                               SEQUENCE LISTING

<110> SCHWARZ, GUENTER
 
<120> METHODS AND COMPOSITIONS FOR TREATING METABOLIC DISORDERS 
      RESULTING IN SULFITE ACCUMULATION

<130> T 67389

<140>
<141>

<150> US 62/174,794
<151> 2015 06 12

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 1401
<212> DNA
<213> Homo sapiens

<400> 1
gagtcaacac acatatacac taaggaggaa gtgagttccc acaccagccc tgagactggg       60

atctgggtga ctctgggctc tgaggtcttt gatgtcacag aatttgtgga cctacatcca      120

ggggggcctt caaagctgat gctagcagct gggggtcccc tagagccctt ctgggccctc      180

tatgctgttc acaaccagtc ccatgtgcgt gagttactgg ctcagtacaa gattggggag      240

ctgaatcctg aagacaaggt agcccccacc gtggagacct ctgaccctta tgctgatgat      300

cctgtacgtc acccagccct gaaggtcaac agccagcggc cctttaatgc agagcctccc      360

cctgagctgc tgacagaaaa ctacatcaca cccaacccta tcttcttcac ccggaaccat      420

ctgcctgtac ctaacctgga tccagacacc tatcgcttac acgtagtagg agcacctggg      480

ggtcagtcac tgtctctttc cctggatgac ttgcacaact ttcccaggta cgagatcaca      540

gtcactctgc agtgtgccgg caaccgacgc tctgagatga ctcaggtcaa agaagtaaaa      600

ggtctggagt ggagaacagg agccatcagc actgcacgct gggctggggc acggctctgt      660

gatgtgttag cccaggctgg ccaccaactc tgtgaaactg aggcccacgt ctgctttgag      720

ggactggact cagaccctac tgggactgcc tatggagcat ccatccctct ggctcgggcc      780

atggaccctg aagctgaggt cctgctggca tatgagatga atgggcagcc tctgccacgt      840

gaccacggct tccctgtgcg tgtggtggtt cctggagtgg tgggtgcccg ccatgtcaaa      900

tggctgggca gagtgagtgt gcagccagag gaaagttaca gccactggca acggcgggat      960

tacaaaggct tctctccatc tgtggactgg gagactgtag attttgactc tgctccatcc     1020

attcaggaac ttcctgtcca gtccgccatc acagagcccc gggatggaga gactgtagaa     1080

tcaggggagg tgaccatcaa gggctatgca tggagtggtg gtggcagggc tgtgatccgg     1140

gtggatgtgt ctctggatgg gggcctaacc tggcaggtgg ctaagctgga tggagaggaa     1200

cagcgcccca ggaaggcctg ggcatggcgt ctgtggcagt tgaaagcccc tgtgccagct     1260

ggacaaaagg aactgaacat tgtttgtaag gctgtggatg atggttacaa tgtgcagcca     1320

gacaccgtgg ccccaatctg gaacctgcga ggtgttctca gcaatgcctg gcatcgtgtc     1380

catgtctatg tctccccatg a                                               1401


<210> 2
<211> 466
<212> PRT
<213> Homo sapiens

<400> 2
Glu Ser Thr His Ile Tyr Thr Lys Glu Glu Val Ser Ser His Thr Ser 
1               5                   10                  15      


Pro Glu Thr Gly Ile Trp Val Thr Leu Gly Ser Glu Val Phe Asp Val 
            20                  25                  30          


Thr Glu Phe Val Asp Leu His Pro Gly Gly Pro Ser Lys Leu Met Leu 
        35                  40                  45              


Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp Ala Leu Tyr Ala Val His 
    50                  55                  60                  


Asn Gln Ser His Val Arg Glu Leu Leu Ala Gln Tyr Lys Ile Gly Glu 
65                  70                  75                  80  


Leu Asn Pro Glu Asp Lys Val Ala Pro Thr Val Glu Thr Ser Asp Pro 
                85                  90                  95      


Tyr Ala Asp Asp Pro Val Arg His Pro Ala Leu Lys Val Asn Ser Gln 
            100                 105                 110         


Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu Leu Leu Thr Glu Asn Tyr 
        115                 120                 125             


Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg Asn His Leu Pro Val Pro 
    130                 135                 140                 


Asn Leu Asp Pro Asp Thr Tyr Arg Leu His Val Val Gly Ala Pro Gly 
145                 150                 155                 160 


Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp Leu His Asn Phe Pro Arg 
                165                 170                 175     


Tyr Glu Ile Thr Val Thr Leu Gln Cys Ala Gly Asn Arg Arg Ser Glu 
            180                 185                 190         


Met Thr Gln Val Lys Glu Val Lys Gly Leu Glu Trp Arg Thr Gly Ala 
        195                 200                 205             


Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg Leu Cys Asp Val Leu Ala 
    210                 215                 220                 


Gln Ala Gly His Gln Leu Cys Glu Thr Glu Ala His Val Cys Phe Glu 
225                 230                 235                 240 


Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala Tyr Gly Ala Ser Ile Pro 
                245                 250                 255     


Leu Ala Arg Ala Met Asp Pro Glu Ala Glu Val Leu Leu Ala Tyr Glu 
            260                 265                 270         


Met Asn Gly Gln Pro Leu Pro Arg Asp His Gly Phe Pro Val Arg Val 
        275                 280                 285             


Val Val Pro Gly Val Val Gly Ala Arg His Val Lys Trp Leu Gly Arg 
    290                 295                 300                 


Val Ser Val Gln Pro Glu Glu Ser Tyr Ser His Trp Gln Arg Arg Asp 
305                 310                 315                 320 


Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp Glu Thr Val Asp Phe Asp 
                325                 330                 335     


Ser Ala Pro Ser Ile Gln Glu Leu Pro Val Gln Ser Ala Ile Thr Glu 
            340                 345                 350         


Pro Arg Asp Gly Glu Thr Val Glu Ser Gly Glu Val Thr Ile Lys Gly 
        355                 360                 365             


Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val Ile Arg Val Asp Val Ser 
    370                 375                 380                 


