                         SEQUENCE LISTING

<110>  OncoMed Pharmaceuticals, Inc.
       Zhang, Chun
       Kapoun, Ann M.
 
<120>  IDENTIFICATION OF PREDICTIVE BIOMARKERS ASSOCIATED WITH WNT 
       PATHWAY INHIBITORS

<130>  2293.142PC01/PAC/MIG

<150>  62/174,750
<151>  2015-06-12

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Heavy chain CDR1

<400>  1

Gly Phe Thr Phe Ser His Tyr Thr Leu Ser 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Heavy chain CDR2

<400>  2

Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Heavy chain CDR3

<400>  3

Asn Phe Ile Lys Tyr Val Phe Ala Asn 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Light chain CDR1

<400>  4

Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His 
1               5                   10      


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Light chain CDR2

<400>  5

Asp Lys Ser Asn Arg Pro Ser Gly 
1               5               


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Light chain CDR3

<400>  6

Gln Ser Tyr Ala Asn Thr Leu Ser Leu 
1               5                   


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Heavy chain variable region amino acid sequence

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Light chain variable region amino acid sequence

<400>  8

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  9
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Heavy chain amino acid sequence with predicted signal 
       sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  9

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser His Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  10
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Light chain amino acid sequence with predicted signal 
       sequence


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  10

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala 
            20                  25                  30          


Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser 
        35                  40                  45              


Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr 
                85                  90                  95      


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr 
            100                 105                 110         


Leu Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
        115                 120                 125             


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
    130                 135                 140                 


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
145                 150                 155                 160 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
                165                 170                 175     


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
            180                 185                 190         


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
        195                 200                 205             


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
    210                 215                 220                 


Thr Val Ala Pro Thr Glu Cys Ser 
225                 230         


<210>  11
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Heavy chain amino acid sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Asp Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Phe Ile Lys Tyr Val Phe Ala Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  12
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMP-18R5 Light chain amino acid sequence

<400>  12

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Asn Thr Leu Ser Leu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG peptide

<400>  13

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  14
<211>  2364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human SMO nucleotide sequence

<400>  14
atggccgctg cccgcccagc gcgggggccg gagctcccgc tcctggggct gctgctgctg       60

