                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
       Bolt, Gert
       Karpf , Ditte Maria
       Nrby , Peder Lisby
 
<120>  FVIII FUSION PROTEINS

<130>  150022WO01

<150>  15171338.5
<151>  2015-06-10

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  2332
<212>  PRT
<213>  homo sapiens

<400>  1

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  2
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  2

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn Pro Pro Val Leu 
1               5                   10                  15      


Lys Arg His Gln Arg 
            20      


<210>  3
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  3

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn Pro Pro Val Leu 
1               5                   10                  15      


Lys Arg His Gln 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  4

Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn Pro Pro Val Leu Lys 
1               5                   10                  15      


Arg His Gln Arg 
            20  


<210>  5
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  5

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr 
            20                  25                  


<210>  6
<211>  54
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  6

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu 
    50                  


<210>  7
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  7

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu 
        115         


<210>  8
<211>  163
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  8

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser 
            


<210>  9
<211>  174
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  9

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp 
                165                 170                 


<210>  10
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  10

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn 
    210                 


<210>  11
<211>  226
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  11

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser 
225     


<210>  12
<211>  228
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  12

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu 
225             


<210>  13
<211>  263
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  13

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr 
            260             


<210>  14
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  14

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr 
            260                 265                 


<210>  15
<211>  278
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  15

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro 
        275             


<210>  16
<211>  280
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  16

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu 
        275                 280 


<210>  17
<211>  330
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  17

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser 
                325                 330 


<210>  18
<211>  339
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  18

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln 
            


<210>  19
<211>  466
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  19

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln 
465     


<210>  20
<211>  490
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  20

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu 
                485                 490 


<210>  21
<211>  521
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  21

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr 
        515                 520     


<210>  22
<211>  561
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  22

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr 
    


<210>  23
<211>  569
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  23

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln 
                565                 


<210>  24
<211>  646
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  24

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser 
                645     


<210>  25
<211>  655
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  25

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser 
                645                 650                 655 


<210>  26
<211>  704
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  26

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


<210>  27
<211>  700
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  27

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys 
    690                 695                 700 


<210>  28
<211>  721
<212>  PRT
<213>  artificial

<220>
<223>  Syntetic

<400>  28

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser 
    


<210>  29
<211>  774
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  29

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser 
    770                 


<210>  30
<211>  784
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  30

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser 
    770                 775                 780                 


<210>  31
<211>  813
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  31

Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe Asn 
1               5                   10                  15      


Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp Phe 
            20                  25                  30          


Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser Asp 
        35                  40                  45              


Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser Leu 
    50                  55                  60                  


Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro Ser 
65                  70                  75                  80  


Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His Phe 
                85                  90                  95      


Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu Ser 
            100                 105                 110         


Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala Thr 
        115                 120                 125             


Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn Leu 
    130                 135                 140                 


Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn Thr 
145                 150                 155                 160 


Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln Leu 
                165                 170                 175     


Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser Gly 
            180                 185                 190         


Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu Glu 
        195                 200                 205             


Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val Ser 
    210                 215                 220                 


Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly Pro 
225                 230                 235                 240 


Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser Leu 
                245                 250                 255     


Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys Thr 
            260                 265                 270         


His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val Trp 
        275                 280                 285             


Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro Leu 
    290                 295                 300                 


Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg Leu 
305                 310                 315                 320 


Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met Val 
                325                 330                 335     


Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro Asp 
            340                 345                 350         


Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp Ile 
        355                 360                 365             


Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro Ser 
    370                 375                 380                 


Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly Gln 
385                 390                 395                 400 


Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu Phe 
                405                 410                 415     


Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg Asn 
            420                 425                 430         


Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His Asn 
        435                 440                 445             


Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu Ile 
    450                 455                 460                 


Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr Lys 
465                 470                 475                 480 


Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val Glu 
                485                 490                 495     


Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg Ser 
            500                 505                 510         


Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe Ser 
        515                 520                 525             


Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr Lys 
    530                 535                 540                 


Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn Thr 
545                 550                 555                 560 


Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys Gln 
                565                 570                 575     


Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile Val 
            580                 585                 590         


Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr Pro 
        595                 600                 605             


Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala Ile 
    610                 615                 620                 


Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile Pro 
625                 630                 635                 640 


Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe Pro 
                645                 650                 655     


Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn Ser 
            660                 665                 670         


Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val Gln 
        675                 680                 685             


Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser Leu 
    690                 695                 700                 


Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly Ser 
705                 710                 715                 720 


Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu Asn 
                725                 730                 735     


Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val Glu 
            740                 745                 750         


Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr Glu 
        755                 760                 765             


Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser Leu 
    770                 775                 780                 


Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg Pro 
785                 790                 795                 800 


Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu Ser Ser 
                805                 810             


<210>  32
<211>  855
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  32

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser 
    770                 775                 780                 


Leu Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg 
785                 790                 795                 800 


Pro Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu Ser Ser Ala Lys 
                805                 810                 815     


