                         SEQUENCE LISTING

<110>  Inserm
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF 
       ALZHEIMER'S DISEASE

<130>  BIO15161 CARTIER/MC

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  595
<212>  PRT
<213>  Mus musculus

<400>  1

Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro Gln 
1               5                   10                  15      


Ile Ala Met Phe Cys Gly Lys Leu Asn Met His Met Asn Val Gln Asn 
            20                  25                  30          


Gly Lys Trp Glu Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Gly Thr 
        35                  40                  45              


Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln 
    50                  55                  60                  


Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn Trp 
65                  70                  75                  80  


Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Thr His Ile Val Ile 
                85                  90                  95      


Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val 
            100                 105                 110         


Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu 
        115                 120                 125             


Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu Lys 
    130                 135                 140                 


Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp 
145                 150                 155                 160 


Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser 
                165                 170                 175     


Asp Ser Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp 
            180                 185                 190         


Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Gly Glu Asp Lys Val 
        195                 200                 205             


Val Glu Val Ala Glu Glu Glu Glu Val Ala Asp Val Glu Glu Glu Glu 
    210                 215                 220                 


Ala Asp Asp Asp Glu Asp Val Glu Asp Gly Asp Glu Val Glu Glu Glu 
225                 230                 235                 240 


Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Thr Ala 
                245                 250                 255     


Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg Val 
            260                 265                 270         


Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu 
        275                 280                 285             


Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu 
    290                 295                 300                 


Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu 
305                 310                 315                 320 


Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys 
                325                 330                 335     


Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln 
            340                 345                 350         


Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg 
        355                 360                 365             


Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr 
    370                 375                 380                 


Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro His His Val Phe Asn 
385                 390                 395                 400 


Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr 
                405                 410                 415     


Leu Lys His Phe Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala 
            420                 425                 430         


Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg 
        435                 440                 445             


Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu 
    450                 455                 460                 


Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr 
465                 470                 475                 480 


Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr 
                485                 490                 495     


Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val 
            500                 505                 510         


Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro 
        515                 520                 525             


Trp His Pro Phe Gly Val Asp Ser Val Pro Ala Asn Thr Glu Asn Glu 
    530                 535                 540                 


Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr 
545                 550                 555                 560 


Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu 
                565                 570                 575     


Val Lys Met Asp Ala Glu Phe Gly His Asp Ser Gly Phe Glu Val Arg 
            580                 585                 590         


His Gln Lys 
        595 


<210>  2
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro Gln 
1               5                   10                  15      


Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln Asn 
            20                  25                  30          


Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp Thr 
        35                  40                  45              


Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln 
    50                  55                  60                  


Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn Trp 
65                  70                  75                  80  


Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val Ile 
                85                  90                  95      


Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val 
            100                 105                 110         


Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu 
        115                 120                 125             


Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu Lys 
    130                 135                 140                 


Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp 
145                 150                 155                 160 


Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser 
                165                 170                 175     


Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp 
            180                 185                 190         


Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val 
        195                 200                 205             


Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu 
    210                 215                 220                 


Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu 
225                 230                 235                 240 


Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile Ala 
                245                 250                 255     


Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg Val 
            260                 265                 270         


Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu 
        275                 280                 285             


Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu 
    290                 295                 300                 


Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu 
305                 310                 315                 320 


Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys 
                325                 330                 335     


Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln 
            340                 345                 350         


Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg 
        355                 360                 365             


Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr 
    370                 375                 380                 


Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn 
385                 390                 395                 400 


Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr 
                405                 410                 415     


Leu Lys His Phe Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala 
            420                 425                 430         


Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg 
        435                 440                 445             


Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu 
    450                 455                 460                 


Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr 
465                 470                 475                 480 


Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr 
                485                 490                 495     


Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val 
            500                 505                 510         


Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro 
        515                 520                 525             


Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu 
    530                 535                 540                 


Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr 
545                 550                 555                 560 


Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu 
                565                 570                 575     


Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His 
            580                 585                 590         


His Gln Lys 
        595 


<210>  3
<211>  1785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized nucleic acid sequence

