                         SEQUENCE LISTING

<110>  Applied Immune Technologies Ltd.
       PELED KAMAR, Mira
       DENKBERG, Galit
       REITER, Yoram
       BEER, Ilan
       SINIK, Keren
       TEBOUL (ELBAZ), Yael
       SHPERBER (SERY), Yael
       EREL SEGAL, Reut
       OREN, Ravit
       ALISHEKEVITZ, Dror Shmuel
 
<120>  T CELL RECEPTOR LIKE ANTIBODIES HAVING FINE SPECIFICITY

<130>  66428

<150>  US 62/172,264
<151>  2015-06-08

<150>  NL N2014935
<151>  2015-06-08

<160>  384   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  1

Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  2

Tyr Leu Leu Pro Ala Ile Val His Ile 
1               5                   


<210>  3
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  3

Thr Thr Ala Gly Cys Ala Ala Ala Gly Cys Ala Thr Ala Cys Cys Ala 
1               5                   10                  15      


Thr Cys Ala 
            


<210>  4
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  4

Cys Cys Ala Gly Ala Cys Ala Ala Ala Gly Ala Gly Gly Thr Cys Ala 
1               5                   10                  15      


Thr Ala Ala 
            


<210>  5
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  5

Ala Gly Gly Cys Thr Gly Cys Ala Ala Thr Ala Ala Gly Ala Gly Ala 
1               5                   10                  15      


Thr Ala 
        


<210>  6
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  6

Thr Thr Cys Gly Cys Thr Gly Ala Cys Ala Ala Gly Thr Thr Thr Thr 
1               5                   10                  15      


Ala Cys 
        


<210>  7
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  7

Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  8
<211>  163
<212>  PRT
<213>  homo sapiens

<400>  8

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  9
<211>  164
<212>  PRT
<213>  homo sapiens

<400>  9

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  10
<211>  123
<212>  PRT
<213>  homo sapiens

<400>  10

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  11
<211>  101
<212>  PRT
<213>  homo sapiens

<400>  11

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  12
<211>  220
<212>  PRT
<213>  homo sapiens

<400>  12

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  13
<211>  255
<212>  PRT
<213>  homo sapiens

<400>  13

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  14
<211>  199
<212>  PRT
<213>  homo sapiens

<400>  14

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  15
<211>  277
<212>  PRT
<213>  homo sapiens

<400>  15

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  16
<211>  184
<212>  PRT
<213>  homo sapiens

<400>  16

Met Ala Pro Leu Leu Pro Ile Arg Thr Leu Pro Leu Ile Leu Ile Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ser Pro Gly Ala Ala Asp Phe Asn Ile Ser Ser Leu 
            20                  25                  30          


Ser Gly Leu Leu Ser Pro Ala Leu Thr Glu Ser Leu Leu Val Ala Leu 
        35                  40                  45              


Pro Pro Cys His Leu Thr Gly Gly Asn Ala Thr Leu Met Val Arg Arg 
    50                  55                  60                  


Ala Asn Asp Ser Lys Val Val Thr Ser Ser Phe Val Val Pro Pro Cys 
65                  70                  75                  80  


Arg Gly Arg Arg Glu Leu Val Ser Val Val Asp Ser Gly Ala Gly Phe 
                85                  90                  95      


Thr Val Thr Arg Leu Ser Ala Tyr Gln Val Thr Asn Leu Val Pro Gly 
            100                 105                 110         


Thr Lys Phe Tyr Ile Ser Tyr Leu Val Lys Lys Gly Thr Ala Thr Glu 
        115                 120                 125             


Ser Ser Arg Glu Ile Pro Met Ser Thr Leu Pro Arg Arg Asn Met Glu 
    130                 135                 140                 


Ser Ile Gly Leu Gly Met Ala Arg Thr Gly Gly Met Val Val Ile Thr 
145                 150                 155                 160 


Val Leu Leu Ser Val Ala Met Phe Leu Leu Val Leu Gly Phe Ile Ile 
                165                 170                 175     


Ala Leu Ala Leu Gly Ser Arg Lys 
            180                 


<210>  17
<211>  273
<212>  PRT
<213>  homo sapiens

<400>  17

Met Ala Ser Ala Ala Ala Ala Glu Ala Glu Lys Gly Ser Pro Val Val 
1               5                   10                  15      


Val Gly Leu Leu Val Val Gly Asn Ile Ile Ile Leu Leu Ser Gly Leu 
            20                  25                  30          


Ser Leu Phe Ala Glu Thr Ile Trp Val Thr Ala Asp Gln Tyr Arg Val 
        35                  40                  45              


Tyr Pro Leu Met Gly Val Ser Gly Lys Asp Asp Val Phe Ala Gly Ala 
    50                  55                  60                  


Trp Ile Ala Ile Phe Cys Gly Phe Ser Phe Phe Met Val Ala Ser Phe 
65                  70                  75                  80  


Gly Val Gly Ala Ala Leu Cys Arg Arg Arg Ser Met Val Leu Thr Tyr 
                85                  90                  95      


Leu Val Leu Met Leu Ile Val Tyr Ile Phe Glu Cys Ala Ser Cys Ile 
            100                 105                 110         


Thr Ser Tyr Thr His Arg Asp Tyr Met Val Ser Asn Pro Ser Leu Ile 
        115                 120                 125             


Thr Lys Gln Met Leu Thr Phe Tyr Ser Ala Asp Thr Asp Gln Gly Gln 
    130                 135                 140                 


Glu Leu Thr Arg Leu Trp Asp Arg Val Met Ile Glu Gln Glu Cys Cys 
145                 150                 155                 160 


Gly Thr Ser Gly Pro Met Asp Trp Val Asn Phe Thr Ser Ala Phe Arg 
                165                 170                 175     


Ala Ala Thr Pro Glu Val Val Phe Pro Trp Pro Pro Leu Cys Cys Arg 
            180                 185                 190         


Arg Thr Gly Asn Phe Ile Pro Leu Asn Glu Glu Gly Cys Arg Leu Gly 
        195                 200                 205             


His Met Asp Tyr Leu Phe Thr Lys Ala Gly Val Gln Trp His Asn Leu 
    210                 215                 220                 


Ser Ser Leu Gln Arg Leu Pro Pro Gly Phe Lys Gly Phe Ser His Leu 
225                 230                 235                 240 


Ser Phe Gln Ser Ser Trp Asp Tyr Arg Ala Ala Ser Asn Thr Ser Ala 
                245                 250                 255     


Thr Pro Ser Thr Ala Thr Arg Gly Val Ser Arg Gly Leu Gly Leu Pro 
            260                 265                 270         


Ser 
    


<210>  18
<211>  258
<212>  PRT
<213>  homo sapiens

<400>  18

Met Ala Ser Ala Ala Ala Ala Glu Ala Glu Lys Gly Ser Pro Val Val 
1               5                   10                  15      


Val Gly Leu Leu Val Val Gly Asn Ile Ile Ile Leu Leu Ser Gly Leu 
            20                  25                  30          


Ser Leu Phe Ala Glu Thr Ile Trp Val Thr Ala Asp Gln Tyr Arg Val 
        35                  40                  45              


Tyr Pro Leu Met Gly Val Ser Gly Lys Asp Asp Val Phe Ala Gly Ala 
    50                  55                  60                  


Trp Ile Ala Ile Phe Cys Gly Phe Ser Phe Phe Met Val Ala Ser Phe 
65                  70                  75                  80  


Gly Val Gly Ala Ala Leu Cys Arg Arg Arg Ser Met Val Leu Thr Tyr 
                85                  90                  95      


Leu Val Leu Met Leu Ile Val Tyr Ile Phe Glu Cys Ala Ser Cys Ile 
            100                 105                 110         


Thr Ser Tyr Thr His Arg Asp Tyr Met Val Ser Asn Pro Ser Leu Ile 
        115                 120                 125             


Thr Lys Gln Met Leu Thr Phe Tyr Ser Ala Asp Thr Asp Gln Gly Gln 
    130                 135                 140                 


Glu Leu Thr Arg Leu Trp Asp Arg Val Met Ile Glu Gln Glu Cys Cys 
145                 150                 155                 160 


Gly Thr Ser Gly Pro Met Asp Trp Val Asn Phe Thr Ser Ala Phe Arg 
                165                 170                 175     


Ala Ala Thr Pro Glu Val Val Phe Pro Trp Pro Pro Leu Cys Cys Arg 
            180                 185                 190         


Arg Thr Gly Asn Phe Ile Pro Leu Asn Glu Glu Gly Cys Arg Leu Gly 
        195                 200                 205             


His Met Asp Tyr Leu Phe Thr Lys Gly Cys Phe Glu His Ile Gly His 
    210                 215                 220                 


Ala Ile Asp Ser Tyr Thr Trp Gly Ile Ser Trp Phe Gly Phe Ala Ile 
225                 230                 235                 240 


Leu Met Trp Thr Leu Pro Val Met Leu Ile Ala Met Tyr Phe Tyr Thr 
                245                 250                 255     


Met Leu 
        


<210>  19
<211>  245
<212>  PRT
<213>  homo sapiens

<400>  19

Met Lys Gln Ser Phe Pro Leu Phe Leu Thr Pro Ser Pro Trp Lys Thr 
1               5                   10                  15      


Thr Val Leu Leu Leu Tyr Met Arg Ile Cys Tyr Val Pro Ser Tyr Lys 
            20                  25                  30          


Trp Asn Tyr Ser Ile Gly Leu Ile Tyr Leu Gly Ile Val Ser Glu Leu 
        35                  40                  45              


Pro His Met Val Gly Ile Gly Gln Asn Ser Ser Phe Asn Ser Trp Met 
    50                  55                  60                  


Glu Ser Gln Phe Leu His Pro Ser Met Glu Pro Gly Gln Trp Leu Pro 
65                  70                  75                  80  


Tyr Ile Thr Ile Phe Arg Phe Thr His Ile Ile Arg Cys Val Arg Ile 
                85                  90                  95      


Ser Phe Leu Phe Asn Ile Pro Trp Tyr Gly Tyr Pro His Phe Val Cys 
            100                 105                 110         


His Ser Ser Val Ser Gly His Leu Gly Tyr Phe Tyr Leu Leu Leu Leu 
        115                 120                 125             


Trp Leu Val Cys Cys Glu His Arg Cys Thr Asn Ile Cys Ser Arg Gln 
    130                 135                 140                 


Thr Ser Phe Lys Arg Leu Phe Leu Lys Lys Tyr Val Ser Tyr Asn Ile 
145                 150                 155                 160 


Phe Leu Leu Cys Val Glu Ser Asp Ile Ser Ile Asp Leu Glu Gly Tyr 
                165                 170                 175     


Gly Met Gly Cys Thr Asn Ile Cys Ser Arg Gln Thr Ser Phe Lys Arg 
            180                 185                 190         


Leu Phe Lys Arg Lys Tyr Arg Cys Leu Leu Asn Met Phe Leu Val Met 
        195                 200                 205             


Asn Val Glu Ser Gly Thr Asn Arg Tyr Met Glu Val Arg Arg Ala Trp 
    210                 215                 220                 


Arg Gly Ser Lys Trp Glu Asp Glu Glu Asn Trp Leu Gly Ile Asp Val 
225                 230                 235                 240 


Tyr Phe Glu Asp Arg 
                245 


<210>  20
<211>  114
<212>  PRT
<213>  homo sapiens

<400>  20

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  21
<211>  386
<212>  PRT
<213>  homo sapiens

<400>  21

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  22
<211>  418
<212>  PRT
<213>  homo sapiens

<400>  22

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Val Leu Lys Val Ile 
    370                 375                 380                 


Phe Ala Val Ala Phe Cys Leu Ile Ser Ala Val Leu Met Val Leu Leu 
385                 390                 395                 400 


Phe Ile His Ile Arg Arg Gly Leu Cys Trp Gln Arg Glu Ser Tyr Gly 
                405                 410                 415     


Asn Ile 
        


<210>  23
<211>  353
<212>  PRT
<213>  homo sapiens

<400>  23

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Asp Phe Ile Ala Thr Leu Gly Lys 
145                 150                 155                 160 


Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val 
                165                 170                 175     


Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro Ser 
            180                 185                 190         


Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu Leu 
        195                 200                 205             


Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser Arg 
    210                 215                 220                 


Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys Arg 
225                 230                 235                 240 


Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala His 
                245                 250                 255     


Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn Gly 
            260                 265                 270         


Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe Glu 
        275                 280                 285             


Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln His 
    290                 295                 300                 


Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro Leu 
305                 310                 315                 320 


Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp Ser 
                325                 330                 335     


Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser Thr 
            340                 345                 350         


Asp 
    


<210>  24
<211>  335
<212>  PRT
<213>  homo sapiens

<400>  24

Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Ile Phe Pro Gly Asn Trp Asp Asn His Ser His Lys Lys Asn 
    290                 295                 300                 


Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg Ile Leu Pro Val 
305                 310                 315                 320 


Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu Leu Gly Cys 
                325                 330                 335 


<210>  25
<211>  264
<212>  PRT
<213>  homo sapiens

<400>  25

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
145                 150                 155                 160 


Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val 
                165                 170                 175     


Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val 
            180                 185                 190         


Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
        195                 200                 205             


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
    210                 215                 220                 


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
225                 230                 235                 240 


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
                245                 250                 255     


Val Ala Ala Thr Ser Ala Asn Leu 
            260                 


<210>  26
<211>  203
<212>  PRT
<213>  homo sapiens

<400>  26

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Ser Asp Val Pro Phe Pro Phe 
                85                  90                  95      


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
            100                 105                 110         


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
        115                 120                 125             


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
    130                 135                 140                 


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
145                 150                 155                 160 


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
                165                 170                 175     


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
            180                 185                 190         


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        195                 200             


<210>  27
<211>  159
<212>  PRT
<213>  homo sapiens

<400>  27

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                85                  90                  95      


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            100                 105                 110         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        115                 120                 125             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    130                 135                 140                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
145                 150                 155                 


<210>  28
<211>  475
<212>  PRT
<213>  homo sapiens

<400>  28

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His 
                165                 170                 175     


Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 
            180                 185                 190         


Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 
        195                 200                 205             


Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr 
    210                 215                 220                 


Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser 
225                 230                 235                 240 


Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu 
                245                 250                 255     


Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu 
            260                 265                 270         


Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 
        275                 280                 285             


Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly 
    290                 295                 300                 


Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val 
305                 310                 315                 320 


Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
                325                 330                 335     


Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
            340                 345                 350         


Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe 
        355                 360                 365             


Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu 
    370                 375                 380                 


Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala 
385                 390                 395                 400 


Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile 
                405                 410                 415     


Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr 
            420                 425                 430         


His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro 
        435                 440                 445             


Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr 
    450                 455                 460                 


Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
465                 470                 475 


<210>  29
<211>  282
<212>  PRT
<213>  homo sapiens

<400>  29

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly 
            100                 105                 110         


Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val 
        115                 120                 125             


Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val 
    130                 135                 140                 


Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn 
145                 150                 155                 160 


Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser 
                165                 170                 175     


Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val 
            180                 185                 190         


Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu 
        195                 200                 205             


Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe 
    210                 215                 220                 


Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His 
225                 230                 235                 240 


Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr 
                245                 250                 255     


Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn 
            260                 265                 270         


Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
        275                 280         


<210>  30
<211>  238
<212>  PRT
<213>  homo sapiens

<400>  30

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr 
    50                  55                  60                  


Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly 
65                  70                  75                  80  


Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
                85                  90                  95      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            100                 105                 110         


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        115                 120                 125             


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile 
    130                 135                 140                 


Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr 
145                 150                 155                 160 


Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 
                165                 170                 175     


Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 
            180                 185                 190         


Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 
        195                 200                 205             


Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 
    210                 215                 220                 


Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235             


<210>  31
<211>  241
<212>  PRT
<213>  homo sapiens

<400>  31

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Leu 
    50                  55                  60                  


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
65                  70                  75                  80  


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
                85                  90                  95      


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
            100                 105                 110         


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
        115                 120                 125             


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
    130                 135                 140                 


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
145                 150                 155                 160 


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
                165                 170                 175     


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
            180                 185                 190         


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
        195                 200                 205             


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
    210                 215                 220                 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
225                 230                 235                 240 


Leu 
    


<210>  32
<211>  198
<212>  PRT
<213>  homo sapiens

<400>  32

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Gly Cys 
145                 150                 155                 160 


Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala Gly His Leu Ser Ser 
                165                 170                 175     


Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro His Leu Pro His Pro 
            180                 185                 190         


Trp Ala Leu Cys Ala Pro 
        195             


<210>  33
<211>  189
<212>  PRT
<213>  homo sapiens

<400>  33

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala 
                85                  90                  95      


Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu 
            100                 105                 110         


Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu 
        115                 120                 125             


Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro 
    130                 135                 140                 


Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg 
145                 150                 155                 160 


Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser 
                165                 170                 175     


Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
            180                 185                 


<210>  34
<211>  177
<212>  PRT
<213>  homo sapiens

<400>  34

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Leu Ser 
    50                  55                  60                  


Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 
65                  70                  75                  80  


Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu 
                85                  90                  95      


Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln Cys Arg Arg Lys Asn 
            100                 105                 110         


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
        115                 120                 125             


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
    130                 135                 140                 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
145                 150                 155                 160 


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
                165                 170                 175     


Leu 
    


<210>  35
<211>  255
<212>  PRT
<213>  homo sapiens

<400>  35

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile 
65                  70                  75                  80  


Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro 
                85                  90                  95      


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
            100                 105                 110         


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
        115                 120                 125             


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
    130                 135                 140                 


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
145                 150                 155                 160 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
                165                 170                 175     


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
            180                 185                 190         


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
        195                 200                 205             


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
    210                 215                 220                 


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
225                 230                 235                 240 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
                245                 250                 255 


<210>  36
<211>  150
<212>  PRT
<213>  homo sapiens

<400>  36

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp 
    50                  55                  60                  


Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Ala Val Cys Gln 
65                  70                  75                  80  


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                85                  90                  95      


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            100                 105                 110         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        115                 120                 125             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    130                 135                 140                 


Ala Thr Ser Ala Asn Leu 
145                 150 


<210>  37
<211>  158
<212>  PRT
<213>  homo sapiens

<400>  37

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Cys Phe Cys Arg Phe Ile Asn Lys Gly Val Phe 
65                  70                  75                  80  


Trp Ala Ser Pro Ile Leu Ser Ser Val Trp Gly Trp Gly Ala Arg Leu 
                85                  90                  95      


Gly His Arg Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His 
            100                 105                 110         


Cys Leu Ser His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu 
        115                 120                 125             