ctgctgctgg gggacccggg ccggggggcg gcctcgagcg ggaacgcgac cgggcctggg      120

cctcggagcg cgggcgggag cgcgaggagg agcgcggcgg tgactggccc tccgccgccg      180

ctgagccact gcggccgggc tgccccctgc gagccgctgc gctacaacgt gtgcctgggc      240

tcggtgctgc cctacggggc cacctccaca ctgctggccg gagactcgga ctcccaggag      300

gaagcgcacg gcaagctcgt gctctggtcg ggcctccgga atgccccccg ctgctgggca      360

gtgatccagc ccctgctgtg tgccgtatac atgcccaagt gtgagaatga ccgggtggag      420

ctgcccagcc gtaccctctg ccaggccacc cgaggcccct gtgccatcgt ggagagggag      480

cggggctggc ctgacttcct gcgctgcact cctgaccgct tccctgaagg ctgcacgaat      540

gaggtgcaga acatcaagtt caacagttca ggccagtgcg aagtgccctt ggttcggaca      600

gacaacccca agagctggta cgaggacgtg gagggctgcg gcatccagtg ccagaacccg      660

ctcttcacag aggctgagca ccaggacatg cacagctaca tcgcggcctt cggggccgtc      720

acgggcctct gcacgctctt caccctggcc acattcgtgg ctgactggcg gaactcgaat      780

cgctaccctg ctgttattct cttctacgtc aatgcgtgct tctttgtggg cagcattggc      840

tggctggccc agttcatgga tggtgcccgc cgagagatcg tctgccgtgc agatggcacc      900

atgaggcttg gggagcccac ctccaatgag actctgtcct gcgtcatcat ctttgtcatc      960

gtgtactacg ccctgatggc tggtgtggtt tggtttgtgg tcctcaccta tgcctggcac     1020

acttccttca aagccctggg caccacctac cagcctctct cgggcaagac ctcctacttc     1080

cacctgctca cctggtcact cccctttgtc ctcactgtgg caatccttgc tgtggcgcag     1140

gtggatgggg actctgtgag tggcatttgt tttgtgggct acaagaacta ccgataccgt     1200

gcgggcttcg tgctggcccc aatcggcctg gtgctcatcg tgggaggcta cttcctcatc     1260

cgaggagtca tgactctgtt ctccatcaag agcaaccacc ccgggctgct gagtgagaag     1320

gctgccagca agatcaacga gaccatgctg cgcctgggca tttttggctt cctggccttt     1380

ggctttgtgc tcattacctt cagctgccac ttctacgact tcttcaacca ggctgagtgg     1440

gagcgcagct tccgggacta tgtgctatgt caggccaatg tgaccatcgg gctgcccacc     1500

aagcagccca tccctgactg tgagatcaag aatcgcccga gccttctggt ggagaagatc     1560

aacctgtttg ccatgtttgg aactggcatc gccatgagca cctgggtctg gaccaaggcc     1620

acgctgctca tctggaggcg tacctggtgc aggttgactg ggcagagtga cgatgagcca     1680

aagcggatca agaagagcaa gatgattgcc aaggccttct ctaagcggca cgagctcctg     1740

cagaacccag gccaggagct gtccttcagc atgcacactg tgtcccacga cgggcccgtg     1800

gcgggcttgg cctttgacct caatgagccc tcagctgatg tctcctctgc ctgggcccag     1860

catgtcacca agatggtggc tcggagagga gccatactgc cccaggatat ttctgtcacc     1920

cctgtggcaa ctccagtgcc cccagaggaa caagccaacc tgtggctggt tgaggcagag     1980

atctccccag agctgcagaa gcgcctgggc cggaagaaga agaggaggaa gaggaagaag     2040

gaggtgtgcc cgctggcgcc gccccctgag cttcaccccc ctgcccctgc ccccagtacc     2100

attcctcgac tgcctcagct gccccggcag aaatgcctgg tggctgcagg tgcctgggga     2160

gctggggact cttgccgaca gggagcgtgg accctggtct ccaacccatt ctgcccagag     2220

cccagtcccc ctcaggatcc atttctgccc agtgcaccgg cccccgtggc atgggctcat     2280

ggccgccgac agggcctggg gcctattcac tcccgcacca acctgatgga cacagaactc     2340

atggatgcag actcggactt ctga                                            2364


<210>  15
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human SMO amino acid sequence

<400>  15

Met Ala Ala Ala Arg Pro Ala Arg Gly Pro Glu Leu Pro Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Asp Pro Gly Arg Gly Ala Ala Ser 
            20                  25                  30          


Ser Gly Asn Ala Thr Gly Pro Gly Pro Arg Ser Ala Gly Gly Ser Ala 
        35                  40                  45              


Arg Arg Ser Ala Ala Val Thr Gly Pro Pro Pro Pro Leu Ser His Cys 
    50                  55                  60                  


Gly Arg Ala Ala Pro Cys Glu Pro Leu Arg Tyr Asn Val Cys Leu Gly 
65                  70                  75                  80  


Ser Val Leu Pro Tyr Gly Ala Thr Ser Thr Leu Leu Ala Gly Asp Ser 
                85                  90                  95      


Asp Ser Gln Glu Glu Ala His Gly Lys Leu Val Leu Trp Ser Gly Leu 
            100                 105                 110         


Arg Asn Ala Pro Arg Cys Trp Ala Val Ile Gln Pro Leu Leu Cys Ala 
        115                 120                 125             


Val Tyr Met Pro Lys Cys Glu Asn Asp Arg Val Glu Leu Pro Ser Arg 
    130                 135                 140                 


Thr Leu Cys Gln Ala Thr Arg Gly Pro Cys Ala Ile Val Glu Arg Glu 
145                 150                 155                 160 


Arg Gly Trp Pro Asp Phe Leu Arg Cys Thr Pro Asp Arg Phe Pro Glu 
                165                 170                 175     


Gly Cys Thr Asn Glu Val Gln Asn Ile Lys Phe Asn Ser Ser Gly Gln 
            180                 185                 190         


Cys Glu Val Pro Leu Val Arg Thr Asp Asn Pro Lys Ser Trp Tyr Glu 
        195                 200                 205             


Asp Val Glu Gly Cys Gly Ile Gln Cys Gln Asn Pro Leu Phe Thr Glu 
    210                 215                 220                 


Ala Glu His Gln Asp Met His Ser Tyr Ile Ala Ala Phe Gly Ala Val 
225                 230                 235                 240 


