


Asn Asn Ala Phe Glu Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met 
225                 230                 235                 240 


Leu Asp Ala Glu Asp Ile Val Asn Thr Ala Arg Pro Asp Glu Lys Ala 
                245                 250                 255     


Ile Met Thr Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln 
            260                 265                 270         


Lys Ala Glu Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn 
        275                 280                 285             


Gln Glu Asn Glu His Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp 
    290                 295                 300                 


Leu Leu Glu Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asp Arg Val 
305                 310                 315                 320 


Pro Gln Lys Thr Ile Gln Glu Met Gln Gln Lys Leu Glu Asp Phe Arg 
                325                 330                 335     


Asp Tyr Arg Arg Val His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln 
            340                 345                 350         


Leu Glu Ile Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn 
        355                 360                 365             


Arg Pro Ala Phe Met Pro Ser Glu Gly Lys Met Val Ser Asp Ile Asn 
    370                 375                 380                 


Asn Gly Trp Gln His Leu Glu Gln Ala Glu Lys Gly Tyr Glu Glu Trp 
385                 390                 395                 400 


Leu Leu Asn Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu 
                405                 410                 415     


Lys Phe Arg Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys 
            420                 425                 430         


Glu Ala Met Leu Lys His Arg Asp Tyr Glu Thr Ala Thr Leu Ser Asp 
        435                 440                 445             


Ile Lys Ala Leu Ile Arg Lys His Glu Ala Phe Glu Ser Asp Leu Ala 
    450                 455                 460                 


Ala His Gln Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu 
465                 470                 475                 480 


Asn Glu Leu Asp Tyr Tyr Asp Ser His Asn Val Asn Thr Arg Cys Gln 
                485                 490                 495     


Lys Ile Cys Asp Gln Trp Asp Ala Leu Gly Ser Leu Thr His Ser Arg 
            500                 505                 510         


Arg Glu Ala Leu Glu Lys Thr Glu Lys Gln Leu Glu Ala Ile Asp Gln 
        515                 520                 525             


Leu His Leu Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met 
    530                 535                 540                 


Glu Ser Ala Met Glu Asp Leu Gln Asp Met Phe Ile Val His Thr Ile 
545                 550                 555                 560 


Glu Glu Ile Glu Gly Leu Ile Ser Ala His Asp Gln Phe Lys Ser Thr 
                565                 570                 575     


Leu Pro Asp Ala Asp Arg Glu Arg Glu Ala Ile Leu Ala Ile His Lys 
            580                 585                 590         


Glu Ala Gln Arg Ile Ala Glu Ser Asn His Ile Lys Leu Ser Gly Ser 
        595                 600                 605             


Asn Pro Tyr Thr Thr Val Thr Pro Gln Ile Ile Asn Ser Lys Trp Glu 
    610                 615                 620                 


Lys Val Gln Gln Leu Val Pro Lys Arg Asp His Ala Leu Leu Glu Glu 
625                 630                 635                 640 


Gln Ser Lys Gln Gln Ser Asn Glu His Leu Arg Arg Gln Phe Ala Ser 
                645                 650                 655     


Gln Ala Asn Val Val Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile 
            660                 665                 670         


Gly Arg Ile Ser Ile Glu Met Asn Gly Thr Leu Glu Asp Gln Leu Ser 
        675                 680                 685             


His Leu Lys Gln Tyr Glu Arg Ser Ile Val Asp Tyr Lys Pro Asn Leu 
    690                 695                 700                 


Asp Leu Leu Glu Gln Gln His Gln Leu Ile Gln Glu Ala Leu Ile Phe 
705                 710                 715                 720 


Asp Asn Lys His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp 
                725                 730                 735     


Glu Gln Leu Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn 
            740                 745                 750         


Gln Ile Leu Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Gln 
        755                 760                 765             


Glu Phe Arg Ala Ser Phe Asn His Phe Asp Lys Asp His Gly Gly Ala 
    770                 775                 780                 


Leu Gly Pro Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp 
785                 790                 795                 800 


Val Glu Asn Asp Arg Gln Gly Glu Ala Glu Phe Asn Arg Ile Met Ser 
                805                 810                 815     


Leu Val Asp Pro Asn His Ser Gly Leu Val Thr Phe Gln Ala Phe Ile 
            820                 825                 830         


Asp Phe Met Ser Arg Glu Thr Thr Asp Thr Asp Thr Ala Asp Gln Val 
        835                 840                 845             


Ile Ala Ser Phe Lys Val Leu Ala Gly Asp Lys Asn Phe Ile Thr Ala 
    850                 855                 860                 


Glu Glu Leu Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile 
865                 870                 875                 880 


Ala Arg Met Ala Pro Tyr Gln Gly Pro Asp Ala Val Pro Gly Ala Leu 
                885                 890                 895     


Asp Tyr Lys Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
            900                 905                 910     


<210>  43
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  44
<211>  1744
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  45
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Ala 
1               5                   10                  15      


Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys 
            20                  25                  30          


Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp 
        35                  40                  45              


Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn 
    50                  55                  60                  


Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys 
65                  70                  75                  80  


Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser 
                85                  90                  95      


Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln 
            100                 105                 110         


Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr 
        115                 120                 125             


Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro 
    130                 135                 140                 


Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp 
145                 150                 155                 160 


Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe 
                165                 170                 175     


Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser 
            180                 185                 190         


Leu Arg Tyr Ser Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly 
        195                 200                 205             


Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro 
    210                 215                 220                 


Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val 
225                 230                 235                 240 


Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn 
                245                 250                 255     


Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp 
            260                 265                 270         


Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr 
        275                 280                 285             


Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu 
    290                 295                 300                 


Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met 
305                 310                 315                 320 


Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly 
                325                 330                 335     


Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr 
            340                 345                 350         


Asp Met Glu Gly Asn Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala 
        355                 360                 365             


Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala 
    370                 375                 380                 


Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val 
385                 390                 395                 400 


Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp 
                405                 410                 415     


Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala 
            420                 425                 430         


Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys 
        435                 440                 445             


Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala 
    450                 455                 460                 


Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser 
465                 470                 475                 480 


Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr 
                485                 490                 495     


Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala 
            500                 505                 510         


Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met 
        515                 520                 525             


Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu 
    530                 535                 540                 


Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp 
545                 550                 555                 560 


Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu 
                565                 570                 575     


Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln 
            580                 585                 590         


Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln 
        595                 600                 605             


Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr 
    610                 615                 620                 


Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp 
625                 630                 635                 640 


Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg 
                645                 650                 655     


Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu 
            660                 665                 670         


Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro 
        675                 680                 685             


Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp 
    690                 695                 700                 


Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu 
705                 710                 715                 720 


Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu 
                725                 730                 735     


Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu 
            740                 745                 750         


Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp 
        755                 760                 765             


Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp 
    770                 775                 780                 


Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala 
785                 790                 795                 800 


Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala 
                805                 810                 815     


Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile 
            820                 825                 830         


Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr 
        835                 840                 845             


Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly 
    850                 855                 860                 


Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly 
865                 870                 875                 880 


Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys 
                885                 890                 895     


Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp 
            900                 905     


<210>  46
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  46

Leu Gly Leu Ala Val Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe 
1               5                   10                  15      


Leu Asp Gly Asp Gly Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys 
            20                  25                  30          


Ser Asp Phe Gly Lys Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp 
        35                  40                  45              


Glu Glu Lys Asp Lys Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr 
    50                  55                  60                  


Ala Leu Ser Ala Ser Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu 
65                  70                  75                  80  


Val Val Gln Phe Thr Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly 
                85                  90                  95      


Gly Tyr Val Lys Leu Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His 
            100                 105                 110         


Gly Asp Ser Glu Tyr Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro 
        115                 120                 125             


Gly Thr Lys Lys Val His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val 
    130                 135                 140                 


Leu Ile Asn Lys Asp Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu 
145                 150                 155                 160 


Tyr Thr Leu Ile Val Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp 
                165                 170                 175     


Asn Ser Gln Val Glu Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu 
            180                 185                 190         


Pro Pro Lys Lys Ile Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp 
        195                 200                 205             


Asp Glu Arg Ala Lys Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp 
    210                 215                 220                 


Trp Asp Lys Pro Glu His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu 
225                 230                 235                 240 


Asp Trp Asp Glu Glu Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln 
                245                 250                 255     


Asn Pro Glu Tyr Lys Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro 
            260                 265                 270         


Asp Tyr Lys Gly Thr Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr 
        275                 280                 285             


Ser Pro Asp Pro Ser Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly 
    290                 295                 300                 


Leu Asp Leu Trp Gln Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu 
305                 310                 315                 320 


Ile Thr Asn Asp Glu Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp 
                325                 330                 335     


Gly Val Thr Lys Ala Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu 
            340                 345                 350         


Glu Gln Arg Leu Lys Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu 
        355                 360                 365             


Glu Glu Ala Glu Asp Lys Gly Asp Asp Glu Asp Lys Asp Glu Asp Glu 
    370                 375                 380                 


Glu Asp Glu Glu Asp Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly 
385                 390                 395                 400 


Gln Ala Lys Asp Glu Leu 
                405     


<210>  47
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Lys Glu Glu Gly Ser 
            100                 105                 110         


Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr Gly Trp Val His Asp 
        115                 120                 125             


Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly Lys Lys Val Gly Thr 
    130                 135                 140                 


Ala Ser Glu Asn Val Tyr Val Asn Thr Ala His Leu Lys Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp His Asn Phe Val Lys 
                165                 170                 175     


Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala Thr Thr Tyr Met Glu 
            180                 185                 190         


Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg Arg Ser Gly Gly His 
        195                 200                 205             


Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro Leu Thr Ala Glu Ile 
    210                 215                 220                 


Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp Asp Trp Arg Asn Val 
225                 230                 235                 240 


His Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Ala Ser Cys Gly 
                245                 250                 255     


Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu Glu Ala Arg Ile Arg 
            260                 265                 270         


Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val 
        275                 280                 285             


Val Ser Tyr Ser Gln Tyr Ala Gln Gly Cys Glu Gly Gly Phe Pro Tyr 
    290                 295                 300                 


Leu Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Leu Val Glu Glu Ala 
305                 310                 315                 320 


Cys Phe Pro Tyr Thr Gly Thr Asp Ser Pro Cys Lys Met Lys Glu Asp 
                325                 330                 335     


Cys Phe Arg Tyr Tyr Ser Ser Glu Tyr His Tyr Val Gly Gly Phe Tyr 
            340                 345                 350         


Gly Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val His His Gly 
        355                 360                 365             


Pro Met Ala Val Ala Phe Glu Val Tyr Asp Asp Phe Leu His Tyr Lys 
    370                 375                 380                 


Lys Gly Ile Tyr His His Thr Gly Leu Arg Asp Pro Phe Asn Pro Phe 
385                 390                 395                 400 


Glu Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Thr Asp Ser 
                405                 410                 415     


Ala Ser Gly Met Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Thr Gly 
            420                 425                 430         


Trp Gly Glu Asn Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys 
        435                 440                 445             


Ala Ile Glu Ser Ile Ala Val Ala Ala Thr Pro Ile Pro Lys Leu 
    450                 455                 460             


<210>  48
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Arg Arg Gly Pro Gly Trp Arg Pro Leu Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Ala Gly Ala Ala Gln Gly Gly Leu Tyr Phe Arg Arg Gly Gln Thr 
            20                  25                  30          


Cys Tyr Arg Pro Leu Arg Gly Asp Gly Leu Ala Pro Leu Gly Arg Ser 
        35                  40                  45              


Thr Tyr Pro Arg Pro His Glu Tyr Leu Ser Pro Ala Asp Leu Pro Lys 
    50                  55                  60                  


Ser Trp Asp Trp Arg Asn Val Asp Gly Val Asn Tyr Ala Ser Ile Thr 
65                  70                  75                  80  


Arg Asn Gln His Ile Pro Gln Tyr Cys Gly Ser Cys Trp Ala His Ala 
                85                  90                  95      


Ser Thr Ser Ala Met Ala Asp Arg Ile Asn Ile Lys Arg Lys Gly Ala 
            100                 105                 110         


Trp Pro Ser Thr Leu Leu Ser Val Gln Asn Val Ile Asp Cys Gly Asn 
        115                 120                 125             


Ala Gly Ser Cys Glu Gly Gly Asn Asp Leu Ser Val Trp Asp Tyr Ala 
    130                 135                 140                 


His Gln His Gly Ile Pro Asp Glu Thr Cys Asn Asn Tyr Gln Ala Lys 
145                 150                 155                 160 


Asp Gln Glu Cys Asp Lys Phe Asn Gln Cys Gly Thr Cys Asn Glu Phe 
                165                 170                 175     


Lys Glu Cys His Ala Ile Arg Asn Tyr Thr Leu Trp Arg Val Gly Asp 
            180                 185                 190         


Tyr Gly Ser Leu Ser Gly Arg Glu Lys Met Met Ala Glu Ile Tyr Ala 
        195                 200                 205             


Asn Gly Pro Ile Ser Cys Gly Ile Met Ala Thr Glu Arg Leu Ala Asn 
    210                 215                 220                 


Tyr Thr Gly Gly Ile Tyr Ala Glu Tyr Gln Asp Thr Thr Tyr Ile Asn 
225                 230                 235                 240 


His Val Val Ser Val Ala Gly Trp Gly Ile Ser Asp Gly Thr Glu Tyr 
                245                 250                 255     


Trp Ile Val Arg Asn Ser Trp Gly Glu Pro Trp Gly Glu Arg Gly Trp 
            260                 265                 270         


Leu Arg Ile Val Thr Ser Thr Tyr Lys Asp Gly Lys Gly Ala Arg Tyr 
        275                 280                 285             


Asn Ile Ala Ile Glu Glu His Cys Thr Phe Gly Asp Pro Ile Val 
    290                 295                 300             


<210>  49
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys 
1               5                   10                  15      


Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu 
            20                  25                  30          


Met Ser Glu Asp Glu Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu 
        35                  40                  45              


Asp Asp Ser Glu Glu Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys 
    50                  55                  60                  


Lys Ala Ala Lys Val Val Pro Val Lys Ala Lys Gly Ala Lys Asn Gly 
65                  70                  75                  80  


Lys Asn Ala Lys Lys Glu Asp Ser Asp Glu Glu Glu Asp Asp Asp Ser 
                85                  90                  95      


Glu Glu Asp Glu Glu Asp Asp Glu Asp Glu Asp Glu Asp Glu Asp Glu 
            100                 105                 110         


Ile Glu Pro Ala Ala Met Lys Ala Ala Ala Ala Ala Pro Ala Ser Glu 
        115                 120                 125             


Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Glu Asp Asp Asp Asp Asp 
    130                 135                 140                 


Glu Asp Asp Glu Asp Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Glu Glu Pro Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu 
                165                 170                 175     


Met Ala Lys Gln Lys Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu 
            180                 185                 190         


Gly Thr Glu Pro Thr Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn 
        195                 200                 205             


Phe Asn Lys Ser Ala Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe 
    210                 215                 220                 


Ala Lys Asn Asp Leu Ala Val Val Asp Val Arg Ile Gly Met Thr Arg 
225                 230                 235                 240 


Lys Phe Gly Tyr Val Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala 
                245                 250                 255     


Leu Glu Leu Thr Gly Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu 
            260                 265                 270         


Lys Pro Lys Gly Lys Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu 
        275                 280                 285             


Leu Ala Lys Asn Leu Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu 
    290                 295                 300                 


Val Phe Glu Asp Ala Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Asn 
305                 310                 315                 320 


Ser Lys Gly Ile Ala Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu 
                325                 330                 335     


Lys Thr Phe Glu Glu Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile 
            340                 345                 350         


Ser Leu Tyr Tyr Thr Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly 
        355                 360                 365             


Gly Lys Asn Ser Thr Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser 
    370                 375                 380                 


Asn Leu Ser Tyr Ser Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu 
385                 390                 395                 400 


Lys Ala Thr Phe Ile Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys 
                405                 410                 415     


Gly Tyr Ala Phe Ile Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala 
            420                 425                 430         


Leu Asn Ser Cys Asn Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu 
        435                 440                 445             


Glu Leu Gln Gly Pro Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser 
    450                 455                 460                 


Lys Thr Leu Phe Val Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr 
465                 470                 475                 480 


Leu Lys Glu Ser Phe Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp 
                485                 490                 495     


Arg Glu Thr Gly Ser Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser 
            500                 505                 510         


Glu Glu Asp Ala Lys Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile 
        515                 520                 525             


Asp Gly Asn Lys Val Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly 
    530                 535                 540                 


Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly 
545                 550                 555                 560 


Gly Gly Arg Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly 
                565                 570                 575     


Phe Gly Gly Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp 
            580                 585                 590         


His Lys Pro Gln Gly Lys Lys Thr Lys Phe Glu 
        595                 600             


<210>  50
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val Leu 
1               5                   10                  15      


Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met Leu 
            20                  25                  30          


Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala Val 
        35                  40                  45              


Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser Val 
    50                  55                  60                  


Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys Val 
65                  70                  75                  80  


Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile Leu 
                85                  90                  95      


Gly 
    


<210>  51
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210>  52
<211>  1838
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  53
<211>  1028
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp 
1               5                   10                  15      


Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln 
            20                  25                  30          


Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val 
        35                  40                  45              


Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser 
    50                  55                  60                  


Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys 
65                  70                  75                  80  


Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu 
                85                  90                  95      


Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala 
            100                 105                 110         


Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr 
        115                 120                 125             


Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly 
    130                 135                 140                 


Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val 
                165                 170                 175     


Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr 
            180                 185                 190         


Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr 
        195                 200                 205             


Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala 
    210                 215                 220                 


Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys 
225                 230                 235                 240 


Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg 
                245                 250                 255     


Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly 
            260                 265                 270         


Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg 
        275                 280                 285             


Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu 
                325                 330                 335     


Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp 
            340                 345                 350         


Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly 
        355                 360                 365             


Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg 
    370                 375                 380                 


Pro Gly Ser Ser Gly Pro Ser Gly Asp Glu Gly Gln Pro Gly Glu Pro 
385                 390                 395                 400 


Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly 
                405                 410                 415     


Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro 
            420                 425                 430         


Arg Gly Thr Pro Gly Thr Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala 
        435                 440                 445             


Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly 
    450                 455                 460                 


Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp 
465                 470                 475                 480 


Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala 
                485                 490                 495     


Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly 
            500                 505                 510         


Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro 
        515                 520                 525             


Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly 
    530                 535                 540                 


Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn 
545                 550                 555                 560 


Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro 
                565                 570                 575     


Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp 
            580                 585                 590         


Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu 
        595                 600                 605             


Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys 
625                 630                 635                 640 


Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly 
                645                 650                 655     


Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu 
            660                 665                 670         


His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys 
        675                 680                 685             


Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly 
    690                 695                 700                 


Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn 
705                 710                 715                 720 


Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg 
                725                 730                 735     


Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val 
            740                 745                 750         


Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln 
        755                 760                 765             


Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro 
    770                 775                 780                 


Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala 
785                 790                 795                 800 


Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro 
                805                 810                 815     


Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile 
            820                 825                 830         


Leu Leu Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr 
        835                 840                 845             


Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg 
    850                 855                 860                 


Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly 
865                 870                 875                 880 


Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn 
                885                 890                 895     


Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp 
            900                 905                 910         


Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg 
        915                 920                 925             


Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp 
    930                 935                 940                 


Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln 
945                 950                 955                 960 


Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg 
                965                 970                 975     


Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala 
            980                 985                 990         


Glu Tyr Asp Val Ala Tyr Gly Glu  Ser His Leu Phe Arg  Val Pro Ser 
        995                 1000                 1005             


Tyr Gln  Ala Leu Leu Arg Gly  Val Phe His Gln Thr  Val Ser Arg 
    1010                 1015                 1020             


Lys Val  Ala Leu Gly 
    1025             


<210>  54
<211>  3062
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Lys  Lys Leu Lys 
    1310                 1315                 1320             


Asp Glu  Gly Val Glu Leu Phe  Ala Ile Gly Ile Lys  Asn Ala Asp 
    1325                 1330                 1335             


Glu Val  Glu Leu Lys Met Ile  Ala Thr Asp Pro Asp  Asp Thr His 
    1340                 1345                 1350             


Ala Tyr  Asn Val Ala Asp Phe  Glu Ser Leu Ser Arg  Ile Val Asp 
    1355                 1360                 1365             


Asp Leu  Thr Ile Asn Leu Cys  Asn Ser Val Lys Gly  Pro Gly Asp 
    1370                 1375                 1380             


Leu Glu  Ala Pro Ser Asn Leu  Val Ile Ser Glu Arg  Thr His Arg 
    1385                 1390                 1395             


Ser Phe  Arg Val Ser Trp Thr  Pro Pro Ser Asp Ser  Val Asp Arg 
    1400                 1405                 1410             


Tyr Lys  Val Glu Tyr Tyr Pro  Val Ser Gly Gly Lys  Arg Gln Glu 
    1415                 1420                 1425             


Phe Tyr  Val Ser Arg Met Glu  Thr Ser Thr Val Leu  Lys Asp Leu 
    1430                 1435                 1440             


Lys Pro  Glu Thr Glu Tyr Val  Val Asn Val Tyr Ser  Val Val Glu 
    1445                 1450                 1455             


Asp Glu  Tyr Ser Glu Pro Leu  Lys Gly Thr Glu Lys  Thr Leu Pro 
    1460                 1465                 1470             


Val Pro  Val Val Ser Leu Asn  Ile Tyr Asp Val Gly  Pro Thr Thr 
    1475                 1480                 1485             


Met His  Val Gln Trp Gln Pro  Val Gly Gly Ala Thr  Gly Tyr Ile 
    1490                 1495                 1500             


Leu Ser  Tyr Lys Pro Val Lys  Asp Thr Glu Pro Thr  Arg Pro Lys 
    1505                 1510                 1515             


Glu Val  Arg Leu Gly Pro Thr  Val Asn Asp Met Gln  Leu Thr Asp 
    1520                 1525                 1530             


Leu Val  Pro Asn Thr Glu Tyr  Ala Val Thr Val Gln  Ala Val Leu 
    1535                 1540                 1545             


His Asp  Leu Thr Ser Glu Pro  Val Thr Val Arg Glu  Val Thr Leu 
    1550                 1555                 1560             


Pro Leu  Pro Arg Pro Gln Asp  Leu Lys Leu Arg Asp  Val Thr His 
    1565                 1570                 1575             


Ser Thr  Met Asn Val Phe Trp  Glu Pro Val Pro Gly  Lys Val Arg 
    1580                 1585                 1590             


Lys Tyr  Ile Val Arg Tyr Lys  Thr Pro Glu Glu Asp  Val Lys Glu 
    1595                 1600                 1605             


Val Glu  Val Asp Arg Ser Glu  Thr Ser Thr Ser Leu  Lys Asp Leu 
    1610                 1615                 1620             


Phe Ser  Gln Thr Leu Tyr Thr  Val Ser Val Ser Ala  Val His Asp 
    1625                 1630                 1635             


Glu Gly  Glu Ser Pro Pro Val  Thr Ala Gln Glu Thr  Thr Arg Pro 
    1640                 1645                 1650             


Val Pro  Ala Pro Thr Asn Leu  Lys Ile Thr Glu Val  Thr Ser Glu 
    1655                 1660                 1665             


Gly Phe  Arg Gly Thr Trp Asp  His Gly Ala Ser Asp  Val Ser Leu 
    1670                 1675                 1680             


Tyr Arg  Ile Thr Trp Ala Pro  Phe Gly Ser Ser Asp  Lys Met Glu 
    1685                 1690                 1695             


Thr Ile  Leu Asn Gly Asp Glu  Asn Thr Leu Val Phe  Glu Asn Leu 
    1700                 1705                 1710             


Asn Pro  Asn Thr Ile Tyr Glu  Val Ser Ile Thr Ala  Ile Tyr Pro 
    1715                 1720                 1725             


Asp Glu  Ser Glu Ser Asp Asp  Leu Ile Gly Ser Glu  Arg Thr Leu 
    1730                 1735                 1740             


Pro Ile  Leu Thr Thr Gln Ala  Pro Lys Ser Gly Pro  Arg Asn Leu 
    1745                 1750                 1755             


Gln Val  Tyr Asn Ala Thr Ser  Asn Ser Leu Thr Val  Lys Trp Asp 
    1760                 1765                 1770             


Pro Ala  Ser Gly Arg Val Gln  Lys Tyr Arg Ile Thr  Tyr Gln Pro 
    1775                 1780                 1785             


Ser Thr  Gly Glu Gly Asn Glu  Gln Thr Thr Thr Ile  Gly Gly Arg 
    1790                 1795                 1800             


Gln Asn  Ser Val Val Leu Gln  Lys Leu Lys Pro Asp  Thr Pro Tyr 
    1805                 1810                 1815             


Thr Ile  Thr Val Ser Ser Leu  Tyr Pro Asp Gly Glu  Gly Gly Arg 
    1820                 1825                 1830             


Met Thr  Gly Arg Gly Lys Thr  Lys Pro Leu Asn Thr  Val Arg Asn 
    1835                 1840                 1845             


Leu Arg  Val Tyr Asp Pro Ser  Thr Ser Thr Leu Asn  Val Arg Trp 
    1850                 1855                 1860             


Asp His  Ala Glu Gly Asn Pro  Arg Gln Tyr Lys Leu  Phe Tyr Ala 
    1865                 1870                 1875             


Pro Ala  Ala Gly Gly Pro Glu  Glu Leu Val Pro Ile  Pro Gly Asn 
    1880                 1885                 1890             


Thr Asn  Tyr Ala Ile Leu Arg  Asn Leu Gln Pro Asp  Thr Ser Tyr 
    1895                 1900                 1905             


Thr Val  Thr Val Val Pro Val  Tyr Thr Glu Gly Asp  Gly Gly Arg 
    1910                 1915                 1920             


Thr Ser  Asp Thr Gly Arg Thr  Leu Met Arg Gly Leu  Ala Arg Asn 
    1925                 1930                 1935             


Val Gln  Val Tyr Asn Pro Thr  Pro Asn Ser Leu Asp  Val Arg Trp 
    1940                 1945                 1950             


Asp Pro  Ala Pro Gly Pro Val  Leu Gln Tyr Arg Val  Val Tyr Ser 
    1955                 1960                 1965             


Pro Val  Asp Gly Thr Arg Pro  Ser Glu Ser Ile Val  Val Pro Gly 
    1970                 1975                 1980             


Asn Thr  Arg Met Val His Leu  Glu Arg Leu Ile Pro  Asp Thr Leu 
    1985                 1990                 1995             


Tyr Ser  Val Asn Leu Val Ala  Leu Tyr Ser Asp Gly  Glu Gly Asn 
    2000                 2005                 2010             


Pro Ser  Pro Ala Gln Gly Arg  Thr Leu Pro Arg Ser  Gly Pro Arg 
    2015                 2020                 2025             


Asn Leu  Arg Val Phe Gly Glu  Thr Thr Asn Ser Leu  Ser Val Ala 
    2030                 2035                 2040             


Trp Asp  His Ala Asp Gly Pro  Val Gln Gln Tyr Arg  Ile Ile Tyr 
    2045                 2050                 2055             


Ser Pro  Thr Val Gly Asp Pro  Ile Asp Glu Tyr Thr  Thr Val Pro 
    2060                 2065                 2070             


Gly Arg  Arg Asn Asn Val Ile  Leu Gln Pro Leu Gln  Pro Asp Thr 
    2075                 2080                 2085             


Pro Tyr  Lys Ile Thr Val Ile  Ala Val Tyr Glu Asp  Gly Asp Gly 
    2090                 2095                 2100             


Gly His  Leu Thr Gly Asn Gly  Arg Thr Val Gly Leu  Leu Pro Pro 
    2105                 2110                 2115             


Gln Asn  Ile His Ile Ser Asp  Glu Trp Tyr Thr Arg  Phe Arg Val 
    2120                 2125                 2130             


Ser Trp  Asp Pro Ser Pro Ser  Pro Val Leu Gly Tyr  Lys Ile Val 
    2135                 2140                 2145             


Tyr Lys  Pro Val Gly Ser Asn  Glu Pro Met Glu Ala  Phe Val Gly 
    2150                 2155                 2160             


Glu Met  Thr Ser Tyr Thr Leu  His Asn Leu Asn Pro  Ser Thr Thr 
    2165                 2170                 2175             


Tyr Asp  Val Asn Val Tyr Ala  Gln Tyr Asp Ser Gly  Leu Ser Val 
    2180                 2185                 2190             


Pro Leu  Thr Asp Gln Gly Thr  Thr Leu Tyr Leu Asn  Val Thr Asp 
    2195                 2200                 2205             


Leu Lys  Thr Tyr Gln Ile Gly  Trp Asp Thr Phe Cys  Val Lys Trp 
    2210                 2215                 2220             


Ser Pro  His Arg Ala Ala Thr  Ser Tyr Arg Leu Lys  Leu Ser Pro 
    2225                 2230                 2235             


Ala Asp  Gly Thr Arg Gly Gln  Glu Ile Thr Val Arg  Gly Ser Glu 
    2240                 2245                 2250             


Thr Ser  His Cys Phe Thr Gly  Leu Ser Pro Asp Thr  Asp Tyr Gly 
    2255                 2260                 2265             


Val Thr  Val Phe Val Gln Thr  Pro Asn Leu Glu Gly  Pro Gly Val 
    2270                 2275                 2280             


Ser Val  Lys Glu His Thr Thr  Val Lys Pro Thr Glu  Ala Pro Thr 
    2285                 2290                 2295             


Glu Pro  Pro Thr Pro Pro Pro  Pro Pro Thr Ile Pro  Pro Ala Arg 
    2300                 2305                 2310             


Asp Val  Cys Lys Gly Ala Lys  Ala Asp Ile Val Phe  Leu Thr Asp 
    2315                 2320                 2325             


Ala Ser  Trp Ser Ile Gly Asp  Asp Asn Phe Asn Lys  Val Val Lys 
    2330                 2335                 2340             


Phe Ile  Phe Asn Thr Val Gly  Gly Phe Asp Glu Ile  Ser Pro Ala 
    2345                 2350                 2355             


Gly Ile  Gln Val Ser Phe Val  Gln Tyr Ser Asp Glu  Val Lys Ser 
    2360                 2365                 2370             


Glu Phe  Lys Leu Asn Thr Tyr  Asn Asp Lys Ala Leu  Ala Leu Gly 
    2375                 2380                 2385             


Ala Leu  Gln Asn Ile Arg Tyr  Arg Gly Gly Asn Thr  Arg Thr Gly 
    2390                 2395                 2400             


Lys Ala  Leu Thr Phe Ile Lys  Glu Lys Val Leu Thr  Trp Glu Ser 
    2405                 2410                 2415             


Gly Met  Arg Lys Asn Val Pro  Lys Val Leu Val Val  Val Thr Asp 
    2420                 2425                 2430             


Gly Arg  Ser Gln Asp Glu Val  Lys Lys Ala Ala Leu  Val Ile Gln 
    2435                 2440                 2445             


Gln Ser  Gly Phe Ser Val Phe  Val Val Gly Val Ala  Asp Val Asp 
    2450                 2455                 2460             


Tyr Asn  Glu Leu Ala Asn Ile  Ala Ser Lys Pro Ser  Glu Arg His 
    2465                 2470                 2475             


Val Phe  Ile Val Asp Asp Phe  Glu Ser Phe Glu Lys  Ile Glu Asp 
    2480                 2485                 2490             


Asn Leu  Ile Thr Phe Val Cys  Glu Thr Ala Thr Ser  Ser Cys Pro 
    2495                 2500                 2505             


Leu Ile  Tyr Leu Asp Gly Tyr  Thr Ser Pro Gly Phe  Lys Met Leu 
    2510                 2515                 2520             


Glu Ala  Tyr Asn Leu Thr Glu  Lys Asn Phe Ala Ser  Val Gln Gly 
    2525                 2530                 2535             


Val Ser  Leu Glu Ser Gly Ser  Phe Pro Ser Tyr Ser  Ala Tyr Arg 
    2540                 2545                 2550             


Ile Gln  Lys Asn Ala Phe Val  Asn Gln Pro Thr Ala  Asp Leu His 
    2555                 2560                 2565             


Pro Asn  Gly Leu Pro Pro Ser  Tyr Thr Ile Ile Leu  Leu Phe Arg 
    2570                 2575                 2580             


Leu Leu  Pro Glu Thr Pro Ser  Asp Pro Phe Ala Ile  Trp Gln Ile 
    2585                 2590                 2595             


Thr Asp  Arg Asp Tyr Lys Pro  Gln Val Gly Val Ile  Ala Asp Pro 
    2600                 2605                 2610             


Ser Ser  Lys Thr Leu Ser Phe  Phe Asn Lys Asp Thr  Arg Gly Glu 
    2615                 2620                 2625             


Val Gln  Thr Val Thr Phe Asp  Thr Glu Glu Val Lys  Thr Leu Phe 
    2630                 2635                 2640             


Tyr Gly  Ser Phe His Lys Val  His Ile Val Val Thr  Ser Lys Ser 
    2645                 2650                 2655             


Val Lys  Ile Tyr Ile Asp Cys  Tyr Glu Ile Ile Glu  Lys Asp Ile 
    2660                 2665                 2670             


Lys Glu  Ala Gly Asn Ile Thr  Thr Asp Gly Tyr Glu  Ile Leu Gly 
    2675                 2680                 2685             


Lys Leu  Leu Lys Gly Glu Arg  Lys Ser Ala Ala Phe  Gln Ile Gln 
    2690                 2695                 2700             


Ser Phe  Asp Ile Val Cys Ser  Pro Val Trp Thr Ser  Arg Asp Arg 
    2705                 2710                 2715             


Cys Cys  Asp Ile Pro Ser Arg  Arg Asp Glu Gly Lys  Cys Pro Ala 
    2720                 2725                 2730             


Phe Pro  Asn Ser Cys Thr Cys  Thr Gln Asp Ser Val  Gly Pro Pro 
    2735                 2740                 2745             


Gly Pro  Pro Gly Pro Ala Gly  Gly Pro Gly Ala Lys  Gly Pro Arg 
    2750                 2755                 2760             


Gly Glu  Arg Gly Ile Ser Gly  Ala Ile Gly Pro Pro  Gly Pro Arg 
    2765                 2770                 2775             


Gly Asp  Ile Gly Pro Pro Gly  Pro Gln Gly Pro Pro  Gly Pro Gln 
    2780                 2785                 2790             


Gly Pro  Asn Gly Leu Ser Ile  Pro Gly Glu Gln Gly  Arg Gln Gly 
    2795                 2800                 2805             


Met Lys  Gly Asp Ala Gly Glu  Pro Gly Leu Pro Gly  Arg Thr Gly 
    2810                 2815                 2820             


Thr Pro  Gly Leu Pro Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly 
    2825                 2830                 2835             


Asp Arg  Gly Phe Thr Gly Lys  Asp Gly Ala Met Gly  Pro Arg Gly 
    2840                 2845                 2850             


Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Ser Pro Gly  Val Thr Gly 
    2855                 2860                 2865             


Pro Ser  Gly Lys Pro Gly Lys  Pro Gly Asp His Gly  Arg Pro Gly 
    2870                 2875                 2880             


Pro Ser  Gly Leu Lys Gly Glu  Lys Gly Asp Arg Gly  Asp Ile Ala 
    2885                 2890                 2895             


Ser Gln  Asn Met Met Arg Ala  Val Ala Arg Gln Val  Cys Glu Gln 
    2900                 2905                 2910             


Leu Ile  Ser Gly Gln Met Asn  Arg Phe Asn Gln Met  Leu Asn Gln 
    2915                 2920                 2925             


Ile Pro  Asn Asp Tyr Gln Ser  Ser Arg Asn Gln Pro  Gly Pro Pro 
    2930                 2935                 2940             


Gly Pro  Pro Gly Pro Pro Gly  Ser Ala Gly Ala Arg  Gly Glu Pro 
    2945                 2950                 2955             


Gly Pro  Gly Gly Arg Pro Gly  Phe Pro Gly Thr Pro  Gly Met Gln 
    2960                 2965                 2970             


Gly Pro  Pro Gly Glu Arg Gly  Leu Pro Gly Glu Lys  Gly Glu Arg 
    2975                 2980                 2985             


Gly Thr  Gly Ser Ser Gly Pro  Arg Gly Leu Pro Gly  Pro Pro Gly 
    2990                 2995                 3000             


Pro Gln  Gly Glu Ser Arg Thr  Gly Pro Pro Gly Ser  Thr Gly Ser 
    3005                 3010                 3015             


Arg Gly  Pro Pro Gly Pro Pro  Gly Arg Pro Gly Asn  Ser Gly Ile 
    3020                 3025                 3030             


Arg Gly  Pro Pro Gly Pro Pro  Gly Tyr Cys Asp Ser  Ser Gln Cys 
    3035                 3040                 3045             


Ala Ser  Ile Pro Tyr Asn Gly  Gln Gly Tyr Pro Gly  Ser Gly 
    3050                 3055                 3060         


<210>  55
<211>  3063
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu 
1               5                   10                  15      


Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn 
            20                  25                  30          


Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro 
        35                  40                  45              


Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp 
    50                  55                  60                  


Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu 
65                  70                  75                  80  


Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser 
                85                  90                  95      


Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile 
            100                 105                 110         


Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr 
        115                 120                 125             


Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu 
    130                 135                 140                 


Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu 
145                 150                 155                 160 


Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys 
                165                 170                 175     


Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe 
            180                 185                 190         


Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys 
        195                 200                 205             


Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp 
    210                 215                 220                 


Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly 
225                 230                 235                 240 


Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu 
                245                 250                 255     


Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe 
            260                 265                 270         


Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala 
        275                 280                 285             


Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala 
    290                 295                 300                 


Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val 
305                 310                 315                 320 


Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro 
                325                 330                 335     


Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu 
            340                 345                 350         


Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu 
        355                 360                 365             


Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro 
    370                 375                 380                 


Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr 
385                 390                 395                 400 


Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile 
                405                 410                 415     


Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser 
            420                 425                 430         


Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser 
        435                 440                 445             


Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu 
    450                 455                 460                 


Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser 
465                 470                 475                 480 


Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys 
                485                 490                 495     


Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr 
            500                 505                 510         


Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu 
        515                 520                 525             


Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val 
    530                 535                 540                 


Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro 
545                 550                 555                 560 


Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val 
                565                 570                 575     


Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala 
            580                 585                 590         


Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile 
        595                 600                 605             


Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu 
    610                 615                 620                 


Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe 
625                 630                 635                 640 


Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly 
                645                 650                 655     


Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp 
            660                 665                 670         


Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu 
        675                 680                 685             


Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu 
    690                 695                 700                 


Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu 
705                 710                 715                 720 


Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr 
                725                 730                 735     


Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg 
            740                 745                 750         


Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val 
        755                 760                 765             


Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro 
    770                 775                 780                 


Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro 
785                 790                 795                 800 


Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn 
                805                 810                 815     


Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu 
            820                 825                 830         


Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr 
        835                 840                 845             


Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp 
    850                 855                 860                 


Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala 
865                 870                 875                 880 


Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe 
                885                 890                 895     


Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val 
            900                 905                 910         


Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala 
        915                 920                 925             


Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp 
    930                 935                 940                 


Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr 
945                 950                 955                 960 


Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe 
                965                 970                 975     


Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr 
            980                 985                 990         


Thr Glu Leu Ser Gln Asp Ser Lys  Thr Leu Lys Val Asp  Glu Glu Thr 
        995                 1000                 1005             


Glu Asn  Thr Met Arg Val Thr  Trp Lys Pro Ala Pro  Gly Lys Val 
    1010                 1015                 1020             


Val Asn  Tyr Arg Val Val Tyr  Arg Pro His Gly Arg  Gly Lys Gln 
    1025                 1030                 1035             


Met Val  Ala Lys Val Pro Pro  Thr Val Thr Ser Thr  Val Leu Lys 
    1040                 1045                 1050             


Arg Leu  Gln Pro Gln Thr Thr  Tyr Asp Ile Thr Val  Leu Pro Ile 
    1055                 1060                 1065             


Tyr Lys  Met Gly Glu Gly Lys  Leu Arg Gln Gly Ser  Gly Thr Thr 
    1070                 1075                 1080             


Ala Ser  Arg Phe Lys Ser Pro  Arg Asn Leu Lys Thr  Ser Asp Pro 
    1085                 1090                 1095             


Thr Met  Ser Ser Phe Arg Val  Thr Trp Glu Pro Ala  Pro Gly Glu 
    1100                 1105                 1110             


Val Lys  Gly Tyr Lys Val Thr  Phe His Pro Thr Gly  Asp Asp Arg 
    1115                 1120                 1125             


Arg Leu  Gly Glu Leu Val Val  Gly Pro Tyr Asp Asn  Thr Val Val 
    1130                 1135                 1140             


Leu Glu  Glu Leu Arg Ala Gly  Thr Thr Tyr Lys Val  Asn Val Phe 
    1145                 1150                 1155             


Gly Met  Phe Asp Gly Gly Glu  Ser Ser Pro Leu Val  Gly Gln Glu 
    1160                 1165                 1170             


Met Thr  Thr Leu Ser Asp Thr  Thr Val Met Pro Ile  Leu Ser Ser 
    1175                 1180                 1185             


Gly Met  Glu Cys Leu Thr Arg  Ala Glu Ala Asp Ile  Val Leu Leu 
    1190                 1195                 1200             


Val Asp  Gly Ser Trp Ser Ile  Gly Arg Ala Asn Phe  Arg Thr Val 
    1205                 1210                 1215             


Arg Ser  Phe Ile Ser Arg Ile  Val Glu Val Phe Asp  Ile Gly Pro 
    1220                 1225                 1230             


Lys Arg  Val Gln Ile Ala Leu  Ala Gln Tyr Ser Gly  Asp Pro Arg 
    1235                 1240                 1245             


Thr Glu  Trp Gln Leu Asn Ala  His Arg Asp Lys Lys  Ser Leu Leu 
    1250                 1255                 1260             


Gln Ala  Val Ala Asn Leu Pro  Tyr Lys Gly Gly Asn  Thr Leu Thr 
    1265                 1270                 1275             


Gly Met  Ala Leu Asn Phe Ile  Arg Gln Gln Asn Phe  Arg Thr Gln 
    1280                 1285                 1290             


Ala Gly  Met Arg Pro Arg Ala  Arg Lys Ile Gly Val  Leu Ile Thr 
    1295                 1300                 1305             


Asp Gly  Lys Ser Gln Asp Asp  Val Glu Ala Pro Ser  Lys Lys Leu 
    1310                 1315                 1320             


Lys Asp  Glu Gly Val Glu Leu  Phe Ala Ile Gly Ile  Lys Asn Ala 
    1325                 1330                 1335             


Asp Glu  Val Glu Leu Lys Met  Ile Ala Thr Asp Pro  Asp Asp Thr 
    1340                 1345                 1350             


His Ala  Tyr Asn Val Ala Asp  Phe Glu Ser Leu Ser  Arg Ile Val 
    1355                 1360                 1365             


Asp Asp  Leu Thr Ile Asn Leu  Cys Asn Ser Val Lys  Gly Pro Gly 
    1370                 1375                 1380             


Asp Leu  Glu Ala Pro Ser Asn  Leu Val Ile Ser Glu  Arg Thr His 
    1385                 1390                 1395             


Arg Ser  Phe Arg Val Ser Trp  Thr Pro Pro Ser Asp  Ser Val Asp 
    1400                 1405                 1410             


Arg Tyr  Lys Val Glu Tyr Tyr  Pro Val Ser Gly Gly  Lys Arg Gln 
    1415                 1420                 1425             


Glu Phe  Tyr Val Ser Arg Met  Glu Thr Ser Thr Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Lys  Pro Glu Thr Glu Tyr  Val Val Asn Val Tyr  Ser Val Val 
    1445                 1450                 1455             


Glu Asp  Glu Tyr Ser Glu Pro  Leu Lys Gly Thr Glu  Lys Thr Leu 
    1460                 1465                 1470             


Pro Val  Pro Val Val Ser Leu  Asn Ile Tyr Asp Val  Gly Pro Thr 
    1475                 1480                 1485             


Thr Met  His Val Gln Trp Gln  Pro Val Gly Gly Ala  Thr Gly Tyr 
    1490                 1495                 1500             


Ile Leu  Ser Tyr Lys Pro Val  Lys Asp Thr Glu Pro  Thr Arg Pro 
    1505                 1510                 1515             


Lys Glu  Val Arg Leu Gly Pro  Thr Val Asn Asp Met  Gln Leu Thr 
    1520                 1525                 1530             


Asp Leu  Val Pro Asn Thr Glu  Tyr Ala Val Thr Val  Gln Ala Val 
    1535                 1540                 1545             


Leu His  Asp Leu Thr Ser Glu  Pro Val Thr Val Arg  Glu Val Thr 
    1550                 1555                 1560             


Leu Pro  Leu Pro Arg Pro Gln  Asp Leu Lys Leu Arg  Asp Val Thr 
    1565                 1570                 1575             


His Ser  Thr Met Asn Val Phe  Trp Glu Pro Val Pro  Gly Lys Val 
    1580                 1585                 1590             


Arg Lys  Tyr Ile Val Arg Tyr  Lys Thr Pro Glu Glu  Asp Val Lys 
    1595                 1600                 1605             


Glu Val  Glu Val Asp Arg Ser  Glu Thr Ser Thr Ser  Leu Lys Asp 
    1610                 1615                 1620             


Leu Phe  Ser Gln Thr Leu Tyr  Thr Val Ser Val Ser  Ala Val His 
    1625                 1630                 1635             


Asp Glu  Gly Glu Ser Pro Pro  Val Thr Ala Gln Glu  Thr Thr Arg 
    1640                 1645                 1650             


Pro Val  Pro Ala Pro Thr Asn  Leu Lys Ile Thr Glu  Val Thr Ser 
    1655                 1660                 1665             


Glu Gly  Phe Arg Gly Thr Trp  Asp His Gly Ala Ser  Asp Val Ser 
    1670                 1675                 1680             


Leu Tyr  Arg Ile Thr Trp Ala  Pro Phe Gly Ser Ser  Asp Lys Met 
    1685                 1690                 1695             


Glu Thr  Ile Leu Asn Gly Asp  Glu Asn Thr Leu Val  Phe Glu Asn 
    1700                 1705                 1710             


Leu Asn  Pro Asn Thr Ile Tyr  Glu Val Ser Ile Thr  Ala Ile Tyr 
    1715                 1720                 1725             


Pro Asp  Glu Ser Glu Ser Asp  Asp Leu Ile Gly Ser  Glu Arg Thr 
    1730                 1735                 1740             


Leu Pro  Ile Leu Thr Thr Gln  Ala Pro Lys Ser Gly  Pro Arg Asn 
    1745                 1750                 1755             


Leu Gln  Val Tyr Asn Ala Thr  Ser Asn Ser Leu Thr  Val Lys Trp 
    1760                 1765                 1770             


Asp Pro  Ala Ser Gly Arg Val  Gln Lys Tyr Arg Ile  Thr Tyr Gln 
    1775                 1780                 1785             


Pro Ser  Thr Gly Glu Gly Asn  Glu Gln Thr Thr Thr  Ile Gly Gly 
    1790                 1795                 1800             


Arg Gln  Asn Ser Val Val Leu  Gln Lys Leu Lys Pro  Asp Thr Pro 
    1805                 1810                 1815             


Tyr Thr  Ile Thr Val Ser Ser  Leu Tyr Pro Asp Gly  Glu Gly Gly 
    1820                 1825                 1830             


Arg Met  Thr Gly Arg Gly Lys  Thr Lys Pro Leu Asn  Thr Val Arg 
    1835                 1840                 1845             


Asn Leu  Arg Val Tyr Asp Pro  Ser Thr Ser Thr Leu  Asn Val Arg 
    1850                 1855                 1860             


Trp Asp  His Ala Glu Gly Asn  Pro Arg Gln Tyr Lys  Leu Phe Tyr 
    1865                 1870                 1875             


Ala Pro  Ala Ala Gly Gly Pro  Glu Glu Leu Val Pro  Ile Pro Gly 
    1880                 1885                 1890             


Asn Thr  Asn Tyr Ala Ile Leu  Arg Asn Leu Gln Pro  Asp Thr Ser 
    1895                 1900                 1905             


Tyr Thr  Val Thr Val Val Pro  Val Tyr Thr Glu Gly  Asp Gly Gly 
    1910                 1915                 1920             


Arg Thr  Ser Asp Thr Gly Arg  Thr Leu Met Arg Gly  Leu Ala Arg 
    1925                 1930                 1935             


Asn Val  Gln Val Tyr Asn Pro  Thr Pro Asn Ser Leu  Asp Val Arg 
    1940                 1945                 1950             


Trp Asp  Pro Ala Pro Gly Pro  Val Leu Gln Tyr Arg  Val Val Tyr 
    1955                 1960                 1965             


Ser Pro  Val Asp Gly Thr Arg  Pro Ser Glu Ser Ile  Val Val Pro 
    1970                 1975                 1980             


Gly Asn  Thr Arg Met Val His  Leu Glu Arg Leu Ile  Pro Asp Thr 
    1985                 1990                 1995             


Leu Tyr  Ser Val Asn Leu Val  Ala Leu Tyr Ser Asp  Gly Glu Gly 
    2000                 2005                 2010             


Asn Pro  Ser Pro Ala Gln Gly  Arg Thr Leu Pro Arg  Ser Gly Pro 
    2015                 2020                 2025             


Arg Asn  Leu Arg Val Phe Gly  Glu Thr Thr Asn Ser  Leu Ser Val 
    2030                 2035                 2040             


Ala Trp  Asp His Ala Asp Gly  Pro Val Gln Gln Tyr  Arg Ile Ile 
    2045                 2050                 2055             


Tyr Ser  Pro Thr Val Gly Asp  Pro Ile Asp Glu Tyr  Thr Thr Val 
    2060                 2065                 2070             


Pro Gly  Arg Arg Asn Asn Val  Ile Leu Gln Pro Leu  Gln Pro Asp 
    2075                 2080                 2085             


Thr Pro  Tyr Lys Ile Thr Val  Ile Ala Val Tyr Glu  Asp Gly Asp 
    2090                 2095                 2100             


Gly Gly  His Leu Thr Gly Asn  Gly Arg Thr Val Gly  Leu Leu Pro 
    2105                 2110                 2115             


Pro Gln  Asn Ile His Ile Ser  Asp Glu Trp Tyr Thr  Arg Phe Arg 
    2120                 2125                 2130             


Val Ser  Trp Asp Pro Ser Pro  Ser Pro Val Leu Gly  Tyr Lys Ile 
    2135                 2140                 2145             


Val Tyr  Lys Pro Val Gly Ser  Asn Glu Pro Met Glu  Ala Phe Val 
    2150                 2155                 2160             


Gly Glu  Met Thr Ser Tyr Thr  Leu His Asn Leu Asn  Pro Ser Thr 
    2165                 2170                 2175             


Thr Tyr  Asp Val Asn Val Tyr  Ala Gln Tyr Asp Ser  Gly Leu Ser 
    2180                 2185                 2190             


Val Pro  Leu Thr Asp Gln Gly  Thr Thr Leu Tyr Leu  Asn Val Thr 
    2195                 2200                 2205             


Asp Leu  Lys Thr Tyr Gln Ile  Gly Trp Asp Thr Phe  Cys Val Lys 
    2210                 2215                 2220             


Trp Ser  Pro His Arg Ala Ala  Thr Ser Tyr Arg Leu  Lys Leu Ser 
    2225                 2230                 2235             


Pro Ala  Asp Gly Thr Arg Gly  Gln Glu Ile Thr Val  Arg Gly Ser 
    2240                 2245                 2250             


Glu Thr  Ser His Cys Phe Thr  Gly Leu Ser Pro Asp  Thr Asp Tyr 
    2255                 2260                 2265             


Gly Val  Thr Val Phe Val Gln  Thr Pro Asn Leu Glu  Gly Pro Gly 
    2270                 2275                 2280             


Val Ser  Val Lys Glu His Thr  Thr Val Lys Pro Thr  Glu Ala Pro 
    2285                 2290                 2295             


Thr Glu  Pro Pro Thr Pro Pro  Pro Pro Pro Thr Ile  Pro Pro Ala 
    2300                 2305                 2310             


Arg Asp  Val Cys Lys Gly Ala  Lys Ala Asp Ile Val  Phe Leu Thr 
    2315                 2320                 2325             


Asp Ala  Ser Trp Ser Ile Gly  Asp Asp Asn Phe Asn  Lys Val Val 
    2330                 2335                 2340             


Lys Phe  Ile Phe Asn Thr Val  Gly Gly Phe Asp Glu  Ile Ser Pro 
    2345                 2350                 2355             


Ala Gly  Ile Gln Val Ser Phe  Val Gln Tyr Ser Asp  Glu Val Lys 
    2360                 2365                 2370             


Ser Glu  Phe Lys Leu Asn Thr  Tyr Asn Asp Lys Ala  Leu Ala Leu 
    2375                 2380                 2385             


Gly Ala  Leu Gln Asn Ile Arg  Tyr Arg Gly Gly Asn  Thr Arg Thr 
    2390                 2395                 2400             


Gly Lys  Ala Leu Thr Phe Ile  Lys Glu Lys Val Leu  Thr Trp Glu 
    2405                 2410                 2415             


Ser Gly  Met Arg Lys Asn Val  Pro Lys Val Leu Val  Val Val Thr 
    2420                 2425                 2430             


Asp Gly  Arg Ser Gln Asp Glu  Val Lys Lys Ala Ala  Leu Val Ile 
    2435                 2440                 2445             


Gln Gln  Ser Gly Phe Ser Val  Phe Val Val Gly Val  Ala Asp Val 
    2450                 2455                 2460             


Asp Tyr  Asn Glu Leu Ala Asn  Ile Ala Ser Lys Pro  Ser Glu Arg 
    2465                 2470                 2475             


His Val  Phe Ile Val Asp Asp  Phe Glu Ser Phe Glu  Lys Ile Glu 
    2480                 2485                 2490             


Asp Asn  Leu Ile Thr Phe Val  Cys Glu Thr Ala Thr  Ser Ser Cys 
    2495                 2500                 2505             


Pro Leu  Ile Tyr Leu Asp Gly  Tyr Thr Ser Pro Gly  Phe Lys Met 
    2510                 2515                 2520             


Leu Glu  Ala Tyr Asn Leu Thr  Glu Lys Asn Phe Ala  Ser Val Gln 
    2525                 2530                 2535             


Gly Val  Ser Leu Glu Ser Gly  Ser Phe Pro Ser Tyr  Ser Ala Tyr 
    2540                 2545                 2550             


Arg Ile  Gln Lys Asn Ala Phe  Val Asn Gln Pro Thr  Ala Asp Leu 
    2555                 2560                 2565             


His Pro  Asn Gly Leu Pro Pro  Ser Tyr Thr Ile Ile  Leu Leu Phe 
    2570                 2575                 2580             


Arg Leu  Leu Pro Glu Thr Pro  Ser Asp Pro Phe Ala  Ile Trp Gln 
    2585                 2590                 2595             


Ile Thr  Asp Arg Asp Tyr Lys  Pro Gln Val Gly Val  Ile Ala Asp 
    2600                 2605                 2610             


Pro Ser  Ser Lys Thr Leu Ser  Phe Phe Asn Lys Asp  Thr Arg Gly 
    2615                 2620                 2625             


Glu Val  Gln Thr Val Thr Phe  Asp Thr Glu Glu Val  Lys Thr Leu 
    2630                 2635                 2640             


Phe Tyr  Gly Ser Phe His Lys  Val His Ile Val Val  Thr Ser Lys 
    2645                 2650                 2655             


Ser Val  Lys Ile Tyr Ile Asp  Cys Tyr Glu Ile Ile  Glu Lys Asp 
    2660                 2665                 2670             


Ile Lys  Glu Ala Gly Asn Ile  Thr Thr Asp Gly Tyr  Glu Ile Leu 
    2675                 2680                 2685             


Gly Lys  Leu Leu Lys Gly Glu  Arg Lys Ser Ala Ala  Phe Gln Ile 
    2690                 2695                 2700             


Gln Ser  Phe Asp Ile Val Cys  Ser Pro Val Trp Thr  Ser Arg Asp 
    2705                 2710                 2715             


Arg Cys  Cys Asp Ile Pro Ser  Arg Arg Asp Glu Gly  Lys Cys Pro 
    2720                 2725                 2730             


Ala Phe  Pro Asn Ser Cys Thr  Cys Thr Gln Asp Ser  Val Gly Pro 
    2735                 2740                 2745             


Pro Gly  Pro Pro Gly Pro Ala  Gly Gly Pro Gly Ala  Lys Gly Pro 
    2750                 2755                 2760             