Arg Ala Ala Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu 
    130                 135                 140                 


Arg Val Pro His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
145                 150                 155             


<210>  38
<211>  484
<212>  PRT
<213>  homo sapiens

<400>  38

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser 
    50                  55                  60                  


Met Thr Ser Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser 
65                  70                  75                  80  


Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala 
                85                  90                  95      


Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val 
            100                 105                 110         


Thr Arg Pro Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr 
        115                 120                 125             


Ser Ala Pro Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
    130                 135                 140                 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn Arg Pro Ala 
                165                 170                 175     


Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser Ala Ser Gly 
            180                 185                 190         


Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 
        195                 200                 205             


Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 
    210                 215                 220                 


Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 
225                 230                 235                 240 


Thr Asp Ala Ser Ser Thr His His Ser Thr Val Pro Pro Leu Thr Ser 
                245                 250                 255     


Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 
            260                 265                 270         


Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 
        275                 280                 285             


Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 
    290                 295                 300                 


Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 
305                 310                 315                 320 


Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 
                325                 330                 335     


Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 
            340                 345                 350         


Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 
        355                 360                 365             


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    370                 375                 380                 


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
385                 390                 395                 400 


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
                405                 410                 415     


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
            420                 425                 430         


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
        435                 440                 445             


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
    450                 455                 460                 


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
465                 470                 475                 480 


Ser Ala Asn Leu 
                


<210>  39
<211>  219
<212>  PRT
<213>  homo sapiens

<400>  39

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn 
    50                  55                  60                  


Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg 
65                  70                  75                  80  


Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu 
                85                  90                  95      


Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu 
            100                 105                 110         


Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr 
        115                 120                 125             


Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
    130                 135                 140                 


Ile Ser Asp Val Ser Val Trp Gly Trp Gly Ala Arg Leu Gly His Arg 
145                 150                 155                 160 


Ala Ala Gly Ala Gly Leu Cys Ser Gly Cys Ala Gly His Cys Leu Ser 
                165                 170                 175     


His Cys Leu Gly Cys Leu Ser Val Pro Pro Lys Glu Leu Arg Ala Ala 
            180                 185                 190         


Gly His Leu Ser Ser Pro Gly Tyr Leu Pro Ser Tyr Glu Arg Val Pro 
        195                 200                 205             


His Leu Pro His Pro Trp Ala Leu Cys Ala Pro 
    210                 215                 


<210>  40
<211>  217
<212>  PRT
<213>  homo sapiens

<400>  40

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser 
            20                  25                  30          


Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Tyr Lys Gln Gly Gly Phe 
        35                  40                  45              


Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln 
    50                  55                  60                  


Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu 
65                  70                  75                  80  


Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu 
                85                  90                  95      


Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala 
            100                 105                 110         


Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu 
        115                 120                 125             


Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala 
    130                 135                 140                 


Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro 
145                 150                 155                 160 


Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr 
                165                 170                 175     


His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu 
            180                 185                 190         


Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro 
        195                 200                 205             


Ala Val Ala Ala Thr Ser Ala Asn Leu 
    210                 215         


<210>  41
<211>  239
<212>  PRT
<213>  homo sapiens

<400>  41

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Trp Pro 
65                  70                  75                  80  


Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile 
                85                  90                  95      


Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
            100                 105                 110         


Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
        115                 120                 125             


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly 
    130                 135                 140                 


Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val 
145                 150                 155                 160 


Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly 
                165                 170                 175     


Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu 
            180                 185                 190         


Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr 
        195                 200                 205             


Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser 
    210                 215                 220                 


Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
225                 230                 235                 


<210>  42
<211>  230
<212>  PRT
<213>  homo sapiens

<400>  42

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Ile Pro Ala Pro Thr Thr Thr Lys Ser Cys Arg 
    50                  55                  60                  


Glu Thr Phe Leu Lys Trp Pro Gly Ser Val Val Val Gln Leu Thr Leu 
65                  70                  75                  80  


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
                85                  90                  95      


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 
            100                 105                 110         


Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 
        115                 120                 125             


Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val 
    130                 135                 140                 


Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln 
145                 150                 155                 160 


Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp 
                165                 170                 175     


Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg 
            180                 185                 190         


Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 
        195                 200                 205             


Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala 
    210                 215                 220                 


Ala Thr Ser Ala Asn Leu 
225                 230 


<210>  43
<211>  212
<212>  PRT
<213>  homo sapiens

<400>  43

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Ala Thr Thr Ala Pro Lys Pro Ala Thr Val Val Thr Gly 
            20                  25                  30          


Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala 
        35                  40                  45              


Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Ile Pro 
    50                  55                  60                  


Ala Pro Thr Thr Thr Lys Ser Cys Arg Glu Thr Phe Leu Lys Cys Phe 
65                  70                  75                  80  


Cys Arg Phe Ile Asn Lys Gly Val Phe Trp Ala Ser Pro Ile Leu Ser 
                85                  90                  95      


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
            100                 105                 110         


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
        115                 120                 125             


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
    130                 135                 140                 


Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 
145                 150                 155                 160 


His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val 
                165                 170                 175     


Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly 
            180                 185                 190         


Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr 
        195                 200                 205             


Ser Ala Asn Leu 
    210         


<210>  44
<211>  273
<212>  PRT
<213>  homo sapiens

<400>  44

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  45
<211>  575
<212>  PRT
<213>  homo sapiens

<400>  45

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Gly Ser Gln Val Trp Gly Gly 
            20                  25                  30          


Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp 
        35                  40                  45              


Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val 
    50                  55                  60                  


Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro 
65                  70                  75                  80  


Val Ser Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His 
                85                  90                  95      


Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val 
            100                 105                 110         


Pro Leu Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro 
        115                 120                 125             


Phe Ser Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys 
    130                 135                 140                 


His Phe Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp 
145                 150                 155                 160 


Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe 
                165                 170                 175     


Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His 
            180                 185                 190         


Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala 
        195                 200                 205             


Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr 
    210                 215                 220                 


Asp Gly His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr Ala Gly Gln 
225                 230                 235                 240 


Val Pro Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Ala Pro Thr 
                245                 250                 255     


Ala Glu Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val 
            260                 265                 270         


Ile Ser Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Met 
        275                 280                 285             


Thr Pro Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala 
    290                 295                 300                 


Glu Met Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala Glu Val Ser 
305                 310                 315                 320 


Ile Val Val Leu Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu 
                325                 330                 335     


Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly 
            340                 345                 350         


Pro Asp Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu 
        355                 360                 365             


Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln 
    370                 375                 380                 


Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr 
385                 390                 395                 400 


Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val 
                405                 410                 415     


Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly 
            420                 425                 430         


Gly Leu Pro Lys Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln 
        435                 440                 445             


Pro Pro Ala Gln Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys 
    450                 455                 460                 


Gln Leu Val Leu His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys 
465                 470                 475                 480 


Leu Asn Val Ser Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr 
                485                 490                 495     


Gln Leu Ile Met Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu 
            500                 505                 510         


Ile Val Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu 
        515                 520                 525             


Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu 
    530                 535                 540                 


Pro His Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser 
545                 550                 555                 560 


Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
                565                 570                 575 


<210>  46
<211>  661
<212>  PRT
<213>  homo sapiens

<400>  46

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  47
<211>  668
<212>  PRT
<213>  homo sapiens

<400>  47

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Val Pro Gly Ile Leu 
            580                 585                 590         


Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly 
        595                 600                 605             


Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr Arg 
    610                 615                 620                 


Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His Ser 
625                 630                 635                 640 


Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro Ile 
                645                 650                 655     


Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
            660                 665             


<210>  48
<211>  118
<212>  PRT
<213>  homo sapiens

<400>  48

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  49
<211>  1069
<212>  PRT
<213>  homo sapiens

<400>  49

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                885                 890                 895     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            900                 905                 910         


Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val 
        915                 920                 925             


Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu 
    930                 935                 940                 


Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln 
945                 950                 955                 960 


Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr 
                965                 970                 975     


Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser 
            980                 985                 990         


Leu Gly Ala Lys Gly Ala Ala Gly  Pro Leu Pro Ser Glu  Ala Val Gln 
        995                 1000                 1005             


Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys Leu Thr  Arg His Arg 
    1010                 1015                 1020             


Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu Arg Thr  Ala Gln Thr 
    1025                 1030                 1035             


Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr Leu Thr  Ala Leu Glu 
    1040                 1045                 1050             


Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp Phe Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp 
    


<210>  50
<211>  1132
<212>  PRT
<213>  homo sapiens

<400>  50

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  51
<211>  353
<212>  PRT
<213>  homo sapiens

<400>  51

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Phe Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Gly Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Ile 
    50                  55                  60                  


Gly Ser Ala Leu Gln Phe Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Ile Thr His 
                85                  90                  95      


Thr Thr Pro Asn Ile Pro Pro Ser Phe Leu Gln Ala Met Arg Lys Tyr 
            100                 105                 110         


Ser Pro Phe Arg Asn Gly Tyr Met Glu Pro Thr Leu Gly Gln His Leu 
        115                 120                 125             


Pro Thr Leu Ser Phe Pro Asp Pro Gly Leu Arg Pro Gln Asn Leu Tyr 
    130                 135                 140                 


Thr Leu Trp Gly Gly Ser Val Val Cys Met Tyr Leu Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Ile Thr Trp Pro Leu Leu Pro His Val Ile Phe Cys His Pro 
                165                 170                 175     


Gly Gln Leu Gly Ala Phe Leu Thr Asn Val Pro Tyr Lys Arg Ile Glu 
            180                 185                 190         


Lys Leu Leu Tyr Lys Ile Ser Leu Thr Thr Gly Ala Leu Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Cys Leu Pro Thr Thr Leu Phe Gln Pro Ala Arg Ala Pro 
    210                 215                 220                 


Val Thr Leu Thr Ala Trp Gln Asn Gly Leu Leu Pro Phe His Ser Thr 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Thr Asp Gly Thr Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Asp Gly Gln Pro Ser Leu Val Leu Gln 
            260                 265                 270         


Ser Ser Ser Phe Ile Phe His Lys Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Phe Leu Leu Ser His Gly Leu Ile Gln Tyr Ser Ser Phe His Asn 
    290                 295                 300                 


Leu His Leu Leu Phe Glu Glu Tyr Thr Asn Ile Pro Ile Ser Leu Leu 
305                 310                 315                 320 


Phe Asn Glu Lys Glu Ala Asp Asp Asn Asp His Glu Pro Gln Ile Ser 
                325                 330                 335     


Pro Gly Gly Leu Glu Pro Leu Ser Glu Lys His Phe Arg Glu Thr Glu 
            340                 345                 350         


Val 
    


<210>  52
<211>  345
<212>  PRT
<213>  homo sapiens

<400>  52

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Tyr Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Ala Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Pro Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Val 
    50                  55                  60                  


Gly Ser Pro Leu Gln Tyr Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Thr Thr Pro 
                85                  90                  95      


Val Thr Pro Lys Val Pro Pro Ser Phe Phe Gln Ser Val Arg Arg His 
            100                 105                 110         


Ser Pro Tyr Arg Asn Gly Cys Leu Glu Thr Thr Leu Gly Glu Gln Leu 
        115                 120                 125             


Pro Ser Leu Ala Phe Pro Glu Pro Gly Leu Arg Pro Gln Asn Val Tyr 
    130                 135                 140                 


Thr Ile Trp Gly Lys Thr Ile Val Cys Leu Tyr Ile Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Met Thr Trp Pro Leu Ile Pro His Val Ile Phe Cys Asn Pro 
                165                 170                 175     


Arg Gln Leu Gly Ala Phe Leu Ser Asn Val Pro Pro Lys Arg Leu Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Leu Tyr Leu His Thr Gly Ala Ile Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Ala Leu Pro Thr Thr Leu Phe Gln Pro Val Arg Ala Pro 
    210                 215                 220                 


Cys Val Gln Thr Thr Trp Asn Thr Gly Leu Leu Pro Tyr Gln Pro Asn 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Asn Asp Gly Ser Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Ala Gly Gln Pro Ser Leu Val Val Gln 
            260                 265                 270         


Ser Ser Leu Leu Ile Phe Glu Arg Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Tyr Leu Leu Ser His Gln Leu Ile Gln Tyr Ser Ser Phe His His 
    290                 295                 300                 


Leu Tyr Leu Leu Phe Asp Glu Tyr Thr Thr Ile Pro Phe Ser Leu Leu 
305                 310                 315                 320 


Phe Lys Glu Lys Glu Gly Asp Asp Arg Asp Asn Asp Pro Leu Pro Gly 
                325                 330                 335     


Ala Thr Ala Ser Pro Gln Gly Gln Asn 
            340                 345 


<210>  53
<211>  180
<212>  PRT
<213>  homo sapiens

<400>  53

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  54
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  54

Met Ser Leu Glu Gln Arg Ser Leu His Cys Lys Pro Glu Glu Ala Leu 
1               5                   10                  15      


Glu Ala Gln Gln Glu Ala Leu Gly Leu Val Cys Val Gln Ala Ala Thr 
            20                  25                  30          


Ser Ser Ser Ser Pro Leu Val Leu Gly Thr Leu Glu Glu Val Pro Thr 
        35                  40                  45              


Ala Gly Ser Thr Asp Pro Pro Gln Ser Pro Gln Gly Ala Ser Ala Phe 
    50                  55                  60                  


Pro Thr Thr Ile Asn Phe Thr Arg Gln Arg Gln Pro Ser Glu Gly Ser 
65                  70                  75                  80  


Ser Ser Arg Glu Glu Glu Gly Pro Ser Thr Ser Cys Ile Leu Glu Ser 
                85                  90                  95      


Leu Phe Arg Ala Val Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
            100                 105                 110         


Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu Met 
        115                 120                 125             


Leu Glu Ser Val Ile Lys Asn Tyr Lys His Cys Phe Pro Glu Ile Phe 
    130                 135                 140                 


Gly Lys Ala Ser Glu Ser Leu Gln Leu Val Phe Gly Ile Asp Val Lys 
145                 150                 155                 160 


Glu Ala Asp Pro Thr Gly His Ser Tyr Val Leu Val Thr Cys Leu Gly 
                165                 170                 175     


Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn Gln Ile Met Pro Lys Thr 
            180                 185                 190         


Gly Phe Leu Ile Ile Val Leu Val Met Ile Ala Met Glu Gly Gly His 
        195                 200                 205             


Ala Pro Glu Glu Glu Ile Trp Glu Glu Leu Ser Val Met Glu Val Tyr 
    210                 215                 220                 


Asp Gly Arg Glu His Ser Ala Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
225                 230                 235                 240 


Gln Asp Leu Val Gln Glu Lys Tyr Leu Glu Tyr Arg Gln Val Pro Asp 
                245                 250                 255     


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala 
            260                 265                 270         


Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr Val Ile Lys Val Ser Ala 
        275                 280                 285             


Arg Val Arg Phe Phe Phe Pro Ser Leu Arg Glu Ala Ala Leu Arg Glu 
    290                 295                 300                 


Glu Glu Glu Gly Val 
305                 


<210>  55
<211>  314
<212>  PRT
<213>  homo sapiens

<400>  55

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  56
<211>  1225
<212>  PRT
<213>  homo sapiens

<400>  56

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  57
<211>  1240
<212>  PRT
<213>  homo sapiens

<400>  57

Met Pro Arg Gly Ser Trp Lys Pro Gln Val Cys Thr Gly Thr Asp Met 
1               5                   10                  15      


Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg 
            20                  25                  30          


His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr 
        35                  40                  45              


Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu 
    50                  55                  60                  


Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro 
65                  70                  75                  80  


Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn 
                85                  90                  95      


Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr 
            100                 105                 110         


Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg 
        115                 120                 125             


Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro 
    130                 135                 140                 


Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys 
145                 150                 155                 160 


Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala 
                165                 170                 175     


Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu 
            180                 185                 190         


Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly 
        195                 200                 205             


Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln 
    210                 215                 220                 


Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys 
225                 230                 235                 240 


Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu 
                245                 250                 255     


Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly 
            260                 265                 270         


Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr 
        275                 280                 285             


Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn 
    290                 295                 300                 


Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser 
305                 310                 315                 320 


Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg 
                325                 330                 335     


Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys 
            340                 345                 350         


Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly 
        355                 360                 365             


Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val 
    370                 375                 380                 


Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp 
385                 390                 395                 400 


Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile 
                405                 410                 415     


Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly 
            420                 425                 430         


Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser 
        435                 440                 445             


Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr 
    450                 455                 460                 


Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His 
465                 470                 475                 480 


Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys 
                485                 490                 495     


His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln 
            500                 505                 510         


Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu 
        515                 520                 525             


Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His 
    530                 535                 540                 


Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr 
545                 550                 555                 560 


Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys 
                565                 570                 575     


Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp 
            580                 585                 590         


Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys 
        595                 600                 605             


Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp 
    610                 615                 620                 


Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile 
625                 630                 635                 640 


Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe 
                645                 650                 655     


Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met 
            660                 665                 670         


Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser 
        675                 680                 685             


Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu 
    690                 695                 700                 


Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
705                 710                 715                 720 


Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala 
                725                 730                 735     


Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile 
            740                 745                 750         


Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser 
        755                 760                 765             


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln 
    770                 775                 780                 


Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly 
785                 790                 795                 800 


Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys 
                805                 810                 815     


Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala 
            820                 825                 830         


Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp 
        835                 840                 845             


Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala 
    850                 855                 860                 


Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
865                 870                 875                 880 


Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
                885                 890                 895     


Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro 
            900                 905                 910         


Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln 
        915                 920                 925             


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
    930                 935                 940                 


Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu 
945                 950                 955                 960 


Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn 
                965                 970                 975     


Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser 
            980                 985                 990         


Leu Leu Glu Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
        995                 1000                 1005             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1010                 1015                 1020             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1025                 1030                 1035             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1040                 1045                 1050             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1055                 1060                 1065             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1070                 1075                 1080             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1085                 1090                 1095             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1100                 1105                 1110             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1115                 1120                 1125             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1130                 1135                 1140             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1145                 1150                 1155             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1160                 1165                 1170             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1175                 1180                 1185             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1190                 1195                 1200             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1205                 1210                 1215             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1220                 1225                 1230             


Leu Gly  Leu Asp Val Pro Val  
    1235                 1240 


<210>  58
<211>  1055
<212>  PRT
<213>  homo sapiens

<400>  58

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Asn Met  
    1055 


<210>  59
<211>  603
<212>  PRT
<213>  homo sapiens

<400>  59

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser 
        595                 600             


<210>  60
<211>  1255
<212>  PRT
<213>  homo sapiens

<400>  60

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  61
<211>  781
<212>  PRT
<213>  homo sapiens

<400>  61

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  62
<211>  781
<212>  PRT
<213>  homo sapiens

