                         SEQUENCE LISTING

<110>  Danmarks Tekniske Universitet
 
<120>  Use of heterologous expressed polyketide synthase and 'small 
       molecule foldases' to make aromatic and cyclic compounds

<130>  P2011PC00

<150>  EP15171430.0
<151>  2015-06-10

<160>  145   

<170>  PatentIn version 3.5

<210>  1
<211>  1209
<212>  DNA
<213>  Gerbera hybrida


<220>
<221>  CDS
<222>  (1)..(1209)
<223>  2-PS gene [GenBank ID number Z38097.2) encoding a  Type III 
       triketide synthase (GenBank ID number P48391.2)

<400>  1
atg gga tct tac tca tcc gat gat gtg gag gtg att cgt gag gcc gga         48
Met Gly Ser Tyr Ser Ser Asp Asp Val Glu Val Ile Arg Glu Ala Gly           
1               5                   10                  15                

cgg gca caa ggt tta gcc acg att ctt gcc att ggc act gct act cct         96
Arg Ala Gln Gly Leu Ala Thr Ile Leu Ala Ile Gly Thr Ala Thr Pro           
            20                  25                  30                    

ccc aat tgc gtc gct caa gct gat tat gca gac tat tat ttt cgt gtc        144
Pro Asn Cys Val Ala Gln Ala Asp Tyr Ala Asp Tyr Tyr Phe Arg Val           
        35                  40                  45                        

act aag agc gaa cat atg gtt gat ctt aaa gag aaa ttt aaa cgc att        192
Thr Lys Ser Glu His Met Val Asp Leu Lys Glu Lys Phe Lys Arg Ile           
    50                  55                  60                            

tgt gag aaa aca gcg ata aag aaa cga tac cta gcc ctc acc gaa gac        240
Cys Glu Lys Thr Ala Ile Lys Lys Arg Tyr Leu Ala Leu Thr Glu Asp           
65                  70                  75                  80            

tat ctg caa gag aac cca aca atg tgt gag ttc atg gct cca tcc tta        288
Tyr Leu Gln Glu Asn Pro Thr Met Cys Glu Phe Met Ala Pro Ser Leu           
                85                  90                  95                

aac gct cga caa gac cta gtg gtc acc ggc gtc cca atg ctt ggc aaa        336
Asn Ala Arg Gln Asp Leu Val Val Thr Gly Val Pro Met Leu Gly Lys           
            100                 105                 110                   

gaa gcc gca gtc aag gcc att gat gaa tgg gga cta cca aaa tcc aag        384
Glu Ala Ala Val Lys Ala Ile Asp Glu Trp Gly Leu Pro Lys Ser Lys           
        115                 120                 125                       

atc acc cac ctc atc ttc tgc acc acc gct ggc gtt gac atg ccc ggt        432
Ile Thr His Leu Ile Phe Cys Thr Thr Ala Gly Val Asp Met Pro Gly           
    130                 135                 140                           

gct gac tat caa ctc gtc aaa ctc ctt ggt ctc tcc cct tca gtc aaa        480
Ala Asp Tyr Gln Leu Val Lys Leu Leu Gly Leu Ser Pro Ser Val Lys           
145                 150                 155                 160           

cgc tat atg ttg tac caa cag gga tgt gcc gcc ggc ggc aca gtc ctc        528
Arg Tyr Met Leu Tyr Gln Gln Gly Cys Ala Ala Gly Gly Thr Val Leu           
                165                 170                 175               

cgg cta gcc aag gac ctt gct gaa aac aac aag ggc tca cga gtc ctt        576
Arg Leu Ala Lys Asp Leu Ala Glu Asn Asn Lys Gly Ser Arg Val Leu           
            180                 185                 190                   

atc gtc tgc tcc gag atc act gct atc tta ttc cat gga ccc aat gag        624
Ile Val Cys Ser Glu Ile Thr Ala Ile Leu Phe His Gly Pro Asn Glu           
        195                 200                 205                       

aac cac ctt gac tca ctc gtc gct caa gct tta ttc gga gac gga gct        672
Asn His Leu Asp Ser Leu Val Ala Gln Ala Leu Phe Gly Asp Gly Ala           
    210                 215                 220                           

gca gca ctc att gtg ggt tca ggc cct cac ttg gcc gta gaa cgg cca        720
Ala Ala Leu Ile Val Gly Ser Gly Pro His Leu Ala Val Glu Arg Pro           
225                 230                 235                 240           

ata ttc gag atc gtg tca act gat caa aca atc ttg ccg gac act gag        768
Ile Phe Glu Ile Val Ser Thr Asp Gln Thr Ile Leu Pro Asp Thr Glu           
                245                 250                 255               

aag gca atg aag tta cac ttg aga gag gga ggg ttg acg ttt cag ttg        816
Lys Ala Met Lys Leu His Leu Arg Glu Gly Gly Leu Thr Phe Gln Leu           
            260                 265                 270                   

cat aga gat gta ccc ttg atg gtc gca aag aac ata gag aac gca gcg        864
His Arg Asp Val Pro Leu Met Val Ala Lys Asn Ile Glu Asn Ala Ala           
        275                 280                 285                       

gag aaa gcg ttg tct cca cta ggg ata act gat tgg aac tca gtt ttc        912
Glu Lys Ala Leu Ser Pro Leu Gly Ile Thr Asp Trp Asn Ser Val Phe           
    290                 295                 300                           

tgg atg gtg cac cca ggt ggt cga gcc ata ttg gac cag gtg gag cga        960
Trp Met Val His Pro Gly Gly Arg Ala Ile Leu Asp Gln Val Glu Arg           
305                 310                 315                 320           

aaa cta aac ctt aag gaa gat aag tta agg gct agc agg cat gtg ctt       1008
Lys Leu Asn Leu Lys Glu Asp Lys Leu Arg Ala Ser Arg His Val Leu           
                325                 330                 335               

agt gaa tac gga aac ctg att agc gct tgt gtg ttg ttc atc att gac       1056
Ser Glu Tyr Gly Asn Leu Ile Ser Ala Cys Val Leu Phe Ile Ile Asp           
            340                 345                 350                   

gag gtg agg aag aga tct atg gcg gaa ggg aag agt aca acc ggt gaa       1104
Glu Val Arg Lys Arg Ser Met Ala Glu Gly Lys Ser Thr Thr Gly Glu           
        355                 360                 365                       

ggt ttg gat tgc ggt gtt ttg ttt gga ttt gga ccg ggt atg act gtt       1152
Gly Leu Asp Cys Gly Val Leu Phe Gly Phe Gly Pro Gly Met Thr Val           
    370                 375                 380                           

gag act gtt gtt ctt cgt agc gtc cgc gtt act gct gcg gtt gcc aat       1200
Glu Thr Val Val Leu Arg Ser Val Arg Val Thr Ala Ala Val Ala Asn           
385                 390                 395                 400           

gga aac tga                                                           1209
Gly Asn                                                                   
                                                                          


<210>  2
<211>  402
<212>  PRT
<213>  Gerbera hybrida

<400>  2

Met Gly Ser Tyr Ser Ser Asp Asp Val Glu Val Ile Arg Glu Ala Gly 
1               5                   10                  15      


Arg Ala Gln Gly Leu Ala Thr Ile Leu Ala Ile Gly Thr Ala Thr Pro 
            20                  25                  30          


Pro Asn Cys Val Ala Gln Ala Asp Tyr Ala Asp Tyr Tyr Phe Arg Val 
        35                  40                  45              


Thr Lys Ser Glu His Met Val Asp Leu Lys Glu Lys Phe Lys Arg Ile 
    50                  55                  60                  


Cys Glu Lys Thr Ala Ile Lys Lys Arg Tyr Leu Ala Leu Thr Glu Asp 
65                  70                  75                  80  


Tyr Leu Gln Glu Asn Pro Thr Met Cys Glu Phe Met Ala Pro Ser Leu 
                85                  90                  95      


Asn Ala Arg Gln Asp Leu Val Val Thr Gly Val Pro Met Leu Gly Lys 
            100                 105                 110         


Glu Ala Ala Val Lys Ala Ile Asp Glu Trp Gly Leu Pro Lys Ser Lys 
        115                 120                 125             


Ile Thr His Leu Ile Phe Cys Thr Thr Ala Gly Val Asp Met Pro Gly 
    130                 135                 140                 


Ala Asp Tyr Gln Leu Val Lys Leu Leu Gly Leu Ser Pro Ser Val Lys 
145                 150                 155                 160 


Arg Tyr Met Leu Tyr Gln Gln Gly Cys Ala Ala Gly Gly Thr Val Leu 
                165                 170                 175     


Arg Leu Ala Lys Asp Leu Ala Glu Asn Asn Lys Gly Ser Arg Val Leu 
            180                 185                 190         


Ile Val Cys Ser Glu Ile Thr Ala Ile Leu Phe His Gly Pro Asn Glu 
        195                 200                 205             


Asn His Leu Asp Ser Leu Val Ala Gln Ala Leu Phe Gly Asp Gly Ala 
    210                 215                 220                 


Ala Ala Leu Ile Val Gly Ser Gly Pro His Leu Ala Val Glu Arg Pro 
225                 230                 235                 240 


Ile Phe Glu Ile Val Ser Thr Asp Gln Thr Ile Leu Pro Asp Thr Glu 
                245                 250                 255     


Lys Ala Met Lys Leu His Leu Arg Glu Gly Gly Leu Thr Phe Gln Leu 
            260                 265                 270         


His Arg Asp Val Pro Leu Met Val Ala Lys Asn Ile Glu Asn Ala Ala 
        275                 280                 285             


Glu Lys Ala Leu Ser Pro Leu Gly Ile Thr Asp Trp Asn Ser Val Phe 
    290                 295                 300                 


Trp Met Val His Pro Gly Gly Arg Ala Ile Leu Asp Gln Val Glu Arg 
305                 310                 315                 320 


Lys Leu Asn Leu Lys Glu Asp Lys Leu Arg Ala Ser Arg His Val Leu 
                325                 330                 335     


Ser Glu Tyr Gly Asn Leu Ile Ser Ala Cys Val Leu Phe Ile Ile Asp 
            340                 345                 350         


Glu Val Arg Lys Arg Ser Met Ala Glu Gly Lys Ser Thr Thr Gly Glu 
        355                 360                 365             


Gly Leu Asp Cys Gly Val Leu Phe Gly Phe Gly Pro Gly Met Thr Val 
    370                 375                 380                 


Glu Thr Val Val Leu Arg Ser Val Arg Val Thr Ala Ala Val Ala Asn 
385                 390                 395                 400 


Gly Asn 
        


<210>  3
<211>  1089
<212>  DNA
<213>  Pseudomonas fluorescens


<220>
<221>  CDS
<222>  (1)..(1089)
<223>  PhlD [GenBank ID number JN561597.1 position 2882 to 3970) 
       encoding a Type III tetraketide synthase (GenBank ID number 
       AEW67127.1)

<400>  3
atg ctt cta act tta ttg gct tct cgc cga gga ctt gtc atg tct act         48
Met Leu Leu Thr Leu Leu Ala Ser Arg Arg Gly Leu Val Met Ser Thr           
1               5                   10                  15                

ctt tgt aaa ccc agt ctg ttg ttt ccg caa tac aag atc acc cag caa         96
Leu Cys Lys Pro Ser Leu Leu Phe Pro Gln Tyr Lys Ile Thr Gln Gln           
            20                  25                  30                    

caa atg atc gag cat cta gag cag ttg cat gat gat cat cca cga atg        144
Gln Met Ile Glu His Leu Glu Gln Leu His Asp Asp His Pro Arg Met           
        35                  40                  45                        

gca ctt gcc aaa cga atg att caa aac acg cag gtg aac gaa cgg cac        192
Ala Leu Ala Lys Arg Met Ile Gln Asn Thr Gln Val Asn Glu Arg His           
    50                  55                  60                            

ttg gtc ctg cct atc gat gaa ctg gcg gtg cac acc ggc ttc acc cac        240
Leu Val Leu Pro Ile Asp Glu Leu Ala Val His Thr Gly Phe Thr His           
65                  70                  75                  80            

cgc agt atc gtt tat gag cgc gaa gcc cgc cgc atg tca tcc atc gcg        288
Arg Ser Ile Val Tyr Glu Arg Glu Ala Arg Arg Met Ser Ser Ile Ala           
                85                  90                  95                

gcg cgc caa gcc atc gag aat gcc ggg ctg acc atc gat gac att cgc        336
Ala Arg Gln Ala Ile Glu Asn Ala Gly Leu Thr Ile Asp Asp Ile Arg           
            100                 105                 110                   

atg gtc gcg gtg aca tcg tgc acc ggt ttc atg atg ccc tcg ctg aca        384
Met Val Ala Val Thr Ser Cys Thr Gly Phe Met Met Pro Ser Leu Thr           
        115                 120                 125                       

gcc cac ttg atc aat gac ctg ggc ctg cga acg tcg acc gta caa ctg        432
Ala His Leu Ile Asn Asp Leu Gly Leu Arg Thr Ser Thr Val Gln Leu           
    130                 135                 140                           

ccc atc gct caa ctg ggc tgc gtg gca ggc gct gcg gcg atc aat cga        480
Pro Ile Ala Gln Leu Gly Cys Val Ala Gly Ala Ala Ala Ile Asn Arg           
145                 150                 155                 160           

gcc aat gac ttc gcc agc cgg gcg ccg gac aac cat gtc ctc atc gtc        528
Ala Asn Asp Phe Ala Ser Arg Ala Pro Asp Asn His Val Leu Ile Val           
                165                 170                 175               

tcc ctg gag ttc tca tcg ctc tgc tat caa ccc cag gac acc aag ttg        576
Ser Leu Glu Phe Ser Ser Leu Cys Tyr Gln Pro Gln Asp Thr Lys Leu           
            180                 185                 190                   

cac gcg ttc ata tca gcc gcg tta ttc ggc gat gcc gta tcg gcc tgc        624
His Ala Phe Ile Ser Ala Ala Leu Phe Gly Asp Ala Val Ser Ala Cys           
        195                 200                 205                       

gtc atg cgc gcc gat gac cag gcg cct ggt ttc aag atc gcc aat acc        672
Val Met Arg Ala Asp Asp Gln Ala Pro Gly Phe Lys Ile Ala Asn Thr           
    210                 215                 220                           

ggg tct tac ttc ctg cct gat agc gag cac tac att aaa tac gac gtt        720
Gly Ser Tyr Phe Leu Pro Asp Ser Glu His Tyr Ile Lys Tyr Asp Val           
225                 230                 235                 240           

aaa gac agc ggc ttt cat ttc acc ttg gac aag gct gtc atg aac tcc        768
Lys Asp Ser Gly Phe His Phe Thr Leu Asp Lys Ala Val Met Asn Ser           
                245                 250                 255               

att aaa gat gtc gca ccg atg atg gag gaa ttg aac tac gag acc ttc        816
Ile Lys Asp Val Ala Pro Met Met Glu Glu Leu Asn Tyr Glu Thr Phe           
            260                 265                 270                   

aat caa cat tgc gct caa aat gac ttt ttc atc ttc cat acc ggc gga        864
Asn Gln His Cys Ala Gln Asn Asp Phe Phe Ile Phe His Thr Gly Gly           
        275                 280                 285                       

cgg aaa att ctt gat gaa ctg gtc ctg caa ctg gac ttg gaa ccc ggt        912
Arg Lys Ile Leu Asp Glu Leu Val Leu Gln Leu Asp Leu Glu Pro Gly           
    290                 295                 300                           

cgg gtc gcg cag tct cgc gac agt ttg agc gaa gcc ggg aac atc gcc        960
Arg Val Ala Gln Ser Arg Asp Ser Leu Ser Glu Ala Gly Asn Ile Ala           
305                 310                 315                 320           

agc gtg gtg gtc ttc gat gtg ctc aag cgc caa ttc gac agc gga cct       1008
Ser Val Val Val Phe Asp Val Leu Lys Arg Gln Phe Asp Ser Gly Pro           
                325                 330                 335               

gtc aat ggc gcg acg ggc atg ttg gcg gcc ttc ggc ccg ggt ttc acc       1056
Val Asn Gly Ala Thr Gly Met Leu Ala Ala Phe Gly Pro Gly Phe Thr           
            340                 345                 350                   

gct gaa atg gcc gtg ggc aag tgg gtc gcc tga                           1089
Ala Glu Met Ala Val Gly Lys Trp Val Ala                                   
        355                 360                                           


<210>  4
<211>  362
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  4

Met Leu Leu Thr Leu Leu Ala Ser Arg Arg Gly Leu Val Met Ser Thr 
1               5                   10                  15      


Leu Cys Lys Pro Ser Leu Leu Phe Pro Gln Tyr Lys Ile Thr Gln Gln 
            20                  25                  30          


Gln Met Ile Glu His Leu Glu Gln Leu His Asp Asp His Pro Arg Met 
        35                  40                  45              


Ala Leu Ala Lys Arg Met Ile Gln Asn Thr Gln Val Asn Glu Arg His 
    50                  55                  60                  


Leu Val Leu Pro Ile Asp Glu Leu Ala Val His Thr Gly Phe Thr His 
65                  70                  75                  80  


Arg Ser Ile Val Tyr Glu Arg Glu Ala Arg Arg Met Ser Ser Ile Ala 
                85                  90                  95      


Ala Arg Gln Ala Ile Glu Asn Ala Gly Leu Thr Ile Asp Asp Ile Arg 
            100                 105                 110         


Met Val Ala Val Thr Ser Cys Thr Gly Phe Met Met Pro Ser Leu Thr 
        115                 120                 125             


Ala His Leu Ile Asn Asp Leu Gly Leu Arg Thr Ser Thr Val Gln Leu 
    130                 135                 140                 


Pro Ile Ala Gln Leu Gly Cys Val Ala Gly Ala Ala Ala Ile Asn Arg 
145                 150                 155                 160 


Ala Asn Asp Phe Ala Ser Arg Ala Pro Asp Asn His Val Leu Ile Val 
                165                 170                 175     


Ser Leu Glu Phe Ser Ser Leu Cys Tyr Gln Pro Gln Asp Thr Lys Leu 
            180                 185                 190         


His Ala Phe Ile Ser Ala Ala Leu Phe Gly Asp Ala Val Ser Ala Cys 
        195                 200                 205             


Val Met Arg Ala Asp Asp Gln Ala Pro Gly Phe Lys Ile Ala Asn Thr 
    210                 215                 220                 


Gly Ser Tyr Phe Leu Pro Asp Ser Glu His Tyr Ile Lys Tyr Asp Val 
225                 230                 235                 240 


Lys Asp Ser Gly Phe His Phe Thr Leu Asp Lys Ala Val Met Asn Ser 
                245                 250                 255     


Ile Lys Asp Val Ala Pro Met Met Glu Glu Leu Asn Tyr Glu Thr Phe 
            260                 265                 270         


Asn Gln His Cys Ala Gln Asn Asp Phe Phe Ile Phe His Thr Gly Gly 
        275                 280                 285             


Arg Lys Ile Leu Asp Glu Leu Val Leu Gln Leu Asp Leu Glu Pro Gly 
    290                 295                 300                 


Arg Val Ala Gln Ser Arg Asp Ser Leu Ser Glu Ala Gly Asn Ile Ala 
305                 310                 315                 320 


Ser Val Val Val Phe Asp Val Leu Lys Arg Gln Phe Asp Ser Gly Pro 
                325                 330                 335     


Val Asn Gly Ala Thr Gly Met Leu Ala Ala Phe Gly Pro Gly Phe Thr 
            340                 345                 350         


Ala Glu Met Ala Val Gly Lys Trp Val Ala 
        355                 360         


<210>  5
<211>  1212
<212>  DNA
<213>  Aloe arborescens


<220>
<221>  CDS
<222>  (1)..(1212)
<223>  PCS [GenBank ID number AY823626) encoding a Type III pentaketide 
       synthase (GenBank ID number AAX35541.1)

<400>  5
atg agt tca ctc tcc aac tct ctg ccg ttg atg gag gat gtg cag ggc         48
Met Ser Ser Leu Ser Asn Ser Leu Pro Leu Met Glu Asp Val Gln Gly           
1               5                   10                  15                

atc cga aag gcc caa aag gca gac gga act gca acc gtg atg gcc atc         96
Ile Arg Lys Ala Gln Lys Ala Asp Gly Thr Ala Thr Val Met Ala Ile           
            20                  25                  30                    

gga aca gct cac cca cct cat atc ttt ccg cag gac act tac gct gat        144
Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp           
        35                  40                  45                        

gtc tac ttc cgg gcc acc aac agc gag cac aag gtc gag ctc aag aag        192
Val Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys           
    50                  55                  60                            

aag ttc gat cac atc tgc aag aaa aca atg ata ggg aag cgt tac ttc        240
Lys Phe Asp His Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe           
65                  70                  75                  80            

aac tat gac gag gag ttc ttg aag aag tat ccc aac att act tca tat        288
Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Tyr           
                85                  90                  95                

gac gag ccc agc ctc aac gac agg cag gac att tgc gtt cct ggg gtg        336
Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val           
            100                 105                 110                   

ccg gcc ctg ggg aca gaa gcg gct gtg aag gcc atc gag gaa tgg gga        384
Pro Ala Leu Gly Thr Glu Ala Ala Val Lys Ala Ile Glu Glu Trp Gly           
        115                 120                 125                       

cgc ccg aag tct gag atc act cac ctc gtg ttc tgc acc tcc tgc ggt        432
Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly           
    130                 135                 140                           

gtc gac atg cct agc gcc gat ttc cag tgc gct aag ctc ctt ggc ctc        480
Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu           
145                 150                 155                 160           

cat gcc aat gtc aac aag tac tgc atc tac atg cag gga tgc tat gct        528
His Ala Asn Val Asn Lys Tyr Cys Ile Tyr Met Gln Gly Cys Tyr Ala           
                165                 170                 175               

ggt ggc acc gtc atg cgg tat gcc aag gat ctg gcc gag aac aac cgt        576
Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg           
            180                 185                 190                   

ggt gct cgc gtt ctt gtg gtg tgc gcg gag ctc acc atc atg atg ctt        624
Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Met Met Leu           
        195                 200                 205                       

cgc gcc ccc aac gag acc cat ctc gac aat gcc atc ggc atc tct cta        672
Arg Ala Pro Asn Glu Thr His Leu Asp Asn Ala Ile Gly Ile Ser Leu           
    210                 215                 220                           

ttt gga gat gga gct gct gca ctg atc att ggg tcg gac ccc atc att        720
Phe Gly Asp Gly Ala Ala Ala Leu Ile Ile Gly Ser Asp Pro Ile Ile           
225                 230                 235                 240           

ggt gtc gag aag ccc atg ttc gag att gtg tgc acc aag caa act gtg        768
Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Thr Lys Gln Thr Val           
                245                 250                 255               

atc cca aac act gaa gat gtt atc cat ctc cac ttg agg gag acg ggt        816
Ile Pro Asn Thr Glu Asp Val Ile His Leu His Leu Arg Glu Thr Gly           
            260                 265                 270                   

atg atg ttc tac cta agc aag ggc agt ccc atg acc atc tcc aat aac        864
Met Met Phe Tyr Leu Ser Lys Gly Ser Pro Met Thr Ile Ser Asn Asn           
        275                 280                 285                       

gta gag gcc tgc ctt att gat gtg ttc aag tcg gtg ggg ata act cct        912
Val Glu Ala Cys Leu Ile Asp Val Phe Lys Ser Val Gly Ile Thr Pro           
    290                 295                 300                           

cca gag gac tgg aac tct ctc ttc tgg atc cct cat ccc ggt ggt cgg        960
Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg           
305                 310                 315                 320           

gct atc ctc gac caa gtt gag gcc aag cta aag ctt cgc ccc gag aag       1008
Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys           
                325                 330                 335               

ttc agg gcg gct cga act gtt ctg tgg gat tac ggc aac atg gtg agc       1056
Phe Arg Ala Ala Arg Thr Val Leu Trp Asp Tyr Gly Asn Met Val Ser           
            340                 345                 350                   

gca agt gtg ggc tac ata tta gat gag atg aga aga aaa tct gct gct       1104
Ala Ser Val Gly Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Ala           
        355                 360                 365                       

aaa ggg tta gaa acc tat gga gag gga tta gag tgg ggt gtc tta ctt       1152
Lys Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu           
    370                 375                 380                           

ggt ttt ggt cca ggg ata act gtt gaa act atc ctt ctt cac agc ctg       1200
Gly Phe Gly Pro Gly Ile Thr Val Glu Thr Ile Leu Leu His Ser Leu           
385                 390                 395                 400           

cct ctc atg taa                                                       1212
Pro Leu Met                                                               
                                                                          


<210>  6
<211>  403
<212>  PRT
<213>  Aloe arborescens

<400>  6

Met Ser Ser Leu Ser Asn Ser Leu Pro Leu Met Glu Asp Val Gln Gly 
1               5                   10                  15      


Ile Arg Lys Ala Gln Lys Ala Asp Gly Thr Ala Thr Val Met Ala Ile 
            20                  25                  30          


Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp 
        35                  40                  45              


Val Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys 
    50                  55                  60                  


Lys Phe Asp His Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe 
65                  70                  75                  80  


Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Tyr 
                85                  90                  95      


Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val 
            100                 105                 110         


Pro Ala Leu Gly Thr Glu Ala Ala Val Lys Ala Ile Glu Glu Trp Gly 
        115                 120                 125             


Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly 
    130                 135                 140                 


Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu 
145                 150                 155                 160 


His Ala Asn Val Asn Lys Tyr Cys Ile Tyr Met Gln Gly Cys Tyr Ala 
                165                 170                 175     


Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg 
            180                 185                 190         


Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Met Met Leu 
        195                 200                 205             


Arg Ala Pro Asn Glu Thr His Leu Asp Asn Ala Ile Gly Ile Ser Leu 
    210                 215                 220                 


Phe Gly Asp Gly Ala Ala Ala Leu Ile Ile Gly Ser Asp Pro Ile Ile 
225                 230                 235                 240 


Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Thr Lys Gln Thr Val 
                245                 250                 255     


Ile Pro Asn Thr Glu Asp Val Ile His Leu His Leu Arg Glu Thr Gly 
            260                 265                 270         


Met Met Phe Tyr Leu Ser Lys Gly Ser Pro Met Thr Ile Ser Asn Asn 
        275                 280                 285             


Val Glu Ala Cys Leu Ile Asp Val Phe Lys Ser Val Gly Ile Thr Pro 
    290                 295                 300                 


Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg 
305                 310                 315                 320 


Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys 
                325                 330                 335     


Phe Arg Ala Ala Arg Thr Val Leu Trp Asp Tyr Gly Asn Met Val Ser 
            340                 345                 350         


Ala Ser Val Gly Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Ala 
        355                 360                 365             


Lys Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu 
    370                 375                 380                 


Gly Phe Gly Pro Gly Ile Thr Val Glu Thr Ile Leu Leu His Ser Leu 
385                 390                 395                 400 


Pro Leu Met 
            


<210>  7
<211>  1338
<212>  DNA
<213>  Neurospora crassa


<220>
<221>  CDS
<222>  (1)..(1338)
<223>  ORAS gene (GenBank ID number XM_955334.2 position 582 to 1919) 
       encoding a Type III pentaketide synthase (GenBank ID number 
       EGZ68458)

<400>  7
atg gct gct tca act gtt gcc ggg gag ctg ggg ctc tcc atc acg ggc         48
Met Ala Ala Ser Thr Val Ala Gly Glu Leu Gly Leu Ser Ile Thr Gly           
1               5                   10                  15                

ttg gga gtc cag tat cct cca tac agc ctt ggt cca gac gct atc gac         96
Leu Gly Val Gln Tyr Pro Pro Tyr Ser Leu Gly Pro Asp Ala Ile Asp           
            20                  25                  30                    

att ctc agc aag aga tac cac cca gag tcc cca gcc atg aag aag gtc        144
Ile Leu Ser Lys Arg Tyr His Pro Glu Ser Pro Ala Met Lys Lys Val           
        35                  40                  45                        

ctc gcc atc aac cga tac acg ggc att gat cag cgc tcc tcg ata gga        192
Leu Ala Ile Asn Arg Tyr Thr Gly Ile Asp Gln Arg Ser Ser Ile Gly           
    50                  55                  60                            

aac cct gac cac ccg ctc gtg aac aag ccc aac cca cct acc gtc aaa        240
Asn Pro Asp His Pro Leu Val Asn Lys Pro Asn Pro Pro Thr Val Lys           
65                  70                  75                  80            

gaa ctt cat gag gtc ttc atg tcc gat ggt gtc cct ctt gct gta gaa        288
Glu Leu His Glu Val Phe Met Ser Asp Gly Val Pro Leu Ala Val Glu           
                85                  90                  95                

gcc tcg cga aag gct atg gcc gaa gcg cgg cta gta ccg gct cag atc        336
Ala Ser Arg Lys Ala Met Ala Glu Ala Arg Leu Val Pro Ala Gln Ile           
            100                 105                 110                   

aca cac atg gtc tcg acg aca tgc acc gac tcg gcc aac ccg ggc tac        384
Thr His Met Val Ser Thr Thr Cys Thr Asp Ser Ala Asn Pro Gly Tyr           
        115                 120                 125                       

gac cat tac gtc gca aaa gag ctc ggt ctc agt gac cgc ctg gag aag        432
Asp His Tyr Val Ala Lys Glu Leu Gly Leu Ser Asp Arg Leu Glu Lys           
    130                 135                 140                           

gtc ctc ctc cac ggc atc ggc tgc agt ggt ggt ctc gcc gcc ctt cgc        480
Val Leu Leu His Gly Ile Gly Cys Ser Gly Gly Leu Ala Ala Leu Arg           
145                 150                 155                 160           

aca gcg gcg aat ctc tgt ctg ggc cac aca gcg cgc ggc aag cca gcc        528
Thr Ala Ala Asn Leu Cys Leu Gly His Thr Ala Arg Gly Lys Pro Ala           
                165                 170                 175               

cgg att ctg gtc ctc gcg ctc gaa gtc tcc acg acc atg gtc cgc agc        576
Arg Ile Leu Val Leu Ala Leu Glu Val Ser Thr Thr Met Val Arg Ser           
            180                 185                 190                   

gag cta gaa agc atc gac gct ttg caa gaa acg cgc att ggc atc gcc        624
Glu Leu Glu Ser Ile Asp Ala Leu Gln Glu Thr Arg Ile Gly Ile Ala           
        195                 200                 205                       

ttg ttc agc gac tgc gct agc gcc gtg atc ctg tcc aac ggc atc ggc        672
Leu Phe Ser Asp Cys Ala Ser Ala Val Ile Leu Ser Asn Gly Ile Gly           
    210                 215                 220                           

gag gca ccg ggc aag ccc gcg atc tac gac ctc ttg ggt tgg gaa aac        720
Glu Ala Pro Gly Lys Pro Ala Ile Tyr Asp Leu Leu Gly Trp Glu Asn           
225                 230                 235                 240           

cgc gtg atc ccg gac tcc gaa cac gac ctc ggc ttc gac gtc gac cca        768
Arg Val Ile Pro Asp Ser Glu His Asp Leu Gly Phe Asp Val Asp Pro           
                245                 250                 255               

atg ggg tgg aaa gtc gtc ttg tcg ccc cga gtc cca gta cta gcc aaa        816
Met Gly Trp Lys Val Val Leu Ser Pro Arg Val Pro Val Leu Ala Lys           
            260                 265                 270                   

gcc tcc ctc caa cca acc tac gcc gac ctc cta tcc tct ctc caa gac        864
Ala Ser Leu Gln Pro Thr Tyr Ala Asp Leu Leu Ser Ser Leu Gln Asp           
        275                 280                 285                       

caa ctc cct tcg tcg tac cag aaa cct gcc gat ttc gac tgg gca atg        912
Gln Leu Pro Ser Ser Tyr Gln Lys Pro Ala Asp Phe Asp Trp Ala Met           
    290                 295                 300                           

cac ccc ggc ggc gcc acc atc ctg tcc ggc gcc gaa agc gcc atg ggt        960
His Pro Gly Gly Ala Thr Ile Leu Ser Gly Ala Glu Ser Ala Met Gly           
305                 310                 315                 320           

ttg aca cca gag cac atg cgc gcc tcc tac gac agg tac atc aac cac       1008
Leu Thr Pro Glu His Met Arg Ala Ser Tyr Asp Arg Tyr Ile Asn His           
                325                 330                 335               

ggc aac tcg agc tcc gca acc atc ttc agc gtt ctc aac cgg ctc agg       1056
Gly Asn Ser Ser Ser Ala Thr Ile Phe Ser Val Leu Asn Arg Leu Arg           
            340                 345                 350                   

gaa aag gac atg gat gca ctg gcg ccc ggc ggc aaa gta aag gag tat       1104
Glu Lys Asp Met Asp Ala Leu Ala Pro Gly Gly Lys Val Lys Glu Tyr           
        355                 360                 365                       

gtc gtc ggt tgc gcg ttc gga ccg ggg atc aac gtc gag atg tgt atg       1152
Val Val Gly Cys Ala Phe Gly Pro Gly Ile Asn Val Glu Met Cys Met           
    370                 375                 380                           

ttg aag cgg aga atg aac gcg cca gca agg acg acg acg ggt ttg gac       1200
Leu Lys Arg Arg Met Asn Ala Pro Ala Arg Thr Thr Thr Gly Leu Asp           
385                 390                 395                 400           

aca ccg ccg gag acg gat gat agc gag ggg ccg ggg ccg ggg tcg agt       1248
Thr Pro Pro Glu Thr Asp Asp Ser Glu Gly Pro Gly Pro Gly Ser Ser           
                405                 410                 415               

gcg ggg agt gac gat ggg gag tcg ata gaa ggg ggc gag aag gag gag       1296
Ala Gly Ser Asp Asp Gly Glu Ser Ile Glu Gly Gly Glu Lys Glu Glu           
            420                 425                 430                   

aag ttt att aat gag gcg ttg gac aat gtt gaa ctg gat tga               1338
Lys Phe Ile Asn Glu Ala Leu Asp Asn Val Glu Leu Asp                       
        435                 440                 445                       


<210>  8
<211>  445
<212>  PRT
<213>  Neurospora crassa

<400>  8

Met Ala Ala Ser Thr Val Ala Gly Glu Leu Gly Leu Ser Ile Thr Gly 
1               5                   10                  15      


Leu Gly Val Gln Tyr Pro Pro Tyr Ser Leu Gly Pro Asp Ala Ile Asp 
            20                  25                  30          


Ile Leu Ser Lys Arg Tyr His Pro Glu Ser Pro Ala Met Lys Lys Val 
        35                  40                  45              


Leu Ala Ile Asn Arg Tyr Thr Gly Ile Asp Gln Arg Ser Ser Ile Gly 
    50                  55                  60                  


Asn Pro Asp His Pro Leu Val Asn Lys Pro Asn Pro Pro Thr Val Lys 
65                  70                  75                  80  


Glu Leu His Glu Val Phe Met Ser Asp Gly Val Pro Leu Ala Val Glu 
                85                  90                  95      


Ala Ser Arg Lys Ala Met Ala Glu Ala Arg Leu Val Pro Ala Gln Ile 
            100                 105                 110         


Thr His Met Val Ser Thr Thr Cys Thr Asp Ser Ala Asn Pro Gly Tyr 
        115                 120                 125             


Asp His Tyr Val Ala Lys Glu Leu Gly Leu Ser Asp Arg Leu Glu Lys 
    130                 135                 140                 


Val Leu Leu His Gly Ile Gly Cys Ser Gly Gly Leu Ala Ala Leu Arg 
145                 150                 155                 160 


Thr Ala Ala Asn Leu Cys Leu Gly His Thr Ala Arg Gly Lys Pro Ala 
                165                 170                 175     


Arg Ile Leu Val Leu Ala Leu Glu Val Ser Thr Thr Met Val Arg Ser 
            180                 185                 190         


Glu Leu Glu Ser Ile Asp Ala Leu Gln Glu Thr Arg Ile Gly Ile Ala 
        195                 200                 205             


Leu Phe Ser Asp Cys Ala Ser Ala Val Ile Leu Ser Asn Gly Ile Gly 
    210                 215                 220                 


Glu Ala Pro Gly Lys Pro Ala Ile Tyr Asp Leu Leu Gly Trp Glu Asn 
225                 230                 235                 240 


Arg Val Ile Pro Asp Ser Glu His Asp Leu Gly Phe Asp Val Asp Pro 
                245                 250                 255     


Met Gly Trp Lys Val Val Leu Ser Pro Arg Val Pro Val Leu Ala Lys 
            260                 265                 270         


Ala Ser Leu Gln Pro Thr Tyr Ala Asp Leu Leu Ser Ser Leu Gln Asp 
        275                 280                 285             


Gln Leu Pro Ser Ser Tyr Gln Lys Pro Ala Asp Phe Asp Trp Ala Met 
    290                 295                 300                 


His Pro Gly Gly Ala Thr Ile Leu Ser Gly Ala Glu Ser Ala Met Gly 
305                 310                 315                 320 


Leu Thr Pro Glu His Met Arg Ala Ser Tyr Asp Arg Tyr Ile Asn His 
                325                 330                 335     


Gly Asn Ser Ser Ser Ala Thr Ile Phe Ser Val Leu Asn Arg Leu Arg 
            340                 345                 350         


Glu Lys Asp Met Asp Ala Leu Ala Pro Gly Gly Lys Val Lys Glu Tyr 
        355                 360                 365             


Val Val Gly Cys Ala Phe Gly Pro Gly Ile Asn Val Glu Met Cys Met 
    370                 375                 380                 


Leu Lys Arg Arg Met Asn Ala Pro Ala Arg Thr Thr Thr Gly Leu Asp 
385                 390                 395                 400 


Thr Pro Pro Glu Thr Asp Asp Ser Glu Gly Pro Gly Pro Gly Ser Ser 
                405                 410                 415     


Ala Gly Ser Asp Asp Gly Glu Ser Ile Glu Gly Gly Glu Lys Glu Glu 
            420                 425                 430         


Lys Phe Ile Asn Glu Ala Leu Asp Asn Val Glu Leu Asp 
        435                 440                 445 


<210>  9
<211>  1050
<212>  DNA
<213>  Streptomyces fulvissimus


<220>
<221>  CDS
<222>  (1)..(1050)
<223>  1,3,6,8-tetrahydroxynaphthalene synthase gene [GenBank ID number 
       CP005080 position 7775934 to 7776986)encoding a Type III 
       pentaketide synthase (GenBank ID number AGK81780)

<400>  9
atg acc cgg atc gcc gcg gtc cac ggg gcc ctg ccg ccc cac cgc cac         48
Met Thr Arg Ile Ala Ala Val His Gly Ala Leu Pro Pro His Arg His           
1               5                   10                  15                

acc cag cca gag gtc acc gac atg gtg gcc gac acc tgt ctg ccg ccc         96
Thr Gln Pro Glu Val Thr Asp Met Val Ala Asp Thr Cys Leu Pro Pro           
            20                  25                  30                    

ggc gcc gac cgc cgc gtc ctg gac cgg ctc cac gag aac gcc cgc gtc        144
Gly Ala Asp Arg Arg Val Leu Asp Arg Leu His Glu Asn Ala Arg Val           
        35                  40                  45                        

cgc acc cgg cac acc gtg ctg ccg ctc gac gga tac cgt gac ctg gac        192
Arg Thr Arg His Thr Val Leu Pro Leu Asp Gly Tyr Arg Asp Leu Asp           
    50                  55                  60                            

ggc ttc ggc gcc gcc aac gac gtg ttc atc cgc tcg gcc gtc gac ctc        240
Gly Phe Gly Ala Ala Asn Asp Val Phe Ile Arg Ser Ala Val Asp Leu           
65                  70                  75                  80            

ggc ggc cag gcc gta cgc ggc gca ctg cgg gcg gcg ggg ctg cgg ccc        288
Gly Gly Gln Ala Val Arg Gly Ala Leu Arg Ala Ala Gly Leu Arg Pro           
                85                  90                  95                

acc gat gtg gac ctg ctg atg ttc acc tcc gtc acc ggt atc gcg gcc        336
Thr Asp Val Asp Leu Leu Met Phe Thr Ser Val Thr Gly Ile Ala Ala           
            100                 105                 110                   

ccc tcc gtc gac gcc cgg ctg gtg gcc cgc ctc ggc ctg cgg tcc gac        384
Pro Ser Val Asp Ala Arg Leu Val Ala Arg Leu Gly Leu Arg Ser Asp           
        115                 120                 125                       

gtg aaa cgg ctg ccg gtc ttc ggc ctc ggc tgt gtc gcc gga gcg gcc        432
Val Lys Arg Leu Pro Val Phe Gly Leu Gly Cys Val Ala Gly Ala Ala           
    130                 135                 140                           

ggc gtg gcc cgg atc cac gac tac ctg ctc ggc cac ccg gac gac gtc        480
Gly Val Ala Arg Ile His Asp Tyr Leu Leu Gly His Pro Asp Asp Val           
145                 150                 155                 160           

gcc gtg ctc ctc tcg gtc gaa ctg tgc tcc ctc acc ttc cag cgc cac        528
Ala Val Leu Leu Ser Val Glu Leu Cys Ser Leu Thr Phe Gln Arg His           
                165                 170                 175               

gac gtg acg ccc gcc aac ctg gtg gcc acc gcc ctc ttc ggc gac ggg        576
Asp Val Thr Pro Ala Asn Leu Val Ala Thr Ala Leu Phe Gly Asp Gly           
            180                 185                 190                   

gcc gcc gcg gtg gtc gcc ctc ggc ggg cga cgg gcc gtc tcc gga ccc        624
Ala Ala Ala Val Val Ala Leu Gly Gly Arg Arg Ala Val Ser Gly Pro           
        195                 200                 205                       

gag atc gtg gcc acc cgc agc cgg atg tac ccc gag acc gag cac gtg        672
Glu Ile Val Ala Thr Arg Ser Arg Met Tyr Pro Glu Thr Glu His Val           
    210                 215                 220                           

atg ggc tgg tcc gtc ggc tcc acc gga ttc agc gtg gtc ctc gat ccg        720
Met Gly Trp Ser Val Gly Ser Thr Gly Phe Ser Val Val Leu Asp Pro           
225                 230                 235                 240           

gcc gtg ccc gac gtc gta cgc cag tac ctc gcc gac gac gta cgg gag        768
Ala Val Pro Asp Val Val Arg Gln Tyr Leu Ala Asp Asp Val Arg Glu           
                245                 250                 255               

ttc ctc gcc gaa cac ggc ctc aaa ccg aag gac atc gcc cac tgg gtc        816
Phe Leu Ala Glu His Gly Leu Lys Pro Lys Asp Ile Ala His Trp Val           
            260                 265                 270                   

tgc cac ccg ggc ggg ccc aag gtc ctg gag acc gtc acc gag gtc ctc        864
Cys His Pro Gly Gly Pro Lys Val Leu Glu Thr Val Thr Glu Val Leu           
        275                 280                 285                       

gac ctg ccc gac ggg gcg ctc gac gtc acc tgg cgc tcg ctg gcc gac        912
Asp Leu Pro Asp Gly Ala Leu Asp Val Thr Trp Arg Ser Leu Ala Asp           
    290                 295                 300                           

gtc ggc aac ctg tcc tcg tcc tcg gtc ctg cac gtc ctg cgg gac acc        960
Val Gly Asn Leu Ser Ser Ser Ser Val Leu His Val Leu Arg Asp Thr           
305                 310                 315                 320           

ctc gaa cac cgc cga ccc gaa ccg ggc acc cct ggg ctc ctg ctg gcc       1008
Leu Glu His Arg Arg Pro Glu Pro Gly Thr Pro Gly Leu Leu Leu Ala           
                325                 330                 335               

atg ggc ccc ggc ttc tgc tgc gaa ctg gtg ctg ctg cgc tgg               1050
Met Gly Pro Gly Phe Cys Cys Glu Leu Val Leu Leu Arg Trp                   
            340                 345                 350                   


<210>  10
<211>  350
<212>  PRT
<213>  Streptomyces fulvissimus

<400>  10

Met Thr Arg Ile Ala Ala Val His Gly Ala Leu Pro Pro His Arg His 
1               5                   10                  15      


Thr Gln Pro Glu Val Thr Asp Met Val Ala Asp Thr Cys Leu Pro Pro 
            20                  25                  30          


Gly Ala Asp Arg Arg Val Leu Asp Arg Leu His Glu Asn Ala Arg Val 
        35                  40                  45              


Arg Thr Arg His Thr Val Leu Pro Leu Asp Gly Tyr Arg Asp Leu Asp 
    50                  55                  60                  


Gly Phe Gly Ala Ala Asn Asp Val Phe Ile Arg Ser Ala Val Asp Leu 
65                  70                  75                  80  


Gly Gly Gln Ala Val Arg Gly Ala Leu Arg Ala Ala Gly Leu Arg Pro 
                85                  90                  95      


Thr Asp Val Asp Leu Leu Met Phe Thr Ser Val Thr Gly Ile Ala Ala 
            100                 105                 110         


Pro Ser Val Asp Ala Arg Leu Val Ala Arg Leu Gly Leu Arg Ser Asp 
        115                 120                 125             


Val Lys Arg Leu Pro Val Phe Gly Leu Gly Cys Val Ala Gly Ala Ala 
    130                 135                 140                 


Gly Val Ala Arg Ile His Asp Tyr Leu Leu Gly His Pro Asp Asp Val 
145                 150                 155                 160 


Ala Val Leu Leu Ser Val Glu Leu Cys Ser Leu Thr Phe Gln Arg His 
                165                 170                 175     


Asp Val Thr Pro Ala Asn Leu Val Ala Thr Ala Leu Phe Gly Asp Gly 
            180                 185                 190         


Ala Ala Ala Val Val Ala Leu Gly Gly Arg Arg Ala Val Ser Gly Pro 
        195                 200                 205             


Glu Ile Val Ala Thr Arg Ser Arg Met Tyr Pro Glu Thr Glu His Val 
    210                 215                 220                 


Met Gly Trp Ser Val Gly Ser Thr Gly Phe Ser Val Val Leu Asp Pro 
225                 230                 235                 240 


