                         SEQUENCE LISTING

<110>  Emory University
       Children's Healthcare of Atlanta, Inc.
 
<120>  Compositions and Conjugates Comprising an Interleukin and 
       Polypeptides That Specifically Bind TGF-beta

<130>  15107PCT

<150>  US 62/173,592
<151>  2015-06-10

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135         


<210>  2
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  3
<211>  61
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
1               5                   10                  15      


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    50                  55                  60      


<210>  4
<211>  61
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Cys Pro Pro Pro Val Ser Ile Glu His Ala Asp Ile Arg Val Lys Asn 
1               5                   10                  15      


Tyr Ser Val Asn Ser Arg Glu Arg Tyr Val Cys Asn Ser Gly Phe Lys 
            20                  25                  30          


Arg Lys Ala Gly Thr Ser Thr Leu Ile Glu Cys Val Ile Asn Lys Asn 
        35                  40                  45              


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    50                  55                  60      


<210>  5
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Ser Gly Gly Thr Ser Gly Ser Thr Ser Gly Thr Gly Ser Thr 
1               5                   10                  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Ala Gly Ser Ser Thr Gly Ser Ser Thr Gly Pro Gly Ser Thr Thr 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Gly Gly Ser Gly Gly Ala Pro 
1               5           


<210>  8
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Gly Gly Gly Val Glu Gly Gly Gly 
1               5               


<210>  9
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Gly Thr Lys Val His Met Lys 
1               5           


<210>  10
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Pro Gly Thr Ser Gly Gln Gln Pro Ser Val Gly Gln Gln 
1               5                   10              


<210>  11
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Gly Thr Ser Gly Gln 
1               5   


<210>  12
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
1               5                   10  


<210>  13
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Gly Gly Ser Ser Gly Gly 
1               5       


<210>  14
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Leu Gln 
            


<210>  15
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Asp Asp Asp Asp Lys 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Ile Glu Asp Gly Arg 
1               5   


<210>  17
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Leu Val Pro Arg Gly Ser 
1               5       


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  19
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  20
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Leu Phe Pro Thr Ser 
1               5   


<210>  21
<211>  355
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Thr Gly Gly Ser Ser Gly 
    130                 135                 140                 


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
145                 150                 155                 160 


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
                165                 170                 175     


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
            180                 185                 190         


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
        195                 200                 205             


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
225                 230                 235                 240 


Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                245                 250                 255     


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
            260                 265                 270         


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
        275                 280                 285             


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
    290                 295                 300                 


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
305                 310                 315                 320 


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                325                 330                 335     


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
            340                 345                 350         


Asn Thr Ser 
        355 


<210>  22
<211>  567
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  23
<211>  162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  24
<211>  506
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

His His His His His His His His Glu Asn Leu Tyr Phe Gln Gly Ser 
1               5                   10                  15      


Ile Pro Pro His Val Pro Lys Ser Val Asn Ser Asp Val Met Ala Ser 
            20                  25                  30          


Asp Asn Gly Gly Ala Val Lys Leu Pro Gln Leu Cys Lys Phe Cys Asp 
        35                  40                  45              


Val Arg Leu Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
    50                  55                  60                  


Ser Ile Thr Ala Ile Cys Glu Lys Pro His Glu Val Cys Val Ala Val 
65                  70                  75                  80  


Trp Arg Lys Asn Asp Lys Asn Ile Thr Leu Glu Thr Val Cys His Asp 
                85                  90                  95      


Pro Lys Leu Thr Tyr His Gly Phe Thr Leu Glu Asp Ala Ala Ser Pro 
            100                 105                 110         


Lys Cys Val Met Lys Glu Lys Lys Arg Ala Gly Glu Thr Phe Phe Met 
        115                 120                 125             


Cys Ala Cys Asn Met Glu Glu Cys Asn Asp Tyr Ile Ile Phe Ser Glu 
    130                 135                 140                 