Leu Asp Gly Gly Leu Thr Trp Gln Val Ala Lys Leu Asp Gly Glu Glu 
385                 390                 395                 400 


Gln Arg Pro Arg Lys Ala Trp Ala Trp Arg Leu Trp Gln Leu Lys Ala 
                405                 410                 415     


Pro Val Pro Ala Gly Gln Lys Glu Leu Asn Ile Val Cys Lys Ala Val 
            420                 425                 430         


Asp Asp Gly Tyr Asn Val Gln Pro Asp Thr Val Ala Pro Ile Trp Asn 
        435                 440                 445             


Leu Arg Gly Val Leu Ser Asn Ala Trp His Arg Val His Val Tyr Val 
    450                 455                 460                 


Ser Pro 
465     


<210> 3
<211> 1140
<212> DNA
<213> Homo sapiens

<400> 3
gcccccaccg tggagacctc tgacccttat gctgatgatc ctgtacgtca cccagccctg       60

aaggtcaaca gccagcggcc ctttaatgca gagcctcccc ctgagctgct gacagaaaac      120

tacatcacac ccaaccctat cttcttcacc cggaaccatc tgcctgtacc taacctggat      180

ccagacacct atcgcttaca cgtagtagga gcacctgggg gtcagtcact gtctctttcc      240

ctggatgact tgcacaactt tcccaggtac gagatcacag tcactctgca gtgtgccggc      300

aaccgacgct ctgagatgac tcaggtcaaa gaagtaaaag gtctggagtg gagaacagga      360

gccatcagca ctgcacgctg ggctggggca cggctctgtg atgtgttagc ccaggctggc      420

caccaactct gtgaaactga ggcccacgtc tgctttgagg gactggactc agaccctact      480

gggactgcct atggagcatc catccctctg gctcgggcca tggaccctga agctgaggtc      540

ctgctggcat atgagatgaa tgggcagcct ctgccacgtg accacggctt ccctgtgcgt      600

gtggtggttc ctggagtggt gggtgcccgc catgtcaaat ggctgggcag agtgagtgtg      660

cagccagagg aaagttacag ccactggcaa cggcgggatt acaaaggctt ctctccatct      720

gtggactggg agactgtaga ttttgactct gctccatcca ttcaggaact tcctgtccag      780

tccgccatca cagagccccg ggatggagag actgtagaat caggggaggt gaccatcaag      840

ggctatgcat ggagtggtgg tggcagggct gtgatccggg tggatgtgtc tctggatggg      900

ggcctaacct ggcaggtggc taagctggat ggagaggaac agcgccccag gaaggcctgg      960

gcatggcgtc tgtggcagtt gaaagcccct gtgccagctg gacaaaagga actgaacatt     1020

gtttgtaagg ctgtggatga tggttacaat gtgcagccag acaccgtggc cccaatctgg     1080

aacctgcgag gtgttctcag caatgcctgg catcgtgtcc atgtctatgt ctccccatga     1140


<210> 4
<211> 379
<212> PRT
<213> Homo sapiens

<400> 4
Ala Pro Thr Val Glu Thr Ser Asp Pro Tyr Ala Asp Asp Pro Val Arg 
1               5                   10                  15      


His Pro Ala Leu Lys Val Asn Ser Gln Arg Pro Phe Asn Ala Glu Pro 
            20                  25                  30          


Pro Pro Glu Leu Leu Thr Glu Asn Tyr Ile Thr Pro Asn Pro Ile Phe 
        35                  40                  45              


Phe Thr Arg Asn His Leu Pro Val Pro Asn Leu Asp Pro Asp Thr Tyr 
    50                  55                  60                  


Arg Leu His Val Val Gly Ala Pro Gly Gly Gln Ser Leu Ser Leu Ser 
65                  70                  75                  80  


Leu Asp Asp Leu His Asn Phe Pro Arg Tyr Glu Ile Thr Val Thr Leu 
                85                  90                  95      


Gln Cys Ala Gly Asn Arg Arg Ser Glu Met Thr Gln Val Lys Glu Val 
            100                 105                 110         


Lys Gly Leu Glu Trp Arg Thr Gly Ala Ile Ser Thr Ala Arg Trp Ala 
        115                 120                 125             


Gly Ala Arg Leu Cys Asp Val Leu Ala Gln Ala Gly His Gln Leu Cys 
    130                 135                 140                 


Glu Thr Glu Ala His Val Cys Phe Glu Gly Leu Asp Ser Asp Pro Thr 
145                 150                 155                 160 


Gly Thr Ala Tyr Gly Ala Ser Ile Pro Leu Ala Arg Ala Met Asp Pro 
                165                 170                 175     


Glu Ala Glu Val Leu Leu Ala Tyr Glu Met Asn Gly Gln Pro Leu Pro 
            180                 185                 190         


Arg Asp His Gly Phe Pro Val Arg Val Val Val Pro Gly Val Val Gly 
        195                 200                 205             


Ala Arg His Val Lys Trp Leu Gly Arg Val Ser Val Gln Pro Glu Glu 
    210                 215                 220                 


Ser Tyr Ser His Trp Gln Arg Arg Asp Tyr Lys Gly Phe Ser Pro Ser 
225                 230                 235                 240 


Val Asp Trp Glu Thr Val Asp Phe Asp Ser Ala Pro Ser Ile Gln Glu 
                245                 250                 255     


Leu Pro Val Gln Ser Ala Ile Thr Glu Pro Arg Asp Gly Glu Thr Val 
            260                 265                 270         


Glu Ser Gly Glu Val Thr Ile Lys Gly Tyr Ala Trp Ser Gly Gly Gly 
        275                 280                 285             


Arg Ala Val Ile Arg Val Asp Val Ser Leu Asp Gly Gly Leu Thr Trp 
    290                 295                 300                 


Gln Val Ala Lys Leu Asp Gly Glu Glu Gln Arg Pro Arg Lys Ala Trp 
305                 310                 315                 320 


Ala Trp Arg Leu Trp Gln Leu Lys Ala Pro Val Pro Ala Gly Gln Lys 
                325                 330                 335     


