                         SEQUENCE LISTING

<110>  Firmenich SA
 
<120>  CELL LINES FOR SCREENING ODORANT AND AROMA RECEPTORS

<130>  81455-95501

<150>  62/173,762
<151>  2015-06-10

<150>  62/221,580
<151>  2015-09-21

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Guide RNA target sequence

<400>  1
ctgcaatctc agttcagggc c                                                 21


<210>  2
<211>  3628
<212>  DNA
<213>  artificial

<220>
<223>  Donor DNA for homology directed repair

<400>  2
ggggttttat ggaagagtct tacttctctt ttctttcatc tatattttgt attttttcta       60

gaataaaccc atatgatttt ttaaaaggaa aaataattta ttaaaaatag cagcagaggc      120

atgtatagta aaggctgttt tgcctgtggg tggtgctcct cttctgcgct tctataatca      180

gcttggaaat aatcttgtct gctcctgcct ggctgatgca atgctcctac ctttgtgcac      240

aggtggctgt tcttgcacaa ggccattgca gcatggatcc tattgcacag ttattcagta      300

cacagtcagc tacaagcact gacatagagc ttggcacatg tctgcaaacc ctacccacat      360

gctcggatat gtttgaaatg aatgaattaa tgaaccggtc tggggtcaac agcttgaatt      420

tgtatacagg ctccgccatt tataggctag gtgagtccta ggctcctgat ctgtactgca      480

gcaatagtaa tcataactta agagacctcc aattgtgttt tgaaaatggc aaagtgctgg      540

tcacaagatg gctggggaag ccgagagaga gtttattatt attgctccat ctactaacaa      600

atttacatct ccccatccct catttctcct tggctgccta aggcatcatg gttaccgtag      660

cagccagatg ctgatgatgc ctccagggga cggcaaggtg aaactgagcc agttcccagt      720

cctcacctcc ccatactctt tccaggccag ggtgagatgg tctgaagctc agtctctggt      780

caggtccccc actctgtctt ggatcattta gacccgcggc cgcggcgcgc ctcggaattc      840

gattgaagtt cctattccga agttcctatt ctctagaaag tataggaact tcggtgtgga      900

aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca      960

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat     1020

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc     1080

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag     1140

cttgcatgcc tgcaggtcgg ccgccacgac cggtgccgcc accatcccct gacccacgcc     1200

cctgacccct cacaaggaga cgaccttcca tgaccgagta caagcccacg gtgcgcctcg     1260

ccacccgcga cgacgtcccc cgggccgtac gcaccctcgc cgccgcgttc gccgactacc     1320

ccgccacgcg ccacaccgtc gacccggacc gccacatcga gcgggtcacc gagctgcaag     1380

aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt gtgggtcgcg gacgacggcg     1440

ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc gggggcggtg ttcgccgaga     1500

tcggcccgcg catggccgag ttgagcggtt cccggctggc cgcgcagcaa cagatggaag     1560

gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt cctggccacc gtcggcgtct     1620

cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt gctccccgga gtggaggcgg     1680