Arg Gly  Glu Arg Gly Ile Ser  Gly Ala Ile Gly Pro  Pro Gly Pro 
    2765                 2770                 2775             


Arg Gly  Asp Ile Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Pro 
    2780                 2785                 2790             


Gln Gly  Pro Asn Gly Leu Ser  Ile Pro Gly Glu Gln  Gly Arg Gln 
    2795                 2800                 2805             


Gly Met  Lys Gly Asp Ala Gly  Glu Pro Gly Leu Pro  Gly Arg Thr 
    2810                 2815                 2820             


Gly Thr  Pro Gly Leu Pro Gly  Pro Pro Gly Pro Met  Gly Pro Pro 
    2825                 2830                 2835             


Gly Asp  Arg Gly Phe Thr Gly  Lys Asp Gly Ala Met  Gly Pro Arg 
    2840                 2845                 2850             


Gly Pro  Pro Gly Pro Pro Gly  Ser Pro Gly Ser Pro  Gly Val Thr 
    2855                 2860                 2865             


Gly Pro  Ser Gly Lys Pro Gly  Lys Pro Gly Asp His  Gly Arg Pro 
    2870                 2875                 2880             


Gly Pro  Ser Gly Leu Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ile 
    2885                 2890                 2895             


Ala Ser  Gln Asn Met Met Arg  Ala Val Ala Arg Gln  Val Cys Glu 
    2900                 2905                 2910             


Gln Leu  Ile Ser Gly Gln Met  Asn Arg Phe Asn Gln  Met Leu Asn 
    2915                 2920                 2925             


Gln Ile  Pro Asn Asp Tyr Gln  Ser Ser Arg Asn Gln  Pro Gly Pro 
    2930                 2935                 2940             


Pro Gly  Pro Pro Gly Pro Pro  Gly Ser Ala Gly Ala  Arg Gly Glu 
    2945                 2950                 2955             


Pro Gly  Pro Gly Gly Arg Pro  Gly Phe Pro Gly Thr  Pro Gly Met 
    2960                 2965                 2970             


Gln Gly  Pro Pro Gly Glu Arg  Gly Leu Pro Gly Glu  Lys Gly Glu 
    2975                 2980                 2985             


Arg Gly  Thr Gly Ser Ser Gly  Pro Arg Gly Leu Pro  Gly Pro Pro 
    2990                 2995                 3000             


Gly Pro  Gln Gly Glu Ser Arg  Thr Gly Pro Pro Gly  Ser Thr Gly 
    3005                 3010                 3015             


Ser Arg  Gly Pro Pro Gly Pro  Pro Gly Arg Pro Gly  Asn Ser Gly 
    3020                 3025                 3030             


Ile Arg  Gly Pro Pro Gly Pro  Pro Gly Tyr Cys Asp  Ser Ser Gln 
    3035                 3040                 3045             


Cys Ala  Ser Ile Pro Tyr Asn  Gly Gln Gly Tyr Pro  Gly Ser Gly 
    3050                 3055                 3060             


<210>  56
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  57
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                165                 170                 175     


Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
            180                 185                 190         


Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
        195                 200                 205             


Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
    210                 215                 220                 


His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
225                 230                 235                 240 


Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                245                 250                 255     


Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
            260                 265                 270         


Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
        275                 280                 285             


Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
305                 310                 315                 320 


Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                325                 330                 335     


Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
            340                 345                 350         


Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
        355                 360                 365             


Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
    370                 375                 380                 


Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
385                 390                 395                 400 


Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                405                 410                 415     


Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
            420                 425                 430         


Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
        435                 440                 445             


Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
    450                 455                 460                 


Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
465                 470                 475                 480 


Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                485                 490             


<210>  58
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Leu Lys Ala Leu Phe Leu Thr Met Leu Thr Leu Ala Leu Val Lys 
1               5                   10                  15      


Ser Gln Asp Thr Glu Glu Thr Ile Thr Tyr Thr Gln Cys Thr Asp Gly 
            20                  25                  30          


Tyr Glu Trp Asp Pro Val Arg Gln Gln Cys Lys Asp Ile Asp Glu Cys 
        35                  40                  45              


Asp Ile Val Pro Asp Ala Cys Lys Gly Gly Met Lys Cys Val Asn His 
    50                  55                  60                  


Tyr Gly Gly Tyr Leu Cys Leu Pro Lys Thr Ala Gln Ile Ile Val Asn 
65                  70                  75                  80  


Asn Glu Gln Pro Gln Gln Glu Thr Gln Pro Ala Glu Gly Thr Ser Gly 
                85                  90                  95      


Ala Thr Thr Gly Val Val Ala Ala Ser Ser Met Ala Thr Ser Gly Val 
            100                 105                 110         


Leu Pro Gly Gly Gly Phe Val Ala Ser Ala Ala Ala Val Ala Gly Pro 
        115                 120                 125             


Glu Met Gln Thr Gly Arg Asn Asn Phe Val Ile Arg Arg Asn Pro Ala 
    130                 135                 140                 


Asp Pro Gln Arg Ile Pro Ser Asn Pro Ser His Arg Ile Gln Cys Ala 
145                 150                 155                 160 


Ala Gly Tyr Glu Gln Ser Glu His Asn Val Cys Gln Asp Ile Asp Glu 
                165                 170                 175     


Cys Thr Ala Gly Thr His Asn Cys Arg Ala Asp Gln Val Cys Ile Asn 
            180                 185                 190         


Leu Arg Gly Ser Phe Ala Cys Gln Cys Pro Pro Gly Tyr Gln Lys Arg 
        195                 200                 205             


Gly Glu Gln Cys Val Asp Ile Asp Glu Cys Thr Ile Pro Pro Tyr Cys 
    210                 215                 220                 


His Gln Arg Cys Val Asn Thr Pro Gly Ser Phe Tyr Cys Gln Cys Ser 
225                 230                 235                 240 


Pro Gly Phe Gln Leu Ala Ala Asn Asn Tyr Thr Cys Val Asp Ile Asn 
                245                 250                 255     


Glu Cys Asp Ala Ser Asn Gln Cys Ala Gln Gln Cys Tyr Asn Ile Leu 
            260                 265                 270         


Gly Ser Phe Ile Cys Gln Cys Asn Gln Gly Tyr Glu Leu Ser Ser Asp 
        275                 280                 285             


Arg Leu Asn Cys Glu Asp Ile Asp Glu Cys Arg Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Cys Gln Tyr Gln Cys Val Asn Glu Pro Gly Lys Phe Ser Cys Met Cys 
305                 310                 315                 320 


Pro Gln Gly Tyr Gln Val Val Arg Ser Arg Thr Cys Gln Asp Ile Asn 
                325                 330                 335     


Glu Cys Glu Thr Thr Asn Glu Cys Arg Glu Asp Glu Met Cys Trp Asn 
            340                 345                 350         


Tyr His Gly Gly Phe Arg Cys Tyr Pro Arg Asn Pro Cys Gln Asp Pro 
        355                 360                 365             


Tyr Ile Leu Thr Pro Glu Asn Arg Cys Val Cys Pro Val Ser Asn Ala 
    370                 375                 380                 


Met Cys Arg Glu Leu Pro Gln Ser Ile Val Tyr Lys Tyr Met Ser Ile 
385                 390                 395                 400 


Arg Ser Asp Arg Ser Val Pro Ser Asp Ile Phe Gln Ile Gln Ala Thr 
                405                 410                 415     


Thr Ile Tyr Ala Asn Thr Ile Asn Thr Phe Arg Ile Lys Ser Gly Asn 
            420                 425                 430         


Glu Asn Gly Glu Phe Tyr Leu Arg Gln Thr Ser Pro Val Ser Ala Met 
        435                 440                 445             


Leu Val Leu Val Lys Ser Leu Ser Gly Pro Arg Glu His Ile Val Asp 
    450                 455                 460                 


Leu Glu Met Leu Thr Val Ser Ser Ile Gly Thr Phe Arg Thr Ser Ser 
465                 470                 475                 480 


Val Leu Arg Leu Thr Ile Ile Val Gly Pro Phe Ser Phe 
                485                 490             


<210>  59
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
            20                  25                  30          


Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
        35                  40                  45              


Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
    50                  55                  60                  


Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
65                  70                  75                  80  


Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                85                  90                  95      


His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
            100                 105                 110         


Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
        115                 120                 125             


Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
    130                 135                 140                 


Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
145                 150                 155                 160 


Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                165                 170                 175     


Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
            180                 185                 190         


Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
        195                 200                 205             


Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
    210                 215                 220                 


Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
225                 230                 235                 240 


Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                245                 250                 255     


Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
            260                 265                 270         


Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
        275                 280                 285             


Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
    290                 295                 300                 


Thr Lys Glu Ile 
305             


<210>  60
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  61
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Ala Leu Thr Arg Asp Pro Gln Phe Gln Lys Leu Gln Gln Trp 
1               5                   10                  15      


Tyr Arg Glu His Arg Ser Glu Leu Asn Leu Arg Arg Leu Phe Asp Ala 
            20                  25                  30          


Asn Lys Asp Arg Phe Asn His Phe Ser Leu Thr Leu Asn Thr Asn His 
        35                  40                  45              


Gly His Ile Leu Val Asp Tyr Ser Lys Asn Leu Val Thr Glu Asp Val 
    50                  55                  60                  


Met Arg Met Leu Val Asp Leu Ala Lys Ser Arg Gly Val Glu Ala Ala 
65                  70                  75                  80  


Arg Glu Arg Met Phe Asn Gly Glu Lys Ile Asn Tyr Thr Glu Gly Arg 
                85                  90                  95      


Ala Val Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu 
            100                 105                 110         


Val Asp Gly Lys Asp Val Met Pro Glu Val Asn Lys Val Leu Asp Lys 
        115                 120                 125             


Met Lys Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr 
    130                 135                 140                 


Thr Gly Lys Thr Ile Thr Asp Val Ile Asn Ile Gly Ile Gly Gly Ser 
145                 150                 155                 160 


Asp Leu Gly Pro Leu Met Val Thr Glu Ala Leu Lys Pro Tyr Ser Ser 
                165                 170                 175     


Gly Gly Pro Arg Val Trp Tyr Val Ser Asn Ile Asp Gly Thr His Ile 
            180                 185                 190         


Ala Lys Thr Leu Ala Gln Leu Asn Pro Glu Ser Ser Leu Phe Ile Ile 
        195                 200                 205             


Ala Ser Lys Thr Phe Thr Thr Gln Glu Thr Ile Thr Asn Ala Glu Thr 
    210                 215                 220                 


Ala Lys Glu Trp Phe Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala 
225                 230                 235                 240 


Lys His Phe Val Ala Leu Ser Thr Asn Thr Thr Lys Val Lys Glu Phe 
                245                 250                 255     


Gly Ile Asp Pro Gln Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly 
            260                 265                 270         


Arg Tyr Ser Leu Trp Ser Ala Ile Gly Leu Ser Ile Ala Leu His Val 
        275                 280                 285             


Gly Phe Asp Asn Phe Glu Gln Leu Leu Ser Gly Ala His Trp Met Asp 
    290                 295                 300                 


Gln His Phe Arg Thr Thr Pro Leu Glu Lys Asn Ala Pro Val Leu Leu 
305                 310                 315                 320 


Ala Leu Leu Gly Ile Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His 
                325                 330                 335     


Ala Met Leu Pro Tyr Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe 
            340                 345                 350         


Gln Gln Gly Asp Met Glu Ser Asn Gly Lys Tyr Ile Thr Lys Ser Gly 
        355                 360                 365             


Thr Arg Val Asp His Gln Thr Gly Pro Ile Val Trp Gly Glu Pro Gly 
    370                 375                 380                 


Thr Asn Gly Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys 
385                 390                 395                 400 


Met Ile Pro Cys Asp Phe Leu Ile Pro Val Gln Thr Gln His Pro Ile 
                405                 410                 415     


Arg Lys Gly Leu His His Lys Ile Leu Leu Ala Asn Phe Leu Ala Gln 
            420                 425                 430         


Thr Glu Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu 
        435                 440                 445             


Leu Gln Ala Ala Gly Lys Ser Pro Glu Asp Leu Glu Arg Leu Leu Pro 
    450                 455                 460                 


His Lys Val Phe Glu Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr 
465                 470                 475                 480 


Lys Leu Thr Pro Phe Met Leu Gly Ala Leu Val Ala Met Tyr Glu His 
                485                 490                 495     


Lys Ile Phe Val Gln Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp Gln 
            500                 505                 510         


Trp Gly Val Glu Leu Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu 
        515                 520                 525             


Leu Asp Gly Ser Ala Gln Val Thr Ser His Asp Ala Ser Thr Asn Gly 
    530                 535                 540                 


Leu Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala Arg Val Gln 
545                 550                 555             


<210>  62
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  63
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Pro Pro Cys Ser Gly Gly Asp Gly Ser Thr Pro Pro Gly Pro Ser 
1               5                   10                  15      


Leu Arg Asp Arg Asp Cys Pro Ala Gln Ser Ala Glu Tyr Pro Arg Asp 
            20                  25                  30          


Arg Leu Asp Pro Arg Pro Gly Ser Pro Ser Glu Ala Ser Ser Pro Pro 
        35                  40                  45              


Phe Leu Arg Ser Arg Ala Pro Val Asn Trp Tyr Gln Glu Lys Ala Gln 
    50                  55                  60                  


Val Phe Leu Trp His Leu Leu Val Ser Gly Ser Thr Thr Leu Leu Cys 
65                  70                  75                  80  


Leu Trp Lys Gln Pro Phe His Val Ser Ala Phe Pro Val Thr Ala Ser 
                85                  90                  95      


Leu Ala Phe Arg Gln Ser Gln Gly Ala Gly Gln His Leu Tyr Lys Asp 
            100                 105                 110         


Leu Gln Pro Phe Ile Leu Leu Arg Leu Leu Met Pro Glu Glu Thr Gln 
        115                 120                 125             


Thr Gln Asp Gln Pro Met Glu Glu Glu Glu Val Glu Thr Phe Ala Phe 
    130                 135                 140                 


Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe Tyr 
145                 150                 155                 160 


Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ser Ser Asp 
                165                 170                 175     


Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys Leu 
            180                 185                 190         


Asp Ser Gly Arg Glu Leu His Ile Asn Leu Ile Pro Asn Lys Gln Gly 
        195                 200                 205             


Arg Thr Leu Thr Ile Val Asp Thr Gly Ile Gly Met Thr Lys Ala Asp 
    210                 215                 220                 


Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala Phe 
225                 230                 235                 240 


Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln Phe 
                245                 250                 255     


Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Thr Val 
            260                 265                 270         


Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser Ala 
        275                 280                 285             


Gly Gly Ser Phe Thr Val Arg Thr Asp Thr Gly Glu Pro Met Gly Arg 
    290                 295                 300                 


Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr Leu 
305                 310                 315                 320 


Glu Glu Arg Arg Ile Lys Glu Ile Val Lys Lys His Ser Gln Phe Ile 
                325                 330                 335     


Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys Glu Arg Asp Lys Glu Val 
            340                 345                 350         


Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys Glu 
        355                 360                 365             


Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro Glu Ile Glu Asp Val Gly 
    370                 375                 380                 


Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys Lys 
385                 390                 395                 400 


Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys 
                405                 410                 415     


Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly 
            420                 425                 430         


Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val 
        435                 440                 445             


Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe 
    450                 455                 460                 


Val Pro Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Arg Lys Lys Lys 
465                 470                 475                 480 


Asn Asn Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Asn Cys 
                485                 490                 495     


Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp 
            500                 505                 510         


Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser 
        515                 520                 525             


Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val Lys Lys Cys Leu Glu 
    530                 535                 540                 


Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr 
545                 550                 555                 560 


Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile His Glu Asp Ser Gln 
                565                 570                 575     


Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr Tyr Thr Ser Ala Ser 
            580                 585                 590         


Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys Thr Arg Met Lys Glu 
        595                 600                 605             


Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu Thr Lys Asp Gln Val 
    610                 615                 620                 


Ala Asn Ser Ala Phe Val Glu Arg Leu Arg Lys His Gly Leu Glu Val 
625                 630                 635                 640 


Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys 
                645                 650                 655     


Glu Phe Glu Gly Lys Thr Leu Val Ser Val Thr Lys Glu Gly Leu Glu 
            660                 665                 670         


Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys Gln Glu Glu Lys Lys Thr 
        675                 680                 685             


Lys Phe Glu Asn Leu Cys Lys Ile Met Lys Asp Ile Leu Glu Lys Lys 
    690                 695                 700                 


Val Glu Lys Val Val Val Ser Asn Arg Leu Val Thr Ser Pro Cys Cys 
705                 710                 715                 720 


Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met 
                725                 730                 735     


Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Ala Ala 
            740                 745                 750         


Lys Lys His Leu Glu Ile Asn Pro Asp His Ser Ile Ile Glu Thr Leu 
        755                 760                 765             


Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp Lys Ser Val Lys Asp Leu 
    770                 775                 780                 


Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu 
785                 790                 795                 800 


Glu Asp Pro Gln Thr His Ala Asn Arg Ile Tyr Arg Met Ile Lys Leu 
                805                 810                 815     


Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr Ala Asp Asp Thr Ser Ala 
            820                 825                 830         


Ala Val Thr Glu Glu Met Pro Pro Leu Glu Gly Asp Asp Asp Thr Ser 
        835                 840                 845             


Arg Met Glu Glu Val Asp 
    850                 


<210>  64
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  64

Ser Cys Ala Arg Gly Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg 
1               5                   10                  15      


Ala Val Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met 
            20                  25                  30          


Val Gly Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser 
        35                  40                  45              


Lys Arg Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val 
    50                  55                  60                  


Thr Asn Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn 
65                  70                  75                  80  


Glu Leu Arg Val Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala 
                85                  90                  95      


Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe 
            100                 105                 110         


Glu Thr Phe Asn Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu 
        115                 120                 125             


Ser Leu Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly 
    130                 135                 140                 


Asp Gly Val Thr His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro 
145                 150                 155                 160 


His Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr 
                165                 170                 175     


Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala 
            180                 185                 190         


Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala 
        195                 200                 205             


Leu Asp Phe Glu Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu 
    210                 215                 220                 


Glu Lys Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn 
225                 230                 235                 240 


Glu Arg Phe Arg Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly 
                245                 250                 255     


Met Glu Ser Cys Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys 
            260                 265                 270         


Cys Asp Val Asp Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser 
        275                 280                 285             


Gly Gly Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu 
    290                 295                 300                 


Ile Thr Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro 
305                 310                 315                 320 


Pro Glu Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser 
                325                 330                 335     


Leu Ser Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu 
            340                 345                 350         


Ser Gly Pro Ser Ile Val His Arg Lys Cys Phe 
        355                 360             


<210>  65
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210>  66
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Glu Gly Ala Glu Leu 
        275                 280         


<210>  67
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  


Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         


Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser 
        115                 120                 125             


Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu 
                165                 170                 175     


Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly 
        195                 200                 205             


Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys 
    210                 215                 220                 


Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 


Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val 
    290                 295                 300                 


Lys Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala 
305                 310                 315                 320 


Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330         


<210>  68
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  68

Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Met Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210>  69
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  69

Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
1               5                   10                  15      


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
            20                  25                  30          


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
        35                  40                  45              


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
    50                  55                  60                  


Asp Val Asp His Val Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
65                  70                  75                  80  


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
                85                  90                  95      


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
            100                 105                 110         


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
        115                 120                 125             


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
    130                 135                 140                 


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
145                 150                 155                 160 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
                165                 170                 175     


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asn Asp Ile Asp Gly Ile 
            180                 185                 190         


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
        195                 200                 205             


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
    210                 215                 220                 


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
225                 230                 235                 240 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
                245                 250                 255     


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
            260                 265                 270         


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
        275                 280                 285             


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
    290                 295                 300                 


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
305                 310                 315                 320 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
                325                 330                 335     


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
            340                 345                 350         


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
        355                 360                 365             


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
    370                 375                 380                 


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
385                 390                 395                 400 


Asn Cys Arg Lys Asn 
                405 


<210>  70
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
1               5                   10                  15      


Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
            20                  25                  30          


Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
        35                  40                  45              


Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
    50                  55                  60                  


Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                85                  90                  95      


Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
            100                 105                 110         


Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala 
    130                 135                 140                 


Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala 
145                 150                 155                 160 


Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp 
                165                 170                 175     


Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val 
            180                 185                 190         


Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn 
        195                 200                 205             


Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly 
    210                 215                 220                 


Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly 
225                 230                 235                 240 


Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu 
                245                 250                 255     


Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val 
            260                 265                 270         


Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp 
        275                 280                 285             


Gln Trp Arg Lys Ser Leu 
    290                 


<210>  71
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Thr Met Ala Asn Leu 
    130                 135                 140                 


Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu 
145                 150                 155                 160 


Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val 
                165                 170                 175     


Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu Lys Gln His Tyr 
            180                 185                 190         


Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu Val Lys Tyr Met 
        195                 200                 205             


Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val 
    210                 215                 220                 


Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys 
225                 230                 235                 240 


Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile 
                245                 250                 255     


Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys Glu Ile Ser Leu 
            260                 265                 270         


Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser Cys Ala His Asp 
        275                 280                 285             


Trp Val Tyr Glu 
    290         


<210>  72
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Arg Leu Pro Gly Val Pro Leu Ala Arg Pro Ala Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Leu Ala Pro Leu Leu Gly Thr Gly Ala Pro Ala Glu Leu 
            20                  25                  30          


Arg Val Arg Val Arg Leu Pro Asp Gly Gln Val Thr Glu Glu Ser Leu 
        35                  40                  45              


Gln Ala Asp Ser Asp Ala Asp Ser Ile Ser Leu Glu Leu Arg Lys Pro 
    50                  55                  60                  


Asp Gly Thr Leu Val Ser Phe Thr Ala Asp Phe Lys Lys Asp Val Lys 
65                  70                  75                  80  


Val Phe Arg Ala Leu Ile Leu Gly Glu Leu Glu Lys Gly Gln Ser Gln 
                85                  90                  95      


Phe Gln Ala Leu Cys Phe Val Thr Gln Leu Gln His Asn Glu Ile Ile 
            100                 105                 110         


Pro Ser Glu Ala Met Ala Lys Leu Arg Gln Lys Asn Pro Arg Ala Val 
        115                 120                 125             


Arg Gln Ala Glu Glu Val Arg Gly Leu Glu His Leu His Met Asp Val 
    130                 135                 140                 


Ala Val Asn Phe Ser Gln Gly Ala Leu Leu Ser Pro His Leu His Asn 
145                 150                 155                 160 


Val Cys Ala Glu Ala Val Asp Ala Ile Tyr Thr Arg Gln Glu Asp Val 
                165                 170                 175     


Arg Phe Trp Leu Glu Gln Gly Val Asp Ser Ser Val Phe Glu Ala Leu 
            180                 185                 190         


Pro Lys Ala Ser Glu Gln Ala Glu Leu Pro Arg Cys Arg Gln Val Gly 
        195                 200                 205             


Asp His Gly Lys Pro Cys Val Cys Arg Tyr Gly Leu Ser Leu Ala Trp 
    210                 215                 220                 


Tyr Pro Cys Met Leu Lys Tyr Cys His Ser Arg Asp Arg Pro Thr Pro 
225                 230                 235                 240 


Tyr Lys Cys Gly Ile Arg Ser Cys Gln Lys Ser Tyr Ser Phe Asp Phe 
                245                 250                 255     


Tyr Val Pro Gln Arg Gln Leu Cys Leu Trp Asp Glu Asp Pro Tyr Pro 
            260                 265                 270         


Gly 
    


<210>  73
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  74
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly 
1               5                   10                  15      


Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn 
            20                  25                  30          


Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys 
        35                  40                  45              


Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu 
    50                  55                  60                  


Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro 
65                  70                  75                  80  


Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu 
                85                  90                  95      


Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala 
            100                 105                 110         


Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu 
        115                 120                 125             


Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro 
    130                 135                 140                 


Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val 
145                 150                 155                 160 


Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met 
                165                 170                 175     


Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys 
            180                 185                 190         


Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe 
        195                 200                 205             


Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile 
    210                 215                 220                 


Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met 
225                 230                 235                 240 


Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser 
                245                 250                 255     


Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys 
            260                 265                 270         


Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr 
        275                 280                 285             


Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala 
    290                 295                 300                 


Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser 
305                 310                 315                 320 


Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp 
                325                 330                 335     


Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr 
            340                 345                 350         


Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile 
        355                 360                 365             


Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn 
    370                 375                 380                 


Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu 
385                 390                 395                 400 


Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn 
                405                 410                 415     


Ile 
    


<210>  75
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Ala Asp Phe Leu Val Thr Glu Val Glu Asn Gly Gly Ser Leu Gly 
1               5                   10                  15      


Ser Lys Lys Gly Val Asn Leu Pro Gly Ala Ala Val Asp Leu Pro Ala 
            20                  25                  30          


Val Ser Glu Lys Asp Ile Gln Asp Leu Lys Phe Gly Val Glu Gln Asp 
        35                  40                  45              


Val Asp Met Val Phe Ala Ser Phe Ile Arg Lys Ala Ser Asp Val His 
    50                  55                  60                  


Glu Val Arg Lys Val Leu Gly Glu Lys Gly Lys Asn Ile Lys Ile Ile 
65                  70                  75                  80  


Ser Lys Ile Glu Asn His Glu Gly Val Arg Arg Phe Asp Glu Ile Leu 
                85                  90                  95      


Glu Ala Ser Asp Gly Ile Met Val Ala Arg Gly Asp Leu Gly Ile Glu 
            100                 105                 110         


Ile Pro Ala Glu Lys Val Phe Leu Ala Gln Lys Met Met Ile Gly Arg 
        115                 120                 125             


Cys Asn Arg Ala Gly Lys Pro Val Ile Cys Ala Thr Gln Met Leu Glu 
    130                 135                 140                 


Ser Met Ile Lys Lys Pro Arg Pro Thr Arg Ala Glu Gly Ser Asp Val 
145                 150                 155                 160 


Ala Asn Ala Val Leu Asp Gly Ala Asp Cys Ile Met Leu Ser Gly Glu 
                165                 170                 175     


Thr Ala Lys Gly Asp Tyr Pro Leu Glu Ala Val Arg Met Gln His Leu 
            180                 185                 190         


Ile Ala Arg Glu Ala Glu Ala Ala Ile Tyr His Leu Gln Leu Phe Glu 
        195                 200                 205             


Glu Leu Arg Arg Leu Ala Pro Ile Thr Ser Asp Pro Thr Glu Ala Thr 
    210                 215                 220                 


Ala Val Gly Ala Val Glu Ala Ser Phe Lys Cys Cys Ser Gly Ala Ile 
225                 230                 235                 240 


Ile Val Leu Thr Lys Ser Gly Arg Ser Ala His Gln Val Ala Arg Tyr 
                245                 250                 255     


Arg Pro Arg Ala Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala 
            260                 265                 270         


Arg Gln Ala His Leu Tyr Arg Gly Ile Phe Pro Val Leu Cys Lys Asp 
        275                 280                 285             


Pro Val Gln Glu Ala Trp Ala Glu Asp Val Asp Leu Arg Val Asn Phe 
    290                 295                 300                 


Ala Met Asn Val Gly Lys Ala Arg Gly Phe Phe Lys Lys Gly Asp Val 
305                 310                 315                 320 


Val Ile Val Leu Thr Gly Trp Arg Pro Gly Ser Gly Phe Thr Asn Thr 
                325                 330                 335     


Met Arg Val Val Pro Val Pro 
            340             


<210>  76
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr Gln Ser Ser 
        115                 120                 125             


Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His Pro Tyr Glu 
    130                 135                 140                 


Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn Phe Pro Tyr 
145                 150                 155                 160 


Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp Ser Ile Thr 
                165                 170                 175     


Val Leu Pro 
            


<210>  77
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Arg Val Ala Gly Ala Ala Lys Leu Val Val Ala Val Ala Val Phe 
1               5                   10                  15      


Leu Leu Thr Phe Tyr Val Ile Ser Gln Val Phe Glu Ile Lys Met Asp 
            20                  25                  30          


Ala Ser Leu Gly Asn Leu Phe Ala Arg Ser Ala Leu Asp Thr Ala Ala 
        35                  40                  45              


Arg Ser Thr Lys Pro Pro Arg Tyr Lys Cys Gly Ile Ser Lys Ala Cys 
    50                  55                  60                  


Pro Glu Lys His Phe Ala Phe Lys Met Ala Ser Gly Ala Ala Asn Val 
65                  70                  75                  80  


Val Gly Pro Lys Ile Cys Leu Glu Asp Asn Val Leu Met Ser Gly Val 
                85                  90                  95      


Lys Asn Asn Val Gly Arg Gly Ile Asn Val Ala Leu Ala Asn Gly Lys 
            100                 105                 110         


Thr Gly Glu Val Leu Asp Thr Lys Tyr Phe Asp Met Trp Gly Gly Asp 
        115                 120                 125             


Val Ala Pro Phe Ile Glu Phe Leu Lys Ala Ile Gln Asp Gly Thr Ile 
    130                 135                 140                 


Val Leu Met Gly Thr Tyr Asp Asp Gly Ala Thr Lys Leu Asn Asp Glu 
145                 150                 155                 160 


Ala Arg Arg Leu Ile Ala Asp Leu Gly Ser Thr Ser Ile Thr Asn Leu 
                165                 170                 175     


Gly Phe Arg Asp Asn Trp Val Phe Cys Gly Gly Lys Gly Ile Lys Thr 
            180                 185                 190         


Lys Ser Pro Phe Glu Gln His Ile Lys Asn Asn Lys Asp Thr Asn Lys 
        195                 200                 205             


Tyr Glu Gly Trp Pro Glu Val Val Glu Met Glu Gly Cys Ile Pro Gln 
    210                 215                 220                 


Lys Gln Asp 
225         


<210>  78
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210>  79
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ala Lys Lys Arg 
65                  70                  75                  80  


Lys Lys Lys Ser Tyr Thr Thr Pro Lys Lys Asn Lys His Lys Arg Lys 
                85                  90                  95      


Lys Val Lys Leu Ala Val Leu Lys Tyr Tyr Lys Val Asp Glu Asn Gly 
            100                 105                 110         


Lys Ile Ser Arg Leu Arg Arg Glu Cys Pro Ser Asp Glu Cys Gly Ala 
        115                 120                 125             


Gly Val Phe Met Ala Ser His Phe Asp Arg His Tyr Cys Gly Lys Cys 
    130                 135                 140                 


Cys Leu Thr Tyr Cys Phe Asn Lys Pro Glu Asp Lys 
145                 150                 155     


<210>  80
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Glu Ala Lys Thr His Trp Leu Gly Ala Ala Leu Ser Leu Ile 
1               5                   10                  15      


Pro Leu Ile Phe Leu Ile Ser Gly Ala Glu Ala Ala Ser Phe Gln Arg 
            20                  25                  30          


Asn Gln Leu Leu Gln Lys Glu Pro Asp Leu Arg Leu Glu Asn Val Gln 
        35                  40                  45              


Lys Phe Pro Ser Pro Glu Met Ile Arg Ala Leu Glu Tyr Ile Glu Asn 
    50                  55                  60                  


Leu Arg Gln Gln Ala His Lys Glu Glu Ser Ser Pro Asp Tyr Asn Pro 
65                  70                  75                  80  


Tyr Gln Gly Val Ser Val Pro Leu Gln Gln Lys Glu Asn Gly Asp Glu 
                85                  90                  95      


Ser His Leu Pro Glu Arg Asp Ser Leu Ser Glu Glu Asp Trp Met Arg 
            100                 105                 110         


Ile Ile Leu Glu Ala Leu Arg Gln Ala Glu Asn Glu Pro Gln Ser Ala 
        115                 120                 125             


Pro Lys Glu Asn Lys Pro Tyr Ala Leu Asn Ser Glu Lys Asn Phe Pro 
    130                 135                 140                 


Met Asp Met Ser Asp Asp Tyr Glu Thr Gln Gln Trp Pro Glu Arg Lys 
145                 150                 155                 160 


Leu Lys His Met Gln Phe Pro Pro Met Tyr Glu Glu Asn Ser Arg Asp 
                165                 170                 175     


Asn Pro Phe Lys Arg Thr Asn Glu Ile Val Glu Glu Gln Tyr Thr Pro 
            180                 185                 190         


Gln Ser Leu Ala Thr Leu Glu Ser Val Phe Gln Glu Leu Gly Lys Leu 
        195                 200                 205             


Thr Gly Pro Asn Asn Gln Lys Arg Glu Arg Met Asp Glu Glu Gln Lys 
    210                 215                 220                 


Leu Tyr Thr Asp Asp Glu Asp Asp Ile Tyr Lys Ala Asn Asn Ile Ala 
225                 230                 235                 240 


Tyr Glu Asp Val Val Gly Gly Glu Asp Trp Asn Pro Val Glu Glu Lys 
                245                 250                 255     


Ile Glu Ser Gln Thr Gln Glu Glu Val Arg Asp Ser Lys Glu Asn Ile 
            260                 265                 270         


Glu Lys Asn Glu Gln Ile Asn Asp Glu Met Lys Arg Ser Gly Gln Leu 
        275                 280                 285             


Gly Ile Gln Glu Glu Asp Leu Arg Lys Glu Ser Lys Asp Gln Leu Ser 
    290                 295                 300                 


Asp Asp Val Ser Lys Val Ile Ala Tyr Leu Lys Arg Leu Val Asn Ala 
305                 310                 315                 320 


Ala Gly Ser Gly Arg Leu Gln Asn Gly Gln Asn Gly Glu Arg Ala Thr 
                325                 330                 335     


Arg Leu Phe Glu Lys Pro Leu Asp Ser Gln Ser Ile Tyr Gln Leu Ile 
            340                 345                 350         


Glu Ile Ser Arg Asn Leu Gln Ile Pro Pro Glu Asp Leu Ile Glu Met 
        355                 360                 365             


Leu Lys Thr Gly Glu Lys Pro Asn Gly Ser Val Glu Pro Glu Arg Glu 
    370                 375                 380                 


Leu Asp Leu Pro Val Asp Leu Asp Asp Ile Ser Glu Ala Asp Leu Asp 
385                 390                 395                 400 


His Pro Asp Leu Phe Gln Asn Arg Met Leu Ser Lys Ser Gly Tyr Pro 
                405                 410                 415     


Lys Thr Pro Gly Arg Ala Gly Thr Glu Ala Leu Pro Asp Gly Leu Ser 
            420                 425                 430         


Val Glu Asp Ile Leu Asn Leu Leu Gly Met Glu Ser Ala Ala Asn Gln 
        435                 440                 445             


Lys Thr Ser Tyr Phe Pro Asn Pro Tyr Asn Gln Glu Lys Val Leu Pro 
    450                 455                 460                 


Arg Leu Pro Tyr Gly Ala Gly Arg Ser Arg Ser Asn Gln Leu Pro Lys 
465                 470                 475                 480 


Ala Ala Trp Ile Pro His Val Glu Asn Arg Gln Met Ala Tyr Glu Asn 
                485                 490                 495     


Leu Asn Asp Lys Asp Gln Glu Leu Gly Glu Tyr Leu Ala Arg Met Leu 
            500                 505                 510         


Val Lys Tyr Pro Glu Ile Ile Asn Ser Asn Gln Val Lys Arg Val Pro 
        515                 520                 525             


Gly Gln Gly Ser Ser Glu Asp Asp Leu Gln Glu Glu Glu Gln Ile Glu 
    530                 535                 540                 


Gln Ala Ile Lys Glu His Leu Asn Gln Gly Ser Ser Gln Glu Thr Asp 
545                 550                 555                 560 


Lys Leu Ala Pro Val Ser Lys Arg Phe Pro Val Gly Pro Pro Lys Asn 
                565                 570                 575     


Asp Asp Thr Pro Asn Arg Gln Tyr Trp Asp Glu Asp Leu Leu Met Lys 
            580                 585                 590         


Val Leu Glu Tyr Leu Asn Gln Glu Lys Ala Glu Lys Gly Arg Glu His 
        595                 600                 605             


Ile Ala Lys Arg Ala Met Glu Asn Met 
    610                 615         


<210>  81
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Ala Pro Gln Gln Glu Ala Leu Pro Asp Glu Thr Glu Val Val Glu 
            20                  25                  30          


Glu Thr Val Ala Glu Val Thr Glu Val Ser Val Gly Ala Asn Pro Val 
        35                  40                  45              


Gln Val Glu Val Gly Glu Phe Asp Asp Gly Ala Glu Glu Thr Glu Glu 
    50                  55                  60                  


Glu Val Val Ala Glu Asn Pro Cys Gln Asn His His Cys Lys His Gly 
65                  70                  75                  80  


Lys Val Cys Glu Leu Asp Glu Asn Asn Thr Pro Met Cys Val Cys Gln 
                85                  90                  95      


Asp Pro Thr Ser Cys Pro Ala Pro Ile Gly Glu Phe Glu Lys Val Cys 
            100                 105                 110         


Ser Asn Asp Asn Lys Thr Phe Asp Ser Ser Cys His Phe Phe Ala Thr 
        115                 120                 125             


Lys Cys Thr Leu Glu Gly Thr Lys Lys Gly His Lys Leu His Leu Asp 
    130                 135                 140                 


Tyr Ile Gly Pro Cys Lys Tyr Ile Pro Pro Cys Leu Asp Ser Glu Leu 
145                 150                 155                 160 


Thr Glu Phe Pro Leu Arg Met Arg Asp Trp Leu Lys Asn Val Leu Val 
                165                 170                 175     


Thr Leu Tyr Glu Arg Asp Glu Asp Asn Asn Leu Leu Thr Glu Lys Gln 
            180                 185                 190         


Lys Leu Arg Val Lys Lys Ile His Glu Asn Glu Lys Arg Leu Glu Ala 
        195                 200                 205             


Gly Asp His Pro Val Glu Leu Leu Ala Arg Asp Phe Glu Lys Asn Tyr 
    210                 215                 220                 