Glu Leu Asn Ile Val Cys Lys Ala Val Asp Asp Gly Tyr Asn Val Gln 
            340                 345                 350         


Pro Asp Thr Val Ala Pro Ile Trp Asn Leu Arg Gly Val Leu Ser Asn 
        355                 360                 365             


Ala Trp His Arg Val His Val Tyr Val Ser Pro 
    370                 375                 


<210> 5
<211> 1584
<212> DNA
<213> Homo sapiens

<400> 5
atggctgaca gccgggatcc cgccagcgac cagatgcagc actggaagga gcagcgggcc       60

gcgcagaaag ctgatgtcct gaccactgga gctggtaacc cagtaggaga caaacttaat      120

gttattacag tagggccccg tgggcccctt cttgttcagg atgtggtttt cactgatgaa      180

atggctcatt ttgaccgaga gagaattcct gagagagttg tgcatgctaa aggagcaggg      240

gcctttggct actttgaggt cacacatgac attaccaaat actccaaggc aaaggtattt      300

gagcatattg gaaagaagac tcccatcgca gttcggttct ccactgttgc tggagaatcg      360

ggttcagctg acacagttcg ggaccctcgt gggtttgcag tgaaatttta cacagaagat      420

ggtaactggg atctcgttgg aaataacacc cccattttct tcatcaggga tcccatattg      480

tttccatctt ttatccacag ccaaaagaga aatcctcaga cacatctgaa ggatccggac      540

atggtctggg acttctggag cctacgtcct gagtctctgc atcaggtttc tttcttgttc      600

agtgatcggg ggattccaga tggacatcgc cacatgaatg gatatggatc acatactttc      660

aagctggtta atgcaaatgg ggaggcagtt tattgcaaat tccattataa gactgaccag      720

ggcatcaaaa acctttctgt tgaagatgcg gcgagacttt cccaggaaga tcctgactat      780

ggcatccggg atctttttaa cgccattgcc acaggaaagt acccctcctg gactttttac      840

atccaggtca tgacatttaa tcaggcagaa acttttccat ttaatccatt cgatctcacc      900

aaggtttggc ctcacaagga ctaccctctc atcccagttg gtaaactggt cttaaaccgg      960

aatccagtta attactttgc tgaggttgaa cagatagcct tcgacccaag caacatgcca     1020

cctggcattg aggccagtcc tgacaaaatg cttcagggcc gcctttttgc ctatcctgac     1080

actcaccgcc atcgcctggg acccaattat cttcatatac ctgtgaactg tccctaccgt     1140

gctcgagtgg ccaactacca gcgtgacggc ccgatgtgca tgcaggacaa tcagggtggt     1200

gctccaaatt actaccccaa cagctttggt gctccggaac aacagccttc tgccctggag     1260

cacagcatcc aatattctgg agaagtgcgg agattcaaca ctgccaatga tgataacgtt     1320

actcaggtgc gggcattcta tgtgaacgtg ctgaatgagg aacagaggaa acgtctgtgt     1380

gagaacattg ccggccacct gaaggatgca caaattttca tccagaagaa agcggtcaag     1440

aacttcactg aggtccaccc tgactacggg agccacatcc aggctcttct ggacaagtac     1500

aatgctgaga agcctaagaa tgcgattcac acctttgtgc agtccggatc tcacttggcg     1560

gcaagggaga aggcaaatct gtga                                            1584


<210> 6
<211> 527
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 7
His His His His His His 
1               5       


<210> 8
<211> 1467
<212> DNA
<213> Homo sapiens

<400> 8
atggggaccc tattaggtct cggtgcagtg ttggcctatc aggaccatcg gtgtagggct       60

gctcaggagt caacacacat atacactaag gaggaagtga gttcccacac cagccctgag      120

actgggatct gggtgactct gggctctgag gtctttgatg tcacagaatt tgtggaccta      180

catccagggg ggccttcaaa gctgatgcta gcagctgggg gtcccctaga gcccttctgg      240

gccctctatg ctgttcacaa ccagtcccat gtgcgtgagt tactggctca gtacaagatt      300

ggggagctga atcctgaaga caaggtagcc cccaccgtgg agacctctga cccttatgct      360

gatgatcctg tacgtcaccc agccctgaag gtcaacagcc agcggccctt taatgcagag      420

cctccccctg agctgctgac agaaaactac atcacaccca accctatctt cttcacccgg      480

aaccatctgc ctgtacctaa cctggatcca gacacctatc gcttacacgt agtaggagca      540

cctgggggtc agtcactgtc tctttccctg gatgacttgc acaactttcc caggtacgag      600

atcacagtca ctctgcagtg tgccggcaac cgacgctctg agatgactca ggtcaaagaa      660

gtaaaaggtc tggagtggag aacaggagcc atcagcactg cacgctgggc tggggcacgg      720

ctctgtgatg tgttagccca ggctggccac caactctgtg aaactgaggc ccacgtctgc      780

tttgagggac tggactcaga ccctactggg actgcctatg gagcatccat ccctctggct      840

cgggccatgg accctgaagc tgaggtcctg ctggcatatg agatgaatgg gcagcctctg      900

ccacgtgacc acggcttccc tgtgcgtgtg gtggttcctg gagtggtggg tgcccgccat      960

gtcaaatggc tgggcagagt gagtgtgcag ccagaggaaa gttacagcca ctggcaacgg     1020

cgggattaca aaggcttctc tccatctgtg gactgggaga ctgtagattt tgactctgct     1080

ccatccattc aggaacttcc tgtccagtcc gccatcacag agccccggga tggagagact     1140

gtagaatcag gggaggtgac catcaagggc tatgcatgga gtggtggtgg cagggctgtg     1200

atccgggtgg atgtgtctct ggatgggggc ctaacctggc aggtggctaa gctggatgga     1260

gaggaacagc gccccaggaa ggcctgggca tggcgtctgt ggcagttgaa agcccctgtg     1320

ccagctggac aaaaggaact gaacattgtt tgtaaggctg tggatgatgg ttacaatgtg     1380

cagccagaca ccgtggcccc aatctggaac ctgcgaggtg ttctcagcaa tgcctggcat     1440

cgtgtccatg tctatgtctc cccatga                                         1467


<210> 9
<211> 488
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Thr Leu Leu Gly Leu Gly Ala Val Leu Ala Tyr Gln Asp His 
1               5                   10                  15      