<400>  3
ttggaggtgc ccaccgacgg caacgctgga ctgctggctg aaccccagat cgccatgttc       60

tgcggcaagc tgaacatgca catgaacgtg cagaacggca agtgggagag cgaccccagc      120

ggcaccaaga cctgcatcgg caccaaagag ggcatcctgc agtattgcca ggaagtgtac      180

cccgagctgc agatcaccaa cgtggtggaa gccaaccagc ccgtgaccat ccagaactgg      240

tgcaagaggg gcagaaagca gtgcaagacc cacacccaca tcgtgatccc ttacagatgc      300

ctcgtgggcg agttcgtgtc cgacgctctg ctggtgcccg acaagtgcaa gttcctgcat      360

caggaacgga tggacgtgtg cgagacacat ctgcactggc acaccgtggc caaagagaca      420

tgcagcgaga agtccaccaa cctgcacgac tacggcatgc tgctgccctg cggcatcgac      480

aagttcagag gcgtggaatt cgtgtgctgc cccctggccg aggaatccga ctctgtggat      540

agcgccgacg ccgaagagga cgactctgac gtgtggtggg gcggagccga cacagattac      600

gctgatggcg gcgaggacaa ggtggtggaa gtggctgaag aggaagaggt ggccgacgtg      660

gaagaagaag aggccgacga cgacgaggat gtggaagatg gcgacgaggt ggaagaggaa      720

gccgaggaac cctacgagga agccaccgag agaaccacca gcaccgccac cacaaccacc      780

accactaccg agagcgtgga agaggtcgtg cgggtgccaa caacagccgc ctctacacct      840

gacgccgtgg acaagtacct ggaaacccca ggcgacgaga acgagcacgc ccacttccag      900

aaggctaaag agagactgga agctaagcac cgcgagagaa tgagccaagt gatgagagag      960

tgggaggaag ctgagagaca ggccaagaac ctgcccaagg ccgacaagaa agccgtgatc     1020

cagcacttcc aggaaaaggt ggaaagcctg gaacaggaag ctgccaacga gagacagcag     1080

ctggtggaaa cccacatggc cagagtggaa gctatgctga acgacagaag aaggctggcc     1140

ctggaaaact acatcaccgc tctgcaggcc gtgcccccca gacctcacca cgtgttcaac     1200

atgctgaaga aatacgtgcg ggccgagcag aaggacagac agcacaccct gaagcacttc     1260

gagcacgtgc ggatggtgga ccccaagaag gccgcccaga tcagatccca agtgatgacc     1320

cacctgagag tgatctacga gaggatgaac cagagcctga gcctgctgta caacgtgccc     1380

gccgtggccg aagaaatcca ggatgaggtg gacgagctgc tgcagaaaga gcagaactac     1440

agcgacgacg tgctggccaa catgatcagc gagcccagaa tcagctacgg caacgacgcc     1500

ctgatgccca gcctgaccga gacaaagacc accgtggaac tgctgcccgt gaacggcgag     1560

ttcagcctgg atgacctgca gccctggcac cctttcggcg tggactctgt gcctgccaac     1620

acagagaacg aagtggaacc cgtggacgcc agacctgccg ctgatagagg cctgaccaca     1680

agacctggca gcggcctgac aaacatcaag accgaagaga tcagcgaagt gaagatggac     1740

gccgagttcg ggcacgacag cggctttgaa gtgcggcacc agaaa                     1785


<210>  4
<211>  1785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized nucleic acid sequence

<400>  4
ttggaggtgc ccaccgacgg caacgccgga ctgctggccg agccccagat cgccatgttc       60