ccgagcgcgc cggggtgccc gccttcctgg agacctccgc gccccgcaac ctccccttct     1740

acgagcggct cggcttcacc gtcaccgccg acgtcgaggt gcccgaagga ccgcgcacct     1800

ggtgcatgac ccgcaagccc ggtgcctgac gcccgcccca cgacccgcag cgcccgaccg     1860

aaaggagcgc acgaccccat ggctccgacc gaagccaccc ggggcggccc cgccgacccc     1920

gcacccgccc ccgaggccca ccgactctag aggatcataa tcagccatac cacatttgta     1980

gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg     2040

aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat     2100

agcatcacaa atttcacaaa taaagcattt ttttcactgc gaagttccta ttccgaagtt     2160

cctattctct agaaagtata ggaacttcaa tcactagtga attcacgcgt tgacattgat     2220

tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg     2280

agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc     2340

gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt     2400

gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc     2460

atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg     2520

cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg     2580

ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact     2640

cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa     2700

atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta     2760

ggcgtgtacg gtgggaggtc tatataagca gagctcgttt agtgaaccgt gtttaaacct     2820

cttcagagac tccctcctcc ccaagctctg tcttctggca acctgcctgg ttgccgtgga     2880

aacaggttcc actgcggaca aaggagggag ctgggtcctg cttcctcctg gtcttgtcga     2940

tgaggatttt tagaccgtgg agactgcgct gccctgccct gcacctaccc tcactctccg     3000

tgttctcact aaggtggaaa ttgccttccc tcactactga cgagaccatg tgtaaaagcg     3060

tgaccacaga tgagtggaag aaagtcttct atgagaagat ggaggaggca aagccggctg     3120

acagctggga cctcatcata gaccccaacc tcaagcacaa tgtgctgagc cctggttgga     3180

agcagtacct ggaattgcat gcttcaggca ggtgagtagc ccaggaaagt ggatccctgc     3240

aggccgcctc taggtcccta gctctggggc accttccaag gagaggaaga ttacgtagaa     3300

cccaagtgtt tagcttcaat ctcactatta ggctggcgta gactggaagt cagagaaaga     3360

gtccctaact gggaactacg acacttgagt tggatttcag ctcttctact gatcacctgt     3420

gttactcttc ctctctgagt cacaattttt ccgtctggaa aataaagaca tagaatatac     3480

gtatgagtcc tacacactga cattttacat attttctatt ttaacagtct cttaaaaagt     3540

agtttaaaac cagagaagaa gggtttgagg cccactgggg gtcgagacgt ccgtgctctg     3600

gtcctgggac cggtttaaat ctatttaa                                        3628


<210>  3
<211>  928
<212>  DNA
<213>  mouse

<400>  3
atgaaaaccc tcagcagccc cagcaactcc agcaccatca ctggcttcat cctcttgggc       60

ttcgcctacc ccagggaggg gcaaattctc ctctttgtga tcttcttcat tgtttacata      120

ctcattctta tgggcaacgc ttccatcatc tgtgctgtgt actgtgatca gagactccac      180

acccccatgt accttctgct ggccaacttc tccttcatgg agattggata tgtcacctcc      240

acagtcccca acatgttggc caacttcctt tcagacacca aggtcatctc tttctctgga      300

tgcttcctgc agttctattt cttcttctcc tttggttcta cagaatgctt tttcctggca      360

gtcatggcat ttgatcgata ccttgccatc tgtaggccac tacattatcc ttctctcatg      420

actgggcgcc tccgaaacac ccttgtgacc agttgctggg tgcttggttt cctctggttc      480

cctgtaccca tcatcatcat ctcccagatg tccttctgtg ggtccagaat tatagaccac      540

ttcctgtgtg acccaggccc tcttttggcc cttgcctgtt ccagagtccc attgatagag      600

gttttctggt ccattataat gtctatgctc ctggttattc ctttcctctt catcatggga      660

acttacatat tggtcctaag agctgtgttt agacttcctt caagagaagg acaaaaaaag      720

gctttctcca cttgcgggtc tcatctcaca gtagtttcac tcttttattg ctcagtgatg      780

ataatgtatc tgagcccaac atctgagcat gaggccggaa tgcagaagct tgtaactcta      840

ttttattctg tgggtacacc actgcttaat cctatgatat acagtctgag gaacaaagat      900

atgaaaaatg ccctacagaa gattttga                                         928


<210>  4
<211>  311
<212>  PRT
<213>  mouse

<400>  4

Met Lys Thr Leu Ser Ser Pro Ser Asn Ser Ser Thr Ile Thr Gly Phe 
1               5                   10                  15      


Ile Leu Leu Gly Phe Ala Tyr Pro Arg Glu Gly Gln Ile Leu Leu Phe 
            20                  25                  30          


Val Ile Phe Phe Ile Val Tyr Ile Leu Ile Leu Met Gly Asn Ala Ser 
        35                  40                  45              


