                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
      DANA FARBER CANCER INSTITUTE, INC.
 
<120> METHODS FOR TREATMENT OF MELANOMA

<130> 701039-064587-PCT2

<140> PCT/US2016/036161
<141> 2016-06-07

<150> 14/733,498
<151> 2015-06-08

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 766
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210> 2
<211> 396
<212> PRT
<213> Homo sapiens

<400> 2
Lys Leu Pro Trp Arg His Leu Gln Lys Arg Ala Gln Asp Ala Val Ile 
1               5                   10                  15      


Ile Leu Gly Gly Gly Gly Leu Leu Phe Ala Ser Tyr Leu Met Ala Thr 
            20                  25                  30          


Gly Asp Glu Arg Phe Tyr Ala Glu His Leu Met Pro Thr Leu Gln Gly 
        35                  40                  45              


Leu Leu Asp Pro Glu Ser Ala His Arg Leu Ala Val Arg Phe Thr Ser 
    50                  55                  60                  


Leu Gly Leu Leu Pro Arg Ala Arg Phe Gln Asp Ser Asp Met Leu Glu 
65                  70                  75                  80  


Val Arg Val Leu Gly His Lys Phe Arg Asn Pro Val Gly Ile Ala Ala 
                85                  90                  95      


Gly Phe Asp Lys His Gly Glu Ala Val Asp Gly Leu Tyr Lys Met Gly 
            100                 105                 110         


Phe Gly Phe Val Glu Ile Gly Ser Val Thr Pro Lys Pro Gln Glu Gly 
        115                 120                 125             


Asn Pro Arg Pro Arg Val Phe Arg Leu Pro Glu Asp Gln Ala Val Ile 
    130                 135                 140                 


Asn Arg Tyr Gly Phe Asn Ser His Gly Leu Ser Val Val Glu His Arg 
145                 150                 155                 160 


Leu Arg Ala Arg Gln Gln Lys Gln Ala Lys Leu Thr Glu Asp Gly Leu 
                165                 170                 175     


Pro Leu Gly Val Asn Leu Gly Lys Asn Lys Thr Ser Val Asp Ala Ala 
            180                 185                 190         


Glu Asp Tyr Ala Glu Gly Val Arg Val Leu Gly Pro Leu Ala Asp Tyr 
        195                 200                 205             


Leu Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu 
    210                 215                 220                 


Gln Gly Lys Ala Glu Leu Arg Arg Leu Leu Thr Lys Val Leu Gln Glu 
225                 230                 235                 240 


Arg Asp Gly Leu Arg Arg Val His Arg Pro Ala Val Leu Val Lys Ile 
                245                 250                 255     


Ala Pro Asp Leu Thr Ser Gln Asp Lys Glu Asp Ile Ala Ser Val Val 
            260                 265                 270         


Lys Glu Leu Gly Ile Asp Gly Leu Ile Val Thr Asn Thr Thr Val Ser 
        275                 280                 285             


Arg Pro Ala Gly Leu Gln Gly Ala Leu Arg Ser Glu Thr Gly Gly Leu 
    290                 295                 300                 


Ser Gly Lys Pro Leu Arg Asp Leu Ser Thr Gln Thr Ile Arg Glu Met 
305                 310                 315                 320 


Tyr Ala Leu Thr Gln Gly Arg Val Pro Ile Ile Gly Val Gly Gly Val 
                325                 330                 335     


Ser Ser Gly Gln Asp Ala Leu Glu Lys Ile Arg Ala Gly Ala Ser Leu 
            340                 345                 350         


Val Gln Leu Tyr Thr Ala Leu Thr Phe Trp Gly Pro Pro Val Val Gly 
        355                 360                 365             


Lys Val Lys Arg Glu Leu Glu Ala Leu Leu Lys Glu Gln Gly Phe Gly 
    370                 375                 380                 


Gly Val Thr Asp Ala Ile Gly Ala Asp His Arg Arg 
385                 390                 395     


<210> 3
<211> 766
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Glu Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser 
705                 710                 715                 720 


Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg Ala 
                725                 730                 735     


Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys 
            740                 745                 750         


Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val His 
        755                 760                 765     


<210> 4
<211> 2438
<212> DNA
<213> Homo sapiens

<400> 4
gggcttaatg acggaaggag catggcgtgg agacacctga aaaagcgggc ccaggatgct       60