Asn Met Tyr Ile Phe Pro Val His Trp Gln Phe Gly Gln Leu Asp Gln 
225                 230                 235                 240 


His Pro Ile Asp Gly Tyr Leu Ser His Thr Glu Leu Ala Pro Leu Arg 
                245                 250                 255     


Ala Pro Leu Ile Pro Met Glu His Cys Thr Thr Arg Phe Phe Glu Thr 
            260                 265                 270         


Cys Asp Leu Asp Asn Asp Lys Tyr Ile Ala Leu Asp Glu Trp Ala Gly 
        275                 280                 285             


Cys Phe Gly Ile Lys Gln Lys Asp Ile Asp Lys Asp Leu Val Ile 
    290                 295                 300             


<210>  82
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Gln Ala Ala Trp Pro Leu Gly Ala Leu Val Val Pro Gln Leu Leu 
1               5                   10                  15      


Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly 
            20                  25                  30          


Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu 
        35                  40                  45              


Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu 
    50                  55                  60                  


Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Cys Glu Met Glu Glu 
65                  70                  75                  80  


Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser 
                85                  90                  95      


Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu 
            100                 105                 110         


Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg 
        115                 120                 125             


Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg 
    130                 135                 140                 


Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly 
                165                 170                 175     


Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg 
            180                 185                 190         


Asp Phe Glu Ala Gln Ala Ala Ala Gln Ala Arg Cys Thr Ala Arg Gly 
        195                 200                 205             


Gly Ser Leu Ala Gln Pro Ala Asp Arg Gln Gln Met Glu Ala Leu Thr 
    210                 215                 220                 


Arg Tyr Leu Arg Ala Ala Leu Ala Pro Tyr Asn Trp Pro Val Trp Leu 
225                 230                 235                 240 


Gly Val His Asp Arg Arg Ala Glu Gly Leu Tyr Leu Phe Glu Asn Gly 
                245                 250                 255     


Gln Arg Val Ser Phe Phe Ala Trp His Arg Ser Pro Arg Pro Glu Leu 
            260                 265                 270         


Gly Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp Gln Pro 
        275                 280                 285             


Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp Asp Gly 
    290                 295                 300                 


Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val Cys Glu 
305                 310                 315                 320 


Phe Pro Phe 
            


<210>  83
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  84
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val  Gly Phe Asp Glu Phe  Gly Ser Val 
        995                 1000                 1005             


Asp Phe  Ser Gly Thr Phe Tyr  Val Asn Thr Asp Arg  Asp Asp Asp 
    1010                 1015                 1020             


Tyr Ala  Gly Phe Val Phe Gly  Tyr Gln Ser Ser Ser  Arg Phe Tyr 
    1025                 1030                 1035             


Val Val  Met Trp Lys Gln Val  Thr Gln Thr Tyr Trp  Glu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Arg Ala Tyr Gly Tyr  Ser Gly Val Ser Leu  Lys Val Val 
    1055                 1060                 1065             


Asn Ser  Thr Thr Gly Thr Gly  Glu His Leu Arg Asn  Ala Leu Trp 
    1070                 1075                 1080             


His Thr  Gly Asn Thr Pro Gly  Gln Val Arg Thr Leu  Trp His Asp 
    1085                 1090                 1095             


Pro Arg  Asn Ile Gly Trp Lys  Asp Tyr Thr Ala Tyr  Arg Trp His 
    1100                 1105                 1110             


Leu Thr  His Arg Pro Lys Thr  Gly Tyr Ile Arg Val  Leu Val His 
    1115                 1120                 1125             


Glu Gly  Lys Gln Val Met Ala  Asp Ser Gly Pro Ile  Tyr Asp Gln 
    1130                 1135                 1140             


Thr Tyr  Ala Gly Gly Arg Leu  Gly Leu Phe Val Phe  Ser Gln Glu 
    1145                 1150                 1155             


Met Val  Tyr Phe Ser Asp Leu  Lys Tyr Glu Cys Arg  Asp Ile 
    1160                 1165                 1170         


<210>  85
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  85

Gly Val Gln Gly Trp Arg Glu Asn Leu Cys Glu Glu Arg Glu Gly Ala 
1               5                   10                  15      


Ser Arg Glu Phe Lys Gly Arg Cys Glu Ala Ile Met Asp Ala Met Lys 
            20                  25                  30          


Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly Ala Val Phe Val Ser 
        35                  40                  45              


Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg Gly Ala Arg Ser Tyr 
    50                  55                  60                  


Gln Val Ile Cys Arg Asp Glu Lys Thr Gln Met Ile Tyr Gln Gln His 
65                  70                  75                  80  


Gln Ser Trp Leu Arg Pro Val Leu Arg Ser Asn Arg Val Glu Tyr Cys 
                85                  90                  95      


Trp Cys Asn Ser Gly Arg Ala Gln Cys His Ser Val Pro Val Lys Ser 
            100                 105                 110         


Cys Ser Glu Pro Arg Cys Phe Asn Gly Gly Thr Cys Gln Gln Ala Leu 
        115                 120                 125             


Tyr Phe Ser Asp Phe Val Cys Gln Cys Pro Glu Gly Phe Ala Gly Lys 
    130                 135                 140                 


Cys Cys Glu Ile Asp Thr Arg Ala Thr Cys Tyr Glu Asp Gln Gly Ile 
145                 150                 155                 160 


Ser Tyr Arg Gly Thr Trp Ser Thr Ala Glu Ser Gly Ala Glu Cys Thr 
                165                 170                 175     


Asn Trp Asn Ser Ser Ala Leu Ala Gln Lys Pro Tyr Ser Gly Arg Arg 
            180                 185                 190         


Pro Asp Ala Ile Arg Leu Gly Leu Gly Asn His Asn Tyr Cys Arg Asn 
        195                 200                 205             


Pro Asp Arg Asp Ser Lys Pro Trp Cys Tyr Val Phe Lys Ala Gly Lys 
    210                 215                 220                 


Tyr Ser Ser Glu Phe Cys Ser Thr Pro Ala Cys Ser Glu Gly Asn Ser 
225                 230                 235                 240 


Asp Cys Tyr Phe Gly Asn Gly Ser Ala Tyr Arg Gly Thr His Ser Leu 
                245                 250                 255     


Thr Glu Ser Gly Ala Ser Cys Leu Pro Trp Asn Ser Met Ile Leu Ile 
            260                 265                 270         


Gly Lys Val Tyr Thr Ala Gln Asn Pro Ser Ala Gln Ala Leu Gly Leu 
        275                 280                 285             


Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Lys Pro Trp 
    290                 295                 300                 


Cys His Val Leu Lys Asn Arg Arg Leu Thr Trp Glu Tyr Cys Asp Val 
305                 310                 315                 320 


Pro Ser Cys Ser Thr Cys Gly Leu Arg Gln Tyr Ser Gln Pro Gln Phe 
                325                 330                 335     


Arg Ile Lys Gly Gly Leu Phe Ala Asp Ile Ala Ser His Pro Trp Gln 
            340                 345                 350         


Ala Ala Ile Phe Ala Lys His Arg Arg Ser Pro Gly Glu Arg Phe Leu 
        355                 360                 365             


Cys Gly Gly Ile Leu Ile Ser Ser Cys Trp Ile Leu Ser Ala Ala His 
    370                 375                 380                 


Cys Phe Gln Glu Arg Phe Pro Pro His His Leu Thr Val Ile Leu Gly 
385                 390                 395                 400 


Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Lys Phe Glu Val 
                405                 410                 415     


Glu Lys Tyr Ile Val His Lys Glu Phe Asp Asp Asp Thr Tyr Asp Asn 
            420                 425                 430         


Asp Ile Ala Leu Leu Gln Leu Lys Ser Asp Ser Ser Arg Cys Ala Gln 
        435                 440                 445             


Glu Ser Ser Val Val Arg Thr Val Cys Leu Pro Pro Ala Asp Leu Gln 
    450                 455                 460                 


Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu 
465                 470                 475                 480 


Ala Leu Ser Pro Phe Tyr Ser Glu Arg Leu Lys Glu Ala His Val Arg 
                485                 490                 495     


Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Leu Asn Arg Thr 
            500                 505                 510         


Val Thr Asp Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Pro 
        515                 520                 525             


Gln Ala Asn Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu 
    530                 535                 540                 


Val Cys Leu Asn Asp Gly Arg Met Thr Leu Val Gly Ile Ile Ser Trp 
545                 550                 555                 560 


Gly Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val 
                565                 570                 575     


Thr Asn Tyr Leu Asp Trp Ile Arg Asp Asn Met Arg Pro 
            580                 585                 


<210>  86
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Leu Phe Val Arg Leu Leu Ala Leu Ala Leu Ala Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ala Ala Thr Leu Ala Gly Pro Ala Lys Ser Pro Tyr Gln Leu 
            20                  25                  30          


Val Leu Gln His Ser Arg Leu Arg Gly Arg Gln His Gly Pro Asn Val 
        35                  40                  45              


Cys Ala Val Gln Lys Val Ile Gly Thr Asn Arg Lys Tyr Phe Thr Asn 
    50                  55                  60                  


Cys Lys Gln Trp Tyr Gln Arg Lys Ile Cys Gly Lys Ser Thr Val Ile 
65                  70                  75                  80  


Ser Tyr Glu Cys Cys Pro Gly Tyr Glu Lys Val Pro Gly Glu Lys Gly 
                85                  90                  95      


Cys Pro Ala Ala Leu Pro Leu Ser Asn Leu Tyr Glu Thr Leu Gly Val 
            100                 105                 110         


Val Gly Ser Thr Thr Thr Gln Leu Tyr Thr Asp Arg Thr Glu Lys Leu 
        115                 120                 125             


Arg Pro Glu Met Glu Gly Pro Gly Ser Phe Thr Ile Phe Ala Pro Ser 
    130                 135                 140                 


Asn Glu Ala Trp Ala Ser Leu Pro Ala Glu Val Leu Asp Ser Leu Val 
145                 150                 155                 160 


Ser Asn Val Asn Ile Glu Leu Leu Asn Ala Leu Arg Tyr His Met Val 
                165                 170                 175     


Gly Arg Arg Val Leu Thr Asp Glu Leu Lys His Gly Met Thr Leu Thr 
            180                 185                 190         


Ser Met Tyr Gln Asn Ser Asn Ile Gln Ile His His Tyr Pro Asn Gly 
        195                 200                 205             


Ile Val Thr Val Asn Cys Ala Arg Leu Leu Lys Ala Asp His His Ala 
    210                 215                 220                 


Thr Asn Gly Val Val His Leu Ile Asp Lys Val Ile Ser Thr Ile Thr 
225                 230                 235                 240 


Asn Asn Ile Gln Gln Ile Ile Glu Ile Glu Asp Thr Phe Glu Thr Leu 
                245                 250                 255     


Arg Ala Ala Val Ala Ala Ser Gly Leu Asn Thr Met Leu Glu Gly Asn 
            260                 265                 270         


Gly Gln Tyr Thr Leu Leu Ala Pro Thr Asn Glu Ala Phe Glu Lys Ile 
        275                 280                 285             


Pro Ser Glu Thr Leu Asn Arg Ile Leu Gly Asp Pro Glu Ala Leu Arg 
    290                 295                 300                 


Asp Leu Leu Asn Asn His Ile Leu Lys Ser Ala Met Cys Ala Glu Ala 
305                 310                 315                 320 


Ile Val Ala Gly Leu Ser Val Glu Thr Leu Glu Gly Thr Thr Leu Glu 
                325                 330                 335     


Val Gly Cys Ser Gly Asp Met Leu Thr Ile Asn Gly Lys Ala Ile Ile 
            340                 345                 350         


Ser Asn Lys Asp Ile Leu Ala Thr Asn Gly Val Ile His Tyr Ile Asp 
        355                 360                 365             


Glu Leu Leu Ile Pro Asp Ser Ala Lys Thr Leu Phe Glu Leu Ala Ala 
    370                 375                 380                 


Glu Ser Asp Val Ser Thr Ala Ile Asp Leu Phe Arg Gln Ala Gly Leu 
385                 390                 395                 400 


Gly Asn His Leu Ser Gly Gly Glu Arg Leu Thr Leu Leu Ala Pro Leu 
                405                 410                 415     


Asn Ser Val Phe Lys Asp Gly Thr Pro Pro Ile Asp Ala His Thr Arg 
            420                 425                 430         


Asn Leu Leu Arg Asn His Ile Ile Lys Asp Gln Leu Ala Ser Lys Tyr 
        435                 440                 445             


Leu Tyr His Gly Gln Thr Leu Glu Thr Leu Gly Gly Lys Lys Leu Arg 
    450                 455                 460                 


Val Phe Val Tyr Arg Asn Ser Leu Cys Ile Glu Asn Ser Cys Ile Ala 
465                 470                 475                 480 


Ala His Asp Lys Arg Gly Arg Tyr Gly Thr Leu Phe Thr Met Asp Arg 
                485                 490                 495     


Val Leu Thr Pro Pro Met Gly Thr Val Met Asp Val Leu Lys Gly Asp 
            500                 505                 510         


Asn Arg Phe Ser Met Leu Val Ala Ala Ile Gln Ser Ala Gly Leu Thr 
        515                 520                 525             


Glu Thr Leu Asn Arg Glu Gly Val Tyr Thr Val Phe Ala Pro Thr Asn 
    530                 535                 540                 


Glu Ala Phe Arg Ala Leu Pro Pro Arg Glu Arg Ser Arg Leu Leu Gly 
545                 550                 555                 560 


Asp Ala Lys Glu Leu Ala Asn Ile Leu Lys Tyr His Ile Gly Asp Glu 
                565                 570                 575     


Ile Leu Val Ser Gly Gly Ile Gly Ala Leu Val Arg Leu Lys Ser Leu 
            580                 585                 590         


Gln Gly Asp Lys Leu Glu Val Ser Leu Lys Asn Asn Val Val Ser Val 
        595                 600                 605             


Asn Lys Glu Pro Val Ala Glu Pro Asp Ile Met Ala Thr Asn Gly Val 
    610                 615                 620                 


Val His Val Ile Thr Asn Val Leu Gln Pro Pro Ala Asn Arg Pro Gln 
625                 630                 635                 640 


Glu Arg Gly Asp Glu Leu Ala Asp Ser Ala Leu Glu Ile Phe Lys Gln 
                645                 650                 655     


Ala Ser Ala Phe Ser Arg Ala Ser Gln Arg Ser Val Arg Leu Ala Pro 
            660                 665                 670         


Val Tyr Gln Lys Leu Leu Glu Arg Met Lys His 
        675                 680             


<210>  87
<211>  623
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Glu Ser Tyr His Lys Pro Asp Gln Gln Lys Leu Gln Ala Leu Lys 
1               5                   10                  15      


Asp Thr Ala Asn Arg Leu Arg Ile Ser Ser Ile Gln Ala Thr Thr Ala 
            20                  25                  30          


Ala Gly Ser Gly His Pro Thr Ser Cys Cys Ser Ala Ala Glu Ile Met 
        35                  40                  45              


Ala Val Leu Phe Phe His Thr Met Arg Tyr Lys Ser Gln Asp Pro Arg 
    50                  55                  60                  


Asn Pro His Asn Asp Arg Phe Val Leu Ser Lys Gly His Ala Ala Pro 
65                  70                  75                  80  


Ile Leu Tyr Ala Val Trp Ala Glu Ala Gly Phe Leu Ala Glu Ala Glu 
                85                  90                  95      


Leu Leu Asn Leu Arg Lys Ile Ser Ser Asp Leu Asp Gly His Pro Val 
            100                 105                 110         


Pro Lys Gln Ala Phe Thr Asp Val Ala Thr Gly Ser Leu Gly Gln Gly 
        115                 120                 125             


Leu Gly Ala Ala Cys Gly Met Ala Tyr Thr Gly Lys Tyr Phe Asp Lys 
    130                 135                 140                 


Ala Ser Tyr Arg Val Tyr Cys Leu Leu Gly Asp Gly Glu Leu Ser Glu 
145                 150                 155                 160 


Gly Ser Val Trp Glu Ala Met Ala Phe Ala Ser Ile Tyr Lys Leu Asp 
                165                 170                 175     


Asn Leu Val Ala Ile Leu Asp Ile Asn Arg Leu Gly Gln Ser Asp Pro 
            180                 185                 190         


Ala Pro Leu Gln His Gln Met Asp Ile Tyr Gln Lys Arg Cys Glu Ala 
        195                 200                 205             


Phe Gly Trp His Ala Ile Ile Val Asp Gly His Ser Val Glu Glu Leu 
    210                 215                 220                 


Cys Lys Ala Phe Gly Gln Ala Lys His Gln Pro Thr Ala Ile Ile Ala 
225                 230                 235                 240 


Lys Thr Phe Lys Gly Arg Gly Ile Thr Gly Val Glu Asp Lys Glu Ser 
                245                 250                 255     


Trp His Gly Lys Pro Leu Pro Lys Asn Met Ala Glu Gln Ile Ile Gln 
            260                 265                 270         


Glu Ile Tyr Ser Gln Ile Gln Ser Lys Lys Lys Ile Leu Ala Thr Pro 
        275                 280                 285             


Pro Gln Glu Asp Ala Pro Ser Val Asp Ile Ala Asn Ile Arg Met Pro 
    290                 295                 300                 


Ser Leu Pro Ser Tyr Lys Val Gly Asp Lys Ile Ala Thr Arg Lys Ala 
305                 310                 315                 320 


Tyr Gly Gln Ala Leu Ala Lys Leu Gly His Ala Ser Asp Arg Ile Ile 
                325                 330                 335     


Ala Leu Asp Gly Asp Thr Lys Asn Ser Thr Phe Ser Glu Ile Phe Lys 
            340                 345                 350         


Lys Glu His Pro Asp Arg Phe Ile Glu Cys Tyr Ile Ala Glu Arg Asn 
        355                 360                 365             


Met Val Ser Ile Ala Val Gly Cys Ala Thr Arg Asn Arg Thr Val Pro 
    370                 375                 380                 


Phe Cys Ser Thr Phe Ala Ala Phe Phe Thr Arg Ala Phe Asp Gln Ile 
385                 390                 395                 400 


Arg Met Ala Ala Ile Ser Glu Ser Asn Ile Asn Leu Cys Gly Ser His 
                405                 410                 415     


Cys Gly Val Ser Ile Gly Glu Asp Gly Pro Ser Gln Met Ala Leu Glu 
            420                 425                 430         


Asp Leu Ala Met Phe Arg Ser Val Pro Thr Ser Thr Val Phe Tyr Pro 
        435                 440                 445             


Ser Asp Gly Val Ala Thr Glu Lys Ala Val Glu Leu Ala Ala Asn Thr 
    450                 455                 460                 


Lys Gly Ile Cys Phe Ile Arg Thr Ser Arg Pro Glu Asn Ala Ile Ile 
465                 470                 475                 480 


Tyr Asn Asn Asn Glu Asp Phe Gln Val Gly Gln Ala Lys Val Val Leu 
                485                 490                 495     