<400>  62

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  63
<211>  781
<212>  PRT
<213>  homo sapiens

<400>  63

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  64
<211>  529
<212>  PRT
<213>  homo sapiens

<400>  64

Met Leu Leu Ala Val Leu Tyr Cys Leu Leu Trp Ser Phe Gln Thr Ser 
1               5                   10                  15      


Ala Gly His Phe Pro Arg Ala Cys Val Ser Ser Lys Asn Leu Met Glu 
            20                  25                  30          


Lys Glu Cys Cys Pro Pro Trp Ser Gly Asp Arg Ser Pro Cys Gly Gln 
        35                  40                  45              


Leu Ser Gly Arg Gly Ser Cys Gln Asn Ile Leu Leu Ser Asn Ala Pro 
    50                  55                  60                  


Leu Gly Pro Gln Phe Pro Phe Thr Gly Val Asp Asp Arg Glu Ser Trp 
65                  70                  75                  80  


Pro Ser Val Phe Tyr Asn Arg Thr Cys Gln Cys Ser Gly Asn Phe Met 
                85                  90                  95      


Gly Phe Asn Cys Gly Asn Cys Lys Phe Gly Phe Trp Gly Pro Asn Cys 
            100                 105                 110         


Thr Glu Arg Arg Leu Leu Val Arg Arg Asn Ile Phe Asp Leu Ser Ala 
        115                 120                 125             


Pro Glu Lys Asp Lys Phe Phe Ala Tyr Leu Thr Leu Ala Lys His Thr 
    130                 135                 140                 


Ile Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr Gly Gln Met Lys 
145                 150                 155                 160 


Asn Gly Ser Thr Pro Met Phe Asn Asp Ile Asn Ile Tyr Asp Leu Phe 
                165                 170                 175     


Val Trp Met His Tyr Tyr Val Ser Met Asp Ala Leu Leu Gly Gly Ser 
            180                 185                 190         


Glu Ile Trp Arg Asp Ile Asp Phe Ala His Glu Ala Pro Ala Phe Leu 
        195                 200                 205             


Pro Trp His Arg Leu Phe Leu Leu Arg Trp Glu Gln Glu Ile Gln Lys 
    210                 215                 220                 


Leu Thr Gly Asp Glu Asn Phe Thr Ile Pro Tyr Trp Asp Trp Arg Asp 
225                 230                 235                 240 


Ala Glu Lys Cys Asp Ile Cys Thr Asp Glu Tyr Met Gly Gly Gln His 
                245                 250                 255     


Pro Thr Asn Pro Asn Leu Leu Ser Pro Ala Ser Phe Phe Ser Ser Trp 
            260                 265                 270         


Gln Ile Val Cys Ser Arg Leu Glu Glu Tyr Asn Ser His Gln Ser Leu 
        275                 280                 285             


Cys Asn Gly Thr Pro Glu Gly Pro Leu Arg Arg Asn Pro Gly Asn His 
    290                 295                 300                 


Asp Lys Ser Arg Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
305                 310                 315                 320 


Cys Leu Ser Leu Thr Gln Tyr Glu Ser Gly Ser Met Asp Lys Ala Ala 
                325                 330                 335     


Asn Phe Ser Phe Arg Asn Thr Leu Glu Gly Phe Ala Ser Pro Leu Thr 
            340                 345                 350         


Gly Ile Ala Asp Ala Ser Gln Ser Ser Met His Asn Ala Leu His Ile 
        355                 360                 365             


Tyr Met Asn Gly Thr Met Ser Gln Val Gln Gly Ser Ala Asn Asp Pro 
    370                 375                 380                 


Ile Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp 
385                 390                 395                 400 


Leu Arg Arg His Arg Pro Leu Gln Glu Val Tyr Pro Glu Ala Asn Ala 
                405                 410                 415     


Pro Ile Gly His Asn Arg Glu Ser Tyr Met Val Pro Phe Ile Pro Leu 
            420                 425                 430         


Tyr Arg Asn Gly Asp Phe Phe Ile Ser Ser Lys Asp Leu Gly Tyr Asp 
        435                 440                 445             


Tyr Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp Tyr Ile 
    450                 455                 460                 


Lys Ser Tyr Leu Glu Gln Ala Ser Arg Ile Trp Ser Trp Leu Leu Gly 
465                 470                 475                 480 


Ala Ala Met Val Gly Ala Val Leu Thr Ala Leu Leu Ala Gly Leu Val 
                485                 490                 495     


Ser Leu Leu Cys Arg His Lys Arg Lys Gln Leu Pro Glu Glu Lys Gln 
            500                 505                 510         


Pro Leu Leu Met Glu Lys Glu Asp Tyr His Ser Leu Tyr Gln Ser His 
        515                 520                 525             


Leu 
    


<210>  65
<211>  693
<212>  PRT
<213>  homo sapiens

<400>  65

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr 
    690             


<210>  66
<211>  464
<212>  PRT
<213>  homo sapiens

<400>  66

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
            180                 185                 190         


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
        195                 200                 205             


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
    210                 215                 220                 


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
225                 230                 235                 240 


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
                245                 250                 255     


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
            260                 265                 270         


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
        275                 280                 285             


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
    290                 295                 300                 


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
305                 310                 315                 320 


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
                325                 330                 335     


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
            340                 345                 350         


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
        355                 360                 365             


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
    370                 375                 380                 


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
385                 390                 395                 400 


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
                405                 410                 415     


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
            420                 425                 430         


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
        435                 440                 445             


Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


<210>  67
<211>  538
<212>  PRT
<213>  homo sapiens

<400>  67

Met Glu Gly Gly Arg Arg Ala Arg Val Val Ile Glu Ser Lys Arg Asn 
1               5                   10                  15      


Phe Phe Leu Gly Ala Phe Pro Thr Pro Phe Pro Ala Glu His Val Glu 
            20                  25                  30          


Leu Gly Arg Leu Gly Asp Ser Glu Thr Ala Met Val Pro Gly Lys Gly 
        35                  40                  45              


Gly Ala Asp Tyr Ile Leu Leu Pro Phe Lys Lys Met Asp Phe Ser Arg 
    50                  55                  60                  


Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser Glu Asp Leu Ala Ser 
65                  70                  75                  80  


Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln Arg Lys Gln Glu Pro 
                85                  90                  95      


Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu Gln Glu Lys Arg Met 
            100                 105                 110         


Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu Leu Leu Phe Arg Ile 
        115                 120                 125             


Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn Thr Arg Lys Glu Glu 
    130                 135                 140                 


Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala Gln Ile Ser Ala Tyr 
145                 150                 155                 160 


Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val Ser Arg Ser Glu Leu 
                165                 170                 175     


Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile Ser Lys Cys Lys Leu 
            180                 185                 190         


Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile Glu Met Glu Lys Arg 
        195                 200                 205             


Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu Lys Arg Val Cys Ala 
    210                 215                 220                 


Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn Asp Tyr Glu Glu Phe 
225                 230                 235                 240 


Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser Pro Asp Glu Phe Ser 
                245                 250                 255     


Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile Ser Asp Ser Pro Arg 
            260                 265                 270         


Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys Val Tyr Gln Met Lys 
        275                 280                 285             


Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala 
    290                 295                 300                 


Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn 
305                 310                 315                 320 


Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr Thr Phe Glu Glu Leu 
                325                 330                 335     


His Phe Glu Ile Lys Pro His Asp Asp Cys Thr Val Glu Gln Ile Tyr 
            340                 345                 350         


Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp Cys 
        355                 360                 365             


Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr Gly 
    370                 375                 380                 


Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe Thr 
385                 390                 395                 400 


Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe Ile 
                405                 410                 415     


Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu Thr 
            420                 425                 430         


Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp Leu Ser Ser Pro Gln 
        435                 440                 445             


Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala Thr 
    450                 455                 460                 


Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Thr Trp Tyr 
465                 470                 475                 480 


Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly Asp 
                485                 490                 495     


Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr Glu Val Ser Asn Lys 
            500                 505                 510         


Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Thr Phe Thr 
        515                 520                 525             


Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    530                 535             


<210>  68
<211>  496
<212>  PRT
<213>  homo sapiens

<400>  68

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Phe His Phe Cys Arg Met Ser Trp Ala Glu 
            100                 105                 110         


Ala Asn Ser Gln Cys Gln Thr Gln Ser Val Pro Phe Trp Arg Arg Val 
        115                 120                 125             


Asp His Leu Leu Ile Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
    130                 135                 140                 


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
145                 150                 155                 160 


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
                165                 170                 175     


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
            180                 185                 190         


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
        195                 200                 205             


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
    210                 215                 220                 


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
225                 230                 235                 240 


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
                245                 250                 255     


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
            260                 265                 270         


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
        275                 280                 285             


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
    290                 295                 300                 


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
305                 310                 315                 320 


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
                325                 330                 335     


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
            340                 345                 350         


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
        355                 360                 365             


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
    370                 375                 380                 


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
385                 390                 395                 400 


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
                405                 410                 415     


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
            420                 425                 430         


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
        435                 440                 445             


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
    450                 455                 460                 


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
465                 470                 475                 480 


Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
                485                 490                 495     


<210>  69
<211>  479
<212>  PRT
<213>  homo sapiens

<400>  69

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn Gly Glu Glu Leu Cys Gly Val Met Thr Ile 
        195                 200                 205             


Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp Lys 
    210                 215                 220                 


Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn 
225                 230                 235                 240 


Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His Ser 
                245                 250                 255     


Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr Thr 
            260                 265                 270         


Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys Thr 
        275                 280                 285             


Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp His 
    290                 295                 300                 


Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp Lys 
305                 310                 315                 320 


Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu 
                325                 330                 335     


Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly 
        355                 360                 365             


Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met Asp 
    370                 375                 380                 


Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu 
385                 390                 395                 400 


Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala 
                405                 410                 415     


Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg 
            420                 425                 430         


Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr 
        435                 440                 445             


Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met Pro 
    450                 455                 460                 


Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
465                 470                 475                 


<210>  70
<211>  464
<212>  PRT
<213>  homo sapiens

<400>  70

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Gly Glu Glu Leu Cys Gly Val Met Thr 
            180                 185                 190         


Ile Ser Asp Ser Pro Arg Glu Gln Asp Ser Glu Ser Gln Thr Leu Asp 
        195                 200                 205             


Lys Val Tyr Gln Met Lys Ser Lys Pro Arg Gly Tyr Cys Leu Ile Ile 
    210                 215                 220                 


Asn Asn His Asn Phe Ala Lys Ala Arg Glu Lys Val Pro Lys Leu His 
225                 230                 235                 240 


Ser Ile Arg Asp Arg Asn Gly Thr His Leu Asp Ala Gly Ala Leu Thr 
                245                 250                 255     


Thr Thr Phe Glu Glu Leu His Phe Glu Ile Lys Pro His Asp Asp Cys 
            260                 265                 270         


Thr Val Glu Gln Ile Tyr Glu Ile Leu Lys Ile Tyr Gln Leu Met Asp 
        275                 280                 285             


His Ser Asn Met Asp Cys Phe Ile Cys Cys Ile Leu Ser His Gly Asp 
    290                 295                 300                 


Lys Gly Ile Ile Tyr Gly Thr Asp Gly Gln Glu Ala Pro Ile Tyr Glu 
305                 310                 315                 320 


Leu Thr Ser Gln Phe Thr Gly Leu Lys Cys Pro Ser Leu Ala Gly Lys 
                325                 330                 335     


Pro Lys Val Phe Phe Ile Gln Ala Cys Gln Gly Asp Asn Tyr Gln Lys 
            340                 345                 350         


Gly Ile Pro Val Glu Thr Asp Ser Glu Glu Gln Pro Tyr Leu Glu Met 
        355                 360                 365             


Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala Asp Phe 
    370                 375                 380                 


Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg Asn Pro 
385                 390                 395                 400 


Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu Arg Glu 
                405                 410                 415     


Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu Val Asn 
            420                 425                 430         


Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys Gln Met 
        435                 440                 445             


Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


<210>  71
<211>  235
<212>  PRT
<213>  homo sapiens

<400>  71

Met Asp Phe Ser Arg Asn Leu Tyr Asp Ile Gly Glu Gln Leu Asp Ser 
1               5                   10                  15      


Glu Asp Leu Ala Ser Leu Lys Phe Leu Ser Leu Asp Tyr Ile Pro Gln 
            20                  25                  30          


Arg Lys Gln Glu Pro Ile Lys Asp Ala Leu Met Leu Phe Gln Arg Leu 
        35                  40                  45              


Gln Glu Lys Arg Met Leu Glu Glu Ser Asn Leu Ser Phe Leu Lys Glu 
    50                  55                  60                  


Leu Leu Phe Arg Ile Asn Arg Leu Asp Leu Leu Ile Thr Tyr Leu Asn 
65                  70                  75                  80  


Thr Arg Lys Glu Glu Met Glu Arg Glu Leu Gln Thr Pro Gly Arg Ala 
                85                  90                  95      


Gln Ile Ser Ala Tyr Arg Val Met Leu Tyr Gln Ile Ser Glu Glu Val 
            100                 105                 110         


Ser Arg Ser Glu Leu Arg Ser Phe Lys Phe Leu Leu Gln Glu Glu Ile 
        115                 120                 125             


Ser Lys Cys Lys Leu Asp Asp Asp Met Asn Leu Leu Asp Ile Phe Ile 
    130                 135                 140                 


Glu Met Glu Lys Arg Val Ile Leu Gly Glu Gly Lys Leu Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Val Cys Ala Gln Ile Asn Lys Ser Leu Leu Lys Ile Ile Asn 
                165                 170                 175     


Asp Tyr Glu Glu Phe Ser Lys Glu Arg Ser Ser Ser Leu Glu Gly Ser 
            180                 185                 190         


Pro Asp Glu Phe Ser Asn Asp Phe Gly Gln Ser Leu Pro Asn Glu Lys 
        195                 200                 205             


Gln Thr Ser Gly Ile Leu Ser Asp His Gln Gln Ser Gln Phe Cys Lys 
    210                 215                 220                 


Ser Thr Gly Glu Ser Ala Gln Thr Ser Gln His 
225                 230                 235 


<210>  72
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  72

Ile Leu Lys Glu Pro Val His Gly Val 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  73

Ser Leu Tyr Asn Thr Val Ala Thr Leu 
1               5                   


<210>  74
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  74

Ile Leu Glu Pro Val His Gly Val 
1               5               


<210>  75
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  75

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  76
<211>  252
<212>  PRT
<213>  Influenza A virus

<400>  76

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Val Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Arg Ala 
                85                  90                  95      


Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Val Ala Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Ala Val Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Ser Gln 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Ala Ile Gly Thr Pro Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Leu Lys Asp Asp Leu Leu Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  77
<211>  584
<212>  PRT
<213>  Influenza A virus

<400>  77

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Phe Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Met Gly Asn Thr Pro Ser Ala Lys Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Lys Pro Ala Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Ser Asn Val Ile Asn Thr Glu Thr 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Val Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Ala Asn Gly Asn Gly Phe Phe Asn Thr Met Ala Trp Val Ile Pro 
                165                 170                 175     


Lys Asp Asn Asn Lys Thr Ala Ile Asn Pro Val Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Ser Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asp Lys Thr Gln Met Glu Arg Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Glu Gly Leu Lys Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Tyr Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asn 
            420                 425                 430         


Glu Leu His Asp Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Asp Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210>  78
<211>  566
<212>  PRT
<213>  Influenza A virus

<400>  78

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
    50                  55                  60                  


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Lys Arg Arg Ser Asn 
145                 150                 155                 160 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Lys Phe Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Asn Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Thr Val Ile Pro Ser Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asp Val Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  79
<211>  466
<212>  PRT
<213>  Influenza B virus

<400>  79

Met Leu Pro Ser Thr Val Gln Thr Leu Thr Leu Leu Leu Thr Ser Gly 
1               5                   10                  15      


Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu Leu 
            20                  25                  30          


Tyr Ser Asp Val Leu Leu Lys Phe Ser Ser Thr Lys Thr Thr Ala Pro 
        35                  40                  45              


Thr Met Ser Leu Glu Cys Thr Asn Ala Ser Asn Ala Gln Thr Val Asn 
    50                  55                  60                  


His Ser Ala Thr Lys Glu Met Thr Phe Pro Pro Pro Glu Pro Glu Trp 
65                  70                  75                  80  


Thr Tyr Pro Arg Leu Ser Cys Gln Gly Ser Thr Phe Gln Lys Ala Leu 
                85                  90                  95      


Leu Ile Ser Pro His Arg Phe Gly Glu Ile Lys Gly Asn Ser Ala Pro 
            100                 105                 110         


Leu Ile Ile Arg Glu Pro Phe Val Ala Cys Gly Pro Lys Glu Cys Arg 
        115                 120                 125             


His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn 
    130                 135                 140                 


Gly Thr Arg Lys Asp Arg Asn Lys Leu Arg His Leu Val Ser Val Lys 
145                 150                 155                 160 


Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala Ala 
                165                 170                 175     


Trp Ser Gly Ser Ala Cys His Asp Gly Arg Glu Trp Thr Tyr Ile Gly 
            180                 185                 190         


Val Asp Gly Pro Asp Asn Asp Ala Leu Val Lys Ile Lys Tyr Gly Glu 
        195                 200                 205             


Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala His Asn Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asp Cys Tyr Leu Met Ile 
225                 230                 235                 240 


Thr Asp Gly Ser Ala Ser Gly Ile Ser Lys Cys Arg Phe Leu Lys Ile 
                245                 250                 255     


Arg Glu Gly Arg Ile Ile Lys Glu Ile Leu Pro Thr Gly Arg Val Glu 
            260                 265                 270         


His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu 
        275                 280                 285             


Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys 
    290                 295                 300                 


Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Lys 
305                 310                 315                 320 


Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Ala Gly Pro 
                325                 330                 335     


Cys Glu Ser Asn Gly Asp Lys Trp Leu Gly Gly Ile Lys Gly Gly Phe 
            340                 345                 350         


Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr 
        355                 360                 365             


Met Ser Lys Thr Asn Arg Met Gly Met Glu Leu Tyr Val Lys Tyr Asp 
    370                 375                 380                 


Gly Asp Pro Trp Thr Asp Ser Asp Ala Leu Thr Leu Ser Gly Val Met 
385                 390                 395                 400 


Val Ser Ile Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys 
                405                 410                 415     


Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp 
            420                 425                 430         


Gly Gly Lys Asp Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu 
        435                 440                 445             


Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asp Met 
    450                 455                 460                 


Ala Leu 
465     


<210>  80
<211>  565
<212>  PRT
<213>  Influenza C virus

<400>  80

Met Ser Asp Arg Arg Gln Asn Arg Lys Thr Pro Asp Glu Gln Arg Lys 
1               5                   10                  15      