Ile Ile Cys Ala Val Tyr Cys Asp Gln Arg Leu His Thr Pro Met Tyr 
    50                  55                  60                  


Leu Leu Leu Ala Asn Phe Ser Phe Met Glu Ile Gly Tyr Val Thr Ser 
65                  70                  75                  80  


Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 
                85                  90                  95      


Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Phe Gly 
            100                 105                 110         


Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Cys Arg Pro Leu His Tyr Pro Ser Leu Met Thr Gly Arg Leu 
    130                 135                 140                 


Arg Asn Thr Leu Val Thr Ser Cys Trp Val Leu Gly Phe Leu Trp Phe 
145                 150                 155                 160 


Pro Val Pro Ile Ile Ile Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 
                165                 170                 175     


Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Ala Leu Ala 
            180                 185                 190         


Cys Ser Arg Val Pro Leu Ile Glu Val Phe Trp Ser Ile Ile Met Ser 
        195                 200                 205             


Met Leu Leu Val Ile Pro Phe Leu Phe Ile Met Gly Thr Tyr Ile Leu 
    210                 215                 220                 


Val Leu Arg Ala Val Phe Arg Leu Pro Ser Arg Glu Gly Gln Lys Lys 
225                 230                 235                 240 


Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr 
                245                 250                 255     


Cys Ser Val Met Ile Met Tyr Leu Ser Pro Thr Ser Glu His Glu Ala 
            260                 265                 270         


Gly Met Gln Lys Leu Val Thr Leu Phe Tyr Ser Val Gly Thr Pro Leu 
        275                 280                 285             


Leu Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asn Ala 
    290                 295                 300                 


Leu Gln Lys Ile Leu Arg Thr 
305                 310     


<210>  5
<211>  936
<212>  DNA
<213>  mouse

<400>  5
atgaaaaccc tcagcagccc cagcaactcc agcaccatca ctggcttcat cctcttgggc       60

ttcccctgcc ccagggaggg gcaaatcctc ctctttgtga ccttcttcat tgtttacata      120

ctcattctta tgggcaatgc ttccatcatc tgtgctgtgt actgtgatca gagcctccac      180

acccccatgt acttcctgct ggccaacttc tccttcctgg agatctggta tgtcacctcc      240

acagtcccca acatgttggc caacttcctt tcagacacca aggtcatctc tttctctgga      300

tgcttcctgc agttctattt cttcttctcc tttggttcta cagaatgctt tttcctggca      360

gtcatggcat ttgatcgata ccttgccatc tgtaggccac tacattatcc ttctctcatg      420

actgggcacc tctgcaacat ccttgtgatc agttgctggg tgcttggttt cctctggttc      480

cctgtaccca tcatcatcat ctcccagatg tccttctgtg ggtccagaat tatagaccac      540

ttcctgtgtg acccaggccc tcttttggcc cttgcctgtt ccagagcccc attgatggag      600

gttttctgga caattataat gtctatgctc ctggttattc ctttcctctt catcatggga      660

acttacatat tggtcctaag agctgtgttt agacttcctt caagagatgg acaaaaaaag      720

gccttctcca cttgcgggtc tcatctcaca gtagtttcac tcttttattg ctcagtgatg      780

aaaatgtatt tgagcccaac atctgagcat gaagctggaa tgcagaagct tgtaactcta      840

ttttattctg tgggtactcc actacttaat cctgtgatat acagtctgag gaacaaagat      900

atgaaaaatg ccctgcagaa gattttaaga acataa                                936


<210>  6
<211>  311
<212>  PRT
<213>  mouse

<400>  6

Met Lys Thr Leu Ser Ser Pro Ser Asn Ser Ser Thr Ile Thr Gly Phe 
1               5                   10                  15      


Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu Leu Phe 
            20                  25                  30          


Val Thr Phe Phe Ile Val Tyr Ile Leu Ile Leu Met Gly Asn Ala Ser 
        35                  40                  45              