Arg Cys Arg Ala Ala Gln Glu Ser Thr His Ile Tyr Thr Lys Glu Glu 
            20                  25                  30          


Val Ser Ser His Thr Ser Pro Glu Thr Gly Ile Trp Val Thr Leu Gly 
        35                  40                  45              


Ser Glu Val Phe Asp Val Thr Glu Phe Val Asp Leu His Pro Gly Gly 
    50                  55                  60                  


Pro Ser Lys Leu Met Leu Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp 
65                  70                  75                  80  


Ala Leu Tyr Ala Val His Asn Gln Ser His Val Arg Glu Leu Leu Ala 
                85                  90                  95      


Gln Tyr Lys Ile Gly Glu Leu Asn Pro Glu Asp Lys Val Ala Pro Thr 
            100                 105                 110         


Val Glu Thr Ser Asp Pro Tyr Ala Asp Asp Pro Val Arg His Pro Ala 
        115                 120                 125             


Leu Lys Val Asn Ser Gln Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu 
    130                 135                 140                 


Leu Leu Thr Glu Asn Tyr Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg 
145                 150                 155                 160 


Asn His Leu Pro Val Pro Asn Leu Asp Pro Asp Thr Tyr Arg Leu His 
                165                 170                 175     


Val Val Gly Ala Pro Gly Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp 
            180                 185                 190         


Leu His Asn Phe Pro Arg Tyr Glu Ile Thr Val Thr Leu Gln Cys Ala 
        195                 200                 205             


Gly Asn Arg Arg Ser Glu Met Thr Gln Val Lys Glu Val Lys Gly Leu 
    210                 215                 220                 


Glu Trp Arg Thr Gly Ala Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg 
225                 230                 235                 240 


Leu Cys Asp Val Leu Ala Gln Ala Gly His Gln Leu Cys Glu Thr Glu 
                245                 250                 255     


Ala His Val Cys Phe Glu Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala 
            260                 265                 270         


Tyr Gly Ala Ser Ile Pro Leu Ala Arg Ala Met Asp Pro Glu Ala Glu 
        275                 280                 285             


Val Leu Leu Ala Tyr Glu Met Asn Gly Gln Pro Leu Pro Arg Asp His 
    290                 295                 300                 


Gly Phe Pro Val Arg Val Val Val Pro Gly Val Val Gly Ala Arg His 
305                 310                 315                 320 


Val Lys Trp Leu Gly Arg Val Ser Val Gln Pro Glu Glu Ser Tyr Ser 
                325                 330                 335     


His Trp Gln Arg Arg Asp Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp 
            340                 345                 350         


Glu Thr Val Asp Phe Asp Ser Ala Pro Ser Ile Gln Glu Leu Pro Val 
        355                 360                 365             


Gln Ser Ala Ile Thr Glu Pro Arg Asp Gly Glu Thr Val Glu Ser Gly 
    370                 375                 380                 


Glu Val Thr Ile Lys Gly Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val 
385                 390                 395                 400 


Ile Arg Val Asp Val Ser Leu Asp Gly Gly Leu Thr Trp Gln Val Ala 
                405                 410                 415     


Lys Leu Asp Gly Glu Glu Gln Arg Pro Arg Lys Ala Trp Ala Trp Arg 
            420                 425                 430         


Leu Trp Gln Leu Lys Ala Pro Val Pro Ala Gly Gln Lys Glu Leu Asn 
        435                 440                 445             


Ile Val Cys Lys Ala Val Asp Asp Gly Tyr Asn Val Gln Pro Asp Thr 
    450                 455                 460                 


Val Ala Pro Ile Trp Asn Leu Arg Gly Val Leu Ser Asn Ala Trp His 
465                 470                 475                 480 


Arg Val His Val Tyr Val Ser Pro 
                485             


<210> 10
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Gly Thr Leu Leu Gly Leu Gly Ala Val Leu Ala Tyr Gln Asp His 
1               5                   10                  15      


Arg Cys Arg Ala Ala Gln Glu Ser Thr His Ile Tyr Thr Lys Glu Glu 
            20                  25                  30          


Val Ser Ser His Thr Ser Pro Glu Thr Gly Ile Trp Val Thr Leu Gly 
        35                  40                  45              


Ser Glu Val Phe Asp Val Thr Glu Phe Val Asp Leu His Pro Gly Gly 
    50                  55                  60                  


Pro Ser Lys Leu Met Leu Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp 
65                  70                  75                  80  


Ala Leu Tyr Ala Val His Asn Gln Ser His Val Arg Glu Leu Leu Ala 
                85                  90                  95      


Gln Tyr Lys Ile Gly Glu Leu Asn Pro Glu Asp Pro Glu Thr Ser Asp 
            100                 105                 110         


Pro Tyr Ala Asp Asp Pro Val Arg His Pro Ala Leu Lys Val Asn Ser 
        115                 120                 125             


Gln Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu Leu Leu Thr Glu Asn 
    130                 135                 140                 


Tyr Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg Asn His Leu Pro Val 
145                 150                 155                 160 


Pro Asn Leu Asp Pro Asp Thr Tyr Arg Leu His Val Val Gly Ala Pro 
                165                 170                 175     


Gly Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp Leu His Asn Phe Pro 
            180                 185                 190         


Arg Tyr Glu Ile Thr Val Thr Leu Gln Cys Ala Gly Asn Arg Arg Ser 
        195                 200                 205             


Glu Met Thr Gln Val Lys Glu Val Lys Gly Leu Glu Trp Arg Thr Gly 
    210                 215                 220                 


Ala Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg Leu Cys Asp Val Leu 
225                 230                 235                 240 