Ala Val Pro Asp Val Val Arg Gln Tyr Leu Ala Asp Asp Val Arg Glu 
                245                 250                 255     


Phe Leu Ala Glu His Gly Leu Lys Pro Lys Asp Ile Ala His Trp Val 
            260                 265                 270         


Cys His Pro Gly Gly Pro Lys Val Leu Glu Thr Val Thr Glu Val Leu 
        275                 280                 285             


Asp Leu Pro Asp Gly Ala Leu Asp Val Thr Trp Arg Ser Leu Ala Asp 
    290                 295                 300                 


Val Gly Asn Leu Ser Ser Ser Ser Val Leu His Val Leu Arg Asp Thr 
305                 310                 315                 320 


Leu Glu His Arg Arg Pro Glu Pro Gly Thr Pro Gly Leu Leu Leu Ala 
                325                 330                 335     


Met Gly Pro Gly Phe Cys Cys Glu Leu Val Leu Leu Arg Trp 
            340                 345                 350 


<210>  11
<211>  1191
<212>  DNA
<213>  Plumbago indica


<220>
<221>  CDS
<222>  (1)..(1191)
<223>  PinPKS gene [GenBank ID number AB259100) encoding Type III 
       hexaketide synthase  (GenBank ID number BAF44539)

<400>  11
atg gca cca gca gtt caa tct caa tct cac ggt gga gca tac cgc agc         48
Met Ala Pro Ala Val Gln Ser Gln Ser His Gly Gly Ala Tyr Arg Ser           
1               5                   10                  15                

aat ggt gag agg tca aaa ggg cca gcg acc gtg cta gcc att gct act         96
Asn Gly Glu Arg Ser Lys Gly Pro Ala Thr Val Leu Ala Ile Ala Thr           
            20                  25                  30                    

gct gtg cca cca aat gta tac tat cag gat gaa tat gcc gac ttt ttc        144
Ala Val Pro Pro Asn Val Tyr Tyr Gln Asp Glu Tyr Ala Asp Phe Phe           
        35                  40                  45                        

ttc cgc gtc acc aac agc gag cac aag act gcg atc aag gag aag ttt        192
Phe Arg Val Thr Asn Ser Glu His Lys Thr Ala Ile Lys Glu Lys Phe           
    50                  55                  60                            

aac cga gtt tgc ggt acc tcg atg att aag aag agg cac atg tac ttc        240
Asn Arg Val Cys Gly Thr Ser Met Ile Lys Lys Arg His Met Tyr Phe           
65                  70                  75                  80            

acc gag aag atg ctt aac caa aac aaa aac atg tgc acc tgg gat gat        288
Thr Glu Lys Met Leu Asn Gln Asn Lys Asn Met Cys Thr Trp Asp Asp           
                85                  90                  95                

aaa tcc ctc aac gcc cgt cag gac atg gtg atc cca gca gtc ccc gag        336
Lys Ser Leu Asn Ala Arg Gln Asp Met Val Ile Pro Ala Val Pro Glu           
            100                 105                 110                   

ctc ggc aaa gaa gcc gcc ttg aag gcc atc gag gag tgg gga aaa cca        384
Leu Gly Lys Glu Ala Ala Leu Lys Ala Ile Glu Glu Trp Gly Lys Pro           
        115                 120                 125                       

ctc tct aac atc acc cac ctc atc ttc tgc acc aca gcc ggt aac gac        432
Leu Ser Asn Ile Thr His Leu Ile Phe Cys Thr Thr Ala Gly Asn Asp           
    130                 135                 140                           

gcc cct gga gca gac ttc agg cta acc cag ctc ctt gga ctg aac cca        480
Ala Pro Gly Ala Asp Phe Arg Leu Thr Gln Leu Leu Gly Leu Asn Pro           
145                 150                 155                 160           

tca gtg aac cgg tac atg atc tac cag cag gga tgc ttc gct gga gcc        528
Ser Val Asn Arg Tyr Met Ile Tyr Gln Gln Gly Cys Phe Ala Gly Ala           
                165                 170                 175               

acc gca ctc cgc ata gcc aag gac ctt gct gag aac aac aag ggt gct        576
Thr Ala Leu Arg Ile Ala Lys Asp Leu Ala Glu Asn Asn Lys Gly Ala           
            180                 185                 190                   

cgt gtg ctc att gta tgc tgt gag atc ttt gct ttt gca ttc cgt gga        624
Arg Val Leu Ile Val Cys Cys Glu Ile Phe Ala Phe Ala Phe Arg Gly           
        195                 200                 205                       

cct cat gag gac cac atg gac tct ttg att tgc cag ctg ctg ttt ggg        672
Pro His Glu Asp His Met Asp Ser Leu Ile Cys Gln Leu Leu Phe Gly           
    210                 215                 220                           

gat ggt gca gct gct gtc att gtc ggt ggt gat cct gac gag acc gag        720
Asp Gly Ala Ala Ala Val Ile Val Gly Gly Asp Pro Asp Glu Thr Glu           
225                 230                 235                 240           

aat gca ctc ttt gag ctc gag tgg gcc aac tca acc atc ata cca caa        768
Asn Ala Leu Phe Glu Leu Glu Trp Ala Asn Ser Thr Ile Ile Pro Gln           
                245                 250                 255               

tca gaa gag gcc atc acc ctt aga atg cgc gaa gaa ggt ctc atg atc        816
Ser Glu Glu Ala Ile Thr Leu Arg Met Arg Glu Glu Gly Leu Met Ile           
            260                 265                 270                   

ggt ttg tcc aag gaa atc cca agg ctc cta ggc gaa cag atc gaa gac        864
Gly Leu Ser Lys Glu Ile Pro Arg Leu Leu Gly Glu Gln Ile Glu Asp           
        275                 280                 285                       

att ttg gtc gag gct ttc aca ccc ctt gga att act gac tgg agc tca        912
Ile Leu Val Glu Ala Phe Thr Pro Leu Gly Ile Thr Asp Trp Ser Ser           
    290                 295                 300                           

ctc ttc tgg att gcc cac cca ggt ggt aag gcc atc ctt gag gca ctg        960
Leu Phe Trp Ile Ala His Pro Gly Gly Lys Ala Ile Leu Glu Ala Leu           
305                 310                 315                 320           

gag aag aaa atc ggc gtt gaa ggt aag ttg tgg gct tcg tgg cac gtt       1008
Glu Lys Lys Ile Gly Val Glu Gly Lys Leu Trp Ala Ser Trp His Val           
                325                 330                 335               

ctt aaa gaa tat gga aac ttg acc agt gct tgt gtg ctg ttc gcc atg       1056
Leu Lys Glu Tyr Gly Asn Leu Thr Ser Ala Cys Val Leu Phe Ala Met           
            340                 345                 350                   

gac gaa atg agg aag agg tcc att aag gaa ggg aag gcc act act gga       1104
Asp Glu Met Arg Lys Arg Ser Ile Lys Glu Gly Lys Ala Thr Thr Gly           
        355                 360                 365                       

gac gga cac gaa tat ggt gtt ctc ttc ggt gtc ggc ccg ggt ctt acc       1152
Asp Gly His Glu Tyr Gly Val Leu Phe Gly Val Gly Pro Gly Leu Thr           
    370                 375                 380                           

gtc gag aca gtt gtg cta aaa agt gtg ccg ctt aac taa                   1191
Val Glu Thr Val Val Leu Lys Ser Val Pro Leu Asn                           
385                 390                 395                               


<210>  12
<211>  396
<212>  PRT
<213>  Plumbago indica

<400>  12

Met Ala Pro Ala Val Gln Ser Gln Ser His Gly Gly Ala Tyr Arg Ser 
1               5                   10                  15      


Asn Gly Glu Arg Ser Lys Gly Pro Ala Thr Val Leu Ala Ile Ala Thr 
            20                  25                  30          


Ala Val Pro Pro Asn Val Tyr Tyr Gln Asp Glu Tyr Ala Asp Phe Phe 
        35                  40                  45              


Phe Arg Val Thr Asn Ser Glu His Lys Thr Ala Ile Lys Glu Lys Phe 
    50                  55                  60                  


Asn Arg Val Cys Gly Thr Ser Met Ile Lys Lys Arg His Met Tyr Phe 
65                  70                  75                  80  


Thr Glu Lys Met Leu Asn Gln Asn Lys Asn Met Cys Thr Trp Asp Asp 
                85                  90                  95      


Lys Ser Leu Asn Ala Arg Gln Asp Met Val Ile Pro Ala Val Pro Glu 
            100                 105                 110         


Leu Gly Lys Glu Ala Ala Leu Lys Ala Ile Glu Glu Trp Gly Lys Pro 
        115                 120                 125             


Leu Ser Asn Ile Thr His Leu Ile Phe Cys Thr Thr Ala Gly Asn Asp 
    130                 135                 140                 


Ala Pro Gly Ala Asp Phe Arg Leu Thr Gln Leu Leu Gly Leu Asn Pro 
145                 150                 155                 160 


Ser Val Asn Arg Tyr Met Ile Tyr Gln Gln Gly Cys Phe Ala Gly Ala 
                165                 170                 175     


Thr Ala Leu Arg Ile Ala Lys Asp Leu Ala Glu Asn Asn Lys Gly Ala 
            180                 185                 190         


Arg Val Leu Ile Val Cys Cys Glu Ile Phe Ala Phe Ala Phe Arg Gly 
        195                 200                 205             


Pro His Glu Asp His Met Asp Ser Leu Ile Cys Gln Leu Leu Phe Gly 
    210                 215                 220                 


Asp Gly Ala Ala Ala Val Ile Val Gly Gly Asp Pro Asp Glu Thr Glu 
225                 230                 235                 240 


Asn Ala Leu Phe Glu Leu Glu Trp Ala Asn Ser Thr Ile Ile Pro Gln 
                245                 250                 255     


Ser Glu Glu Ala Ile Thr Leu Arg Met Arg Glu Glu Gly Leu Met Ile 
            260                 265                 270         


Gly Leu Ser Lys Glu Ile Pro Arg Leu Leu Gly Glu Gln Ile Glu Asp 
        275                 280                 285             


Ile Leu Val Glu Ala Phe Thr Pro Leu Gly Ile Thr Asp Trp Ser Ser 
    290                 295                 300                 


Leu Phe Trp Ile Ala His Pro Gly Gly Lys Ala Ile Leu Glu Ala Leu 
305                 310                 315                 320 


Glu Lys Lys Ile Gly Val Glu Gly Lys Leu Trp Ala Ser Trp His Val 
                325                 330                 335     


Leu Lys Glu Tyr Gly Asn Leu Thr Ser Ala Cys Val Leu Phe Ala Met 
            340                 345                 350         


Asp Glu Met Arg Lys Arg Ser Ile Lys Glu Gly Lys Ala Thr Thr Gly 
        355                 360                 365             


Asp Gly His Glu Tyr Gly Val Leu Phe Gly Val Gly Pro Gly Leu Thr 
    370                 375                 380                 


Val Glu Thr Val Val Leu Lys Ser Val Pro Leu Asn 
385                 390                 395     


<210>  13
<211>  1170
<212>  DNA
<213>  Drosophyllum lusitanicum


<220>
<221>  CDS
<222>  (1)..(1170)
<223>  DluHKS gene [GenBank ID number EF405822) encoding Type III 
       hexaketide synthase ( GenBank ID number ABQ59603)

<400>  13
atg gca ttt gtg gag gga atg ggg aag aag gca gag gga cca gcc acc         48
Met Ala Phe Val Glu Gly Met Gly Lys Lys Ala Glu Gly Pro Ala Thr           
1               5                   10                  15                

atc ttg gcc atc ggc aca gct gtt cca ccc aac tgc aac ata caa gcc         96
Ile Leu Ala Ile Gly Thr Ala Val Pro Pro Asn Cys Asn Ile Gln Ala           
            20                  25                  30                    

gac ttc cca gac tac tat ttc agg gtc aca aac agc gag cat atg act        144
Asp Phe Pro Asp Tyr Tyr Phe Arg Val Thr Asn Ser Glu His Met Thr           
        35                  40                  45                        

gat tta aag gaa aaa ttc aag cgc att tgt gag aag acc gca att aaa        192
Asp Leu Lys Glu Lys Phe Lys Arg Ile Cys Glu Lys Thr Ala Ile Lys           
    50                  55                  60                            

aaa cgt tac acc tac ttg act gag gaa atg atc aag gag aat ccg ggg        240
Lys Arg Tyr Thr Tyr Leu Thr Glu Glu Met Ile Lys Glu Asn Pro Gly           
65                  70                  75                  80            

atc ggg act ttc aat ggt tta tct ttg aat gcg cgt caa gaa atg gtg        288
Ile Gly Thr Phe Asn Gly Leu Ser Leu Asn Ala Arg Gln Glu Met Val           
                85                  90                  95                

atc gcc gaa acc ccg agg cta ggg aaa gaa gcg gct cta aaa gct ctc        336
Ile Ala Glu Thr Pro Arg Leu Gly Lys Glu Ala Ala Leu Lys Ala Leu           
            100                 105                 110                   

aaa gaa tgg ggt cag ccc aaa tcg aga ctc act cac ctc atc ttc tgt        384
Lys Glu Trp Gly Gln Pro Lys Ser Arg Leu Thr His Leu Ile Phe Cys           
        115                 120                 125                       

tcc act gcc gga gtc gac atg cct ggt tgt gat tat cag ctc acc aaa        432
Ser Thr Ala Gly Val Asp Met Pro Gly Cys Asp Tyr Gln Leu Thr Lys           
    130                 135                 140                           

atg ctc ggt ctg aac cct act atc aat aga cta atg atc tac caa caa        480
Met Leu Gly Leu Asn Pro Thr Ile Asn Arg Leu Met Ile Tyr Gln Gln           
145                 150                 155                 160           

ggt tgt tat gct ggt ggc acg gtc ctc cgt atc gcc aag gat gtc gct        528
Gly Cys Tyr Ala Gly Gly Thr Val Leu Arg Ile Ala Lys Asp Val Ala           
                165                 170                 175               

gaa aac aac aag gga gca cgt gtt ctc gtg gtg tgc tct gaa atc aca        576
Glu Asn Asn Lys Gly Ala Arg Val Leu Val Val Cys Ser Glu Ile Thr           
            180                 185                 190                   

gca att ttt ttc cgc ggg cca tct gag cac cac atg gac tcc tta gtc        624
Ala Ile Phe Phe Arg Gly Pro Ser Glu His His Met Asp Ser Leu Val           
        195                 200                 205                       

ggc caa act ctt ttc ggc gac ggt gct gcc gcg ctg atc atc ggt tcc        672
Gly Gln Thr Leu Phe Gly Asp Gly Ala Ala Ala Leu Ile Ile Gly Ser           
    210                 215                 220                           

gac atg gac gag tcc atc gag aag ccg ttg tat cag ctt atc tcg gct        720
Asp Met Asp Glu Ser Ile Glu Lys Pro Leu Tyr Gln Leu Ile Ser Ala           
225                 230                 235                 240           

agt caa acc ctt gta ccg gac tcc gag aac gcg atg gct ttg cat ttg        768
Ser Gln Thr Leu Val Pro Asp Ser Glu Asn Ala Met Ala Leu His Leu           
                245                 250                 255               

aaa gaa gag ggt ctc acc ttc cac ctt tcg aag gat gtt ccc tca ttg        816
Lys Glu Glu Gly Leu Thr Phe His Leu Ser Lys Asp Val Pro Ser Leu           
            260                 265                 270                   

ata tcg aag aac ata gag gac gtc ttg gag gcc gct ttt aag cct ttg        864
Ile Ser Lys Asn Ile Glu Asp Val Leu Glu Ala Ala Phe Lys Pro Leu           
        275                 280                 285                       

ggt atc aac gac tgg aac tct cta ttt tac atc act cat ccc ggt ggt        912
Gly Ile Asn Asp Trp Asn Ser Leu Phe Tyr Ile Thr His Pro Gly Gly           
    290                 295                 300                           

agg gcg att cta gat ggg gtg gag aac aaa ctc ggt cta gac aag gat        960
Arg Ala Ile Leu Asp Gly Val Glu Asn Lys Leu Gly Leu Asp Lys Asp           
305                 310                 315                 320           

aaa atg aag gag agt cga tac gtg ctc agc gag tac ggt aat ttg aca       1008
Lys Met Lys Glu Ser Arg Tyr Val Leu Ser Glu Tyr Gly Asn Leu Thr           
                325                 330                 335               

gga gca tgt gtg ttg ttt atc tta gac gag atg agg aag cgg tcc atg       1056
Gly Ala Cys Val Leu Phe Ile Leu Asp Glu Met Arg Lys Arg Ser Met           
            340                 345                 350                   

gag gaa ggc aag tca acc acc ggc aag gga tcg gat ttc ggt gtt ttg       1104
Glu Glu Gly Lys Ser Thr Thr Gly Lys Gly Ser Asp Phe Gly Val Leu           
        355                 360                 365                       

ctt ggg ttt ggg cca ggt atc aca gtt gaa acc gtt gta ttg cga agc       1152
Leu Gly Phe Gly Pro Gly Ile Thr Val Glu Thr Val Val Leu Arg Ser           
    370                 375                 380                           

ttc cct ata aac aac taa                                               1170
Phe Pro Ile Asn Asn                                                       
385                                                                       


<210>  14
<211>  389
<212>  PRT
<213>  Drosophyllum lusitanicum

<400>  14

Met Ala Phe Val Glu Gly Met Gly Lys Lys Ala Glu Gly Pro Ala Thr 
1               5                   10                  15      


Ile Leu Ala Ile Gly Thr Ala Val Pro Pro Asn Cys Asn Ile Gln Ala 
            20                  25                  30          


Asp Phe Pro Asp Tyr Tyr Phe Arg Val Thr Asn Ser Glu His Met Thr 
        35                  40                  45              


Asp Leu Lys Glu Lys Phe Lys Arg Ile Cys Glu Lys Thr Ala Ile Lys 
    50                  55                  60                  


Lys Arg Tyr Thr Tyr Leu Thr Glu Glu Met Ile Lys Glu Asn Pro Gly 
65                  70                  75                  80  


Ile Gly Thr Phe Asn Gly Leu Ser Leu Asn Ala Arg Gln Glu Met Val 
                85                  90                  95      


Ile Ala Glu Thr Pro Arg Leu Gly Lys Glu Ala Ala Leu Lys Ala Leu 
            100                 105                 110         


Lys Glu Trp Gly Gln Pro Lys Ser Arg Leu Thr His Leu Ile Phe Cys 
        115                 120                 125             


Ser Thr Ala Gly Val Asp Met Pro Gly Cys Asp Tyr Gln Leu Thr Lys 
    130                 135                 140                 


Met Leu Gly Leu Asn Pro Thr Ile Asn Arg Leu Met Ile Tyr Gln Gln 
145                 150                 155                 160 


Gly Cys Tyr Ala Gly Gly Thr Val Leu Arg Ile Ala Lys Asp Val Ala 
                165                 170                 175     


Glu Asn Asn Lys Gly Ala Arg Val Leu Val Val Cys Ser Glu Ile Thr 
            180                 185                 190         


Ala Ile Phe Phe Arg Gly Pro Ser Glu His His Met Asp Ser Leu Val 
        195                 200                 205             


Gly Gln Thr Leu Phe Gly Asp Gly Ala Ala Ala Leu Ile Ile Gly Ser 
    210                 215                 220                 


Asp Met Asp Glu Ser Ile Glu Lys Pro Leu Tyr Gln Leu Ile Ser Ala 
225                 230                 235                 240 


Ser Gln Thr Leu Val Pro Asp Ser Glu Asn Ala Met Ala Leu His Leu 
                245                 250                 255     


Lys Glu Glu Gly Leu Thr Phe His Leu Ser Lys Asp Val Pro Ser Leu 
            260                 265                 270         


Ile Ser Lys Asn Ile Glu Asp Val Leu Glu Ala Ala Phe Lys Pro Leu 
        275                 280                 285             


Gly Ile Asn Asp Trp Asn Ser Leu Phe Tyr Ile Thr His Pro Gly Gly 
    290                 295                 300                 


Arg Ala Ile Leu Asp Gly Val Glu Asn Lys Leu Gly Leu Asp Lys Asp 
305                 310                 315                 320 


Lys Met Lys Glu Ser Arg Tyr Val Leu Ser Glu Tyr Gly Asn Leu Thr 
                325                 330                 335     


Gly Ala Cys Val Leu Phe Ile Leu Asp Glu Met Arg Lys Arg Ser Met 
            340                 345                 350         


Glu Glu Gly Lys Ser Thr Thr Gly Lys Gly Ser Asp Phe Gly Val Leu 
        355                 360                 365             


Leu Gly Phe Gly Pro Gly Ile Thr Val Glu Thr Val Val Leu Arg Ser 
    370                 375                 380                 


Phe Pro Ile Asn Asn 
385                 


<210>  15
<211>  1185
<212>  DNA
<213>  Plumbago zeylanica


<220>
<221>  CDS
<222>  (1)..(1176)
<223>  PzPKS gene [GenBank ID number JQ015381) encoding a Type III 
       hexaketide synthase (GenBank ID number AEX86944)

<400>  15
atg gca cca gca gtt caa tct gaa tct caa cgt gga gct tac cgc agc         48
Met Ala Pro Ala Val Gln Ser Glu Ser Gln Arg Gly Ala Tyr Arg Ser           
1               5                   10                  15                

aat ggt gag agg tca aag ggc cac gca acg gtg ctt gcc att gct act         96
Asn Gly Glu Arg Ser Lys Gly His Ala Thr Val Leu Ala Ile Ala Thr           
            20                  25                  30                    

gct gtg cca cca aat gta tac tat caa gat gaa tat gcc gac ttt ttc        144
Ala Val Pro Pro Asn Val Tyr Tyr Gln Asp Glu Tyr Ala Asp Phe Phe           
        35                  40                  45                        

ttc cgc gtc aca gac agc gag cac aag act gcg atc aag gag aag ttt        192
Phe Arg Val Thr Asp Ser Glu His Lys Thr Ala Ile Lys Glu Lys Phe           
    50                  55                  60                            

aac cga gtt tgt ggt acc tca atg atc aag aag agg cac atg tac ttc        240
Asn Arg Val Cys Gly Thr Ser Met Ile Lys Lys Arg His Met Tyr Phe           
65                  70                  75                  80            

acc gag aag atg ctg aac caa aac aaa aac atg tgc ccc tgg gac gat        288
Thr Glu Lys Met Leu Asn Gln Asn Lys Asn Met Cys Pro Trp Asp Asp           
                85                  90                  95                

aaa tcc ctc aac gcc cgt cag gac atg gtc atc cca gcg gtc ccc gag        336
Lys Ser Leu Asn Ala Arg Gln Asp Met Val Ile Pro Ala Val Pro Glu           
            100                 105                 110                   

ctc gga aaa gaa gcc gcc ttg aag gcc atc gaa gag tgg gga aaa cca        384
Leu Gly Lys Glu Ala Ala Leu Lys Ala Ile Glu Glu Trp Gly Lys Pro           
        115                 120                 125                       

ctg tct aac atc act cac ctc atc ttc tgc acc aca gcc ggt aac gac        432
Leu Ser Asn Ile Thr His Leu Ile Phe Cys Thr Thr Ala Gly Asn Asp           
    130                 135                 140                           

gct cct gga gcc gac ttc agg cta acc cag ctc ctt gga ctg aac cct        480
Ala Pro Gly Ala Asp Phe Arg Leu Thr Gln Leu Leu Gly Leu Asn Pro           
145                 150                 155                 160           

tca gtg aac cga tac atg atc tac cca cag gga tgc ttc gct gga gcc        528
Ser Val Asn Arg Tyr Met Ile Tyr Pro Gln Gly Cys Phe Ala Gly Ala           
                165                 170                 175               

acc gca ctc cgc ata ccc aag gac ctt gct gaa aac aac aag ggt gct        576
Thr Ala Leu Arg Ile Pro Lys Asp Leu Ala Glu Asn Asn Lys Gly Ala           
            180                 185                 190                   

cgg gtg ctc att gtg tgc tgt gaa atc ttt gca ttc cgt gga cct cat        624
Arg Val Leu Ile Val Cys Cys Glu Ile Phe Ala Phe Arg Gly Pro His           
        195                 200                 205                       

gag gac cac atg gac tct ttg att tgc cag ctt ctg ttt gga gat ggt        672
Glu Asp His Met Asp Ser Leu Ile Cys Gln Leu Leu Phe Gly Asp Gly           
    210                 215                 220                           

gca gct gct gtc att gtt ggt ggt gat cct gat gag acc gag aat tcg        720
Ala Ala Ala Val Ile Val Gly Gly Asp Pro Asp Glu Thr Glu Asn Ser           
225                 230                 235                 240           

ctc ttt gag ctc gag tgg gcc aac tca acc atc ata cca caa tca gaa        768
Leu Phe Glu Leu Glu Trp Ala Asn Ser Thr Ile Ile Pro Gln Ser Glu           
                245                 250                 255               

gag gcc atc acc ctt aaa atg cgc gaa gag ggt ctc atg atc ggt ctg        816
Glu Ala Ile Thr Leu Lys Met Arg Glu Glu Gly Leu Met Ile Gly Leu           
            260                 265                 270                   

tcc aag gaa atc cca agg ctc cta ggg gaa cag atc gaa gac att ttg        864
Ser Lys Glu Ile Pro Arg Leu Leu Gly Glu Gln Ile Glu Asp Ile Leu           
        275                 280                 285                       

gtc gag gct ttt gca ccc ctt gga att agc gac tgg agc tca ctc ttc        912
Val Glu Ala Phe Ala Pro Leu Gly Ile Ser Asp Trp Ser Ser Leu Phe           
    290                 295                 300                           

tgg att gct cac cca ggt ggt aag gca atc ctt gag gca ctc gag aag        960
Trp Ile Ala His Pro Gly Gly Lys Ala Ile Leu Glu Ala Leu Glu Lys           
305                 310                 315                 320           

aag atc ggt gtt gaa ggt aag ttg tgg gct tca tgg cac gtt ctt aaa       1008
Lys Ile Gly Val Glu Gly Lys Leu Trp Ala Ser Trp His Val Leu Lys           
                325                 330                 335               

gaa tat gga aac ttg acc agt gct tgt gtg ctc ttc gcc atg gac gag       1056
Glu Tyr Gly Asn Leu Thr Ser Ala Cys Val Leu Phe Ala Met Asp Glu           
            340                 345                 350                   

atg agg aag agg tcg att aag gaa ggg aag gcc act acc gga gac gga       1104
Met Arg Lys Arg Ser Ile Lys Glu Gly Lys Ala Thr Thr Gly Asp Gly           
        355                 360                 365                       

cac gac tac ggt gtt ctg ttc ggt gtc ggc ccg ggt ctt acc gtc gag       1152
His Asp Tyr Gly Val Leu Phe Gly Val Gly Pro Gly Leu Thr Val Glu           
    370                 375                 380                           

aca gtt gtg cta aaa agt gtg ccg cttaactaa                             1185
Thr Val Val Leu Lys Ser Val Pro                                           
385                 390                                                   


<210>  16
<211>  392
<212>  PRT
<213>  Plumbago zeylanica

<400>  16

Met Ala Pro Ala Val Gln Ser Glu Ser Gln Arg Gly Ala Tyr Arg Ser 
1               5                   10                  15      


Asn Gly Glu Arg Ser Lys Gly His Ala Thr Val Leu Ala Ile Ala Thr 
            20                  25                  30          


Ala Val Pro Pro Asn Val Tyr Tyr Gln Asp Glu Tyr Ala Asp Phe Phe 
        35                  40                  45              


Phe Arg Val Thr Asp Ser Glu His Lys Thr Ala Ile Lys Glu Lys Phe 
    50                  55                  60                  


Asn Arg Val Cys Gly Thr Ser Met Ile Lys Lys Arg His Met Tyr Phe 
65                  70                  75                  80  


Thr Glu Lys Met Leu Asn Gln Asn Lys Asn Met Cys Pro Trp Asp Asp 
                85                  90                  95      


Lys Ser Leu Asn Ala Arg Gln Asp Met Val Ile Pro Ala Val Pro Glu 
            100                 105                 110         


Leu Gly Lys Glu Ala Ala Leu Lys Ala Ile Glu Glu Trp Gly Lys Pro 
        115                 120                 125             


Leu Ser Asn Ile Thr His Leu Ile Phe Cys Thr Thr Ala Gly Asn Asp 
    130                 135                 140                 


Ala Pro Gly Ala Asp Phe Arg Leu Thr Gln Leu Leu Gly Leu Asn Pro 
145                 150                 155                 160 


Ser Val Asn Arg Tyr Met Ile Tyr Pro Gln Gly Cys Phe Ala Gly Ala 
                165                 170                 175     


Thr Ala Leu Arg Ile Pro Lys Asp Leu Ala Glu Asn Asn Lys Gly Ala 
            180                 185                 190         


Arg Val Leu Ile Val Cys Cys Glu Ile Phe Ala Phe Arg Gly Pro His 
        195                 200                 205             


Glu Asp His Met Asp Ser Leu Ile Cys Gln Leu Leu Phe Gly Asp Gly 
    210                 215                 220                 


Ala Ala Ala Val Ile Val Gly Gly Asp Pro Asp Glu Thr Glu Asn Ser 
225                 230                 235                 240 


Leu Phe Glu Leu Glu Trp Ala Asn Ser Thr Ile Ile Pro Gln Ser Glu 
                245                 250                 255     


Glu Ala Ile Thr Leu Lys Met Arg Glu Glu Gly Leu Met Ile Gly Leu 
            260                 265                 270         


Ser Lys Glu Ile Pro Arg Leu Leu Gly Glu Gln Ile Glu Asp Ile Leu 
        275                 280                 285             


Val Glu Ala Phe Ala Pro Leu Gly Ile Ser Asp Trp Ser Ser Leu Phe 
    290                 295                 300                 


Trp Ile Ala His Pro Gly Gly Lys Ala Ile Leu Glu Ala Leu Glu Lys 
305                 310                 315                 320 


Lys Ile Gly Val Glu Gly Lys Leu Trp Ala Ser Trp His Val Leu Lys 
                325                 330                 335     


Glu Tyr Gly Asn Leu Thr Ser Ala Cys Val Leu Phe Ala Met Asp Glu 
            340                 345                 350         


Met Arg Lys Arg Ser Ile Lys Glu Gly Lys Ala Thr Thr Gly Asp Gly 
        355                 360                 365             


His Asp Tyr Gly Val Leu Phe Gly Val Gly Pro Gly Leu Thr Val Glu 
    370                 375                 380                 


Thr Val Val Leu Lys Ser Val Pro 
385                 390         


<210>  17
<211>  1176
<212>  DNA
<213>  Rheum palmatum


<220>
<221>  CDS
<222>  (1)..(1176)
<223>  ALS gene [GenBank ID number AY517486) encoding Type III 
       heptaketide synthase (GenBank ID number AAS87170)

<400>  17
atg gca gat gtc ctg cag gag atc cgc aac tcg cag aag gcg agc ggg         48
Met Ala Asp Val Leu Gln Glu Ile Arg Asn Ser Gln Lys Ala Ser Gly           
1               5                   10                  15                

ccc gcc acg gtg ctc gcc atc ggc act gcc cat cca ccg acg tgc tac         96
Pro Ala Thr Val Leu Ala Ile Gly Thr Ala His Pro Pro Thr Cys Tyr           
            20                  25                  30                    

cct cag gcc gac tac ccc gac ttc tac ttc cga gtt tgc aag agc gag        144
Pro Gln Ala Asp Tyr Pro Asp Phe Tyr Phe Arg Val Cys Lys Ser Glu           
        35                  40                  45                        

cac atg acc aaa ctc aag aag aaa atg caa ttc att tgt gac aga tcg        192
His Met Thr Lys Leu Lys Lys Lys Met Gln Phe Ile Cys Asp Arg Ser           
    50                  55                  60                            

ggg ata agg cag cgg ttt atg ttc cac acg gaa gag aac ctg ggg aag        240
Gly Ile Arg Gln Arg Phe Met Phe His Thr Glu Glu Asn Leu Gly Lys           
65                  70                  75                  80            

aac ccg ggg atg tgc aca ttc gac ggg cca tcg ctg aac gcg cgg cag        288
Asn Pro Gly Met Cys Thr Phe Asp Gly Pro Ser Leu Asn Ala Arg Gln           
                85                  90                  95                

gac atg ctg atc atg gaa gtg ccg aag ctg ggg gcg gag gcg gcg gag        336
Asp Met Leu Ile Met Glu Val Pro Lys Leu Gly Ala Glu Ala Ala Glu           
            100                 105                 110                   

aag gcg atc aag gag tgg ggg cag gac aag tcc cgg atc acc cac ctc        384
Lys Ala Ile Lys Glu Trp Gly Gln Asp Lys Ser Arg Ile Thr His Leu           
        115                 120                 125                       

atc ttc tgc acc acc acg agc aac gac atg ccc ggg gcg gac tac cag        432
Ile Phe Cys Thr Thr Thr Ser Asn Asp Met Pro Gly Ala Asp Tyr Gln           
    130                 135                 140                           

ttc gcc acc ctg ttc ggg ctg aac ccc ggc gtg agc cgc acc atg gtc        480
Phe Ala Thr Leu Phe Gly Leu Asn Pro Gly Val Ser Arg Thr Met Val           
145                 150                 155                 160           

tac cag cag ggc tgc ttc gcc ggg ggc acc gtg ctg cgc ctg gtc aag        528
Tyr Gln Gln Gly Cys Phe Ala Gly Gly Thr Val Leu Arg Leu Val Lys           
                165                 170                 175               

gac atc gcg gag aac aac aag ggg gcg cgc gtg ctg gtg gtg tgc tcg        576
Asp Ile Ala Glu Asn Asn Lys Gly Ala Arg Val Leu Val Val Cys Ser           
            180                 185                 190                   

gag atc gtg gcc ttc gcc ttc cgc ggg ccc cac gag gac cac atc gac        624
Glu Ile Val Ala Phe Ala Phe Arg Gly Pro His Glu Asp His Ile Asp           
        195                 200                 205                       

tcc ctc atc ggg cag ctc ctg ttc ggg gac ggg gcc gcc gcc ctc gtg        672
Ser Leu Ile Gly Gln Leu Leu Phe Gly Asp Gly Ala Ala Ala Leu Val           
    210                 215                 220                           

gtc ggg aca gac atc gac gag agc gtc gag agg ccc atc ttc cag atc        720
Val Gly Thr Asp Ile Asp Glu Ser Val Glu Arg Pro Ile Phe Gln Ile           
225                 230                 235                 240           

atg tcg gcg acc cag gcg acc atc ccc aac tcg ctg cac acc atg gct        768
Met Ser Ala Thr Gln Ala Thr Ile Pro Asn Ser Leu His Thr Met Ala           
                245                 250                 255               

ctc cat ctg acg gag gcg ggg ctg acc ttc cat ctc agc aag gag gtg        816
Leu His Leu Thr Glu Ala Gly Leu Thr Phe His Leu Ser Lys Glu Val           
            260                 265                 270                   

ccc aag gtg gtg agc gac aac atg gag gag ctc atg ctc gag gcc ttc        864
Pro Lys Val Val Ser Asp Asn Met Glu Glu Leu Met Leu Glu Ala Phe           
        275                 280                 285                       

aag ccg ctc ggg ata acc gat tgg aac tcc ata ttc tgg caa gtg cat        912
Lys Pro Leu Gly Ile Thr Asp Trp Asn Ser Ile Phe Trp Gln Val His           
    290                 295                 300                           

ccc ggg ggt aga gcc atc ctt gac aag atc gag gag aag ctg gag ctc        960
Pro Gly Gly Arg Ala Ile Leu Asp Lys Ile Glu Glu Lys Leu Glu Leu           
305                 310                 315                 320           

acc aag gat aag atg cgg gat tcc cgc tac atc ttg agc gag tac ggg       1008
Thr Lys Asp Lys Met Arg Asp Ser Arg Tyr Ile Leu Ser Glu Tyr Gly           
                325                 330                 335               

aat ctc acc agc gcc tgt gtg ctc ttt gtc atg gac gag atg agg aag       1056
Asn Leu Thr Ser Ala Cys Val Leu Phe Val Met Asp Glu Met Arg Lys           
            340                 345                 350                   

agg tcc ttc cgg gaa ggg aag cag acc acc gga gac ggc tac gag tgg       1104
Arg Ser Phe Arg Glu Gly Lys Gln Thr Thr Gly Asp Gly Tyr Glu Trp           
        355                 360                 365                       

ggt gtc gcc atc gga ttg ggg ccc ggt ctt acc gtc gag acc gtt gtc       1152
Gly Val Ala Ile Gly Leu Gly Pro Gly Leu Thr Val Glu Thr Val Val           
    370                 375                 380                           

ttg cgt agc gtc ccc att ccc tga                                       1176
Leu Arg Ser Val Pro Ile Pro                                               
385                 390                                                   


<210>  18
<211>  391
<212>  PRT
<213>  Rheum palmatum

<400>  18

Met Ala Asp Val Leu Gln Glu Ile Arg Asn Ser Gln Lys Ala Ser Gly 
1               5                   10                  15      


Pro Ala Thr Val Leu Ala Ile Gly Thr Ala His Pro Pro Thr Cys Tyr 
            20                  25                  30          


Pro Gln Ala Asp Tyr Pro Asp Phe Tyr Phe Arg Val Cys Lys Ser Glu 
        35                  40                  45              


His Met Thr Lys Leu Lys Lys Lys Met Gln Phe Ile Cys Asp Arg Ser 
    50                  55                  60                  


Gly Ile Arg Gln Arg Phe Met Phe His Thr Glu Glu Asn Leu Gly Lys 
65                  70                  75                  80  


Asn Pro Gly Met Cys Thr Phe Asp Gly Pro Ser Leu Asn Ala Arg Gln 
                85                  90                  95      


Asp Met Leu Ile Met Glu Val Pro Lys Leu Gly Ala Glu Ala Ala Glu 
            100                 105                 110         


Lys Ala Ile Lys Glu Trp Gly Gln Asp Lys Ser Arg Ile Thr His Leu 
        115                 120                 125             


Ile Phe Cys Thr Thr Thr Ser Asn Asp Met Pro Gly Ala Asp Tyr Gln 
    130                 135                 140                 


Phe Ala Thr Leu Phe Gly Leu Asn Pro Gly Val Ser Arg Thr Met Val 
145                 150                 155                 160 


Tyr Gln Gln Gly Cys Phe Ala Gly Gly Thr Val Leu Arg Leu Val Lys 
                165                 170                 175     


Asp Ile Ala Glu Asn Asn Lys Gly Ala Arg Val Leu Val Val Cys Ser 
            180                 185                 190         


Glu Ile Val Ala Phe Ala Phe Arg Gly Pro His Glu Asp His Ile Asp 
        195                 200                 205             


Ser Leu Ile Gly Gln Leu Leu Phe Gly Asp Gly Ala Ala Ala Leu Val 
    210                 215                 220                 


Val Gly Thr Asp Ile Asp Glu Ser Val Glu Arg Pro Ile Phe Gln Ile 
225                 230                 235                 240 


Met Ser Ala Thr Gln Ala Thr Ile Pro Asn Ser Leu His Thr Met Ala 
                245                 250                 255     


Leu His Leu Thr Glu Ala Gly Leu Thr Phe His Leu Ser Lys Glu Val 
            260                 265                 270         


Pro Lys Val Val Ser Asp Asn Met Glu Glu Leu Met Leu Glu Ala Phe 
        275                 280                 285             


Lys Pro Leu Gly Ile Thr Asp Trp Asn Ser Ile Phe Trp Gln Val His 
    290                 295                 300                 


Pro Gly Gly Arg Ala Ile Leu Asp Lys Ile Glu Glu Lys Leu Glu Leu 
305                 310                 315                 320 


Thr Lys Asp Lys Met Arg Asp Ser Arg Tyr Ile Leu Ser Glu Tyr Gly 
                325                 330                 335     


Asn Leu Thr Ser Ala Cys Val Leu Phe Val Met Asp Glu Met Arg Lys 
            340                 345                 350         


Arg Ser Phe Arg Glu Gly Lys Gln Thr Thr Gly Asp Gly Tyr Glu Trp 
        355                 360                 365             


Gly Val Ala Ile Gly Leu Gly Pro Gly Leu Thr Val Glu Thr Val Val 
    370                 375                 380                 


Leu Arg Ser Val Pro Ile Pro 
385                 390     


<210>  19
<211>  1212
<212>  DNA
<213>  Aloe arborescens


<220>
<221>  CDS
<222>  (1)..(1212)
<223>  AaPKS3 gene [GenBank ID number EF537574) encoding a Type III  
       heptaketide synthase (GenBank ID number ABS72373)

<400>  19
atg ggt tca ctc tcc gac tct acg cct ttg atg aag gat gtg cag ggc         48
Met Gly Ser Leu Ser Asp Ser Thr Pro Leu Met Lys Asp Val Gln Gly           
1               5                   10                  15                

atc cga aag gcc caa aag gcc gac gga act gcg acc gtg atg gcc att         96
Ile Arg Lys Ala Gln Lys Ala Asp Gly Thr Ala Thr Val Met Ala Ile           
            20                  25                  30                    

gga aca gct cac cct cct cat atc att tcg cag gac agc tac gcg gat        144
Gly Thr Ala His Pro Pro His Ile Ile Ser Gln Asp Ser Tyr Ala Asp           
        35                  40                  45                        

ttc tac ttc cgg gtc acc aac agc gag cac aag gtc gag ctc aag aag        192
Phe Tyr Phe Arg Val Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys           
    50                  55                  60                            

aag ttc gat cgc atc tgc aag aaa acg atg ata ggc aag cgt tac ttt        240
Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe           
65                  70                  75                  80            

aac ttc gac gag gag ttc ttg aag aag tat ccc aac att act tca ttt        288
Asn Phe Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe           
                85                  90                  95                

gac aag ccc agc ctc aac gac agg cat gac att tgc att cct ggg gtg        336
Asp Lys Pro Ser Leu Asn Asp Arg His Asp Ile Cys Ile Pro Gly Val           
            100                 105                 110                   

ccg gcg ctg ggg gcg gaa gcg gct gtt aaa gcc att gag gag tgg gga        384
Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Glu Glu Trp Gly           
        115                 120                 125                       

cgc cct aag tct gag atc act cac ctc gtc ttc tgc acc agc ggc ggt        432
Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Gly Gly           
    130                 135                 140                           

gtt gac atg cct agt gcc gat ttc cag tgc gct aag ctc ctt ggc ctc        480
Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu           
145                 150                 155                 160           

cgc acc aat gtc aac aaa tac tgc atc tac atg cag gga tgc tat gct        528
Arg Thr Asn Val Asn Lys Tyr Cys Ile Tyr Met Gln Gly Cys Tyr Ala           
                165                 170                 175               

ggt ggc acc gtc atg cgg tat gcc aag gat ctg gcc gag aac aac cgt        576
Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg           
            180                 185                 190                   

ggt gct cgt gtt ctg atg gtg tgc gca gag ctc acc atc att gcg ctc        624
Gly Ala Arg Val Leu Met Val Cys Ala Glu Leu Thr Ile Ile Ala Leu           
        195                 200                 205                       

cgt ggc ccc aat gat tcc cat atc gac aat gct atc ggc aac tct ctt        672
Arg Gly Pro Asn Asp Ser His Ile Asp Asn Ala Ile Gly Asn Ser Leu           
    210                 215                 220                           

ttc gga gat gga gct gct gcg ctg att gtt ggg tca gac ccc atc atc        720
Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile           
225                 230                 235                 240           

ggt gtc gag aag ccc atg ttc gag att gtc tgc gca aag cag act gtg        768
Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val           
                245                 250                 255               

atc cca aac agt gaa gaa gtt atc cat ctc cac ctg agg gag tcg ggt        816
Ile Pro Asn Ser Glu Glu Val Ile His Leu His Leu Arg Glu Ser Gly           
            260                 265                 270                   

ctg atg ttc tac atg acc aag gac agc gcc gcg acc atc tcc aat aat        864
Leu Met Phe Tyr Met Thr Lys Asp Ser Ala Ala Thr Ile Ser Asn Asn           
        275                 280                 285                       

ata gag gcc tgc ctt gtt gat gtg ttt aag tcg gtg ggg atg act cct        912
Ile Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro           
    290                 295                 300                           

ccg gag gat tgg aac tct ctc ttc tgg atc cct cat ccc ggt ggc cgg        960
Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg           
305                 310                 315                 320           

gct atc ctc gac caa gtt gag gcc aag ctg aag ctt cgc ccc gag aag       1008
Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys           
                325                 330                 335               

ttt agt gcg act cga aca gtt ctc tgg gat tat ggc aac atg ata agt       1056
Phe Ser Ala Thr Arg Thr Val Leu Trp Asp Tyr Gly Asn Met Ile Ser           
            340                 345                 350                   

gca tgt gtg ctc tat ata ctg gat gag atg aga aga aaa tct gct gct       1104
Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Ala           
        355                 360                 365                       

gaa gga tta gaa acc tac gga gag ggg tta gag tgg ggt gtc ttg ctt       1152
Glu Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu           
    370                 375                 380                           

ggt ttt gga cca gga atg act att gaa act atc ctt ctt cat agc ctg       1200
Gly Phe Gly Pro Gly Met Thr Ile Glu Thr Ile Leu Leu His Ser Leu           
385                 390                 395                 400           

cct cct gtg taa                                                       1212
Pro Pro Val                                                               
                                                                          


<210>  20
<211>  403
<212>  PRT
<213>  Aloe arborescens

<400>  20

Met Gly Ser Leu Ser Asp Ser Thr Pro Leu Met Lys Asp Val Gln Gly 
1               5                   10                  15      


Ile Arg Lys Ala Gln Lys Ala Asp Gly Thr Ala Thr Val Met Ala Ile 
            20                  25                  30          


Gly Thr Ala His Pro Pro His Ile Ile Ser Gln Asp Ser Tyr Ala Asp 
        35                  40                  45              


Phe Tyr Phe Arg Val Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys 
    50                  55                  60                  


Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe 
65                  70                  75                  80  


Asn Phe Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe 
                85                  90                  95      


Asp Lys Pro Ser Leu Asn Asp Arg His Asp Ile Cys Ile Pro Gly Val 
            100                 105                 110         


Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Glu Glu Trp Gly 
        115                 120                 125             


Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Gly Gly 
    130                 135                 140                 


Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu 
145                 150                 155                 160 


Arg Thr Asn Val Asn Lys Tyr Cys Ile Tyr Met Gln Gly Cys Tyr Ala 
                165                 170                 175     


Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg 
            180                 185                 190         


Gly Ala Arg Val Leu Met Val Cys Ala Glu Leu Thr Ile Ile Ala Leu 
        195                 200                 205             


Arg Gly Pro Asn Asp Ser His Ile Asp Asn Ala Ile Gly Asn Ser Leu 
    210                 215                 220                 


Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile 
225                 230                 235                 240 


Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val 
                245                 250                 255     


Ile Pro Asn Ser Glu Glu Val Ile His Leu His Leu Arg Glu Ser Gly 
            260                 265                 270         


Leu Met Phe Tyr Met Thr Lys Asp Ser Ala Ala Thr Ile Ser Asn Asn 
        275                 280                 285             


Ile Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro 
    290                 295                 300                 


Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg 
305                 310                 315                 320 


Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys 
                325                 330                 335     


Phe Ser Ala Thr Arg Thr Val Leu Trp Asp Tyr Gly Asn Met Ile Ser 
            340                 345                 350         


Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Ala 
        355                 360                 365             


Glu Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu 
    370                 375                 380                 


Gly Phe Gly Pro Gly Met Thr Ile Glu Thr Ile Leu Leu His Ser Leu 
385                 390                 395                 400 


Pro Pro Val 
            


<210>  21
<211>  1212
<212>  DNA
<213>  Aloe arborescens


<220>
<221>  CDS
<222>  (1)..(1212)
<223>  OKS gene [GenBank ID number AY567707) encoding a Type III 
       octaketide (GenBank ID number AAT48709.1)

<400>  21
atg agt tca ctc tcc aac gct tcc cat ctg atg gag gat gtg cag ggc         48
Met Ser Ser Leu Ser Asn Ala Ser His Leu Met Glu Asp Val Gln Gly           
1               5                   10                  15                

atc cgg aag gcc cag aga gcc gat ggc acg gcc acc gtc atg gcc atc         96
Ile Arg Lys Ala Gln Arg Ala Asp Gly Thr Ala Thr Val Met Ala Ile           
            20                  25                  30                    

gga aca gct cac cct cct cat atc ttt cct cag gac acc tac gct gac        144
Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp           
        35                  40                  45                        

ttc tac ttc cgc gcc acc aac agc gag cac aag gtc gag ctc aag aag        192
Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys           
    50                  55                  60                            

aag ttc gat cgc atc tgc aaa aag aca atg ata ggc aag cgc tac ttc        240
Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe           
65                  70                  75                  80            

aac tac gac gag gag ttc ttg aag aaa tat ccc aat atc act tca ttc        288
Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe           
                85                  90                  95                

gat gag ccc agc ctc aac gac cgc cag gac att tgt gtc cct ggg gtg        336
Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val           
            100                 105                 110                   

cca gcc ctg gga gcc gaa gca gct gtg aaa gcc atc gcg gaa tgg gga        384
Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Ala Glu Trp Gly           
        115                 120                 125                       

cgc ccc aag tct gag att act cat ctc gtg ttc tgc acc tcc tgc ggt        432
Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly           
    130                 135                 140                           

gtc gac atg ccc agc gcc gac ttc cag tgc gcc aag ctc ctt ggc ctc        480
Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu           
145                 150                 155                 160           

cgc acc aat gtc aac aag tac tgc gtc tac atg caa gga tgc tat gct        528
Arg Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys Tyr Ala           
                165                 170                 175               

ggt ggc acc gtc atg cgg tat gcc aag gat ctg gcc gag aac aac cgt        576
Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg           
            180                 185                 190                   

ggt gct cgt gtt ttg gtg gtg tgt gcg gag ctc acc ata atc ggg ctt        624
Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile Gly Leu           
        195                 200                 205                       

cga ggc cct aat gag tcc cat ctc gac aac gcc atc gga aat tct ctt        672
Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Asn Ser Leu           
    210                 215                 220                           

ttc gga gat gga gct gcc gcg ttg atc gtc ggg tcg gac ccc atc atc        720
Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile           
225                 230                 235                 240           

ggt gtc gag aag ccc atg ttc gag atc gtg tgt gcc aag caa act gtg        768
Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val           
                245                 250                 255               

atc cca aac agc gaa gac gtt atc cat ctc cac atg aga gag gca ggt        816
Ile Pro Asn Ser Glu Asp Val Ile His Leu His Met Arg Glu Ala Gly           
            260                 265                 270                   

ctg atg ttc tac atg agc aag gac agt ccc gag acc atc tcc aat aac        864
Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser Asn Asn           
        275                 280                 285                       

gta gag gct tgc ctc gtt gat gtg ttc aag tct gtg ggg atg act cct        912
Val Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro           
    290                 295                 300                           

ccc gag gac tgg aac tct ctc ttc tgg atc cct cac ccc ggt ggt cgc        960
Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg           
305                 310                 315                 320           

gcc atc ctt gat caa gtt gag gcc aag ctg aag ctt cgt cct gag aag       1008
Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys           
                325                 330                 335               

ttc cgt gcg act cga acc gtg ctc tgg gat tgc ggt aac atg gtc agt       1056
Phe Arg Ala Thr Arg Thr Val Leu Trp Asp Cys Gly Asn Met Val Ser           
            340                 345                 350                   

gcg tgt gtg ctc tac ata ttg gat gag atg aga aga aaa tcc gct gat       1104
Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Asp           
        355                 360                 365                       

gaa gga cta gag acc tac gga gag gga cta gag tgg ggt gtc ttg ctt       1152
Glu Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu           
    370                 375                 380                           

gga ttt gga cca ggg atg acc gtt gaa act atc ctt ctc cac agc ctg       1200
Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His Ser Leu           
385                 390                 395                 400           

cct ctc atg tga                                                       1212
Pro Leu Met                                                               
                                                                          


<210>  22
<211>  403
<212>  PRT
<213>  Aloe arborescens

<400>  22

Met Ser Ser Leu Ser Asn Ala Ser His Leu Met Glu Asp Val Gln Gly 
1               5                   10                  15      


Ile Arg Lys Ala Gln Arg Ala Asp Gly Thr Ala Thr Val Met Ala Ile 
            20                  25                  30          


Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp 
        35                  40                  45              


Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys 
    50                  55                  60                  


Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe 
65                  70                  75                  80  


Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe 
                85                  90                  95      


Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val 
            100                 105                 110         


Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Ala Glu Trp Gly 
        115                 120                 125             


Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly 
    130                 135                 140                 


Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu 
145                 150                 155                 160 


Arg Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys Tyr Ala 
                165                 170                 175     


Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg 
            180                 185                 190         


Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile Gly Leu 
        195                 200                 205             


Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Asn Ser Leu 
    210                 215                 220                 


Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile 
225                 230                 235                 240 


Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val 
                245                 250                 255     


Ile Pro Asn Ser Glu Asp Val Ile His Leu His Met Arg Glu Ala Gly 
            260                 265                 270         


Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser Asn Asn 
        275                 280                 285             


Val Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro 
    290                 295                 300                 


Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg 
305                 310                 315                 320 


Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys 
                325                 330                 335     


Phe Arg Ala Thr Arg Thr Val Leu Trp Asp Cys Gly Asn Met Val Ser 
            340                 345                 350         


Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Asp 
        355                 360                 365             


Glu Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu 
    370                 375                 380                 


Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His Ser Leu 
385                 390                 395                 400 


Pro Leu Met 
            


<210>  23
<211>  1212
<212>  DNA
<213>  Aloe arborescens


<220>
<221>  CDS
<222>  (1)..(1212)
<223>  OKS2 gene [GenBank ID number FJ536166) encoding a Type III 
       octaketide synthase (GenBank ID number ACR19997.1)

<400>  23
atg ggt tca ctc tcc aac tac tcg cca gtg atg gag gat gtg cag gcc         48
Met Gly Ser Leu Ser Asn Tyr Ser Pro Val Met Glu Asp Val Gln Ala           
1               5                   10                  15                

atc cga aag gcc caa aaa gca gat gga acc gca aca gtg atg gcc atc         96
Ile Arg Lys Ala Gln Lys Ala Asp Gly Thr Ala Thr Val Met Ala Ile           
            20                  25                  30                    

gga aca gct cac cct cct cat atc ttt cct cag gac acc tac gcc gac        144
Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp           
        35                  40                  45                        

ttc tac ttc cgc gcc acc aac agc gag cac aaa gtc gag ctc aag aag        192
Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys           
    50                  55                  60                            

aaa ttc gat cgt atc tgc aaa aag aca atg ata ggc aag cgc tac ttc        240
Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe           
65                  70                  75                  80            

aat tac gat gag gag ttc ctc aag aag tat ccc aac att acc tca ttc        288
Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe           
                85                  90                  95                

gac gag ccc agc ctc aac gac cgc cag gat att tgc gtc cct ggg gtg        336
Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val           
            100                 105                 110                   

ccg gcc ctg gga gcc gaa gca gct gtc aaa gcc atc gct gaa tgg gga        384
Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Ala Glu Trp Gly           
        115                 120                 125                       

cgt cca aag tct gag atc act cat ctc gtc ttc tgc acc tcc tgc ggt        432
Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly           
    130                 135                 140                           

gtc gac atg cct agc gcc gac ttc cag tgc gcc aag ctc ctc ggc ctc        480
Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu           
145                 150                 155                 160           

cgc acc aat gtc aac aag tat tgc gtc tac atg cag gga tgc tat gct        528
Arg Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys Tyr Ala           
                165                 170                 175               

ggc ggc aca gtc atg cgg tac gcc aag gat ctc gcc gag aac aac cgt        576
Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg           
            180                 185                 190                   

ggt gct cgt gtt cta gtg gtg tgc gcc gag ctc acc atc atc ggg ctt        624
Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile Gly Leu           
        195                 200                 205                       

cgc gga cca aat gag tcc cat ctc gac aac gcc atc ggc aac tcc ctt        672
Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Asn Ser Leu           
    210                 215                 220                           

ttc gga gac gga gct gct gcg ctg atc gtc ggg tca gac ccc atc att        720
Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile           
225                 230                 235                 240           

ggt gtc gag agg cct atg ttc gag atc gtg tgc gca aag cag acc gtg        768
Gly Val Glu Arg Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val           
                245                 250                 255               

atc cca aac agt gaa gat gtt atc cat ctc cac atg agg gag gcg ggt        816
Ile Pro Asn Ser Glu Asp Val Ile His Leu His Met Arg Glu Ala Gly           
            260                 265                 270                   

cta atg ttc tac atg agc aag gac agc ccc gag acc atc tcc aac aat        864
Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser Asn Asn           
        275                 280                 285                       

gta gag gca tgc ctt gtc gat gtg ttc aag tcg gtg ggg atg act cct        912
Val Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro           
    290                 295                 300                           

ccc gag gac tgg aac tct ctc ttc tgg atc cct cac ccc ggc ggt cga        960
Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg           
305                 310                 315                 320           

gct atc ctc gac cag gtt gag gcc agg ctt aag ctt cgt ccc gag aag       1008
Ala Ile Leu Asp Gln Val Glu Ala Arg Leu Lys Leu Arg Pro Glu Lys           
                325                 330                 335               

ttc ggc gcg act cga act gtg ctc tgg gat tgc gga aac atg gtg agc       1056
Phe Gly Ala Thr Arg Thr Val Leu Trp Asp Cys Gly Asn Met Val Ser           
            340                 345                 350                   

gcg tgt gtt ctc tac att ttg gat gag atg aga aga aaa tct gtt gcc       1104
Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Val Ala           
        355                 360                 365                       

gac gga cta gca acc tac gga gag ggg ctg gag tgg ggt gtc ttg ctt       1152
Asp Gly Leu Ala Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu           
    370                 375                 380                           

ggt ttc gga cca ggg atg acc gtt gaa act atc ctt ctc cac agc ctg       1200
Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His Ser Leu           
385                 390                 395                 400           

ccc cct gtg taa                                                       1212
Pro Pro Val                                                               
                                                                          


<210>  24
<211>  403
<212>  PRT
<213>  Aloe arborescens

<400>  24

Met Gly Ser Leu Ser Asn Tyr Ser Pro Val Met Glu Asp Val Gln Ala 
1               5                   10                  15      


Ile Arg Lys Ala Gln Lys Ala Asp Gly Thr Ala Thr Val Met Ala Ile 
            20                  25                  30          


Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp 
        35                  40                  45              


Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys 
    50                  55                  60                  


Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe 
65                  70                  75                  80  


Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe 
                85                  90                  95      


Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val 
            100                 105                 110         


Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Ala Glu Trp Gly 
        115                 120                 125             


Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly 
    130                 135                 140                 


Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu 
145                 150                 155                 160 


Arg Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys Tyr Ala 
                165                 170                 175     


Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg 
            180                 185                 190         


Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile Gly Leu 
        195                 200                 205             


Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Asn Ser Leu 
    210                 215                 220                 


Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile 
225                 230                 235                 240 


Gly Val Glu Arg Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val 
                245                 250                 255     


Ile Pro Asn Ser Glu Asp Val Ile His Leu His Met Arg Glu Ala Gly 
            260                 265                 270         


Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser Asn Asn 
        275                 280                 285             


Val Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro 
    290                 295                 300                 


Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg 
305                 310                 315                 320 


Ala Ile Leu Asp Gln Val Glu Ala Arg Leu Lys Leu Arg Pro Glu Lys 
                325                 330                 335     


Phe Gly Ala Thr Arg Thr Val Leu Trp Asp Cys Gly Asn Met Val Ser 
            340                 345                 350         


Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Val Ala 
        355                 360                 365             


Asp Gly Leu Ala Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu 
    370                 375                 380                 


Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His Ser Leu 
385                 390                 395                 400 


Pro Pro Val 
            


<210>  25
<211>  1218
<212>  DNA
<213>  Aloe arborescens


<220>
<221>  CDS
<222>  (1)..(1218)
<223>  OKS3 gene [GenBank ID number FJ536167) encoding a Type III 
       octaketide synthase (GenBank ID number ACR19998.1)

<400>  25
atg ggt tcg atc gcc gag tct tca cca ctg atg agt agg gag aat gtg         48
Met Gly Ser Ile Ala Glu Ser Ser Pro Leu Met Ser Arg Glu Asn Val           
1               5                   10                  15                

gag ggc atc aga aaa gcg cag aga gct gag gga acc gca act gtg atg         96
Glu Gly Ile Arg Lys Ala Gln Arg Ala Glu Gly Thr Ala Thr Val Met           
            20                  25                  30                    

gcc atc gga act gct cac cct ccc cat atc ttt cct cag gac acc tac        144
Ala Ile Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr           
        35                  40                  45                        

gca gac ttc tac ttc cgc gcc acc aac agc gag cac aaa gtt gag ctc        192
Ala Asp Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu           
    50                  55                  60                            

aag aag aag ttc gac cga atc tgc aaa aag aca atg att ggc aaa cgc        240
Lys Lys Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg           
65                  70                  75                  80            

tac ttc aac tac gac gag gag ttc ctc aag aag tac cca aac atc aca        288
Tyr Phe Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr           
                85                  90                  95                

tcc ttc gac gag ccc agc ctg aac gac cgc cag gac atc tgc gtc ccc        336
Ser Phe Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro           
            100                 105                 110                   

gga gtc ccc gcc ttg ggt aag gag gcc gct ctc aaa gcc atc gag gaa        384
Gly Val Pro Ala Leu Gly Lys Glu Ala Ala Leu Lys Ala Ile Glu Glu           
        115                 120                 125                       

tgg ggg caa cct ctg tcc aag atc acc cat ctc gtc ttc tgc acc tcc        432
Trp Gly Gln Pro Leu Ser Lys Ile Thr His Leu Val Phe Cys Thr Ser           
    130                 135                 140                           

tgc ggc gtc gac atg ccc agc gcc gat ttc cag ctc gcc aag ctc ctc        480
Cys Gly Val Asp Met Pro Ser Ala Asp Phe Gln Leu Ala Lys Leu Leu           
145                 150                 155                 160           

gga ctc aac acc aac gtc aac aag tac tgc gtc tac atg cag ggc tgc        528
Gly Leu Asn Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys           
                165                 170                 175               

tac gcc ggc ggc acc gtc ctc cgc tac gcc aag gac ctc gcc gag aac        576
Tyr Ala Gly Gly Thr Val Leu Arg Tyr Ala Lys Asp Leu Ala Glu Asn           
            180                 185                 190                   

aac cgc ggc tcc cgc gtc ctc gtc gtc tgc gcc gag ctc acc atc atc        624
Asn Arg Gly Ser Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile           
        195                 200                 205                       

ggc ctc cgc ggc cca aac gag tcc cac ctc gac aac gcc atc ggg aac        672
Gly Leu Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Asn           
    210                 215                 220                           

tcc ctc ttc ggc gac ggg gcc gcc gcg ctc atc gtg ggc gcc gat cct        720
Ser Leu Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ala Asp Pro           
225                 230                 235                 240           

att gtt ggc ata gag aag ccc atc ttc gag atc gtc tgc gca aag cag        768
Ile Val Gly Ile Glu Lys Pro Ile Phe Glu Ile Val Cys Ala Lys Gln           
                245                 250                 255               

acc gtc atc ccc gac agc gag gac gtc atc cac ctc cac ctc cgc gag        816
Thr Val Ile Pro Asp Ser Glu Asp Val Ile His Leu His Leu Arg Glu           
            260                 265                 270                   

gcc ggc ctc atg ttc tac atg agc aag gac agc ccc gag acc atc tcc        864
Ala Gly Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser           
        275                 280                 285                       

aac aac gtc gag ggc tgc ctc gtc gac atc ttc aag tcc gtc ggc atg        912
Asn Asn Val Glu Gly Cys Leu Val Asp Ile Phe Lys Ser Val Gly Met           
    290                 295                 300                           

acc ccg ccc gcc gac tgg aac tcc ctc ttc tgg atc ccc cac ccc ggc        960
Thr Pro Pro Ala Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly           
305                 310                 315                 320           

ggc cga gcc atc ctc gac gag gtc gag gcc agg ctc aag ctc cgc ccg       1008
Gly Arg Ala Ile Leu Asp Glu Val Glu Ala Arg Leu Lys Leu Arg Pro           
                325                 330                 335               

gag aag ttt aga gca acc agg cac gtg ctc tgg gag tac ggg aac atg       1056
Glu Lys Phe Arg Ala Thr Arg His Val Leu Trp Glu Tyr Gly Asn Met           
            340                 345                 350                   

gtc agc gca tgc gtt ctc tac ata ctg gac gag atg agg aac aag tcc       1104
Val Ser Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Asn Lys Ser           
        355                 360                 365                       

gca gcc gac gga ttg ggg acc tac gga gaa gga ctc gaa tgg ggc gtc       1152
Ala Ala Asp Gly Leu Gly Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val           
    370                 375                 380                           

ttg ctc ggt ttc gga ccc gga atg acc gtc gag acc atc ctc ctc cac       1200
Leu Leu Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His           
385                 390                 395                 400           

agc ctg cct cct gtc taa                                               1218
Ser Leu Pro Pro Val                                                       
                405                                                       


<210>  26
<211>  405
<212>  PRT
<213>  Aloe arborescens

<400>  26

Met Gly Ser Ile Ala Glu Ser Ser Pro Leu Met Ser Arg Glu Asn Val 
1               5                   10                  15      


Glu Gly Ile Arg Lys Ala Gln Arg Ala Glu Gly Thr Ala Thr Val Met 
            20                  25                  30          


Ala Ile Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr 
        35                  40                  45              


Ala Asp Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu 
    50                  55                  60                  


Lys Lys Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg 
65                  70                  75                  80  


Tyr Phe Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr 
                85                  90                  95      


Ser Phe Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro 
            100                 105                 110         


Gly Val Pro Ala Leu Gly Lys Glu Ala Ala Leu Lys Ala Ile Glu Glu 
        115                 120                 125             


Trp Gly Gln Pro Leu Ser Lys Ile Thr His Leu Val Phe Cys Thr Ser 
    130                 135                 140                 


Cys Gly Val Asp Met Pro Ser Ala Asp Phe Gln Leu Ala Lys Leu Leu 
145                 150                 155                 160 


Gly Leu Asn Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys 
                165                 170                 175     


Tyr Ala Gly Gly Thr Val Leu Arg Tyr Ala Lys Asp Leu Ala Glu Asn 
            180                 185                 190         


Asn Arg Gly Ser Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile 
        195                 200                 205             


Gly Leu Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Asn 
    210                 215                 220                 


Ser Leu Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ala Asp Pro 
225                 230                 235                 240 


Ile Val Gly Ile Glu Lys Pro Ile Phe Glu Ile Val Cys Ala Lys Gln 
                245                 250                 255     


Thr Val Ile Pro Asp Ser Glu Asp Val Ile His Leu His Leu Arg Glu 
            260                 265                 270         


Ala Gly Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser 
        275                 280                 285             


Asn Asn Val Glu Gly Cys Leu Val Asp Ile Phe Lys Ser Val Gly Met 
    290                 295                 300                 


Thr Pro Pro Ala Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly 
305                 310                 315                 320 


Gly Arg Ala Ile Leu Asp Glu Val Glu Ala Arg Leu Lys Leu Arg Pro 
                325                 330                 335     


Glu Lys Phe Arg Ala Thr Arg His Val Leu Trp Glu Tyr Gly Asn Met 
            340                 345                 350         


Val Ser Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Asn Lys Ser 
        355                 360                 365             


Ala Ala Asp Gly Leu Gly Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val 
    370                 375                 380                 


Leu Leu Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His 
385                 390                 395                 400 


Ser Leu Pro Pro Val 
                405 


<210>  27
<211>  1182
<212>  DNA
<213>  Hypericum perforatum


<220>
<221>  CDS
<222>  (1)..(1182)
<223>  HpPKS2 gene [GenBank ID number HQ529467) encoding a Type III  
       octaketide synthase (GenBank ID number AEE69029)

<400>  27
atg ggt tcc ctt gac aat ggt tca gct aga att aac aac cag aaa tct         48
Met Gly Ser Leu Asp Asn Gly Ser Ala Arg Ile Asn Asn Gln Lys Ser           
1               5                   10                  15                

aat ggg ttg gct tca att ttg gcc att gga act gca ctt ccg ccg att         96
Asn Gly Leu Ala Ser Ile Leu Ala Ile Gly Thr Ala Leu Pro Pro Ile           
            20                  25                  30                    

tgc att aag caa gat gac tat cct gat tac tac ttc cga gtc acc aaa        144
Cys Ile Lys Gln Asp Asp Tyr Pro Asp Tyr Tyr Phe Arg Val Thr Lys           
        35                  40                  45                        

agc gac cac aag acg caa ctg aaa gag aag ttt cgt cgc atc tgt gaa        192
Ser Asp His Lys Thr Gln Leu Lys Glu Lys Phe Arg Arg Ile Cys Glu           
    50                  55                  60                            

aag tca gga gtg aca aaa cga tac aca gta cta acc gaa gac atg atc        240
Lys Ser Gly Val Thr Lys Arg Tyr Thr Val Leu Thr Glu Asp Met Ile           
65                  70                  75                  80            

aag gag aac gag aac ata ata acc tac aag gct ccg tca ctg gat gct        288
Lys Glu Asn Glu Asn Ile Ile Thr Tyr Lys Ala Pro Ser Leu Asp Ala           
                85                  90                  95                

cgc caa gcg atc cta cac aag gag aca ccc aag ctc gcc ata gaa gca        336
Arg Gln Ala Ile Leu His Lys Glu Thr Pro Lys Leu Ala Ile Glu Ala           
            100                 105                 110                   

gcc ttg aag acc atc caa gaa tgg ggc caa ccc gtc tct aag atc acc        384
Ala Leu Lys Thr Ile Gln Glu Trp Gly Gln Pro Val Ser Lys Ile Thr           
        115                 120                 125                       

cac ctg ttc ttt tgc tcc tcc tct ggc ggc tgc tat ctt ccg agc tcc        432
His Leu Phe Phe Cys Ser Ser Ser Gly Gly Cys Tyr Leu Pro Ser Ser           
    130                 135                 140                           

gat ttt cag atc gct aag gca ctc ggc ctc gag ccg acc gtc cag agg        480
Asp Phe Gln Ile Ala Lys Ala Leu Gly Leu Glu Pro Thr Val Gln Arg           
145                 150                 155                 160           

tcc atg gtg ttt cct cat gga tgc tat gct gcc agt tct ggc ctg cgt        528
Ser Met Val Phe Pro His Gly Cys Tyr Ala Ala Ser Ser Gly Leu Arg           
                165                 170                 175               

ttg gcc aag gac att gca gag aac aac aaa gat gca cgc gtg ctg gtg        576
Leu Ala Lys Asp Ile Ala Glu Asn Asn Lys Asp Ala Arg Val Leu Val           
            180                 185                 190                   

gtg tgc tgc gag ttg atg gtg tcg agc ttc cat gca cca tcg gag gac        624
Val Cys Cys Glu Leu Met Val Ser Ser Phe His Ala Pro Ser Glu Asp           
        195                 200                 205                       

gcg atc gga atg cta ata ggt cat gcc atc ttc ggc gat gga gcg gcc        672
Ala Ile Gly Met Leu Ile Gly His Ala Ile Phe Gly Asp Gly Ala Ala           
    210                 215                 220                           

tgc gca att gta gga gca gac ccg ggg cct acg gag cgc cca ata ttc        720
Cys Ala Ile Val Gly Ala Asp Pro Gly Pro Thr Glu Arg Pro Ile Phe           
225                 230                 235                 240           

gag cta gtg aag ggc gga cag gtg atc gtc cca gac acg gaa gac tgt        768
Glu Leu Val Lys Gly Gly Gln Val Ile Val Pro Asp Thr Glu Asp Cys           
                245                 250                 255               

ctg gga ggg tgg gtg atg gag atg gga tgg atc tac gat ctc aac aag        816
Leu Gly Gly Trp Val Met Glu Met Gly Trp Ile Tyr Asp Leu Asn Lys           
            260                 265                 270                   

cgc ctt cct caa gcc cta gcc gac aac atc ctc gga gcc cta gat gac        864
Arg Leu Pro Gln Ala Leu Ala Asp Asn Ile Leu Gly Ala Leu Asp Asp           
        275                 280                 285                       

acc ctg agg ctg aca ggt aaa agg gat gac ctc aat ggc ctt ttc tac        912
Thr Leu Arg Leu Thr Gly Lys Arg Asp Asp Leu Asn Gly Leu Phe Tyr           
    290                 295                 300                           

gtg ctc cac ccg ggt ggg cgg gcc atc atc gac ctg ctt gag gag aag        960
Val Leu His Pro Gly Gly Arg Ala Ile Ile Asp Leu Leu Glu Glu Lys           
305                 310                 315                 320           

ctt gag cta aca aag gac aag ctc gag agt agc cgt cgt gtg ctc agc       1008
Leu Glu Leu Thr Lys Asp Lys Leu Glu Ser Ser Arg Arg Val Leu Ser           
                325                 330                 335               

aac tat ggc aac atg tgg ggc cct gcg cta gtg ttc acg ctc gac gag       1056
Asn Tyr Gly Asn Met Trp Gly Pro Ala Leu Val Phe Thr Leu Asp Glu           
            340                 345                 350                   

atg agg agg aag tca aag gag gac aac gcc acc acc act ggt ggc ggg       1104
Met Arg Arg Lys Ser Lys Glu Asp Asn Ala Thr Thr Thr Gly Gly Gly           
        355                 360                 365                       

tcc gag ctc ggc ctg atg atg gcg ttt gga cct ggc ctc acc acc gag       1152
Ser Glu Leu Gly Leu Met Met Ala Phe Gly Pro Gly Leu Thr Thr Glu           
    370                 375                 380                           

atc atg gtt ctc cga agt gtg cct ctc taa                               1182
Ile Met Val Leu Arg Ser Val Pro Leu                                       
385                 390                                                   


<210>  28
<211>  393
<212>  PRT
<213>  Hypericum perforatum

<400>  28

Met Gly Ser Leu Asp Asn Gly Ser Ala Arg Ile Asn Asn Gln Lys Ser 
1               5                   10                  15      


Asn Gly Leu Ala Ser Ile Leu Ala Ile Gly Thr Ala Leu Pro Pro Ile 
            20                  25                  30          


Cys Ile Lys Gln Asp Asp Tyr Pro Asp Tyr Tyr Phe Arg Val Thr Lys 
        35                  40                  45              


Ser Asp His Lys Thr Gln Leu Lys Glu Lys Phe Arg Arg Ile Cys Glu 
    50                  55                  60                  


Lys Ser Gly Val Thr Lys Arg Tyr Thr Val Leu Thr Glu Asp Met Ile 
65                  70                  75                  80  


Lys Glu Asn Glu Asn Ile Ile Thr Tyr Lys Ala Pro Ser Leu Asp Ala 
                85                  90                  95      


Arg Gln Ala Ile Leu His Lys Glu Thr Pro Lys Leu Ala Ile Glu Ala 
            100                 105                 110         


Ala Leu Lys Thr Ile Gln Glu Trp Gly Gln Pro Val Ser Lys Ile Thr 
        115                 120                 125             


His Leu Phe Phe Cys Ser Ser Ser Gly Gly Cys Tyr Leu Pro Ser Ser 
    130                 135                 140                 


Asp Phe Gln Ile Ala Lys Ala Leu Gly Leu Glu Pro Thr Val Gln Arg 
145                 150                 155                 160 


Ser Met Val Phe Pro His Gly Cys Tyr Ala Ala Ser Ser Gly Leu Arg 
                165                 170                 175     


Leu Ala Lys Asp Ile Ala Glu Asn Asn Lys Asp Ala Arg Val Leu Val 
            180                 185                 190         


Val Cys Cys Glu Leu Met Val Ser Ser Phe His Ala Pro Ser Glu Asp 
        195                 200                 205             


Ala Ile Gly Met Leu Ile Gly His Ala Ile Phe Gly Asp Gly Ala Ala 
    210                 215                 220                 


Cys Ala Ile Val Gly Ala Asp Pro Gly Pro Thr Glu Arg Pro Ile Phe 
225                 230                 235                 240 


Glu Leu Val Lys Gly Gly Gln Val Ile Val Pro Asp Thr Glu Asp Cys 
                245                 250                 255     


Leu Gly Gly Trp Val Met Glu Met Gly Trp Ile Tyr Asp Leu Asn Lys 
            260                 265                 270         


Arg Leu Pro Gln Ala Leu Ala Asp Asn Ile Leu Gly Ala Leu Asp Asp 
        275                 280                 285             


Thr Leu Arg Leu Thr Gly Lys Arg Asp Asp Leu Asn Gly Leu Phe Tyr 
    290                 295                 300                 


Val Leu His Pro Gly Gly Arg Ala Ile Ile Asp Leu Leu Glu Glu Lys 
305                 310                 315                 320 


Leu Glu Leu Thr Lys Asp Lys Leu Glu Ser Ser Arg Arg Val Leu Ser 
                325                 330                 335     


Asn Tyr Gly Asn Met Trp Gly Pro Ala Leu Val Phe Thr Leu Asp Glu 
            340                 345                 350         


Met Arg Arg Lys Ser Lys Glu Asp Asn Ala Thr Thr Thr Gly Gly Gly 
        355                 360                 365             


Ser Glu Leu Gly Leu Met Met Ala Phe Gly Pro Gly Leu Thr Thr Glu 
    370                 375                 380                 


Ile Met Val Leu Arg Ser Val Pro Leu 
385                 390             


<210>  29
<211>  403
<212>  PRT
<213>  Aloe arborescens


<220>
<221>  PROPEP
<222>  (1)..(403)
<223>  PCS (F80A/Y82A/M207G) derived from GenBank ID number AAX35541.1 
       having nonaketide synthse activity

<400>  29

Met Ser Ser Leu Ser Asn Ser Leu Pro Leu Met Glu Asp Val Gln Gly 
1               5                   10                  15      


Ile Arg Lys Ala Gln Lys Ala Asp Gly Thr Ala Thr Val Met Ala Ile 
            20                  25                  30          


Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp 
        35                  40                  45              


Val Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys 
    50                  55                  60                  


Lys Phe Asp His Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Ala 
65                  70                  75                  80  


Asn Ala Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Tyr 
                85                  90                  95      


Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val 
            100                 105                 110         


Pro Ala Leu Gly Thr Glu Ala Ala Val Lys Ala Ile Glu Glu Trp Gly 
        115                 120                 125             


Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly 
    130                 135                 140                 


Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu 
145                 150                 155                 160 


His Ala Asn Val Asn Lys Tyr Cys Ile Tyr Met Gln Gly Cys Tyr Ala 
                165                 170                 175     


Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg 
            180                 185                 190         


Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Met Gly Leu 
        195                 200                 205             


Arg Ala Pro Asn Glu Thr His Leu Asp Asn Ala Ile Gly Ile Ser Leu 
    210                 215                 220                 


Phe Gly Asp Gly Ala Ala Ala Leu Ile Ile Gly Ser Asp Pro Ile Ile 
225                 230                 235                 240 


Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Thr Lys Gln Thr Val 
                245                 250                 255     


Ile Pro Asn Thr Glu Asp Val Ile His Leu His Leu Arg Glu Thr Gly 
            260                 265                 270         


Met Met Phe Tyr Leu Ser Lys Gly Ser Pro Met Thr Ile Ser Asn Asn 
        275                 280                 285             


Val Glu Ala Cys Leu Ile Asp Val Phe Lys Ser Val Gly Ile Thr Pro 
    290                 295                 300                 


Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg 
305                 310                 315                 320 


Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys 
                325                 330                 335     


Phe Arg Ala Ala Arg Thr Val Leu Trp Asp Tyr Gly Asn Met Val Ser 
            340                 345                 350         


Ala Ser Val Gly Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Ala 
        355                 360                 365             


Lys Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu 
    370                 375                 380                 


Gly Phe Gly Pro Gly Ile Thr Val Glu Thr Ile Leu Leu His Ser Leu 
385                 390                 395                 400 


Pro Leu Met 
            


<210>  30
<211>  403
<212>  PRT
<213>  Aloe arborescens


<220>
<221>  PROPEP
<222>  (1)..(403)
<223>  OKS N222G mutant polypeptide (derived from GenBank ID number 
       AAT48709.1) having decaketide synthase activity.

<400>  30

Met Ser Ser Leu Ser Asn Ala Ser His Leu Met Glu Asp Val Gln Gly 
1               5                   10                  15      


Ile Arg Lys Ala Gln Arg Ala Asp Gly Thr Ala Thr Val Met Ala Ile 
            20                  25                  30          


Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp 
        35                  40                  45              


Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys 
    50                  55                  60                  


Lys Phe Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe 
65                  70                  75                  80  


Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe 
                85                  90                  95      


Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val 
            100                 105                 110         


Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Ala Glu Trp Gly 
        115                 120                 125             


Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly 
    130                 135                 140                 


Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu 
145                 150                 155                 160 


Arg Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys Tyr Ala 
                165                 170                 175     


Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg 
            180                 185                 190         


Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile Gly Leu 
        195                 200                 205             


Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Gly Ser Leu 
    210                 215                 220                 


Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile 
225                 230                 235                 240 


Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val 
                245                 250                 255     


Ile Pro Asn Ser Glu Asp Val Ile His Leu His Met Arg Glu Ala Gly 
            260                 265                 270         


Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser Asn Asn 
        275                 280                 285             


Val Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro 
    290                 295                 300                 


Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg 
305                 310                 315                 320 


Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys 
                325                 330                 335     


Phe Arg Ala Thr Arg Thr Val Leu Trp Asp Cys Gly Asn Met Val Ser 
            340                 345                 350         


Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Asp 
        355                 360                 365             


Glu Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu 
    370                 375                 380                 


Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His Ser Leu 
385                 390                 395                 400 


Pro Leu Met 
            


<210>  31
<211>  403
<212>  PRT
<213>  Aloe arborescens


<220>
<221>  PROPEP
<222>  (1)..(403)
<223>  OKS mutant polypeptide  (F66L/N222G) derived from  GenBank ID 
       number AAT48709.1 having  dodecaketide synthase activity.

<400>  31

Met Ser Ser Leu Ser Asn Ala Ser His Leu Met Glu Asp Val Gln Gly 
1               5                   10                  15      


Ile Arg Lys Ala Gln Arg Ala Asp Gly Thr Ala Thr Val Met Ala Ile 
            20                  25                  30          


Gly Thr Ala His Pro Pro His Ile Phe Pro Gln Asp Thr Tyr Ala Asp 
        35                  40                  45              


Phe Tyr Phe Arg Ala Thr Asn Ser Glu His Lys Val Glu Leu Lys Lys 
    50                  55                  60                  


Lys Leu Asp Arg Ile Cys Lys Lys Thr Met Ile Gly Lys Arg Tyr Phe 
65                  70                  75                  80  


Asn Tyr Asp Glu Glu Phe Leu Lys Lys Tyr Pro Asn Ile Thr Ser Phe 
                85                  90                  95      


Asp Glu Pro Ser Leu Asn Asp Arg Gln Asp Ile Cys Val Pro Gly Val 
            100                 105                 110         


Pro Ala Leu Gly Ala Glu Ala Ala Val Lys Ala Ile Ala Glu Trp Gly 
        115                 120                 125             


Arg Pro Lys Ser Glu Ile Thr His Leu Val Phe Cys Thr Ser Cys Gly 
    130                 135                 140                 


Val Asp Met Pro Ser Ala Asp Phe Gln Cys Ala Lys Leu Leu Gly Leu 
145                 150                 155                 160 


Arg Thr Asn Val Asn Lys Tyr Cys Val Tyr Met Gln Gly Cys Tyr Ala 
                165                 170                 175     


Gly Gly Thr Val Met Arg Tyr Ala Lys Asp Leu Ala Glu Asn Asn Arg 
            180                 185                 190         


Gly Ala Arg Val Leu Val Val Cys Ala Glu Leu Thr Ile Ile Gly Leu 
        195                 200                 205             


Arg Gly Pro Asn Glu Ser His Leu Asp Asn Ala Ile Gly Gly Ser Leu 
    210                 215                 220                 


Phe Gly Asp Gly Ala Ala Ala Leu Ile Val Gly Ser Asp Pro Ile Ile 
225                 230                 235                 240 


Gly Val Glu Lys Pro Met Phe Glu Ile Val Cys Ala Lys Gln Thr Val 
                245                 250                 255     


Ile Pro Asn Ser Glu Asp Val Ile His Leu His Met Arg Glu Ala Gly 
            260                 265                 270         


Leu Met Phe Tyr Met Ser Lys Asp Ser Pro Glu Thr Ile Ser Asn Asn 
        275                 280                 285             


Val Glu Ala Cys Leu Val Asp Val Phe Lys Ser Val Gly Met Thr Pro 
    290                 295                 300                 


Pro Glu Asp Trp Asn Ser Leu Phe Trp Ile Pro His Pro Gly Gly Arg 
305                 310                 315                 320 


Ala Ile Leu Asp Gln Val Glu Ala Lys Leu Lys Leu Arg Pro Glu Lys 
                325                 330                 335     


Phe Arg Ala Thr Arg Thr Val Leu Trp Asp Cys Gly Asn Met Val Ser 
            340                 345                 350         


Ala Cys Val Leu Tyr Ile Leu Asp Glu Met Arg Arg Lys Ser Ala Asp 
        355                 360                 365             


Glu Gly Leu Glu Thr Tyr Gly Glu Gly Leu Glu Trp Gly Val Leu Leu 
    370                 375                 380                 


Gly Phe Gly Pro Gly Met Thr Val Glu Thr Ile Leu Leu His Ser Leu 
385                 390                 395                 400 


Pro Leu Met 
            


<210>  32
<211>  510
<212>  DNA
<213>  Streptomyces sp. R1128


<220>
<221>  CDS
<222>  (1)..(510)
<223>  ZhuI (type: SRPBCC) [GenBank ID number AF293442.1] encoding a  
       first 'small molecule foldase' [GenBank ID number AAG30197.1]

<400>  32
atg cgt cac gtc gaa cac acc gtc acc gta gcg gcc ccg gcc gac ctg         48
Met Arg His Val Glu His Thr Val Thr Val Ala Ala Pro Ala Asp Leu           
1               5                   10                  15                

gtc tgg gag gtg ctg gcc gat gtg ctc ggc tac gcc gac atc ttc ccg         96
Val Trp Glu Val Leu Ala Asp Val Leu Gly Tyr Ala Asp Ile Phe Pro           
            20                  25                  30                    

ccg acc gag aag gtc gag atc ctc gag gag ggt cag ggc tac cag gtc        144
Pro Thr Glu Lys Val Glu Ile Leu Glu Glu Gly Gln Gly Tyr Gln Val           
        35                  40                  45                        

gtc cgc ctg cac gtg gac gtc gcc ggc gag atc aac acc tgg acc tcg        192
Val Arg Leu His Val Asp Val Ala Gly Glu Ile Asn Thr Trp Thr Ser           
    50                  55                  60                            

cgc cgc gac ctg gac ccg gcc cgc cgc gtc atc gcc tac cgg cag ttg        240
Arg Arg Asp Leu Asp Pro Ala Arg Arg Val Ile Ala Tyr Arg Gln Leu           
65                  70                  75                  80            

gag acg gcc ccg atc gtc ggg cac atg agc ggc gag tgg cgc gcc ttc        288
Glu Thr Ala Pro Ile Val Gly His Met Ser Gly Glu Trp Arg Ala Phe           
                85                  90                  95                

acg ctg gac gcc gag cgc acc caa ctg gtg ctc acc cac gac ttc gtg        336
Thr Leu Asp Ala Glu Arg Thr Gln Leu Val Leu Thr His Asp Phe Val           
            100                 105                 110                   

acg cgc gcg gcc ggc gac gac ggc ctg gtg gcc ggc aag ctc acc ccc        384
Thr Arg Ala Ala Gly Asp Asp Gly Leu Val Ala Gly Lys Leu Thr Pro           
        115                 120                 125                       

gac gag gcg cgc gag atg ctg gag gcg gtc gtc gag cgc aac agc gtc        432
Asp Glu Ala Arg Glu Met Leu Glu Ala Val Val Glu Arg Asn Ser Val           
    130                 135                 140                           

gcc gac ctg aac gcg gtg ctc ggc gag gcc gag cgt cgg gtg cgc gcg        480
Ala Asp Leu Asn Ala Val Leu Gly Glu Ala Glu Arg Arg Val Arg Ala           
145                 150                 155                 160           

gcc ggc ggc gtc ggg acg gtg acc gcg tga                                510
Ala Gly Gly Val Gly Thr Val Thr Ala                                       
                165                                                       


<210>  33
<211>  169
<212>  PRT
<213>  Streptomyces sp. R1128

<400>  33

Met Arg His Val Glu His Thr Val Thr Val Ala Ala Pro Ala Asp Leu 
1               5                   10                  15      


Val Trp Glu Val Leu Ala Asp Val Leu Gly Tyr Ala Asp Ile Phe Pro 
            20                  25                  30          


Pro Thr Glu Lys Val Glu Ile Leu Glu Glu Gly Gln Gly Tyr Gln Val 
        35                  40                  45              


Val Arg Leu His Val Asp Val Ala Gly Glu Ile Asn Thr Trp Thr Ser 
    50                  55                  60                  


Arg Arg Asp Leu Asp Pro Ala Arg Arg Val Ile Ala Tyr Arg Gln Leu 
65                  70                  75                  80  


Glu Thr Ala Pro Ile Val Gly His Met Ser Gly Glu Trp Arg Ala Phe 
                85                  90                  95      


Thr Leu Asp Ala Glu Arg Thr Gln Leu Val Leu Thr His Asp Phe Val 
            100                 105                 110         


Thr Arg Ala Ala Gly Asp Asp Gly Leu Val Ala Gly Lys Leu Thr Pro 
        115                 120                 125             


Asp Glu Ala Arg Glu Met Leu Glu Ala Val Val Glu Arg Asn Ser Val 
    130                 135                 140                 


Ala Asp Leu Asn Ala Val Leu Gly Glu Ala Glu Arg Arg Val Arg Ala 
145                 150                 155                 160 


Ala Gly Gly Val Gly Thr Val Thr Ala 
                165                 


<210>  34
<211>  462
<212>  DNA
<213>  Actinomadura hibisca


<220>
<221>  CDS
<222>  (1)..(462)
<223>  pdmD (type: SRPBCC) gene [GenBank ID number EF151801.1 Position 
       23865 to 24326 (nucleotide seq.) encoding a 'first small molecule
       foldase' [GenBank ID number ABM21750.1]

<400>  34
atg acg cag tgg cgc acc gac agc gtg atc gtg atc gac gcg ccg ctc         48
Met Thr Gln Trp Arg Thr Asp Ser Val Ile Val Ile Asp Ala Pro Leu           
1               5                   10                  15                

gac gtc gtc tgg gac atg acc aac gac gtc gcc tcc tgg ccg gag ctg         96
Asp Val Val Trp Asp Met Thr Asn Asp Val Ala Ser Trp Pro Glu Leu           
            20                  25                  30                    

ttc gac gag tac gcc tcg gcc gag atc ctg gag cgc gac ggc gac acc        144
Phe Asp Glu Tyr Ala Ser Ala Glu Ile Leu Glu Arg Asp Gly Asp Thr           
        35                  40                  45                        

gtc cgc ttc cgg ctg acg atg cac ccc gac gcc gac ggc aac gcc tgg        192
Val Arg Phe Arg Leu Thr Met His Pro Asp Ala Asp Gly Asn Ala Trp           
    50                  55                  60                            

tcg tgg gtg tcg gag cgc acg ccc gac cgc gcc gcg ctc acc gtc aac        240
Ser Trp Val Ser Glu Arg Thr Pro Asp Arg Ala Ala Leu Thr Val Asn           
65                  70                  75                  80            

gcg cac cgc gtg gag acc ggc tgg ttc gag cac atg aac ctg cgc tgg        288
Ala His Arg Val Glu Thr Gly Trp Phe Glu His Met Asn Leu Arg Trp           
                85                  90                  95                

gac tac cgc gag gtg ccc ggc ggc gtg gag atg cgc tgg cgg cag gac        336
Asp Tyr Arg Glu Val Pro Gly Gly Val Glu Met Arg Trp Arg Gln Asp           
            100                 105                 110                   

ttc gcg atg aag gag gcg tcg ccg gtg tcg ctg gcg gcg atg acc gag        384
Phe Ala Met Lys Glu Ala Ser Pro Val Ser Leu Ala Ala Met Thr Glu           
        115                 120                 125                       

cgc atc cag agc aac tcc ccc gtc cag atg aag ctg atc aag gac aag        432
Arg Ile Gln Ser Asn Ser Pro Val Gln Met Lys Leu Ile Lys Asp Lys           
    130                 135                 140                           

gtg gag cgg gcg gcc cgg ggc gcg cgg tga                                462
Val Glu Arg Ala Ala Arg Gly Ala Arg                                       
145                 150                                                   