Ile Ile Cys Ala Val Tyr Cys Asp Gln Ser Leu His Thr Pro Met Tyr 
    50                  55                  60                  


Phe Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 
65                  70                  75                  80  


Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 
                85                  90                  95      


Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Phe Gly 
            100                 105                 110         


Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Cys Arg Pro Leu His Tyr Pro Ser Leu Met Thr Gly His Leu 
    130                 135                 140                 


Cys Asn Ile Leu Val Ile Ser Cys Trp Val Leu Gly Phe Leu Trp Phe 
145                 150                 155                 160 


Pro Val Pro Ile Ile Ile Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 
                165                 170                 175     


Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Ala Leu Ala 
            180                 185                 190         


Cys Ser Arg Ala Pro Leu Met Glu Val Phe Trp Thr Ile Ile Met Ser 
        195                 200                 205             


Met Leu Leu Val Ile Pro Phe Leu Phe Ile Met Gly Thr Tyr Ile Leu 
    210                 215                 220                 


Val Leu Arg Ala Val Phe Arg Leu Pro Ser Arg Asp Gly Gln Lys Lys 
225                 230                 235                 240 


Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr 
                245                 250                 255     


Cys Ser Val Met Lys Met Tyr Leu Ser Pro Thr Ser Glu His Glu Ala 
            260                 265                 270         


Gly Met Gln Lys Leu Val Thr Leu Phe Tyr Ser Val Gly Thr Pro Leu 
        275                 280                 285             


Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asn Ala 
    290                 295                 300                 


Leu Gln Lys Ile Leu Arg Thr 
305                 310     


<210>  7
<211>  942
<212>  DNA
<213>  mouse

<400>  7
atgggaatcc tttccacagg aaatcaaact gtcactgagt ttgtacttct tggtttccat       60

gaagtccctg ggctgcacct cctgtttttt tctgtgttca ccatcctcta tgcctccatc      120

atcacaggga acatgctcat tgcagtggtg gtggtgagct cccagaggct tcacacaccc      180

atgtatttct ttctggtgaa tctgtccttc atagagattg tctatacctc cacagtggtg      240

cccaaaatgc tggaaggctt cttacaggag gccaccatat ctgtggctgg ctgcttgctc      300

cagttctttg tttttggctc tctggccaca gatgagtgtt ttctgctggc tgtgatggca      360

tatgatcgat atctcgcaat ttgtcaccct ctacgatacc cacacctcat ggggcctcaa      420

tggtgcctgg ggttggtgct cacagtctgg ctgtctggct tcatggtaga tggactagtt      480

gttgctctga tggcccagtt gagattctgt ggccccaact tagttgatca cttttactgt      540

gatttttcac ctttgatggt cctggcttgc tcagataccc aagtggccca ggtgactaca      600

tttgttctct ctgtggtctt cctgactgtc ccctttgggc tggttctgat ctcctatgct      660

cagattgtag tgactgtgct gagagttcct tctgggacca gaagaaccaa ggccttctcc      720

acatgctcct ctcacctggc tgtggtgtcc acgttctatg gaacactcat ggtattgtac      780

attgtgccct ctgctgttca ttctcagctc ctctccaagg tcattgccct gctctacaca      840

gtggtcactc ccatcttcaa ccctgtcatc tacaccttga ggaaccagga ggtgcagcag      900

gcactaagaa ggcttctcta ctgcaaacca actgaaatgt ga                         942


<210>  8
<211>  313
<212>  PRT
<213>  mouse

<400>  8

Met Gly Ile Leu Ser Thr Gly Asn Gln Thr Val Thr Glu Phe Val Leu 
1               5                   10                  15      


Leu Gly Phe His Glu Val Pro Gly Leu His Leu Leu Phe Phe Ser Val 
            20                  25                  30          


Phe Thr Ile Leu Tyr Ala Ser Ile Ile Thr Gly Asn Met Leu Ile Ala 
        35                  40                  45              


Val Val Val Val Ser Ser Gln Arg Leu His Thr Pro Met Tyr Phe Phe 
    50                  55                  60                  