Ala Asn Ala Leu Ile Ile Asn Glu Asn Ile Glu Ala Tyr Ile Ala Ile 
            20                  25                  30          


Cys Lys Glu Val Gly Leu Asn Gly Asp Glu Met Leu Ile Leu Glu Asn 
        35                  40                  45              


Gly Ile Ala Ile Glu Lys Ala Ile Arg Ile Cys Cys Asp Gly Lys Tyr 
    50                  55                  60                  


Gln Glu Lys Arg Glu Lys Lys Ala Arg Glu Ala Gln Arg Ala Asp Ser 
65                  70                  75                  80  


Asn Phe Asn Ala Asp Ser Ile Gly Ile Arg Leu Val Lys Arg Ala Gly 
                85                  90                  95      


Ser Gly Thr Asn Ile Thr Tyr His Ala Val Val Glu Leu Thr Ser Arg 
            100                 105                 110         


Ser Arg Ile Val Gln Ile Leu Lys Ser His Trp Gly Asn Glu Leu Asn 
        115                 120                 125             


Arg Ala Lys Ile Ala Gly Lys Arg Leu Gly Phe Ser Ala Leu Phe Ala 
    130                 135                 140                 


Ser Asn Leu Glu Ala Ile Ile Tyr Gln Arg Gly Arg Asn Ala Ala Arg 
145                 150                 155                 160 


Arg Asn Gly Ser Ala Glu Leu Phe Thr Leu Thr Gln Gly Ala Gly Ile 
                165                 170                 175     


Glu Thr Arg Tyr Lys Trp Ile Met Glu Lys His Ile Gly Ile Gly Val 
            180                 185                 190         


Leu Ile Ala Asp Ala Lys Gly Leu Ile Asn Gly Lys Arg Glu Gly Lys 
        195                 200                 205             


Arg Gly Val Asp Ala Asn Val Lys Leu Arg Ala Gly Thr Thr Gly Ser 
    210                 215                 220                 


Pro Leu Glu Arg Ala Met Gln Gly Ile Glu Lys Lys Ala Phe Pro Gly 
225                 230                 235                 240 


Pro Leu Arg Ala Leu Ala Arg Arg Val Val Lys Ala Asn Tyr Asn Asp 
                245                 250                 255     


Ala Arg Glu Ala Leu Asn Val Ile Ala Glu Ala Ser Leu Leu Leu Lys 
            260                 265                 270         


Pro Gln Ile Thr Asn Lys Met Thr Met Pro Trp Cys Met Trp Leu Ala 
        275                 280                 285             


Ala Arg Leu Thr Leu Lys Asp Glu Phe Ala Asn Phe Cys Ala Tyr Ala 
    290                 295                 300                 


Gly Arg Arg Ala Phe Glu Val Phe Asn Ile Ala Met Glu Lys Ile Gly 
305                 310                 315                 320 


Ile Cys Ser Phe Gln Gly Thr Ile Met Asn Asp Asp Glu Ile Glu Ser 
                325                 330                 335     


Ile Glu Asp Lys Ala Gln Val Leu Met Met Ala Cys Phe Gly Leu Ala 
            340                 345                 350         


Tyr Glu Asp Phe Ser Leu Val Ser Ala Met Val Ser His Pro Leu Lys 
        355                 360                 365             


Leu Arg Asn Arg Met Lys Ile Gly Asn Phe Arg Val Gly Glu Lys Val 
    370                 375                 380                 


Ser Thr Val Leu Ser Pro Leu Leu Arg Phe Thr Arg Trp Ala Glu Phe 
385                 390                 395                 400 


Ala Gln Arg Phe Ala Leu Gln Ala Asn Thr Ser Arg Glu Gly Ala Gln 
                405                 410                 415     


Ile Ser Asn Ser Ala Val Phe Ala Val Glu Arg Lys Ile Thr Thr Asp 
            420                 425                 430         


Val Gln Arg Val Glu Glu Leu Leu Asn Lys Val Gln Ala His Glu Asp 
        435                 440                 445             


Glu Pro Leu Gln Thr Leu Tyr Lys Lys Val Arg Glu Gln Ile Ser Ile 
    450                 455                 460                 


Ile Gly Arg Asn Lys Ser Glu Ile Lys Glu Phe Leu Gly Ser Ser Met 
465                 470                 475                 480 


Tyr Asp Leu Asn Asp Gln Glu Lys Gln Asn Pro Ile Asn Phe Arg Ser 
                485                 490                 495     


Gly Ala His Pro Phe Phe Phe Glu Phe Asp Pro Asp Tyr Asn Pro Ile 
            500                 505                 510         


Arg Val Lys Arg Pro Lys Lys Pro Ile Ala Lys Arg Asn Ser Asn Ile 
        515                 520                 525             


Ser Arg Leu Glu Glu Glu Gly Met Asp Glu Asn Ser Glu Ile Gly Gln 
    530                 535                 540                 


Ala Lys Lys Met Lys Pro Leu Asp Gln Leu Thr Ser Thr Ser Ser Asn 
545                 550                 555                 560 


Ile Pro Gly Lys Asn 
                565 


<210>  81
<211>  498
<212>  PRT
<213>  Influenza A virus

<400>  81

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Lys Arg Val Asp Gly Lys Trp Met Arg Glu Leu Val Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Thr Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Ile Ala Ser Gly 
        275                 280                 285             


Tyr Asn Phe Glu Lys Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Lys Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys Asn Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Ser Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Asp Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Ala Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Asp Lys Pro Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Ala Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Gly Ala Lys Pro Glu Glu Met Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  82
<211>  498
<212>  PRT
<213>  Influenza A virus

<400>  82

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met 
            20                  25                  30          


Val Gly Gly Ile Gly Arg Phe Tyr Val Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Gln Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Arg Asp Gly Lys Trp Val Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Ile Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Asp Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Arg Leu Leu Gln Asn Ser Gln Val Phe Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Arg Val 
            340                 345                 350         


Ile Pro Arg Gly Gln Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Val Glu Ala Met Asp Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Glu Arg Pro Thr Ile Met Ala Ala Phe Lys Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  83
<211>  560
<212>  PRT
<213>  Influenza B virus

<400>  83

Met Ser Asn Met Asp Ile Asp Ser Ile Asn Thr Gly Thr Ile Asp Lys 
1               5                   10                  15      


Thr Pro Glu Glu Leu Thr Pro Gly Thr Ser Gly Ala Thr Arg Pro Ile 
            20                  25                  30          


Ile Lys Pro Ala Thr Leu Ala Pro Pro Ser Asn Lys Arg Thr Arg Asn 
        35                  40                  45              


Pro Ser Pro Glu Arg Thr Thr Thr Ser Ser Glu Thr Asp Ile Gly Arg 
    50                  55                  60                  


Lys Ile Gln Lys Lys Gln Thr Pro Thr Glu Ile Lys Lys Ser Val Tyr 
65                  70                  75                  80  


Lys Met Val Val Lys Leu Gly Glu Phe Tyr Asn Gln Met Met Val Lys 
                85                  90                  95      


Ala Gly Leu Asn Asp Asp Met Glu Arg Asn Leu Ile Gln Asn Ala Gln 
            100                 105                 110         


Ala Val Glu Arg Ile Leu Leu Ala Ala Thr Asp Asp Lys Lys Thr Glu 
        115                 120                 125             


Tyr Gln Lys Lys Arg Asn Ala Arg Asp Val Lys Glu Gly Lys Glu Glu 
    130                 135                 140                 


Ile Asp His Asn Lys Thr Gly Gly Thr Phe Tyr Lys Met Val Arg Asp 
145                 150                 155                 160 


Asp Lys Thr Ile Tyr Phe Ser Pro Ile Lys Ile Thr Phe Leu Lys Glu 
                165                 170                 175     


Glu Val Lys Thr Met Tyr Lys Thr Thr Met Gly Ser Asp Gly Phe Ser 
            180                 185                 190         


Gly Leu Asn His Ile Met Ile Gly His Ser Gln Met Asn Asp Val Cys 
        195                 200                 205             


Phe Gln Arg Ser Lys Gly Leu Lys Arg Val Gly Leu Asp Pro Ser Leu 
    210                 215                 220                 


Ile Ser Thr Phe Ala Gly Ser Thr Leu Pro Arg Arg Ser Gly Thr Thr 
225                 230                 235                 240 


Gly Val Ala Ile Lys Gly Gly Gly Thr Leu Val Asp Glu Ala Ile Arg 
                245                 250                 255     


Phe Ile Gly Arg Ala Met Ala Asp Arg Gly Leu Leu Arg Asp Ile Lys 
            260                 265                 270         


Ala Lys Thr Ala Tyr Glu Lys Ile Leu Leu Asn Leu Lys Asn Lys Cys 
        275                 280                 285             


Ser Ala Pro Gln Gln Lys Ala Leu Val Asp Gln Val Ile Gly Ser Arg 
    290                 295                 300                 


Asn Pro Gly Ile Ala Asp Ile Glu Asp Leu Thr Leu Leu Ala Arg Ser 
305                 310                 315                 320 


Met Val Val Val Arg Pro Ser Val Ala Ser Lys Val Val Leu Pro Ile 
                325                 330                 335     


Ser Ile Tyr Ala Lys Ile Pro Gln Leu Gly Phe Asn Thr Glu Glu Tyr 
            340                 345                 350         


Ser Met Val Gly Tyr Glu Ala Met Ala Leu Tyr Asn Met Ala Thr Pro 
        355                 360                 365             


Val Ser Ile Leu Arg Met Gly Asp Asp Ala Lys Asp Lys Ser Gln Leu 
    370                 375                 380                 


Phe Phe Met Ser Cys Phe Gly Ala Ala Tyr Glu Asp Leu Arg Val Leu 
385                 390                 395                 400 


Ser Ala Leu Thr Gly Thr Glu Phe Lys Pro Arg Ser Ala Leu Lys Cys 
                405                 410                 415     


Lys Gly Phe His Val Pro Ala Lys Glu Gln Val Glu Gly Met Gly Ala 
            420                 425                 430         


Ala Leu Met Ser Ile Lys Leu Gln Phe Trp Ala Pro Met Thr Arg Ser 
        435                 440                 445             


Gly Gly Asn Glu Val Ser Gly Glu Gly Gly Ser Gly Gln Ile Ser Cys 
    450                 455                 460                 


Ser Pro Val Phe Ala Val Glu Arg Pro Ile Ala Leu Ser Lys Gln Ala 
465                 470                 475                 480 


Val Arg Arg Met Leu Ser Met Asn Val Glu Gly Arg Asp Ala Asp Val 
                485                 490                 495     


Lys Gly Asn Leu Leu Lys Met Met Asn Asp Ser Met Ala Lys Lys Thr 
            500                 505                 510         


Ser Gly Asn Ala Phe Ile Gly Lys Lys Met Phe Gln Ile Ser Asp Lys 
        515                 520                 525             


Asn Lys Val Asn Pro Ile Glu Ile Pro Ile Lys Gln Thr Ile Pro Asn 
    530                 535                 540                 


Phe Phe Phe Gly Arg Asp Thr Ala Glu Asp Tyr Asp Asp Leu Asp Tyr 
545                 550                 555                 560 


<210>  84
<211>  248
<212>  PRT
<213>  Influenza B virus

<400>  84

Met Ser Leu Phe Gly Asp Thr Ile Ala Tyr Leu Leu Ser Leu Ile Glu 
1               5                   10                  15      


Asp Gly Glu Gly Lys Ala Glu Leu Ala Glu Lys Leu His Cys Trp Phe 
            20                  25                  30          


Gly Gly Lys Glu Phe Asp Leu Asp Ser Ala Leu Glu Trp Ile Lys Asn 
        35                  40                  45              


Lys Arg Cys Leu Thr Asp Ile Gln Lys Ala Leu Ile Gly Ala Ser Ile 
    50                  55                  60                  


Cys Phe Leu Lys Pro Lys Asp Gln Glu Arg Lys Arg Arg Phe Ile Thr 
65                  70                  75                  80  


Glu Pro Leu Ser Gly Met Gly Thr Thr Ala Thr Lys Lys Lys Gly Leu 
                85                  90                  95      


Ile Leu Ala Glu Arg Lys Met Arg Arg Cys Val Ser Phe His Glu Ala 
            100                 105                 110         


Phe Glu Ile Ala Glu Gly His Glu Ser Ser Ala Leu Leu Tyr Cys Leu 
        115                 120                 125             


Met Val Met Tyr Leu Asn Pro Glu Asn Tyr Ser Met Gln Val Lys Leu 
    130                 135                 140                 


Gly Thr Leu Cys Ala Leu Cys Glu Lys Gln Ala Ser His Ser His Arg 
145                 150                 155                 160 


Ala His Ser Arg Ala Ala Arg Ser Ser Val Pro Gly Val Arg Arg Glu 
                165                 170                 175     


Met Gln Met Val Ser Ala Met Asn Thr Ala Lys Thr Met Asn Gly Met 
            180                 185                 190         


Gly Lys Gly Glu Asp Val Gln Lys Leu Ala Glu Glu Leu Gln Asn Asn 
        195                 200                 205             


Ile Gly Val Leu Arg Ser Leu Gly Ala Ser Gln Lys Asn Gly Glu Gly 
    210                 215                 220                 


Ile Ala Lys Asp Val Met Glu Val Leu Lys Gln Ser Ser Met Gly Asn 
225                 230                 235                 240 


Ser Ala Leu Val Arg Lys Tyr Leu 
                245             


<210>  85
<211>  97
<212>  PRT
<213>  Influenza A virus

<400>  85

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Gly Ser Ser Asp Pro Leu Ala Ile Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Ile Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Phe Lys Tyr Gly Leu Lys Gly Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Lys Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln 
65                  70                  75                  80  


Gln Ser Ala Val Asp Ala Asp Asp Gly His Phe Val Ser Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210>  86
<211>  281
<212>  PRT
<213>  Influenza B virus

<400>  86

Met Ala Asp Asn Met Thr Thr Thr Gln Ile Glu Val Gly Pro Gly Ala 
1               5                   10                  15      


Thr Asn Ala Thr Ile Asn Phe Glu Ala Gly Ile Leu Glu Cys Tyr Glu 
            20                  25                  30          


Arg Phe Ser Trp Gln Arg Ala Leu Asp Tyr Pro Gly Gln Asp Arg Leu 
        35                  40                  45              


His Arg Leu Lys Arg Lys Leu Glu Ser Arg Ile Lys Thr His Asn Lys 
    50                  55                  60                  


Ser Glu Pro Glu Asn Lys Arg Met Ser Leu Glu Glu Arg Lys Ala Ile 
65                  70                  75                  80  


Gly Val Lys Met Met Lys Val Leu Leu Phe Met Asp Pro Ser Ala Gly 
                85                  90                  95      


Ile Glu Gly Phe Glu Pro Tyr Cys Val Lys Asn Pro Ser Thr Ser Lys 
            100                 105                 110         


Cys Pro Asn Tyr Asp Trp Thr Asp Tyr Pro Pro Thr Pro Gly Lys Tyr 
        115                 120                 125             


Leu Asp Asp Ile Glu Glu Glu Pro Glu Asn Val Asp His Pro Ile Glu 
    130                 135                 140                 


Val Val Leu Arg Asp Met Asn Asn Lys Asp Ala Arg Gln Lys Ile Lys 
145                 150                 155                 160 


Asp Glu Val Asn Thr Gln Lys Glu Gly Lys Phe Arg Leu Thr Ile Lys 
                165                 170                 175     


Arg Asp Ile Arg Asn Val Leu Ser Leu Arg Val Leu Val Asn Gly Thr 
            180                 185                 190         


Phe Leu Lys His Pro Asn Gly Asp Lys Ser Leu Ser Thr Leu His Arg 
        195                 200                 205             


Leu Asn Ala Tyr Asp Gln Asn Gly Gly Leu Val Ala Lys Leu Val Ala 
    210                 215                 220                 


Thr Asp Asp Arg Thr Val Glu Asp Glu Lys Asp Gly His Arg Ile Leu 
225                 230                 235                 240 


Asn Ser Leu Phe Glu Arg Phe Asp Glu Gly His Ser Lys Pro Ile Arg 
                245                 250                 255     


Ala Ala Glu Thr Ala Val Gly Val Leu Ser Gln Phe Gly Gln Glu His 
            260                 265                 270         


Arg Leu Ser Pro Glu Glu Gly Asp Asn 
        275                 280     


<210>  87
<211>  122
<212>  PRT
<213>  Influenza B virus

<400>  87

Met Ala Asp Asn Met Thr Thr Thr Gln Ile Glu Trp Arg Met Lys Lys 
1               5                   10                  15      


Met Ala Ile Gly Ser Ser Thr His Ser Ser Ser Val Leu Met Lys Asp 
            20                  25                  30          


Ile Gln Ser Gln Phe Glu Gln Leu Lys Leu Arg Trp Glu Ser Tyr Pro 
        35                  40                  45              


Asn Leu Val Lys Ser Thr Asp Tyr His Gln Lys Arg Glu Thr Ile Arg 
    50                  55                  60                  


Leu Ala Thr Glu Glu Leu Tyr Leu Leu Ser Lys Arg Ile Asp Asp Ser 
65                  70                  75                  80  


Ile Leu Phe His Lys Thr Val Ile Ala Asn Ser Ser Ile Ile Ala Asp 
                85                  90                  95      


Met Ile Val Ser Leu Ser Leu Leu Glu Thr Leu Tyr Glu Met Lys Asp 
            100                 105                 110         


Val Val Glu Val Tyr Ser Arg Gln Cys Leu 
        115                 120         


<210>  88
<211>  716
<212>  PRT
<213>  Influenza A virus

<400>  88

Met Glu Asp Phe Val Arg Gln Cys Phe Asn Pro Met Ile Val Glu Leu 
1               5                   10                  15      


Ala Glu Lys Ala Met Lys Glu Tyr Gly Glu Asp Leu Lys Ile Glu Thr 
            20                  25                  30          


Asn Lys Phe Ala Ala Ile Cys Thr His Leu Glu Val Cys Phe Met Tyr 
        35                  40                  45              


Ser Asp Phe His Phe Ile Asn Glu Gln Gly Glu Ser Ile Ile Val Glu 
    50                  55                  60                  


Pro Glu Asp Pro Asn Ala Leu Leu Lys His Arg Phe Glu Ile Ile Glu 
65                  70                  75                  80  


Gly Arg Asp Arg Thr Met Ala Trp Thr Val Val Asn Ser Ile Cys Asn 
                85                  90                  95      