Glu Tyr Thr Thr Ser Ser Pro Asp Ile Pro Pro His Val Pro Lys Ser 
145                 150                 155                 160 


Val Asn Ser Asp Val Met Ala Ser Asp Asn Gly Gly Ala Val Lys Leu 
                165                 170                 175     


Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Leu Ser Thr Cys Asp Asn 
            180                 185                 190         


Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ala Ile Cys Glu Lys 
        195                 200                 205             


Pro His Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Lys Asn Ile 
    210                 215                 220                 


Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Thr Tyr His Gly Phe 
225                 230                 235                 240 


Thr Leu Glu Asp Ala Ala Ser Pro Lys Cys Val Met Lys Glu Lys Lys 
                245                 250                 255     


Arg Ala Gly Glu Thr Phe Phe Met Cys Ala Cys Asn Met Glu Glu Cys 
            260                 265                 270         


Asn Asp Tyr Ile Ile Phe Ser Glu Glu Tyr Thr Thr Ser Ser Pro Asp 
        275                 280                 285             


Gly Thr Gly Gly Ser Ser Gly Gly Thr Thr Cys Pro Pro Pro Val Ser 
    290                 295                 300                 


Ile Glu His Ala Asp Ile Arg Val Lys Asn Tyr Ser Val Asn Ser Arg 
305                 310                 315                 320 


Glu Arg Tyr Val Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
                325                 330                 335     


Thr Leu Ile Glu Cys Val Ile Asn Lys Asn Thr Asn Val Ala His Trp 
            340                 345                 350         


Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ser Leu Ala His Tyr 
        355                 360                 365             


Ser Pro Val Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp Ile Asp Val Arg Tyr Asp 
385                 390                 395                 400 


Leu Glu Lys Ile Glu Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr 
                405                 410                 415     


Leu Tyr Thr Asp Ser Asp Phe His Pro Ser Cys Lys Val Thr Ala Met 
            420                 425                 430         


Asn Cys Phe Leu Leu Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn 
        435                 440                 445             


Met Thr Leu Asn Glu Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser 
    450                 455                 460                 


Thr Leu Ser Ser Asn Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys 
465                 470                 475                 480 


Glu Glu Leu Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile 
                485                 490                 495     


Arg Ile Val Gln Met Phe Ile Asn Thr Ser 
            500                 505     


<210>  25
<211>  531
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Glu Asn Leu Tyr Phe Gln 
            20                  25                  30          


Ser His His His His His His His His Ile Pro Pro His Val Pro Lys 
        35                  40                  45              


Ser Val Asn Ser Asp Val Met Ala Ser Asp Asn Gly Gly Ala Val Lys 
    50                  55                  60                  


Leu Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Leu Ser Thr Cys Asp 
65                  70                  75                  80  


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ala Ile Cys Glu 
                85                  90                  95      


Lys Pro His Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Lys Asn 
            100                 105                 110         


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Thr Tyr His Gly 
        115                 120                 125             


Phe Thr Leu Glu Asp Ala Ala Ser Pro Lys Cys Val Met Lys Glu Lys 
    130                 135                 140                 


Lys Arg Ala Gly Glu Thr Phe Phe Met Cys Ala Cys Asn Met Glu Glu 
145                 150                 155                 160 


Cys Asn Asp Tyr Ile Ile Phe Ser Glu Glu Tyr Thr Thr Ser Ser Pro 
                165                 170                 175     


Asp Ile Pro Pro His Val Pro Lys Ser Val Asn Ser Asp Val Met Ala 
            180                 185                 190         


Ser Asp Asn Gly Gly Ala Val Lys Leu Pro Gln Leu Cys Lys Phe Cys 
        195                 200                 205             


Asp Val Arg Leu Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
    210                 215                 220                 


Cys Ser Ile Thr Ala Ile Cys Glu Lys Pro His Glu Val Cys Val Ala 
225                 230                 235                 240 


Val Trp Arg Lys Asn Asp Lys Asn Ile Thr Leu Glu Thr Val Cys His 
                245                 250                 255     