<210>  35
<211>  153
<212>  PRT
<213>  Actinomadura hibisca

<400>  35

Met Thr Gln Trp Arg Thr Asp Ser Val Ile Val Ile Asp Ala Pro Leu 
1               5                   10                  15      


Asp Val Val Trp Asp Met Thr Asn Asp Val Ala Ser Trp Pro Glu Leu 
            20                  25                  30          


Phe Asp Glu Tyr Ala Ser Ala Glu Ile Leu Glu Arg Asp Gly Asp Thr 
        35                  40                  45              


Val Arg Phe Arg Leu Thr Met His Pro Asp Ala Asp Gly Asn Ala Trp 
    50                  55                  60                  


Ser Trp Val Ser Glu Arg Thr Pro Asp Arg Ala Ala Leu Thr Val Asn 
65                  70                  75                  80  


Ala His Arg Val Glu Thr Gly Trp Phe Glu His Met Asn Leu Arg Trp 
                85                  90                  95      


Asp Tyr Arg Glu Val Pro Gly Gly Val Glu Met Arg Trp Arg Gln Asp 
            100                 105                 110         


Phe Ala Met Lys Glu Ala Ser Pro Val Ser Leu Ala Ala Met Thr Glu 
        115                 120                 125             


Arg Ile Gln Ser Asn Ser Pro Val Gln Met Lys Leu Ile Lys Asp Lys 
    130                 135                 140                 


Val Glu Arg Ala Ala Arg Gly Ala Arg 
145                 150             


<210>  36
<211>  456
<212>  DNA
<213>  Streptomyces sp. SANK 61196


<220>
<221>  CDS
<222>  (1)..(456)
<223>  sanI (type: SRPBCC) gene [GenBank ID number GU937384.1 position 
       11996 to 12451] encoding a first "small molecule foldase" 
       [GenBank ID number ADG86318.1]

<400>  36
atg gcg ctg acc gac aac acg atc gtc atc gac gcg ccc atg gac ctg         48
Met Ala Leu Thr Asp Asn Thr Ile Val Ile Asp Ala Pro Met Asp Leu           
1               5                   10                  15                

gtg tgg gag atg acc aac gac gtc gaa tcc tgg ccg acg ctc ttc tcc         96
Val Trp Glu Met Thr Asn Asp Val Glu Ser Trp Pro Thr Leu Phe Ser           
            20                  25                  30                    

gag tac gcc gcg gcc gag atc ctc ggc cgc acc ggg gcc acc gtc cgc        144
Glu Tyr Ala Ala Ala Glu Ile Leu Gly Arg Thr Gly Ala Thr Val Arg           
        35                  40                  45                        

ttc cgg ctc acg ctg cac ccg gac gag aac ggc gcg gtc tgg agc tgg        192
Phe Arg Leu Thr Leu His Pro Asp Glu Asn Gly Ala Val Trp Ser Trp           
    50                  55                  60                            

gtg tcg gag cgt act ccg gac ccg gag acc agg acg gta cgg gcg cgg        240
Val Ser Glu Arg Thr Pro Asp Pro Glu Thr Arg Thr Val Arg Ala Arg           
65                  70                  75                  80            

cgc atc gag acg ggc ccg ttc gag cac atg gac atc cac tgg aca tac        288
Arg Ile Glu Thr Gly Pro Phe Glu His Met Asp Ile His Trp Thr Tyr           
                85                  90                  95                

gcc gac acc gac ggc ggg gtg gag atg cgc tgg cgg cag gag ttc acg        336
Ala Asp Thr Asp Gly Gly Val Glu Met Arg Trp Arg Gln Glu Phe Thr           
            100                 105                 110                   

gtc cgt ccg ggc ctg ccg ttc ggc gac acg gag atg acc gag cgg ctg        384
Val Arg Pro Gly Leu Pro Phe Gly Asp Thr Glu Met Thr Glu Arg Leu           
        115                 120                 125                       

aac acc aac acc cgc cgg gaa atg gcc cgg atc aag ggc ctg gtg gag        432
Asn Thr Asn Thr Arg Arg Glu Met Ala Arg Ile Lys Gly Leu Val Glu           
    130                 135                 140                           

cgg gcc gcg gcg gtg gcg cgg tga                                        456
Arg Ala Ala Ala Val Ala Arg                                               
145                 150                                                   


<210>  37
<211>  151
<212>  PRT
<213>  Streptomyces sp. SANK 61196

<400>  37

Met Ala Leu Thr Asp Asn Thr Ile Val Ile Asp Ala Pro Met Asp Leu 
1               5                   10                  15      


Val Trp Glu Met Thr Asn Asp Val Glu Ser Trp Pro Thr Leu Phe Ser 
            20                  25                  30          


Glu Tyr Ala Ala Ala Glu Ile Leu Gly Arg Thr Gly Ala Thr Val Arg 
        35                  40                  45              


Phe Arg Leu Thr Leu His Pro Asp Glu Asn Gly Ala Val Trp Ser Trp 
    50                  55                  60                  


Val Ser Glu Arg Thr Pro Asp Pro Glu Thr Arg Thr Val Arg Ala Arg 
65                  70                  75                  80  


Arg Ile Glu Thr Gly Pro Phe Glu His Met Asp Ile His Trp Thr Tyr 
                85                  90                  95      


Ala Asp Thr Asp Gly Gly Val Glu Met Arg Trp Arg Gln Glu Phe Thr 
            100                 105                 110         


Val Arg Pro Gly Leu Pro Phe Gly Asp Thr Glu Met Thr Glu Arg Leu 
        115                 120                 125             


Asn Thr Asn Thr Arg Arg Glu Met Ala Arg Ile Lys Gly Leu Val Glu 
    130                 135                 140                 


Arg Ala Ala Ala Val Ala Arg 
145                 150     


<210>  38
<211>  474
<212>  DNA
<213>  Streptomyces sp. TA-0256


<220>
<221>  CDS
<222>  (1)..(474)
<223>  pnxD (type: SRPBCC) gene [GenBank ID number AB469194.1 position 
       16730 to 17203] encoding a first 'small molecule foldase'  
       [GenBank ID number BAJ52684.1].

<400>  38
atg ccg gcg aag acg gag aac tcc gtg gtc atc gac gcg ccc atg gac         48
Met Pro Ala Lys Thr Glu Asn Ser Val Val Ile Asp Ala Pro Met Asp           
1               5                   10                  15                

ctg gtg tgg cgg atg acc aac gac gtc gcc tcg tgg ccg tcg ctc ttc         96
Leu Val Trp Arg Met Thr Asn Asp Val Ala Ser Trp Pro Ser Leu Phe           
            20                  25                  30                    

gac gag tac gcg gag gcc gag atc ctc gac acc tcg ccc gac ggg acc        144
Asp Glu Tyr Ala Glu Ala Glu Ile Leu Asp Thr Ser Pro Asp Gly Thr           
        35                  40                  45                        

gtc cgc ttc cgg ctg acg atg ttc ccc gac gag gac ggc aag gtc tgg        192
Val Arg Phe Arg Leu Thr Met Phe Pro Asp Glu Asp Gly Lys Val Trp           
    50                  55                  60                            

agc tgg gtc tcg cag cgc agg gcc gac gcc gcc acc cgg agc gtg cgc        240
Ser Trp Val Ser Gln Arg Arg Ala Asp Ala Ala Thr Arg Ser Val Arg           
65                  70                  75                  80            

gcg cac cgc ctg gag ccg gga ccg ttc gag ttc atg aac atc tcc tgg        288
Ala His Arg Leu Glu Pro Gly Pro Phe Glu Phe Met Asn Ile Ser Trp           
                85                  90                  95                

gac tac cgc gag acc ggc ggc ggc gtg gag atg cgc tgg gtc cag gag        336
Asp Tyr Arg Glu Thr Gly Gly Gly Val Glu Met Arg Trp Val Gln Glu           
            100                 105                 110                   

ttc cgc gta cgg ccc ggg ctg ccc ttc gac gac gag gcg atg acc gcc        384
Phe Arg Val Arg Pro Gly Leu Pro Phe Asp Asp Glu Ala Met Thr Ala           
        115                 120                 125                       

cac ctg aac acc aac acc aag gtc cag atg gcc cgg atc aag aag ctc        432
His Leu Asn Thr Asn Thr Lys Val Gln Met Ala Arg Ile Lys Lys Leu           
    130                 135                 140                           

gtg gag cag gcg gcc ggc cgg tcg gac ggc ccg gac cga tga                474
Val Glu Gln Ala Ala Gly Arg Ser Asp Gly Pro Asp Arg                       
145                 150                 155                               


<210>  39
<211>  157
<212>  PRT
<213>  Streptomyces sp. TA-0256

<400>  39

Met Pro Ala Lys Thr Glu Asn Ser Val Val Ile Asp Ala Pro Met Asp 
1               5                   10                  15      


Leu Val Trp Arg Met Thr Asn Asp Val Ala Ser Trp Pro Ser Leu Phe 
            20                  25                  30          


Asp Glu Tyr Ala Glu Ala Glu Ile Leu Asp Thr Ser Pro Asp Gly Thr 
        35                  40                  45              


Val Arg Phe Arg Leu Thr Met Phe Pro Asp Glu Asp Gly Lys Val Trp 
    50                  55                  60                  


Ser Trp Val Ser Gln Arg Arg Ala Asp Ala Ala Thr Arg Ser Val Arg 
65                  70                  75                  80  


Ala His Arg Leu Glu Pro Gly Pro Phe Glu Phe Met Asn Ile Ser Trp 
                85                  90                  95      


Asp Tyr Arg Glu Thr Gly Gly Gly Val Glu Met Arg Trp Val Gln Glu 
            100                 105                 110         


Phe Arg Val Arg Pro Gly Leu Pro Phe Asp Asp Glu Ala Met Thr Ala 
        115                 120                 125             


His Leu Asn Thr Asn Thr Lys Val Gln Met Ala Arg Ile Lys Lys Leu 
    130                 135                 140                 


Val Glu Gln Ala Ala Gly Arg Ser Asp Gly Pro Asp Arg 
145                 150                 155         


<210>  40
<211>  468
<212>  DNA
<213>  Streptomyces tendae


<220>
<221>  CDS
<222>  (1)..(468)
<223>  llpCI (type: SRPBCC) gene [GenBank ID number AM492533.1 position 
       8866 to 9333] encoding a first 'small molecule foldase' [GenBank 
       ID number CAM34342.1]

<400>  40
atg tca gga cac acc gac aac tcg acc gtc atc gac gca ccg ctg gac         48
Met Ser Gly His Thr Asp Asn Ser Thr Val Ile Asp Ala Pro Leu Asp           
1               5                   10                  15                

ctg gtc tgg gac atg acc aac gac gtg gcc tcg tgg ccg gac ctg ttc         96
Leu Val Trp Asp Met Thr Asn Asp Val Ala Ser Trp Pro Asp Leu Phe           
            20                  25                  30                    

agc gag tac gcc gag gcc acc gtc ctg gag cgg gac ggc aac cgg atc        144
Ser Glu Tyr Ala Glu Ala Thr Val Leu Glu Arg Asp Gly Asn Arg Ile           
        35                  40                  45                        

gtc ttc cgc ctg gcg atg cac ccg gac gcg ggc ggc acc gtg tgg agc        192
Val Phe Arg Leu Ala Met His Pro Asp Ala Gly Gly Thr Val Trp Ser           
    50                  55                  60                            

tgg gtg tcc gaa cgc atc ctc gac ccg gtg gcc cgc acc gtc cac gcc        240
Trp Val Ser Glu Arg Ile Leu Asp Pro Val Ala Arg Thr Val His Ala           
65                  70                  75                  80            

cgc cgg gtg gag acg ggc aac ttc aag tac atg tgg ctg ttc tgg gag        288
Arg Arg Val Glu Thr Gly Asn Phe Lys Tyr Met Trp Leu Phe Trp Glu           
                85                  90                  95                

tac acc acc gag gac gac ggc gta cgg ctg cgc tgg gtg cag gac ttc        336
Tyr Thr Thr Glu Asp Asp Gly Val Arg Leu Arg Trp Val Gln Asp Phe           
            100                 105                 110                   

gaa ctc aag ccc ggc ctg ccc atg gac gat gcc gcg atg acc gac cgg        384
Glu Leu Lys Pro Gly Leu Pro Met Asp Asp Ala Ala Met Thr Asp Arg           
        115                 120                 125                       

ctc aac gcc aac tcg gtc gcc cag ctc gaa ctg atc aag gag aag atc        432
Leu Asn Ala Asn Ser Val Ala Gln Leu Glu Leu Ile Lys Glu Lys Ile           
    130                 135                 140                           

gag gcc gtg gcc cgc gcg acc gcc gcc aca cgc tga                        468
Glu Ala Val Ala Arg Ala Thr Ala Ala Thr Arg                               
145                 150                 155                               


<210>  41
<211>  155
<212>  PRT
<213>  Streptomyces tendae

<400>  41

Met Ser Gly His Thr Asp Asn Ser Thr Val Ile Asp Ala Pro Leu Asp 
1               5                   10                  15      


Leu Val Trp Asp Met Thr Asn Asp Val Ala Ser Trp Pro Asp Leu Phe 
            20                  25                  30          


Ser Glu Tyr Ala Glu Ala Thr Val Leu Glu Arg Asp Gly Asn Arg Ile 
        35                  40                  45              


Val Phe Arg Leu Ala Met His Pro Asp Ala Gly Gly Thr Val Trp Ser 
    50                  55                  60                  


Trp Val Ser Glu Arg Ile Leu Asp Pro Val Ala Arg Thr Val His Ala 
65                  70                  75                  80  


Arg Arg Val Glu Thr Gly Asn Phe Lys Tyr Met Trp Leu Phe Trp Glu 
                85                  90                  95      


Tyr Thr Thr Glu Asp Asp Gly Val Arg Leu Arg Trp Val Gln Asp Phe 
            100                 105                 110         


Glu Leu Lys Pro Gly Leu Pro Met Asp Asp Ala Ala Met Thr Asp Arg 
        115                 120                 125             


Leu Asn Ala Asn Ser Val Ala Gln Leu Glu Leu Ile Lys Glu Lys Ile 
    130                 135                 140                 


Glu Ala Val Ala Arg Ala Thr Ala Ala Thr Arg 
145                 150                 155 


<210>  42
<211>  974
<212>  DNA
<213>  Streptomyces violaceoruber


<220>
<221>  CDS
<222>  (1)..(972)
<223>  gra-orf4 (type: 2xSRPBCC) gene [GenBank ID number AJ011500.1 
       position 32006 to 32980] encoding a first small molecule foldase 
       [GenBank ID number CAA09656]

<400>  42
atg gtc cag ccc gcc gcc acc ccc gtc tcc ctg ccc agc ccc acc gtc         48
Met Val Gln Pro Ala Ala Thr Pro Val Ser Leu Pro Ser Pro Thr Val           
1               5                   10                  15                

cac cgc agc gag cac acc gtg acg gtg gcc gca ccg ccc gag gcg ctc         96
His Arg Ser Glu His Thr Val Thr Val Ala Ala Pro Pro Glu Ala Leu           
            20                  25                  30                    

tac gcg ctc gtc gcc gac gtg acg cgg tgg ccg gcc gtg ttc gag ccg        144
Tyr Ala Leu Val Ala Asp Val Thr Arg Trp Pro Ala Val Phe Glu Pro           
        35                  40                  45                        

acg gtg cac gtg cgg cac ctc gcc cgg gag ggg cgg acc gaa cgg ttc        192
Thr Val His Val Arg His Leu Ala Arg Glu Gly Arg Thr Glu Arg Phe           
    50                  55                  60                            

gag atc tgg gcc gag gtg aac ggc gag atc gcg cac tgg cgt tcg cgc        240
Glu Ile Trp Ala Glu Val Asn Gly Glu Ile Ala His Trp Arg Ser Arg           
65                  70                  75                  80            

cgc gtt ctc gac ccg gtg cgg cgg tac gtg tcg ttc cgt cag gag cac        288
Arg Val Leu Asp Pro Val Arg Arg Tyr Val Ser Phe Arg Gln Glu His           
                85                  90                  95                

agc cgg ccg ccg gtg acc tcg atg tcc gga ggg tgg ctg ttc cgc ccg        336
Ser Arg Pro Pro Val Thr Ser Met Ser Gly Gly Trp Leu Phe Arg Pro           
            100                 105                 110                   

ctg gcc gac ggc cgg acg gag atc gtg ctg cgg cac cgg ttc acc gtc        384
Leu Ala Asp Gly Arg Thr Glu Ile Val Leu Arg His Arg Phe Thr Val           
        115                 120                 125                       

gcc gac gac gac ccg gcc gcc gtg gcc cgt atc gag gag gcc ctc gac        432
Ala Asp Asp Asp Pro Ala Ala Val Ala Arg Ile Glu Glu Ala Leu Asp           
    130                 135                 140                           

cgc aac agc gcc cga gaa ctg ggc gcg ctc gcg gcg ctc gcc gag acc        480
Arg Asn Ser Ala Arg Glu Leu Gly Ala Leu Ala Ala Leu Ala Glu Thr           
145                 150                 155                 160           

ggg cac ccg gtg gac gaa ctg gtc ttc tcc ttc acg gac acc ctc ccg        528
Gly His Pro Val Asp Glu Leu Val Phe Ser Phe Thr Asp Thr Leu Pro           
                165                 170                 175               

ctc cag ggc gcc gcc cgg gac gcg tac acc ttc gtc gag cgt gcc gag        576
Leu Gln Gly Ala Ala Arg Asp Ala Tyr Thr Phe Val Glu Arg Ala Glu           
            180                 185                 190                   

cgc tgg gcc gag ctg ctg ccg cac gtc gcc caa tgt ggt gct gac cga        624
Arg Trp Ala Glu Leu Leu Pro His Val Ala Gln Cys Gly Ala Asp Arg           
        195                 200                 205                       

gcc gga acc ggg ctc gag cag tgg ctg gag atg gac acc gtg acg gcc        672
Ala Gly Thr Gly Leu Glu Gln Trp Leu Glu Met Asp Thr Val Thr Ala           
    210                 215                 220                           

gac ggg tcc acc cac acc acc agg tcg gcg cgc atc tgc cgg gcg ccc        720
Asp Gly Ser Thr His Thr Thr Arg Ser Ala Arg Ile Cys Arg Ala Pro           
225                 230                 235                 240           

gag tgg atc gcg tac aac gag cag cgc acc ccc cgg ctc gtg tcc ggc        768
Glu Trp Ile Ala Tyr Asn Glu Gln Arg Thr Pro Arg Leu Val Ser Gly           
                245                 250                 255               

cac agc ggc gag tgg acg ttc gcc cag acc ccc gag ggt ccc gtg gcg        816
His Ser Gly Glu Trp Thr Phe Ala Gln Thr Pro Glu Gly Pro Val Ala           
            260                 265                 270                   

acc gcc cgc cac acc gtc gcc gtc gac ccg agc ggc atc acc gag gtc        864
Thr Ala Arg His Thr Val Ala Val Asp Pro Ser Gly Ile Thr Glu Val           
        275                 280                 285                       

ctc ggc ccg gac gcc acc ctc gcc gac gcc cgg gcc tac ctc cgc gac        912
Leu Gly Pro Asp Ala Thr Leu Ala Asp Ala Arg Ala Tyr Leu Arg Asp           
    290                 295                 300                           

gcc ctg ggc cgc aac agc ctg gcc acg ctg cgg cac gcc gcc gaa gcg        960
Ala Leu Gly Arg Asn Ser Leu Ala Thr Leu Arg His Ala Ala Glu Ala           
305                 310                 315                 320           

gcc cag cgg gcg ta                                                     974
Ala Gln Arg Ala                                                           
                                                                          


<210>  43
<211>  324
<212>  PRT
<213>  Streptomyces violaceoruber

<400>  43

Met Val Gln Pro Ala Ala Thr Pro Val Ser Leu Pro Ser Pro Thr Val 
1               5                   10                  15      


His Arg Ser Glu His Thr Val Thr Val Ala Ala Pro Pro Glu Ala Leu 
            20                  25                  30          


Tyr Ala Leu Val Ala Asp Val Thr Arg Trp Pro Ala Val Phe Glu Pro 
        35                  40                  45              


Thr Val His Val Arg His Leu Ala Arg Glu Gly Arg Thr Glu Arg Phe 
    50                  55                  60                  


Glu Ile Trp Ala Glu Val Asn Gly Glu Ile Ala His Trp Arg Ser Arg 
65                  70                  75                  80  


Arg Val Leu Asp Pro Val Arg Arg Tyr Val Ser Phe Arg Gln Glu His 
                85                  90                  95      


Ser Arg Pro Pro Val Thr Ser Met Ser Gly Gly Trp Leu Phe Arg Pro 
            100                 105                 110         


Leu Ala Asp Gly Arg Thr Glu Ile Val Leu Arg His Arg Phe Thr Val 
        115                 120                 125             


Ala Asp Asp Asp Pro Ala Ala Val Ala Arg Ile Glu Glu Ala Leu Asp 
    130                 135                 140                 


Arg Asn Ser Ala Arg Glu Leu Gly Ala Leu Ala Ala Leu Ala Glu Thr 
145                 150                 155                 160 


Gly His Pro Val Asp Glu Leu Val Phe Ser Phe Thr Asp Thr Leu Pro 
                165                 170                 175     


Leu Gln Gly Ala Ala Arg Asp Ala Tyr Thr Phe Val Glu Arg Ala Glu 
            180                 185                 190         


Arg Trp Ala Glu Leu Leu Pro His Val Ala Gln Cys Gly Ala Asp Arg 
        195                 200                 205             


Ala Gly Thr Gly Leu Glu Gln Trp Leu Glu Met Asp Thr Val Thr Ala 
    210                 215                 220                 


Asp Gly Ser Thr His Thr Thr Arg Ser Ala Arg Ile Cys Arg Ala Pro 
225                 230                 235                 240 


Glu Trp Ile Ala Tyr Asn Glu Gln Arg Thr Pro Arg Leu Val Ser Gly 
                245                 250                 255     


His Ser Gly Glu Trp Thr Phe Ala Gln Thr Pro Glu Gly Pro Val Ala 
            260                 265                 270         


Thr Ala Arg His Thr Val Ala Val Asp Pro Ser Gly Ile Thr Glu Val 
        275                 280                 285             


Leu Gly Pro Asp Ala Thr Leu Ala Asp Ala Arg Ala Tyr Leu Arg Asp 
    290                 295                 300                 


Ala Leu Gly Arg Asn Ser Leu Ala Thr Leu Arg His Ala Ala Glu Ala 
305                 310                 315                 320 


Ala Gln Arg Ala 
                


<210>  44
<211>  954
<212>  DNA
<213>  Streptomyces fulvissimus


<220>
<221>  CDS
<222>  (1)..(954)
<223>  schP4/SFUL_4006 (type: 2xSRPBCC) gene [GenBank ID number 
       CP005080.1 Position 4477979 to 4478932]) encoding a first small 
       molecule foldase [GenBank ID number AGK78908.1]

<400>  44
atg aag agc atg acc gac tcc cga ccg cgc gag gtg gag cac gag atc         48
Met Lys Ser Met Thr Asp Ser Arg Pro Arg Glu Val Glu His Glu Ile           
1               5                   10                  15                

acg gtc tcc gcc ccg gcc gca gag gtg tac cgg ctg atc gcc gag gtc         96
Thr Val Ser Ala Pro Ala Ala Glu Val Tyr Arg Leu Ile Ala Glu Val           
            20                  25                  30                    

gag aac tgg ccg cgg atc ttc ccg ccg acc atc tac gtc gac cac atc        144
Glu Asn Trp Pro Arg Ile Phe Pro Pro Thr Ile Tyr Val Asp His Ile           
        35                  40                  45                        

gag cgc tcc gag ggc gag gag ctc atc cgg atc tgg gcc acg gcc aac        192
Glu Arg Ser Glu Gly Glu Glu Leu Ile Arg Ile Trp Ala Thr Ala Asn           
    50                  55                  60                            

ggc gag gcc aag aac tgg act tcg cgc cgc ttc ctg gac cgg gag gcg        240
Gly Glu Ala Lys Asn Trp Thr Ser Arg Arg Phe Leu Asp Arg Glu Ala           
65                  70                  75                  80            

atg cgc atc acc ttc cgc cag cag gtc tcg acc ccg ccc gtc gcc acg        288
Met Arg Ile Thr Phe Arg Gln Gln Val Ser Thr Pro Pro Val Ala Thr           
                85                  90                  95                

atg ggc ggc acc tgg atc atc gag cca ctc tcc gcc acc gag tcg cgg        336
Met Gly Gly Thr Trp Ile Ile Glu Pro Leu Ser Ala Thr Glu Ser Arg           
            100                 105                 110                   

atc cgg ctc cag cac gac tac acc gcc gtg gac gac gac ccg gcc ggg        384
Ile Arg Leu Gln His Asp Tyr Thr Ala Val Asp Asp Asp Pro Ala Gly           
        115                 120                 125                       

ctc gcc tgg atc gag gag gcc gtc gac cgc aac tcg cgc tcc gag ctg        432
Leu Ala Trp Ile Glu Glu Ala Val Asp Arg Asn Ser Arg Ser Glu Leu           
    130                 135                 140                           

gcc gcc ctg aag acc aac gtc gaa ctg gcc acg gcc tcg gag gag ttg        480
Ala Ala Leu Lys Thr Asn Val Glu Leu Ala Thr Ala Ser Glu Glu Leu           
145                 150                 155                 160           

acc ttc gcc ttc gag gac acc gtc gag atc gcc ggc tcc gcc aag gac        528
Thr Phe Ala Phe Glu Asp Thr Val Glu Ile Ala Gly Ser Ala Lys Asp           
                165                 170                 175               

gcc tac gac ttc atc aac gag gcc ggg ctc tgg tcg gag cgg ctg ccg        576
Ala Tyr Asp Phe Ile Asn Glu Ala Gly Leu Trp Ser Glu Arg Leu Pro           
            180                 185                 190                   

cac gtg gcc gtc gtc cgg ctc acc gag gac agc ccc ggg ctc cag acc        624
His Val Ala Val Val Arg Leu Thr Glu Asp Ser Pro Gly Leu Gln Thr           
        195                 200                 205                       

ctg gag atg gac acc cgc gcc aag gac ggc tcc gtg cac acg acg aag        672
Leu Glu Met Asp Thr Arg Ala Lys Asp Gly Ser Val His Thr Thr Lys           
    210                 215                 220                           

tcg tac cgg gtc tgc ctg aac ggc gag aag atc gcg tac aaa cag acc        720
Ser Tyr Arg Val Cys Leu Asn Gly Glu Lys Ile Ala Tyr Lys Gln Thr           
225                 230                 235                 240           

acc ctg ccc gcc ctg atg aac ctg cac acc ggt gtc tgg acc ttc cgg        768
Thr Leu Pro Ala Leu Met Asn Leu His Thr Gly Val Trp Thr Phe Arg           
                245                 250                 255               

gag acc ggt gcc ggg gtc gcc gcc acc tcc cag cac acc gtg gtc atc        816
Glu Thr Gly Ala Gly Val Ala Ala Thr Ser Gln His Thr Val Val Ile           
            260                 265                 270                   

cgg gcc gag aac atc gag aag atc ctc ggt cct gag gcg gac gtc gcg        864
Arg Ala Glu Asn Ile Glu Lys Ile Leu Gly Pro Glu Ala Asp Val Ala           
        275                 280                 285                       

cag gcg cgg gag tac gtg aag gcg gcg ctc agc acc aac agc cgc gcc        912
Gln Ala Arg Glu Tyr Val Lys Ala Ala Leu Ser Thr Asn Ser Arg Ala           
    290                 295                 300                           

acc ctc ggc cac gcc aag gac tac gcc gaa gcg cgg cgc tga                954
Thr Leu Gly His Ala Lys Asp Tyr Ala Glu Ala Arg Arg                       
305                 310                 315                               


<210>  45
<211>  317
<212>  PRT
<213>  Streptomyces fulvissimus

<400>  45

Met Lys Ser Met Thr Asp Ser Arg Pro Arg Glu Val Glu His Glu Ile 
1               5                   10                  15      


Thr Val Ser Ala Pro Ala Ala Glu Val Tyr Arg Leu Ile Ala Glu Val 
            20                  25                  30          


Glu Asn Trp Pro Arg Ile Phe Pro Pro Thr Ile Tyr Val Asp His Ile 
        35                  40                  45              


Glu Arg Ser Glu Gly Glu Glu Leu Ile Arg Ile Trp Ala Thr Ala Asn 
    50                  55                  60                  


Gly Glu Ala Lys Asn Trp Thr Ser Arg Arg Phe Leu Asp Arg Glu Ala 
65                  70                  75                  80  


Met Arg Ile Thr Phe Arg Gln Gln Val Ser Thr Pro Pro Val Ala Thr 
                85                  90                  95      


Met Gly Gly Thr Trp Ile Ile Glu Pro Leu Ser Ala Thr Glu Ser Arg 
            100                 105                 110         


Ile Arg Leu Gln His Asp Tyr Thr Ala Val Asp Asp Asp Pro Ala Gly 
        115                 120                 125             


Leu Ala Trp Ile Glu Glu Ala Val Asp Arg Asn Ser Arg Ser Glu Leu 
    130                 135                 140                 


Ala Ala Leu Lys Thr Asn Val Glu Leu Ala Thr Ala Ser Glu Glu Leu 
145                 150                 155                 160 


Thr Phe Ala Phe Glu Asp Thr Val Glu Ile Ala Gly Ser Ala Lys Asp 
                165                 170                 175     


Ala Tyr Asp Phe Ile Asn Glu Ala Gly Leu Trp Ser Glu Arg Leu Pro 
            180                 185                 190         


His Val Ala Val Val Arg Leu Thr Glu Asp Ser Pro Gly Leu Gln Thr 
        195                 200                 205             


Leu Glu Met Asp Thr Arg Ala Lys Asp Gly Ser Val His Thr Thr Lys 
    210                 215                 220                 


Ser Tyr Arg Val Cys Leu Asn Gly Glu Lys Ile Ala Tyr Lys Gln Thr 
225                 230                 235                 240 


Thr Leu Pro Ala Leu Met Asn Leu His Thr Gly Val Trp Thr Phe Arg 
                245                 250                 255     


Glu Thr Gly Ala Gly Val Ala Ala Thr Ser Gln His Thr Val Val Ile 
            260                 265                 270         


Arg Ala Glu Asn Ile Glu Lys Ile Leu Gly Pro Glu Ala Asp Val Ala 
        275                 280                 285             


Gln Ala Arg Glu Tyr Val Lys Ala Ala Leu Ser Thr Asn Ser Arg Ala 
    290                 295                 300                 


Thr Leu Gly His Ala Lys Asp Tyr Ala Glu Ala Arg Arg 
305                 310                 315         


<210>  46
<211>  951
<212>  DNA
<213>  soil bacterium V167


<220>
<221>  CDS
<222>  (1)..(951)
<223>  Erd4 (bifunc) (type: 2xSRPBCC) gene [GenBank ID number FJ719113.1
       Position 3913 to 4863) encoding a first small molecule foldase 
       [GenBank ID number ACX83620.1]

<400>  46
atg acc acg atc cac cgc acc gag cac acc ctg gtc gtc gac gcc ccg         48
Met Thr Thr Ile His Arg Thr Glu His Thr Leu Val Val Asp Ala Pro           
1               5                   10                  15                

ccg cgc acc ctc tac gac ctg gtc gcc gac acc acc cgc tgg ccg gcg         96
Pro Arg Thr Leu Tyr Asp Leu Val Ala Asp Thr Thr Arg Trp Pro Ala           
            20                  25                  30                    

atc ttc ggc ccc agc gtc cac gtc cac cac ctg gag cac ggt gag cgc        144
Ile Phe Gly Pro Ser Val His Val His His Leu Glu His Gly Glu Arg           
        35                  40                  45                        

gac gag cgc ttc gag atc tgg gcg cag gtc aac ggc gag gtg gtc agc        192
Asp Glu Arg Phe Glu Ile Trp Ala Gln Val Asn Gly Glu Val Val Ser           
    50                  55                  60                            

tgg gtc tcc cgc cgc gtc ctg gac ccc gaa cgg ctc tac atc gcc ttc        240
Trp Val Ser Arg Arg Val Leu Asp Pro Glu Arg Leu Tyr Ile Ala Phe           
65                  70                  75                  80            

cgg cag gag cgc agc gca cct ccg ttc gcc tcc atg agc ggc ggc tgg        288
Arg Gln Glu Arg Ser Ala Pro Pro Phe Ala Ser Met Ser Gly Gly Trp           
                85                  90                  95                

ctc ttc cgc gcc ctg ccc gga ggc cgc acc gag gtg gtg ctg cgg cac        336
Leu Phe Arg Ala Leu Pro Gly Gly Arg Thr Glu Val Val Leu Arg His           
            100                 105                 110                   

cgg ttc gcc gcg ctc gac gag gac ccg gcg acc ctg gag cgg atc cac        384
Arg Phe Ala Ala Leu Asp Glu Asp Pro Ala Thr Leu Glu Arg Ile His           
        115                 120                 125                       

cgg gcg ctc gac cgc aac agc ccc cag gag ctc gcc gcg ctc gcc cgg        432
Arg Ala Leu Asp Arg Asn Ser Pro Gln Glu Leu Ala Ala Leu Ala Arg           
    130                 135                 140                           

atc gcc caa ctc ggc acc gat gtc gag gag gtg gtg ttc tcc ttc acc        480
Ile Ala Gln Leu Gly Thr Asp Val Glu Glu Val Val Phe Ser Phe Thr           
145                 150                 155                 160           

gac acc gtg ccg ctg acc ggc acg gcg gcc gcc gcg tac gcc ttc gtc        528
Asp Thr Val Pro Leu Thr Gly Thr Ala Ala Ala Ala Tyr Ala Phe Val           
                165                 170                 175               

gac cgc gcc gac ctg tgg gcg gag cgt ctc ccg cac gtc tcc cgc gcc        576
Asp Arg Ala Asp Leu Trp Ala Glu Arg Leu Pro His Val Ser Arg Ala           
            180                 185                 190                   

cgt ctc acc gag gac gtc ccg ggc atc cag acc ctg gag atg gac acc        624
Arg Leu Thr Glu Asp Val Pro Gly Ile Gln Thr Leu Glu Met Asp Thr           
        195                 200                 205                       

gtc acc gcc gac ggc agc gcg cac cgc acc cgg tcg gtg cgc gtc tgc        672
Val Thr Ala Asp Gly Ser Ala His Arg Thr Arg Ser Val Arg Val Cys           
    210                 215                 220                           

cgg gag ccg agc tgg atc gcg tac aag cag ctg gag atg ccg cgg ctg        720
Arg Glu Pro Ser Trp Ile Ala Tyr Lys Gln Leu Glu Met Pro Arg Leu           
225                 230                 235                 240           

ctg agc ggg cac agc ggg ctg tgg acc ttc acg gac ggg ccg gac ggc        768
Leu Ser Gly His Ser Gly Leu Trp Thr Phe Thr Asp Gly Pro Asp Gly           
                245                 250                 255               

ccg gtc gcc gtc tcc cgg cac acg gtg gcg atc gac ccg tcg gcc gtc        816
Pro Val Ala Val Ser Arg His Thr Val Ala Ile Asp Pro Ser Ala Val           
            260                 265                 270                   

gag gag gtg ctg ggc gcg ggg gcc acg ctc gcc gac gcg cgc cgg tat        864
Glu Glu Val Leu Gly Ala Gly Ala Thr Leu Ala Asp Ala Arg Arg Tyr           
        275                 280                 285                       

ctc cgc gag gcg ctg ggc cgc aac agc ctg acc acg atg acg cac gcg        912
Leu Arg Glu Ala Leu Gly Arg Asn Ser Leu Thr Thr Met Thr His Ala           
    290                 295                 300                           

gcg gcc tac gcg cag gag cac ggc agc gcg gtg cgc tga                    951
Ala Ala Tyr Ala Gln Glu His Gly Ser Ala Val Arg                           
305                 310                 315                               


<210>  47
<211>  316
<212>  PRT
<213>  soil bacterium V167

<400>  47

Met Thr Thr Ile His Arg Thr Glu His Thr Leu Val Val Asp Ala Pro 
1               5                   10                  15      


Pro Arg Thr Leu Tyr Asp Leu Val Ala Asp Thr Thr Arg Trp Pro Ala 
            20                  25                  30          


Ile Phe Gly Pro Ser Val His Val His His Leu Glu His Gly Glu Arg 
        35                  40                  45              


Asp Glu Arg Phe Glu Ile Trp Ala Gln Val Asn Gly Glu Val Val Ser 
    50                  55                  60                  


Trp Val Ser Arg Arg Val Leu Asp Pro Glu Arg Leu Tyr Ile Ala Phe 
65                  70                  75                  80  


Arg Gln Glu Arg Ser Ala Pro Pro Phe Ala Ser Met Ser Gly Gly Trp 
                85                  90                  95      


Leu Phe Arg Ala Leu Pro Gly Gly Arg Thr Glu Val Val Leu Arg His 
            100                 105                 110         


Arg Phe Ala Ala Leu Asp Glu Asp Pro Ala Thr Leu Glu Arg Ile His 
        115                 120                 125             


Arg Ala Leu Asp Arg Asn Ser Pro Gln Glu Leu Ala Ala Leu Ala Arg 
    130                 135                 140                 


Ile Ala Gln Leu Gly Thr Asp Val Glu Glu Val Val Phe Ser Phe Thr 
145                 150                 155                 160 


Asp Thr Val Pro Leu Thr Gly Thr Ala Ala Ala Ala Tyr Ala Phe Val 
                165                 170                 175     


Asp Arg Ala Asp Leu Trp Ala Glu Arg Leu Pro His Val Ser Arg Ala 
            180                 185                 190         


Arg Leu Thr Glu Asp Val Pro Gly Ile Gln Thr Leu Glu Met Asp Thr 
        195                 200                 205             


Val Thr Ala Asp Gly Ser Ala His Arg Thr Arg Ser Val Arg Val Cys 
    210                 215                 220                 


Arg Glu Pro Ser Trp Ile Ala Tyr Lys Gln Leu Glu Met Pro Arg Leu 
225                 230                 235                 240 


Leu Ser Gly His Ser Gly Leu Trp Thr Phe Thr Asp Gly Pro Asp Gly 
                245                 250                 255     


Pro Val Ala Val Ser Arg His Thr Val Ala Ile Asp Pro Ser Ala Val 
            260                 265                 270         


Glu Glu Val Leu Gly Ala Gly Ala Thr Leu Ala Asp Ala Arg Arg Tyr 
        275                 280                 285             


Leu Arg Glu Ala Leu Gly Arg Asn Ser Leu Thr Thr Met Thr His Ala 
    290                 295                 300                 


Ala Ala Tyr Ala Gln Glu His Gly Ser Ala Val Arg 
305                 310                 315     


<210>  48
<211>  957
<212>  DNA
<213>  Streptomyces sp. AM-7161


<220>
<221>  CDS
<222>  (1)..(957)
<223>  med-ORF19 (type: 2xSRPBCC) gene [GenBank ID number AB103463.1 
       Position 13942 to 14898) encoding a first small molecule foldase 
       [GenBank ID number BAC79027]

<400>  48
atg acc cag ccc acc cca cgg gag acc gcc cac gag atc acc gtc cgc         48
Met Thr Gln Pro Thr Pro Arg Glu Thr Ala His Glu Ile Thr Val Arg           
1               5                   10                  15                

gcg acg gcc gag cgg ctc tac gaa ctg atc gcc gac gtc ggc ggc tgg         96
Ala Thr Ala Glu Arg Leu Tyr Glu Leu Ile Ala Asp Val Gly Gly Trp           
            20                  25                  30                    

ccc tcg atc ttc ccg ccc tcg gtc cac gcc gac cac ctg gag cgc ggc        144
Pro Ser Ile Phe Pro Pro Ser Val His Ala Asp His Leu Glu Arg Gly           
        35                  40                  45                        

gac aag gag gag cgc atc cgg ctc tgg gcc acc gtc gac ggg cag gtc        192
Asp Lys Glu Glu Arg Ile Arg Leu Trp Ala Thr Val Asp Gly Gln Val           
    50                  55                  60                            

aag cac tgg acg tcc cgg cgc acc ctg gac cgc gca gga ctc cgc gtc        240
Lys His Trp Thr Ser Arg Arg Thr Leu Asp Arg Ala Gly Leu Arg Val           
65                  70                  75                  80            

gac ttc cgg cag gag gtg ccg agt ccg ccg atg gcc gcg atg ggc ggt        288
Asp Phe Arg Gln Glu Val Pro Ser Pro Pro Met Ala Ala Met Gly Gly           
                85                  90                  95                

gcc tgg atc atc gaa ccc acg gga ccg ggg gag tgc cgc gta cgg ctg        336
Ala Trp Ile Ile Glu Pro Thr Gly Pro Gly Glu Cys Arg Val Arg Leu           
            100                 105                 110                   

ctg cac gac ttc cgg gcc gtc ggc gac gac ccc ggg acc ctc gac tgg        384
Leu His Asp Phe Arg Ala Val Gly Asp Asp Pro Gly Thr Leu Asp Trp           
        115                 120                 125                       

atc gac cgc gcc gtg gac gcc aac agc cgg tcg gag ctc gcc gcc ctc        432
Ile Asp Arg Ala Val Asp Ala Asn Ser Arg Ser Glu Leu Ala Ala Leu           
    130                 135                 140                           

aag cgc cac gcc gaa cgc ggc gcc gac ggc ccg ggc gag ggc gac acc        480
Lys Arg His Ala Glu Arg Gly Ala Asp Gly Pro Gly Glu Gly Asp Thr           
145                 150                 155                 160           

ttc ctc acc ttc gag gac acc gtc cgc ctc gaa ggc cac gtc aag gac        528
Phe Leu Thr Phe Glu Asp Thr Val Arg Leu Glu Gly His Val Lys Asp           
                165                 170                 175               

gtc tac gac ttc atc gac cag gcc cag cac tgg gcc gac cgc ctg ccc        576
Val Tyr Asp Phe Ile Asp Gln Ala Gln His Trp Ala Asp Arg Leu Pro           
            180                 185                 190                   

cac gtc acg tcc gtg aac ctg cgg gac gcc ggc ccc ggc cgt cag atc        624
His Val Thr Ser Val Asn Leu Arg Asp Ala Gly Pro Gly Arg Gln Ile           
        195                 200                 205                       

ctg gcc atg gac acg ctc acc aag gac ggc agc ccg cac acc acc gag        672
Leu Ala Met Asp Thr Leu Thr Lys Asp Gly Ser Pro His Thr Thr Glu           
    210                 215                 220                           

tcg gtg cgc gtc tgc gtc ccg tac gag cgg atc gtc tac aag cag acc        720
Ser Val Arg Val Cys Val Pro Tyr Glu Arg Ile Val Tyr Lys Gln Thr           
225                 230                 235                 240           

acc ctg ccc ccg ctg atg gcc ctg cac acc ggc gag tgg agc ttc gcg        768
Thr Leu Pro Pro Leu Met Ala Leu His Thr Gly Glu Trp Ser Phe Ala           
                245                 250                 255               

gag gac ggc gcc ggc gcc acc gtc gtc acc tcg cgc cac acc gcc gtg        816
Glu Asp Gly Ala Gly Ala Thr Val Val Thr Ser Arg His Thr Ala Val           
            260                 265                 270                   

gtc gag ccc gcc gcc gtc acc cgg gtc ctc ggc gag acc gcc gac ctg        864
Val Glu Pro Ala Ala Val Thr Arg Val Leu Gly Glu Thr Ala Asp Leu           
        275                 280                 285                       

ccg gcg gcg cgt cgc tac ctc cgc gag gcg ctg ggt gcg aac agc ctg        912
Pro Ala Ala Arg Arg Tyr Leu Arg Glu Ala Leu Gly Ala Asn Ser Leu           
    290                 295                 300                           

gcc acg ctg agg cac gcc gga gag tac gcc gcg gcc cgc cgc tga            957
Ala Thr Leu Arg His Ala Gly Glu Tyr Ala Ala Ala Arg Arg                   
305                 310                 315                               


<210>  49
<211>  318
<212>  PRT
<213>  Streptomyces sp. AM-7161

<400>  49

Met Thr Gln Pro Thr Pro Arg Glu Thr Ala His Glu Ile Thr Val Arg 
1               5                   10                  15      


Ala Thr Ala Glu Arg Leu Tyr Glu Leu Ile Ala Asp Val Gly Gly Trp 
            20                  25                  30          


Pro Ser Ile Phe Pro Pro Ser Val His Ala Asp His Leu Glu Arg Gly 
        35                  40                  45              


Asp Lys Glu Glu Arg Ile Arg Leu Trp Ala Thr Val Asp Gly Gln Val 
    50                  55                  60                  


Lys His Trp Thr Ser Arg Arg Thr Leu Asp Arg Ala Gly Leu Arg Val 
65                  70                  75                  80  