Thr Thr Gly Ala Glu Lys Pro Lys Phe Leu Pro Asp Leu Tyr Asp Tyr 
            100                 105                 110         


Lys Glu Asn Arg Phe Ile Glu Ile Gly Val Thr Arg Arg Glu Val His 
        115                 120                 125             


Ile Tyr Tyr Leu Glu Lys Ala Asn Lys Ile Lys Ser Glu Lys Thr His 
    130                 135                 140                 


Ile His Ile Phe Ser Phe Thr Gly Glu Glu Met Ala Thr Lys Ala Asp 
145                 150                 155                 160 


Tyr Thr Leu Asp Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe 
                165                 170                 175     


Thr Ile Arg Gln Glu Met Ala Ser Arg Gly Leu Trp Asp Ser Phe Arg 
            180                 185                 190         


Gln Ser Glu Arg Gly Glu Glu Thr Ile Glu Glu Arg Phe Glu Ile Thr 
        195                 200                 205             


Gly Thr Met Arg Arg Leu Ala Asp Gln Ser Leu Pro Pro Asn Phe Ser 
    210                 215                 220                 


Cys Leu Glu Asn Phe Arg Ala Tyr Val Asp Gly Phe Glu Pro Asn Gly 
225                 230                 235                 240 


Tyr Ile Glu Gly Lys Leu Ser Gln Met Ser Lys Glu Val Asn Ala Arg 
                245                 250                 255     


Ile Glu Pro Phe Leu Arg Thr Thr Pro Arg Pro Ile Arg Leu Pro Asp 
            260                 265                 270         


Gly Pro Pro Cys Phe Gln Arg Ser Lys Phe Leu Leu Met Asp Ser Leu 
        275                 280                 285             


Lys Leu Ser Ile Glu Asp Pro Ser His Glu Gly Glu Gly Ile Pro Leu 
    290                 295                 300                 


Tyr Asp Ala Ile Lys Cys Met Arg Thr Phe Phe Gly Trp Lys Glu Pro 
305                 310                 315                 320 


Ser Val Val Lys Pro His Gly Lys Gly Ile Asn Pro Asn Tyr Leu Leu 
                325                 330                 335     


Ser Trp Lys Gln Val Leu Ala Glu Leu Gln Asp Ile Glu Ser Glu Glu 
            340                 345                 350         


Lys Ile Pro Arg Thr Lys Asn Met Lys Lys Thr Ser Gln Leu Lys Trp 
        355                 360                 365             


Ala Leu Gly Glu Asn Met Ala Pro Glu Lys Val Asp Phe Asp Asp Cys 
    370                 375                 380                 


Lys Asp Ile Ser Asp Leu Lys Gln Tyr Asp Ser Asp Glu Pro Glu Leu 
385                 390                 395                 400 


Arg Ser Leu Ser Ser Trp Ile Gln Asn Glu Phe Asn Lys Ala Cys Glu 
                405                 410                 415     


Leu Thr Asp Ser Ile Trp Ile Glu Leu Asp Glu Ile Gly Glu Asp Val 
            420                 425                 430         


Ala Pro Ile Glu His Ile Ala Ser Met Arg Arg Asn Tyr Phe Thr Ala 
        435                 440                 445             


Glu Val Ser His Cys Arg Ala Thr Glu Tyr Ile Met Lys Gly Val Tyr 
    450                 455                 460                 


Ile Asn Thr Ala Leu Leu Asn Ala Ser Cys Ala Ala Met Asp Asp Phe 
465                 470                 475                 480 


Gln Leu Ile Pro Met Ile Ser Lys Cys Arg Thr Lys Glu Gly Arg Arg 
                485                 490                 495     


Lys Thr Asn Leu Tyr Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg 
            500                 505                 510         


Asn Asp Thr Asp Val Val Asn Phe Val Ser Met Glu Phe Ser Leu Thr 
        515                 520                 525             


Asp Pro Arg Leu Glu Pro His Lys Trp Glu Lys Tyr Cys Val Leu Glu 
    530                 535                 540                 


Ile Gly Asp Met Leu Leu Arg Ser Ala Ile Gly Gln Val Ser Arg Pro 
545                 550                 555                 560 


Met Phe Leu Tyr Val Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys 
                565                 570                 575     


Trp Gly Met Glu Met Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Ile 
            580                 585                 590         


Glu Ser Met Ile Glu Ala Glu Ser Ser Val Lys Glu Lys Asp Met Thr 
        595                 600                 605             


Lys Glu Phe Phe Glu Asn Arg Ser Glu Thr Trp Pro Ile Gly Glu Ser 
    610                 615                 620                 


Pro Lys Gly Val Glu Glu Gly Ser Ile Gly Lys Val Cys Arg Thr Leu 
625                 630                 635                 640 


Leu Ala Lys Ser Val Phe Asn Ser Leu Tyr Ala Ser Pro Gln Leu Glu 
                645                 650                 655     


Gly Phe Ser Ala Glu Ser Arg Lys Leu Leu Leu Ile Val Gln Ala Leu 
            660                 665                 670         


Arg Asp Asn Leu Glu Pro Gly Thr Phe Asp Leu Gly Gly Leu Tyr Glu 
        675                 680                 685             


Ala Ile Glu Glu Cys Leu Ile Asn Asp Pro Trp Val Leu Leu Asn Ala 
    690                 695                 700                 


Ser Trp Phe Asn Ser Phe Leu Thr His Ala Leu Arg 
705                 710                 715     


<210>  89
<211>  752
<212>  PRT
<213>  Influenza B virus

<400>  89

Met Asn Ile Asn Pro Tyr Phe Leu Phe Ile Asp Val Pro Ile Gln Ala 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Val Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Ile Asp Thr Val Ile Arg Thr His Glu 
        35                  40                  45              


Tyr Ser Asn Lys Gly Lys Gln Tyr Ile Ser Asp Val Thr Gly Cys Val 
    50                  55                  60                  


Met Val Asp Pro Thr Asn Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Ala Tyr Ala Gln Leu Asp Cys Val Leu Glu Ala Leu Asp Arg Met Asp 
                85                  90                  95      


Glu Glu His Pro Gly Leu Phe Gln Ala Gly Ser Gln Asn Ala Met Glu 
            100                 105                 110         


Ala Leu Met Val Thr Thr Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Phe Asp Trp Thr Val Cys Arg Asn Gln Pro Ala Ala Thr Ala Leu Asn 
    130                 135                 140                 


Thr Thr Ile Thr Ser Phe Arg Leu Asn Asp Leu Asn Gly Ala Asp Lys 
145                 150                 155                 160 


Gly Gly Leu Val Pro Phe Cys Gln Asp Ile Ile Asp Ser Leu Asp Lys 
                165                 170                 175     


Pro Glu Met Ile Phe Phe Thr Val Lys Asn Ile Lys Lys Lys Leu Pro 
            180                 185                 190         


Ala Lys Asn Arg Lys Gly Phe Leu Ile Lys Arg Ile Pro Met Lys Val 
        195                 200                 205             


Lys Asp Arg Ile Thr Arg Val Glu Tyr Ile Lys Arg Ala Leu Ser Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Ala Gly Ile Gln Ile Arg Gly Phe Val Leu Val Val Glu 
                245                 250                 255     


Asn Leu Ala Lys Asn Ile Cys Glu Asn Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ser Asn Ala Val Ala Lys 
        275                 280                 285             


Met Leu Ser Asn Cys Pro Pro Gly Gly Ile Ser Met Thr Val Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Cys Leu Asn Pro Arg Ile Phe Leu Ala 
305                 310                 315                 320 


Met Thr Glu Arg Ile Thr Arg Asp Ser Pro Ile Trp Phe Arg Asp Phe 
                325                 330                 335     


Cys Ser Ile Ala Pro Val Leu Phe Ser Asn Lys Ile Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Phe Met Ile Thr Ser Lys Thr Lys Arg Leu Lys Ala Gln Ile 
        355                 360                 365             


Pro Cys Pro Asp Leu Phe Asn Ile Pro Leu Glu Arg Tyr Asn Glu Glu 
    370                 375                 380                 


Thr Arg Ala Lys Leu Lys Lys Leu Lys Pro Phe Phe Asn Glu Glu Gly 
385                 390                 395                 400 


Thr Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu 
                405                 410                 415     


Ser Thr Val Leu Gly Val Ala Ala Leu Gly Ile Lys Asn Ile Gly Asn 
            420                 425                 430         


Lys Glu Tyr Leu Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala Leu 
        435                 440                 445             


Phe Val Asn Ala Lys Asp Glu Glu Thr Cys Met Glu Gly Ile Asn Asp 
    450                 455                 460                 


Phe Tyr Arg Thr Cys Lys Leu Leu Gly Ile Asn Met Ser Lys Lys Lys 
465                 470                 475                 480 


Ser Tyr Cys Asn Glu Thr Gly Met Phe Glu Phe Thr Ser Met Phe Tyr 
                485                 490                 495     


Arg Asp Gly Phe Val Ser Asn Phe Ala Met Glu Leu Pro Ser Phe Gly 
            500                 505                 510         


Val Ala Gly Val Asn Glu Ser Ala Asp Met Ala Ile Gly Met Thr Ile 
        515                 520                 525             


Ile Lys Asn Asn Met Ile Asn Asn Gly Met Gly Pro Ala Thr Ala Gln 
    530                 535                 540                 


Thr Ala Ile Gln Leu Phe Ile Ala Asp Tyr Arg Tyr Thr Tyr Lys Cys 
545                 550                 555                 560 


His Arg Gly Asp Ser Lys Val Glu Gly Lys Arg Met Lys Ile Ile Lys 
                565                 570                 575     


Glu Leu Trp Glu Asn Thr Lys Gly Arg Asp Gly Leu Leu Val Ala Asp 
            580                 585                 590         


Gly Gly Pro Asn Leu Tyr Asn Leu Arg Asn Leu His Ile Pro Glu Ile 
        595                 600                 605             


Ile Leu Lys Tyr Asn Ile Met Asp Pro Glu Tyr Lys Gly Arg Leu Leu 
    610                 615                 620                 


His Pro Gln Asn Pro Phe Val Gly His Leu Ser Ile Glu Gly Ile Lys 
625                 630                 635                 640 


Glu Ala Asp Ile Thr Pro Ala His Gly Pro Ile Lys Lys Met Asp Tyr 
                645                 650                 655     


Asp Ala Val Ser Gly Thr His Ser Trp Arg Thr Lys Arg Asn Arg Ser 
            660                 665                 670         


Ile Leu Asn Thr Asp Gln Arg Asn Met Ile Leu Glu Glu Gln Cys Tyr 
        675                 680                 685             


Ala Lys Cys Cys Asn Leu Phe Glu Ala Cys Phe Asn Ser Ala Ser Tyr 
    690                 695                 700                 


Arg Lys Pro Val Gly Gln His Ser Met Leu Glu Ala Met Ala His Arg 
705                 710                 715                 720 


Leu Arg Met Asp Ala Arg Leu Asp Tyr Glu Ser Gly Arg Met Ser Lys 
                725                 730                 735     


Glu Asp Phe Glu Lys Ala Met Ala His Leu Gly Glu Ile Gly Tyr Met 
            740                 745                 750         


<210>  90
<211>  759
<212>  PRT
<213>  Influenza A virus

<400>  90

Met Glu Arg Ile Lys Glu Leu Arg Asn Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Thr 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Met Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Met Thr Asn Thr Val His Tyr Pro 
            100                 105                 110         


Lys Ile Tyr Lys Thr Tyr Phe Glu Arg Val Glu Arg Leu Lys His Gly 
        115                 120                 125             


Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 


Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 


Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     


Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         


Leu Gln Asp Cys Lys Ile Ser Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             


Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 


Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 


Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Lys Asn Asp Asp Val Asp 
                245                 250                 255     


Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Ala Val 
            260                 265                 270         


Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             


Ile Gly Gly Ile Arg Met Val Asp Ile Leu Lys Gln Asn Pro Thr Glu 
    290                 295                 300                 


Glu Gln Ala Val Gly Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 


Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     


Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         


Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             


Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 


Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 


Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     


Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         


Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             


Trp Gly Val Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 


Pro Asp Met Thr Pro Ser Ile Glu Met Ser Met Arg Gly Val Arg Ile 
465                 470                 475                 480 


Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 
                485                 490                 495     


Ser Ile Asp Arg Phe Leu Arg Val Arg Asp Gln Arg Gly Asn Val Leu 
            500                 505                 510         


Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             


Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 


Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Val 
545                 550                 555                 560 


Lys Ile Gln Trp Ser Gln Asn Pro Thr Met Leu Tyr Asn Lys Met Glu 
                565                 570                 575     


Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Ile Arg Gly Gln Tyr 
            580                 585                 590         


Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             


Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 


Pro Pro Lys Gln Ser Arg Met Gln Phe Ser Ser Phe Thr Val Asn Val 
625                 630                 635                 640 


Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     


Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         


Gly Thr Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             


Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Arg Arg Tyr 
    690                 695                 700                 


Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 
705                 710                 715                 720 


Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     


Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         


Arg Ile Arg Met Ala Ile Asn 
        755                 


<210>  91
<211>  109
<212>  PRT
<213>  Influenza B virus

<400>  91

Met Leu Glu Pro Leu Gln Ile Leu Ser Ile Cys Ser Phe Ile Leu Ser 
1               5                   10                  15      


Ala Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln Ile Lys 
            20                  25                  30          


Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys Glu Ala 
        35                  40                  45              


Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
            100                 105                 


<210>  92
<211>  100
<212>  PRT
<213>  Influenza B virus

<400>  92

Met Asn Asn Ala Thr Phe Asn Cys Thr Asn Ile Asn Pro Ile Thr His 
1               5                   10                  15      


Ile Arg Gly Ser Ile Ile Ile Thr Ile Cys Val Ser Leu Ile Val Ile 
            20                  25                  30          


Leu Ile Val Phe Gly Cys Ile Ala Lys Ile Phe Ile Asn Lys Asn Asn 
        35                  40                  45              


Cys Thr Asn Asn Val Ile Arg Val His Lys Arg Ile Lys Cys Pro Asp 
    50                  55                  60                  


Cys Glu Pro Phe Cys Asn Lys Arg Asp Asp Ile Ser Thr Pro Arg Ala 
65                  70                  75                  80  


Gly Val Asp Ile Pro Ser Phe Ile Leu Pro Gly Leu Asn Leu Ser Glu 
                85                  90                  95      


Gly Thr Pro Asn 
            100 


<210>  93
<211>  498
<212>  PRT
<213>  Influenza A virus

<400>  93

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Val Asn Gly Lys Trp Met Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Val Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Lys Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asp Pro Gly Asn Ala Glu Phe Glu Asp Leu 
                245                 250                 255     


Thr Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Arg Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Lys Gly Thr Lys Val 
            340                 345                 350         


Val Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Glu Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Asp Arg Thr Thr Val Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Ala Ser Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  94
<211>  548
<212>  PRT
<213>  Human herpesvirus 5

<400>  94

Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly 
1               5                   10                  15      


Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr 
            20                  25                  30          


Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val 
        35                  40                  45              


Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp 
    50                  55                  60                  


Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr 
65                  70                  75                  80  


Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Glu Pro Met 
                85                  90                  95      


Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser 
            100                 105                 110         


Ile Asn Val His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His 
        115                 120                 125             


Leu Pro Val Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp 
    130                 135                 140                 


Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn 
145                 150                 155                 160 


Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro 
                165                 170                 175     


Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val 
            180                 185                 190         


Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp 
        195                 200                 205             


Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser 
    210                 215                 220                 


Gly Lys Leu Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp 
225                 230                 235                 240 


Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg 
                245                 250                 255     


Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly 
            260                 265                 270         


Lys Ile Ser His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His 
        275                 280                 285             


Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly 
    290                 295                 300                 


Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile 
305                 310                 315                 320 


Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe 
                325                 330                 335     


Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu 
            340                 345                 350         


His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr 
        355                 360                 365             


Arg His Thr Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp 
    370                 375                 380                 


Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr 
385                 390                 395                 400 


Glu Arg Lys Thr Pro Arg Val Thr Gly Gly Gly Ala Met Ala Gly Ala 
                405                 410                 415     


Ser Thr Ser Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser Ala Thr Ala 
            420                 425                 430         


Cys Thr Ser Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr 
        435                 440                 445             


Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His 
    450                 455                 460                 


Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala 
465                 470                 475                 480 


Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys 
                485                 490                 495     


Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala 
            500                 505                 510         


Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gln Pro Lys Arg Arg Arg 
        515                 520                 525             


His Arg Gln Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser Thr Pro Lys 
    530                 535                 540                 


Lys His Arg Gly 
545             


<210>  95
<211>  561
<212>  PRT
<213>  Human herpesvirus 5

<400>  95

Met Glu Ser Arg Gly Arg Arg Cys Pro Glu Met Ile Ser Val Leu Gly 
1               5                   10                  15      


Pro Ile Ser Gly His Val Leu Lys Ala Val Phe Ser Arg Gly Asp Thr 
            20                  25                  30          


Pro Val Leu Pro His Glu Thr Arg Leu Leu Gln Thr Gly Ile His Val 
        35                  40                  45              


Arg Val Ser Gln Pro Ser Leu Ile Leu Val Ser Gln Tyr Thr Pro Asp 
    50                  55                  60                  


Ser Thr Pro Cys His Arg Gly Asp Asn Gln Leu Gln Val Gln His Thr 
65                  70                  75                  80  


Tyr Phe Thr Gly Ser Glu Val Glu Asn Val Ser Val Asn Val His Asn 
                85                  90                  95      


Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln Glu Pro Met Ser Ile Tyr 
            100                 105                 110         


Val Tyr Ala Leu Pro Leu Lys Met Leu Asn Ile Pro Ser Ile Asn Val 
        115                 120                 125             


His His Tyr Pro Ser Ala Ala Glu Arg Lys His Arg His Leu Pro Val 
    130                 135                 140                 


Ala Asp Ala Val Ile His Ala Ser Gly Lys Gln Met Trp Gln Ala Arg 
145                 150                 155                 160 


Leu Thr Val Ser Gly Leu Ala Trp Thr Arg Gln Gln Asn Gln Trp Lys 
                165                 170                 175     


Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe Val Phe Pro Thr Lys Asp 
            180                 185                 190         


Val Ala Leu Arg His Val Val Cys Ala His Glu Leu Val Cys Ser Met 
        195                 200                 205             


Glu Asn Thr Arg Ala Thr Lys Met Gln Val Ile Gly Asp Gln Tyr Val 
    210                 215                 220                 


Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp Val Pro Ser Gly Lys Leu 
225                 230                 235                 240 