Asp Pro Lys Leu Thr Tyr His Gly Phe Thr Leu Glu Asp Ala Ala Ser 
            260                 265                 270         


Pro Lys Cys Val Met Lys Glu Lys Lys Arg Ala Gly Glu Thr Phe Phe 
        275                 280                 285             


Met Cys Ala Cys Asn Met Glu Glu Cys Asn Asp Tyr Ile Ile Phe Ser 
    290                 295                 300                 


Glu Glu Tyr Thr Thr Ser Ser Pro Asp Gly Thr Gly Gly Ser Ser Gly 
305                 310                 315                 320 


Gly Thr Thr Cys Pro Pro Pro Val Ser Ile Glu His Ala Asp Ile Arg 
                325                 330                 335     


Val Lys Asn Tyr Ser Val Asn Ser Arg Glu Arg Tyr Val Cys Asn Ser 
            340                 345                 350         


Gly Phe Lys Arg Lys Ala Gly Thr Ser Thr Leu Ile Glu Cys Val Ile 
        355                 360                 365             


Asn Lys Asn Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    370                 375                 380                 


Ile Arg Asp Pro Ser Leu Ala His Tyr Ser Pro Val Pro Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                405                 410                 415     


Gln Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu 
            420                 425                 430         


Ile Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe 
        435                 440                 445             


His Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu 
    450                 455                 460                 


Gln Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val 
465                 470                 475                 480 


Arg Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn 
                485                 490                 495     


Val Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr 
            500                 505                 510         


Phe Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile 
        515                 520                 525             


Asn Thr Ser 
    530     


<210>  26
<211>  508
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

His His His His His His His His Glu Asn Leu Tyr Phe Gln Gly Ser 
1               5                   10                  15      


Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
            20                  25                  30          


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
        35                  40                  45              


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
    50                  55                  60                  


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
65                  70                  75                  80  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
                85                  90                  95      


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
            100                 105                 110         


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
        115                 120                 125             


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
    130                 135                 140                 


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Thr Ile Pro Pro His Val Gln 
145                 150                 155                 160 


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
                165                 170                 175     


Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys 
            180                 185                 190         


Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys 
        195                 200                 205             


Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu 
    210                 215                 220                 


Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His 
225                 230                 235                 240 


Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 
                245                 250                 255     


Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp 
            260                 265                 270         


Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn 
        275                 280                 285             


Pro Asp Gly Thr Gly Gly Ser Ser Gly Ile Thr Cys Pro Pro Pro Met 
    290                 295                 300                 


Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser 
305                 310                 315                 320 


Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr 
                325                 330                 335     


Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His 
            340                 345                 350         


Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His 
        355                 360                 365             


Gln Arg Pro Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile 
385                 390                 395                 400 


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
                405                 410                 415     


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
            420                 425                 430         


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
        435                 440                 445             


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
    450                 455                 460                 


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
465                 470                 475                 480 


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
                485                 490                 495     


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            500                 505             


<210>  27
<211>  492
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp Thr Ile Pro Pro His Val Gln 
    130                 135                 140                 


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
145                 150                 155                 160 


Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys 
                165                 170                 175     


Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys 
            180                 185                 190         


Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu 
        195                 200                 205             


Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His 
    210                 215                 220                 


Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 
225                 230                 235                 240 


Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp 
                245                 250                 255     


Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn 
            260                 265                 270         


Pro Asp Gly Thr Gly Gly Ser Ser Gly Ile Thr Cys Pro Pro Pro Met 
        275                 280                 285             


Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser 
    290                 295                 300                 


Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr 
305                 310                 315                 320 


Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His 
                325                 330                 335     


Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His 
            340                 345                 350         


Gln Arg Pro Ala Pro Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile 
    370                 375                 380                 


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
385                 390                 395                 400 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
                405                 410                 415     


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
            420                 425                 430         


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
        435                 440                 445             


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
    450                 455                 460                 


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
465                 470                 475                 480 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
                485                 490         


<210>  28
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala 
            20                  25      