Thr Gly Leu Cys Thr Leu Phe Thr Leu Ala Thr Phe Val Ala Asp Trp 
                245                 250                 255     


Arg Asn Ser Asn Arg Tyr Pro Ala Val Ile Leu Phe Tyr Val Asn Ala 
            260                 265                 270         


Cys Phe Phe Val Gly Ser Ile Gly Trp Leu Ala Gln Phe Met Asp Gly 
        275                 280                 285             


Ala Arg Arg Glu Ile Val Cys Arg Ala Asp Gly Thr Met Arg Leu Gly 
    290                 295                 300                 


Glu Pro Thr Ser Asn Glu Thr Leu Ser Cys Val Ile Ile Phe Val Ile 
305                 310                 315                 320 


Val Tyr Tyr Ala Leu Met Ala Gly Val Val Trp Phe Val Val Leu Thr 
                325                 330                 335     


Tyr Ala Trp His Thr Ser Phe Lys Ala Leu Gly Thr Thr Tyr Gln Pro 
            340                 345                 350         


Leu Ser Gly Lys Thr Ser Tyr Phe His Leu Leu Thr Trp Ser Leu Pro 
        355                 360                 365             


Phe Val Leu Thr Val Ala Ile Leu Ala Val Ala Gln Val Asp Gly Asp 
    370                 375                 380                 


Ser Val Ser Gly Ile Cys Phe Val Gly Tyr Lys Asn Tyr Arg Tyr Arg 
385                 390                 395                 400 


Ala Gly Phe Val Leu Ala Pro Ile Gly Leu Val Leu Ile Val Gly Gly 
                405                 410                 415     


Tyr Phe Leu Ile Arg Gly Val Met Thr Leu Phe Ser Ile Lys Ser Asn 
            420                 425                 430         


His Pro Gly Leu Leu Ser Glu Lys Ala Ala Ser Lys Ile Asn Glu Thr 
        435                 440                 445             


Met Leu Arg Leu Gly Ile Phe Gly Phe Leu Ala Phe Gly Phe Val Leu 
    450                 455                 460                 


Ile Thr Phe Ser Cys His Phe Tyr Asp Phe Phe Asn Gln Ala Glu Trp 
465                 470                 475                 480 


Glu Arg Ser Phe Arg Asp Tyr Val Leu Cys Gln Ala Asn Val Thr Ile 
                485                 490                 495     


Gly Leu Pro Thr Lys Gln Pro Ile Pro Asp Cys Glu Ile Lys Asn Arg 
            500                 505                 510         


Pro Ser Leu Leu Val Glu Lys Ile Asn Leu Phe Ala Met Phe Gly Thr 
        515                 520                 525             


Gly Ile Ala Met Ser Thr Trp Val Trp Thr Lys Ala Thr Leu Leu Ile 
    530                 535                 540                 


Trp Arg Arg Thr Trp Cys Arg Leu Thr Gly Gln Ser Asp Asp Glu Pro 
545                 550                 555                 560 


Lys Arg Ile Lys Lys Ser Lys Met Ile Ala Lys Ala Phe Ser Lys Arg 
                565                 570                 575     


His Glu Leu Leu Gln Asn Pro Gly Gln Glu Leu Ser Phe Ser Met His 
            580                 585                 590         


Thr Val Ser His Asp Gly Pro Val Ala Gly Leu Ala Phe Asp Leu Asn 
        595                 600                 605             


Glu Pro Ser Ala Asp Val Ser Ser Ala Trp Ala Gln His Val Thr Lys 
    610                 615                 620                 


Met Val Ala Arg Arg Gly Ala Ile Leu Pro Gln Asp Ile Ser Val Thr 
625                 630                 635                 640 


Pro Val Ala Thr Pro Val Pro Pro Glu Glu Gln Ala Asn Leu Trp Leu 
                645                 650                 655     


Val Glu Ala Glu Ile Ser Pro Glu Leu Gln Lys Arg Leu Gly Arg Lys 
            660                 665                 670         


Lys Lys Arg Arg Lys Arg Lys Lys Glu Val Cys Pro Leu Ala Pro Pro 
        675                 680                 685             


Pro Glu Leu His Pro Pro Ala Pro Ala Pro Ser Thr Ile Pro Arg Leu 
    690                 695                 700                 