Leu Val Asn Leu Ser Phe Ile Glu Ile Val Tyr Thr Ser Thr Val Val 
65                  70                  75                  80  


Pro Lys Met Leu Glu Gly Phe Leu Gln Glu Ala Thr Ile Ser Val Ala 
                85                  90                  95      


Gly Cys Leu Leu Gln Phe Phe Val Phe Gly Ser Leu Ala Thr Asp Glu 
            100                 105                 110         


Cys Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys 
        115                 120                 125             


His Pro Leu Arg Tyr Pro His Leu Met Gly Pro Gln Trp Cys Leu Gly 
    130                 135                 140                 


Leu Val Leu Thr Val Trp Leu Ser Gly Phe Met Val Asp Gly Leu Val 
145                 150                 155                 160 


Val Ala Leu Met Ala Gln Leu Arg Phe Cys Gly Pro Asn Leu Val Asp 
                165                 170                 175     


His Phe Tyr Cys Asp Phe Ser Pro Leu Met Val Leu Ala Cys Ser Asp 
            180                 185                 190         


Thr Gln Val Ala Gln Val Thr Thr Phe Val Leu Ser Val Val Phe Leu 
        195                 200                 205             


Thr Val Pro Phe Gly Leu Val Leu Ile Ser Tyr Ala Gln Ile Val Val 
    210                 215                 220                 


Thr Val Leu Arg Val Pro Ser Gly Thr Arg Arg Thr Lys Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ser His Leu Ala Val Val Ser Thr Phe Tyr Gly Thr Leu 
                245                 250                 255     


Met Val Leu Tyr Ile Val Pro Ser Ala Val His Ser Gln Leu Leu Ser 
            260                 265                 270         


Lys Val Ile Ala Leu Leu Tyr Thr Val Val Thr Pro Ile Phe Asn Pro 
        275                 280                 285             


Val Ile Tyr Thr Leu Arg Asn Gln Glu Val Gln Gln Ala Leu Arg Arg 
    290                 295                 300                 


Leu Leu Tyr Cys Lys Pro Thr Glu Met 
305                 310             


<210>  9
<211>  948
<212>  DNA
<213>  human

<400>  9
atggaaattg tctccacagg aaacgaaact attactgaat ttgtcctcct tggcttctat       60

gacatccctg aactgcattt cttgtttttt attgtattca ctgctgtcta tgtcttcatc      120

atcataggga atatgctgat tattgtagca gtggttagct cccagaggct ccacaaaccc      180

atgtatattt tcttggcgaa tctgtccttc ctggatattc tctacacctc cgcagtgatg      240

ccaaaaatgc tggagggctt cctgcaagaa gcaactatct ctgtggctgg ttgcttgctc      300

cagttcttta tcttcggctc tctagccaca gctgaatgct tactgctggc tgtcatggca      360

tatgaccgct acctggcaat ttgctaccca ctccactacc cactcctgat ggggcccaga      420

cggtacatgg ggctggtggt cacaacctgg ctctctggat ttgtggtaga tggactggtt      480

gtggccctgg tggcccagct gaggttctgt ggccccaacc acattgacca gttttactgt      540

gactttatgc ttttcgtggg cctggcttgc tcggatccca gagtggctca ggtgacaact      600

ctcattctgt ctgtgttctg cctcactatt ccttttggac tgattctgac atcttatgcc      660

agaattgtgg tggcagtgct gagagttcct gctggggcaa gcaggagaag ggctttctcc      720

acatgctcct cccacctagc tgtagtgacc acattctatg gaacgctcat gatcttttat      780

gttgcaccct ctgctgtcca ttcccagctc ctctccaagg tcttctccct gctctacact      840

gtggtcaccc ctctcttcaa tcctgtgatc tataccatga ggaacaagga ggtgcatcag      900

gcacttcgga agattctctg tatcaaacaa actgaaacac ttgattga                   948


<210>  10
<211>  315
<212>  PRT
<213>  human

<400>  10

Met Glu Ile Val Ser Thr Gly Asn Glu Thr Ile Thr Glu Phe Val Leu 
1               5                   10                  15      