Phe Met His Val Thr Leu Gly Ser Asp Val Glu Glu Asp Leu Thr Met 
                245                 250                 255     


Thr Arg Asn Pro Gln Pro Phe Met Arg Pro His Glu Arg Asn Gly Phe 
            260                 265                 270         


Thr Val Leu Cys Pro Lys Asn Met Ile Ile Lys Pro Gly Lys Ile Ser 
        275                 280                 285             


His Ile Met Leu Asp Val Ala Phe Thr Ser His Glu His Phe Gly Leu 
    290                 295                 300                 


Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser Ile Ser Gly Asn Leu Leu 
305                 310                 315                 320 


Met Asn Gly Gln Gln Ile Phe Leu Glu Val Gln Ala Ile Arg Glu Thr 
                325                 330                 335     


Val Glu Leu Arg Gln Tyr Asp Pro Val Ala Ala Leu Phe Phe Phe Asp 
            340                 345                 350         


Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln Tyr Ser Glu His Pro Thr 
        355                 360                 365             


Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys Leu Glu Tyr Arg His Thr 
    370                 375                 380                 


Trp Asp Arg His Asp Glu Gly Ala Ala Gln Gly Asp Asp Asp Val Trp 
385                 390                 395                 400 


Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu Val Thr Thr Glu Arg Lys 
                405                 410                 415     


Thr Pro Arg Val Thr Gly Gly Gly Ala Met Ala Gly Ala Ser Thr Ser 
            420                 425                 430         


Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser Ala Thr Ala Cys Thr Ser 
        435                 440                 445             


Gly Val Met Thr Arg Gly Arg Leu Lys Ala Glu Ser Thr Val Ala Pro 
    450                 455                 460                 


Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn Glu Ile His Asn Pro Ala 
465                 470                 475                 480 


Val Phe Thr Trp Pro Pro Trp Gln Ala Gly Ile Leu Ala Arg Asn Leu 
                485                 490                 495     


Val Pro Met Val Ala Thr Val Gln Gly Gln Asn Leu Lys Tyr Gln Glu 
            500                 505                 510         


Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg Ile Phe Ala Glu Leu Glu 
        515                 520                 525             


Gly Val Trp Gln Pro Ala Ala Gln Pro Lys Arg Arg Arg His Arg Gln 
    530                 535                 540                 


Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser Thr Pro Lys Lys His Arg 
545                 550                 555                 560 


Gly 
    


<210>  96
<211>  551
<212>  PRT
<213>  Human herpesvirus 5

<400>  96

Met Ala Ser Val Leu Gly Pro Ile Ser Gly His Val Leu Lys Ala Val 
1               5                   10                  15      


Phe Ser Arg Gly Asp Thr Pro Val Leu Pro His Glu Thr Arg Leu Leu 
            20                  25                  30          


Gln Thr Gly Ile His Val Arg Val Ser Gln Pro Ser Leu Ile Leu Val 
        35                  40                  45              


Ser Gln Tyr Thr Pro Asp Ser Thr Pro Cys His Arg Gly Asp Asn Gln 
    50                  55                  60                  


Leu Gln Val Gln His Thr Tyr Phe Thr Gly Ser Glu Val Glu Asn Val 
65                  70                  75                  80  


Ser Val Asn Val His Asn Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln 
                85                  90                  95      


Glu Pro Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn 
            100                 105                 110         


Ile Pro Ser Ile Asn Val His His Tyr Pro Ser Ala Ala Glu Arg Lys 
        115                 120                 125             


His Arg His Leu Pro Val Ala Asp Ala Val Ile His Ala Ser Gly Lys 
    130                 135                 140                 


Gln Met Trp Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp Thr Arg 
145                 150                 155                 160 


Gln Gln Asn Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe 
                165                 170                 175     


Val Phe Pro Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala His 
            180                 185                 190         


Glu Leu Val Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val 
        195                 200                 205             


Ile Gly Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp 
    210                 215                 220                 


Val Pro Ser Gly Lys Leu Phe Met His Val Thr Leu Gly Ser Asp Val 
225                 230                 235                 240 


Glu Glu Asp Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met Arg Pro 
                245                 250                 255     


His Glu Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile 
            260                 265                 270         


Lys Pro Gly Lys Ile Ser His Ile Met Leu Asp Val Ala Phe Thr Ser 
        275                 280                 285             


His Glu His Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser 
    290                 295                 300                 


Ile Ser Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val 
305                 310                 315                 320 


Gln Ala Ile Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro Val Ala 
                325                 330                 335     


Ala Leu Phe Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln 
            340                 345                 350         


Tyr Ser Glu His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys 
        355                 360                 365             


Leu Glu Tyr Arg His Thr Trp Asp Arg His Asp Glu Gly Ala Ala Gln 
    370                 375                 380                 


Gly Asp Asp Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu 
385                 390                 395                 400 


Val Thr Thr Glu Arg Lys Thr Pro Arg Val Thr Gly Gly Gly Ala Met 
                405                 410                 415     


Ala Gly Ala Ser Thr Ser Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser 
            420                 425                 430         


Ala Thr Ala Cys Thr Ala Gly Val Met Thr Arg Gly Arg Leu Lys Ala 
        435                 440                 445             


Glu Ser Thr Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn 
    450                 455                 460                 


Glu Ile His Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln Ala Gly 
465                 470                 475                 480 


Ile Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln 
                485                 490                 495     


Asn Leu Lys Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg 
            500                 505                 510         


Ile Phe Ala Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gln Pro Lys 
        515                 520                 525             


Arg Arg Arg His Arg Gln Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser 
    530                 535                 540                 


Thr Pro Lys Lys His Arg Gly 
545                 550     


<210>  97
<211>  551
<212>  PRT
<213>  Human herpesvirus 5

<400>  97

Met Ala Ser Val Leu Gly Pro Ile Ser Gly His Val Leu Lys Ala Val 
1               5                   10                  15      


Phe Ser Arg Gly Asp Thr Pro Val Leu Pro His Glu Thr Arg Leu Leu 
            20                  25                  30          


Gln Thr Gly Ile His Val Arg Val Ser Gln Pro Ser Leu Ile Leu Val 
        35                  40                  45              


Ser Gln Tyr Thr Pro Asp Ser Thr Pro Cys His Arg Gly Asp Asn Gln 
    50                  55                  60                  


Leu Gln Val Gln His Thr Tyr Phe Thr Gly Ser Glu Val Glu Asn Val 
65                  70                  75                  80  


Ser Val Asn Val His Asn Pro Thr Gly Arg Ser Ile Cys Pro Ser Gln 
                85                  90                  95      


Glu Pro Met Ser Ile Tyr Val Tyr Ala Leu Pro Leu Lys Met Leu Asn 
            100                 105                 110         


Ile Pro Ser Ile Asn Val His His Tyr Pro Ser Ala Ala Glu Arg Lys 
        115                 120                 125             


His Arg His Leu Pro Val Ala Asp Ala Val Ile His Ala Ser Gly Lys 
    130                 135                 140                 


Gln Met Trp Gln Ala Arg Leu Thr Val Ser Gly Leu Ala Trp Thr Arg 
145                 150                 155                 160 


Gln Gln Asn Gln Trp Lys Glu Pro Asp Val Tyr Tyr Thr Ser Ala Phe 
                165                 170                 175     


Val Phe Pro Thr Lys Asp Val Ala Leu Arg His Val Val Cys Ala His 
            180                 185                 190         


Glu Leu Val Cys Ser Met Glu Asn Thr Arg Ala Thr Lys Met Gln Val 
        195                 200                 205             


Ile Gly Asp Gln Tyr Val Lys Val Tyr Leu Glu Ser Phe Cys Glu Asp 
    210                 215                 220                 


Val Pro Ser Gly Lys Leu Phe Met His Val Thr Leu Gly Ser Asp Val 
225                 230                 235                 240 


Glu Glu Asp Leu Thr Met Thr Arg Asn Pro Gln Pro Phe Met Arg Pro 
                245                 250                 255     


His Glu Arg Asn Gly Phe Thr Val Leu Cys Pro Lys Asn Met Ile Ile 
            260                 265                 270         


Lys Pro Gly Lys Ile Ser His Ile Met Leu Asp Val Ala Phe Thr Ser 
        275                 280                 285             


His Glu His Phe Gly Leu Leu Cys Pro Lys Ser Ile Pro Gly Leu Ser 
    290                 295                 300                 


Ile Ser Gly Asn Leu Leu Met Asn Gly Gln Gln Ile Phe Leu Glu Val 
305                 310                 315                 320 


Gln Ala Ile Arg Glu Thr Val Glu Leu Arg Gln Tyr Asp Pro Val Ala 
                325                 330                 335     


Ala Leu Phe Phe Phe Asp Ile Asp Leu Leu Leu Gln Arg Gly Pro Gln 
            340                 345                 350         


Tyr Ser Glu His Pro Thr Phe Thr Ser Gln Tyr Arg Ile Gln Gly Lys 
        355                 360                 365             


Leu Glu Tyr Arg His Thr Trp Asp Arg His Asp Glu Gly Ala Ala Gln 
    370                 375                 380                 


Gly Asp Asp Asp Val Trp Thr Ser Gly Ser Asp Ser Asp Glu Glu Leu 
385                 390                 395                 400 


Val Thr Thr Glu Arg Lys Thr Pro Arg Val Thr Gly Gly Gly Ala Met 
                405                 410                 415     


Ala Gly Ala Ser Thr Ser Ala Gly Arg Lys Arg Lys Ser Ala Ser Ser 
            420                 425                 430         


Ala Thr Ala Cys Thr Ala Gly Val Met Thr Arg Gly Arg Leu Lys Ala 
        435                 440                 445             


Glu Ser Thr Val Ala Pro Glu Glu Asp Thr Asp Glu Asp Ser Asp Asn 
    450                 455                 460                 


Glu Ile His Asn Pro Ala Val Phe Thr Trp Pro Pro Trp Gln Ala Gly 
465                 470                 475                 480 


Ile Leu Ala Arg Asn Leu Val Pro Met Val Ala Thr Val Gln Gly Gln 
                485                 490                 495     


Asn Leu Lys Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg 
            500                 505                 510         


Ile Phe Ala Glu Leu Glu Gly Val Trp Gln Pro Ala Ala Gln Pro Lys 
        515                 520                 525             


Arg Arg Arg His Arg Gln Asp Ala Leu Pro Gly Pro Cys Ile Ala Ser 
    530                 535                 540                 


Thr Pro Lys Lys His Arg Gly 
545                 550     


<210>  98
<211>  353
<212>  PRT
<213>  Human T-lymphotropic virus 1]

<400>  98

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Phe Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Gly Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Ile 
    50                  55                  60                  


Gly Ser Ala Leu Gln Phe Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Ile Thr His 
                85                  90                  95      


Thr Thr Pro Asn Ile Pro Pro Ser Phe Leu Gln Ala Met Arg Lys Tyr 
            100                 105                 110         


Ser Pro Phe Arg Asn Gly Tyr Met Glu Pro Thr Leu Gly Gln His Leu 
        115                 120                 125             


Pro Thr Leu Ser Phe Pro Asp Pro Gly Leu Arg Pro Gln Asn Leu Tyr 
    130                 135                 140                 


Thr Leu Trp Gly Gly Ser Val Val Cys Met Tyr Leu Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Ile Thr Trp Pro Leu Leu Pro His Val Ile Phe Cys His Pro 
                165                 170                 175     


Gly Gln Leu Gly Ala Phe Leu Thr Asn Val Pro Tyr Lys Arg Ile Glu 
            180                 185                 190         


Lys Leu Leu Tyr Lys Ile Ser Leu Thr Thr Gly Ala Leu Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Cys Leu Pro Thr Thr Leu Phe Gln Pro Ala Arg Ala Pro 
    210                 215                 220                 


Val Thr Leu Thr Ala Trp Gln Asn Gly Leu Leu Pro Phe His Ser Thr 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Thr Asp Gly Thr Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Asp Gly Gln Pro Ser Leu Val Leu Gln 
            260                 265                 270         


Ser Ser Ser Phe Ile Phe His Lys Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Phe Leu Leu Ser His Gly Leu Ile Gln Tyr Ser Ser Phe His Asn 
    290                 295                 300                 


Leu His Leu Leu Phe Glu Glu Tyr Thr Asn Ile Pro Ile Ser Leu Leu 
305                 310                 315                 320 


Phe Asn Glu Lys Glu Ala Asp Asp Asn Asp His Glu Pro Gln Ile Ser 
                325                 330                 335     


Pro Gly Gly Leu Glu Pro Leu Ser Glu Lys His Phe Arg Glu Thr Glu 
            340                 345                 350         


Val 
    


<210>  99
<211>  345
<212>  PRT
<213>  Human T-lymphotropic virus 1]

<400>  99

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Tyr Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Ala Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Pro Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Val 
    50                  55                  60                  


Gly Ser Pro Leu Gln Tyr Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Thr Thr Pro 
                85                  90                  95      


Val Thr Pro Lys Val Pro Pro Ser Phe Phe Gln Ser Val Arg Arg His 
            100                 105                 110         


Ser Pro Tyr Arg Asn Gly Cys Leu Glu Thr Thr Leu Gly Glu Gln Leu 
        115                 120                 125             


Pro Ser Leu Ala Phe Pro Glu Pro Gly Leu Arg Pro Gln Asn Val Tyr 
    130                 135                 140                 


Thr Ile Trp Gly Lys Thr Ile Val Cys Leu Tyr Ile Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Met Thr Trp Pro Leu Ile Pro His Val Ile Phe Cys Asn Pro 
                165                 170                 175     


Arg Gln Leu Gly Ala Phe Leu Ser Asn Val Pro Pro Lys Arg Leu Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Leu Tyr Leu His Thr Gly Ala Ile Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Ala Leu Pro Thr Thr Leu Phe Gln Pro Val Arg Ala Pro 
    210                 215                 220                 


Cys Val Gln Thr Thr Trp Asn Thr Gly Leu Leu Pro Tyr Gln Pro Asn 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Asn Asp Gly Ser Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Ala Gly Gln Pro Ser Leu Val Val Gln 
            260                 265                 270         


Ser Ser Leu Leu Ile Phe Glu Arg Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Tyr Leu Leu Ser His Gln Leu Ile Gln Tyr Ser Ser Phe His His 
    290                 295                 300                 


Leu Tyr Leu Leu Phe Asp Glu Tyr Thr Thr Ile Pro Phe Ser Leu Leu 
305                 310                 315                 320 


Phe Lys Glu Lys Glu Gly Asp Asp Arg Asp Asn Asp Pro Leu Pro Gly 
                325                 330                 335     


Ala Thr Ala Ser Pro Gln Gly Gln Asn 
            340                 345 


<210>  100

<400>  100
000

<210>  101
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  101

Ser Thr Asn Arg Gln Ser Gly Arg Gln 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  102

Leu Leu Phe Gly Tyr Pro Val Tyr Val 
1               5                   


<210>  103
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  103

Gly Leu Ser Pro Thr Val Trp Leu Ser Val 
1               5                   10  


<210>  104
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  104

Ala Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  105
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  105

Tyr Ala Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  106

Tyr Met Ala Gly Thr Met Ser Gln Val 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  107

Tyr Met Asp Ala Thr Met Ser Gln Val 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  108

Tyr Met Asp Gly Ala Met Ser Gln Val 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  109

Tyr Met Asp Gly Thr Ala Ser Gln Val 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  110

Tyr Met Asp Gly Thr Met Ala Gln Val 
1               5                   


<210>  111
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  111

Tyr Met Asp Gly Thr Met Ser Ala Val 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  112

Tyr Met Asp Gly Thr Met Ser Gln Ala 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  113

Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  114
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  114

Tyr Met Asn Gly Thr Met Ser Gln Val 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  115

Tyr Met Asp Asn Val Met Ser Glu Val 
1               5                   


<210>  116
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  116

Val Met Asp Ser Lys Ile Val Gln Val 
1               5                   


<210>  117
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  117

Leu Met Asn Gly Thr Leu Lys Gln Val 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  118

Ser Gln Asp Gly Thr Arg Ser Gln Val 
1               5                   


<210>  119
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  119

Val Met Asp Thr Thr Lys Ser Gln Val 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  120

Gly Met Asp Gly Thr Gln Gln Gln Ile 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  121

Gly Met Val Gly Thr Met Thr Glu Val 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  122

Met Met Asp Ala Thr Phe Ser Ala Val 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  123

Gln Met Asp Pro Thr Gly Ser Gln Leu 
1               5                   


<210>  124
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  124

Ser Met Asp Gly Ser Met Arg Thr Val 
1               5                   


<210>  125
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  125

Trp Met Asp Gly Ile Ala Ser Gln Ile 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  126

Tyr Leu Glu Gly Ile Leu Ser Gln Val 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  127

Tyr Met Ala Ile Lys Met Ser Gln Leu 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  128

Tyr Met Asp Ala Val Val Ser Leu Val 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  129

Tyr Met Asp Gly Thr Asn Arg Arg Ile 
1               5                   


<210>  130
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  130

Tyr Met Asp Pro Ser Thr Tyr Gln Val 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  131

Tyr Met Leu Gly Thr Asn His Gln Leu 
1               5                   


<210>  132
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  132

Tyr Met Pro Gly Thr Ala Ser Leu Ile 
1               5                   


<210>  133
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  133

Tyr Met Arg Glu Thr Arg Ser Gln Leu 
1               5                   


<210>  134
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  134

Met Met Asp Gly Ala Met Gly Tyr Val 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  135

Asn Met Asp Ser Phe Met Ala Gln Val 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  136

Gln Met Asp Phe Ile Met Ser Cys Val 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  137

Tyr Glu Asp Leu Lys Met Tyr Gln Val 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  138

Tyr Met Asp Thr Ile Met Glu Leu Val 
1               5                   


<210>  139
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  139

Tyr Thr Asp Leu Ala Met Ser Thr Val 
1               5                   


<210>  140
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  140

Tyr Val Asp Phe Val Met Ser Ser Val 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  141

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  142

Leu Asp Phe Pro Asn Leu Pro Tyr Leu 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  143

Arg Cys Phe Pro Asn Cys Pro Phe Leu 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  144

Leu Met Phe Glu Asn Ala Ala Tyr Leu 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  145

Arg Met Phe Pro Asn Lys Tyr Ser Leu 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  146

Arg Leu Phe Pro Asn Ala Lys Phe Leu 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  147

Arg Leu Phe Pro Asn Leu Pro Glu Leu 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  148

Arg Met Phe Pro Thr Pro Pro Ser Leu 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  149

Arg Met Val Pro Arg Ala Val Tyr Leu 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  150