Pro Gln Leu Pro Arg Gln Lys Cys Leu Val Ala Ala Gly Ala Trp Gly 
705                 710                 715                 720 


Ala Gly Asp Ser Cys Arg Gln Gly Ala Trp Thr Leu Val Ser Asn Pro 
                725                 730                 735     


Phe Cys Pro Glu Pro Ser Pro Pro Gln Asp Pro Phe Leu Pro Ser Ala 
            740                 745                 750         


Pro Ala Pro Val Ala Trp Ala His Gly Arg Arg Gln Gly Leu Gly Pro 
        755                 760                 765             


Ile His Ser Arg Thr Asn Leu Met Asp Thr Glu Leu Met Asp Ala Asp 
    770                 775                 780                 


Ser Asp Phe 
785         


<210>  16
<211>  540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IGF2 nucleotide sequence

<400>  16
atgggaatcc caatggggaa gtcgatgctg gtgcttctca ccttcttggc cttcgcctcg       60

tgctgcattg ctgcttaccg ccccagtgag accctgtgcg gcggggagct ggtggacacc      120

ctccagttcg tctgtgggga ccgcggcttc tacttcagca ggcccgcaag ccgtgtgagc      180

cgtcgcagcc gtggcatcgt tgaggagtgc tgtttccgca gctgtgacct ggccctcctg      240

gagacgtact gtgctacccc cgccaagtcc gagagggacg tgtcgacccc tccgaccgtg      300

cttccggaca acttccccag ataccccgtg ggcaagttct tccaatatga cacctggaag      360

cagtccaccc agcgcctgcg caggggcctg cctgccctcc tgcgtgcccg ccggggtcac      420

gtgctcgcca aggagctcga ggcgttcagg gaggccaaac gtcaccgtcc cctgattgct      480

ctacccaccc aagaccccgc ccacgggggc gcccccccag agatggccag caatcggaag      540


<210>  17
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IGF2 amino acid sequence

<400>  17

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  18
<211>  1236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human TGFb3 nucleotide sequence

<400>  18
atgaagatgc acttgcaaag ggctctggtg gtcctggccc tgctgaactt tgccacggtc       60

agcctctctc tgtccacttg caccaccttg gacttcggcc acatcaagaa gaagagggtg      120

gaagccatta ggggacagat cttgagcaag ctcaggctca ccagcccccc tgagccaacg      180

gtgatgaccc acgtccccta tcaggtcctg gccctttaca acagcacccg ggagctgctg      240

gaggagatgc atggggagag ggaggaaggc tgcacccagg aaaacaccga gtcggaatac      300

tatgccaaag aaatccataa attcgacatg atccaggggc tggcggagca caacgaactg      360

gctgtctgcc ctaaaggaat tacctccaag gttttccgct tcaatgtgtc ctcagtggag      420

aaaaatagaa ccaacctatt ccgagcagaa ttccgggtct tgcgggtgcc caaccccagc      480

tctaagcgga atgagcagag gatcgagctc ttccagatcc ttcggccaga tgagcacatt      540

gccaaacagc gctatatcgg tggcaagaat ctgcccacac ggggcactgc cgagtggctg      600

tcctttgatg tcactgacac tgtgcgtgag tggctgttga gaagagagtc caacttaggt      660

ctagaaatca gcattcactg tccatgtcac acctttcagc ccaatggaga tatcctggaa      720

aacattcacg aggtgatgga aatcaaattc aaaggcgtgg acaatgagga tgaccatggc      780

cgtggagatc tggggcgcct caagaagcag aaggatcacc acaaccctca tctaatcctc      840

atgatgattc ccccacaccg gctcgacaac ccgggccagg ggggtcagag gaagaagcgg      900

gctttggaca ccaattactg cttccgcaac ttggaggaga actgctgtgt gcgccccctc      960

tacattgact tccgacagga tctgggctgg aagtgggtcc atgaacctaa gggctactat     1020

gccaacttct gctcaggccc ttgcccatac ctccgcagtg cagacacaac ccacagcacg     1080

gtgctgggac tgtacaacac tctgaaccct gaagcatctg cctcgccttg ctgcgtgccc     1140

caggacctgg agcccctgac catcctgtac tatgttggga ggacccccaa agtggagcag     1200

ctctccaaca tggtggtgaa gtcttgtaaa tgtagc                               1236


<210>  19
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TGFb3 amino acid sequence

<400>  19

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