Thr Pro Ser Lys Leu Leu Asp Pro Leu Ala Trp Asp Asn His Tyr Gly 
            820                 825                 830         


Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu 
        835                 840                 845             


Lys Thr Ala Phe Lys Lys Lys 
    850                 855 


<210>  33
<211>  903
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  33

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser 
    770                 775                 780                 


Leu Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg 
785                 790                 795                 800 


Pro Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu Ser Ser Ala Lys 
                805                 810                 815     


Thr Pro Ser Lys Leu Leu Asp Pro Leu Ala Trp Asp Asn His Tyr Gly 
            820                 825                 830         


Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu 
        835                 840                 845             


Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys 
    850                 855                 860                 


Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu Gly Gln Asn Lys Pro 
865                 870                 875                 880 


Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg Thr Glu Arg Leu Cys 
                885                 890                 895     


Ser Gln Asn Pro Pro Val Leu 
            900             


<210>  34
<211>  908
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  34

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Thr Asp Pro Trp 
            20                  25                  30          


Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe Ser Asp Asp Pro 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser Glu Met Thr His 
                85                  90                  95      


Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly Thr Thr Ala Ala 
        115                 120                 125             


Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser Thr Ser Asn Asn 
    130                 135                 140                 


Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr Asp Asn 
145                 150                 155                 160 


Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His Tyr Asp Ser Gln 
                165                 170                 175     


Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro Leu Thr Glu Ser 
            180                 185                 190         


Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp Ser Lys Leu Leu 
        195                 200                 205             


Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp Gly Lys Asn Val 
    210                 215                 220                 


Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys Arg Ala His Gly 
225                 230                 235                 240 


Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Ser Ile Ser 
                245                 250                 255     


Leu Leu Lys Thr Asn Lys Thr Ser Asn Asn Ser Ala Thr Asn Arg Lys 
            260                 265                 270         


Thr His Ile Asp Gly Pro Ser Leu Leu Ile Glu Asn Ser Pro Ser Val 
        275                 280                 285             


Trp Gln Asn Ile Leu Glu Ser Asp Thr Glu Phe Lys Lys Val Thr Pro 
    290                 295                 300                 


Leu Ile His Asp Arg Met Leu Met Asp Lys Asn Ala Thr Ala Leu Arg 
305                 310                 315                 320 


Leu Asn His Met Ser Asn Lys Thr Thr Ser Ser Lys Asn Met Glu Met 
                325                 330                 335     


Val Gln Gln Lys Lys Glu Gly Pro Ile Pro Pro Asp Ala Gln Asn Pro 
            340                 345                 350         


Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Arg Trp 
        355                 360                 365             


Ile Gln Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln Gly Pro 
    370                 375                 380                 


Ser Pro Lys Gln Leu Val Ser Leu Gly Pro Glu Lys Ser Val Glu Gly 
385                 390                 395                 400 


Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Lys Gly Glu 
                405                 410                 415     


Phe Thr Lys Asp Val Gly Leu Lys Glu Met Val Phe Pro Ser Ser Arg 
            420                 425                 430         


Asn Leu Phe Leu Thr Asn Leu Asp Asn Leu His Glu Asn Asn Thr His 
        435                 440                 445             


Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Lys Lys Glu Thr Leu 
    450                 455                 460                 


Ile Gln Glu Asn Val Val Leu Pro Gln Ile His Thr Val Thr Gly Thr 
465                 470                 475                 480 


Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln Asn Val 
                485                 490                 495     


Glu Gly Ser Tyr Asp Gly Ala Tyr Ala Pro Val Leu Gln Asp Phe Arg 
            500                 505                 510         


Ser Leu Asn Asp Ser Thr Asn Arg Thr Lys Lys His Thr Ala His Phe 
        515                 520                 525             


Ser Lys Lys Gly Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn Gln Thr 
    530                 535                 540                 


Lys Gln Ile Val Glu Lys Tyr Ala Cys Thr Thr Arg Ile Ser Pro Asn 
545                 550                 555                 560 


Thr Ser Gln Gln Asn Phe Val Thr Gln Arg Ser Lys Arg Ala Leu Lys 
                565                 570                 575     


Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Arg Ile Ile 
            580                 585                 590         


Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys His Leu Thr 
        595                 600                 605             


Pro Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys Gly Ala 
    610                 615                 620                 


Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Thr Arg Ser His Ser Ile 
625                 630                 635                 640 


Pro Gln Ala Asn Arg Ser Pro Leu Pro Ile Ala Lys Val Ser Ser Phe 
                645                 650                 655     


Pro Ser Ile Arg Pro Ile Tyr Leu Thr Arg Val Leu Phe Gln Asp Asn 
            660                 665                 670         


Ser Ser His Leu Pro Ala Ala Ser Tyr Arg Lys Lys Asp Ser Gly Val 
        675                 680                 685             


Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Lys Asn Asn Leu Ser 
    690                 695                 700                 