Lys Ser Lys Asp Asp Gln Val Thr Val Ile Gly Ala Gly Val Thr Leu 
            500                 505                 510         


His Glu Ala Leu Ala Ala Ala Glu Leu Leu Lys Lys Glu Lys Ile Asn 
        515                 520                 525             


Ile Arg Val Leu Asp Pro Phe Thr Ile Lys Pro Leu Asp Arg Lys Leu 
    530                 535                 540                 


Ile Leu Asp Ser Ala Arg Ala Thr Lys Gly Arg Ile Leu Thr Val Glu 
545                 550                 555                 560 


Asp His Tyr Tyr Glu Gly Gly Ile Gly Glu Ala Val Ser Ser Ala Val 
                565                 570                 575     


Val Gly Glu Pro Gly Ile Thr Val Thr His Leu Ala Val Asn Arg Val 
            580                 585                 590         


Pro Arg Ser Gly Lys Pro Ala Glu Leu Leu Lys Met Phe Gly Ile Asp 
        595                 600                 605             


Arg Asp Ala Ile Ala Gln Ala Val Arg Gly Leu Ile Thr Lys Ala 
    610                 615                 620             


<210>  88
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Gln Ser Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
1               5                   10                  15      


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
            20                  25                  30          


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
        35                  40                  45              


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
    50                  55                  60                  


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
65                  70                  75                  80  


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
                85                  90                  95      


Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
            100                 105                 110         


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
        115                 120                 125             


Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
    130                 135                 140                 


Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
145                 150                 155                 160 


Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
                165                 170                 175     


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
            180                 185                 190         


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
        195                 200                 205             


Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
    210                 215                 220                 


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
225                 230                 235                 240 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
                245                 250                 255     


Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
            260                 265                 270         


Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
        275                 280                 285             


Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
    290                 295                 300                 


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
305                 310                 315                 320 


Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
                325                 330                 335     


Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
            340                 345                 350         


Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
        355                 360                 365             


Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
    370                 375                 380                 


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
385                 390                 395             


<210>  89
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn 
1               5                   10                  15      


Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala 
            20                  25                  30          


Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr 
        35                  40                  45              


Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala 
    50                  55                  60                  


Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His 
                85                  90                  95      


Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln 
            100                 105                 110         


Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile 
        115                 120                 125             


Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val 
    130                 135                 140                 


Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys 
145                 150                 155                 160 


Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr 
                165                 170                 175     


Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp 
            180                 185                 190         


Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile 
        195                 200                 205             


Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln 
    210                 215                 220                 


Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Phe Val Asp Ile Ile Asn Ala Lys Gln 
                245                 


<210>  90
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gln Val Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys Ile Asp 
1               5                   10                  15      


Ile Asp Pro Glu Glu Thr Val Lys Ala Leu Lys Glu Lys Ile Glu Ser 
            20                  25                  30          


Glu Lys Gly Lys Asp Ala Phe Pro Val Ala Gly Gln Lys Leu Ile Tyr 
        35                  40                  45              


Ala Gly Lys Ile Leu Asn Asp Asp Thr Ala Leu Lys Glu Tyr Lys Ile 
    50                  55                  60                  


Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Pro Lys Ala Val 
65                  70                  75                  80  


Ser Thr Pro Ala Pro Ala Thr Thr Gln Gln Ser Ala Pro Ala Ser Thr 
                85                  90                  95      


Thr Ala Val Thr Ser Ser Thr Thr Thr Thr Val Ala Gln Ala Pro Thr 
            100                 105                 110         


Pro Val Pro Ala Leu Ala Pro Thr Ser Thr Pro Ala Ser Ile Thr Pro 
        115                 120                 125             


Ala Ser Ala Thr Ala Ser Ser Glu Pro Ala Pro Ala Ser Ala Ala Lys 
    130                 135                 140                 


Gln Glu Lys Pro Ala Glu Lys Pro Ala Glu Thr Pro Val Ala Thr Ser 
145                 150                 155                 160 


Pro Thr Ala Thr Asp Ser Thr Ser Gly Asp Ser Ser Arg Ser Asn Leu 
                165                 170                 175     


Phe Glu Asp Ala Thr Ser Ala Leu Val Thr Gly Gln Ser Tyr Glu Asn 
            180                 185                 190         


Met Val Thr Glu Ile Met Ser Met Gly Tyr Glu Arg Glu Gln Val Ile 
        195                 200                 205             


Ala Ala Leu Arg Ala Ser Phe Asn Asn Pro Asp Arg Ala Val Glu Tyr 
    210                 215                 220                 


Leu Leu Met Gly Ile Pro Gly Asp Arg Glu Ser Gln Ala Val Val Asp 
225                 230                 235                 240 


Pro Pro Gln Ala Ala Ser Thr Gly Ala Pro Gln Ser Ser Ala Val Ala 
                245                 250                 255     


Ala Ala Ala Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Ser Ser Gly 
            260                 265                 270         


Gly His Pro Leu Glu Phe Leu Arg Asn Gln Pro Gln Phe Gln Gln Met 
        275                 280                 285             


Arg Gln Ile Ile Gln Gln Asn Pro Ser Leu Leu Pro Ala Leu Leu Gln 
    290                 295                 300                 


Gln Ile Gly Arg Glu Asn Pro Gln Leu Leu Gln Gln Ile Ser Gln His 
305                 310                 315                 320 


Gln Glu His Phe Ile Gln Met Leu Asn Glu Pro Val Gln Glu Ala Gly 
                325                 330                 335     


Gly Gln Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Ala Glu Ala 
            340                 345                 350         


Gly Ser Gly His Met Asn Tyr Ile Gln Val Thr Pro Gln Glu Lys Glu 
        355                 360                 365             


Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Gly Leu Val Ile 
    370                 375                 380                 


Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala Asn Phe 
385                 390                 395                 400 


Leu Leu Gln Gln Asn Phe Asp Glu Asp 
                405                 


<210>  91
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Met Ala Ala Met Ala Thr Ala Arg Val Arg Met Gly Pro Arg Cys 
1               5                   10                  15      


Ala Gln Ala Leu Trp Arg Met Pro Trp Leu Pro Val Phe Leu Ser Leu 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Gln Gln Val Pro Leu Val 
        35                  40                  45              


Leu Trp Ser Ser Asp Arg Asp Leu Trp Ala Pro Ala Ala Asp Thr His 
    50                  55                  60                  


Glu Gly His Ile Thr Ser Asp Leu Gln Leu Ser Thr Tyr Leu Asp Pro 
65                  70                  75                  80  


Ala Leu Glu Leu Gly Pro Arg Asn Val Leu Leu Phe Leu Gln Asp Lys 
                85                  90                  95      


Leu Ser Ile Glu Asp Phe Thr Ala Tyr Gly Gly Val Phe Gly Asn Lys 
            100                 105                 110         


Gln Asp Ser Ala Phe Ser Asn Leu Glu Asn Ala Leu Asp Leu Ala Pro 
        115                 120                 125             


Ser Ser Leu Val Leu Pro Ala Val Asp Trp Tyr Ala Val Ser Thr Leu 
    130                 135                 140                 


Thr Thr Tyr Leu Gln Glu Lys Leu Gly Ala Ser Pro Leu His Val Asp 
145                 150                 155                 160 


Leu Ala Thr Leu Arg Glu Leu Lys Leu Asn Ala Ser Leu Pro Ala Leu 
                165                 170                 175     


Leu Leu Ile Arg Leu Pro Tyr Thr Ala Ser Ser Gly Leu Met Ala Pro 
            180                 185                 190         


Arg Glu Val Leu Thr Gly Asn Asp Glu Val Ile Gly Gln Val Leu Ser 
        195                 200                 205             


Thr Leu Lys Ser Glu Asp Val Pro Tyr Thr Ala Ala Leu Thr Ala Val 
    210                 215                 220                 


Arg Pro Ser Arg Val Ala Arg Asp Val Ala Val Val Ala Gly Gly Leu 
225                 230                 235                 240 


Gly Arg Gln Leu Leu Gln Lys Gln Pro Val Ser Pro Val Ile His Pro 
                245                 250                 255     


Pro Val Ser Tyr Asn Asp Thr Ala Pro Arg Ile Leu Phe Trp Ala Gln 
            260                 265                 270         


Asn Phe Ser Val Ala Tyr Lys Asp Gln Trp Glu Asp Leu Thr Pro Leu 
        275                 280                 285             


Thr Phe Gly Val Gln Glu Leu Asn Leu Thr Gly Ser Phe Trp Asn Asp 
    290                 295                 300                 


Ser Phe Ala Arg Leu Ser Leu Thr Tyr Glu Arg Leu Phe Gly Thr Thr 
305                 310                 315                 320 


Val Thr Phe Lys Phe Ile Leu Ala Asn Arg Leu Tyr Pro Val Ser Ala 
                325                 330                 335     


Arg His Trp Phe Thr Met Glu Arg Leu Glu Val His Ser Asn Gly Ser 
            340                 345                 350         


Val Ala Tyr Phe Asn Ala Ser Gln Val Thr Gly Pro Ser Ile Tyr Ser 
        355                 360                 365             


Phe His Cys Glu Tyr Val Ser Ser Leu Ser Lys Lys Gly Ser Leu Leu 
    370                 375                 380                 


Val Ala Arg Thr Gln Pro Ser Pro Trp Gln Met Met Leu Gln Asp Phe 
385                 390                 395                 400 


Gln Ile Gln Ala Phe Asn Val Met Gly Glu Gln Phe Ser Tyr Ala Ser 
                405                 410                 415     


Asp Cys Ala Ser Phe Phe Ser Pro Gly Ile Trp Met Gly Leu Leu Thr 
            420                 425                 430         


Ser Leu Phe Met Leu Phe Ile Phe Thr Tyr Gly Leu His Met Ile Leu 
        435                 440                 445             


Ser Leu Lys Thr Met Asp Arg Phe Asp Asp His Lys Gly Pro Thr Ile 
    450                 455                 460                 


Ser Leu Thr Gln Ile Val 
465                 470 


<210>  92
<211>  2768
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Leu Val Leu Glu Ile Phe Thr Leu Leu Ala Ser Ile Cys Trp 
1               5                   10                  15      


Val Ser Ala Asn Ile Phe Glu Tyr Gln Val Asp Ala Gln Pro Leu Arg 
            20                  25                  30          


Pro Cys Glu Leu Gln Arg Glu Thr Ala Phe Leu Lys Gln Ala Asp Tyr 
        35                  40                  45              


Val Pro Gln Cys Ala Glu Asp Gly Ser Phe Gln Thr Val Gln Cys Gln 
    50                  55                  60                  


Asn Asp Gly Arg Ser Cys Trp Cys Val Gly Ala Asn Gly Ser Glu Val 
65                  70                  75                  80  


Leu Gly Ser Arg Gln Pro Gly Arg Pro Val Ala Cys Leu Ser Phe Cys 
                85                  90                  95      


Gln Leu Gln Lys Gln Gln Ile Leu Leu Ser Gly Tyr Ile Asn Ser Thr 
            100                 105                 110         


Asp Thr Ser Tyr Leu Pro Gln Cys Gln Asp Ser Gly Asp Tyr Ala Pro 
        115                 120                 125             


Val Gln Cys Asp Val Gln Gln Val Gln Cys Trp Cys Val Asp Ala Glu 
    130                 135                 140                 


Gly Met Glu Val Tyr Gly Thr Arg Gln Leu Gly Arg Pro Lys Arg Cys 
145                 150                 155                 160 


Pro Arg Ser Cys Glu Ile Arg Asn Arg Arg Leu Leu His Gly Val Gly 
                165                 170                 175     


Asp Lys Ser Pro Pro Gln Cys Ser Ala Glu Gly Glu Phe Met Pro Val 
            180                 185                 190         


Gln Cys Lys Phe Val Asn Thr Thr Asp Met Met Ile Phe Asp Leu Val 
        195                 200                 205             


His Ser Tyr Asn Arg Phe Pro Asp Ala Phe Val Thr Phe Ser Ser Phe 
    210                 215                 220                 


Gln Arg Arg Phe Pro Glu Val Ser Gly Tyr Cys His Cys Ala Asp Ser 
225                 230                 235                 240 


Gln Gly Arg Glu Leu Ala Glu Thr Gly Leu Glu Leu Leu Leu Asp Glu 
                245                 250                 255     


Ile Tyr Asp Thr Ile Phe Ala Gly Leu Asp Leu Pro Ser Thr Phe Thr 
            260                 265                 270         


Glu Thr Thr Leu Tyr Arg Ile Leu Gln Arg Arg Phe Leu Ala Val Gln 
        275                 280                 285             


Ser Val Ile Ser Gly Arg Phe Arg Cys Pro Thr Lys Cys Glu Val Glu 
    290                 295                 300                 


Arg Phe Thr Ala Thr Ser Phe Gly His Pro Tyr Val Pro Ser Cys Arg 
305                 310                 315                 320 


Arg Asn Gly Asp Tyr Gln Ala Val Gln Cys Gln Thr Glu Gly Pro Cys 
                325                 330                 335     


Trp Cys Val Asp Ala Gln Gly Lys Glu Met His Gly Thr Arg Gln Gln 
            340                 345                 350         


Gly Glu Pro Pro Ser Cys Ala Glu Gly Gln Ser Cys Ala Ser Glu Arg 
        355                 360                 365             


Gln Gln Ala Leu Ser Arg Leu Tyr Phe Gly Thr Ser Gly Tyr Phe Ser 
    370                 375                 380                 


Gln His Asp Leu Phe Ser Ser Pro Glu Lys Arg Trp Ala Ser Pro Arg 
385                 390                 395                 400 


Val Ala Arg Phe Ala Thr Ser Cys Pro Pro Thr Ile Lys Glu Leu Phe 
                405                 410                 415     


Val Asp Ser Gly Leu Leu Arg Pro Met Val Glu Gly Gln Ser Gln Gln 
            420                 425                 430         


Phe Ser Val Ser Glu Asn Leu Leu Lys Glu Ala Ile Arg Ala Ile Phe 
        435                 440                 445             


Pro Ser Arg Gly Leu Ala Arg Leu Ala Leu Gln Phe Thr Thr Asn Pro 
    450                 455                 460                 


Lys Arg Leu Gln Gln Asn Leu Phe Gly Gly Lys Phe Leu Val Asn Val 
465                 470                 475                 480 


Gly Gln Phe Asn Leu Ser Gly Ala Leu Gly Thr Arg Gly Thr Phe Asn 
                485                 490                 495     


Phe Ser Gln Phe Phe Gln Gln Leu Gly Leu Ala Ser Phe Leu Asn Gly 
            500                 505                 510         


Gly Arg Gln Glu Asp Leu Ala Lys Pro Leu Ser Val Gly Leu Asp Ser 
        515                 520                 525             


Asn Ser Ser Thr Gly Thr Pro Glu Ala Ala Lys Lys Asp Gly Thr Met 
    530                 535                 540                 


Asn Lys Pro Thr Val Gly Ser Phe Gly Phe Glu Ile Asn Leu Gln Glu 
545                 550                 555                 560 


Asn Gln Asn Ala Leu Lys Phe Leu Ala Ser Leu Leu Glu Leu Pro Glu 
                565                 570                 575     


Phe Leu Leu Phe Leu Gln His Ala Ile Ser Val Pro Glu Asp Val Ala 
            580                 585                 590         


Arg Asp Leu Gly Asp Val Met Glu Thr Val Leu Ser Ser Gln Thr Cys 
        595                 600                 605             


Glu Gln Thr Pro Glu Arg Leu Phe Val Pro Ser Cys Thr Thr Glu Gly 
    610                 615                 620                 


Ser Tyr Glu Asp Val Gln Cys Phe Ser Gly Glu Cys Trp Cys Val Asn 
625                 630                 635                 640 


Ser Trp Gly Lys Glu Leu Pro Gly Ser Arg Val Arg Gly Gly Gln Pro 
                645                 650                 655     


Arg Cys Pro Thr Asp Cys Glu Lys Gln Arg Ala Arg Met Gln Ser Leu 
            660                 665                 670         


Met Gly Ser Gln Pro Ala Gly Ser Thr Leu Phe Val Pro Ala Cys Thr 
        675                 680                 685             


Ser Glu Gly His Phe Leu Pro Val Gln Cys Phe Asn Ser Glu Cys Tyr 
    690                 695                 700                 


Cys Val Asp Ala Glu Gly Gln Ala Ile Pro Gly Thr Arg Ser Ala Ile 
705                 710                 715                 720 


Gly Lys Pro Lys Lys Cys Pro Thr Pro Cys Gln Leu Gln Ser Glu Gln 
                725                 730                 735     


Ala Phe Leu Arg Thr Val Gln Ala Leu Leu Ser Asn Ser Ser Met Leu 
            740                 745                 750         


Pro Thr Leu Ser Asp Thr Tyr Ile Pro Gln Cys Ser Thr Asp Gly Gln 
        755                 760                 765             


Trp Arg Gln Val Gln Cys Asn Gly Pro Pro Glu Gln Val Phe Glu Leu 
    770                 775                 780                 


Tyr Gln Arg Trp Glu Ala Gln Asn Lys Gly Gln Asp Leu Thr Pro Ala 
785                 790                 795                 800 


Lys Leu Leu Val Lys Ile Met Ser Tyr Arg Glu Ala Ala Ser Gly Asn 
                805                 810                 815     


Phe Ser Leu Phe Ile Gln Ser Leu Tyr Glu Ala Gly Gln Gln Asp Val 
            820                 825                 830         


Phe Pro Val Leu Ser Gln Tyr Pro Ser Leu Gln Asp Val Pro Leu Ala 
        835                 840                 845             


Ala Leu Glu Gly Lys Arg Pro Gln Pro Arg Glu Asn Ile Leu Leu Glu 
    850                 855                 860                 


Pro Tyr Leu Phe Trp Gln Ile Leu Asn Gly Gln Leu Ser Gln Tyr Pro 
865                 870                 875                 880 


Gly Ser Tyr Ser Asp Phe Ser Thr Pro Leu Ala His Phe Asp Leu Arg 
                885                 890                 895     


Asn Cys Trp Cys Val Asp Glu Ala Gly Gln Glu Leu Glu Gly Met Arg 
            900                 905                 910         


Ser Glu Pro Ser Lys Leu Pro Thr Cys Pro Gly Ser Cys Glu Glu Ala 
        915                 920                 925             


Lys Leu Arg Val Leu Gln Phe Ile Arg Glu Thr Glu Glu Ile Val Ser 
    930                 935                 940                 


Ala Ser Asn Ser Ser Arg Phe Pro Leu Gly Glu Ser Phe Leu Val Ala 
945                 950                 955                 960 


Lys Gly Ile Arg Leu Arg Asn Glu Asp Leu Gly Leu Pro Pro Leu Phe 
                965                 970                 975     


Pro Pro Arg Glu Ala Phe Ala Glu Gln Phe Leu Arg Gly Ser Asp Tyr 
            980                 985                 990         


Ala Ile Arg Leu Ala Ala Gln Ser  Thr Leu Ser Phe Tyr  Gln Arg Arg 
        995                 1000                 1005             