Leu Gly Phe Tyr Asp Ile Pro Glu Leu His Phe Leu Phe Phe Ile Val 
            20                  25                  30          


Phe Thr Ala Val Tyr Val Phe Ile Ile Ile Gly Asn Met Leu Ile Ile 
        35                  40                  45              


Val Ala Val Val Ser Ser Gln Arg Leu His Lys Pro Met Tyr Ile Phe 
    50                  55                  60                  


Leu Ala Asn Leu Ser Phe Leu Asp Ile Leu Tyr Thr Ser Ala Val Met 
65                  70                  75                  80  


Pro Lys Met Leu Glu Gly Phe Leu Gln Glu Ala Thr Ile Ser Val Ala 
                85                  90                  95      


Gly Cys Leu Leu Gln Phe Phe Ile Phe Gly Ser Leu Ala Thr Ala Glu 
            100                 105                 110         


Cys Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys 
        115                 120                 125             


Tyr Pro Leu His Tyr Pro Leu Leu Met Gly Pro Arg Arg Tyr Met Gly 
    130                 135                 140                 


Leu Val Val Thr Thr Trp Leu Ser Gly Phe Val Val Asp Gly Leu Val 
145                 150                 155                 160 


Val Ala Leu Val Ala Gln Leu Arg Phe Cys Gly Pro Asn His Ile Asp 
                165                 170                 175     


Gln Phe Tyr Cys Asp Phe Met Leu Phe Val Gly Leu Ala Cys Ser Asp 
            180                 185                 190         


Pro Arg Val Ala Gln Val Thr Thr Leu Ile Leu Ser Val Phe Cys Leu 
        195                 200                 205             


Thr Ile Pro Phe Gly Leu Ile Leu Thr Ser Tyr Ala Arg Ile Val Val 
    210                 215                 220                 


Ala Val Leu Arg Val Pro Ala Gly Ala Ser Arg Arg Arg Ala Phe Ser 
225                 230                 235                 240 


Thr Cys Ser Ser His Leu Ala Val Val Thr Thr Phe Tyr Gly Thr Leu 
                245                 250                 255     


Met Ile Phe Tyr Val Ala Pro Ser Ala Val His Ser Gln Leu Leu Ser 
            260                 265                 270         


Lys Val Phe Ser Leu Leu Tyr Thr Val Val Thr Pro Leu Phe Asn Pro 
        275                 280                 285             


Val Ile Tyr Thr Met Arg Asn Lys Glu Val His Gln Ala Leu Arg Lys 
    290                 295                 300                 


Ile Leu Cys Ile Lys Gln Thr Glu Thr Leu Asp 
305                 310                 315 


<210>  11
<211>  936
<212>  DNA
<213>  mouse

<400>  11
atgaaaacct tcagcagccc catcaactcc agcaccacca ctggcttcat tctcttgggc       60