Arg Met Phe Phe Asn Gly Arg Tyr Ile 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  151

Arg Met Leu Pro His Ala Pro Gly Val 
1               5                   


<210>  152
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  152

Tyr Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  153

Ala Met Asp Pro Asn Ala Ala Tyr Val 
1               5                   


<210>  154
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  154

Ile Cys Phe Pro Asn Ala Pro Lys Val 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  155

Asn Met Phe Glu Asn Gly Cys Tyr Leu 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  156

Asn Met Pro Pro Asn Phe Pro Tyr Ile 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  157

Arg Glu Met Thr Gln Ala Pro Tyr Leu 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  158

Arg Met Ala Pro Arg Ala Pro Trp Ile 
1               5                   


<210>  159
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  159

Arg Met Glu Pro Arg Ala Pro Trp Ile 
1               5                   


<210>  160
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  160

Arg Met Glu Pro Arg Ala Pro Trp Val 
1               5                   


<210>  161
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  161

Arg Met Phe Leu Asn Asn Pro Ser Ile 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  162

Arg Met Phe Gln Gln Thr Phe Tyr Leu 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  163

Arg Met Asn Pro Asn Ser Pro Ser Ile 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  164

Arg Gln Phe Pro Asn Ala Ser Leu Ile 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  165

Arg Gln Phe Pro Asn Lys Asp Ala Leu 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  166

Arg Val Phe Pro Trp Ala Ser Ser Leu 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  167

Arg Leu Phe Pro Trp Gly Asn Lys Leu 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  168

Ala Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  169

Arg Ala Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  170

Arg Met Ala Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  171
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  171

Arg Met Phe Ala Asn Ala Pro Tyr Leu 
1               5                   


<210>  172
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  172

Arg Met Phe Pro Ala Ala Pro Tyr Leu 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  173

Arg Met Phe Pro Asn Ala Ala Tyr Leu 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  174

Arg Met Phe Pro Asn Ala Pro Ala Leu 
1               5                   


<210>  175
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  175

Arg Met Phe Pro Asn Ala Pro Tyr Ala 
1               5                   


<210>  176
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  176

Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  177
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  177

Gly Leu Ala Asp Gly Arg Thr His Thr Val 
1               5                   10  


<210>  178
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  178

Gly Val Ser Asp Gly Arg Trp His Ser Val 
1               5                   10  


<210>  179
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  179

Gly Val Tyr Asp Gly Glu Glu His Ser Val 
1               5                   10  


<210>  180
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  180

Gly Leu Tyr Asp Gly Met Glu His Leu 
1               5                   


<210>  181
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  181

Gly Val Ser Asp Gly Gln Trp His Thr Val 
1               5                   10  


<210>  182
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  182

Gly Val Tyr Ala Gly Arg Glu His Phe Leu 
1               5                   10  


<210>  183
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  183

Gly Leu Tyr Asp Gly Met Glu His Leu Ile 
1               5                   10  


<210>  184
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  184

Ala Ser Tyr Asp Gly Thr Glu Val Thr Val 
1               5                   10  


<210>  185
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  185

Ala Val Leu Asp Gly Arg Glu Leu Arg Val 
1               5                   10  


<210>  186
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  186

Gly Leu Tyr Asp Gly Ile Glu His Phe Met 
1               5                   10  


<210>  187
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  187

Gly Leu Tyr Asp Gly Pro Val His Glu Val 
1               5                   10  


<210>  188
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  188

Gly Val Cys Ala Gly Arg Glu His Phe Ile 
1               5                   10  


<210>  189
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  189

Gly Val Tyr Ala Gly Arg Pro Leu Ser Val 
1               5                   10  


<210>  190
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  190

Thr Val Tyr Asp Leu Arg Glu Gln Ser Val 
1               5                   10  


<210>  191
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  191

Val Val Asp Asp Gly Val Glu His Thr Ile 
1               5                   10  


<210>  192
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  192

Gly Val Phe Asp Gly Leu His Thr Val 
1               5                   


<210>  193
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  193

Ala Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  194
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  194

Gly Ala Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  195
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  195

Gly Val Ala Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  196
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  196

Gly Val Tyr Ala Gly Arg Glu His Thr Val 
1               5                   10  


<210>  197
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  197

Gly Val Tyr Asp Ala Arg Glu His Thr Val 
1               5                   10  


<210>  198
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  198

Gly Val Tyr Asp Gly Ala Glu His Thr Val 
1               5                   10  


<210>  199
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  199

Gly Val Tyr Asp Gly Arg Ala His Thr Val 
1               5                   10  


<210>  200
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  200

Gly Val Tyr Asp Gly Arg Glu Ala Thr Val 
1               5                   10  


<210>  201
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  201

Gly Val Tyr Asp Gly Arg Glu His Ala Val 
1               5                   10  


<210>  202
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  202

Gly Val Tyr Asp Gly Arg Glu His Thr Ala 
1               5                   10  


<210>  203
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  203

Ala Leu Ser Val Met Gly Val Tyr Val 
1               5                   


<210>  204
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  204

Ala Leu Ser Val Leu Gly Val Met Val 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  205

Ala Leu Ser Arg Lys Gly Ile Tyr Val 
1               5                   


<210>  206
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  206

Ala Leu Ser Val Met Tyr Ser Tyr Leu 
1               5                   


<210>  207
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  207

Ala Val Ser His Met Gly Val Leu Val 
1               5                   


<210>  208
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  208

Leu Leu Ser Leu Met Gly Val Leu Val 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  209

Val Leu Ser Ile Met Gly Val Tyr Ala 
1               5                   


<210>  210
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  210

Ala Leu Gln Val Arg Lys Val Tyr Val 
1               5                   


<210>  211
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  211

Ala Leu Gln Val Tyr Gly Val Glu Val 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  212

Ala Leu Ser Val Ala Gly Gly Phe Val 
1               5                   


<210>  213
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  213

Ala Leu Ser Val Leu Gly Lys Val Val 
1               5                   


<210>  214
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  214

Ala Leu Ser Val Met Ile Pro Ala Val 
1               5                   


<210>  215
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  215

Asp Leu Ser Val Cys Ser Val Tyr Val 
1               5                   


<210>  216
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  216

Ile Leu Gly Val Met Gly Val Asp Val 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  217

Leu Leu Ser Val Asn Gly Val Ser Val 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  218

Ser Leu Ser Pro Met Gly Arg Tyr Val 
1               5                   


<210>  219
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  219

Ala Leu Ser Ala Val Met Gly Val Thr Leu 
1               5                   10  


<210>  220
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  220

Ala Ile Leu Leu Val Met Gly Val Asp Val 
1               5                   10  


<210>  221
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  221

Ala Leu Ser Asp His His Val Tyr Leu 
1               5                   


<210>  222
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  222

Ala Ala Ser Val Met Gly Val Tyr Val 
1               5                   


<210>  223
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  223

Ala Leu Ala Val Met Gly Val Tyr Val 
1               5                   


<210>  224
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  224

Ala Leu Ser Ala Met Gly Val Tyr Val 
1               5                   


<210>  225
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  225

Ala Leu Ser Val Ala Gly Val Tyr Val 
1               5                   


<210>  226
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  226

Ala Leu Ser Val Met Ala Val Tyr Val 
1               5                   


<210>  227
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  227

Ala Leu Ser Val Met Gly Ala Tyr Val 
1               5                   


<210>  228
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  228

Ala Leu Ser Val Met Gly Val Ala Val 
1               5                   


<210>  229
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  229

Ala Leu Ser Val Met Gly Val Tyr Ala 
1               5                   


<210>  230
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  230

Thr Leu Met Ser Ala Met Thr Asn Leu 
1               5                   


<210>  231
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  231

Thr Leu Met Ser Ala Glu Ala Asn Leu 
1               5                   


<210>  232
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  232

Gln Leu Cys Ser Ala Met Thr Gln Leu 
1               5                   


<210>  233
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  233

Arg Leu Met Ser Ala Leu Thr Gln Leu 
1               5                   


<210>  234
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  234

Gly Leu Met Ser Leu Thr Thr Asn Leu 
1               5                   


<210>  235
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  235

Gly Leu Met Ser Met Ala Thr Asn Leu 
1               5                   


<210>  236
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  236

Gly Leu Met Ser Met Thr Thr Asn Leu 
1               5                   


<210>  237
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  237

Leu Leu Met Ser Ile Ser Thr Asn Leu 
1               5                   


<210>  238
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  238

Gln Leu Pro Ser Thr Met Thr Asn Leu 
1               5                   


<210>  239
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  239

Thr Leu Ala Ser Ser Met Gly Asn Leu 
1               5                   


<210>  240
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  240

Thr Leu Phe Ser Ala Leu Thr Gly Leu 
1               5                   


<210>  241
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  241

Thr Leu Gly Ser Ala Thr Thr Glu Leu 
1               5                   


<210>  242
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  242

Thr Leu Met Arg Ala Met Thr Asp Cys 
1               5                   


<210>  243
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  243

Thr Leu Met Ser Met Val Ala Asn Leu 
1               5                   


<210>  244
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  244

Thr Leu Pro Ser Ala Glu Thr Ala Leu 
1               5                   


<210>  245
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  245

Thr Leu Pro Ser Arg Met Thr Val Leu 
1               5                   


<210>  246
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  246

Arg Leu Met Ser Ala Leu Thr Gln Val 
1               5                   


<210>  247
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  247

Ser Ile His Ser Gln Met Thr Asn Leu 
1               5                   


<210>  248
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  248

Ser Ile Met Phe Ala Met Thr Pro Leu 
1               5                   


<210>  249
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  249

Thr Ile Val Ala Ala Met Ser Asn Leu 
1               5                   


<210>  250
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  250

Thr Leu Ile Thr Ala Met Glu Gln Leu 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  251

Thr Leu Thr Ser Asn Met Ser Gln Leu 
1               5                   


<210>  252
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  252

Ala Leu Met Ser Ala Met Thr Asn Leu 
1               5                   


<210>  253
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  253

Thr Leu Ala Ser Ala Met Thr Asn Leu 
1               5                   


<210>  254
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  254

Thr Leu Met Ala Ala Met Thr Asn Leu 
1               5                   


<210>  255
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  255

Thr Leu Met Ser Ala Ala Thr Asn Leu 
1               5                   


<210>  256
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  256

Thr Leu Met Ser Ala Met Ala Asn Leu 
1               5                   


<210>  257
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  257

Thr Leu Met Ser Ala Met Thr Ala Leu 
1               5                   


<210>  258
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  258

Thr Leu Met Ser Ala Met Thr Asn Ala 
1               5                   


<210>  259
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  259

Val Met Asp Ser Lys Ile Val Gln Val 
1               5                   


<210>  260
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  260

Arg Met Leu Pro His Ala Pro Gly Val 
1               5                   


<210>  261
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  261

Ala Met Asp Pro Asn Ala Ala Tyr Val 
1               5                   


<210>  262
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  262

Arg Met Asn Pro Asn Ser Pro Ser Ile 
1               5                   


<210>  263
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  263

Gly Leu Ala Asp Gly Arg Thr His Thr Val 
1               5                   10  


<210>  264
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  264

Gly Leu Tyr Asp Gly Pro Val His Glu Val 
1               5                   10  


<210>  265
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  265

Gly Val Phe Asp Gly Leu His Thr Val 
1               5                   


<210>  266
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  266

Ala Leu Ser Asp His His Val Tyr Leu 
1               5                   


<210>  267
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  267

Arg Leu Met Ser Ala Leu Thr Gln Leu 
1               5                   


<210>  268
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  268

Arg Leu Met Ser Ala Leu Thr Gln Val 
1               5                   


<210>  269
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  269

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  270
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  270

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  271
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  271

Ser Leu Tyr Asn Thr Val Ala Thr Leu 
1               5                   


<210>  272
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  272

Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  273
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  273

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  274
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  274

Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  275
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  275

Thr Leu Met Ser Ala Met Thr Asn Leu 
1               5                   


<210>  276
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  276

Ala Leu Ser Val Met Gly Val Tyr Val 
1               5                   


<210>  277
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  277

Lys Ala Ser Glu Lys Ile Phe Tyr Val 
1               5                   


<210>  278
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  278

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  279
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  short peptide

<400>  279

Thr Leu Phe Asp Tyr Glu Val Arg Leu 
1               5                   


<210>  280
<211>  702
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D11 light chain

<400>  280
atgagaccgt ctattcagtt cctggggctc ttgttgttct ggcttcatgg tgctcagtgt       60

gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc      120

atcacatgca aggcaagcca agacattcac aactatatag cttggtacca acacaagcct      180

gtaaaaggtc ctaggctgct catacattac acatctacat tacagccagg caccccatca      240

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      300

gaagatattg caacttatta ttgtctacag tatgataatc tgtggacgtt cggtggaggc      360

accaagctgg aaatcaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      420

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      480

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      540

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      600

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      660

acttcaccca ttgtcaagag cttcaacagg aatgagtgtt ag                         702


<210>  281
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D11 light chain

<400>  281

Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile His Asn Tyr Ile Ala Trp Tyr Gln His Lys Pro Val Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Thr Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  282
<211>  1398
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D11 heavy chain

<400>  282
atggacaggc ttacttcctc attcctgctg ctgattgtcc ctgcatatgt cctttcccag       60

gtaactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact      120

tgttctttct ctgggttttc actgaccact tctggtatgg gtgtgagctg gattcgtcag      180

ccttcaggaa agggtctgga gtggctggca cacatttact gggatgatga caagcgctat      240

aacccatccc tgaagagccg actcacaatc tccaaggata cctccagaaa ccaggtattc      300

ctcaagatca ccagtgtgga cgctgcagat actgccacat actactgtgc tcgaaaggac      360

tacggtagta gcttctatgc tatgcactac tggggtcaag gaacctcagt caccgtctcc      420

tcagccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc tgcccaaact      480

aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc agtgacagtg      540

acctggaact ctggatccct gtccagcggt gtgcacacct tcccagctgt cctgcagtct      600

gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc cagcgagacc      660

gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa aattgtgccc      720

agggattgtg gttgtaagcc ttgcatatgt acagtcccag aagtatcatc tgtcttcatc      780

ttccccccaa agcccaagga tgtgctcacc attactctga ctcctaaggt cacgtgtgtt      840

gtggtagaca tcagcaagga tgatcccgag gtccagttca gctggtttgt agatgatgtg      900

gaggtgcaca cagctcagac gcaaccccgg gaggagcagt tcaacagcac tttccgctca      960

gtcagtgaac ttcccatcat gcaccaggac tggctcaatg gcaaggagtt caaatgcagg     1020

gtcaacagtg cagctttccc tgcccccatc gagaaaacca tctccaaaac caaaggcaga     1080

ccgaaggctc cacaggtgta caccattcca cctcccaagg agcagatggc caaggataaa     1140

gtcagtctga cctgcatgat aacagacttc ttccctgaag acattactgt ggagtggcag     1200

tggaatgggc agccagcgga gaactacaag aacactcagc ccatcatgga cacagatggc     1260

tcttacttcg tctacagcaa gctcaatgtg cagaagagca actgggaggc aggaaatact     1320

ttcacctgct ctgtgttaca tgagggcctg cacaaccacc atactgagaa gagcctctcc     1380

cactctcctg gtaaatga                                                   1398


<210>  283
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D11 heavy chain

<400>  283

Met Asp Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Ala Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Lys Asp Tyr Gly Ser Ser Phe Tyr Ala Met 
        115                 120                 125             


His Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
145                 150                 155                 160 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
225                 230                 235                 240 


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
                245                 250                 255     


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
            260                 265                 270         


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
    290                 295                 300                 


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
305                 310                 315                 320 


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
        355                 360                 365             


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
    370                 375                 380                 


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
385                 390                 395                 400 


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
                405                 410                 415     


Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
            420                 425                 430         


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
        435                 440                 445             


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  284
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D11 light chain CDR

<400>  284
aaggcaagcc aagacattca caactatata gct                                    33


<210>  285
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D11 light chain CDR

<400>  285
tacacatcta cattacagcc a                                                 21


<210>  286
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D11 light chain CDR

<400>  286
ctacagtatg ataatctgtg gacg                                              24


<210>  287
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D11 light chain CDR

<400>  287

Lys Ala Ser Gln Asp Ile His Asn Tyr Ile Ala 
1               5                   10      


<210>  288
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D11 light chain CDR

<400>  288

Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210>  289
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D11 light chain CDR

<400>  289

Leu Gln Tyr Asp Asn Leu Trp Thr 
1               5               


<210>  290
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D11 heavy chain CDR

<400>  290
acttctggta tgggtgtgag c                                                 21


<210>  291
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D11 heavy chain CDR

<400>  291
cacatttact gggatgatga caagcgctat aacccatccc tgaagagc                    48


<210>  292
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D11 heavy chain CDR

<400>  292
aaggactacg gtagtagctt ctatgctatg cactac                                 36


<210>  293
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D11 heavy chain CDR

<400>  293

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  294
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D11 heavy chain CDR

<400>  294

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  295
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D11 heavy chain CDR

<400>  295

Lys Asp Tyr Gly Ser Ser Phe Tyr Ala Met His Tyr 
1               5                   10          


<210>  296
<211>  705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D7 light chain

<400>  296
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgt       60

gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc      120

atcacatgtc gagcaagtga tattatttac agtaatttag catggtatca gcagaaacag      180

ggaaaatctc ctcagctcct ggtctatgct gcaacaaact tagcagctgg tgtgccatca      240

aggttcagtg gcagtggatc aggcacacag tattccctca agatcaatag cctgcagtct      300

gaagattttg ggacttatta ctgtcaacat ttttggggta gttcaatctc gttcggctcg      360

gggacaaagt tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                      705


<210>  297
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D7 light chain

<400>  297

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Val Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Asp Ile 
        35                  40                  45              


Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Val Tyr Ala Ala Thr Asn Leu Ala Ala Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp 
            100                 105                 110         


Gly Ser Ser Ile Ser Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  298
<211>  1380
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D7 heavy chain