tgcggcagac tgaacatgca catgaacgtg cagaacggca agtgggacag cgaccccagc      120

ggcaccaaga cctgcatcga caccaaagag ggcatcctgc agtattgcca agaagtgtac      180

cccgagctgc agatcaccaa cgtggtggaa gccaaccagc ccgtgaccat ccagaactgg      240

tgcaagcggg gcagaaagca gtgcaagacc cacccccact tcgtgatccc ttacagatgc      300

ctcgtgggcg agttcgtgtc cgacgccctg ctggtgcccg acaagtgcaa gttcctgcat      360

caagaacgga tggacgtgtg cgagacacat ctgcactggc acaccgtggc caaagagaca      420

tgcagcgaga agtccaccaa cctgcacgac tacggcatgc tgctgccctg cggcatcgac      480

aagttccggg gcgtggaatt cgtgtgctgc cccctggccg aggaatccga caacgtggac      540

agcgccgacg ccgaagagga cgacagcgac gtgtggtggg gcggagccga caccgattac      600

gccgacggca gcgaggacaa ggtggtggaa gtggctgaag aggaagaggt ggccgaggtc      660

gaggaagagg aagccgacga cgacgaggat gacgaggacg gcgacgaggt ggaagaagag      720

gccgaggaac cctacgagga agccaccgag cggaccacct ctatcgccac caccaccaca      780

accactaccg agagcgtgga agaggtcgtg cgggtgccaa ccaccgccgc ctctaccccc      840

gacgccgtgg acaagtacct ggaaacccct ggcgacgaga acgagcacgc ccacttccag      900

aaggccaaag agcggctgga agccaagcac cgcgagcgga tgagccaggt catgagagag      960

tgggaagaag ccgagcggca ggccaagaac ctgcccaagg ccgacaagaa agccgtgatc     1020

cagcacttcc aagaaaaggt cgagagcctg gaacaagaag ccgccaacga gcggcagcag     1080

ctggtggaaa cccacatggc cagagtggaa gccatgctga acgaccggcg gagactggcc     1140

ctggaaaact acatcaccgc tctgcaggcc gtgcccccca gaccccggca cgtgttcaac     1200

atgctgaaga aatacgtgcg ggccgagcag aaggaccggc agcacaccct gaagcacttc     1260

gagcacgtgc ggatggtgga ccccaagaag gccgcccaga tccgctctca ggtcatgacc     1320

cacctgagag tgatctacga gagaatgaac cagagcctga gcctgctgta caacgtgccc     1380

gccgtggccg aagaaatcca ggatgaggtg gacgagctgc tgcagaaaga gcagaactac     1440

agcgacgacg tgctggccaa catgatcagc gagccccgga tcagctacgg caacgacgcc     1500

ctgatgccca gcctgaccga gacaaagacc accgtggaac tgctgcccgt gaacggcgag     1560

ttcagcctgg acgacctgca gccctggcac agcttcggcg ctgatagcgt gcccgccaac     1620

accgagaatg aggtggaacc cgtggacgcc agacctgccg ccgatagagg cctgaccaca     1680

agacctggca gcggcctgac caacatcaag accgaagaga tcagcgaagt gaagatggac     1740

gccgagttcc ggcacgacag cggctacgag gtgcaccacc agaaa                     1785


<210>  5
<211>  3740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  complete sequence of the expression cassette

<400>  5
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatcta ggatcacgcg      180