gtgatcatcc tggggggagg aggacttctc ttcgcctcct acctgatggc cacgggagat      120

gagcgtttct atgctgaaca cctgatgccg actctgcagg ggctgctgga cccggagtca      180

gcccacagac tggctgttcg cttcacctcc ctggggctcc ttccacgggc cagatttcaa      240

gactctgaca tgctggaagt gagagttctg ggccataaat tccgaaatcc agtaggaatt      300

gctgcaggat ttgacaagca tggggaagcc gtggacggac tttataagat gggctttggt      360

tttgttgaga taggaagtgt gactccaaaa cctcaggaag gaaaccctag acccagagtc      420

ttccgcctcc ctgaggacca agctgtcatt aacaggtatg gatttaacag tcacgggctt      480

tcagtggtgg aacacaggtt acgggccaga cagcagaagc aggccaagct cacagaagat      540

ggactgcctc tgggggtcaa cttggggaag aacaagacct cagtggacgc cgcggaggac      600

tacgcagaag gggtgcgcgt actgggcccc ctggccgact acctggtggt gaatgtgtcc      660

agccccaaca ctgccgggct gcggagcctt cagggaaagg ccgagctgcg ccgcctgctg      720

accaaggtgc tgcaggagag ggatggcttg cggagagtgc acaggccggc agtcctggtg      780

aagatcgctc ctgacctcac cagccaggat aaggaggaca ttgccagtgt ggtcaaagag      840

ttgggcatcg atgggctgat tgttacgaac accaccgtga gtcgccctgc gggcctccag      900

ggtgccctgc gctctgaaac aggagggctg agtgggaagc ccctccggga tttatcaact      960

caaaccattc gggagatgta tgcactcacc caaggccgag ttcccataat tggggttggt     1020

ggtgtgagca gcgggcagga cgcgctggag aagatccggg caggggcctc cctggtgcag     1080

ctgtacacgg ccctcacctt ctgggggcca cccgttgtgg gcaaagtcaa gcgggaactg     1140

gaggcccttc tgaaagagca gggctttggc ggagtcacag atgccattgg agcagatcat     1200

cggaggtgag gacagcgtct gacgggaagc ctgatctgga accttcccaa ggactcaggc     1260

aagcctttgt ggctggatca tgagaggagg gactccatct tgagccatgt cccccagcca     1320

tggcatggct gcactgtaaa cgccaatcgg ggggtcacca ggatcaaccg caggctttct     1380

tcagtccctt ggtcagacca taaactgcat ttttgattct ttgtggattc aaaccctagg     1440

atccatcagt cttgcaagga cattgaatat taggaggaaa aagtcatgga aaaaataaag     1500

ccatttagaa cctgggtttc aacgctagcc ctttctggtt tgccataggc cctgccaaga     1560

tactgcaggt ccatccaggc ctctgctatc tgcatctgca gtgggcttcc caggaacttg     1620

actgtctttc atttgatctt tatttttgtt tatttaatat tttaaacttt attttaaaaa     1680

tatttcaaac ataagggcgg ggtgtggtgg ctcatgcctg taatcccagc actttgggag     1740

gccgaggcgg gcggatcacc tgaggccagg agttggagac cagccaggcc accatggtga     1800

aaccctgtct ctaccaaaaa tacaaaaaat tagccagata ttgtggcagg cacttttaat     1860

cccagctact cgggaggctg aggcaggaga attgcttgaa cctgggaggc ggaggttgca     1920

gtgagccaag attgcaccag tgcactccag cttgggcgac agatcaagac tctgtcacac     1980

acaaaacaaa caaacaaatt ttcccgtttc tctctgtccc tttctctata acatggataa     2040

aatattcacg tcttatgtat ttattattgc tgagtcattg gtgccttatt cttcagtgtt     2100

tcagtctgta tctcctaagc atcctgatgt tagttttttg actataaaat tgacctgcat     2160

tctttactag caattcaaac ggtacagcac tcttgaagtg taaacattcc tgttcctcct     2220

caccccactc tgcagacatg cctttctgtc tgtcctccca gacttttccc ctgcataaag     2280

atgttcattt tgtacataca ctcagacata catgtggctg tattttttgt ataccgattt     2340

ctggatggaa tgcacactgt tatctgttta gttactttat gttttcatac aaatgacatc     2400

atcccacaaa tagaattctg ccatttaaaa aaaaaaaa                             2438


<210> 5
<211> 2949
<212> DNA
<213> Homo sapiens

<400> 5
cgcctccctt ccccctcccc gcccgacagc ggccgctcgg gccccggctc tcggttataa       60

