                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  Non-acylated Exendin-4 Derivatives as Dual GLP-1/Glucagon 
       Receptor Agonists

<130>  DE2015/074 WO PCT / 60446P WO

<150>  EP 15 305 900.1
<151>  2015-06-12

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Amidated C-terminus

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  liraglutide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys derivatized at N6 with 
       (S)-4-carboxy-4-hexadecanoylamino-butyryl

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  3
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  4
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  4

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  6

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Arg Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro His 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Amidated C-terminus

<400>  8

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro His 
            20                  25                  30          


Ser Gly Pro Pro Pro Pro Pro Pro Pro 
        35                  40      


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Glu Glu 
1               5                   10                  15      


Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  11

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Arg Asp Phe Ile Glu Trp Leu Ile Ala Xaa Gly Pro His 
            20                  25                  30          


Ser Xaa Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Amidated C-terminus

<400>  12

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Arg Asp Phe Ile Glu Trp Leu Ile Ala Xaa Gly Pro His 
            20                  25                  30          


Ser Xaa Pro Pro Pro Pro Pro Pro Pro 
        35                  40      


<210>  13
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  13

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Glu Glu 
1               5                   10                  15      


Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly His Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  14

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Arg Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  15

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Arg Asp Phe Ile Glu Trp Leu Ile Ala Xaa Gly Pro Pro 
            20                  25                  30          


Ser Xaa Ala Pro Pro Pro Ser 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  16

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Glu Glu 
1               5                   10                  15      


Gln Arg Ala Arg Glu Phe Ile Glu Trp Leu Ile Ala Xaa Gly Pro Pro 
            20                  25                  30          


Ser Xaa Ala Pro Pro Pro Ser 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  17

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro His 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  18

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Xaa Gly Pro His 
            20                  25                  30          


Ser Xaa Ala Pro Pro Pro Ser 
        35                  


<210>  19
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  19

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Arg Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly His Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