ttctagaaat attaaggtac gggaggtact tggagcggcc gcaataaaat atctttattt      240

tcattacatc tgtgtgttgg ttttttgtgt gaatcgatag tactaacata cgctctccat      300

caaaacaaaa cgaaacaaaa caaactagca aaataggctg tccccagtgc aagtgggttt      360

taggaccagg atgaggcggg gtgggggtgc ctacctgacg accgaccccg acccactgga      420

caagcaccca acccccattc cccaaattgc gcatccccta tcagagaggg ggaggggaaa      480

caggatgcgg cgaggcgcgt gcgcactgcc agcttcagca ccgcggacag tgccttcgcc      540

cccgcctggc ggcgcgcgcc accgccgcct cagcactgaa ggcgcgctga cgtcactcgc      600

cggtcccccg caaactcccc ttcccggcca ccttggtcgc gtccgcgccg ccgccggccc      660

agccggaccg caccacgcga ggcgcgagat aggggggcac gggcgcgacc atctgcgctg      720

cggcgccggc gactcagcgc tgcctcagtc tgcggtgggc agcggaggag tcgtgtcgtg      780

cctgagagcg cagtcgaatt gctagcgggg atccaccggt cgccaccatg ctgccttctc      840

tggctttgct gctgctggcc gcttggacag tgcgggccta cccttacgac gtgcccgact      900

acgcttaccc ctacgatgtg cctgattatg cattggaggt gcccaccgac ggcaacgctg      960

gactgctggc tgaaccccag atcgccatgt tctgcggcaa gctgaacatg cacatgaacg     1020

tgcagaacgg caagtgggag agcgacccca gcggcaccaa gacctgcatc ggcaccaaag     1080

agggcatcct gcagtattgc caggaagtgt accccgagct gcagatcacc aacgtggtgg     1140

aagccaacca gcccgtgacc atccagaact ggtgcaagag gggcagaaag cagtgcaaga     1200

cccacaccca catcgtgatc ccttacagat gcctcgtggg cgagttcgtg tccgacgctc     1260

tgctggtgcc cgacaagtgc aagttcctgc atcaggaacg gatggacgtg tgcgagacac     1320

atctgcactg gcacaccgtg gccaaagaga catgcagcga gaagtccacc aacctgcacg     1380

actacggcat gctgctgccc tgcggcatcg acaagttcag aggcgtggaa ttcgtgtgct     1440

gccccctggc cgaggaatcc gactctgtgg atagcgccga cgccgaagag gacgactctg     1500

acgtgtggtg gggcggagcc gacacagatt acgctgatgg cggcgaggac aaggtggtgg     1560

aagtggctga agaggaagag gtggccgacg tggaagaaga agaggccgac gacgacgagg     1620

atgtggaaga tggcgacgag gtggaagagg aagccgagga accctacgag gaagccaccg     1680

agagaaccac cagcaccgcc accacaacca ccaccactac cgagagcgtg gaagaggtcg     1740

tgcgggtgcc aacaacagcc gcctctacac ctgacgccgt ggacaagtac ctggaaaccc     1800

caggcgacga gaacgagcac gcccacttcc agaaggctaa agagagactg gaagctaagc     1860

accgcgagag aatgagccaa gtgatgagag agtgggagga agctgagaga caggccaaga     1920

acctgcccaa ggccgacaag aaagccgtga tccagcactt ccaggaaaag gtggaaagcc     1980

tggaacagga agctgccaac gagagacagc agctggtgga aacccacatg gccagagtgg     2040

aagctatgct gaacgacaga agaaggctgg ccctggaaaa ctacatcacc gctctgcagg     2100

ccgtgccccc cagacctcac cacgtgttca acatgctgaa gaaatacgtg cgggccgagc     2160

agaaggacag acagcacacc ctgaagcact tcgagcacgt gcggatggtg gaccccaaga     2220

aggccgccca gatcagatcc caagtgatga cccacctgag agtgatctac gagaggatga     2280

accagagcct gagcctgctg tacaacgtgc ccgccgtggc cgaagaaatc caggatgagg     2340

tggacgagct gctgcagaaa gagcagaact acagcgacga cgtgctggcc aacatgatca     2400

gcgagcccag aatcagctac ggcaacgacg ccctgatgcc cagcctgacc gagacaaaga     2460

ccaccgtgga actgctgccc gtgaacggcg agttcagcct ggatgacctg cagccctggc     2520

accctttcgg cgtggactct gtgcctgcca acacagagaa cgaagtggaa cccgtggacg     2580

ccagacctgc cgctgataga ggcctgacca caagacctgg cagcggcctg acaaacatca     2640

agaccgaaga gatcagcgaa gtgaagatgg acgccgagtt cgggcacgac agcggctttg     2700

aagtgcggca ccagaaatag aagcttatcg ataatcaacc tctggattac aaaatttgtg     2760

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     2820

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     2880

aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg     2940

tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc     3000

tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct     3060

gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt     3120

cggggaagct gacgtccttt ccatggctgc tcgcctgtgt tgccacctgg attctgcgcg     3180

ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc     3240

tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct     3300

ccctttgggc cgcctccccg cctgatcgat accgtcgact agagctcgct gatcagcctc     3360

gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac     3420

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg     3480

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     3540

ttgggaagac aatagcaggc atgctgggga gagatctgag gaacccctag tgatggagtt     3600

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg     3660

tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc     3720

caaccccccc cccccccccc                                                 3740


<210>  6
<211>  3740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  complete sequence of the expression cassette

<400>  6
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatcta ggatcacgcg      180