Arg Phe  Ser Pro Asp Asp Ser  Ala Gly Ala Ser Ala  Leu Leu Arg 
    1010                 1015                 1020             


Ser Gly  Pro Tyr Met Pro Gln  Cys Asp Ala Phe Gly  Ser Trp Glu 
    1025                 1030                 1035             


Pro Val  Gln Cys His Ala Gly  Thr Gly His Cys Trp  Cys Val Asp 
    1040                 1045                 1050             


Glu Lys  Gly Gly Phe Ile Pro  Gly Ser Leu Thr Ala  Arg Ser Leu 
    1055                 1060                 1065             


Gln Ile  Pro Gln Cys Pro Thr  Thr Cys Glu Lys Ser  Arg Thr Ser 
    1070                 1075                 1080             


Gly Leu  Leu Ser Ser Trp Lys  Gln Ala Arg Ser Gln  Glu Asn Pro 
    1085                 1090                 1095             


Ser Pro  Lys Asp Leu Phe Val  Pro Ala Cys Leu Glu  Thr Gly Glu 
    1100                 1105                 1110             


Tyr Ala  Arg Leu Gln Ala Ser  Gly Ala Gly Thr Trp  Cys Val Asp 
    1115                 1120                 1125             


Pro Ala  Ser Gly Glu Glu Leu  Arg Pro Gly Ser Ser  Ser Ser Ala 
    1130                 1135                 1140             


Gln Cys  Pro Ser Leu Cys Asn  Val Leu Lys Ser Gly  Val Leu Ser 
    1145                 1150                 1155             


Arg Arg  Val Ser Pro Gly Tyr  Val Pro Ala Cys Arg  Ala Glu Asp 
    1160                 1165                 1170             


Gly Gly  Phe Ser Pro Val Gln  Cys Asp Gln Ala Gln  Gly Ser Cys 
    1175                 1180                 1185             


Trp Cys  Val Met Asp Ser Gly  Glu Glu Val Pro Gly  Thr Arg Val 
    1190                 1195                 1200             


Thr Gly  Gly Gln Pro Ala Cys  Glu Ser Pro Arg Cys  Pro Leu Pro 
    1205                 1210                 1215             


Phe Asn  Ala Ser Glu Val Val  Gly Gly Thr Ile Leu  Cys Glu Thr 
    1220                 1225                 1230             


Ile Ser  Gly Pro Thr Gly Ser  Ala Met Gln Gln Cys  Gln Leu Leu 
    1235                 1240                 1245             


Cys Arg  Gln Gly Ser Trp Ser  Val Phe Pro Pro Gly  Pro Leu Ile 
    1250                 1255                 1260             


Cys Ser  Leu Glu Ser Gly Arg  Trp Glu Ser Gln Leu  Pro Gln Pro 
    1265                 1270                 1275             


Arg Ala  Cys Gln Arg Pro Gln  Leu Trp Gln Thr Ile  Gln Thr Gln 
    1280                 1285                 1290             


Gly His  Phe Gln Leu Gln Leu  Pro Pro Gly Lys Met  Cys Ser Ala 
    1295                 1300                 1305             


Asp Tyr  Ala Asp Leu Leu Gln  Thr Phe Gln Val Phe  Ile Leu Asp 
    1310                 1315                 1320             


Glu Leu  Thr Ala Arg Gly Phe  Cys Gln Ile Gln Val  Lys Thr Phe 
    1325                 1330                 1335             


Gly Thr  Leu Val Ser Ile Pro  Val Cys Asn Asn Ser  Ser Val Gln 
    1340                 1345                 1350             


Val Gly  Cys Leu Thr Arg Glu  Arg Leu Gly Val Asn  Val Thr Trp 
    1355                 1360                 1365             


Lys Ser  Arg Leu Glu Asp Ile  Pro Val Ala Ser Leu  Pro Asp Leu 
    1370                 1375                 1380             


His Asp  Ile Glu Arg Ala Leu  Val Gly Lys Asp Leu  Leu Gly Arg 
    1385                 1390                 1395             


Phe Thr  Asp Leu Ile Gln Ser  Gly Ser Phe Gln Leu  His Leu Asp 
    1400                 1405                 1410             


Ser Lys  Thr Phe Pro Ala Glu  Thr Ile Arg Phe Leu  Gln Gly Asp 
    1415                 1420                 1425             


His Phe  Gly Thr Ser Pro Arg  Thr Trp Phe Gly Cys  Ser Glu Gly 
    1430                 1435                 1440             


Phe Tyr  Gln Val Leu Thr Ser  Glu Ala Ser Gln Asp  Gly Leu Gly 
    1445                 1450                 1455             


Cys Val  Lys Cys Pro Glu Gly  Ser Tyr Ser Gln Asp  Glu Glu Cys 
    1460                 1465                 1470             


Ile Pro  Cys Pro Val Gly Phe  Tyr Gln Glu Gln Ala  Gly Ser Leu 
    1475                 1480                 1485             


Ala Cys  Val Pro Cys Pro Val  Gly Arg Thr Thr Ile  Ser Ala Gly 
    1490                 1495                 1500             


Ala Phe  Ser Gln Thr His Cys  Val Thr Asp Cys Gln  Arg Asn Glu 
    1505                 1510                 1515             


Ala Gly  Leu Gln Cys Asp Gln  Asn Gly Gln Tyr Arg  Ala Ser Gln 
    1520                 1525                 1530             


Lys Asp  Arg Gly Ser Gly Lys  Ala Phe Cys Val Asp  Gly Glu Gly 
    1535                 1540                 1545             


Arg Arg  Leu Pro Trp Trp Glu  Thr Glu Ala Pro Leu  Glu Asp Ser 
    1550                 1555                 1560             


Gln Cys  Leu Met Met Gln Lys  Phe Glu Lys Val Pro  Glu Ser Lys 
    1565                 1570                 1575             


Val Ile  Phe Asp Ala Asn Ala  Pro Val Ala Val Arg  Ser Lys Val 
    1580                 1585                 1590             


Pro Asp  Ser Glu Phe Pro Val  Met Gln Cys Leu Thr  Asp Cys Thr 
    1595                 1600                 1605             


Glu Asp  Glu Ala Cys Ser Phe  Phe Thr Val Ser Thr  Thr Glu Pro 
    1610                 1615                 1620             


Glu Ile  Ser Cys Asp Phe Tyr  Ala Trp Thr Ser Asp  Asn Val Ala 
    1625                 1630                 1635             


Cys Met  Thr Ser Asp Gln Lys  Arg Asp Ala Leu Gly  Asn Ser Lys 
    1640                 1645                 1650             


Ala Thr  Ser Phe Gly Ser Leu  Arg Cys Gln Val Lys  Val Arg Ser 
    1655                 1660                 1665             


His Gly  Gln Asp Ser Pro Ala  Val Tyr Leu Lys Lys  Gly Gln Gly 
    1670                 1675                 1680             


Ser Thr  Thr Thr Leu Gln Lys  Arg Phe Glu Pro Thr  Gly Phe Gln 
    1685                 1690                 1695             


Asn Met  Leu Ser Gly Leu Tyr  Asn Pro Ile Val Phe  Ser Ala Ser 
    1700                 1705                 1710             


Gly Ala  Asn Leu Thr Asp Ala  His Leu Phe Cys Leu  Leu Ala Cys 
    1715                 1720                 1725             


Asp Arg  Asp Leu Cys Cys Asp  Gly Phe Val Leu Thr  Gln Val Gln 
    1730                 1735                 1740             


Gly Gly  Ala Ile Ile Cys Gly  Leu Leu Ser Ser Pro  Ser Val Leu 
    1745                 1750                 1755             


Leu Cys  Asn Val Lys Asp Trp  Met Asp Pro Ser Glu  Ala Trp Ala 
    1760                 1765                 1770             


Asn Ala  Thr Cys Pro Gly Val  Thr Tyr Asp Gln Glu  Ser His Gln 
    1775                 1780                 1785             


Val Ile  Leu Arg Leu Gly Asp  Gln Glu Phe Ile Lys  Ser Leu Thr 
    1790                 1795                 1800             


Pro Leu  Glu Gly Thr Gln Asp  Thr Phe Thr Asn Phe  Gln Gln Val 
    1805                 1810                 1815             


Tyr Leu  Trp Lys Asp Ser Asp  Met Gly Ser Arg Pro  Glu Ser Met 
    1820                 1825                 1830             


Gly Cys  Arg Lys Asp Thr Val  Pro Arg Pro Ala Ser  Pro Thr Glu 
    1835                 1840                 1845             


Ala Gly  Leu Thr Thr Glu Leu  Phe Ser Pro Val Asp  Leu Asn Gln 
    1850                 1855                 1860             


Val Ile  Val Asn Gly Asn Gln  Ser Leu Ser Ser Gln  Lys His Trp 
    1865                 1870                 1875             


Leu Phe  Lys His Leu Phe Ser  Ala Gln Gln Ala Asn  Leu Trp Cys 
    1880                 1885                 1890             


Leu Ser  Arg Cys Val Gln Glu  His Ser Phe Cys Gln  Leu Ala Glu 
    1895                 1900                 1905             


Ile Thr  Glu Ser Ala Ser Leu  Tyr Phe Thr Cys Thr  Leu Tyr Pro 
    1910                 1915                 1920             


Glu Ala  Gln Val Cys Asp Asp  Ile Met Glu Ser Asn  Ala Gln Gly 
    1925                 1930                 1935             


Cys Arg  Leu Ile Leu Pro Gln  Met Pro Lys Ala Leu  Phe Arg Lys 
    1940                 1945                 1950             


Lys Val  Ile Leu Glu Asp Lys  Val Lys Asn Phe Tyr  Thr Arg Leu 
    1955                 1960                 1965             


Pro Phe  Gln Lys Leu Met Gly  Ile Ser Ile Arg Asn  Lys Val Pro 
    1970                 1975                 1980             


Met Ser  Glu Lys Ser Ile Ser  Asn Gly Phe Phe Glu  Cys Glu Arg 
    1985                 1990                 1995             


Arg Cys  Asp Ala Asp Pro Cys  Cys Thr Gly Phe Gly  Phe Leu Asn 
    2000                 2005                 2010             


Val Ser  Gln Leu Lys Gly Gly  Glu Val Thr Cys Leu  Thr Leu Asn 
    2015                 2020                 2025             


Ser Leu  Gly Ile Gln Met Cys  Ser Glu Glu Asn Gly  Gly Ala Trp 
    2030                 2035                 2040             


Arg Ile  Leu Asp Cys Gly Ser  Pro Asp Ile Glu Val  His Thr Tyr 
    2045                 2050                 2055             


Pro Phe  Gly Trp Tyr Gln Lys  Pro Ile Ala Gln Asn  Asn Ala Pro 
    2060                 2065                 2070             


Ser Phe  Cys Pro Leu Val Val  Leu Pro Ser Leu Thr  Glu Lys Val 
    2075                 2080                 2085             


Ser Leu  Asp Ser Trp Gln Ser  Leu Ala Leu Ser Ser  Val Val Val 
    2090                 2095                 2100             


Asp Pro  Ser Ile Arg His Phe  Asp Val Ala His Val  Ser Thr Ala 
    2105                 2110                 2115             


Ala Thr  Ser Asn Phe Ser Ala  Val Arg Asp Leu Cys  Leu Ser Glu 
    2120                 2125                 2130             


Cys Ser  Gln His Glu Ala Cys  Leu Ile Thr Thr Leu  Gln Thr Gln 
    2135                 2140                 2145             


Pro Gly  Ala Val Arg Cys Met  Phe Tyr Ala Asp Thr  Gln Ser Cys 
    2150                 2155                 2160             


Thr His  Ser Leu Gln Gly Gln  Asn Cys Arg Leu Leu  Leu Arg Glu 
    2165                 2170                 2175             


Glu Ala  Thr His Ile Tyr Arg  Lys Pro Gly Ile Ser  Leu Leu Ser 
    2180                 2185                 2190             


Tyr Glu  Ala Ser Val Pro Ser  Val Pro Ile Ser Thr  His Gly Arg 
    2195                 2200                 2205             


Leu Leu  Gly Arg Ser Gln Ala  Ile Gln Val Gly Thr  Ser Trp Lys 
    2210                 2215                 2220             


Gln Val  Asp Gln Phe Leu Gly  Val Pro Tyr Ala Ala  Pro Pro Leu 
    2225                 2230                 2235             


Ala Glu  Arg Arg Phe Gln Ala  Pro Glu Pro Leu Asn  Trp Thr Gly 
    2240                 2245                 2250             


Ser Trp  Asp Ala Ser Lys Pro  Arg Ala Ser Cys Trp  Gln Pro Gly 
    2255                 2260                 2265             


Thr Arg  Thr Ser Thr Ser Pro  Gly Val Ser Glu Asp  Cys Leu Tyr 
    2270                 2275                 2280             


Leu Asn  Val Phe Ile Pro Gln  Asn Val Ala Pro Asn  Ala Ser Val 
    2285                 2290                 2295             


Leu Val  Phe Phe His Asn Thr  Met Asp Arg Glu Glu  Ser Glu Gly 
    2300                 2305                 2310             


Trp Pro  Ala Ile Asp Gly Ser  Phe Leu Ala Ala Val  Gly Asn Leu 
    2315                 2320                 2325             


Ile Val  Val Thr Ala Ser Tyr  Arg Val Gly Val Phe  Gly Phe Leu 
    2330                 2335                 2340             


Ser Ser  Gly Ser Gly Glu Val  Ser Gly Asn Trp Gly  Leu Leu Asp 
    2345                 2350                 2355             


Gln Val  Ala Ala Leu Thr Trp  Val Gln Thr His Ile  Arg Gly Phe 
    2360                 2365                 2370             


Gly Gly  Asp Pro Arg Arg Val  Ser Leu Ala Ala Asp  Arg Gly Gly 
    2375                 2380                 2385             


Ala Asp  Val Ala Ser Ile His  Leu Leu Thr Ala Arg  Ala Thr Asn 
    2390                 2395                 2400             


Ser Gln  Leu Phe Arg Arg Ala  Val Leu Met Gly Gly  Ser Ala Leu 
    2405                 2410                 2415             


Ser Pro  Ala Ala Val Ile Ser  His Glu Arg Ala Gln  Gln Gln Ala 
    2420                 2425                 2430             


Ile Ala  Leu Ala Lys Glu Val  Ser Cys Pro Met Ser  Ser Ser Gln 
    2435                 2440                 2445             


Glu Val  Val Ser Cys Leu Arg  Gln Lys Pro Ala Asn  Val Leu Asn 
    2450                 2455                 2460             


Asp Ala  Gln Thr Lys Leu Leu  Ala Val Ser Gly Pro  Phe His Tyr 
    2465                 2470                 2475             


Trp Gly  Pro Val Ile Asp Gly  His Phe Leu Arg Glu  Pro Pro Ala 
    2480                 2485                 2490             


Arg Ala  Leu Lys Arg Ser Leu  Trp Val Glu Val Asp  Leu Leu Ile 
    2495                 2500                 2505             


Gly Ser  Ser Gln Asp Asp Gly  Leu Ile Asn Arg Ala  Lys Ala Val 
    2510                 2515                 2520             


Lys Gln  Phe Glu Glu Ser Arg  Gly Arg Thr Ser Ser  Lys Thr Ala 
    2525                 2530                 2535             


Phe Tyr  Gln Ala Leu Gln Asn  Ser Leu Gly Gly Glu  Asp Ser Asp 
    2540                 2545                 2550             


Ala Arg  Val Glu Ala Ala Ala  Thr Trp Tyr Tyr Ser  Leu Glu His 
    2555                 2560                 2565             


Ser Thr  Asp Asp Tyr Ala Ser  Phe Ser Arg Ala Leu  Glu Asn Ala 
    2570                 2575                 2580             


Thr Arg  Asp Tyr Phe Ile Ile  Cys Pro Ile Ile Asp  Met Ala Ser 
    2585                 2590                 2595             


Ala Trp  Ala Lys Arg Ala Arg  Gly Asn Val Phe Met  Tyr His Ala 
    2600                 2605                 2610             


Pro Glu  Asn Tyr Gly His Gly  Ser Leu Glu Leu Leu  Ala Asp Val 
    2615                 2620                 2625             


Gln Phe  Ala Leu Gly Leu Pro  Phe Tyr Pro Ala Tyr  Glu Gly Gln 
    2630                 2635                 2640             


Phe Ser  Leu Glu Glu Lys Ser  Leu Ser Leu Lys Ile  Met Gln Tyr 
    2645                 2650                 2655             


Phe Ser  His Phe Ile Arg Ser  Gly Asn Pro Asn Tyr  Pro Tyr Glu 
    2660                 2665                 2670             


Phe Ser  Arg Lys Val Pro Thr  Phe Ala Thr Pro Trp  Pro Asp Phe 
    2675                 2680                 2685             


Val Pro  Arg Ala Gly Gly Glu  Asn Tyr Lys Glu Phe  Ser Glu Leu 
    2690                 2695                 2700             


Leu Pro  Asn Arg Gln Gly Leu  Lys Lys Ala Asp Cys  Ser Phe Trp 
    2705                 2710                 2715             


Ser Lys  Tyr Ile Ser Ser Leu  Lys Thr Ser Ala Asp  Gly Ala Lys 
    2720                 2725                 2730             


Gly Gly  Gln Ser Ala Glu Ser  Glu Glu Glu Glu Leu  Thr Ala Gly 
    2735                 2740                 2745             


Ser Gly  Leu Arg Glu Asp Leu  Leu Ser Leu Gln Glu  Pro Gly Ser 
    2750                 2755                 2760             


Lys Thr  Tyr Ser Lys 
    2765             


<210>  93
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210>  94
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Gly Lys His Phe Ile Ser Leu 
            420                 425                 430     


<210>  95
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  96
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Cys Pro Leu Asp Gln Ala Ile Gly Leu Leu Val Ala Ile Phe 
1               5                   10                  15      


His Lys Tyr Ser Gly Arg Glu Gly Asp Lys His Thr Leu Ser Lys Lys 
            20                  25                  30          


Glu Leu Lys Glu Leu Ile Gln Lys Glu Leu Thr Ile Gly Ser Lys Leu 
        35                  40                  45              


Gln Asp Ala Glu Ile Ala Arg Leu Met Glu Asp Leu Asp Arg Asn Lys 
    50                  55                  60                  


Asp Gln Glu Val Asn Phe Gln Glu Tyr Val Thr Phe Leu Gly Ala Leu 
65                  70                  75                  80  


Ala Leu Ile Tyr Asn Glu Ala Leu Lys Gly 
                85                  90  


<210>  97
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr 
1               5                   10                  15      


Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp 
            20                  25                  30          


Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val 
        35                  40                  45              


Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln 
65                  70                  75                  80  


Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala 
                85                  90                  95      


Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu 
            100                 105                 110         


Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys 
        115                 120                 125             


Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr 
    130                 135                 140 


<210>  98
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210>  99
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