Asp Phe Arg Gln Glu Val Pro Ser Pro Pro Met Ala Ala Met Gly Gly 
                85                  90                  95      


Ala Trp Ile Ile Glu Pro Thr Gly Pro Gly Glu Cys Arg Val Arg Leu 
            100                 105                 110         


Leu His Asp Phe Arg Ala Val Gly Asp Asp Pro Gly Thr Leu Asp Trp 
        115                 120                 125             


Ile Asp Arg Ala Val Asp Ala Asn Ser Arg Ser Glu Leu Ala Ala Leu 
    130                 135                 140                 


Lys Arg His Ala Glu Arg Gly Ala Asp Gly Pro Gly Glu Gly Asp Thr 
145                 150                 155                 160 


Phe Leu Thr Phe Glu Asp Thr Val Arg Leu Glu Gly His Val Lys Asp 
                165                 170                 175     


Val Tyr Asp Phe Ile Asp Gln Ala Gln His Trp Ala Asp Arg Leu Pro 
            180                 185                 190         


His Val Thr Ser Val Asn Leu Arg Asp Ala Gly Pro Gly Arg Gln Ile 
        195                 200                 205             


Leu Ala Met Asp Thr Leu Thr Lys Asp Gly Ser Pro His Thr Thr Glu 
    210                 215                 220                 


Ser Val Arg Val Cys Val Pro Tyr Glu Arg Ile Val Tyr Lys Gln Thr 
225                 230                 235                 240 


Thr Leu Pro Pro Leu Met Ala Leu His Thr Gly Glu Trp Ser Phe Ala 
                245                 250                 255     


Glu Asp Gly Ala Gly Ala Thr Val Val Thr Ser Arg His Thr Ala Val 
            260                 265                 270         


Val Glu Pro Ala Ala Val Thr Arg Val Leu Gly Glu Thr Ala Asp Leu 
        275                 280                 285             


Pro Ala Ala Arg Arg Tyr Leu Arg Glu Ala Leu Gly Ala Asn Ser Leu 
    290                 295                 300                 


Ala Thr Leu Arg His Ala Gly Glu Tyr Ala Ala Ala Arg Arg 
305                 310                 315             


<210>  50
<211>  944
<212>  DNA
<213>  Streptomyces sp. SF2575


<220>
<221>  CDS
<222>  (1)..(942)
<223>  ssfY1 (type: 2xSRPBCC) gene [GenBank ID number GQ409537.1 
       Position 9830 to 10774) encoding a first small molecule foldase 
       [GenBank ID number ADE34490.1]

<400>  50
atg tcc act ggg cag tcc cgg cac acc agc cac gag atc gag atc gat         48
Met Ser Thr Gly Gln Ser Arg His Thr Ser His Glu Ile Glu Ile Asp           
1               5                   10                  15                

gcc ccc gcc gac gtg gtc tac cgg gtg atc gcg gac gtc acc gcg tgg         96
Ala Pro Ala Asp Val Val Tyr Arg Val Ile Ala Asp Val Thr Ala Trp           
            20                  25                  30                    

ccc ctg cac ttc gcg ccg acg atc cgc gtc gag cag acg caa ctt gac        144
Pro Leu His Phe Ala Pro Thr Ile Arg Val Glu Gln Thr Gln Leu Asp           
        35                  40                  45                        

gac tcc gcc gag cgg ctg cgg atc tgg gcc acc gcc aac ggc gag gtc        192
Asp Ser Ala Glu Arg Leu Arg Ile Trp Ala Thr Ala Asn Gly Glu Val           
    50                  55                  60                            

aag acc tgg acc tcg cgc cgg gtg cac gac aag gcc gcc cgc cgg gtg        240
Lys Thr Trp Thr Ser Arg Arg Val His Asp Lys Ala Ala Arg Arg Val           
65                  70                  75                  80            

gag ttc cgc cag gag gtg tcc tcg gcg ccg gtg gcg gcg atg gcc ggc        288
Glu Phe Arg Gln Glu Val Ser Ser Ala Pro Val Ala Ala Met Ala Gly           
                85                  90                  95                

acc tgg atc gcc gag gca cgc ccc gag ggc ggc acc cgg ctg gtg ctc        336
Thr Trp Ile Ala Glu Ala Arg Pro Glu Gly Gly Thr Arg Leu Val Leu           
            100                 105                 110                   

acc cac gac ttc gcc gcc gtc gac gac gac ccg gcg ggc ctg gag tgg        384
Thr His Asp Phe Ala Ala Val Asp Asp Asp Pro Ala Gly Leu Glu Trp           
        115                 120                 125                       

atc acc cag gcc acc gac cgc aac agc gcc acc gaa ctg ggc aac atc        432
Ile Thr Gln Ala Thr Asp Arg Asn Ser Ala Thr Glu Leu Gly Asn Ile           
    130                 135                 140                           

aag gcg gtc gcg gag cgc tgg gag cgg ctg ggc gaa ctg gtc ttc tcc        480
Lys Ala Val Ala Glu Arg Trp Glu Arg Leu Gly Glu Leu Val Phe Ser           
145                 150                 155                 160           

ttc gag gac tcg gtc gtc atc cag ggc tcc gcc aag gag gtc tac gac        528
Phe Glu Asp Ser Val Val Ile Gln Gly Ser Ala Lys Glu Val Tyr Asp           
                165                 170                 175               

ttc ctc tac cag gcg tcc gag tgg ccg aag cgg ctg ccg cac gtg gcg        576
Phe Leu Tyr Gln Ala Ser Glu Trp Pro Lys Arg Leu Pro His Val Ala           
            180                 185                 190                   

cgc ctc gac ctc ggc gag gac gtg ccc ggc ctg cag acg atg tcg atg        624
Arg Leu Asp Leu Gly Glu Asp Val Pro Gly Leu Gln Thr Met Ser Met           
        195                 200                 205                       

gac acc ctc gcc cag gac ggc tcg gtg cac acc acg gag tcg atc agg        672
Asp Thr Leu Ala Gln Asp Gly Ser Val His Thr Thr Glu Ser Ile Arg           
    210                 215                 220                           

atc tgc atg ccc gac gag ctg aag atc gcc tac aag cag ctc gtg ccg        720
Ile Cys Met Pro Asp Glu Leu Lys Ile Ala Tyr Lys Gln Leu Val Pro           
225                 230                 235                 240           

ccg tcg ctg atg acc gcg cac atc ggc gag tgg acg atc acc gac acc        768
Pro Ser Leu Met Thr Ala His Ile Gly Glu Trp Thr Ile Thr Asp Thr           
                245                 250                 255               

gac gag ggc gtg ctc gcg gtc tcc cag cac acg gtg acc gtc aac gag        816
Asp Glu Gly Val Leu Ala Val Ser Gln His Thr Val Thr Val Asn Glu           
            260                 265                 270                   

gcg aac atc acc aag gtg ctg ggc gag gcg ggc acg gtg gcc tcc gcc        864
Ala Asn Ile Thr Lys Val Leu Gly Glu Ala Gly Thr Val Ala Ser Ala           
        275                 280                 285                       

cgg gac ttc atc cgc cgc gcc gcc ggc ggc aac agc ctg tcc acg ctc        912
Arg Asp Phe Ile Arg Arg Ala Ala Gly Gly Asn Ser Leu Ser Thr Leu           
    290                 295                 300                           

aag cac gcc aag gcg ttc gtg gag gcc ggc tg                             944
Lys His Ala Lys Ala Phe Val Glu Ala Gly                                   
305                 310                                                   


<210>  51
<211>  314
<212>  PRT
<213>  Streptomyces sp. SF2575

<400>  51

Met Ser Thr Gly Gln Ser Arg His Thr Ser His Glu Ile Glu Ile Asp 
1               5                   10                  15      


Ala Pro Ala Asp Val Val Tyr Arg Val Ile Ala Asp Val Thr Ala Trp 
            20                  25                  30          


Pro Leu His Phe Ala Pro Thr Ile Arg Val Glu Gln Thr Gln Leu Asp 
        35                  40                  45              


Asp Ser Ala Glu Arg Leu Arg Ile Trp Ala Thr Ala Asn Gly Glu Val 
    50                  55                  60                  


Lys Thr Trp Thr Ser Arg Arg Val His Asp Lys Ala Ala Arg Arg Val 
65                  70                  75                  80  


Glu Phe Arg Gln Glu Val Ser Ser Ala Pro Val Ala Ala Met Ala Gly 
                85                  90                  95      


Thr Trp Ile Ala Glu Ala Arg Pro Glu Gly Gly Thr Arg Leu Val Leu 
            100                 105                 110         


Thr His Asp Phe Ala Ala Val Asp Asp Asp Pro Ala Gly Leu Glu Trp 
        115                 120                 125             


Ile Thr Gln Ala Thr Asp Arg Asn Ser Ala Thr Glu Leu Gly Asn Ile 
    130                 135                 140                 


Lys Ala Val Ala Glu Arg Trp Glu Arg Leu Gly Glu Leu Val Phe Ser 
145                 150                 155                 160 


Phe Glu Asp Ser Val Val Ile Gln Gly Ser Ala Lys Glu Val Tyr Asp 
                165                 170                 175     


Phe Leu Tyr Gln Ala Ser Glu Trp Pro Lys Arg Leu Pro His Val Ala 
            180                 185                 190         


Arg Leu Asp Leu Gly Glu Asp Val Pro Gly Leu Gln Thr Met Ser Met 
        195                 200                 205             


Asp Thr Leu Ala Gln Asp Gly Ser Val His Thr Thr Glu Ser Ile Arg 
    210                 215                 220                 


Ile Cys Met Pro Asp Glu Leu Lys Ile Ala Tyr Lys Gln Leu Val Pro 
225                 230                 235                 240 


Pro Ser Leu Met Thr Ala His Ile Gly Glu Trp Thr Ile Thr Asp Thr 
                245                 250                 255     


Asp Glu Gly Val Leu Ala Val Ser Gln His Thr Val Thr Val Asn Glu 
            260                 265                 270         


Ala Asn Ile Thr Lys Val Leu Gly Glu Ala Gly Thr Val Ala Ser Ala 
        275                 280                 285             


Arg Asp Phe Ile Arg Arg Ala Ala Gly Gly Asn Ser Leu Ser Thr Leu 
    290                 295                 300                 


Lys His Ala Lys Ala Phe Val Glu Ala Gly 
305                 310                 


<210>  52
<211>  953
<212>  DNA
<213>  Streptomyces rimosus


<220>
<221>  CDS
<222>  (1)..(951)
<223>  oxyK (type: 2xSRPBCC) gene [GenBank ID number DQ143963.2 Position
       11443 to 12396) encoding a small molecule foldase [GenBank ID 
       number AAZ78334.2]

<400>  52
atg ccc gca ccc aca tcc cac cgc gcc gtg cac cgc acg gag atc gac         48
Met Pro Ala Pro Thr Ser His Arg Ala Val His Arg Thr Glu Ile Asp           
1               5                   10                  15                

gcc ccg gcc gac cgg gtg tac gcc ctg atc agg gac gcc gcc gag tgg         96
Ala Pro Ala Asp Arg Val Tyr Ala Leu Ile Arg Asp Ala Ala Glu Trp           
            20                  25                  30                    

ccc cgg cac ttc acc ccg acc gtc cac gtc gag cgc gcg gag ctc gac        144
Pro Arg His Phe Thr Pro Thr Val His Val Glu Arg Ala Glu Leu Asp           
        35                  40                  45                        

gcc cgc agc gag cgg ctg cgg atc tgg gcc acc gcc aac ggc gag gtc        192
Ala Arg Ser Glu Arg Leu Arg Ile Trp Ala Thr Ala Asn Gly Glu Val           
    50                  55                  60                            

aag cac tgg acg tcg cac cgc gcc ctg gac ccc gaa ggg cag agc gtc        240
Lys His Trp Thr Ser His Arg Ala Leu Asp Pro Glu Gly Gln Ser Val           
65                  70                  75                  80            

cgg ttc cgg cag gag gtg tgt tcg cct ccg gtg gcc gcg atg agc ggt        288
Arg Phe Arg Gln Glu Val Cys Ser Pro Pro Val Ala Ala Met Ser Gly           
                85                  90                  95                

gaa tgg gtc ctc cgg gac ctt ccg ggc ggg cgg tgc gag ctg acg ctg        336
Glu Trp Val Leu Arg Asp Leu Pro Gly Gly Arg Cys Glu Leu Thr Leu           
            100                 105                 110                   

cac cac acg ttc gcc gcg gtg gac gac cgc ccg gag gac gtg gag tgg        384
His His Thr Phe Ala Ala Val Asp Asp Arg Pro Glu Asp Val Glu Trp           
        115                 120                 125                       

atc acc acc gcg acc gac cgc aac agc cgt acc gag ctg gcg aac atc        432
Ile Thr Thr Ala Thr Asp Arg Asn Ser Arg Thr Glu Leu Ala Asn Ile           
    130                 135                 140                           

aag gcg ctg gcc gag gcc gcg ggg tcc gac gcg gag ctg ctg ttc tcg        480
Lys Ala Leu Ala Glu Ala Ala Gly Ser Asp Ala Glu Leu Leu Phe Ser           
145                 150                 155                 160           

ttc gag gac tcc gag acg gtg cac gcc ccg gcc gag gcg gtg tac gcg        528
Phe Glu Asp Ser Glu Thr Val His Ala Pro Ala Glu Ala Val Tyr Ala           
                165                 170                 175               

ttc ctc gcg gag gcc ggg aag tgg ccc gac cgg ctg ccg cac gtc tcc        576
Phe Leu Ala Glu Ala Gly Lys Trp Pro Asp Arg Leu Pro His Val Ser           
            180                 185                 190                   

cgg ctc gac ctc acc gag ccg tcc gac ggc gtg cag gtg atg acc atg        624
Arg Leu Asp Leu Thr Glu Pro Ser Asp Gly Val Gln Val Met Thr Met           
        195                 200                 205                       

gtc acc cgg gcc aac gac ggc tcg gag cac acg acg gag tcg gtg cgg        672
Val Thr Arg Ala Asn Asp Gly Ser Glu His Thr Thr Glu Ser Val Arg           
    210                 215                 220                           

gtc tgc ttc ccc gac gaa ctg cgc atc gtc tac aag cag atc ggc acc        720
Val Cys Phe Pro Asp Glu Leu Arg Ile Val Tyr Lys Gln Ile Gly Thr           
225                 230                 235                 240           

ccg ccg ctg atg acc ctg cac acc ggt gag tgg tcg ata cgg gac acc        768
Pro Pro Leu Met Thr Leu His Thr Gly Glu Trp Ser Ile Arg Asp Thr           
                245                 250                 255               

ggg gac ggg ctg ctc gtc acc tcc cag cac acc atc cgg atc aac gaa        816
Gly Asp Gly Leu Leu Val Thr Ser Gln His Thr Ile Arg Ile Asn Glu           
            260                 265                 270                   

tcc gcc atc ccg gag atc ctc ggc gcg gac gcc acg gcg gcc gac gcg        864
Ser Ala Ile Pro Glu Ile Leu Gly Ala Asp Ala Thr Ala Ala Asp Ala           
        275                 280                 285                       

cgg gcc cgg gtg cgc gcg gcg gtc ggc ggc aac agc gcg gcc acc ctg        912
Arg Ala Arg Val Arg Ala Ala Val Gly Gly Asn Ser Ala Ala Thr Leu           
    290                 295                 300                           

gcc ctc gcc aag cgc ttc gcg gag gcc ccg cat gcc gcc tg                 953
Ala Leu Ala Lys Arg Phe Ala Glu Ala Pro His Ala Ala                       
305                 310                 315                               


<210>  53
<211>  317
<212>  PRT
<213>  Streptomyces rimosus

<400>  53

Met Pro Ala Pro Thr Ser His Arg Ala Val His Arg Thr Glu Ile Asp 
1               5                   10                  15      


Ala Pro Ala Asp Arg Val Tyr Ala Leu Ile Arg Asp Ala Ala Glu Trp 
            20                  25                  30          


Pro Arg His Phe Thr Pro Thr Val His Val Glu Arg Ala Glu Leu Asp 
        35                  40                  45              


Ala Arg Ser Glu Arg Leu Arg Ile Trp Ala Thr Ala Asn Gly Glu Val 
    50                  55                  60                  


Lys His Trp Thr Ser His Arg Ala Leu Asp Pro Glu Gly Gln Ser Val 
65                  70                  75                  80  


Arg Phe Arg Gln Glu Val Cys Ser Pro Pro Val Ala Ala Met Ser Gly 
                85                  90                  95      


Glu Trp Val Leu Arg Asp Leu Pro Gly Gly Arg Cys Glu Leu Thr Leu 
            100                 105                 110         


His His Thr Phe Ala Ala Val Asp Asp Arg Pro Glu Asp Val Glu Trp 
        115                 120                 125             


Ile Thr Thr Ala Thr Asp Arg Asn Ser Arg Thr Glu Leu Ala Asn Ile 
    130                 135                 140                 


Lys Ala Leu Ala Glu Ala Ala Gly Ser Asp Ala Glu Leu Leu Phe Ser 
145                 150                 155                 160 


Phe Glu Asp Ser Glu Thr Val His Ala Pro Ala Glu Ala Val Tyr Ala 
                165                 170                 175     


Phe Leu Ala Glu Ala Gly Lys Trp Pro Asp Arg Leu Pro His Val Ser 
            180                 185                 190         


Arg Leu Asp Leu Thr Glu Pro Ser Asp Gly Val Gln Val Met Thr Met 
        195                 200                 205             


Val Thr Arg Ala Asn Asp Gly Ser Glu His Thr Thr Glu Ser Val Arg 
    210                 215                 220                 


Val Cys Phe Pro Asp Glu Leu Arg Ile Val Tyr Lys Gln Ile Gly Thr 
225                 230                 235                 240 


Pro Pro Leu Met Thr Leu His Thr Gly Glu Trp Ser Ile Arg Asp Thr 
                245                 250                 255     


Gly Asp Gly Leu Leu Val Thr Ser Gln His Thr Ile Arg Ile Asn Glu 
            260                 265                 270         


Ser Ala Ile Pro Glu Ile Leu Gly Ala Asp Ala Thr Ala Ala Asp Ala 
        275                 280                 285             


Arg Ala Arg Val Arg Ala Ala Val Gly Gly Asn Ser Ala Ala Thr Leu 
    290                 295                 300                 


Ala Leu Ala Lys Arg Phe Ala Glu Ala Pro His Ala Ala 
305                 310                 315         


<210>  54
<211>  950
<212>  DNA
<213>  Streptomyces coelicolor


<220>
<221>  CDS
<222>  (1)..(948)
<223>  Act_ARO-CYC_actVII (type: 2xSRPBCC) gene [GenBank ID number 
       AL939122.1 Position 162706 to 163656) encoding a first small 
       molecule foldase [GenBank ID number Q02055]

<400>  54
atg agc cgg ccg gga gaa cac cgg gtg gtc cac acc ctg agg acc cag         48
Met Ser Arg Pro Gly Glu His Arg Val Val His Thr Leu Arg Thr Gln           
1               5                   10                  15                

gcc ccg gcg cgg cgg ctc tac gag ctg gtc gca cgc gtc gaa gac tgg         96
Ala Pro Ala Arg Arg Leu Tyr Glu Leu Val Ala Arg Val Glu Asp Trp           
            20                  25                  30                    

ccg gcc gtc ttc gaa ccc acc gtg cac gta cag gtc ctg gag cgc ggc        144
Pro Ala Val Phe Glu Pro Thr Val His Val Gln Val Leu Glu Arg Gly           
        35                  40                  45                        

ccg ggc acc gaa cgc ttc cgg atc tgg gcg cgc gtg ggc ggc cgg gtg        192
Pro Gly Thr Glu Arg Phe Arg Ile Trp Ala Arg Val Gly Gly Arg Val           
    50                  55                  60                            

aag acc tgg acg tcc cgc cgg acg ctg gat ccc gac acc ctg agg gtg        240
Lys Thr Trp Thr Ser Arg Arg Thr Leu Asp Pro Asp Thr Leu Arg Val           
65                  70                  75                  80            

acg ttc cgc cag gag ctc acc cag ccg ccc atc gcc tcg atg ggc ggg        288
Thr Phe Arg Gln Glu Leu Thr Gln Pro Pro Ile Ala Ser Met Gly Gly           
                85                  90                  95                

agc tgg gag ttc cgg ggc gac ggc gac ggc acc gaa gtc gtg ctg acc        336
Ser Trp Glu Phe Arg Gly Asp Gly Asp Gly Thr Glu Val Val Leu Thr           
            100                 105                 110                   

cac gac ttc gcc gcg gtc gac gaa gcc gcc ctg ccg gga ctg cgc gag        384
His Asp Phe Ala Ala Val Asp Glu Ala Ala Leu Pro Gly Leu Arg Glu           
        115                 120                 125                       

gcg ctg gac gcg aac agc ggg aag gag ctg gcc gcg ctg gtc gcg ctg        432
Ala Leu Asp Ala Asn Ser Gly Lys Glu Leu Ala Ala Leu Val Ala Leu           
    130                 135                 140                           

gcg gag cgc cgg cag ccg ccc gag gag ctg gtc ttc acg ttc gag gac        480
Ala Glu Arg Arg Gln Pro Pro Glu Glu Leu Val Phe Thr Phe Glu Asp           
145                 150                 155                 160           

acg ctc cgg gtg ccg tcc ggg gac gac gcc tac gcc ttc atc gag cgc        528
Thr Leu Arg Val Pro Ser Gly Asp Asp Ala Tyr Ala Phe Ile Glu Arg           
                165                 170                 175               

agc gac ctg tgg cag gaa cgg ctg ccg cac gtg cgg aag gtg aca ctc        576
Ser Asp Leu Trp Gln Glu Arg Leu Pro His Val Arg Lys Val Thr Leu           
            180                 185                 190                   

acc gag gag gcg gcg ggt acc ggc ccc gcc gag acg cgg gac atg acc        624
Thr Glu Glu Ala Ala Gly Thr Gly Pro Ala Glu Thr Arg Asp Met Thr           
        195                 200                 205                       

gtc cag gac atg acc atg gag acg gtg acc acc gac ggc ggt acc cac        672
Val Gln Asp Met Thr Met Glu Thr Val Thr Thr Asp Gly Gly Thr His           
    210                 215                 220                           

acc acc cgt tcg atc cgg ctc tgc gtc ccc gcg agg agc atc gtg tac        720
Thr Thr Arg Ser Ile Arg Leu Cys Val Pro Ala Arg Ser Ile Val Tyr           
225                 230                 235                 240           

aag cag ctc gtc ccg ccc gcc ctg ctc tcc ggg cac tgc ggc gcc tgg        768
Lys Gln Leu Val Pro Pro Ala Leu Leu Ser Gly His Cys Gly Ala Trp           
                245                 250                 255               

acc ttc ggc gag gac acg gtc acc gcc cgc cac acc gtg gcg atc gac        816
Thr Phe Gly Glu Asp Thr Val Thr Ala Arg His Thr Val Ala Ile Asp           
            260                 265                 270                   

ccg gcc cgc gtg gaa gag gtc ctg ggc aaa ggc gcg acc gtc gcg gac        864
Pro Ala Arg Val Glu Glu Val Leu Gly Lys Gly Ala Thr Val Ala Asp           
        275                 280                 285                       

gcc cgt acc cat ctg cgc gag gtg ctc ggt gcc aac agc cgg gcc acg        912
Ala Arg Thr His Leu Arg Glu Val Leu Gly Ala Asn Ser Arg Ala Thr           
    290                 295                 300                           

ctc cgc cac gcg gcg gcc gcc gcc ggg ccg gcg tca tg                     950
Leu Arg His Ala Ala Ala Ala Ala Gly Pro Ala Ser                           
305                 310                 315                               


<210>  55
<211>  316
<212>  PRT
<213>  Streptomyces coelicolor

<400>  55

Met Ser Arg Pro Gly Glu His Arg Val Val His Thr Leu Arg Thr Gln 
1               5                   10                  15      


Ala Pro Ala Arg Arg Leu Tyr Glu Leu Val Ala Arg Val Glu Asp Trp 
            20                  25                  30          


Pro Ala Val Phe Glu Pro Thr Val His Val Gln Val Leu Glu Arg Gly 
        35                  40                  45              


Pro Gly Thr Glu Arg Phe Arg Ile Trp Ala Arg Val Gly Gly Arg Val 
    50                  55                  60                  


Lys Thr Trp Thr Ser Arg Arg Thr Leu Asp Pro Asp Thr Leu Arg Val 
65                  70                  75                  80  


Thr Phe Arg Gln Glu Leu Thr Gln Pro Pro Ile Ala Ser Met Gly Gly 
                85                  90                  95      


Ser Trp Glu Phe Arg Gly Asp Gly Asp Gly Thr Glu Val Val Leu Thr 
            100                 105                 110         


His Asp Phe Ala Ala Val Asp Glu Ala Ala Leu Pro Gly Leu Arg Glu 
        115                 120                 125             


Ala Leu Asp Ala Asn Ser Gly Lys Glu Leu Ala Ala Leu Val Ala Leu 
    130                 135                 140                 


Ala Glu Arg Arg Gln Pro Pro Glu Glu Leu Val Phe Thr Phe Glu Asp 
145                 150                 155                 160 


Thr Leu Arg Val Pro Ser Gly Asp Asp Ala Tyr Ala Phe Ile Glu Arg 
                165                 170                 175     


Ser Asp Leu Trp Gln Glu Arg Leu Pro His Val Arg Lys Val Thr Leu 
            180                 185                 190         


Thr Glu Glu Ala Ala Gly Thr Gly Pro Ala Glu Thr Arg Asp Met Thr 
        195                 200                 205             


Val Gln Asp Met Thr Met Glu Thr Val Thr Thr Asp Gly Gly Thr His 
    210                 215                 220                 


Thr Thr Arg Ser Ile Arg Leu Cys Val Pro Ala Arg Ser Ile Val Tyr 
225                 230                 235                 240 


Lys Gln Leu Val Pro Pro Ala Leu Leu Ser Gly His Cys Gly Ala Trp 
                245                 250                 255     


Thr Phe Gly Glu Asp Thr Val Thr Ala Arg His Thr Val Ala Ile Asp 
            260                 265                 270         


Pro Ala Arg Val Glu Glu Val Leu Gly Lys Gly Ala Thr Val Ala Asp 
        275                 280                 285             


Ala Arg Thr His Leu Arg Glu Val Leu Gly Ala Asn Ser Arg Ala Thr 
    290                 295                 300                 


Leu Arg His Ala Ala Ala Ala Ala Gly Pro Ala Ser 
305                 310                 315     


<210>  56
<211>  306
<212>  DNA
<213>  Cannabis sativa


<220>
<221>  CDS
<222>  (1)..(306)
<223>  AOC (type: DABB) gene [GenBank ID number JN679224.1 Position 
       36..341) encoding a first small molecule foldase [GenBank ID 
       number AFN42527]

<400>  56
atg gca gtg aag cat ttg att gta ttg aag ttc aaa gat gaa atc aca         48
Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr           
1               5                   10                  15                

gaa gcc caa aag gaa gaa ttt ttc aag acg tat gtg aat ctt gtg aat         96
Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn           
            20                  25                  30                    

atc atc cca gcc atg aaa gat gta tac tgg ggt aaa gat gtg act caa        144
Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln           
        35                  40                  45                        

aag aat aag gaa gaa ggg tac act cac ata gtt gag gta aca ttt gag        192
Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu           
    50                  55                  60                            

agt gtg gag act att cag gac tac att att cat cct gcc cat gtt gga        240
Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly           
65                  70                  75                  80            

ttt gga gat gtc tat cgt tct ttc tgg gaa aaa ctt ctc att ttt gac        288
Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp           
                85                  90                  95                

tac aca cca cga aag tag                                                306
Tyr Thr Pro Arg Lys                                                       
            100                                                           


<210>  57
<211>  101
<212>  PRT
<213>  Cannabis sativa

<400>  57

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210>  58
<211>  1095
<212>  DNA
<213>  Aspergillus nidulan


<220>
<221>  CDS
<222>  (1)..(1095)
<223>  wA-PT (type: PT domain) synthetic gene encoding a first small 
       molecule foldase [GenBank ID number CAA46695 position 1276 to 
       1651]

<400>  58
atg ttg act acc tct gct caa aga gtt gtc gaa tct aga gat gat ggt         48
Met Leu Thr Thr Ser Ala Gln Arg Val Val Glu Ser Arg Asp Asp Gly           
1               5                   10                  15                

ttg act gct act gtt gtt gtt cat aac gat att gcc gat cca gat ttg         96
Leu Thr Ala Thr Val Val Val His Asn Asp Ile Ala Asp Pro Asp Leu           
            20                  25                  30                    

aac aga gtt atc caa ggt cat aag gtt aat ggt gct gct ttg tgt cca        144
Asn Arg Val Ile Gln Gly His Lys Val Asn Gly Ala Ala Leu Cys Pro           
        35                  40                  45                        

tct tca tta tat gct gat tcc gct caa act ttg gcc gaa tac ttg att        192
Ser Ser Leu Tyr Ala Asp Ser Ala Gln Thr Leu Ala Glu Tyr Leu Ile           
    50                  55                  60                            

gaa aag tac aag cca gaa ttg aag ggt tct ggt ttg gat gtc tgt aat        240
Glu Lys Tyr Lys Pro Glu Leu Lys Gly Ser Gly Leu Asp Val Cys Asn           
65                  70                  75                  80            

gtt act gtt cca aag cca ttg att gcc aag act ggt aaa gaa caa ttc        288
Val Thr Val Pro Lys Pro Leu Ile Ala Lys Thr Gly Lys Glu Gln Phe           
                85                  90                  95                

aga att tct gct acc gct aac tgg gtt gat aag cac gtt tct gtt caa        336
Arg Ile Ser Ala Thr Ala Asn Trp Val Asp Lys His Val Ser Val Gln           
            100                 105                 110                   

gtt ttc tct gtt act gct gaa ggt aaa aag ttg att gat cat gct cac        384
Val Phe Ser Val Thr Ala Glu Gly Lys Lys Leu Ile Asp His Ala His           
        115                 120                 125                       

tgc gaa gtc aag ttg ttt gat tgc atg gct gct gat ttg gaa tgg aaa        432
Cys Glu Val Lys Leu Phe Asp Cys Met Ala Ala Asp Leu Glu Trp Lys           
    130                 135                 140                           

aga ggt tct tac ttg gtc aag aga tcc atc gaa tta ttg gaa aac tct        480
Arg Gly Ser Tyr Leu Val Lys Arg Ser Ile Glu Leu Leu Glu Asn Ser           
145                 150                 155                 160           

gcc gtt aag ggt gat gct cat aga ttg aga aga ggt atg gtt tac aag        528
Ala Val Lys Gly Asp Ala His Arg Leu Arg Arg Gly Met Val Tyr Lys           
                165                 170                 175               

ttg ttc tcc gct ttg gtt gat tac gac gaa aac tac caa tcc atc aga        576
Leu Phe Ser Ala Leu Val Asp Tyr Asp Glu Asn Tyr Gln Ser Ile Arg           
            180                 185                 190                   

gaa gtt atc ttg gat tcc gaa cat cat gaa gct act gct ttg gtt aag        624
Glu Val Ile Leu Asp Ser Glu His His Glu Ala Thr Ala Leu Val Lys           
        195                 200                 205                       

ttt caa gct cca caa gct aac ttc cat aga aac cca tat tgg atc gat        672
Phe Gln Ala Pro Gln Ala Asn Phe His Arg Asn Pro Tyr Trp Ile Asp           
    210                 215                 220                           

tcc ttc ggt cat ttg tct ggt ttc att atg aat gcc tct gat ggt act        720
Ser Phe Gly His Leu Ser Gly Phe Ile Met Asn Ala Ser Asp Gly Thr           
225                 230                 235                 240           

gac tcc aag tct caa gtt ttt gtt aat cac ggt tgg gac tct atg aga        768
Asp Ser Lys Ser Gln Val Phe Val Asn His Gly Trp Asp Ser Met Arg           
                245                 250                 255               

tgc ttg aaa aag ttt tct gcc gat gtt acc tac aga acc tac gtt aga        816
Cys Leu Lys Lys Phe Ser Ala Asp Val Thr Tyr Arg Thr Tyr Val Arg           
            260                 265                 270                   

atg caa cct tgg aga gat tct att tgg gct ggt aac gtt tac atc ttc        864
Met Gln Pro Trp Arg Asp Ser Ile Trp Ala Gly Asn Val Tyr Ile Phe           
        275                 280                 285                       

gaa ggt gat gat att atc gct gtt ttc ggt ggt gtc aaa ttc caa gct        912
Glu Gly Asp Asp Ile Ile Ala Val Phe Gly Gly Val Lys Phe Gln Ala           
    290                 295                 300                           

ttg tcc aga aag att ttg gat att gct ttg cca cca gcc ggt ttg tct        960
Leu Ser Arg Lys Ile Leu Asp Ile Ala Leu Pro Pro Ala Gly Leu Ser           
305                 310                 315                 320           

aaa gct caa act agt cca att caa tcc tct gct cca caa aag cca att       1008
Lys Ala Gln Thr Ser Pro Ile Gln Ser Ser Ala Pro Gln Lys Pro Ile           
                325                 330                 335               

gaa act gct aaa cct act tct aga cca gct cca cca gtt act atg aag       1056
Glu Thr Ala Lys Pro Thr Ser Arg Pro Ala Pro Pro Val Thr Met Lys           
            340                 345                 350                   

tct ttc gtt aag aaa tct gcc ggt cca tca gtt gtt gtt                   1095
Ser Phe Val Lys Lys Ser Ala Gly Pro Ser Val Val Val                       
        355                 360                 365                       


<210>  59
<211>  365
<212>  PRT
<213>  Aspergillus nidulan

<400>  59

Met Leu Thr Thr Ser Ala Gln Arg Val Val Glu Ser Arg Asp Asp Gly 
1               5                   10                  15      


Leu Thr Ala Thr Val Val Val His Asn Asp Ile Ala Asp Pro Asp Leu 
            20                  25                  30          


Asn Arg Val Ile Gln Gly His Lys Val Asn Gly Ala Ala Leu Cys Pro 
        35                  40                  45              


Ser Ser Leu Tyr Ala Asp Ser Ala Gln Thr Leu Ala Glu Tyr Leu Ile 
    50                  55                  60                  


Glu Lys Tyr Lys Pro Glu Leu Lys Gly Ser Gly Leu Asp Val Cys Asn 
65                  70                  75                  80  


Val Thr Val Pro Lys Pro Leu Ile Ala Lys Thr Gly Lys Glu Gln Phe 
                85                  90                  95      


Arg Ile Ser Ala Thr Ala Asn Trp Val Asp Lys His Val Ser Val Gln 
            100                 105                 110         


Val Phe Ser Val Thr Ala Glu Gly Lys Lys Leu Ile Asp His Ala His 
        115                 120                 125             


Cys Glu Val Lys Leu Phe Asp Cys Met Ala Ala Asp Leu Glu Trp Lys 
    130                 135                 140                 


Arg Gly Ser Tyr Leu Val Lys Arg Ser Ile Glu Leu Leu Glu Asn Ser 
145                 150                 155                 160 


Ala Val Lys Gly Asp Ala His Arg Leu Arg Arg Gly Met Val Tyr Lys 
                165                 170                 175     


Leu Phe Ser Ala Leu Val Asp Tyr Asp Glu Asn Tyr Gln Ser Ile Arg 
            180                 185                 190         


Glu Val Ile Leu Asp Ser Glu His His Glu Ala Thr Ala Leu Val Lys 
        195                 200                 205             


Phe Gln Ala Pro Gln Ala Asn Phe His Arg Asn Pro Tyr Trp Ile Asp 
    210                 215                 220                 


Ser Phe Gly His Leu Ser Gly Phe Ile Met Asn Ala Ser Asp Gly Thr 
225                 230                 235                 240 


Asp Ser Lys Ser Gln Val Phe Val Asn His Gly Trp Asp Ser Met Arg 
                245                 250                 255     


Cys Leu Lys Lys Phe Ser Ala Asp Val Thr Tyr Arg Thr Tyr Val Arg 
            260                 265                 270         


Met Gln Pro Trp Arg Asp Ser Ile Trp Ala Gly Asn Val Tyr Ile Phe 
        275                 280                 285             


Glu Gly Asp Asp Ile Ile Ala Val Phe Gly Gly Val Lys Phe Gln Ala 
    290                 295                 300                 


Leu Ser Arg Lys Ile Leu Asp Ile Ala Leu Pro Pro Ala Gly Leu Ser 
305                 310                 315                 320 


Lys Ala Gln Thr Ser Pro Ile Gln Ser Ser Ala Pro Gln Lys Pro Ile 
                325                 330                 335     


Glu Thr Ala Lys Pro Thr Ser Arg Pro Ala Pro Pro Val Thr Met Lys 
            340                 345                 350         


Ser Phe Val Lys Lys Ser Ala Gly Pro Ser Val Val Val 
        355                 360                 365 


<210>  60
<211>  1122
<212>  DNA
<213>  Fusarium fujikuroi


<220>
<221>  CDS
<222>  (1)..(1122)
<223>  BIK1-PT (type: PT domain)  synthetic gene encoding a first small 
       molecule synthase [ GenBank ID number CAB92399 Position 1252 to 
       1632]

<400>  60
atg aga ttg tcc gat tcc gtt cac aac gtt atc gaa caa gtt cat ggt         48
Met Arg Leu Ser Asp Ser Val His Asn Val Ile Glu Gln Val His Gly           
1               5                   10                  15                

gac aag aga tcc tct att acc gtt gaa tct gat atg cac gat cca tcc         96
Asp Lys Arg Ser Ser Ile Thr Val Glu Ser Asp Met His Asp Pro Ser           
            20                  25                  30                    

ttg ttg gct att gct caa aat cat aga gtt aac ggt ttg acc atg gct        144
Leu Leu Ala Ile Ala Gln Asn His Arg Val Asn Gly Leu Thr Met Ala           
        35                  40                  45                        

cca tct act ttg ttt gct gat att gct ttc act ttg gcc aag cac ttg        192
Pro Ser Thr Leu Phe Ala Asp Ile Ala Phe Thr Leu Ala Lys His Leu           
    50                  55                  60                            

att caa aat cac ggt ttg gat acc cat acc aac ttg cca tct att aac        240
Ile Gln Asn His Gly Leu Asp Thr His Thr Asn Leu Pro Ser Ile Asn           
65                  70                  75                  80            

aac atg gct gtt gaa aag gct ttg atc gtt ggt gaa act ggt cct caa        288
Asn Met Ala Val Glu Lys Ala Leu Ile Val Gly Glu Thr Gly Pro Gln           
                85                  90                  95                

tta ttc aga gct tct ttg gat atg gat tgg act act atg aga ggt tcc        336
Leu Phe Arg Ala Ser Leu Asp Met Asp Trp Thr Thr Met Arg Gly Ser           
            100                 105                 110                   

gtt aga att ttt tcc gtt ggt gct aat ggt aag caa act aca ttg cat        384
Val Arg Ile Phe Ser Val Gly Ala Asn Gly Lys Gln Thr Thr Leu His           
        115                 120                 125                       

gct gtt tgt gat gtt gcc gtt gaa aat cca tct tcc cat aga gaa tct        432
Ala Val Cys Asp Val Ala Val Glu Asn Pro Ser Ser His Arg Glu Ser           
    130                 135                 140                           

tgg caa tct aac gct tac ttg atc caa aga ggt atc aag caa ttg gtt        480
Trp Gln Ser Asn Ala Tyr Leu Ile Gln Arg Gly Ile Lys Gln Leu Val           
145                 150                 155                 160           

caa ggt gct tct gat ggt tct gct cat atg atg aga aga ggt ttg ttg        528
Gln Gly Ala Ser Asp Gly Ser Ala His Met Met Arg Arg Gly Leu Leu           
                165                 170                 175               

tac aag atc ttc tcc aac tct gtt caa tac ggt tct gct ttc caa ggt        576
Tyr Lys Ile Phe Ser Asn Ser Val Gln Tyr Gly Ser Ala Phe Gln Gly           
            180                 185                 190                   

ata gaa caa gtt tgg ttc gat tcc gaa ggt ttg gaa ggt act ggt aaa        624
Ile Glu Gln Val Trp Phe Asp Ser Glu Gly Leu Glu Gly Thr Gly Lys           
        195                 200                 205                       

gtt ttt atg cca tct ggt aag gat acc ttc gct ttg aat cca tac tgt        672
Val Phe Met Pro Ser Gly Lys Asp Thr Phe Ala Leu Asn Pro Tyr Cys           
    210                 215                 220                           

tgt gat tcc ttg ggt cat att acc ggt ttc att atg aac tgc tct gac        720
Cys Asp Ser Leu Gly His Ile Thr Gly Phe Ile Met Asn Cys Ser Asp           
225                 230                 235                 240           

tcc ttg gat ttg gat gat cat gtt tac atc aac cac ggt tgg aga act        768
Ser Leu Asp Leu Asp Asp His Val Tyr Ile Asn His Gly Trp Arg Thr           
                245                 250                 255               

ttg aga ttg gtt gaa cca tac caa tgc gac gtt caa tat caa acc tac        816
Leu Arg Leu Val Glu Pro Tyr Gln Cys Asp Val Gln Tyr Gln Thr Tyr           
            260                 265                 270                   

gtt aag atg caa gcc gtt ggt tct gat gat tct act tat tct ggt gat        864
Val Lys Met Gln Ala Val Gly Ser Asp Asp Ser Thr Tyr Ser Gly Asp           
        275                 280                 285                       

gtt cac gtc ttg aga gat ggt aag att att ggt att tgt ggt ggt gtc        912
Val His Val Leu Arg Asp Gly Lys Ile Ile Gly Ile Cys Gly Gly Val           
    290                 295                 300                           

acc ttc aag aaa gtt gct aga aaa gtc ttg gaa atg ttg ttg cca aaa        960
Thr Phe Lys Lys Val Ala Arg Lys Val Leu Glu Met Leu Leu Pro Lys           
305                 310                 315                 320           

cca tct ggt gct aaa gct aaa cat ggt gtt gtc aaa cat gtt gct cca       1008
Pro Ser Gly Ala Lys Ala Lys His Gly Val Val Lys His Val Ala Pro           
                325                 330                 335               

gaa cca gtt aag cac gtt gtt ttg act cca cca tct act act tct cat       1056
Glu Pro Val Lys His Val Val Leu Thr Pro Pro Ser Thr Thr Ser His           
            340                 345                 350                   

tct gtt ggt act aca tct cca cca gaa cct act gaa tct cca gtt ggt       1104
Ser Val Gly Thr Thr Ser Pro Pro Glu Pro Thr Glu Ser Pro Val Gly           
        355                 360                 365                       

tca gct tct ggt ttg att                                               1122
Ser Ala Ser Gly Leu Ile                                                   
    370                                                                   


<210>  61
<211>  374
<212>  PRT
<213>  Fusarium fujikuroi

<400>  61

Met Arg Leu Ser Asp Ser Val His Asn Val Ile Glu Gln Val His Gly 
1               5                   10                  15      


Asp Lys Arg Ser Ser Ile Thr Val Glu Ser Asp Met His Asp Pro Ser 
            20                  25                  30          


Leu Leu Ala Ile Ala Gln Asn His Arg Val Asn Gly Leu Thr Met Ala 
        35                  40                  45              


Pro Ser Thr Leu Phe Ala Asp Ile Ala Phe Thr Leu Ala Lys His Leu 
    50                  55                  60                  


Ile Gln Asn His Gly Leu Asp Thr His Thr Asn Leu Pro Ser Ile Asn 
65                  70                  75                  80  


Asn Met Ala Val Glu Lys Ala Leu Ile Val Gly Glu Thr Gly Pro Gln 
                85                  90                  95      


Leu Phe Arg Ala Ser Leu Asp Met Asp Trp Thr Thr Met Arg Gly Ser 
            100                 105                 110         


Val Arg Ile Phe Ser Val Gly Ala Asn Gly Lys Gln Thr Thr Leu His 
        115                 120                 125             


Ala Val Cys Asp Val Ala Val Glu Asn Pro Ser Ser His Arg Glu Ser 
    130                 135                 140                 


Trp Gln Ser Asn Ala Tyr Leu Ile Gln Arg Gly Ile Lys Gln Leu Val 
145                 150                 155                 160 


Gln Gly Ala Ser Asp Gly Ser Ala His Met Met Arg Arg Gly Leu Leu 
                165                 170                 175     


Tyr Lys Ile Phe Ser Asn Ser Val Gln Tyr Gly Ser Ala Phe Gln Gly 
            180                 185                 190         


Ile Glu Gln Val Trp Phe Asp Ser Glu Gly Leu Glu Gly Thr Gly Lys 
        195                 200                 205             


Val Phe Met Pro Ser Gly Lys Asp Thr Phe Ala Leu Asn Pro Tyr Cys 
    210                 215                 220                 


Cys Asp Ser Leu Gly His Ile Thr Gly Phe Ile Met Asn Cys Ser Asp 
225                 230                 235                 240 


Ser Leu Asp Leu Asp Asp His Val Tyr Ile Asn His Gly Trp Arg Thr 
                245                 250                 255     


Leu Arg Leu Val Glu Pro Tyr Gln Cys Asp Val Gln Tyr Gln Thr Tyr 
            260                 265                 270         


Val Lys Met Gln Ala Val Gly Ser Asp Asp Ser Thr Tyr Ser Gly Asp 
        275                 280                 285             


Val His Val Leu Arg Asp Gly Lys Ile Ile Gly Ile Cys Gly Gly Val 
    290                 295                 300                 


Thr Phe Lys Lys Val Ala Arg Lys Val Leu Glu Met Leu Leu Pro Lys 
305                 310                 315                 320 


Pro Ser Gly Ala Lys Ala Lys His Gly Val Val Lys His Val Ala Pro 
                325                 330                 335     


Glu Pro Val Lys His Val Val Leu Thr Pro Pro Ser Thr Thr Ser His 
            340                 345                 350         


Ser Val Gly Thr Thr Ser Pro Pro Glu Pro Thr Glu Ser Pro Val Gly 
        355                 360                 365             