ttcccctgcc ccagggaggg gcaaatcctc ctctttgtgc tcttctccat tgtctacctg      120

cttaccctca tgggcaacac ttgcatcatc tttgcagtat gctgggatca gagactccac      180

acacccatgt acctactgct ggccaacttc tccttcctgg agatctggta tgttacctcc      240

acagtcccca acatgttggc caatttcctc tctgacacca aggtcatctc tttctctgga      300

tgcttcctgc agttctattt cttcttctcc ttgggttcta cagaatgcct tttcctggca      360

gtcatggcat ttgatcgata ccttgccatc tgtaggccac tacattatcc tgctctcatg      420

actgggagcc tctgcaacat ccttgtgatc agttgctggg tgcttggttt cctctggttc      480

cctgttccca tcatcatcat ctcccagatg tccttctgtg ggtccagaat tatagaccac      540

ttcctgtgtg acccaggccc tctattggcc ctcacctgtt ccagagcccc attaatggag      600

gttttctgga caattataac atctcttatc ctgttcgttc ctttcctctt catcatggga      660

tcttatacat tggtcctgag agctgtgttc agagttcctt caagagatgg acaaaaaaag      720

gctttctcca cttgcggatc tcatctcaca gtagttttac tcttttatgg ctcagtgatg      780

ataatgtatc taagcccgac ctctgagcat gaagctggaa tgcagaagct tgtgactcta      840

ttttattctg tggttactcc actcattaat cctgtgatat acagtctgag gaacaaggat      900

atgaaacatg ccctgcagaa gattttaaga acataa                                936


<210>  12
<211>  311
<212>  PRT
<213>  mouse

<400>  12

Met Lys Thr Phe Ser Ser Pro Ile Asn Ser Ser Thr Thr Thr Gly Phe 
1               5                   10                  15      


Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu Leu Phe 
            20                  25                  30          


Val Leu Phe Ser Ile Val Tyr Leu Leu Thr Leu Met Gly Asn Thr Cys 
        35                  40                  45              


Ile Ile Phe Ala Val Cys Trp Asp Gln Arg Leu His Thr Pro Met Tyr 
    50                  55                  60                  


Leu Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 
65                  70                  75                  80  


Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 
                85                  90                  95      


Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 
            100                 105                 110         


Ser Thr Glu Cys Leu Phe Leu Ala Val Met Ala Phe Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Cys Arg Pro Leu His Tyr Pro Ala Leu Met Thr Gly Ser Leu 
    130                 135                 140                 


Cys Asn Ile Leu Val Ile Ser Cys Trp Val Leu Gly Phe Leu Trp Phe 
145                 150                 155                 160 


Pro Val Pro Ile Ile Ile Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 
                165                 170                 175     


Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Ala Leu Thr 
            180                 185                 190         


Cys Ser Arg Ala Pro Leu Met Glu Val Phe Trp Thr Ile Ile Thr Ser 
        195                 200                 205             


Leu Ile Leu Phe Val Pro Phe Leu Phe Ile Met Gly Ser Tyr Thr Leu 
    210                 215                 220                 


Val Leu Arg Ala Val Phe Arg Val Pro Ser Arg Asp Gly Gln Lys Lys 
225                 230                 235                 240 


Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Leu Leu Phe Tyr 
                245                 250                 255     


Gly Ser Val Met Ile Met Tyr Leu Ser Pro Thr Ser Glu His Glu Ala 
            260                 265                 270         


Gly Met Gln Lys Leu Val Thr Leu Phe Tyr Ser Val Val Thr Pro Leu 
        275                 280                 285             


Ile Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys His Ala 
    290                 295                 300                 


Leu Gln Lys Ile Leu Arg Thr 
305                 310     


<210>  13
<211>  930
<212>  DNA
<213>  human

<400>  13
atgagggaaa ataaccagtc ctctacactg gaattcatcc tcctgggagt tactggtcag       60