gatggcggcg ctgagcggtg gcggtggtgg cggcgcggag ccgggccagg ctctgttcaa      120

cggggacatg gagcccgagg ccggcgccgg cgccggcgcc gcggcctctt cggctgcgga      180

ccctgccatt ccggaggagg tgtggaatat caaacaaatg attaagttga cacaggaaca      240

tatagaggcc ctattggaca aatttggtgg ggagcataat ccaccatcaa tatatctgga      300

ggcctatgaa gaatacacca gcaagctaga tgcactccaa caaagagaac aacagttatt      360

ggaatctctg gggaacggaa ctgatttttc tgtttctagc tctgcatcaa tggataccgt      420

tacatcttct tcctcttcta gcctttcagt gctaccttca tctctttcag tttttcaaaa      480

tcccacagat gtggcacgga gcaaccccaa gtcaccacaa aaacctatcg ttagagtctt      540

cctgcccaac aaacagagga cagtggtacc tgcaaggtgt ggagttacag tccgagacag      600

tctaaagaaa gcactgatga tgagaggtct aatcccagag tgctgtgctg tttacagaat      660

tcaggatgga gagaagaaac caattggttg ggacactgat atttcctggc ttactggaga      720

agaattgcat gtggaagtgt tggagaatgt tccacttaca acacacaact ttgtacgaaa      780

aacgtttttc accttagcat tttgtgactt ttgtcgaaag ctgcttttcc agggtttccg      840

ctgtcaaaca tgtggttata aatttcacca gcgttgtagt acagaagttc cactgatgtg      900

tgttaattat gaccaacttg atttgctgtt tgtctccaag ttctttgaac accacccaat      960

accacaggaa gaggcgtcct tagcagagac tgccctaaca tctggatcat ccccttccgc     1020

acccgcctcg gactctattg ggccccaaat tctcaccagt ccgtctcctt caaaatccat     1080

tccaattcca cagcccttcc gaccagcaga tgaagatcat cgaaatcaat ttgggcaacg     1140

agaccgatcc tcatcagctc ccaatgtgca tataaacaca atagaacctg tcaatattga     1200

tgacttgatt agagaccaag gatttcgtgg tgatggagga tcaaccacag gtttgtctgc     1260

taccccccct gcctcattac ctggctcact aactaacgtg aaagccttac agaaatctcc     1320

aggacctcag cgagaaagga agtcatcttc atcctcagaa gacaggaatc gaatgaaaac     1380

acttggtaga cgggactcga gtgatgattg ggagattcct gatgggcaga ttacagtggg     1440

acaaagaatt ggatctggat catttggaac agtctacaag ggaaagtggc atggtgatgt     1500

ggcagtgaaa atgttgaatg tgacagcacc tacacctcag cagttacaag ccttcaaaaa     1560

tgaagtagga gtactcagga aaacacgaca tgtgaatatc ctactcttca tgggctattc     1620

cacaaagcca caactggcta ttgttaccca gtggtgtgag ggctccagct tgtatcacca     1680

tctccatatc attgagacca aatttgagat gatcaaactt atagatattg cacgacagac     1740

tgcacagggc atggattact tacacgccaa gtcaatcatc cacagagacc tcaagagtaa     1800

taatatattt cttcatgaag acctcacagt aaaaataggt gattttggtc tagctacagt     1860

gaaatctcga tggagtgggt cccatcagtt tgaacagttg tctggatcca ttttgtggat     1920

ggcaccagaa gtcatcagaa tgcaagataa aaatccatac agctttcagt cagatgtata     1980

tgcatttgga attgttctgt atgaattgat gactggacag ttaccttatt caaacatcaa     2040

caacagggac cagataattt ttatggtggg acgaggatac ctgtctccag atctcagtaa     2100

ggtacggagt aactgtccaa aagccatgaa gagattaatg gcagagtgcc tcaaaaagaa     2160

aagagatgag agaccactct ttccccaaat tctcgcctct attgagctgc tggcccgctc     2220

attgccaaaa attcaccgca gtgcatcaga accctccttg aatcgggctg gtttccaaac     2280

agaggatttt agtctatatg cttgtgcttc tccaaaaaca cccatccagg cagggggata     2340

tggtgcgttt cctgtccact gaaacaaatg agtgagagag ttcaggagag tagcaacaaa     2400

aggaaaataa atgaacatat gtttgcttat atgttaaatt gaataaaata ctctcttttt     2460

ttttaaggtg aaccaaagaa cacttgtgtg gttaaagact agatataatt tttccccaaa     2520

ctaaaattta tacttaacat tggattttta acatccaagg gttaaaatac atagacattg     2580

ctaaaaattg gcagagcctc ttctagaggc tttactttct gttccgggtt tgtatcattc     2640

acttggttat tttaagtagt aaacttcagt ttctcatgca acttttgttg ccagctatca     2700

catgtccact agggactcca gaagaagacc ctacctatgc ctgtgtttgc aggtgagaag     2760

ttggcagtcg gttagcctgg gttagataag gcaaactgaa cagatctaat ttaggaagtc     2820

agtagaattt aataattcta ttattattct taataatttt tctataacta tttcttttta     2880

taacaatttg gaaaatgtgg atgtctttta tttccttgaa gcaataaact aagtttcttt     2940

ttataaaaa                                                             2949


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
tgctcttgac ctcagactgg                                                   20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
cctcaataaa caccctacgg                                                   20


<210> 8
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
gaggctttgt cgaatcggac cggtg                                             25


<210> 9
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
ttgaacagag cctggcccgg ct                                                22


<210> 10
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
tgtgtctgtc catctgttta acagtca                                           27


<210> 11
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
gatagcctag tgcgagcaca ctctt                                             25


<210> 12
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
ccggcgatgg gctgattgtt acgaactcga gttcgtaaca atcagcccat cgttttt          57