Ser Ala Ser Gly Leu Ile 
    370                 


<210>  62
<211>  1167
<212>  DNA
<213>  Fusarium graminearum


<220>
<221>  CDS
<222>  (1)..(1167)
<223>  PGL1_PT (type: PT domain)  synthetic gene encoding a first small 
       molecule synthase [GenBank ID number EYB26831 position 1225 to 
       1613]

<400>  62
atg cca gct tat tct tgg gaa ttg aag gat tac tgg att aac acc acc         48
Met Pro Ala Tyr Ser Trp Glu Leu Lys Asp Tyr Trp Ile Asn Thr Thr           
1               5                   10                  15                

atc cac aga gtt gtt gaa gaa gaa ggt gat tcc aac aag atc cac att         96
Ile His Arg Val Val Glu Glu Glu Gly Asp Ser Asn Lys Ile His Ile           
            20                  25                  30                    

atc gtt gaa gct gat atc gcc aga aaa gac ttg tct cca ttg gtt caa        144
Ile Val Glu Ala Asp Ile Ala Arg Lys Asp Leu Ser Pro Leu Val Gln           
        35                  40                  45                        

ggt cat gaa gtt gat ggt att cca ttg tgt act cca tct gtt tac gct        192
Gly His Glu Val Asp Gly Ile Pro Leu Cys Thr Pro Ser Val Tyr Ala           
    50                  55                  60                            

gat att ggt ttg acc ttg ggt aaa tac ttg tta gaa aag tac caa cca        240
Asp Ile Gly Leu Thr Leu Gly Lys Tyr Leu Leu Glu Lys Tyr Gln Pro           
65                  70                  75                  80            

caa aac aga gac aac atg gtt gtt gtt tct gac atg act gtt tcc aag        288
Gln Asn Arg Asp Asn Met Val Val Val Ser Asp Met Thr Val Ser Lys           
                85                  90                  95                

gct ttg att ttg aga ggt gat ggt tct aag caa cct att caa gct cat        336
Ala Leu Ile Leu Arg Gly Asp Gly Ser Lys Gln Pro Ile Gln Ala His           
            100                 105                 110                   

gct gaa gca gat tgg ttg tct caa tct gtt gct atc aag ttc atg tcc        384
Ala Glu Ala Asp Trp Leu Ser Gln Ser Val Ala Ile Lys Phe Met Ser           
        115                 120                 125                       

ttc gat aac aag ggt aac ttg caa gaa cat tct gct tgc gtt gtt aga        432
Phe Asp Asn Lys Gly Asn Leu Gln Glu His Ser Ala Cys Val Val Arg           
    130                 135                 140                           

tac aag gat aga act cat caa aag acc ttg caa tcc gaa gct caa caa        480
Tyr Lys Asp Arg Thr His Gln Lys Thr Leu Gln Ser Glu Ala Gln Gln           
145                 150                 155                 160           

act aag aga aag atc caa aac ttg aga gat caa gtt acc acc gat gaa        528
Thr Lys Arg Lys Ile Gln Asn Leu Arg Asp Gln Val Thr Thr Asp Glu           
                165                 170                 175               

tcc gct aga ttc aat aga cca atg gtt tac aga atg atc aga cca ttg        576
Ser Ala Arg Phe Asn Arg Pro Met Val Tyr Arg Met Ile Arg Pro Leu           
            180                 185                 190                   

gct aga ttc cac gat gat tac aga gct atc gat gaa gtt gtc ttg aac        624
Ala Arg Phe His Asp Asp Tyr Arg Ala Ile Asp Glu Val Val Leu Asn           
        195                 200                 205                       

tct gaa act ttg gaa gcc tcc tct aag att tct ttc ggt act gtt aag        672
Ser Glu Thr Leu Glu Ala Ser Ser Lys Ile Ser Phe Gly Thr Val Lys           
    210                 215                 220                           

aga gaa ggt gac tat cat act cat cca gcc gtt att gat tct ttg act        720
Arg Glu Gly Asp Tyr His Thr His Pro Ala Val Ile Asp Ser Leu Thr           
225                 230                 235                 240           

caa tct tgt ggt ttc gcc atg aac tgt aac gat cat acc gat att gat        768
Gln Ser Cys Gly Phe Ala Met Asn Cys Asn Asp His Thr Asp Ile Asp           
                245                 250                 255               

gtc gac gtt tac atg aat cat ggt tgg ggt tct ttg gaa tta ttc gaa        816
Val Asp Val Tyr Met Asn His Gly Trp Gly Ser Leu Glu Leu Phe Glu           
            260                 265                 270                   

gct ttg gac ttc gaa aaa gaa tac act acc tac acc caa atg cat gct        864
Ala Leu Asp Phe Glu Lys Glu Tyr Thr Thr Tyr Thr Gln Met His Ala           
        275                 280                 285                       

ggt gaa gat aag ttg tgg tac ggt gat gtt act gtt ttc gat ggt gat        912
Gly Glu Asp Lys Leu Trp Tyr Gly Asp Val Thr Val Phe Asp Gly Asp           
    290                 295                 300                           

aga gtt gtc gct ttc ttt ggt caa att gcc att caa ggt gtt cct aga        960
Arg Val Val Ala Phe Phe Gly Gln Ile Ala Ile Gln Gly Val Pro Arg           
305                 310                 315                 320           

aga gtt ttg aag gtc atc ttg tcc att gaa tct ggt aaa aag ggt caa       1008
Arg Val Leu Lys Val Ile Leu Ser Ile Glu Ser Gly Lys Lys Gly Gln           
                325                 330                 335               

cct caa aga cca gtt caa gat aag cca caa act act tct aaa cca tct       1056
Pro Gln Arg Pro Val Gln Asp Lys Pro Gln Thr Thr Ser Lys Pro Ser           
            340                 345                 350                   

gct aca cca tct cca aaa cct act caa aac aaa cca gct gct aaa atg       1104
Ala Thr Pro Ser Pro Lys Pro Thr Gln Asn Lys Pro Ala Ala Lys Met           
        355                 360                 365                       

gaa cct act aag ttc tct acc gcc ttg aga att atc tct gaa gaa tcc       1152
Glu Pro Thr Lys Phe Ser Thr Ala Leu Arg Ile Ile Ser Glu Glu Ser           
    370                 375                 380                           

ggt atc gaa att agt                                                   1167
Gly Ile Glu Ile Ser                                                       
385                                                                       


<210>  63
<211>  389
<212>  PRT
<213>  Fusarium graminearum

<400>  63

Met Pro Ala Tyr Ser Trp Glu Leu Lys Asp Tyr Trp Ile Asn Thr Thr 
1               5                   10                  15      


Ile His Arg Val Val Glu Glu Glu Gly Asp Ser Asn Lys Ile His Ile 
            20                  25                  30          


Ile Val Glu Ala Asp Ile Ala Arg Lys Asp Leu Ser Pro Leu Val Gln 
        35                  40                  45              


Gly His Glu Val Asp Gly Ile Pro Leu Cys Thr Pro Ser Val Tyr Ala 
    50                  55                  60                  


Asp Ile Gly Leu Thr Leu Gly Lys Tyr Leu Leu Glu Lys Tyr Gln Pro 
65                  70                  75                  80  


Gln Asn Arg Asp Asn Met Val Val Val Ser Asp Met Thr Val Ser Lys 
                85                  90                  95      


Ala Leu Ile Leu Arg Gly Asp Gly Ser Lys Gln Pro Ile Gln Ala His 
            100                 105                 110         


Ala Glu Ala Asp Trp Leu Ser Gln Ser Val Ala Ile Lys Phe Met Ser 
        115                 120                 125             


Phe Asp Asn Lys Gly Asn Leu Gln Glu His Ser Ala Cys Val Val Arg 
    130                 135                 140                 


Tyr Lys Asp Arg Thr His Gln Lys Thr Leu Gln Ser Glu Ala Gln Gln 
145                 150                 155                 160 


Thr Lys Arg Lys Ile Gln Asn Leu Arg Asp Gln Val Thr Thr Asp Glu 
                165                 170                 175     


Ser Ala Arg Phe Asn Arg Pro Met Val Tyr Arg Met Ile Arg Pro Leu 
            180                 185                 190         


Ala Arg Phe His Asp Asp Tyr Arg Ala Ile Asp Glu Val Val Leu Asn 
        195                 200                 205             


Ser Glu Thr Leu Glu Ala Ser Ser Lys Ile Ser Phe Gly Thr Val Lys 
    210                 215                 220                 


Arg Glu Gly Asp Tyr His Thr His Pro Ala Val Ile Asp Ser Leu Thr 
225                 230                 235                 240 


Gln Ser Cys Gly Phe Ala Met Asn Cys Asn Asp His Thr Asp Ile Asp 
                245                 250                 255     


Val Asp Val Tyr Met Asn His Gly Trp Gly Ser Leu Glu Leu Phe Glu 
            260                 265                 270         


Ala Leu Asp Phe Glu Lys Glu Tyr Thr Thr Tyr Thr Gln Met His Ala 
        275                 280                 285             


Gly Glu Asp Lys Leu Trp Tyr Gly Asp Val Thr Val Phe Asp Gly Asp 
    290                 295                 300                 


Arg Val Val Ala Phe Phe Gly Gln Ile Ala Ile Gln Gly Val Pro Arg 
305                 310                 315                 320 


Arg Val Leu Lys Val Ile Leu Ser Ile Glu Ser Gly Lys Lys Gly Gln 
                325                 330                 335     


Pro Gln Arg Pro Val Gln Asp Lys Pro Gln Thr Thr Ser Lys Pro Ser 
            340                 345                 350         


Ala Thr Pro Ser Pro Lys Pro Thr Gln Asn Lys Pro Ala Ala Lys Met 
        355                 360                 365             


Glu Pro Thr Lys Phe Ser Thr Ala Leu Arg Ile Ile Ser Glu Glu Ser 
    370                 375                 380                 


Gly Ile Glu Ile Ser 
385                 


<210>  64
<211>  1215
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(1215)
<223>  mpdG_PT (type: PT domain) synthetic gene encoding a first small 
       molecule foldase [GenBank ID number XP_657754.1 position 1335 to 
       1739]

<400>  64
atg tct ggt ttg aga act tcc acc gtt caa caa atc atc gaa gaa tct         48
Met Ser Gly Leu Arg Thr Ser Thr Val Gln Gln Ile Ile Glu Glu Ser           
1               5                   10                  15                

ttt aac ggt tcc gct ggt aag gtt gtt atg caa tct gat atg atg caa         96
Phe Asn Gly Ser Ala Gly Lys Val Val Met Gln Ser Asp Met Met Gln           
            20                  25                  30                    

cca gat ttc ttg gat gct gct cat ggt cat aag atg aat ggt tgt ggt        144
Pro Asp Phe Leu Asp Ala Ala His Gly His Lys Met Asn Gly Cys Gly           
        35                  40                  45                        

gtt gtt acc tcc tct att cat ggt gat att ggt ttt act ttg ggt ggt        192
Val Val Thr Ser Ser Ile His Gly Asp Ile Gly Phe Thr Leu Gly Gly           
    50                  55                  60                            

tac ttg tac aaa aac ttg gtt aag ggt ggt aag gct cca gat atg aat        240
Tyr Leu Tyr Lys Asn Leu Val Lys Gly Gly Lys Ala Pro Asp Met Asn           
65                  70                  75                  80            

atg gct aat ttg gtt gtc ttg aga ggt ttg gtt gct caa aag aac act        288
Met Ala Asn Leu Val Val Leu Arg Gly Leu Val Ala Gln Lys Asn Thr           
                85                  90                  95                

aag aag cca caa tat atc aga gtc acc att tct acc acc gat atc aat        336
Lys Lys Pro Gln Tyr Ile Arg Val Thr Ile Ser Thr Thr Asp Ile Asn           
            100                 105                 110                   

tct ggt gtt gcc gaa ttg att tgg caa aac gtc ttg aat gat aac acc        384
Ser Gly Val Ala Glu Leu Ile Trp Gln Asn Val Leu Asn Asp Asn Thr           
        115                 120                 125                       

gct gat gaa cca ttt gct tca gct tct atc ttg tat gat gat gct gct        432
Ala Asp Glu Pro Phe Ala Ser Ala Ser Ile Leu Tyr Asp Asp Ala Ala           
    130                 135                 140                           

ttg tgg ttg aag tct tgg att cca tct act cat ttg gtc caa ggt aga        480
Leu Trp Leu Lys Ser Trp Ile Pro Ser Thr His Leu Val Gln Gly Arg           
145                 150                 155                 160           

att gaa gcc ttg gaa aga ttg gct gaa gat ggt att gct aac aga ttc        528
Ile Glu Ala Leu Glu Arg Leu Ala Glu Asp Gly Ile Ala Asn Arg Phe           
                165                 170                 175               

act aga aac atg gcc tac ttg ttg ttc gct aac aac ttg gtt gat tac        576
Thr Arg Asn Met Ala Tyr Leu Leu Phe Ala Asn Asn Leu Val Asp Tyr           
            180                 185                 190                   

gcc caa aag tat aga ggt atg caa tca gtt gtc ttg cat gaa ttg gaa        624
Ala Gln Lys Tyr Arg Gly Met Gln Ser Val Val Leu His Glu Leu Glu           
        195                 200                 205                       

gct ttc gct gat att acc ttg tct act gaa aaa tct ggt act tgg act        672
Ala Phe Ala Asp Ile Thr Leu Ser Thr Glu Lys Ser Gly Thr Trp Thr           
    210                 215                 220                           

atc cca cca tac ttc att gat tct gtt gct cat ttg gct ggt ttc gtc        720
Ile Pro Pro Tyr Phe Ile Asp Ser Val Ala His Leu Ala Gly Phe Val           
225                 230                 235                 240           

atg aat gtt tct gat gct att gat acc aag gcc aac tat tgt gtt act        768
Met Asn Val Ser Asp Ala Ile Asp Thr Lys Ala Asn Tyr Cys Val Thr           
                245                 250                 255               

cca ggt tgg aag tct ttg aga ttt gct aaa cca ttg gtt gct ggt gct        816
Pro Gly Trp Lys Ser Leu Arg Phe Ala Lys Pro Leu Val Ala Gly Ala           
            260                 265                 270                   

aag tat aga tcc tac gtt aag atg atc caa acc gaa gaa gat cca act        864
Lys Tyr Arg Ser Tyr Val Lys Met Ile Gln Thr Glu Glu Asp Pro Thr           
        275                 280                 285                       

gtt tat ttg ggt gat gtc tac att atg caa gat ggt gcc att att ggt        912
Val Tyr Leu Gly Asp Val Tyr Ile Met Gln Asp Gly Ala Ile Ile Gly           
    290                 295                 300                           

atg tgc ggt ggt att caa ttc aga aga tac cca aga atc ttg ttg aat        960
Met Cys Gly Gly Ile Gln Phe Arg Arg Tyr Pro Arg Ile Leu Leu Asn           
305                 310                 315                 320           

aga ttc ttc acc gct cct gaa gaa gct ggt gca att tct cat gct gct       1008
Arg Phe Phe Thr Ala Pro Glu Glu Ala Gly Ala Ile Ser His Ala Ala           
                325                 330                 335               

gct tca tct act cca gct cca aga aca aaa cca gaa cca gtt cca gtt       1056
Ala Ser Ser Thr Pro Ala Pro Arg Thr Lys Pro Glu Pro Val Pro Val           
            340                 345                 350                   

gct aca cca gct aca gct gct gct cca gtt gca caa tct cca gca gct       1104
Ala Thr Pro Ala Thr Ala Ala Ala Pro Val Ala Gln Ser Pro Ala Ala           
        355                 360                 365                       

cca gct tct gtt act cct gct cca gca cca gcc cca gct cca ggt cca       1152
Pro Ala Ser Val Thr Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Pro           
    370                 375                 380                           

act cct gct gct gcc cca gct gcc gct ggt gaa tct gat tca gtt gct       1200
Thr Pro Ala Ala Ala Pro Ala Ala Ala Gly Glu Ser Asp Ser Val Ala           
385                 390                 395                 400           

gct aaa gct ttg gtc                                                   1215
Ala Lys Ala Leu Val                                                       
                405                                                       


<210>  65
<211>  405
<212>  PRT
<213>  Aspergillus nidulans

<400>  65

Met Ser Gly Leu Arg Thr Ser Thr Val Gln Gln Ile Ile Glu Glu Ser 
1               5                   10                  15      


Phe Asn Gly Ser Ala Gly Lys Val Val Met Gln Ser Asp Met Met Gln 
            20                  25                  30          


Pro Asp Phe Leu Asp Ala Ala His Gly His Lys Met Asn Gly Cys Gly 
        35                  40                  45              


Val Val Thr Ser Ser Ile His Gly Asp Ile Gly Phe Thr Leu Gly Gly 
    50                  55                  60                  


Tyr Leu Tyr Lys Asn Leu Val Lys Gly Gly Lys Ala Pro Asp Met Asn 
65                  70                  75                  80  


Met Ala Asn Leu Val Val Leu Arg Gly Leu Val Ala Gln Lys Asn Thr 
                85                  90                  95      


Lys Lys Pro Gln Tyr Ile Arg Val Thr Ile Ser Thr Thr Asp Ile Asn 
            100                 105                 110         


Ser Gly Val Ala Glu Leu Ile Trp Gln Asn Val Leu Asn Asp Asn Thr 
        115                 120                 125             


Ala Asp Glu Pro Phe Ala Ser Ala Ser Ile Leu Tyr Asp Asp Ala Ala 
    130                 135                 140                 


Leu Trp Leu Lys Ser Trp Ile Pro Ser Thr His Leu Val Gln Gly Arg 
145                 150                 155                 160 


Ile Glu Ala Leu Glu Arg Leu Ala Glu Asp Gly Ile Ala Asn Arg Phe 
                165                 170                 175     


Thr Arg Asn Met Ala Tyr Leu Leu Phe Ala Asn Asn Leu Val Asp Tyr 
            180                 185                 190         


Ala Gln Lys Tyr Arg Gly Met Gln Ser Val Val Leu His Glu Leu Glu 
        195                 200                 205             


Ala Phe Ala Asp Ile Thr Leu Ser Thr Glu Lys Ser Gly Thr Trp Thr 
    210                 215                 220                 


Ile Pro Pro Tyr Phe Ile Asp Ser Val Ala His Leu Ala Gly Phe Val 
225                 230                 235                 240 


Met Asn Val Ser Asp Ala Ile Asp Thr Lys Ala Asn Tyr Cys Val Thr 
                245                 250                 255     


Pro Gly Trp Lys Ser Leu Arg Phe Ala Lys Pro Leu Val Ala Gly Ala 
            260                 265                 270         


Lys Tyr Arg Ser Tyr Val Lys Met Ile Gln Thr Glu Glu Asp Pro Thr 
        275                 280                 285             


Val Tyr Leu Gly Asp Val Tyr Ile Met Gln Asp Gly Ala Ile Ile Gly 
    290                 295                 300                 


Met Cys Gly Gly Ile Gln Phe Arg Arg Tyr Pro Arg Ile Leu Leu Asn 
305                 310                 315                 320 


Arg Phe Phe Thr Ala Pro Glu Glu Ala Gly Ala Ile Ser His Ala Ala 
                325                 330                 335     


Ala Ser Ser Thr Pro Ala Pro Arg Thr Lys Pro Glu Pro Val Pro Val 
            340                 345                 350         


Ala Thr Pro Ala Thr Ala Ala Ala Pro Val Ala Gln Ser Pro Ala Ala 
        355                 360                 365             


Pro Ala Ser Val Thr Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Pro 
    370                 375                 380                 


Thr Pro Ala Ala Ala Pro Ala Ala Ala Gly Glu Ser Asp Ser Val Ala 
385                 390                 395                 400 


Ala Lys Ala Leu Val 
                405 


<210>  66
<211>  720
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(720)
<223>  ZhuI-1 (type: SRPBCC) gene [GenBank ID number ANIA_10642) 
       encoding a first small molecule foldase [GenBank ID number 
       CBF80957]

<400>  66
atg aac cac ctg ctt gca cca cgg tct att ttc tac cta aat tca aaa         48
Met Asn His Leu Leu Ala Pro Arg Ser Ile Phe Tyr Leu Asn Ser Lys           
1               5                   10                  15                

gtg cct acg ata cgg cca gaa atc tta cga tgt cgc ctc ttt tgc tac         96
Val Pro Thr Ile Arg Pro Glu Ile Leu Arg Cys Arg Leu Phe Cys Tyr           
            20                  25                  30                    

acc tcc agg ctt caa ggg tta ccg caa caa ccc tct tat aga caa agt        144
Thr Ser Arg Leu Gln Gly Leu Pro Gln Gln Pro Ser Tyr Arg Gln Ser           
        35                  40                  45                        

tat aac cct caa ttt cag tct cga att gaa aaa cga act ttt ttg tcg        192
Tyr Asn Pro Gln Phe Gln Ser Arg Ile Glu Lys Arg Thr Phe Leu Ser           
    50                  55                  60                            

tca ttt atc cct tct ccg ccc caa gct tct aac aat ggg gac gga aat        240
Ser Phe Ile Pro Ser Pro Pro Gln Ala Ser Asn Asn Gly Asp Gly Asn           
65                  70                  75                  80            

ggc aac aac aaa gcc cgc atc ctg aca gcc tcc cgc aca ctt ccc tac        288
Gly Asn Asn Lys Ala Arg Ile Leu Thr Ala Ser Arg Thr Leu Pro Tyr           
                85                  90                  95                

ccg cca tcc ccc tta ttc aac gta ata tcc tcc gtt gaa tcc tac gcc        336
Pro Pro Ser Pro Leu Phe Asn Val Ile Ser Ser Val Glu Ser Tyr Ala           
            100                 105                 110                   

gag ttc ctc ccc ttc ctc acc gcg tcc act gtt acg gcc cgt gac ccc        384
Glu Phe Leu Pro Phe Leu Thr Ala Ser Thr Val Thr Ala Arg Asp Pro           
        115                 120                 125                       

gag aca cgg tat ccg acg cag gcg tat ctc aca gtc gga tat ggg cct        432
Glu Thr Arg Tyr Pro Thr Gln Ala Tyr Leu Thr Val Gly Tyr Gly Pro           
    130                 135                 140                           

ctt agc gag acg ttt acg tcg aag gtt gac tgt aat cgg gag agt tgg        480
Leu Ser Glu Thr Phe Thr Ser Lys Val Asp Cys Asn Arg Glu Ser Trp           
145                 150                 155                 160           

gtt gtt gag gcg cgg agc ggg gaa agg ttt ggg atc ttc gag tat ctg        528
Val Val Glu Ala Arg Ser Gly Glu Arg Phe Gly Ile Phe Glu Tyr Leu           
                165                 170                 175               

agc acg agg tgg gag ttg gtt ccg gag act gct tct gag ggg gga gac        576
Ser Thr Arg Trp Glu Leu Val Pro Glu Thr Ala Ser Glu Gly Gly Asp           
            180                 185                 190                   

gcg agg acc acg gtt aat ctg gag atc cgg ttt gag ttt aag agt cag        624
Ala Arg Thr Thr Val Asn Leu Glu Ile Arg Phe Glu Phe Lys Ser Gln           
        195                 200                 205                       

ttg tat gcg agt atg atg agt gca gtg gaa ggg cag atg gcg ggg att        672
Leu Tyr Ala Ser Met Met Ser Ala Val Glu Gly Gln Met Ala Gly Ile           
    210                 215                 220                           

atg atc gag gca ttc gaa aag agg att aga gaa gtg cat ggg agg tga        720
Met Ile Glu Ala Phe Glu Lys Arg Ile Arg Glu Val His Gly Arg               
225                 230                 235                               


<210>  67
<211>  239
<212>  PRT
<213>  Aspergillus nidulans

<400>  67

Met Asn His Leu Leu Ala Pro Arg Ser Ile Phe Tyr Leu Asn Ser Lys 
1               5                   10                  15      


Val Pro Thr Ile Arg Pro Glu Ile Leu Arg Cys Arg Leu Phe Cys Tyr 
            20                  25                  30          


Thr Ser Arg Leu Gln Gly Leu Pro Gln Gln Pro Ser Tyr Arg Gln Ser 
        35                  40                  45              


Tyr Asn Pro Gln Phe Gln Ser Arg Ile Glu Lys Arg Thr Phe Leu Ser 
    50                  55                  60                  


Ser Phe Ile Pro Ser Pro Pro Gln Ala Ser Asn Asn Gly Asp Gly Asn 
65                  70                  75                  80  


Gly Asn Asn Lys Ala Arg Ile Leu Thr Ala Ser Arg Thr Leu Pro Tyr 
                85                  90                  95      


Pro Pro Ser Pro Leu Phe Asn Val Ile Ser Ser Val Glu Ser Tyr Ala 
            100                 105                 110         


Glu Phe Leu Pro Phe Leu Thr Ala Ser Thr Val Thr Ala Arg Asp Pro 
        115                 120                 125             


Glu Thr Arg Tyr Pro Thr Gln Ala Tyr Leu Thr Val Gly Tyr Gly Pro 
    130                 135                 140                 


Leu Ser Glu Thr Phe Thr Ser Lys Val Asp Cys Asn Arg Glu Ser Trp 
145                 150                 155                 160 


Val Val Glu Ala Arg Ser Gly Glu Arg Phe Gly Ile Phe Glu Tyr Leu 
                165                 170                 175     


Ser Thr Arg Trp Glu Leu Val Pro Glu Thr Ala Ser Glu Gly Gly Asp 
            180                 185                 190         


Ala Arg Thr Thr Val Asn Leu Glu Ile Arg Phe Glu Phe Lys Ser Gln 
        195                 200                 205             


Leu Tyr Ala Ser Met Met Ser Ala Val Glu Gly Gln Met Ala Gly Ile 
    210                 215                 220                 


Met Ile Glu Ala Phe Glu Lys Arg Ile Arg Glu Val His Gly Arg 
225                 230                 235                 


<210>  68
<211>  621
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(621)
<223>  ZhuI-2 (type: SRPBCC) gene [GenBank ID number AN3000.2) encoding 
       a first small molecule foldase [GenBank ID number XP_660604.1]

<400>  68
atg tcg tct ctc aac cat ccc gat acc ccg aac att ccc tct tcc tcc         48
Met Ser Ser Leu Asn His Pro Asp Thr Pro Asn Ile Pro Ser Ser Ser           
1               5                   10                  15                

gcc atc ctc ggc atc cag agc tcc act ctc att gat gcc ccc atc caa         96
Ala Ile Leu Gly Ile Gln Ser Ser Thr Leu Ile Asp Ala Pro Ile Gln           
            20                  25                  30                    

gtc gtc tgg agc gct ctt aca gac aca tct acc tac ccg aga tgg aac        144
Val Val Trp Ser Ala Leu Thr Asp Thr Ser Thr Tyr Pro Arg Trp Asn           
        35                  40                  45                        

cga ttt gta ccg cgg gtg acc gtt cgc gag cag cct gac tca ggc aac        192
Arg Phe Val Pro Arg Val Thr Val Arg Glu Gln Pro Asp Ser Gly Asn           
    50                  55                  60                            

gag gat gca atc ctg aga aac gga aca aga ttc acg ttc cac gtc aac        240
Glu Asp Ala Ile Leu Arg Asn Gly Thr Arg Phe Thr Phe His Val Asn           
65                  70                  75                  80            

atg tac ccc gaa gca gat gac gaa ccg cag ccg caa aat aaa aat ctc        288
Met Tyr Pro Glu Ala Asp Asp Glu Pro Gln Pro Gln Asn Lys Asn Leu           
                85                  90                  95                

cgc gac acg ttc ctg aaa att ata gag gtc gag ccg ccg gcg tca aca        336
Arg Asp Thr Phe Leu Lys Ile Ile Glu Val Glu Pro Pro Ala Ser Thr           
            100                 105                 110                   

gaa ccc gct gat agt ggc ttg agg aaa ggc aaa att gta tgg gcg tcg        384
Glu Pro Ala Asp Ser Gly Leu Arg Lys Gly Lys Ile Val Trp Ala Ser           
        115                 120                 125                       

gac ccc gct gca gac gga tat gtc ata tct tca ttg ttg acc gcc gag        432
Asp Pro Ala Ala Asp Gly Tyr Val Ile Ser Ser Leu Leu Thr Ala Glu           
    130                 135                 140                           

cgc gtc cat gag ctg gaa gag gtg ata gac ggc aat ggg aag aga atg        480
Arg Val His Glu Leu Glu Glu Val Ile Asp Gly Asn Gly Lys Arg Met           
145                 150                 155                 160           

aca atg gtg aca aat tgg gaa tcg cag gtg ggt ggt ctg gct tat gtg        528
Thr Met Val Thr Asn Trp Glu Ser Gln Val Gly Gly Leu Ala Tyr Val           
                165                 170                 175               

gtg aaa tgg atg ttt ggg ggc agg tta aaa ggg aat ttc aca att tgg        576
Val Lys Trp Met Phe Gly Gly Arg Leu Lys Gly Asn Phe Thr Ile Trp           
            180                 185                 190                   

gag aat ggc ctg aag gaa tac gcc gaa cgg aac tgg gag aat tag            621
Glu Asn Gly Leu Lys Glu Tyr Ala Glu Arg Asn Trp Glu Asn                   
        195                 200                 205                       


<210>  69
<211>  206
<212>  PRT
<213>  Aspergillus nidulans

<400>  69

Met Ser Ser Leu Asn His Pro Asp Thr Pro Asn Ile Pro Ser Ser Ser 
1               5                   10                  15      


Ala Ile Leu Gly Ile Gln Ser Ser Thr Leu Ile Asp Ala Pro Ile Gln 
            20                  25                  30          


Val Val Trp Ser Ala Leu Thr Asp Thr Ser Thr Tyr Pro Arg Trp Asn 
        35                  40                  45              


Arg Phe Val Pro Arg Val Thr Val Arg Glu Gln Pro Asp Ser Gly Asn 
    50                  55                  60                  


Glu Asp Ala Ile Leu Arg Asn Gly Thr Arg Phe Thr Phe His Val Asn 
65                  70                  75                  80  


Met Tyr Pro Glu Ala Asp Asp Glu Pro Gln Pro Gln Asn Lys Asn Leu 
                85                  90                  95      


Arg Asp Thr Phe Leu Lys Ile Ile Glu Val Glu Pro Pro Ala Ser Thr 
            100                 105                 110         


Glu Pro Ala Asp Ser Gly Leu Arg Lys Gly Lys Ile Val Trp Ala Ser 
        115                 120                 125             


Asp Pro Ala Ala Asp Gly Tyr Val Ile Ser Ser Leu Leu Thr Ala Glu 
    130                 135                 140                 


Arg Val His Glu Leu Glu Glu Val Ile Asp Gly Asn Gly Lys Arg Met 
145                 150                 155                 160 


Thr Met Val Thr Asn Trp Glu Ser Gln Val Gly Gly Leu Ala Tyr Val 
                165                 170                 175     


Val Lys Trp Met Phe Gly Gly Arg Leu Lys Gly Asn Phe Thr Ile Trp 
            180                 185                 190         


Glu Asn Gly Leu Lys Glu Tyr Ala Glu Arg Asn Trp Glu Asn 
        195                 200                 205     


<210>  70
<211>  336
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(336)
<223>  AOC-1 (type: Dabb) gene [GenBank ID number AN8584.2) encoding a 
       first small molecule synthase [GenBank ID number XP_681853.1]

<400>  70
atg tct gtg aca cat atc gtt gtc ttc cgc ttc aag gat gga acg agt         48
Met Ser Val Thr His Ile Val Val Phe Arg Phe Lys Asp Gly Thr Ser           
1               5                   10                  15                

gac gag aag atc gaa gag gtg tgc cgt gag gtt gta gcc ctc aag gag         96
Asp Glu Lys Ile Glu Glu Val Cys Arg Glu Val Val Ala Leu Lys Glu           
            20                  25                  30                    

aag tgc att ttg cca cgg acc cag aag ccc tac att aaa tcc tac gtt        144
Lys Cys Ile Leu Pro Arg Thr Gln Lys Pro Tyr Ile Lys Ser Tyr Val           
        35                  40                  45                        

ggt ggc aaa gac cac tcc cct gaa ggc gcc cag cat ggg atg acg cat        192
Gly Gly Lys Asp His Ser Pro Glu Gly Ala Gln His Gly Met Thr His           
    50                  55                  60                            

gcg ttt gtg gcc cag ttc gag agc cga gag gat cgc gac tac tac gtc        240
Ala Phe Val Ala Gln Phe Glu Ser Arg Glu Asp Arg Asp Tyr Tyr Val           
65                  70                  75                  80            

tcc aag gat ccc gtc cac ctg gaa ctt gga ccc cga att gcg ccg gtg        288
Ser Lys Asp Pro Val His Leu Glu Leu Gly Pro Arg Ile Ala Pro Val           
                85                  90                  95                

gtc gag aca ttt ctg tgc cta gac ttc act cct ggg ctc att ctg tga        336
Val Glu Thr Phe Leu Cys Leu Asp Phe Thr Pro Gly Leu Ile Leu               
            100                 105                 110                   


<210>  71
<211>  111
<212>  PRT
<213>  Aspergillus nidulans

<400>  71

Met Ser Val Thr His Ile Val Val Phe Arg Phe Lys Asp Gly Thr Ser 
1               5                   10                  15      


Asp Glu Lys Ile Glu Glu Val Cys Arg Glu Val Val Ala Leu Lys Glu 
            20                  25                  30          


Lys Cys Ile Leu Pro Arg Thr Gln Lys Pro Tyr Ile Lys Ser Tyr Val 
        35                  40                  45              


Gly Gly Lys Asp His Ser Pro Glu Gly Ala Gln His Gly Met Thr His 
    50                  55                  60                  


Ala Phe Val Ala Gln Phe Glu Ser Arg Glu Asp Arg Asp Tyr Tyr Val 
65                  70                  75                  80  


Ser Lys Asp Pro Val His Leu Glu Leu Gly Pro Arg Ile Ala Pro Val 
                85                  90                  95      


Val Glu Thr Phe Leu Cys Leu Asp Phe Thr Pro Gly Leu Ile Leu 
            100                 105                 110     


<210>  72
<211>  333
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(333)
<223>  AOC-2 (type: Dabb) gene [GenBank ID number ANIA_01204) encoding a
       first small molecule foldase [GenBank ID number CBF87939.1]

<400>  72
atg ccc atc acg cac att gtt atg ttc caa gtc aag cag ggc ctc agc         48
Met Pro Ile Thr His Ile Val Met Phe Gln Val Lys Gln Gly Leu Ser           
1               5                   10                  15                

gcc gaa acc gtc aac gac ctg tgt ttg cgg atg ctg tcc ctc aaa gac         96
Ala Glu Thr Val Asn Asp Leu Cys Leu Arg Met Leu Ser Leu Lys Asp           
            20                  25                  30                    

aaa tgc atc cac cct gtt tcc cag aag ccg tat att att tcc tca tcc        144
Lys Cys Ile His Pro Val Ser Gln Lys Pro Tyr Ile Ile Ser Ser Ser           
        35                  40                  45                        

ggt ggc ata gat aac tcc ccc gaa ggg atg cag aac ggt atc acg cac        192
Gly Gly Ile Asp Asn Ser Pro Glu Gly Met Gln Asn Gly Ile Thr His           
    50                  55                  60                            

gct ttt gtg gtt gag ttc gcc aat gaa gag gac agg gct tat tat ctc        240
Ala Phe Val Val Glu Phe Ala Asn Glu Glu Asp Arg Ala Tyr Tyr Leu           
65                  70                  75                  80            

gag aag gac cct gcg cat ctg gaa ttt gtg ggc agt ttg aag gac gta        288
Glu Lys Asp Pro Ala His Leu Glu Phe Val Gly Ser Leu Lys Asp Val           
                85                  90                  95                

att gag aag gcg cag gtc gtc gac ttc acc aac ggt gtg ttt tga            333
Ile Glu Lys Ala Gln Val Val Asp Phe Thr Asn Gly Val Phe                   
            100                 105                 110                   


<210>  73
<211>  110
<212>  PRT
<213>  Aspergillus nidulans

<400>  73

Met Pro Ile Thr His Ile Val Met Phe Gln Val Lys Gln Gly Leu Ser 
1               5                   10                  15      


Ala Glu Thr Val Asn Asp Leu Cys Leu Arg Met Leu Ser Leu Lys Asp 
            20                  25                  30          


Lys Cys Ile His Pro Val Ser Gln Lys Pro Tyr Ile Ile Ser Ser Ser 
        35                  40                  45              


Gly Gly Ile Asp Asn Ser Pro Glu Gly Met Gln Asn Gly Ile Thr His 
    50                  55                  60                  


Ala Phe Val Val Glu Phe Ala Asn Glu Glu Asp Arg Ala Tyr Tyr Leu 
65                  70                  75                  80  


Glu Lys Asp Pro Ala His Leu Glu Phe Val Gly Ser Leu Lys Asp Val 
                85                  90                  95      


Ile Glu Lys Ala Gln Val Val Asp Phe Thr Asn Gly Val Phe 
            100                 105                 110 


<210>  74
<211>  486
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(486)
<223>  AOC-3 (type: Dabb) gene [GenBank ID number ANIA_10997) encodign a
       first small molecule synthase [GenBank ID number CBF79774.1]

<400>  74
atg ctg aac gat gat gca gtg ctt ttc aaa ttc cgc tcc ggt gtc act         48
Met Leu Asn Asp Asp Ala Val Leu Phe Lys Phe Arg Ser Gly Val Thr           
1               5                   10                  15                

tta gag cag aag aac aag ttt att cga gag ctc aag aca ctg aag aat         96
Leu Glu Gln Lys Asn Lys Phe Ile Arg Glu Leu Lys Thr Leu Lys Asn           
            20                  25                  30                    

cta cct tca gtc aag aat gga cgg ctc att gtc ggt agc ccc agc gcc        144
Leu Pro Ser Val Lys Asn Gly Arg Leu Ile Val Gly Ser Pro Ser Ala           
        35                  40                  45                        

acg gat ccc att gaa cga agc aaa ggg ttt caa ata gct ctt gtg agt        192
Thr Asp Pro Ile Glu Arg Ser Lys Gly Phe Gln Ile Ala Leu Val Ser           
    50                  55                  60                            

tac cac gaa aac ctg gcg gct ctg gca gaa tac caa gcc agc gag gac        240
Tyr His Glu Asn Leu Ala Ala Leu Ala Glu Tyr Gln Ala Ser Glu Asp           
65                  70                  75                  80            

cat cac cgg gta acg tct aca tac ttc att ccg tac aag gag gat ttg        288
His His Arg Val Thr Ser Thr Tyr Phe Ile Pro Tyr Lys Glu Asp Leu           
                85                  90                  95                

att cga ttt gat ttt gag gta gat gtt gag gac gaa tat atg tgt ggt        336
Ile Arg Phe Asp Phe Glu Val Asp Val Glu Asp Glu Tyr Met Cys Gly           
            100                 105                 110                   

ggc aac cgg ttc ggg agc tcc gct aac cta acg gat ctt ctc cgt cag        384
Gly Asn Arg Phe Gly Ser Ser Ala Asn Leu Thr Asp Leu Leu Arg Gln           
        115                 120                 125                       

acc ttt ttc tcc aca tct tct act tcc aca ggc tcg ttt acg tac ggg        432
Thr Phe Phe Ser Thr Ser Ser Thr Ser Thr Gly Ser Phe Thr Tyr Gly           
    130                 135                 140                           

cgc aat tgt caa gac gta agc acc aga ttt aca att gga cat tta gag        480
Arg Asn Cys Gln Asp Val Ser Thr Arg Phe Thr Ile Gly His Leu Glu           
145                 150                 155                 160           

gcc taa                                                                486
Ala                                                                       
                                                                          


<210>  75
<211>  161
<212>  PRT
<213>  Aspergillus nidulans

<400>  75

Met Leu Asn Asp Asp Ala Val Leu Phe Lys Phe Arg Ser Gly Val Thr 
1               5                   10                  15      


Leu Glu Gln Lys Asn Lys Phe Ile Arg Glu Leu Lys Thr Leu Lys Asn 
            20                  25                  30          


Leu Pro Ser Val Lys Asn Gly Arg Leu Ile Val Gly Ser Pro Ser Ala 
        35                  40                  45              


Thr Asp Pro Ile Glu Arg Ser Lys Gly Phe Gln Ile Ala Leu Val Ser 
    50                  55                  60                  


Tyr His Glu Asn Leu Ala Ala Leu Ala Glu Tyr Gln Ala Ser Glu Asp 
65                  70                  75                  80  


His His Arg Val Thr Ser Thr Tyr Phe Ile Pro Tyr Lys Glu Asp Leu 
                85                  90                  95      


Ile Arg Phe Asp Phe Glu Val Asp Val Glu Asp Glu Tyr Met Cys Gly 
            100                 105                 110         


Gly Asn Arg Phe Gly Ser Ser Ala Asn Leu Thr Asp Leu Leu Arg Gln 
        115                 120                 125             


Thr Phe Phe Ser Thr Ser Ser Thr Ser Thr Gly Ser Phe Thr Tyr Gly 
    130                 135                 140                 


Arg Asn Cys Gln Asp Val Ser Thr Arg Phe Thr Ile Gly His Leu Glu 
145                 150                 155                 160 


Ala 
    


<210>  76
<211>  309
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(309)
<223>  AOC-4 (type: Dabb) gene [GenBank ID number ANIA_11021) encoding a
       first small molecule foldase [GenBank ID number CBF80167.1]

<400>  76
atg ccg gta tat cac gtc gcc cta ttc aaa ctc aaa cca gac gcc gac         48
Met Pro Val Tyr His Val Ala Leu Phe Lys Leu Lys Pro Asp Ala Asp           
1               5                   10                  15                

cct aac cgt atc tgt tta tgg cag gag ctc gcg cac gca atg gtc ggc         96
Pro Asn Arg Ile Cys Leu Trp Gln Glu Leu Ala His Ala Met Val Gly           
            20                  25                  30                    

aag gta cct ggc cta ctg gat ctg caa gct ggg cct ccc ctc gac ttc        144
Lys Val Pro Gly Leu Leu Asp Leu Gln Ala Gly Pro Pro Leu Asp Phe           
        35                  40                  45                        

acg gct cga ctg gcg aaa ggg ttt gat atg ggt gta gtc gtg ctg cta        192
Thr Ala Arg Leu Ala Lys Gly Phe Asp Met Gly Val Val Val Leu Leu           
    50                  55                  60                            

gac tat gtg gag tct ctc gct acc atg ttt acg cat ccg agc cat gac        240
Asp Tyr Val Glu Ser Leu Ala Thr Met Phe Thr His Pro Ser His Asp           
65                  70                  75                  80            

caa gtt cac gaa ttg tac cag gag gtt tgc gag gac ggg agt act gtt        288
Gln Val His Glu Leu Tyr Gln Glu Val Cys Glu Asp Gly Ser Thr Val           
                85                  90                  95                

ggt tac gat att gaa ttc tag                                            309
Gly Tyr Asp Ile Glu Phe                                                   
            100                                                           


<210>  77
<211>  102
<212>  PRT
<213>  Aspergillus nidulans

<400>  77

Met Pro Val Tyr His Val Ala Leu Phe Lys Leu Lys Pro Asp Ala Asp 
1               5                   10                  15      


Pro Asn Arg Ile Cys Leu Trp Gln Glu Leu Ala His Ala Met Val Gly 
            20                  25                  30          


Lys Val Pro Gly Leu Leu Asp Leu Gln Ala Gly Pro Pro Leu Asp Phe 
        35                  40                  45              


Thr Ala Arg Leu Ala Lys Gly Phe Asp Met Gly Val Val Val Leu Leu 
    50                  55                  60                  


Asp Tyr Val Glu Ser Leu Ala Thr Met Phe Thr His Pro Ser His Asp 
65                  70                  75                  80  


Gln Val His Glu Leu Tyr Gln Glu Val Cys Glu Asp Gly Ser Thr Val 
                85                  90                  95      


Gly Tyr Asp Ile Glu Phe 
            100         


<210>  78
<211>  315
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(315)
<223>  AOC-5 (type: Dabb) gene [GenBank ID number AN1979.2) encoding a 
       first small molecule foldase [GenBank ID number XP_659583.1]

<400>  78
atg gcc ccc atc gag cgc atc acc ctt ttc aag atc ccc gac gaa gca         48
Met Ala Pro Ile Glu Arg Ile Thr Leu Phe Lys Ile Pro Asp Glu Ala           
1               5                   10                  15                

gcc cga gat cgt gtg ctg gag cag tac aag gtc ctt gcg aag acg gct         96
Ala Arg Asp Arg Val Leu Glu Gln Tyr Lys Val Leu Ala Lys Thr Ala           
            20                  25                  30                    

gtt aag gac ggc aaa ccg tac att gtc tcc gcc gca gca gga ccg acg        144
Val Lys Asp Gly Lys Pro Tyr Ile Val Ser Ala Ala Ala Gly Pro Thr           
        35                  40                  45                        

atc ccg gac ccg cga tgt aaa ggt ttc aat ctc tcc gtt aag aca acg        192
Ile Pro Asp Pro Arg Cys Lys Gly Phe Asn Leu Ser Val Lys Thr Thr           
    50                  55                  60                            

ttc gca tcg ctg gag gat atg aag tac tat gat aca gag tgt gag gcg        240
Phe Ala Ser Leu Glu Asp Met Lys Tyr Tyr Asp Thr Glu Cys Glu Ala           
65                  70                  75                  80            

cac aag gcg ttg aag gcg gtt gcg gcg ccg gtg aag gag gat gtt ttg        288
His Lys Ala Leu Lys Ala Val Ala Ala Pro Val Lys Glu Asp Val Leu           
                85                  90                  95                

acg act tac ttc gag agt gtg ctt tga                                    315
Thr Thr Tyr Phe Glu Ser Val Leu                                           
            100                                                           


<210>  79
<211>  104
<212>  PRT
<213>  Aspergillus nidulans

<400>  79

Met Ala Pro Ile Glu Arg Ile Thr Leu Phe Lys Ile Pro Asp Glu Ala 
1               5                   10                  15      