Ala Gln Ala Gly His Gln Leu Cys Glu Thr Glu Ala His Val Cys Phe 
                245                 250                 255     


Glu Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala Tyr Gly Ala Ser Ile 
            260                 265                 270         


Pro Leu Ala Arg Ala Met Asp Pro Glu Ala Glu Val Leu Leu Ala Tyr 
        275                 280                 285             


Glu Met Asn Gly Gln Pro Leu Pro Arg Asp His Gly Phe Pro Val Arg 
    290                 295                 300                 


Val Val Val Pro Gly Val Val Gly Ala Arg His Val Lys Trp Leu Gly 
305                 310                 315                 320 


Arg Val Ser Val Gln Pro Glu Glu Ser Tyr Ser His Trp Gln Arg Arg 
                325                 330                 335     


Asp Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp Glu Thr Val Asp Phe 
            340                 345                 350         


Asp Ser Ala Pro Ser Ile Gln Glu Leu Pro Val Gln Ser Ala Ile Thr 
        355                 360                 365             


Glu Pro Arg Asp Gly Glu Thr Val Glu Ser Gly Glu Val Thr Ile Lys 
    370                 375                 380                 


Gly Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val Ile Arg Val Asp Val 
385                 390                 395                 400 


Ser Leu Asp Gly Gly Leu Thr Trp Gln Val Ala Lys Leu Asp Gly Glu 
                405                 410                 415     


Glu Gln Arg Pro Arg Lys Ala Trp Ala Trp Arg Leu Trp Gln Leu Lys 
            420                 425                 430         


Ala Pro Val Pro Ala Gly Gln Lys Glu Leu Asn Ile Val Cys Lys Ala 
        435                 440                 445             


Val Asp Asp Gly Tyr Asn Val Gln Pro Asp Thr Val Ala Pro Ile Trp 
    450                 455                 460                 


Asn Leu Arg Gly Val Leu Ser Asn Ala Trp His Arg Val His Val Tyr 
465                 470                 475                 480 


Val Ser Pro 
            


<210> 11
<211> 482
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Gly Thr Leu Leu Gly Leu Gly Ala Val Leu Ala Tyr Gln Asp His 
1               5                   10                  15      


Arg Cys Arg Ala Ala Gln Glu Ser Thr His Ile Tyr Thr Lys Glu Glu 
            20                  25                  30          


Val Ser Ser His Thr Ser Pro Glu Thr Gly Ile Trp Val Thr Leu Gly 
        35                  40                  45              


Ser Glu Val Phe Asp Val Thr Glu Phe Val Asp Leu His Pro Gly Gly 
    50                  55                  60                  


Pro Ser Lys Leu Met Leu Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp 
65                  70                  75                  80  


Ala Leu Tyr Ala Val His Asn Gln Ser His Val Arg Glu Leu Leu Ala 
                85                  90                  95      


Gln Tyr Lys Ile Gly Glu Leu Asn Pro Glu Asp Glu Thr Ser Asp Pro 
            100                 105                 110         


Tyr Ala Asp Asp Pro Val Arg His Pro Ala Leu Lys Val Asn Ser Gln 
        115                 120                 125             


Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu Leu Leu Thr Glu Asn Tyr 
    130                 135                 140                 


Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg Asn His Leu Pro Val Pro 
145                 150                 155                 160 


Asn Leu Asp Pro Asp Thr Tyr Arg Leu His Val Val Gly Ala Pro Gly 
                165                 170                 175     


Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp Leu His Asn Phe Pro Arg 
            180                 185                 190         


Tyr Glu Ile Thr Val Thr Leu Gln Cys Ala Gly Asn Arg Arg Ser Glu 
        195                 200                 205             


Met Thr Gln Val Lys Glu Val Lys Gly Leu Glu Trp Arg Thr Gly Ala 
    210                 215                 220                 


Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg Leu Cys Asp Val Leu Ala 
225                 230                 235                 240 


Gln Ala Gly His Gln Leu Cys Glu Thr Glu Ala His Val Cys Phe Glu 
                245                 250                 255     


Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala Tyr Gly Ala Ser Ile Pro 
            260                 265                 270         


Leu Ala Arg Ala Met Asp Pro Glu Ala Glu Val Leu Leu Ala Tyr Glu 
        275                 280                 285             


Met Asn Gly Gln Pro Leu Pro Arg Asp His Gly Phe Pro Val Arg Val 
    290                 295                 300                 


Val Val Pro Gly Val Val Gly Ala Arg His Val Lys Trp Leu Gly Arg 
305                 310                 315                 320 


Val Ser Val Gln Pro Glu Glu Ser Tyr Ser His Trp Gln Arg Arg Asp 
                325                 330                 335     


Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp Glu Thr Val Asp Phe Asp 
            340                 345                 350         


Ser Ala Pro Ser Ile Gln Glu Leu Pro Val Gln Ser Ala Ile Thr Glu 
        355                 360                 365             


Pro Arg Asp Gly Glu Thr Val Glu Ser Gly Glu Val Thr Ile Lys Gly 
    370                 375                 380                 


Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val Ile Arg Val Asp Val Ser 
385                 390                 395                 400 


Leu Asp Gly Gly Leu Thr Trp Gln Val Ala Lys Leu Asp Gly Glu Glu 
                405                 410                 415     


Gln Arg Pro Arg Lys Ala Trp Ala Trp Arg Leu Trp Gln Leu Lys Ala 
            420                 425                 430         


Pro Val Pro Ala Gly Gln Lys Glu Leu Asn Ile Val Cys Lys Ala Val 
        435                 440                 445             


Asp Asp Gly Tyr Asn Val Gln Pro Asp Thr Val Ala Pro Ile Trp Asn 
    450                 455                 460                 


Leu Arg Gly Val Leu Ser Asn Ala Trp His Arg Val His Val Tyr Val 
465                 470                 475                 480 