caggaacagg aagatttctt ctacatcctc ttcttgttca tttaccccat cacattgatt      120

ggaaacctgc tcatcgtcct agccatttgc tctgatgttc gccttcacaa ccccatgtat      180

tttctccttg ccaacctctc cttggttgac atcttcttct catcggtaac catccctaag      240

atgctggcca accatctctt gggcagcaaa tccatctctt ttgggggatg cctaacgcag      300

atgtatttca tgatagcctt gggtaacaca gacagctata ttttggctgc aatggcatat      360

gatcgagctg tggccatcag ccgcccactt cactacacaa caattatgag tccacggtct      420

tgtatctggc ttattgctgg gtcttgggtg attggaaatg ccaatgccct cccccacact      480

ctgctcacag ctagtctgtc cttctgtggc aaccaggaag tggccaactt ctactgtgac      540

attaccccct tgctgaagtt atcctgttct gacatccact ttcatgtgaa gatgatgtac      600

ctaggggttg gcattttctc tgtgccatta ctatgcatca ttgtctccta tattcgagtc      660

ttctccacag tcttccaggt tccttccacc aagggcgtgc tcaaggcctt ctccacctgt      720

ggttcccacc tcacggttgt ctctttgtat tatggtacag tcatgggcac gtatttccgc      780

cctttgacca attatagcct aaaagacgca gtgatcactg taatgtacac ggcagtgacc      840

ccaatgttaa atcctttcat ctacagtctg agaaatcggg acatgaaggc tgccctgcgg      900

aaactcttca acaagagaat ctcctcgtga                                       930


<210>  14
<211>  309
<212>  PRT
<213>  human

<400>  14

Met Arg Glu Asn Asn Gln Ser Ser Thr Leu Glu Phe Ile Leu Leu Gly 
1               5                   10                  15      


Val Thr Gly Gln Gln Glu Gln Glu Asp Phe Phe Tyr Ile Leu Phe Leu 
            20                  25                  30          


Phe Ile Tyr Pro Ile Thr Leu Ile Gly Asn Leu Leu Ile Val Leu Ala 
        35                  40                  45              


Ile Cys Ser Asp Val Arg Leu His Asn Pro Met Tyr Phe Leu Leu Ala 
    50                  55                  60                  


Asn Leu Ser Leu Val Asp Ile Phe Phe Ser Ser Val Thr Ile Pro Lys 
65                  70                  75                  80  


Met Leu Ala Asn His Leu Leu Gly Ser Lys Ser Ile Ser Phe Gly Gly 
                85                  90                  95      


Cys Leu Thr Gln Met Tyr Phe Met Ile Ala Leu Gly Asn Thr Asp Ser 
            100                 105                 110         


Tyr Ile Leu Ala Ala Met Ala Tyr Asp Arg Ala Val Ala Ile Ser Arg 
        115                 120                 125             


Pro Leu His Tyr Thr Thr Ile Met Ser Pro Arg Ser Cys Ile Trp Leu 
    130                 135                 140                 


Ile Ala Gly Ser Trp Val Ile Gly Asn Ala Asn Ala Leu Pro His Thr 
145                 150                 155                 160 


Leu Leu Thr Ala Ser Leu Ser Phe Cys Gly Asn Gln Glu Val Ala Asn 
                165                 170                 175     


Phe Tyr Cys Asp Ile Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Ile 
            180                 185                 190         


His Phe His Val Lys Met Met Tyr Leu Gly Val Gly Ile Phe Ser Val 
        195                 200                 205             


Pro Leu Leu Cys Ile Ile Val Ser Tyr Ile Arg Val Phe Ser Thr Val 
    210                 215                 220                 


Phe Gln Val Pro Ser Thr Lys Gly Val Leu Lys Ala Phe Ser Thr Cys 
225                 230                 235                 240 


Gly Ser His Leu Thr Val Val Ser Leu Tyr Tyr Gly Thr Val Met Gly 
                245                 250                 255     


Thr Tyr Phe Arg Pro Leu Thr Asn Tyr Ser Leu Lys Asp Ala Val Ile 
            260                 265                 270         


Thr Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 
        275                 280                 285             


Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Arg Lys Leu Phe Asn 
    290                 295                 300                 


Lys Arg Ile Ser Ser 
305                 


<210>  15
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Flag tag

<400>  15
gattacaagg acgacgacga taag                                              24


<210>  16
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Flag tag

<400>  16

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  17
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  Rho tag

<400>  17
atgaacggga ccgagggccc aaacttctac gtgcctttct ccaacaagac gggcgtggtg       60


<210>  18
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Rho tag

<400>  18

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Lys 
1               5                   10                  15      


Thr Gly Val Val 
            20  


<210>  19
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  Lucy tag

<400>  19
atgagacccc agatcctgct gctcctggcc ctgctgaccc taggcctggc t                51


<210>  20
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  Lucy tag

<400>  20

Met Arg Pro Gln Ile Leu Leu Leu Leu Ala Leu Leu Thr Leu Gly Leu 
1               5                   10                  15      


Ala 
    