Ala Arg Asp Arg Val Leu Glu Gln Tyr Lys Val Leu Ala Lys Thr Ala 
            20                  25                  30          


Val Lys Asp Gly Lys Pro Tyr Ile Val Ser Ala Ala Ala Gly Pro Thr 
        35                  40                  45              


Ile Pro Asp Pro Arg Cys Lys Gly Phe Asn Leu Ser Val Lys Thr Thr 
    50                  55                  60                  


Phe Ala Ser Leu Glu Asp Met Lys Tyr Tyr Asp Thr Glu Cys Glu Ala 
65                  70                  75                  80  


His Lys Ala Leu Lys Ala Val Ala Ala Pro Val Lys Glu Asp Val Leu 
                85                  90                  95      


Thr Thr Tyr Phe Glu Ser Val Leu 
            100                 


<210>  80
<211>  771
<212>  DNA
<213>  Streptomyces sp. R1128


<220>
<221>  CDS
<222>  (1)..(771)
<223>  ZhuJ gene [GenBank ID number AF293442.1) encoding cylase [GenBank
       ID number AAG30196.1]

<400>  80
atg agc ggc cgc aag acg ttc ctc gac ctg agc ttc gcg acc cgg gac         48
Met Ser Gly Arg Lys Thr Phe Leu Asp Leu Ser Phe Ala Thr Arg Asp           
1               5                   10                  15                

acc ccc agc gag gcc acc ccg gtc gtc gtc gac ctg ctc gac cac gtg         96
Thr Pro Ser Glu Ala Thr Pro Val Val Val Asp Leu Leu Asp His Val           
            20                  25                  30                    

acc ggc gcg acg gtg ctc ggg ctg agc ccc gag gac ttc ccc gac ggc        144
Thr Gly Ala Thr Val Leu Gly Leu Ser Pro Glu Asp Phe Pro Asp Gly           
        35                  40                  45                        

atg gcc atc tcg aac gag acg gtc acc ctc acc acg cac acc ggc acg        192
Met Ala Ile Ser Asn Glu Thr Val Thr Leu Thr Thr His Thr Gly Thr           
    50                  55                  60                            

cac atg gac gcg ccg ctg cac tac ggc ccg ctc agc ggc ggc gtg ccg        240
His Met Asp Ala Pro Leu His Tyr Gly Pro Leu Ser Gly Gly Val Pro           
65                  70                  75                  80            

gcc aag tcg atc gac cag gtc ccg ctg gag tgg tgc tac ggc ccg ggc        288
Ala Lys Ser Ile Asp Gln Val Pro Leu Glu Trp Cys Tyr Gly Pro Gly           
                85                  90                  95                

gtg cgc ctg gac gtg cgg cac gtg ccg gcc ggc gac ggc atc acc gtc        336
Val Arg Leu Asp Val Arg His Val Pro Ala Gly Asp Gly Ile Thr Val           
            100                 105                 110                   

gac cac ctc aac gcc gcg ctc gac gcc gcc gag cac gac ctg gcg ccc        384
Asp His Leu Asn Ala Ala Leu Asp Ala Ala Glu His Asp Leu Ala Pro           
        115                 120                 125                       

ggc gac atc gtc atg ttg tgg acc ggc gcg gac gcc ctg tgg ggc acc        432
Gly Asp Ile Val Met Leu Trp Thr Gly Ala Asp Ala Leu Trp Gly Thr           
    130                 135                 140                           

cgc gag tac ctg tcc acc ttc ccc gga ctg acc ggc aag gga acg cag        480
Arg Glu Tyr Leu Ser Thr Phe Pro Gly Leu Thr Gly Lys Gly Thr Gln           
145                 150                 155                 160           

ttc ctg gtc gag gcg ggc gtg aag gtg atc ggc atc gac gcg tgg ggc        528
Phe Leu Val Glu Ala Gly Val Lys Val Ile Gly Ile Asp Ala Trp Gly           
                165                 170                 175               

ctg gac cgg ccg atg gcc gcg atg atc gag gag tac cgg cgt acc ggc        576
Leu Asp Arg Pro Met Ala Ala Met Ile Glu Glu Tyr Arg Arg Thr Gly           
            180                 185                 190                   

gac aag ggc gcc ttg tgg ccg gcg cac gtc tac ggg cgc acc cgc gaa        624
Asp Lys Gly Ala Leu Trp Pro Ala His Val Tyr Gly Arg Thr Arg Glu           
        195                 200                 205                       

tac ctc cag ttg gag aag ctc aac aac ctg ggc gcg ctg ccc ggc gcc        672
Tyr Leu Gln Leu Glu Lys Leu Asn Asn Leu Gly Ala Leu Pro Gly Ala           
    210                 215                 220                           

acc gga tac gac atc agt tgc ttc ccg gtc gcc gtc gcg ggc acc ggt        720
Thr Gly Tyr Asp Ile Ser Cys Phe Pro Val Ala Val Ala Gly Thr Gly           
225                 230                 235                 240           

gcg ggc tgg acc cgg gtg gtc gcc gtg ttc gag cag gaa gag gag gac        768
Ala Gly Trp Thr Arg Val Val Ala Val Phe Glu Gln Glu Glu Glu Asp           
                245                 250                 255               

tag                                                                    771


<210>  81
<211>  256
<212>  PRT
<213>  Streptomyces sp. R1128

<400>  81

Met Ser Gly Arg Lys Thr Phe Leu Asp Leu Ser Phe Ala Thr Arg Asp 
1               5                   10                  15      


Thr Pro Ser Glu Ala Thr Pro Val Val Val Asp Leu Leu Asp His Val 
            20                  25                  30          


Thr Gly Ala Thr Val Leu Gly Leu Ser Pro Glu Asp Phe Pro Asp Gly 
        35                  40                  45              


Met Ala Ile Ser Asn Glu Thr Val Thr Leu Thr Thr His Thr Gly Thr 
    50                  55                  60                  


His Met Asp Ala Pro Leu His Tyr Gly Pro Leu Ser Gly Gly Val Pro 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Gln Val Pro Leu Glu Trp Cys Tyr Gly Pro Gly 
                85                  90                  95      


Val Arg Leu Asp Val Arg His Val Pro Ala Gly Asp Gly Ile Thr Val 
            100                 105                 110         


Asp His Leu Asn Ala Ala Leu Asp Ala Ala Glu His Asp Leu Ala Pro 
        115                 120                 125             


Gly Asp Ile Val Met Leu Trp Thr Gly Ala Asp Ala Leu Trp Gly Thr 
    130                 135                 140                 


Arg Glu Tyr Leu Ser Thr Phe Pro Gly Leu Thr Gly Lys Gly Thr Gln 
145                 150                 155                 160 


Phe Leu Val Glu Ala Gly Val Lys Val Ile Gly Ile Asp Ala Trp Gly 
                165                 170                 175     


Leu Asp Arg Pro Met Ala Ala Met Ile Glu Glu Tyr Arg Arg Thr Gly 
            180                 185                 190         


Asp Lys Gly Ala Leu Trp Pro Ala His Val Tyr Gly Arg Thr Arg Glu 
        195                 200                 205             


Tyr Leu Gln Leu Glu Lys Leu Asn Asn Leu Gly Ala Leu Pro Gly Ala 
    210                 215                 220                 


Thr Gly Tyr Asp Ile Ser Cys Phe Pro Val Ala Val Ala Gly Thr Gly 
225                 230                 235                 240 


Ala Gly Trp Thr Arg Val Val Ala Val Phe Glu Gln Glu Glu Glu Asp 
                245                 250                 255     


<210>  82
<211>  774
<212>  DNA
<213>  Streptomyces rimosus


<220>
<221>  CDS
<222>  (1)..(774)
<223>  oxyN gene [GenBank ID number DQ143963.2 position 14855 to 15628) 
       encoding  cylase [GenBank ID number AAZ78337.1]

<400>  82
atg cgc atc atc gat ctg tcg aca acc gtg gac gcc ggc cgg tgg gag         48
Met Arg Ile Ile Asp Leu Ser Thr Thr Val Asp Ala Gly Arg Trp Glu           
1               5                   10                  15                

gtc gat ccg gtc gaa cac gaa atc ctc acc ccg gcc gag ggc ggc cgg         96
Val Asp Pro Val Glu His Glu Ile Leu Thr Pro Ala Glu Gly Gly Arg           
            20                  25                  30                    

cac atg gcc gag ggg atg cgg cgc cac cac ggc atc gac ttc gac ccc        144
His Met Ala Glu Gly Met Arg Arg His His Gly Ile Asp Phe Asp Pro           
        35                  40                  45                        

gcc gac ctc ccg gac ggc gaa ctg ctg tcc ctc gac acc ctg cgg ctg        192
Ala Asp Leu Pro Asp Gly Glu Leu Leu Ser Leu Asp Thr Leu Arg Leu           
    50                  55                  60                            

acc acc cac acc ggc acc cac gtc gac gcc ccg tcg cac tac ggg tcc        240
Thr Thr His Thr Gly Thr His Val Asp Ala Pro Ser His Tyr Gly Ser           
65                  70                  75                  80            

cgc gcg cgc tac ggc acg ccg cgc cac atc gac cag atg cca ctg gac        288
Arg Ala Arg Tyr Gly Thr Pro Arg His Ile Asp Gln Met Pro Leu Asp           
                85                  90                  95                

tgg ttt ctg cgg ccg ggc ctc aag ctc gac ctt acc gac gag ccg gtg        336
Trp Phe Leu Arg Pro Gly Leu Lys Leu Asp Leu Thr Asp Glu Pro Val           
            100                 105                 110                   

ggc gcc atc gga gcc gac cgg ata cgg cgg gcc ctc gac gaa gcg ggc        384
Gly Ala Ile Gly Ala Asp Arg Ile Arg Arg Ala Leu Asp Glu Ala Gly           
        115                 120                 125                       

cgc gac ccg cgt ccg tac gac atc gtg ctg ctg cac acc ggc gcg gac        432
Arg Asp Pro Arg Pro Tyr Asp Ile Val Leu Leu His Thr Gly Ala Asp           
    130                 135                 140                           

cgg cgg gcc gga aag ccg gag tac ttc acc gag ttc gcc ggc ctg gac        480
Arg Arg Ala Gly Lys Pro Glu Tyr Phe Thr Glu Phe Ala Gly Leu Asp           
145                 150                 155                 160           

gcc gcg gcg acc cac ctg ctg ctc gac ttc ggc gtc cgg gtc atc ggc        528
Ala Ala Ala Thr His Leu Leu Leu Asp Phe Gly Val Arg Val Ile Gly           
                165                 170                 175               

acc gac gcc ttc agc ctc gac gcc ccg ttc ggg cac atg atc aag gag        576
Thr Asp Ala Phe Ser Leu Asp Ala Pro Phe Gly His Met Ile Lys Glu           
            180                 185                 190                   

tac cag cgc acc ggc gac cgc ggt gtg ctg tgg ccc gcc cac ttc gtg        624
Tyr Gln Arg Thr Gly Asp Arg Gly Val Leu Trp Pro Ala His Phe Val           
        195                 200                 205                       

gga cgg gag cgc gag tac tgc cag atc gag cgg ctg gac aac ctc ggc        672
Gly Arg Glu Arg Glu Tyr Cys Gln Ile Glu Arg Leu Asp Asn Leu Gly           
    210                 215                 220                           

gcg ctg ccc gga ccg gac ggc ttc ttg gtc tcc tgc ttt ccg ttc aag        720
Ala Leu Pro Gly Pro Asp Gly Phe Leu Val Ser Cys Phe Pro Phe Lys           
225                 230                 235                 240           

atc gcg gga gcg ggg gcg ggg tgg acg cgg gcg gtg gcg gtg gtg gag        768
Ile Ala Gly Ala Gly Ala Gly Trp Thr Arg Ala Val Ala Val Val Glu           
                245                 250                 255               

gag tag                                                                774
Glu                                                                       
                                                                          


<210>  83
<211>  257
<212>  PRT
<213>  Streptomyces rimosus

<400>  83

Met Arg Ile Ile Asp Leu Ser Thr Thr Val Asp Ala Gly Arg Trp Glu 
1               5                   10                  15      


Val Asp Pro Val Glu His Glu Ile Leu Thr Pro Ala Glu Gly Gly Arg 
            20                  25                  30          


His Met Ala Glu Gly Met Arg Arg His His Gly Ile Asp Phe Asp Pro 
        35                  40                  45              


Ala Asp Leu Pro Asp Gly Glu Leu Leu Ser Leu Asp Thr Leu Arg Leu 
    50                  55                  60                  


Thr Thr His Thr Gly Thr His Val Asp Ala Pro Ser His Tyr Gly Ser 
65                  70                  75                  80  


Arg Ala Arg Tyr Gly Thr Pro Arg His Ile Asp Gln Met Pro Leu Asp 
                85                  90                  95      


Trp Phe Leu Arg Pro Gly Leu Lys Leu Asp Leu Thr Asp Glu Pro Val 
            100                 105                 110         


Gly Ala Ile Gly Ala Asp Arg Ile Arg Arg Ala Leu Asp Glu Ala Gly 
        115                 120                 125             


Arg Asp Pro Arg Pro Tyr Asp Ile Val Leu Leu His Thr Gly Ala Asp 
    130                 135                 140                 


Arg Arg Ala Gly Lys Pro Glu Tyr Phe Thr Glu Phe Ala Gly Leu Asp 
145                 150                 155                 160 


Ala Ala Ala Thr His Leu Leu Leu Asp Phe Gly Val Arg Val Ile Gly 
                165                 170                 175     


Thr Asp Ala Phe Ser Leu Asp Ala Pro Phe Gly His Met Ile Lys Glu 
            180                 185                 190         


Tyr Gln Arg Thr Gly Asp Arg Gly Val Leu Trp Pro Ala His Phe Val 
        195                 200                 205             


Gly Arg Glu Arg Glu Tyr Cys Gln Ile Glu Arg Leu Asp Asn Leu Gly 
    210                 215                 220                 


Ala Leu Pro Gly Pro Asp Gly Phe Leu Val Ser Cys Phe Pro Phe Lys 
225                 230                 235                 240 


Ile Ala Gly Ala Gly Ala Gly Trp Thr Arg Ala Val Ala Val Val Glu 
                245                 250                 255     


Glu 
    


<210>  84
<211>  330
<212>  DNA
<213>  Streptomyces venezuelae


<220>
<221>  CDS
<222>  (1)..(330)
<223>  jadI gene [GenBank ID number AAD37852.1 position 2020 to 2349 ) 
       encoding a polyketide cyclase [GenBank ID number AF126429.1]

<400>  84
atg cac agc act ctg atc gtg gcc cga atg gaa ccc gga tcg agc acc         48
Met His Ser Thr Leu Ile Val Ala Arg Met Glu Pro Gly Ser Ser Thr           
1               5                   10                  15                

gac gtg gcg aag ctg ttc gcc gaa ttc gac gcc tcc gag atg ccg cat         96
Asp Val Ala Lys Leu Phe Ala Glu Phe Asp Ala Ser Glu Met Pro His           
            20                  25                  30                    

ctc atg ggg acg cga cgc cgt cag ctg ttc tcg tac cgc ggc ctc tac        144
Leu Met Gly Thr Arg Arg Arg Gln Leu Phe Ser Tyr Arg Gly Leu Tyr           
        35                  40                  45                        

ttc cac ctc cag gac ttc gac gcc gac aac ggc ggc gag ctc atc gag        192
Phe His Leu Gln Asp Phe Asp Ala Asp Asn Gly Gly Glu Leu Ile Glu           
    50                  55                  60                            

cgg gcc aag acc gac ccc cgc ttc gtg ggc atc agc gag gac ctg aag        240
Arg Ala Lys Thr Asp Pro Arg Phe Val Gly Ile Ser Glu Asp Leu Lys           
65                  70                  75                  80            

ccg ttc atc gag gcc tac gac ccg gcc acc tgg cgc tcg ccc gcc gac        288
Pro Phe Ile Glu Ala Tyr Asp Pro Ala Thr Trp Arg Ser Pro Ala Asp           
                85                  90                  95                

gcc atg gcc acc cgc ttc tac aac tgg gag gcg aac gcg tga                330
Ala Met Ala Thr Arg Phe Tyr Asn Trp Glu Ala Asn Ala                       
            100                 105                                       


<210>  85
<211>  109
<212>  PRT
<213>  Streptomyces venezuelae

<400>  85

Met His Ser Thr Leu Ile Val Ala Arg Met Glu Pro Gly Ser Ser Thr 
1               5                   10                  15      


Asp Val Ala Lys Leu Phe Ala Glu Phe Asp Ala Ser Glu Met Pro His 
            20                  25                  30          


Leu Met Gly Thr Arg Arg Arg Gln Leu Phe Ser Tyr Arg Gly Leu Tyr 
        35                  40                  45              


Phe His Leu Gln Asp Phe Asp Ala Asp Asn Gly Gly Glu Leu Ile Glu 
    50                  55                  60                  


Arg Ala Lys Thr Asp Pro Arg Phe Val Gly Ile Ser Glu Asp Leu Lys 
65                  70                  75                  80  


Pro Phe Ile Glu Ala Tyr Asp Pro Ala Thr Trp Arg Ser Pro Ala Asp 
                85                  90                  95      


Ala Met Ala Thr Arg Phe Tyr Asn Trp Glu Ala Asn Ala 
            100                 105                 


<210>  86
<211>  330
<212>  DNA
<213>  Streptomyces globisporus


<220>
<221>  CDS
<222>  (1)..(330)
<223>  LndF gene [GenBank ID number AY659997.1) encoding a polyketide 
       cyclase [GenBank ID number AAU04837.1]

<400>  86
atg cac agc aca ctg atc gtc gcc cgg atg gac ccc gcg tcg agc atc         48
Met His Ser Thr Leu Ile Val Ala Arg Met Asp Pro Ala Ser Ser Ile           
1               5                   10                  15                

gac gtg gcg gaa ctc ttc ggc gag ttc gac cgc acc gag atg ccc cac         96
Asp Val Ala Glu Leu Phe Gly Glu Phe Asp Arg Thr Glu Met Pro His           
            20                  25                  30                    

cgc atg ggc acc agg cgt cgg cag ctc ttc tcg tat cgc gga ctg tac        144
Arg Met Gly Thr Arg Arg Arg Gln Leu Phe Ser Tyr Arg Gly Leu Tyr           
        35                  40                  45                        

ttc cac ctg cag gac ttc gac tcc gac aac ggc gga gag ctg atc gag        192
Phe His Leu Gln Asp Phe Asp Ser Asp Asn Gly Gly Glu Leu Ile Glu           
    50                  55                  60                            

gag gcc aag agc gac ccg cgc ttc gcg gcg atc agc cag gac ctg aag        240
Glu Ala Lys Ser Asp Pro Arg Phe Ala Ala Ile Ser Gln Asp Leu Lys           
65                  70                  75                  80            

ccc ttc atc gaa gcg tac gac ccg gcc acc tgg cgt tcc ccg gcc gat        288
Pro Phe Ile Glu Ala Tyr Asp Pro Ala Thr Trp Arg Ser Pro Ala Asp           
                85                  90                  95                

gcg atg gcc acc cgc ttc tac aac tgg acg acg tcg tca taa                330
Ala Met Ala Thr Arg Phe Tyr Asn Trp Thr Thr Ser Ser                       
            100                 105                                       


<210>  87
<211>  109
<212>  PRT
<213>  Streptomyces globisporus

<400>  87

Met His Ser Thr Leu Ile Val Ala Arg Met Asp Pro Ala Ser Ser Ile 
1               5                   10                  15      


Asp Val Ala Glu Leu Phe Gly Glu Phe Asp Arg Thr Glu Met Pro His 
            20                  25                  30          


Arg Met Gly Thr Arg Arg Arg Gln Leu Phe Ser Tyr Arg Gly Leu Tyr 
        35                  40                  45              


Phe His Leu Gln Asp Phe Asp Ser Asp Asn Gly Gly Glu Leu Ile Glu 
    50                  55                  60                  


Glu Ala Lys Ser Asp Pro Arg Phe Ala Ala Ile Ser Gln Asp Leu Lys 
65                  70                  75                  80  


Pro Phe Ile Glu Ala Tyr Asp Pro Ala Thr Trp Arg Ser Pro Ala Asp 
                85                  90                  95      


Ala Met Ala Thr Arg Phe Tyr Asn Trp Thr Thr Ser Ser 
            100                 105                 


<210>  88
<211>  336
<212>  DNA
<213>  Streptomyces coelicoflavus


<220>
<221>  CDS
<222>  (1)..(336)
<223>  pgaF gene [GenBank ID number AHGS01000054.1 position 6389 to 
       6724) encoding a polyketide cyclase [GenBank ID number 
       EHN79050.1]

<400>  88
atg gtc gcg cga atg gac gcg gcg aat tcc acg gaa gtg tcg agg ctg         48
Met Val Ala Arg Met Asp Ala Ala Asn Ser Thr Glu Val Ser Arg Leu           
1               5                   10                  15                

ttc tcc gcg tcg gac gcc acg tcc ctg ccg cac gat ctc ggc gtg cgc         96
Phe Ser Ala Ser Asp Ala Thr Ser Leu Pro His Asp Leu Gly Val Arg           
            20                  25                  30                    

ggg cgt cgg ctc ttt cgc tat cac ggc ctg tac ttc cat ctc gtc gaa        144
Gly Arg Arg Leu Phe Arg Tyr His Gly Leu Tyr Phe His Leu Val Glu           
        35                  40                  45                        

ttc gac ggc acc cac acc gac ccg gtg gcc gtg gcc cgc ggc cgt gcg        192
Phe Asp Gly Thr His Thr Asp Pro Val Ala Val Ala Arg Gly Arg Ala           
    50                  55                  60                            

gac ttc cag cgg ctc agc gag gaa ctg agc ccg ttc gtg ctg ccc ttc        240
Asp Phe Gln Arg Leu Ser Glu Glu Leu Ser Pro Phe Val Leu Pro Phe           
65                  70                  75                  80            

gaa ccg gcg acc tgg cgg ggg ccg gag tcg gcc atg gcg gag gag ttc        288
Glu Pro Ala Thr Trp Arg Gly Pro Glu Ser Ala Met Ala Glu Glu Phe           
                85                  90                  95                

tac tcc tgg acc gcc gcc ccg gcg gtg ccc ccc cgg ccc gcg ggc tga        336
Tyr Ser Trp Thr Ala Ala Pro Ala Val Pro Pro Arg Pro Ala Gly               
            100                 105                 110                   


<210>  89
<211>  111
<212>  PRT
<213>  Streptomyces coelicoflavus

<400>  89

Met Val Ala Arg Met Asp Ala Ala Asn Ser Thr Glu Val Ser Arg Leu 
1               5                   10                  15      


Phe Ser Ala Ser Asp Ala Thr Ser Leu Pro His Asp Leu Gly Val Arg 
            20                  25                  30          


Gly Arg Arg Leu Phe Arg Tyr His Gly Leu Tyr Phe His Leu Val Glu 
        35                  40                  45              


Phe Asp Gly Thr His Thr Asp Pro Val Ala Val Ala Arg Gly Arg Ala 
    50                  55                  60                  


Asp Phe Gln Arg Leu Ser Glu Glu Leu Ser Pro Phe Val Leu Pro Phe 
65                  70                  75                  80  


Glu Pro Ala Thr Trp Arg Gly Pro Glu Ser Ala Met Ala Glu Glu Phe 
                85                  90                  95      


Tyr Ser Trp Thr Ala Ala Pro Ala Val Pro Pro Arg Pro Ala Gly 
            100                 105                 110     


<210>  90
<211>  894
<212>  DNA
<213>  Streptomyces coelicolor


<220>
<221>  CDS
<222>  (1)..(894)
<223>  Act_CYC gene [GenBank ID number X63449.1 Position 3830 to 4723) 
       encoding GenBank ID number CAA45047.1

<400>  90
atg acg gtc gag gtc cgt gag gtc gcc gag ggt gtc tac gcc tac gag         48
Met Thr Val Glu Val Arg Glu Val Ala Glu Gly Val Tyr Ala Tyr Glu           
1               5                   10                  15                

cag gcc ccc ggc ggc tgg tgc gtc agc aac gcg ggc atc gtg gtg ggc         96
Gln Ala Pro Gly Gly Trp Cys Val Ser Asn Ala Gly Ile Val Val Gly           
            20                  25                  30                    

ggc gac ggc gcg ctc gtc gtc gac acg ctg tcg acg atc ccg agg gcg        144
Gly Asp Gly Ala Leu Val Val Asp Thr Leu Ser Thr Ile Pro Arg Ala           
        35                  40                  45                        

cgg cgg ctg gcg gag tgg gtc gac aag ctc gcc gcg ggc ccc ggc cgt        192
Arg Arg Leu Ala Glu Trp Val Asp Lys Leu Ala Ala Gly Pro Gly Arg           
    50                  55                  60                            

acc gtg gtc aac acc cac ttc cac ggc gac cac gcc ttc ggc aac cag        240
Thr Val Val Asn Thr His Phe His Gly Asp His Ala Phe Gly Asn Gln           
65                  70                  75                  80            

gtc ttc gcg ccg ggg acg cgg atc atc gcg cac gag gac atg cgg tcc        288
Val Phe Ala Pro Gly Thr Arg Ile Ile Ala His Glu Asp Met Arg Ser           
                85                  90                  95                

gcc atg gtg acg acc ggc ctg gcc ctc acc ggg ctc tgg ccg cgg gtc        336
Ala Met Val Thr Thr Gly Leu Ala Leu Thr Gly Leu Trp Pro Arg Val           
            100                 105                 110                   

gac tgg ggc gag atc gag ctg agg ccg ccg aac gtg acc ttc cgc gac        384
Asp Trp Gly Glu Ile Glu Leu Arg Pro Pro Asn Val Thr Phe Arg Asp           
        115                 120                 125                       

cgg ttg acc ctg cac gtc ggc gag cga cag gtc gaa ctg atc tgc gtc        432
Arg Leu Thr Leu His Val Gly Glu Arg Gln Val Glu Leu Ile Cys Val           
    130                 135                 140                           

ggc ccc gcg cac acc gat cac gac gtg gtg gtc tgg ctg ccc gag gag        480
Gly Pro Ala His Thr Asp His Asp Val Val Val Trp Leu Pro Glu Glu           
145                 150                 155                 160           

cgg gtg ctg ttc gcg ggg gac gtc gtc atg tcg ggc gtc act ccg ttc        528
Arg Val Leu Phe Ala Gly Asp Val Val Met Ser Gly Val Thr Pro Phe           
                165                 170                 175               

gcc ctc ttc ggt tcg gtg gcc ggc acg ctg gcc gcg ctc gac cgg ctg        576
Ala Leu Phe Gly Ser Val Ala Gly Thr Leu Ala Ala Leu Asp Arg Leu           
            180                 185                 190                   

gcg gag ctg gag ccc gag gtg gtc gtc ggc ggg cac ggc ccg gtg gcg        624
Ala Glu Leu Glu Pro Glu Val Val Val Gly Gly His Gly Pro Val Ala           
        195                 200                 205                       

gga ccc gag gtg atc gac gcc aac cgg gac tat ctg cgc tgg gtc cag        672
Gly Pro Glu Val Ile Asp Ala Asn Arg Asp Tyr Leu Arg Trp Val Gln           
    210                 215                 220                           

cgc ctc gcc gcc gat gcg gtc gac cgc cgg ctg aca ccg ttg cag gcc        720
Arg Leu Ala Ala Asp Ala Val Asp Arg Arg Leu Thr Pro Leu Gln Ala           
225                 230                 235                 240           

gcg cgc cgg gcg gac ctc ggc gcc ttc gcc ggg ctg ctg gac gcg gag        768
Ala Arg Arg Ala Asp Leu Gly Ala Phe Ala Gly Leu Leu Asp Ala Glu           
                245                 250                 255               

cgc ctc gtc gcg aac ctg cac cgg gcc cac gag gag ctg ctg ggc ggg        816
Arg Leu Val Ala Asn Leu His Arg Ala His Glu Glu Leu Leu Gly Gly           
            260                 265                 270                   

cac gtg cgt gac gcc atg gag atc ttc gcg gag ctg gtc gcc tac aac        864
His Val Arg Asp Ala Met Glu Ile Phe Ala Glu Leu Val Ala Tyr Asn           
        275                 280                 285                       

ggt ggg cag ctg ccc acc tgc ctc gcc tag                                894
Gly Gly Gln Leu Pro Thr Cys Leu Ala                                       
    290                 295                                               


<210>  91
<211>  297
<212>  PRT
<213>  Streptomyces coelicolor

<400>  91

Met Thr Val Glu Val Arg Glu Val Ala Glu Gly Val Tyr Ala Tyr Glu 
1               5                   10                  15      


Gln Ala Pro Gly Gly Trp Cys Val Ser Asn Ala Gly Ile Val Val Gly 
            20                  25                  30          


Gly Asp Gly Ala Leu Val Val Asp Thr Leu Ser Thr Ile Pro Arg Ala 
        35                  40                  45              


Arg Arg Leu Ala Glu Trp Val Asp Lys Leu Ala Ala Gly Pro Gly Arg 
    50                  55                  60                  


Thr Val Val Asn Thr His Phe His Gly Asp His Ala Phe Gly Asn Gln 
65                  70                  75                  80  


Val Phe Ala Pro Gly Thr Arg Ile Ile Ala His Glu Asp Met Arg Ser 
                85                  90                  95      


Ala Met Val Thr Thr Gly Leu Ala Leu Thr Gly Leu Trp Pro Arg Val 
            100                 105                 110         


Asp Trp Gly Glu Ile Glu Leu Arg Pro Pro Asn Val Thr Phe Arg Asp 
        115                 120                 125             


Arg Leu Thr Leu His Val Gly Glu Arg Gln Val Glu Leu Ile Cys Val 
    130                 135                 140                 


Gly Pro Ala His Thr Asp His Asp Val Val Val Trp Leu Pro Glu Glu 
145                 150                 155                 160 


Arg Val Leu Phe Ala Gly Asp Val Val Met Ser Gly Val Thr Pro Phe 
                165                 170                 175     


Ala Leu Phe Gly Ser Val Ala Gly Thr Leu Ala Ala Leu Asp Arg Leu 
            180                 185                 190         


Ala Glu Leu Glu Pro Glu Val Val Val Gly Gly His Gly Pro Val Ala 
        195                 200                 205             


Gly Pro Glu Val Ile Asp Ala Asn Arg Asp Tyr Leu Arg Trp Val Gln 
    210                 215                 220                 


Arg Leu Ala Ala Asp Ala Val Asp Arg Arg Leu Thr Pro Leu Gln Ala 
225                 230                 235                 240 


Ala Arg Arg Ala Asp Leu Gly Ala Phe Ala Gly Leu Leu Asp Ala Glu 
                245                 250                 255     


Arg Leu Val Ala Asn Leu His Arg Ala His Glu Glu Leu Leu Gly Gly 
            260                 265                 270         


His Val Arg Asp Ala Met Glu Ile Phe Ala Glu Leu Val Ala Tyr Asn 
        275                 280                 285             


Gly Gly Gln Leu Pro Thr Cys Leu Ala 
    290                 295         


<210>  92
<211>  570
<212>  DNA
<213>  Streptomyces ansochromogenes


<220>
<221>  CDS
<222>  (1)..(570)
<223>  sanE gene [GenBank ID number AF228524.1 position 15 to 584] 
       encoding a cyclase [ GenBank ID number AAF61923.1]

<400>  92
atg gct cgg cct ggc cgc cgt ctg cgc ggg gac ggc ccc tgt cgg tcg         48
Met Ala Arg Pro Gly Arg Arg Leu Arg Gly Asp Gly Pro Cys Arg Ser           
1               5                   10                  15                

ggt tcc tca cgc ggc cca ccc ggc cgg tgg cgg cgc ccg cgg ccg cgc         96
Gly Ser Ser Arg Gly Pro Pro Gly Arg Trp Arg Arg Pro Arg Pro Arg           
            20                  25                  30                    

cgc tgc ggc gga tcg tcg tcg gcg gga tca gcg gcg cgg gca aga cga        144
Arg Cys Gly Gly Ser Ser Ser Ala Gly Ser Ala Ala Arg Ala Arg Arg           
        35                  40                  45                        

cgc tgg ccg ccg ccc tgg ccg ggg cgc tgg aca tca ggc aca tcg aga        192
Arg Trp Pro Pro Pro Trp Pro Gly Arg Trp Thr Ser Gly Thr Ser Arg           
    50                  55                  60                            

tgg acg cgc tct acc acg gtc ccg gct gga ccc acc ggg cgg agt tcg        240
Trp Thr Arg Ser Thr Thr Val Pro Ala Gly Pro Thr Gly Arg Ser Ser           
65                  70                  75                  80            

cgg acg acg tgg agc gcg cca cgc ggg cac cgg cgt gga tct gcg acg        288
Arg Thr Thr Trp Ser Ala Pro Arg Gly His Arg Arg Gly Ser Ala Thr           
                85                  90                  95                

ccc agt acc act ggg tcg tcg gcg acc tgc tcg gcg agc gcg ccg aca        336
Pro Ser Thr Thr Gly Ser Ser Ala Thr Cys Ser Ala Ser Ala Pro Thr           
            100                 105                 110                   

cgt tcg tct ggc tcg acc tgc ccc gcc gga ccg tca tgc gcc gcg tgc        384
Arg Ser Ser Gly Ser Thr Cys Pro Ala Gly Pro Ser Cys Ala Ala Cys           
        115                 120                 125                       

tgc ggc gct cgg tgg tcc ggg ccg cca cgg gcc ggg aac tgt ggc acg        432
Cys Gly Ala Arg Trp Ser Gly Pro Pro Arg Ala Gly Asn Cys Gly Thr           
    130                 135                 140                           

gca acc ggg aga cct ggc ggt cga tgc tgc gca acc cgc gcc acc cgc        480
Ala Thr Gly Arg Pro Gly Gly Arg Cys Cys Ala Thr Arg Ala Thr Arg           
145                 150                 155                 160           

tgc gct ggg cct ggt ccc agc acg cca ccc ggc ggg ccg aga cgg ccg        528
Cys Ala Gly Pro Gly Pro Ser Thr Pro Pro Gly Gly Pro Arg Arg Pro           
                165                 170                 175               

ctt tcc tcg gcc tgc acc ccg gcc tca ccg tcg tcc acc tga                570
Leu Ser Ser Ala Cys Thr Pro Ala Ser Pro Ser Ser Thr                       
            180                 185                                       


<210>  93
<211>  189
<212>  PRT
<213>  Streptomyces ansochromogenes

<400>  93

Met Ala Arg Pro Gly Arg Arg Leu Arg Gly Asp Gly Pro Cys Arg Ser 
1               5                   10                  15      


Gly Ser Ser Arg Gly Pro Pro Gly Arg Trp Arg Arg Pro Arg Pro Arg 
            20                  25                  30          


Arg Cys Gly Gly Ser Ser Ser Ala Gly Ser Ala Ala Arg Ala Arg Arg 
        35                  40                  45              


Arg Trp Pro Pro Pro Trp Pro Gly Arg Trp Thr Ser Gly Thr Ser Arg 
    50                  55                  60                  


Trp Thr Arg Ser Thr Thr Val Pro Ala Gly Pro Thr Gly Arg Ser Ser 
65                  70                  75                  80  


Arg Thr Thr Trp Ser Ala Pro Arg Gly His Arg Arg Gly Ser Ala Thr 
                85                  90                  95      


Pro Ser Thr Thr Gly Ser Ser Ala Thr Cys Ser Ala Ser Ala Pro Thr 
            100                 105                 110         


Arg Ser Ser Gly Ser Thr Cys Pro Ala Gly Pro Ser Cys Ala Ala Cys 
        115                 120                 125             


Cys Gly Ala Arg Trp Ser Gly Pro Pro Arg Ala Gly Asn Cys Gly Thr 
    130                 135                 140                 


Ala Thr Gly Arg Pro Gly Gly Arg Cys Cys Ala Thr Arg Ala Thr Arg 
145                 150                 155                 160 


Cys Ala Gly Pro Gly Pro Ser Thr Pro Pro Gly Gly Pro Arg Arg Pro 
                165                 170                 175     


Leu Ser Ser Ala Cys Thr Pro Ala Ser Pro Ser Ser Thr 
            180                 185                 


<210>  94
<211>  324
<212>  DNA
<213>  Streptomyces sp. TA-0256


<220>
<221>  CDS
<222>  (1)..(324)
<223>  pnxK gene [GenBank ID number AB469194.1 position 13057 to 13380) 
       enclding a polyketide cyclase [GenBank ID number BAJ52679.1]

<400>  94
atg tat cag aac ctg atc gtc gcc cgg atg gat cct gcg gag gcg gac         48
Met Tyr Gln Asn Leu Ile Val Ala Arg Met Asp Pro Ala Glu Ala Asp           
1               5                   10                  15                

tcc gtc gcg aag atc ttc gcg gaa tcg gac gct tcc gac ttg ccg cac         96
Ser Val Ala Lys Ile Phe Ala Glu Ser Asp Ala Ser Asp Leu Pro His           
            20                  25                  30                    

agg atc gga gtg tcc cgg cgg acg ctg tgg cgc ttc cac gat ctg tac        144
Arg Ile Gly Val Ser Arg Arg Thr Leu Trp Arg Phe His Asp Leu Tyr           
        35                  40                  45                        

ttc cac ctc gtg gag ggc gag gag gac atc acg ccg aac ctc tac cgg        192
Phe His Leu Val Glu Gly Glu Glu Asp Ile Thr Pro Asn Leu Tyr Arg           
    50                  55                  60                            

gcg cgc agc cac ccg ctc tac gag gac atc cac gtg aag ctc gcc agg        240
Ala Arg Ser His Pro Leu Tyr Glu Asp Ile His Val Lys Leu Ala Arg           
65                  70                  75                  80            

cac atc cgg ccg tac gac ccc gcg tgg agc gag ccg aag gac gcc atg        288
His Ile Arg Pro Tyr Asp Pro Ala Trp Ser Glu Pro Lys Asp Ala Met           
                85                  90                  95                

gcc agc ccg ttc tac acc tgg gag aac cgg cgg tga                        324
Ala Ser Pro Phe Tyr Thr Trp Glu Asn Arg Arg                               
            100                 105                                       


<210>  95
<211>  107
<212>  PRT
<213>  Streptomyces sp. TA-0256

<400>  95

Met Tyr Gln Asn Leu Ile Val Ala Arg Met Asp Pro Ala Glu Ala Asp 
1               5                   10                  15      


Ser Val Ala Lys Ile Phe Ala Glu Ser Asp Ala Ser Asp Leu Pro His 
            20                  25                  30          


Arg Ile Gly Val Ser Arg Arg Thr Leu Trp Arg Phe His Asp Leu Tyr 
        35                  40                  45              


Phe His Leu Val Glu Gly Glu Glu Asp Ile Thr Pro Asn Leu Tyr Arg 
    50                  55                  60                  


Ala Arg Ser His Pro Leu Tyr Glu Asp Ile His Val Lys Leu Ala Arg 
65                  70                  75                  80  


His Ile Arg Pro Tyr Asp Pro Ala Trp Ser Glu Pro Lys Asp Ala Met 
                85                  90                  95      


Ala Ser Pro Phe Tyr Thr Trp Glu Asn Arg Arg 
            100                 105         


<210>  96
<211>  525
<212>  DNA
<213>  Streptomyces sp. TA-0256


<220>
<221>  CDS
<222>  (1)..(525)
<223>  pnxL gene [GenBank ID number AB469194.1 position 13377 to 13901 )
       encoding Cupin_2  type cyclase [GenBank ID number BAJ52680.1]

<400>  96
atg agc ccc gac gcg acc aag gcg acc aag ccg acg gca acc aag gcg         48
Met Ser Pro Asp Ala Thr Lys Ala Thr Lys Pro Thr Ala Thr Lys Ala           
1               5                   10                  15                

acc gac gtg acc ccg gca ccc gaa gtg acc cag gtg acg aac gtg acc         96
Thr Asp Val Thr Pro Ala Pro Glu Val Thr Gln Val Thr Asn Val Thr           
            20                  25                  30                    

aag gtg gcc ttc acc gac atc aag ccg aac cgg cgc agg ggc ggc gac        144
Lys Val Ala Phe Thr Asp Ile Lys Pro Asn Arg Arg Arg Gly Gly Asp           
        35                  40                  45                        

gtc cgc gtc ctg ctg agc ccg ctg acg gcc ggt gcc acc tcg ggg ttc        192
Val Arg Val Leu Leu Ser Pro Leu Thr Ala Gly Ala Thr Ser Gly Phe           
    50                  55                  60                            

atg ggc acg gtg acg ctg gag ccc ggc gag cac gtc tgc gag cac tac        240
Met Gly Thr Val Thr Leu Glu Pro Gly Glu His Val Cys Glu His Tyr           
65                  70                  75                  80            

cac ccg tac tcc gag gag ttc gtc cac ctg gtc cgc ggg acc gtc gtg        288
His Pro Tyr Ser Glu Glu Phe Val His Leu Val Arg Gly Thr Val Val           
                85                  90                  95                

ctc acc atc ggc ggc acc acg ctc acc ctg gag ccc ggg gac tcg gcc        336
Leu Thr Ile Gly Gly Thr Thr Leu Thr Leu Glu Pro Gly Asp Ser Ala           
            100                 105                 110                   

ctg gtc ccc atc ggt gtg cgc cac cgg ctg gtg aac gcc ggc tct gta        384
Leu Val Pro Ile Gly Val Arg His Arg Leu Val Asn Ala Gly Ser Val           
        115                 120                 125                       

gcg gca cag gcc gtc ttc cat ctg ggg ccg ctg gcg ccc cgc ccg gaa        432
Ala Ala Gln Ala Val Phe His Leu Gly Pro Leu Ala Pro Arg Pro Glu           
    130                 135                 140                           

ctc ggc cac gtc gac acc gag ttc ctg ccc ggc gcc cgc gac gag ccc        480
Leu Gly His Val Asp Thr Glu Phe Leu Pro Gly Ala Arg Asp Glu Pro           
145                 150                 155                 160           

gtg ctc gaa gtc ggc gga ggc gga acc ccc ggg gcg ggc tca tga            525
Val Leu Glu Val Gly Gly Gly Gly Thr Pro Gly Ala Gly Ser                   
                165                 170                                   


<210>  97
<211>  174
<212>  PRT
<213>  Streptomyces sp. TA-0256

<400>  97

Met Ser Pro Asp Ala Thr Lys Ala Thr Lys Pro Thr Ala Thr Lys Ala 
1               5                   10                  15      


Thr Asp Val Thr Pro Ala Pro Glu Val Thr Gln Val Thr Asn Val Thr 
            20                  25                  30          


Lys Val Ala Phe Thr Asp Ile Lys Pro Asn Arg Arg Arg Gly Gly Asp 
        35                  40                  45              


Val Arg Val Leu Leu Ser Pro Leu Thr Ala Gly Ala Thr Ser Gly Phe 
    50                  55                  60                  


Met Gly Thr Val Thr Leu Glu Pro Gly Glu His Val Cys Glu His Tyr 
65                  70                  75                  80  


His Pro Tyr Ser Glu Glu Phe Val His Leu Val Arg Gly Thr Val Val 
                85                  90                  95      


Leu Thr Ile Gly Gly Thr Thr Leu Thr Leu Glu Pro Gly Asp Ser Ala 
            100                 105                 110         


Leu Val Pro Ile Gly Val Arg His Arg Leu Val Asn Ala Gly Ser Val 
        115                 120                 125             


Ala Ala Gln Ala Val Phe His Leu Gly Pro Leu Ala Pro Arg Pro Glu 
    130                 135                 140                 


Leu Gly His Val Asp Thr Glu Phe Leu Pro Gly Ala Arg Asp Glu Pro 
145                 150                 155                 160 


Val Leu Glu Val Gly Gly Gly Gly Thr Pro Gly Ala Gly Ser 
                165                 170                 


<210>  98
<211>  429
<212>  DNA
<213>  Streptomyces tendae


<220>
<221>  CDS
<222>  (1)..(429)
<223>  llpCII gene [GenBank ID number AM492533.1 position 12120 to 
       12548)  encoding a Cupin_2 enzyme [GenBank ID number CAM34346.1]

<400>  98
atg acc gcg gag cgc agg ctg aag gtc aac gcg cgg gag gtc tcc gcg         48
Met Thr Ala Glu Arg Arg Leu Lys Val Asn Ala Arg Glu Val Ser Ala           
1               5                   10                  15                

aac cgc agg cgc ggc gga gag ctg cgg gtg acc gtc agc ccc agg acg         96
Asn Arg Arg Arg Gly Gly Glu Leu Arg Val Thr Val Ser Pro Arg Thr           
            20                  25                  30                    

gtc ggc tgc acc tcc gga ttc ggc ggc ctg ctg agg ctg gag ccc ggt        144
Val Gly Cys Thr Ser Gly Phe Gly Gly Leu Leu Arg Leu Glu Pro Gly           
        35                  40                  45                        

gag ttc gtc acc gag cac tac cac ccg tac tcc gag gag ttc ctg cac        192
Glu Phe Val Thr Glu His Tyr His Pro Tyr Ser Glu Glu Phe Leu His           
    50                  55                  60                            

gtg atc tcg ggc cgg ctg gag atg acc ctg gac ggc gaa ccg gtc cgg        240
Val Ile Ser Gly Arg Leu Glu Met Thr Leu Asp Gly Glu Pro Val Arg           
65                  70                  75                  80            

ctc ggc ccc gga gac tcg ctg tac gtc ccg atc ggg gtg cgg cac cgg        288
Leu Gly Pro Gly Asp Ser Leu Tyr Val Pro Ile Gly Val Arg His Arg           
                85                  90                  95                

ctg gtg aac acc ggc gac gaa ccg gcg acc ggc gtg ttc cac ctc tcg        336
Leu Val Asn Thr Gly Asp Glu Pro Ala Thr Gly Val Phe His Leu Ser           
            100                 105                 110                   

ccc ctg gca ccg cgg ccc gaa ctc ggc cac gtc gac acc gag ccg gtg        384
Pro Leu Ala Pro Arg Pro Glu Leu Gly His Val Asp Thr Glu Pro Val           
        115                 120                 125                       

ccg gcg gcc gac gag gcg cta ccg gac gtc ggg acc gcg acg tga            429
Pro Ala Ala Asp Glu Ala Leu Pro Asp Val Gly Thr Ala Thr                   
    130                 135                 140                           