Ser Pro 
        


<210> 12
<211> 1641
<212> DNA
<213> Mus musculus

<400> 12
atgctgctgc agctatacag atccgtggtt gtgaggcttc cacaggccat cagagtcaag       60

tcaaccccct tgaggctctg cattcaagca tgctccacaa atgattcact tgagccccag      120

catcccagcc ttaccttttc tgatgataac tcaaggactc ggagatggaa agtcatgggg      180

accctgttag gcctgggtgt ggtgctggtc taccatgagc atcggtgtag ggcttctcag      240

gagtcaccac ggatgtactc taaagaggat gtgcgttctc acaacaaccc taaaactgga      300

gtctgggtaa ctctaggctc tgaggtcttc gatgtcacaa aatttgtgga cctgcatcca      360

ggaggaccat caaaactgat gctagcagct ggaggtcccc tagaaccctt ctgggccctc      420

tatgctgtgc acaaccagcc ccatgtacgt gagttactgg ccgagtataa gattggggaa      480

ctgaaccccg aagatagcat gtccccctcc gtggaagcct ctgaccctta tgctgatgat      540

cctattcgtc atccagccct gaggattaat agccagcgcc cctttaatgc agagcctcct      600

cctgaactgc taactgaagg ctacatcaca ccaaatccta ttttcttcac ccgtaaccat      660

ctgcctgtac ctaacctgga cccacacacc tatcgcttac atgtagtagg ggcacctgga      720

ggtcagtcac tgtctctgtc cttggatgat ttgcataagt ttcccaaaca tgaggtcact      780

gtcactctgc agtgtgctgg taaccggcgc tccgaaatga gtaaggtcaa ggaagtgaaa      840

ggtctggaat ggagaacagg ggccatcagc acagcacgct gggctggggc ccggctctgt      900

gatgtgttag cccaggctgg tcaccgactc tgtgactctg aggcccatgt ctgttttgaa      960

ggactggatt cagaccccac tggaactgcc tatggagcat cgatccctct ggctcgggcc     1020

atggatcctg aagccgaggt cctcctggct tatgaaatga atggtcagcc tctacctcgt     1080

gaccatggct tccctgtacg ggtggtggtt cctggtgtag taggtgcccg tcatgtcaaa     1140

tggctcggca gagtgagtgt ggaatcagag gagagttata gtcactggca gaggcgggat     1200

tacaaaggct tttctccatc tgtggactgg gacacggtaa actttgacct agctccatca     1260

attcaggaac tacctatcca gtcagctatc acacaacctc aagatggggc cattgtagag     1320

tcaggcgagg tgactatcaa gggctatgca tggagtggtg gtggcagggc tgtgattcga     1380

gtggatgtgt ctgtggatgg gggactaacc tggcaggaag ctgagctaga gggagaggaa     1440

cagtgtccca ggaaggcctg ggcttggcga atatggcagt tgaaagctca ggtgccggct     1500

gagcaaaagg aattgaacat catttgcaaa gctgtagatg acagttacaa tgtgcagcca     1560

gacactgtag ccccaatctg gaaccttcgg ggcgtactca gcaatgcctg gcaccgtgtc     1620

catgttcagg tggtcccatg a                                               1641


<210> 13
<211> 546
<212> PRT
<213> Mus musculus

<400> 13
Met Leu Leu Gln Leu Tyr Arg Ser Val Val Val Arg Leu Pro Gln Ala 
1               5                   10                  15      


Ile Arg Val Lys Ser Thr Pro Leu Arg Leu Cys Ile Gln Ala Cys Ser 
            20                  25                  30          


Thr Asn Asp Ser Leu Glu Pro Gln His Pro Ser Leu Thr Phe Ser Asp 
        35                  40                  45              


Asp Asn Ser Arg Thr Arg Arg Trp Lys Val Met Gly Thr Leu Leu Gly 
    50                  55                  60                  


Leu Gly Val Val Leu Val Tyr His Glu His Arg Cys Arg Ala Ser Gln 
65                  70                  75                  80  


Glu Ser Pro Arg Met Tyr Ser Lys Glu Asp Val Arg Ser His Asn Asn 
                85                  90                  95      


Pro Lys Thr Gly Val Trp Val Thr Leu Gly Ser Glu Val Phe Asp Val 
            100                 105                 110         


Thr Lys Phe Val Asp Leu His Pro Gly Gly Pro Ser Lys Leu Met Leu 
        115                 120                 125             


Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp Ala Leu Tyr Ala Val His 
    130                 135                 140                 


Asn Gln Pro His Val Arg Glu Leu Leu Ala Glu Tyr Lys Ile Gly Glu 
145                 150                 155                 160 


Leu Asn Pro Glu Asp Ser Met Ser Pro Ser Val Glu Ala Ser Asp Pro 
                165                 170                 175     


Tyr Ala Asp Asp Pro Ile Arg His Pro Ala Leu Arg Ile Asn Ser Gln 
            180                 185                 190         


Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu Leu Leu Thr Glu Gly Tyr 
        195                 200                 205             


Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg Asn His Leu Pro Val Pro 
    210                 215                 220                 


Asn Leu Asp Pro His Thr Tyr Arg Leu His Val Val Gly Ala Pro Gly 
225                 230                 235                 240 


Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp Leu His Lys Phe Pro Lys 
                245                 250                 255     


His Glu Val Thr Val Thr Leu Gln Cys Ala Gly Asn Arg Arg Ser Glu 
            260                 265                 270         


Met Ser Lys Val Lys Glu Val Lys Gly Leu Glu Trp Arg Thr Gly Ala 
        275                 280                 285             


Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg Leu Cys Asp Val Leu Ala 
    290                 295                 300                 


Gln Ala Gly His Arg Leu Cys Asp Ser Glu Ala His Val Cys Phe Glu 
305                 310                 315                 320 


Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala Tyr Gly Ala Ser Ile Pro 
                325                 330                 335     


Leu Ala Arg Ala Met Asp Pro Glu Ala Glu Val Leu Leu Ala Tyr Glu 
            340                 345                 350         


Met Asn Gly Gln Pro Leu Pro Arg Asp His Gly Phe Pro Val Arg Val 
        355                 360                 365             


Val Val Pro Gly Val Val Gly Ala Arg His Val Lys Trp Leu Gly Arg 
    370                 375                 380                 