<400>  298
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcaactga aggaatcagg acctggtctg gtggcgccct cacagagcct gtccatcact      120

tgcactgtct ctgggttttc attaaccagc tatggtgtac actgggttcg ccagcctcca      180

ggaaagggtc tggagtggct gggagtaata tgggctggtg gaaccacaaa ttataattcg      240

gctctcatgt ccagactgag catcagcaga gacaactcca agagccaagt tttcttagaa      300

atgaacagtc tgcaaactga tgacacagcc atttactact gtgccagaga tggtcacttc      360

cactttgact tctggggcca aggcaccact ctcacagtct cctcagccaa aacgacaccc      420

ccatctgtct atccactggc ccctggatct gctgcccaaa ctaactccat ggtgaccctg      480

ggatgcctgg tcaagggcta tttccctgag ccagtgacag tgacctggaa ctctggatcc      540

ctgtccagcg gtgtgcacac cttcccagct gtcctgcagt ctgacctcta cactctgagc      600

agctcagtga ctgtcccctc cagcacctgg cccagcgaga ccgtcacctg caacgttgcc      660

cacccggcca gcagcaccaa ggtggacaag aaaattgtgc ccagggattg tggttgtaag      720

ccttgcatat gtacagtccc agaagtatca tctgtcttca tcttcccccc aaagcccaag      780

gatgtgctca ccattactct gactcctaag gtcacgtgtg ttgtggtaga catcagcaag      840

gatgatcccg aggtccagtt cagctggttt gtagatgatg tggaggtgca cacagctcag      900

acgcaacccc gggaggagca gttcaacagc actttccgct cagtcagtga acttcccatc      960

atgcaccagg actggctcaa tggcaaggag ttcaaatgca gggtcaacag tgcagctttc     1020

cctgccccca tcgagaaaac catctccaaa accaaaggca gaccgaaggc tccacaggtg     1080

tacaccattc cacctcccaa ggagcagatg gccaaggata aagtcagtct gacctgcatg     1140

ataacagact tcttccctga agacattact gtggagtggc agtggaatgg gcagccagcg     1200

gagaactaca agaacactca gcccatcatg gacacagatg gctcttactt cgtctacagc     1260

aagctcaatg tgcagaagag caactgggag gcaggaaata ctttcacctg ctctgtgtta     1320

catgagggcc tgcacaacca ccatactgag aagagcctct cccactctcc tggtaaatga     1380


<210>  299
<211>  459
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D7 heavy chain

<400>  299

Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Thr Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Glu Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Gly His Phe His Phe Asp Phe Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
        195                 200                 205             


Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
    210                 215                 220                 


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
225                 230                 235                 240 


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
        275                 280                 285             


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
305                 310                 315                 320 


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
                325                 330                 335     


Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            340                 345                 350         


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
        355                 360                 365             


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe 
    370                 375                 380                 


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
385                 390                 395                 400 


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr 
                405                 410                 415     


Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
            420                 425                 430         


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
        435                 440                 445             


Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 


<210>  300
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D7 light chain CDR

<400>  300
cgagcaagtg atattattta cagtaattta gca                                    33


<210>  301
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D7 light chain CDR

<400>  301
gctgcaacaa acttagcagc t                                                 21


<210>  302
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D7 light chain CDR

<400>  302
caacattttt ggggtagttc aatctcg                                           27


<210>  303
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D7 light chain CDR

<400>  303

Arg Ala Ser Asp Ile Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  304
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D7 light chain CDR

<400>  304

Ala Ala Thr Asn Leu Ala Ala 
1               5           


<210>  305
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D7 light chain CDR

<400>  305

Gln His Phe Trp Gly Ser Ser Ile Ser 
1               5                   


<210>  306
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D7 heavy chain CDR

<400>  306
agctatggtg tacac                                                        15


<210>  307
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D7 heavy chain CDR

<400>  307
gtaatatggg ctggtggaac cacaaattat aattcggctc tcatgtcc                    48


<210>  308
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D7 heavy chain CDR

<400>  308
gatggtcact tccactttga cttc                                              24


<210>  309
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D7 heavy chain CDR

<400>  309

Ser Tyr Gly Val His 
1               5   


<210>  310
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D7 heavy chain CDR

<400>  310

Val Ile Trp Ala Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  311
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D7 heavy chain CDR

<400>  311

Asp Gly His Phe His Phe Asp Phe 
1               5               


<210>  312
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of B47B6 light chain

<400>  312
gatattgtgc tcactcagtc tccagccacc ctgtctgtga gtccaggaga tagcgtcagt       60

ctttcctgca gggccagcca aagtattagc aacagcctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg aatcccctct      180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      240

gaagattttg gaatgtattt ctgtcaacag agttacagct ggcctctcac gttcggtgct      300

gggtccaagc tggagctgaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         642


<210>  313
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of B47B6 light chain

<400>  313

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Tyr Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Ser Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  314
<211>  1323
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of B47B6 heavy chain

<400>  314
gaagtgcagt tggtggagtc ggggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cgttttcagt agctatgaca tgtcttgggt tcgccaggct      120

caggagaaga ggctggagtg ggtcgcatac atgagtagtg gtggcggcac ctactatcca      180

gacactgtga agggccgatt caccatctcc agagacaatg ccaagaacac cctgcacctg      240

caaatgagca gcctgaagtc tgaggacaca gccatgtatt actgtgcaag acatgatgag      300

attactaact ttgactactg gggccaaggc accactctca cagtctcctc agccaaaacg      360

acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg      420

accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct      480

ggatccctgt ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga cctctacact      540

ctgagcagct cagtgactgt cccctccagc acctggccca gcgagaccgt cacctgcaac      600

gttgcccacc cggccagcag caccaaggtg gacaagaaaa ttgtgcccag ggattgtggt      660

tgtaagcctt gcatatgtac agtcccagaa gtatcatctg tcttcatctt ccccccaaag      720

cccaaggatg tgctcaccat tactctgact cctaaggtca cgtgtgttgt ggtagacatc      780

agcaaggatg atcccgaggt ccagttcagc tggtttgtag atgatgtgga ggtgcacaca      840

gctcagacgc aaccccggga ggagcagttc aacagcactt tccgctcagt cagtgaactt      900

cccatcatgc accaggactg gctcaatggc aaggagttca aatgcagggt caacagtgca      960

gctttccctg cccccatcga gaaaaccatc tccaaaacca aaggcagacc gaaggctcca     1020

caggtgtaca ccattccacc tcccaaggag cagatggcca aggataaagt cagtctgacc     1080

tgcatgataa cagacttctt ccctgaagac attactgtgg agtggcagtg gaatgggcag     1140

ccagcggaga actacaagaa cactcagccc atcatggaca cagatggctc ttacttcgtc     1200

tacagcaagc tcaatgtgca gaagagcaac tgggaggcag gaaatacttt cacctgctct     1260

gtgttacatg agggcctgca caaccaccat actgagaaga gcctctccca ctctcctggt     1320

aaa                                                                   1323


<210>  315
<211>  441
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of B47B6 heavy chain

<400>  315

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Val Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Gln Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Met Ser Ser Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu His Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Asp Glu Ile Thr Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440     


<210>  316
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of B47B6 light chain CDR

<400>  316
agggccagcc aaagtattag caacagccta cac                                    33


<210>  317
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of B47B6 light chain CDR

<400>  317
tatgcttccc agtccatctc t                                                 21


<210>  318
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of B47B6 light chain CDR

<400>  318
caacagagtt acagctggcc tctcacg                                           27


<210>  319
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of B47B6 light chain CDR

<400>  319

Arg Ala Ser Gln Ser Ile Ser Asn Ser Leu His 
1               5                   10      


<210>  320
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of B47B6 light chain CDR

<400>  320

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  321
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of B47B6 light chain CDR

<400>  321

Gln Gln Ser Tyr Ser Trp Pro Leu Thr 
1               5                   


<210>  322
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of B47B6  heavy chain CDR

<400>  322
agctatgaca tgtct                                                        15


<210>  323
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of B47B6  heavy chain CDR

<400>  323
tacatgagta gtggtggcgg cacctactat ccagacactg tgaagggc                    48


<210>  324
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of B47B6  heavy chain CDR

<400>  324
catgatgaga ttactaactt tgactac                                           27


<210>  325
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of B47B6  heavy chain CDR

<400>  325

Ser Tyr Asp Met Ser 
1               5   


<210>  326
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of B47B6 heavy chain CDR

<400>  326

Tyr Met Ser Ser Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  327
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of B47B6 heavy chain CDR

<400>  327

His Asp Glu Ile Thr Asn Phe Asp Tyr 
1               5                   


<210>  328
<211>  639
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of C106B9 light chain

<400>  328
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgtcagctc aagtgtagat tacattcact ggttccagca gaagccaggc      120

acttctccca aattctggat ttatagcaca tccatcctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttacc cacccacgtt cggctcgggg      300

acaaagttgg aaataaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      360

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      420

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      480

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      540

accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca      600

acttcaccca ttgtcaagag cttcaacagg aatgagtgt                             639


<210>  329
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of C106B9 light chain

<400>  329

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Val Asp Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Phe Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  330
<211>  1320
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of C106B9 heavy chain

<400>  330
caggttcaac tgcagcagtc tggaggtgag gtgatgaagc ctggggcctc agtgaagctt       60

tcctgcaagg ctactggcta cacattcact ggctactgga tagagtggat aaaacagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaagtggtgg tactaactac      180

aatgagaaat tcaagggcaa ggccacattc actgcacata catcctccaa cacagcctac      240

atgcaactca gcagcctgac aactgaggac tctgccatct attactgtgc aagggatagt      300

aactccttta cttactgggg ccaagggact ctggtcactg tctcttcagc caaaacgaca      360

cccccatctg tctatccact ggcccctgga tctgctgccc aaactaactc catggtgacc      420

ctgggatgcc tggtcaaggg ctatttccct gagccagtga cagtgacctg gaactctgga      480

tccctgtcca gcggtgtgca caccttccca gctgtcctgc agtctgacct ctacactctg      540

agcagctcag tgactgtccc ctccagcacc tggcccagcg agaccgtcac ctgcaacgtt      600

gcccacccgg ccagcagcac caaggtggac aagaaaattg tgcccaggga ttgtggttgt      660

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      720

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      780

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      840

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      900

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa cagtgcagct      960

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag     1020

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc     1080

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca     1140

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac     1200

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg     1260

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1320


<210>  331
<211>  440
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of C106B9 heavy chain

<400>  331

Gln Val Gln Leu Gln Gln Ser Gly Gly Glu Val Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala His Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Asn Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
    210                 215                 220                 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
            260                 265                 270         


Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
305                 310                 315                 320 


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
                325                 330                 335     


Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
            340                 345                 350         


Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu 
        355                 360                 365             


Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
    370                 375                 380                 


Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 
385                 390                 395                 400 


Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
                405                 410                 415     


Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys 
            420                 425                 430         


Ser Leu Ser His Ser Pro Gly Lys 
        435                 440 


<210>  332
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of C106B9 light chain CDR

<400>  332
agtgtcagct caagtgtaga ttacattcac                                        30


<210>  333
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of C106B9 light chain CDR

<400>  333
agcacatcca tcctggcttc t                                                 21


<210>  334
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of C106B9 light chain CDR

<400>  334
cagcaaagga gtagttaccc acccacg                                           27


<210>  335
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of C106B9 light chain CDR

<400>  335

Ser Val Ser Ser Ser Val Asp Tyr Ile His 
1               5                   10  


<210>  336
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of C106B9 light chain CDR

<400>  336

Ser Thr Ser Ile Leu Ala Ser 
1               5           


<210>  337
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of C106B9 light chain CDR

<400>  337

Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  338
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of C106B9 heavy chain CDR

<400>  338
ggctactgga tagag                                                        15


<210>  339
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of C106B9 heavy chain CDR

<400>  339
gagattttac ctggaagtgg tggtactaac tacaatgaga aattcaaggg c                51


<210>  340
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of C106B9 heavy chain CDR

<400>  340
gatagtaact cctttactta c                                                 21


<210>  341
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of C106B9 heavy chain CDR

<400>  341

Gly Tyr Trp Ile Glu 
1               5   


<210>  342
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of C106B9 heavy chain CDR

<400>  342

Glu Ile Leu Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  343
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of C106B9 heavy chain CDR

<400>  343

Asp Ser Asn Ser Phe Thr Tyr 
1               5           


<210>  344
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of F184C7 light chain

<400>  344
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaatatttac agaaatttag catggtatca gcagaaacag      120

ggaaaatctc ctcaactcct ggtccatgct gcaacaaact tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc agacacacag tattccctca agatcaacag cctgcagtct      240

gaagattttg ggaattatta ctgtcaacat ttttggggga ctccgctcac gttcggtgct      300

gggaccaagc tggagctgaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         642


<210>  345
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of F184C7 light chain

<400>  345

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


His Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Asp Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  346
<211>  1338
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of F184C7 heavy chain

<400>  346
caggttcagc tgcagcagtc tggacctgag atggtgaagc ctggggcctc agtgaagatt       60

ccctgcaagg cttctggcta cgcattcagt agctcctgga tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacgg atttatcctg gagatggaga tactaactac      180

aatgagaagt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagtctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct acttctgtgc aagagaggct      300

actacggtag tggccccgta ctactttgac tactggggcc aaggcaccac tctcacagtc      360

tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa      420

actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca      480

gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag      540

tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg gcccagcgag      600

accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg      660

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      720

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      780

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      840

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      900

tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc      960

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc     1020

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat     1080

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg     1140

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat     1200

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat     1260

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc     1320

tcccactctc ctggtaaa                                                   1338


<210>  347
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of F184C7 heavy chain

<400>  347

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Met Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ala Thr Thr Val Val Ala Pro Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  348
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of F184C7 light chain CDR

<400>  348
cgagcaagtg agaatattta cagaaattta gca                                    33


<210>  349
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of F184C7 light chain CDR

<400>  349
gctgcaacaa acttagcaga t                                                 21


<210>  350
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of F184C7 light chain CDR

<400>  350
caacattttt gggggactcc gctcacg                                           27


<210>  351
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of F184C7 light chain CDR

<400>  351

Arg Ala Ser Glu Asn Ile Tyr Arg Asn Leu Ala 
1               5                   10      


<210>  352
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of F184C7 light chain CDR

<400>  352

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  353
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of F184C7 light chain CDR

<400>  353

Gln His Phe Trp Gly Thr Pro Leu Thr 
1               5                   


<210>  354
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of F184C7 heavy chain CDR

<400>  354
attcagtagc tcctggatga ac                                                22


<210>  355
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of F184C7 heavy chain CDR

<400>  355
cggatttatc ctggagatgg agatactaac tacaatgaga agttcaaggg c                51


<210>  356
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of F184C7 heavy chain CDR

<400>  356
gaggctacta cggtagtggc cccgtactac tttgactac                              39


<210>  357
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of F184C7 heavy chain CDR

<400>  357

Phe Ser Ser Ser Trp Met Asn 
1               5           


<210>  358
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of F184C7 heavy chain CDR

<400>  358

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  359
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of F184C7 heavy chain CDR

<400>  359

Glu Ala Thr Thr Val Val Ala Pro Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  360
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D10A3 light chain

<400>  360
aatattgtgc tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggtttcc       60

ataacctgca aggccagtca gcgtgtgaat aatgatgtag cttggtacca acagaagcca      120

gggcagtctc ctaaactgct gatatactat gcatccaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccattcac gttcggctcg      300

gggacaaagt tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         642


<210>  361
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D10A3 light chain

<400>  361

Asn Ile Val Leu Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Arg Val Asn Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  362
<211>  1332
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D10A3 heavy chain

<400>  362
gaggtccagc tgcaacagtt tggaactgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggcta cacattcact gactacaaca tggactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatccta actatgatac tactacctac      180

aaccagaagt tcaagggaaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac ttctgaggac actgcagtct tttactgtgc aagaaggaac      300

tatggtaact acgtggggtt tgacttctgg ggccaaggca ccactctcac agtctcctca      360

gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac      420

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc      480

tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac      540

ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc      600

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg      660

gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc      720

cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg      780

gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag      840

gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc      900

agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc      960

aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg     1020

aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc     1080

agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg     1140

aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct     1200

tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc     1260

acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac     1320

tctcctggta aa                                                         1332


<210>  363
<211>  444
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D10A3 heavy chain

<400>  363

Glu Val Gln Leu Gln Gln Phe Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Thr Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asn Tyr Gly Asn Tyr Val Gly Phe Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
    210                 215                 220                 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
    290                 295                 300                 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
305                 310                 315                 320 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
            340                 345                 350         


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
        355                 360                 365             


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
    370                 375                 380                 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
385                 390                 395                 400 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
                405                 410                 415     


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
            420                 425                 430         


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 


<210>  364
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D10A3 light chain CDR

<400>  364
aaggccagtc agcgtgtgaa taatgatgta gct                                    33


<210>  365
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D10A3 light chain CDR

<400>  365
tatgcatcca atcgctacac t                                                 21


<210>  366
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D10A3 light chain CDR

<400>  366
cagcaggatt atagctctcc attcacg                                           27


<210>  367
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D10A3 light chain CDR

<400>  367

Lys Ala Ser Gln Arg Val Asn Asn Asp Val Ala 
1               5                   10      


<210>  368
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D10A3 light chain CDR

<400>  368

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  369
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D10A3 light chain CDR

<400>  369

Gln Gln Asp Tyr Ser Ser Pro Phe Thr 
1               5                   


<210>  370
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D10A3 heavy chain CDR

<400>  370
gactacaaca tggac                                                        15


<210>  371
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D10A3 heavy chain CDR

<400>  371
gatattaatc ctaactatga tactactacc tacaaccaga agttcaaggg a                51


<210>  372
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic Acid sequence of D10A3 heavy chain CDR

<400>  372
aggaactatg gtaactacgt ggggtttgac ttc                                    33


<210>  373
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D10A3 heavy chain CDR

<400>  373

Asp Tyr Asn Met Asp 
1               5   


<210>  374
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D10A3 heavy chain CDR

<400>  374

Asp Ile Asn Pro Asn Tyr Asp Thr Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  375
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino Acid sequence of D10A3 heavy chain CDR

<400>  375

Arg Asn Tyr Gly Asn Tyr Val Gly Phe Asp Phe 
1               5                   10      


<210>  376
<211>  163
<212>  PRT
<213>  homo sapiens

<400>  376

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  377
<211>  164
<212>  PRT
<213>  homo sapiens

<400>  377

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  378
<211>  123
<212>  PRT
<213>  homo sapiens

<400>  378

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  379
<211>  101
<212>  PRT
<213>  homo sapiens

<400>  379

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  380
<211>  220
<212>  PRT
<213>  homo sapiens

<400>  380

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  381
<211>  255
<212>  PRT
<213>  homo sapiens

<400>  381

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  382
<211>  199
<212>  PRT
<213>  homo sapiens

<400>  382

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  383
<211>  277
<212>  PRT
<213>  homo sapiens

<400>  383

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  384
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short peptide

<400>  384

Asp Leu Met Gly Tyr Ile Pro Leu Val 
1               5                   