ttctagaaat attaaggtac gggaggtact tggagcggcc gcaataaaat atctttattt      240

tcattacatc tgtgtgttgg ttttttgtgt gaatcgatag tactaacata cgctctccat      300

caaaacaaaa cgaaacaaaa caaactagca aaataggctg tccccagtgc aagtgggttt      360

taggaccagg atgaggcggg gtgggggtgc ctacctgacg accgaccccg acccactgga      420

caagcaccca acccccattc cccaaattgc gcatccccta tcagagaggg ggaggggaaa      480

caggatgcgg cgaggcgcgt gcgcactgcc agcttcagca ccgcggacag tgccttcgcc      540

cccgcctggc ggcgcgcgcc accgccgcct cagcactgaa ggcgcgctga cgtcactcgc      600

cggtcccccg caaactcccc ttcccggcca ccttggtcgc gtccgcgccg ccgccggccc      660

agccggaccg caccacgcga ggcgcgagat aggggggcac gggcgcgacc atctgcgctg      720

cggcgccggc gactcagcgc tgcctcagtc tgcggtgggc agcggaggag tcgtgtcgtg      780

cctgagagcg cagtcgaatt gctagcgggg atccaccggt cgccaccatg ctgcctggac      840

tggctctgct gctgctggcc gcctggacag ccagagccta cccctacgac gtgcccgact      900

acgcctaccc ttatgatgtg cctgactatg cattggaggt gcccaccgac ggcaacgccg      960

gactgctggc cgagccccag atcgccatgt tctgcggcag actgaacatg cacatgaacg     1020

tgcagaacgg caagtgggac agcgacccca gcggcaccaa gacctgcatc gacaccaaag     1080

agggcatcct gcagtattgc caagaagtgt accccgagct gcagatcacc aacgtggtgg     1140

aagccaacca gcccgtgacc atccagaact ggtgcaagcg gggcagaaag cagtgcaaga     1200

cccaccccca cttcgtgatc ccttacagat gcctcgtggg cgagttcgtg tccgacgccc     1260

tgctggtgcc cgacaagtgc aagttcctgc atcaagaacg gatggacgtg tgcgagacac     1320

atctgcactg gcacaccgtg gccaaagaga catgcagcga gaagtccacc aacctgcacg     1380

actacggcat gctgctgccc tgcggcatcg acaagttccg gggcgtggaa ttcgtgtgct     1440

gccccctggc cgaggaatcc gacaacgtgg acagcgccga cgccgaagag gacgacagcg     1500

acgtgtggtg gggcggagcc gacaccgatt acgccgacgg cagcgaggac aaggtggtgg     1560

aagtggctga agaggaagag gtggccgagg tcgaggaaga ggaagccgac gacgacgagg     1620

atgacgagga cggcgacgag gtggaagaag aggccgagga accctacgag gaagccaccg     1680

agcggaccac ctctatcgcc accaccacca caaccactac cgagagcgtg gaagaggtcg     1740

tgcgggtgcc aaccaccgcc gcctctaccc ccgacgccgt ggacaagtac ctggaaaccc     1800

ctggcgacga gaacgagcac gcccacttcc agaaggccaa agagcggctg gaagccaagc     1860

accgcgagcg gatgagccag gtcatgagag agtgggaaga agccgagcgg caggccaaga     1920

acctgcccaa ggccgacaag aaagccgtga tccagcactt ccaagaaaag gtcgagagcc     1980

tggaacaaga agccgccaac gagcggcagc agctggtgga aacccacatg gccagagtgg     2040

aagccatgct gaacgaccgg cggagactgg ccctggaaaa ctacatcacc gctctgcagg     2100

ccgtgccccc cagaccccgg cacgtgttca acatgctgaa gaaatacgtg cgggccgagc     2160

agaaggaccg gcagcacacc ctgaagcact tcgagcacgt gcggatggtg gaccccaaga     2220

aggccgccca gatccgctct caggtcatga cccacctgag agtgatctac gagagaatga     2280

accagagcct gagcctgctg tacaacgtgc ccgccgtggc cgaagaaatc caggatgagg     2340

tggacgagct gctgcagaaa gagcagaact acagcgacga cgtgctggcc aacatgatca     2400

gcgagccccg gatcagctac ggcaacgacg ccctgatgcc cagcctgacc gagacaaaga     2460

ccaccgtgga actgctgccc gtgaacggcg agttcagcct ggacgacctg cagccctggc     2520

acagcttcgg cgctgatagc gtgcccgcca acaccgagaa tgaggtggaa cccgtggacg     2580

ccagacctgc cgccgataga ggcctgacca caagacctgg cagcggcctg accaacatca     2640

agaccgaaga gatcagcgaa gtgaagatgg acgccgagtt ccggcacgac agcggctacg     2700

aggtgcacca ccagaaatag aagcttatcg ataatcaacc tctggattac aaaatttgtg     2760

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     2820

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     2880

aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg     2940

tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc     3000

tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct     3060

gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt     3120

cggggaagct gacgtccttt ccatggctgc tcgcctgtgt tgccacctgg attctgcgcg     3180

ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc     3240

tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct     3300

ccctttgggc cgcctccccg cctgatcgat accgtcgact agagctcgct gatcagcctc     3360

gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac     3420

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg     3480

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     3540

ttgggaagac aatagcaggc atgctgggga gagatctgag gaacccctag tgatggagtt     3600

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg     3660

tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc     3720

caaccccccc cccccccccc                                                 3740