Val Ser Val Glu Ser Glu Glu Ser Tyr Ser His Trp Gln Arg Arg Asp 
385                 390                 395                 400 


Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp Asp Thr Val Asn Phe Asp 
                405                 410                 415     


Leu Ala Pro Ser Ile Gln Glu Leu Pro Ile Gln Ser Ala Ile Thr Gln 
            420                 425                 430         


Pro Gln Asp Gly Ala Ile Val Glu Ser Gly Glu Val Thr Ile Lys Gly 
        435                 440                 445             


Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val Ile Arg Val Asp Val Ser 
    450                 455                 460                 


Val Asp Gly Gly Leu Thr Trp Gln Glu Ala Glu Leu Glu Gly Glu Glu 
465                 470                 475                 480 


Gln Cys Pro Arg Lys Ala Trp Ala Trp Arg Ile Trp Gln Leu Lys Ala 
                485                 490                 495     


Gln Val Pro Ala Glu Gln Lys Glu Leu Asn Ile Ile Cys Lys Ala Val 
            500                 505                 510         


Asp Asp Ser Tyr Asn Val Gln Pro Asp Thr Val Ala Pro Ile Trp Asn 
        515                 520                 525             


Leu Arg Gly Val Leu Ser Asn Ala Trp His Arg Val His Val Gln Val 
    530                 535                 540                 


Val Pro 
545     


<210> 14
<211> 546
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Leu Leu Gln Leu Tyr Arg Ser Val Val Val Arg Leu Pro Gln Ala 
1               5                   10                  15      


Ile Arg Val Lys Ser Thr Pro Leu Arg Leu Cys Ile Gln Ala Cys Ser 
            20                  25                  30          


Thr Asn Asp Ser Leu Glu Pro Gln His Pro Ser Leu Thr Phe Ser Asp 
        35                  40                  45              


Asp Asn Ser Arg Thr Arg Arg Trp Lys Val Met Gly Thr Leu Leu Gly 
    50                  55                  60                  


Leu Gly Val Val Leu Val Tyr His Glu His Arg Cys Arg Ala Ser Gln 
65                  70                  75                  80  


Glu Ser Pro Arg Met Tyr Ser Lys Glu Asp Val Arg Ser His Asn Asn 
                85                  90                  95      


Pro Lys Thr Gly Val Trp Val Thr Leu Gly Ser Glu Val Phe Asp Val 
            100                 105                 110         


Thr Lys Phe Val Asp Leu Ala Pro Gly Gly Pro Ser Lys Leu Met Leu 
        115                 120                 125             


Ala Ala Gly Gly Pro Leu Glu Pro Phe Trp Ala Leu Tyr Ala Val Ala 
    130                 135                 140                 


Asn Gln Pro His Val Arg Glu Leu Leu Ala Glu Tyr Lys Ile Gly Glu 
145                 150                 155                 160 


Leu Asn Pro Glu Asp Ser Met Ser Pro Ser Val Glu Ala Ser Asp Pro 
                165                 170                 175     


Tyr Ala Asp Asp Pro Ile Arg His Pro Ala Leu Arg Ile Asn Ser Gln 
            180                 185                 190         


Arg Pro Phe Asn Ala Glu Pro Pro Pro Glu Leu Leu Thr Glu Gly Tyr 
        195                 200                 205             


Ile Thr Pro Asn Pro Ile Phe Phe Thr Arg Asn His Leu Pro Val Pro 
    210                 215                 220                 


Asn Leu Asp Pro His Thr Tyr Arg Leu His Val Val Gly Ala Pro Gly 
225                 230                 235                 240 


Gly Gln Ser Leu Ser Leu Ser Leu Asp Asp Leu His Lys Phe Pro Lys 
                245                 250                 255     


His Glu Val Thr Val Thr Leu Gln Cys Ala Gly Asn Arg Arg Ser Glu 
            260                 265                 270         


Met Ser Lys Val Lys Glu Val Lys Gly Leu Glu Trp Arg Thr Gly Ala 
        275                 280                 285             


Ile Ser Thr Ala Arg Trp Ala Gly Ala Arg Leu Cys Asp Val Leu Ala 
    290                 295                 300                 


Gln Ala Gly His Arg Leu Cys Asp Ser Glu Ala His Val Cys Phe Glu 
305                 310                 315                 320 


Gly Leu Asp Ser Asp Pro Thr Gly Thr Ala Tyr Gly Ala Ser Ile Pro 
                325                 330                 335     


Leu Ala Arg Ala Met Asp Pro Glu Ala Glu Val Leu Leu Ala Tyr Glu 
            340                 345                 350         


Met Asn Gly Gln Pro Leu Pro Arg Asp His Gly Phe Pro Val Arg Val 
        355                 360                 365             


Val Val Pro Gly Val Val Gly Ala Arg His Val Lys Trp Leu Gly Arg 
    370                 375                 380                 


Val Ser Val Glu Ser Glu Glu Ser Tyr Ser His Trp Gln Arg Arg Asp 
385                 390                 395                 400 


Tyr Lys Gly Phe Ser Pro Ser Val Asp Trp Asp Thr Val Asn Phe Asp 
                405                 410                 415     


Leu Ala Pro Ser Ile Gln Glu Leu Pro Ile Gln Ser Ala Ile Thr Gln 
            420                 425                 430         


Pro Gln Asp Gly Ala Ile Val Glu Ser Gly Glu Val Thr Ile Lys Gly 
        435                 440                 445             


Tyr Ala Trp Ser Gly Gly Gly Arg Ala Val Ile Arg Val Asp Val Ser 
    450                 455                 460                 


Val Asp Gly Gly Leu Thr Trp Gln Glu Ala Glu Leu Glu Gly Glu Glu 
465                 470                 475                 480 


Gln Cys Pro Arg Lys Ala Trp Ala Trp Arg Ile Trp Gln Leu Lys Ala 
                485                 490                 495     


Gln Val Pro Ala Glu Gln Lys Glu Leu Asn Ile Ile Cys Lys Ala Val 
            500                 505                 510         