<210>  99
<211>  142
<212>  PRT
<213>  Streptomyces tendae

<400>  99

Met Thr Ala Glu Arg Arg Leu Lys Val Asn Ala Arg Glu Val Ser Ala 
1               5                   10                  15      


Asn Arg Arg Arg Gly Gly Glu Leu Arg Val Thr Val Ser Pro Arg Thr 
            20                  25                  30          


Val Gly Cys Thr Ser Gly Phe Gly Gly Leu Leu Arg Leu Glu Pro Gly 
        35                  40                  45              


Glu Phe Val Thr Glu His Tyr His Pro Tyr Ser Glu Glu Phe Leu His 
    50                  55                  60                  


Val Ile Ser Gly Arg Leu Glu Met Thr Leu Asp Gly Glu Pro Val Arg 
65                  70                  75                  80  


Leu Gly Pro Gly Asp Ser Leu Tyr Val Pro Ile Gly Val Arg His Arg 
                85                  90                  95      


Leu Val Asn Thr Gly Asp Glu Pro Ala Thr Gly Val Phe His Leu Ser 
            100                 105                 110         


Pro Leu Ala Pro Arg Pro Glu Leu Gly His Val Asp Thr Glu Pro Val 
        115                 120                 125             


Pro Ala Ala Asp Glu Ala Leu Pro Asp Val Gly Thr Ala Thr 
    130                 135                 140         


<210>  100
<211>  336
<212>  DNA
<213>  Streptomyces tendae


<220>
<221>  CDS
<222>  (1)..(336)
<223>  llpCIII gene [GenBank ID number AM492533.1 position 12545 to 
       12880] enclding a  Polyketide cyclase [GenBank ID number 
       CAM34347.1]

<400>  100
atg cac cgc acc ctg atc gtc gcc agg ctg aaa acc ggc aat ccc gcc         48
Met His Arg Thr Leu Ile Val Ala Arg Leu Lys Thr Gly Asn Pro Ala           
1               5                   10                  15                

cgg atc gcg gag gtg ttc ggc gca tcg gac gcg acg gag ctg ccg cac         96
Arg Ile Ala Glu Val Phe Gly Ala Ser Asp Ala Thr Glu Leu Pro His           
            20                  25                  30                    

atg gtc ggc gtg tcc cgg cgg acc ctg ttc acc ttc cac gac ctg tac        144
Met Val Gly Val Ser Arg Arg Thr Leu Phe Thr Phe His Asp Leu Tyr           
        35                  40                  45                        

ttc cac ctc gtc gag gcc gac gag gac atc acc ccg aac ctg tac cgg        192
Phe His Leu Val Glu Ala Asp Glu Asp Ile Thr Pro Asn Leu Tyr Arg           
    50                  55                  60                            

gcc cgc agc cac ccg ctg tac gcc gac gtc aac aaa cgg ctc ggc gaa        240
Ala Arg Ser His Pro Leu Tyr Ala Asp Val Asn Lys Arg Leu Gly Glu           
65                  70                  75                  80            

ctc gtc gcg ccc tac gac ccc ggc tgg aag gaa ccg aag gac gcc atg        288
Leu Val Ala Pro Tyr Asp Pro Gly Trp Lys Glu Pro Lys Asp Ala Met           
                85                  90                  95                

gca tca ccg ttc tac acc tgg acc gcc gag cag ggc agg atc cgg tga        336
Ala Ser Pro Phe Tyr Thr Trp Thr Ala Glu Gln Gly Arg Ile Arg               
            100                 105                 110                   


<210>  101
<211>  111
<212>  PRT
<213>  Streptomyces tendae

<400>  101

Met His Arg Thr Leu Ile Val Ala Arg Leu Lys Thr Gly Asn Pro Ala 
1               5                   10                  15      


Arg Ile Ala Glu Val Phe Gly Ala Ser Asp Ala Thr Glu Leu Pro His 
            20                  25                  30          


Met Val Gly Val Ser Arg Arg Thr Leu Phe Thr Phe His Asp Leu Tyr 
        35                  40                  45              


Phe His Leu Val Glu Ala Asp Glu Asp Ile Thr Pro Asn Leu Tyr Arg 
    50                  55                  60                  


Ala Arg Ser His Pro Leu Tyr Ala Asp Val Asn Lys Arg Leu Gly Glu 
65                  70                  75                  80  


Leu Val Ala Pro Tyr Asp Pro Gly Trp Lys Glu Pro Lys Asp Ala Met 
                85                  90                  95      


Ala Ser Pro Phe Tyr Thr Trp Thr Ala Glu Gln Gly Arg Ile Arg 
            100                 105                 110     


<210>  102
<211>  1032
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(1032)
<223>  ZhuJ-1 gene [GenBank ID number AN5060.2) encoding a Cyclase 
       [GenBank ID number XP_662664.1]

<400>  102
atg tct gaa tac acc aac ctg ccc gac tac gac tcc ctc ccg ccc gtc         48
Met Ser Glu Tyr Thr Asn Leu Pro Asp Tyr Asp Ser Leu Pro Pro Val           
1               5                   10                  15                

aaa ggc atg ccc cgt ggc tgc gca tgg ggt att ttc gac aaa gac ggc         96
Lys Gly Met Pro Arg Gly Cys Ala Trp Gly Ile Phe Asp Lys Asp Gly           
            20                  25                  30                    

aag aaa gac cat atc ggg tgt ctg aac ctg ctt acg ccg tct gtg gtg        144
Lys Lys Asp His Ile Gly Cys Leu Asn Leu Leu Thr Pro Ser Val Val           
        35                  40                  45                        

cgc gcg gcc ttg aag gaa gcg gag acg ggc cag tcg gtc tcg ctg aac        192
Arg Ala Ala Leu Lys Glu Ala Glu Thr Gly Gln Ser Val Ser Leu Asn           
    50                  55                  60                            

tgg ccc atc aac gct atc cat aag cct ggg ttc cag cgc gcg gga ctc        240
Trp Pro Ile Asn Ala Ile His Lys Pro Gly Phe Gln Arg Ala Gly Leu           
65                  70                  75                  80            

gag cat aag gtc tct tcg ttc cag gac acg ccc ttc aag tta cat ggg        288
Glu His Lys Val Ser Ser Phe Gln Asp Thr Pro Phe Lys Leu His Gly           
                85                  90                  95                

ttc gac gac gag gtc gcg ttc aat act cag tgc tcc agc cag tgg gat        336
Phe Asp Asp Glu Val Ala Phe Asn Thr Gln Cys Ser Ser Gln Trp Asp           
            100                 105                 110                   

agc ttg gta cat ttc gcg cac cag ccg tcc ggg ttc agc tat aat gga        384
Ser Leu Val His Phe Ala His Gln Pro Ser Gly Phe Ser Tyr Asn Gly           
        115                 120                 125                       

gtc aag cca acg aag gag gcg ctg ctg cag gca gac gcg ccc ttc cac        432
Val Lys Pro Thr Lys Glu Ala Leu Leu Gln Ala Asp Ala Pro Phe His           
    130                 135                 140                           

aaa gac acc gac ctg ccc acg ctt gac cac tgg cat tcg cgc ggc ggc        480
Lys Asp Thr Asp Leu Pro Thr Leu Asp His Trp His Ser Arg Gly Gly           
145                 150                 155                 160           

ctc gtc ggt cgc ggt gtc ctg ctc gac tac caa gcg tac gca gac gcg        528
Leu Val Gly Arg Gly Val Leu Leu Asp Tyr Gln Ala Tyr Ala Asp Ala           
                165                 170                 175               

cac ggc cgg aag tac tct ccc ttt gag acg cac aaa atc act gtc gcc        576
His Gly Arg Lys Tyr Ser Pro Phe Glu Thr His Lys Ile Thr Val Ala           
            180                 185                 190                   

gat ctc gag gct gtg gct caa tgg gag aat gtt gag ttg cgc cag ggc        624
Asp Leu Glu Ala Val Ala Gln Trp Glu Asn Val Glu Leu Arg Gln Gly           
        195                 200                 205                       

gat att gtc atc atc cgg tcc ggg ttc aca aag ggg ctg cag gaa gct        672
Asp Ile Val Ile Ile Arg Ser Gly Phe Thr Lys Gly Leu Gln Glu Ala           
    210                 215                 220                           

gcc acg cca gag aaa cag gca gag tgc atg gcc agc cac cga act gtc        720
Ala Thr Pro Glu Lys Gln Ala Glu Cys Met Ala Ser His Arg Thr Val           
225                 230                 235                 240           

ggg gtg gaa ggc aac gag gct acg gcg aag tgg ttc tgg aac aag cat        768
Gly Val Glu Gly Asn Glu Ala Thr Ala Lys Trp Phe Trp Asn Lys His           
                245                 250                 255               

ttt gcg gct gtt gcg ggc gat gcc atc gcg ttc gag tgt ctg ccg ccg        816
Phe Ala Ala Val Ala Gly Asp Ala Ile Ala Phe Glu Cys Leu Pro Pro           
            260                 265                 270                   

tcg aaa gaa gat ggg aca gag ggg tcg att gga gat ctg gtg ctg cat        864
Ser Lys Glu Asp Gly Thr Glu Gly Ser Ile Gly Asp Leu Val Leu His           
        275                 280                 285                       

cag tac ttc ctc ggc ctg ttc ggg ctg aat atc ggc gag ctg tgg gat        912
Gln Tyr Phe Leu Gly Leu Phe Gly Leu Asn Ile Gly Glu Leu Trp Asp           
    290                 295                 300                           

ctt gag gcg ctg tcg aag ctt tgt gct gag aag aag cga tac tcg ttc        960
Leu Glu Ala Leu Ser Lys Leu Cys Ala Glu Lys Lys Arg Tyr Ser Phe           
305                 310                 315                 320           

ttg ctc aca agc tgt ccg ctc aac gtg cca ggc agc gtc ggg agc cca       1008
Leu Leu Thr Ser Cys Pro Leu Asn Val Pro Gly Ser Val Gly Ser Pro           
                325                 330                 335               

ccg aat gcg ctt gcg att ttt tag                                       1032
Pro Asn Ala Leu Ala Ile Phe                                               
            340                                                           


<210>  103
<211>  343
<212>  PRT
<213>  Aspergillus nidulans

<400>  103

Met Ser Glu Tyr Thr Asn Leu Pro Asp Tyr Asp Ser Leu Pro Pro Val 
1               5                   10                  15      


Lys Gly Met Pro Arg Gly Cys Ala Trp Gly Ile Phe Asp Lys Asp Gly 
            20                  25                  30          


Lys Lys Asp His Ile Gly Cys Leu Asn Leu Leu Thr Pro Ser Val Val 
        35                  40                  45              


Arg Ala Ala Leu Lys Glu Ala Glu Thr Gly Gln Ser Val Ser Leu Asn 
    50                  55                  60                  


Trp Pro Ile Asn Ala Ile His Lys Pro Gly Phe Gln Arg Ala Gly Leu 
65                  70                  75                  80  


Glu His Lys Val Ser Ser Phe Gln Asp Thr Pro Phe Lys Leu His Gly 
                85                  90                  95      


Phe Asp Asp Glu Val Ala Phe Asn Thr Gln Cys Ser Ser Gln Trp Asp 
            100                 105                 110         


Ser Leu Val His Phe Ala His Gln Pro Ser Gly Phe Ser Tyr Asn Gly 
        115                 120                 125             


Val Lys Pro Thr Lys Glu Ala Leu Leu Gln Ala Asp Ala Pro Phe His 
    130                 135                 140                 


Lys Asp Thr Asp Leu Pro Thr Leu Asp His Trp His Ser Arg Gly Gly 
145                 150                 155                 160 


Leu Val Gly Arg Gly Val Leu Leu Asp Tyr Gln Ala Tyr Ala Asp Ala 
                165                 170                 175     


His Gly Arg Lys Tyr Ser Pro Phe Glu Thr His Lys Ile Thr Val Ala 
            180                 185                 190         


Asp Leu Glu Ala Val Ala Gln Trp Glu Asn Val Glu Leu Arg Gln Gly 
        195                 200                 205             


Asp Ile Val Ile Ile Arg Ser Gly Phe Thr Lys Gly Leu Gln Glu Ala 
    210                 215                 220                 


Ala Thr Pro Glu Lys Gln Ala Glu Cys Met Ala Ser His Arg Thr Val 
225                 230                 235                 240 


Gly Val Glu Gly Asn Glu Ala Thr Ala Lys Trp Phe Trp Asn Lys His 
                245                 250                 255     


Phe Ala Ala Val Ala Gly Asp Ala Ile Ala Phe Glu Cys Leu Pro Pro 
            260                 265                 270         


Ser Lys Glu Asp Gly Thr Glu Gly Ser Ile Gly Asp Leu Val Leu His 
        275                 280                 285             


Gln Tyr Phe Leu Gly Leu Phe Gly Leu Asn Ile Gly Glu Leu Trp Asp 
    290                 295                 300                 


Leu Glu Ala Leu Ser Lys Leu Cys Ala Glu Lys Lys Arg Tyr Ser Phe 
305                 310                 315                 320 


Leu Leu Thr Ser Cys Pro Leu Asn Val Pro Gly Ser Val Gly Ser Pro 
                325                 330                 335     


Pro Asn Ala Leu Ala Ile Phe 
            340             


<210>  104
<211>  1014
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(1014)
<223>  ZhuJ-2 gene [GenBank ID number ANIA_11053) encoding a cyclase 
       [GenBank ID number CBF74060.1]

<400>  104
atg gca ccc ctg cct tct att ccc acc ttc gac aac ctg acc ctc gac         48
Met Ala Pro Leu Pro Ser Ile Pro Thr Phe Asp Asn Leu Thr Leu Asp           
1               5                   10                  15                

ccc aat ggt ccc cct ggc aac gca tgg ggt cta ttt gga cct aat aat         96
Pro Asn Gly Pro Pro Gly Asn Ala Trp Gly Leu Phe Gly Pro Asn Asn           
            20                  25                  30                    

gaa ctt ggg atg ctt aat ttg ctc acc ccc gag gta gtt aag aga gca        144
Glu Leu Gly Met Leu Asn Leu Leu Thr Pro Glu Val Val Lys Arg Ala           
        35                  40                  45                        

gcc tcc gag gaa atc cgc gag ggg gtc cga ata tct ctt gat ctt cct        192
Ala Ser Glu Glu Ile Arg Glu Gly Val Arg Ile Ser Leu Asp Leu Pro           
    50                  55                  60                            

cta aat cga ctc tcg cat ccg agc ttc aac cgg aaa ccc ttc atc caa        240
Leu Asn Arg Leu Ser His Pro Ser Phe Asn Arg Lys Pro Phe Ile Gln           
65                  70                  75                  80            

gag ctg gtt aat aag gca ccg agg att gtc aat gat gat atc ttg acg        288
Glu Leu Val Asn Lys Ala Pro Arg Ile Val Asn Asp Asp Ile Leu Thr           
                85                  90                  95                

ttc aat acg cag tcg agc acg cag tgg gat ggg ttt agg cat tac gga        336
Phe Asn Thr Gln Ser Ser Thr Gln Trp Asp Gly Phe Arg His Tyr Gly           
            100                 105                 110                   

aac cag acg cat ggg tgt tac ttt aat ggc cat tcg ctg gat gag ctg        384
Asn Gln Thr His Gly Cys Tyr Phe Asn Gly His Ser Leu Asp Glu Leu           
        115                 120                 125                       

aga gag tcg agg gtt atc gga att gac gca tgg tcc aac agc ggc ggc        432
Arg Glu Ser Arg Val Ile Gly Ile Asp Ala Trp Ser Asn Ser Gly Gly           
    130                 135                 140                           

att gtc ggc cgg ggc att cta att gat tac gcg acc tgg gcg cag aga        480
Ile Val Gly Arg Gly Ile Leu Ile Asp Tyr Ala Thr Trp Ala Gln Arg           
145                 150                 155                 160           

aac tcc att gcc cta acg ccc ttc caa acg tct aca atc ccc ctc tca        528
Asn Ser Ile Ala Leu Thr Pro Phe Gln Thr Ser Thr Ile Pro Leu Ser           
                165                 170                 175               

tcc att cag cag ata atc cac gaa acc tcc cta acc ccc cgc cca ggc        576
Ser Ile Gln Gln Ile Ile His Glu Thr Ser Leu Thr Pro Arg Pro Gly           
            180                 185                 190                   

gac atc ctc ttc atc cgc aca ggc ttc aca gaa gcc tac aac aag ctc        624
Asp Ile Leu Phe Ile Arg Thr Gly Phe Thr Glu Ala Tyr Asn Lys Leu           
        195                 200                 205                       

acg ccg gac gaa gaa gca gcc att gcc gcg cga cca aca cca aac ttt        672
Thr Pro Asp Glu Glu Ala Ala Ile Ala Ala Arg Pro Thr Pro Asn Phe           
    210                 215                 220                           

gcg ggc gtc gag aac ggc aag aac aca ttg cgc tgg ttg tgg gag aac        720
Ala Gly Val Glu Asn Gly Lys Asn Thr Leu Arg Trp Leu Trp Glu Asn           
225                 230                 235                 240           

cag ttt gcg gca atc gcg agt gac agt cca gct ttt gaa ccg gcg ccg        768
Gln Phe Ala Ala Ile Ala Ser Asp Ser Pro Ala Phe Glu Pro Ala Pro           
                245                 250                 255               

ctg ttt agg ccc gag cag ggg gtt gga cat gag gtg acg ctg cat cag        816
Leu Phe Arg Pro Glu Gln Gly Val Gly His Glu Val Thr Leu His Gln           
            260                 265                 270                   

tgg tgt ctg agt gcg tgg gga atg ccg atc ggg gag tac ttt gat ctg        864
Trp Cys Leu Ser Ala Trp Gly Met Pro Ile Gly Glu Tyr Phe Asp Leu           
        275                 280                 285                       

gaa gag ctt gca aaa tat tgt agg gag aag ggg agg tgg agt ttc ttc        912
Glu Glu Leu Ala Lys Tyr Cys Arg Glu Lys Gly Arg Trp Ser Phe Phe           
    290                 295                 300                           

ttg agc agt att ccg ctt aag gtt tgt tat tta cct ttt tca ttt tat        960
Leu Ser Ser Ile Pro Leu Lys Val Cys Tyr Leu Pro Phe Ser Phe Tyr           
305                 310                 315                 320           

att ttt ttt gtt tct tat ttt gtt ttg ggc tat gta gtt tgc tgc aat       1008
Ile Phe Phe Val Ser Tyr Phe Val Leu Gly Tyr Val Val Cys Cys Asn           
                325                 330                 335               

tgc tga                                                               1014
Cys                                                                       
                                                                          


<210>  105
<211>  337
<212>  PRT
<213>  Aspergillus nidulans

<400>  105

Met Ala Pro Leu Pro Ser Ile Pro Thr Phe Asp Asn Leu Thr Leu Asp 
1               5                   10                  15      


Pro Asn Gly Pro Pro Gly Asn Ala Trp Gly Leu Phe Gly Pro Asn Asn 
            20                  25                  30          


Glu Leu Gly Met Leu Asn Leu Leu Thr Pro Glu Val Val Lys Arg Ala 
        35                  40                  45              


Ala Ser Glu Glu Ile Arg Glu Gly Val Arg Ile Ser Leu Asp Leu Pro 
    50                  55                  60                  


Leu Asn Arg Leu Ser His Pro Ser Phe Asn Arg Lys Pro Phe Ile Gln 
65                  70                  75                  80  


Glu Leu Val Asn Lys Ala Pro Arg Ile Val Asn Asp Asp Ile Leu Thr 
                85                  90                  95      


Phe Asn Thr Gln Ser Ser Thr Gln Trp Asp Gly Phe Arg His Tyr Gly 
            100                 105                 110         


Asn Gln Thr His Gly Cys Tyr Phe Asn Gly His Ser Leu Asp Glu Leu 
        115                 120                 125             


Arg Glu Ser Arg Val Ile Gly Ile Asp Ala Trp Ser Asn Ser Gly Gly 
    130                 135                 140                 


Ile Val Gly Arg Gly Ile Leu Ile Asp Tyr Ala Thr Trp Ala Gln Arg 
145                 150                 155                 160 


Asn Ser Ile Ala Leu Thr Pro Phe Gln Thr Ser Thr Ile Pro Leu Ser 
                165                 170                 175     


Ser Ile Gln Gln Ile Ile His Glu Thr Ser Leu Thr Pro Arg Pro Gly 
            180                 185                 190         


Asp Ile Leu Phe Ile Arg Thr Gly Phe Thr Glu Ala Tyr Asn Lys Leu 
        195                 200                 205             


Thr Pro Asp Glu Glu Ala Ala Ile Ala Ala Arg Pro Thr Pro Asn Phe 
    210                 215                 220                 


Ala Gly Val Glu Asn Gly Lys Asn Thr Leu Arg Trp Leu Trp Glu Asn 
225                 230                 235                 240 


Gln Phe Ala Ala Ile Ala Ser Asp Ser Pro Ala Phe Glu Pro Ala Pro 
                245                 250                 255     


Leu Phe Arg Pro Glu Gln Gly Val Gly His Glu Val Thr Leu His Gln 
            260                 265                 270         


Trp Cys Leu Ser Ala Trp Gly Met Pro Ile Gly Glu Tyr Phe Asp Leu 
        275                 280                 285             


Glu Glu Leu Ala Lys Tyr Cys Arg Glu Lys Gly Arg Trp Ser Phe Phe 
    290                 295                 300                 


Leu Ser Ser Ile Pro Leu Lys Val Cys Tyr Leu Pro Phe Ser Phe Tyr 
305                 310                 315                 320 


Ile Phe Phe Val Ser Tyr Phe Val Leu Gly Tyr Val Val Cys Cys Asn 
                325                 330                 335     


Cys 
    


<210>  106
<211>  975
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(975)
<223>  ZhuJ-3 gene [GenBank ID number ANIA_10146) encoding cyclase 
       [GenBank ID number CBF88175.1]

<400>  106
atg act act ttc gac cta cca gag aca ttt gat gac ctc ccc aac aag         48
Met Thr Thr Phe Asp Leu Pro Glu Thr Phe Asp Asp Leu Pro Asn Lys           
1               5                   10                  15                

cgc caa tac tgg cct gct ccg aaa ggc tcg ccc gaa gag ggc cta ggc         96
Arg Gln Tyr Trp Pro Ala Pro Lys Gly Ser Pro Glu Glu Gly Leu Gly           
            20                  25                  30                    

atg ctc cgt atc ctg acc ccg gac atc gtt gcc aat gca gcc cgc caa        144
Met Leu Arg Ile Leu Thr Pro Asp Ile Val Ala Asn Ala Ala Arg Gln           
        35                  40                  45                        

atc caa acg ggc gag cgg gta tgt ctg aac tgg gat att gag aac ttg        192
Ile Gln Thr Gly Glu Arg Val Cys Leu Asn Trp Asp Ile Glu Asn Leu           
    50                  55                  60                            

aat cct cca ggt ttc aaa cgc aag ccc ttt gag cac agg ata aaa tgg        240
Asn Pro Pro Gly Phe Lys Arg Lys Pro Phe Glu His Arg Ile Lys Trp           
65                  70                  75                  80            

gtc gca gaa ggc gtg gct ttt gat gac gaa tat cac ttc aat cca cag        288
Val Ala Glu Gly Val Ala Phe Asp Asp Glu Tyr His Phe Asn Pro Gln           
                85                  90                  95                

cag tca tct caa tgg gac ggc ctc cgt cac cac aat ggg ccc gca cca        336
Gln Ser Ser Gln Trp Asp Gly Leu Arg His His Asn Gly Pro Ala Pro           
            100                 105                 110                   

acg gcc gaa gat ccc aac tgc cga ctt ttc tac gga gga acg agc gca        384
Thr Ala Glu Asp Pro Asn Cys Arg Leu Phe Tyr Gly Gly Thr Ser Ala           
        115                 120                 125                       

gaa gaa att caa gac cct aag aat ccc cgt atc gga atg ggg tac tgg        432
Glu Glu Ile Gln Asp Pro Lys Asn Pro Arg Ile Gly Met Gly Tyr Trp           
    130                 135                 140                           

gcg aag aag ggc att gca gga cgc ggc gtc ctt atc gat ttc gtc tcg        480
Ala Lys Lys Gly Ile Ala Gly Arg Gly Val Leu Ile Asp Phe Val Ser           
145                 150                 155                 160           

tgg gct gaa aag aag gga atc ccc gtc aat gcc tta aca cag cag gag        528
Trp Ala Glu Lys Lys Gly Ile Pro Val Asn Ala Leu Thr Gln Gln Glu           
                165                 170                 175               

gtt tca cta gac act gtg cac gag att gcg cga gag tgc aag gtt gaa        576
Val Ser Leu Asp Thr Val His Glu Ile Ala Arg Glu Cys Lys Val Glu           
            180                 185                 190                   

ttc caa cac ggc gac atc ttc ttc ctc aga gtc ggt ctg ccg caa aca        624
Phe Gln His Gly Asp Ile Phe Phe Leu Arg Val Gly Leu Pro Gln Thr           
        195                 200                 205                       

tgg gcg gcc atg aac gat gag cag aaa caa gcg tac agc aag cag gcg        672
Trp Ala Ala Met Asn Asp Glu Gln Lys Gln Ala Tyr Ser Lys Gln Ala           
    210                 215                 220                           

acc cca aaa cat gcc ggg atc gag caa agt gag cgt gtg cta cgg ttc        720
Thr Pro Lys His Ala Gly Ile Glu Gln Ser Glu Arg Val Leu Arg Phe           
225                 230                 235                 240           

ttt tgg gac aac cac ttt gcg gcg gtt gcg tca gac gcg gtc agt ttc        768
Phe Trp Asp Asn His Phe Ala Ala Val Ala Ser Asp Ala Val Ser Phe           
                245                 250                 255               

gag gtg tac cca cca ctt aac ccg gac ttt gat ctg cat cat cat cta        816
Glu Val Tyr Pro Pro Leu Asn Pro Asp Phe Asp Leu His His His Leu           
            260                 265                 270                   

ctt gcg ggg tgg gga gta cct atc ggc gag atg ttt gat ttg gat ggg        864
Leu Ala Gly Trp Gly Val Pro Ile Gly Glu Met Phe Asp Leu Asp Gly           
        275                 280                 285                       

ttg gcg gag atg tgt ata caa cat ggt cgc tgg acg ttt ttc gtc tcg        912
Leu Ala Glu Met Cys Ile Gln His Gly Arg Trp Thr Phe Phe Val Ser           
    290                 295                 300                           

agt agc cct ttg aac tgt gcg aat ggg gtc tcg agt ccc ccg aac act        960
Ser Ser Pro Leu Asn Cys Ala Asn Gly Val Ser Ser Pro Pro Asn Thr           
305                 310                 315                 320           

atg gct att ttt tga                                                    975
Met Ala Ile Phe                                                           
                                                                          


<210>  107
<211>  324
<212>  PRT
<213>  Aspergillus nidulans

<400>  107

Met Thr Thr Phe Asp Leu Pro Glu Thr Phe Asp Asp Leu Pro Asn Lys 
1               5                   10                  15      


Arg Gln Tyr Trp Pro Ala Pro Lys Gly Ser Pro Glu Glu Gly Leu Gly 
            20                  25                  30          


Met Leu Arg Ile Leu Thr Pro Asp Ile Val Ala Asn Ala Ala Arg Gln 
        35                  40                  45              


Ile Gln Thr Gly Glu Arg Val Cys Leu Asn Trp Asp Ile Glu Asn Leu 
    50                  55                  60                  


Asn Pro Pro Gly Phe Lys Arg Lys Pro Phe Glu His Arg Ile Lys Trp 
65                  70                  75                  80  


Val Ala Glu Gly Val Ala Phe Asp Asp Glu Tyr His Phe Asn Pro Gln 
                85                  90                  95      


Gln Ser Ser Gln Trp Asp Gly Leu Arg His His Asn Gly Pro Ala Pro 
            100                 105                 110         


Thr Ala Glu Asp Pro Asn Cys Arg Leu Phe Tyr Gly Gly Thr Ser Ala 
        115                 120                 125             


Glu Glu Ile Gln Asp Pro Lys Asn Pro Arg Ile Gly Met Gly Tyr Trp 
    130                 135                 140                 


Ala Lys Lys Gly Ile Ala Gly Arg Gly Val Leu Ile Asp Phe Val Ser 
145                 150                 155                 160 


Trp Ala Glu Lys Lys Gly Ile Pro Val Asn Ala Leu Thr Gln Gln Glu 
                165                 170                 175     


Val Ser Leu Asp Thr Val His Glu Ile Ala Arg Glu Cys Lys Val Glu 
            180                 185                 190         


Phe Gln His Gly Asp Ile Phe Phe Leu Arg Val Gly Leu Pro Gln Thr 
        195                 200                 205             


Trp Ala Ala Met Asn Asp Glu Gln Lys Gln Ala Tyr Ser Lys Gln Ala 
    210                 215                 220                 


Thr Pro Lys His Ala Gly Ile Glu Gln Ser Glu Arg Val Leu Arg Phe 
225                 230                 235                 240 


Phe Trp Asp Asn His Phe Ala Ala Val Ala Ser Asp Ala Val Ser Phe 
                245                 250                 255     


Glu Val Tyr Pro Pro Leu Asn Pro Asp Phe Asp Leu His His His Leu 
            260                 265                 270         


Leu Ala Gly Trp Gly Val Pro Ile Gly Glu Met Phe Asp Leu Asp Gly 
        275                 280                 285             


Leu Ala Glu Met Cys Ile Gln His Gly Arg Trp Thr Phe Phe Val Ser 
    290                 295                 300                 


Ser Ser Pro Leu Asn Cys Ala Asn Gly Val Ser Ser Pro Pro Asn Thr 
305                 310                 315                 320 


Met Ala Ile Phe 
                


<210>  108
<211>  1044
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  CDS
<222>  (1)..(1044)
<223>  ZhuJ-4 gene [GenBank ID number AN5068.2) encoding cyclase [ 
       GenBank ID number XP_662672.1]

<400>  108
atg gca gac agc aag ttg tcc cag tcg ccc tac gac att ccc tat gat         48
Met Ala Asp Ser Lys Leu Ser Gln Ser Pro Tyr Asp Ile Pro Tyr Asp           
1               5                   10                  15                

gag cta gcc aac ccc aga cag gtg tgg gta gga gag ccc gga agc gaa         96
Glu Leu Ala Asn Pro Arg Gln Val Trp Val Gly Glu Pro Gly Ser Glu           
            20                  25                  30                    

gag gaa gga aag gca aag ctc ggc atg ctg acc cca gag gtg gtt cac        144
Glu Glu Gly Lys Ala Lys Leu Gly Met Leu Thr Pro Glu Val Val His           
        35                  40                  45                        

ggg gcg gca gcg tcc gaa att cgg act ggc cgt cgc gtt acc atg ggg        192
Gly Ala Ala Ala Ser Glu Ile Arg Thr Gly Arg Arg Val Thr Met Gly           
    50                  55                  60                            

tgg aca ttg acg gaa ttg ggg tat ccc aat ctc ggt cga cag ccg tgt        240
Trp Thr Leu Thr Glu Leu Gly Tyr Pro Asn Leu Gly Arg Gln Pro Cys           
65                  70                  75                  80            

aaa cat cga atc gtg cca ctg cta gac ggt ttg gcg ttc gat gac tat        288
Lys His Arg Ile Val Pro Leu Leu Asp Gly Leu Ala Phe Asp Asp Tyr           
                85                  90                  95                

tac gaa ttc aat ccg caa cag agt agc caa tgg gac ggg ctt cga cat        336
Tyr Glu Phe Asn Pro Gln Gln Ser Ser Gln Trp Asp Gly Leu Arg His           
            100                 105                 110                   

ttt tcc cag acc gtt cct gga cag agc gag cgt gtc ttc tat ggc ggt        384
Phe Ser Gln Thr Val Pro Gly Gln Ser Glu Arg Val Phe Tyr Gly Gly           
        115                 120                 125                       

aca aca gct gcc gag atc tac gat cgg aag aat gac cgc atc ggc atg        432
Thr Thr Ala Ala Glu Ile Tyr Asp Arg Lys Asn Asp Arg Ile Gly Met           
    130                 135                 140                           

cag cat tgg gcc aag gaa ggc att gca ggc cgc ggc gtc ttg att gac        480
Gln His Trp Ala Lys Glu Gly Ile Ala Gly Arg Gly Val Leu Ile Asp           
145                 150                 155                 160           

tac gcc agt tgg gcg aag aag aaa ggg atc aag tac agc acc ttc tcg        528
Tyr Ala Ser Trp Ala Lys Lys Lys Gly Ile Lys Tyr Ser Thr Phe Ser           
                165                 170                 175               

acc cat caa gtc cgc ctg tcg gat ata cag gag att gcc aaa gaa tgc        576
Thr His Gln Val Arg Leu Ser Asp Ile Gln Glu Ile Ala Lys Glu Cys           
            180                 185                 190                   

gag att gaa ttc aag aag ggc gat atc cta ttt gtg cgg att ggg gtt        624
Glu Ile Glu Phe Lys Lys Gly Asp Ile Leu Phe Val Arg Ile Gly Val           
        195                 200                 205                       

acc gaa gaa tgg gat act atg acg gag gcc cag aag caa gag tat tcc        672
Thr Glu Glu Trp Asp Thr Met Thr Glu Ala Gln Lys Gln Glu Tyr Ser           
    210                 215                 220                           

aac aac agc aaa ccc tta cac gcc ggc gtg gaa gcc acc gag gat atg        720
Asn Asn Ser Lys Pro Leu His Ala Gly Val Glu Ala Thr Glu Asp Met           
225                 230                 235                 240           

ctg cgg tgg cta tgg aat gag aaa ttc gct gcg att gcc agt gac gct        768
Leu Arg Trp Leu Trp Asn Glu Lys Phe Ala Ala Ile Ala Ser Asp Ala           
                245                 250                 255               

atc agt tgg gag gtt tat ccg cct cag tcc gat att ttc ctg cat gag        816
Ile Ser Trp Glu Val Tyr Pro Pro Gln Ser Asp Ile Phe Leu His Glu           
            260                 265                 270                   

tac gtt ctg gct gga tgg gga atg cca att ggc gaa ctt ttc gat ctg        864
Tyr Val Leu Ala Gly Trp Gly Met Pro Ile Gly Glu Leu Phe Asp Leu           
        275                 280                 285                       

gaa gct cta gct cga atg tgc att gaa cac aag cgc tgg agc ttc ttc        912
Glu Ala Leu Ala Arg Met Cys Ile Glu His Lys Arg Trp Ser Phe Phe           
    290                 295                 300                           

gta gcg tcg att cca ctc aac atg cca ggg gtg ccc gcc aca ccc aaa        960
Val Ala Ser Ile Pro Leu Asn Met Pro Gly Val Pro Ala Thr Pro Lys           
305                 310                 315                 320           

gct cct gaa gtg ctt gac cag agc aac atc agc aag ttt cag cac gcc       1008
Ala Pro Glu Val Leu Asp Gln Ser Asn Ile Ser Lys Phe Gln His Ala           
                325                 330                 335               

tcg atc gtg atg gat gta ttt gaa acc aga gga tag                       1044
Ser Ile Val Met Asp Val Phe Glu Thr Arg Gly                               
            340                 345                                       


<210>  109
<211>  347
<212>  PRT
<213>  Aspergillus nidulans

<400>  109

Met Ala Asp Ser Lys Leu Ser Gln Ser Pro Tyr Asp Ile Pro Tyr Asp 
1               5                   10                  15      


Glu Leu Ala Asn Pro Arg Gln Val Trp Val Gly Glu Pro Gly Ser Glu 
            20                  25                  30          


Glu Glu Gly Lys Ala Lys Leu Gly Met Leu Thr Pro Glu Val Val His 
        35                  40                  45              


Gly Ala Ala Ala Ser Glu Ile Arg Thr Gly Arg Arg Val Thr Met Gly 
    50                  55                  60                  


Trp Thr Leu Thr Glu Leu Gly Tyr Pro Asn Leu Gly Arg Gln Pro Cys 
65                  70                  75                  80  


Lys His Arg Ile Val Pro Leu Leu Asp Gly Leu Ala Phe Asp Asp Tyr 
                85                  90                  95      


Tyr Glu Phe Asn Pro Gln Gln Ser Ser Gln Trp Asp Gly Leu Arg His 
            100                 105                 110         


Phe Ser Gln Thr Val Pro Gly Gln Ser Glu Arg Val Phe Tyr Gly Gly 
        115                 120                 125             


Thr Thr Ala Ala Glu Ile Tyr Asp Arg Lys Asn Asp Arg Ile Gly Met 
    130                 135                 140                 


Gln His Trp Ala Lys Glu Gly Ile Ala Gly Arg Gly Val Leu Ile Asp 
145                 150                 155                 160 


Tyr Ala Ser Trp Ala Lys Lys Lys Gly Ile Lys Tyr Ser Thr Phe Ser 
                165                 170                 175     


Thr His Gln Val Arg Leu Ser Asp Ile Gln Glu Ile Ala Lys Glu Cys 
            180                 185                 190         


Glu Ile Glu Phe Lys Lys Gly Asp Ile Leu Phe Val Arg Ile Gly Val 
        195                 200                 205             


Thr Glu Glu Trp Asp Thr Met Thr Glu Ala Gln Lys Gln Glu Tyr Ser 
    210                 215                 220                 


Asn Asn Ser Lys Pro Leu His Ala Gly Val Glu Ala Thr Glu Asp Met 
225                 230                 235                 240 


Leu Arg Trp Leu Trp Asn Glu Lys Phe Ala Ala Ile Ala Ser Asp Ala 
                245                 250                 255     


Ile Ser Trp Glu Val Tyr Pro Pro Gln Ser Asp Ile Phe Leu His Glu 
            260                 265                 270         


Tyr Val Leu Ala Gly Trp Gly Met Pro Ile Gly Glu Leu Phe Asp Leu 
        275                 280                 285             


Glu Ala Leu Ala Arg Met Cys Ile Glu His Lys Arg Trp Ser Phe Phe 
    290                 295                 300                 


Val Ala Ser Ile Pro Leu Asn Met Pro Gly Val Pro Ala Thr Pro Lys 
305                 310                 315                 320 


Ala Pro Glu Val Leu Asp Gln Ser Asn Ile Ser Lys Phe Gln His Ala 
                325                 330                 335     


Ser Ile Val Met Asp Val Phe Glu Thr Arg Gly 
            340                 345         


<210>  110
<211>  42
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(42)
<223>  Sc_Gh_2-PS-F

<400>  110
atcaacgggu aaaaatgggt tcctactctt ctgatgatgt tg                          42


<210>  111
<211>  40
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(40)
<223>  Sc_Gh_2-PS-R primer

<400>  111
cgtgcgautt agttaccatt agcaacagca gcagtaactc                             40


<210>  112
<211>  42
<212>  DNA
<213>  Aloe arborescens


<220>
<221>  primer_bind
<222>  (1)..(42)
<223>  Sc_AaOKS-F primer

<400>  112
atcaacgggd uaaaaatgag tagtttatca aatgccagtc ac                          42


<210>  113
<211>  37
<212>  DNA
<213>  Aloe arborescens


<220>
<221>  primer_bind
<222>  (1)..(37)
<223>  Sc_AaOKS-R primer

<400>  113
cgtgcgadut tacatcaatg gcaaggaatg caataag                                37


<210>  114
<211>  39
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(39)
<223>  Sc_Aa_PCS-F

<400>  114
atcaacgggu aaaaatgtcc tccttgtcta attccttgc                              39


<210>  115
<211>  31
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(31)
<223>  Sc_Aa_PCS-R primer

<400>  115
cgtgcgautt acatcaaagg caaagaatgc a                                      31


<210>  116
<211>  38
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(38)
<223>  Sc_DluHKS-F primer

<400>  116
atcaacgggu aaaaatggct ttcgttgaag gtatgggt                               38


<210>  117
<211>  37
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(37)
<223>  Sc_DluHKS-R

<400>  117
cgtgcgautt agttgttgat tgggaaggat ctcaaga                                37


<210>  118
<211>  41
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(41)
<223>  Sc_AaPKS3/ALS-F

<400>  118
atcaacgggu aaaaatgggt tccttgtctg attctactcc a                           41


<210>  119
<211>  34
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(34)
<223>  Sc_AaPKS3/ALS-R primer

<400>  119
cgtgcgautt agactggtgg caaagaatgc aaca                                   34


<210>  120
<211>  33
<212>  DNA
<213>  Saccharomyces cerevisiae


<220>
<221>  primer_bind
<222>  (1)..(33)
<223>  PGK1-d primer (Phosphoglycerate kinase 1 gene)

<400>  120
acccgttgad ugccgcttgt tttatatttg ttg                                    33


<210>  121
<211>  30
<212>  DNA
<213>  Saccharomyces cerevisiae


<220>
<221>  primer_bind
<222>  (1)..(30)
<223>  PGK1-F primer (Phosphoglycerate kinase 1 gene)

<400>  121
cacgcgadug gcctggaagt accttcaaag                                        30


<210>  122
<211>  42
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(42)
<223>  Sc_ZhuI-F primer

<400>  122
agcgatacgu aaaaatgaga cacgttgaac acacagttac cg                          42


<210>  123
<211>  37
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(37)
<223>  Sc_ZhuI-R primer

<400>  123
cacgcgautt attatgcagt tacggtacca acaccac                                37


<210>  124
<211>  39
<212>  DNA
<213>  Fusarium graminearum


<220>
<221>  primer_bind
<222>  (1)..(39)
<223>  Sc_BIK1-PT-F primer - Fusarium graminearum BIK1 gene

<400>  124
agcgatacgu aaaaatgaga ttgtccgatt ccgttcaca                              39


<210>  125
<211>  37
<212>  DNA
<213>  Fusarium graminearum


<220>
<221>  primer_bind
<222>  (1)..(37)
<223>  Sc_BIK1-PT-R primer from Fusarium graminearum BIK1gene

<400>  125
cacgcgautt aaatcaaacc agaagctgaa ccaactg                                37


<210>  126
<211>  36
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(36)
<223>  Sc_gra-orf4-F primer

<400>  126
agcgatacgu aaaaatggct agaactgctg ctttgc                                 36


<210>  127
<211>  32
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(32)
<223>  Sc_gra-orf4-R primer

<400>  127
cacgcgautt aacctgcttc agcagcttca gc                                     32


<210>  128
<211>  47
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(47)
<223>  Sc_ZhuJ-F primer

<400>  128
agcgatacgu aaaaatgtcc ggtagaaaga cctttttaga tttgtca                     47


<210>  129
<211>  41
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(41)
<223>  Sc_ZhuJ-R primer

<400>  129
cacgcgautt attaatcttc ttcttcttgt tcgaaaacag c                           41


<210>  130
<211>  36
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(36)
<223>  OKS-Forward

<400>  130
ggcttaauat gagttcactc tccaacgctt cccatc                                 36


<210>  131
<211>  41
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(41)
<223>  OKS-Reverse primer

<400>  131
ggtttaautt acatgagagg caggctgtgg agaaggatag t                           41


<210>  132
<211>  26
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  ZhuI-Forward primer

<400>  132
ggcttaauat gaggcatgtc gagcat                                            26


<210>  133
<211>  31
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(31)
<223>  ZhuI-Reverse primer

<400>  133
ggtttaautt atgccgtgac agttccgaca c                                      31


<210>  134
<211>  26
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  ZhuJ-Forward primer

<400>  134
ggcttaauat gtccggacgt aagacg                                            26


<210>  135
<211>  31
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(31)
<223>  ZhuJ-Reverse primer

<400>  135
ggtttaautt aatcttcctc ctcctgttca a                                      31


<210>  136
<211>  26
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  CYC-Forward primer

<400>  136
ggcttaauat gactgttgaa gttcgt                                            26


<210>  137
<211>  31
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(31)

<400>  137
ggtttaautt aagccaagca agtaggaagt t                                      31


<210>  138
<211>  26
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  CYC_DH-Forward primer

<400>  138
ggcttaauat gtcaagacct ggagaa                                            26


<210>  139
<211>  26
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(26)
<223>  CYC_DH-Reverse primer

<400>  139
ggtttaautt agcttgccgg cccagc                                            26


<210>  140
<211>  36
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(36)
<223>  KR-Forward primer

<400>  140
ggcttaauat ggcaacccag gatagcgaag ttgcac                                 36


<210>  141
<211>  41
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(41)
<223>  KR-Reverse

<400>  141
ggtttaautt aatagttgcc cagaccacca caaacattca g                           41


<210>  142
<211>  29
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(29)
<223>  HpPKS2-Forward primer

<400>  142
ggcttaauat gggttccctt gacaatggt                                         29


<210>  143
<211>  31
<212>  DNA
<213>  synthetic


<220>
<221>  primer_bind
<222>  (1)..(31)
<223>  HpPKS2-Reverse primer

<400>  143
ggtttaautt agagaggcac acttcggaga a                                      31


<210>  144
<211>  39
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  primer_bind
<222>  (1)..(39)
<223>  Sc_mdpG-PT-F primer from Aspergillus nidulans mdpG-PT gene

<400>  144
agcgatacgu aaaaatgtct ggtttgagaa cttccaccg                              39


<210>  145
<211>  36
<212>  DNA
<213>  Aspergillus nidulans


<220>
<221>  primer_bind
<222>  (1)..(36)
<223>  Sc_mdpG-PT-R primer from Aspergillus nidulans mdpG-PT gene

<400>  145
cacgcgautt agaccaaagc tttagcagca actgaa                                 36