Asp Asp Ser Tyr Asn Val Gln Pro Asp Thr Val Ala Pro Ile Trp Asn 
        515                 520                 525             


Leu Arg Gly Val Leu Ser Asn Ala Trp His Arg Val His Val Gln Val 
    530                 535                 540                 


Val Pro 
545     


<210> 15
<211> 1140
<212> DNA
<213> Mus musculus

<400> 15
tccccctccg tggaagcctc tgacccttat gctgatgatc ctattcgtca tccagccctg       60

aggattaata gccagcgccc ctttaatgca gagcctcctc ctgaactgct aactgaaggc      120

tacatcacac caaatcctat tttcttcacc cgtaaccatc tgcctgtacc taacctggac      180

ccacacacct atcgcttaca tgtagtaggg gcacctggag gtcagtcact gtctctgtcc      240

ttggatgatt tgcataagtt tcccaaacat gaggtcactg tcactctgca gtgtgctggt      300

aaccggcgct ccgaaatgag taaggtcaag gaagtgaaag gtctggaatg gagaacaggg      360

gccatcagca cagcacgctg ggctggggcc cggctctgtg atgtgttagc ccaggctggt      420

caccgactct gtgactctga ggcccatgtc tgttttgaag gactggattc agaccccact      480

ggaactgcct atggagcatc gatccctctg gctcgggcca tggatcctga agccgaggtc      540

ctcctggctt atgaaatgaa tggtcagcct ctacctcgtg accatggctt ccctgtacgg      600

gtggtggttc ctggtgtagt aggtgcccgt catgtcaaat ggctcggcag agtgagtgtg      660

gaatcagagg agagttatag tcactggcag aggcgggatt acaaaggctt ttctccatct      720

gtggactggg acacggtaaa ctttgaccta gctccatcaa ttcaggaact acctatccag      780

tcagctatca cacaacctca agatggggcc attgtagagt caggcgaggt gactatcaag      840

ggctatgcat ggagtggtgg tggcagggct gtgattcgag tggatgtgtc tgtggatggg      900

ggactaacct ggcaggaagc tgagctagag ggagaggaac agtgtcccag gaaggcctgg      960

gcttggcgaa tatggcagtt gaaagctcag gtgccggctg agcaaaagga attgaacatc     1020

atttgcaaag ctgtagatga cagttacaat gtgcagccag acactgtagc cccaatctgg     1080

aaccttcggg gcgtactcag caatgcctgg caccgtgtcc atgttcaggt ggtcccatga     1140


<210> 16
<211> 379
<212> PRT
<213> Mus musculus

<400> 16
Ser Pro Ser Val Glu Ala Ser Asp Pro Tyr Ala Asp Asp Pro Ile Arg 
1               5                   10                  15      


His Pro Ala Leu Arg Ile Asn Ser Gln Arg Pro Phe Asn Ala Glu Pro 
            20                  25                  30          


Pro Pro Glu Leu Leu Thr Glu Gly Tyr Ile Thr Pro Asn Pro Ile Phe 
        35                  40                  45              


Phe Thr Arg Asn His Leu Pro Val Pro Asn Leu Asp Pro His Thr Tyr 
    50                  55                  60                  


Arg Leu His Val Val Gly Ala Pro Gly Gly Gln Ser Leu Ser Leu Ser 
65                  70                  75                  80  


Leu Asp Asp Leu His Lys Phe Pro Lys His Glu Val Thr Val Thr Leu 
                85                  90                  95      


Gln Cys Ala Gly Asn Arg Arg Ser Glu Met Ser Lys Val Lys Glu Val 
            100                 105                 110         


Lys Gly Leu Glu Trp Arg Thr Gly Ala Ile Ser Thr Ala Arg Trp Ala 
        115                 120                 125             


Gly Ala Arg Leu Cys Asp Val Leu Ala Gln Ala Gly His Arg Leu Cys 
    130                 135                 140                 


Asp Ser Glu Ala His Val Cys Phe Glu Gly Leu Asp Ser Asp Pro Thr 
145                 150                 155                 160 


Gly Thr Ala Tyr Gly Ala Ser Ile Pro Leu Ala Arg Ala Met Asp Pro 
                165                 170                 175     


Glu Ala Glu Val Leu Leu Ala Tyr Glu Met Asn Gly Gln Pro Leu Pro 
            180                 185                 190         


Arg Asp His Gly Phe Pro Val Arg Val Val Val Pro Gly Val Val Gly 
        195                 200                 205             


Ala Arg His Val Lys Trp Leu Gly Arg Val Ser Val Glu Ser Glu Glu 
    210                 215                 220                 


Ser Tyr Ser His Trp Gln Arg Arg Asp Tyr Lys Gly Phe Ser Pro Ser 
225                 230                 235                 240 


Val Asp Trp Asp Thr Val Asn Phe Asp Leu Ala Pro Ser Ile Gln Glu 
                245                 250                 255     


Leu Pro Ile Gln Ser Ala Ile Thr Gln Pro Gln Asp Gly Ala Ile Val 
            260                 265                 270         


Glu Ser Gly Glu Val Thr Ile Lys Gly Tyr Ala Trp Ser Gly Gly Gly 
        275                 280                 285             


Arg Ala Val Ile Arg Val Asp Val Ser Val Asp Gly Gly Leu Thr Trp 
    290                 295                 300                 


Gln Glu Ala Glu Leu Glu Gly Glu Glu Gln Cys Pro Arg Lys Ala Trp 
305                 310                 315                 320 


Ala Trp Arg Ile Trp Gln Leu Lys Ala Gln Val Pro Ala Glu Gln Lys 
                325                 330                 335     


Glu Leu Asn Ile Ile Cys Lys Ala Val Asp Asp Ser Tyr Asn Val Gln 
            340                 345                 350         


Pro Asp Thr Val Ala Pro Ile Trp Asn Leu Arg Gly Val Leu Ser Asn 
        355                 360                 365             


Ala Trp His Arg Val His Val Gln Val Val Pro 
    370                 375                 