Leu Ala Ile Leu Thr Leu Glu Met Thr Gly Asp Gln Arg Glu Val Gly 
705                 710                 715                 720 


Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Thr Tyr Lys Lys Val Glu 
                725                 730                 735     


Asn Thr Val Leu Pro Lys Pro Asp Leu Pro Lys Thr Ser Gly Lys Val 
            740                 745                 750         


Glu Leu Leu Pro Lys Val His Ile Tyr Gln Lys Asp Leu Phe Pro Thr 
        755                 760                 765             


Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Val Glu Gly Ser 
    770                 775                 780                 


Leu Leu Gln Gly Thr Glu Gly Ala Ile Lys Trp Asn Glu Ala Asn Arg 
785                 790                 795                 800 


Pro Gly Lys Val Pro Phe Leu Arg Val Ala Thr Glu Ser Ser Ala Lys 
                805                 810                 815     


Thr Pro Ser Lys Leu Leu Asp Pro Leu Ala Trp Asp Asn His Tyr Gly 
            820                 825                 830         


Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser Pro Glu 
        835                 840                 845             


Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu Ser Leu Asn Ala Cys 
    850                 855                 860                 


Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu Gly Gln Asn Lys Pro 
865                 870                 875                 880 


Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg Thr Glu Arg Leu Cys 
                885                 890                 895     


Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg 
            900                 905             


<210>  35
<211>  1672
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  35

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu 
        755                 760                 765             


Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu 
    770                 775                 780                 


Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 
785                 790                 795                 800 


Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
                805                 810                 815     


Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
            820                 825                 830         


Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
        835                 840                 845             


Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
    850                 855                 860                 


Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
865                 870                 875                 880 


Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
                885                 890                 895     


Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
            900                 905                 910         


Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
        915                 920                 925             


Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
    930                 935                 940                 


Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
945                 950                 955                 960 


His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
                965                 970                 975     


Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
            980                 985                 990         


Phe Thr Ile Phe Asp Glu Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met 
        995                 1000                 1005             


Glu Arg  Asn Cys Arg Ala Pro  Cys Asn Ile Gln Met  Glu Asp Pro 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Ile 
    1025                 1030                 1035             


Met Asp  Thr Leu Pro Gly Leu  Val Met Ala Gln Asp  Gln Arg Ile 
    1040                 1045                 1050             


Arg Trp  Tyr Leu Leu Ser Met  Gly Ser Asn Glu Asn  Ile His Ser 
    1055                 1060                 1065             


Ile His  Phe Ser Gly His Val  Phe Thr Val Arg Lys  Lys Glu Glu 
    1070                 1075                 1080             


Tyr Lys  Met Ala Leu Tyr Asn  Leu Tyr Pro Gly Val  Phe Glu Thr 
    1085                 1090                 1095             


Val Glu  Met Leu Pro Ser Lys  Ala Gly Ile Trp Arg  Val Glu Cys 
    1100                 1105                 1110             


Leu Ile  Gly Glu His Leu His  Ala Gly Met Ser Thr  Leu Phe Leu 
    1115                 1120                 1125             


Val Tyr  Ser Asn Lys Cys Gln  Thr Pro Leu Gly Met  Ala Ser Gly 
    1130                 1135                 1140             


His Ile  Arg Asp Phe Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln 
    1145                 1150                 1155             


Trp Ala  Pro Lys Leu Ala Arg  Leu His Tyr Ser Gly  Ser Ile Asn 
    1160                 1165                 1170             


Ala Trp  Ser Thr Lys Glu Pro  Phe Ser Trp Ile Lys  Val Asp Leu 
    1175                 1180                 1185             


Leu Ala  Pro Met Ile Ile His  Gly Ile Lys Thr Gln  Gly Ala Arg 
    1190                 1195                 1200             


Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln Phe Ile  Ile Met Tyr 
    1205                 1210                 1215             


Ser Leu  Asp Gly Lys Lys Trp  Gln Thr Tyr Arg Gly  Asn Ser Thr 
    1220                 1225                 1230             


Gly Thr  Leu Met Val Phe Phe  Gly Asn Val Asp Ser  Ser Gly Ile 
    1235                 1240                 1245             


Lys His  Asn Ile Phe Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg 
    1250                 1255                 1260             


Leu His  Pro Thr His Tyr Ser  Ile Arg Ser Thr Leu  Arg Met Glu 
    1265                 1270                 1275             


Leu Met  Gly Cys Asp Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met 
    1280                 1285                 1290             


Glu Ser  Lys Ala Ile Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr 
    1295                 1300                 1305             


Phe Thr  Asn Met Phe Ala Thr  Trp Ser Pro Ser Lys  Ala Arg Leu 
    1310                 1315                 1320             


His Leu  Gln Gly Arg Ser Asn  Ala Trp Arg Pro Gln  Val Asn Asn 
    1325                 1330                 1335             


Pro Lys  Glu Trp Leu Gln Val  Asp Phe Gln Lys Thr  Met Lys Val 
    1340                 1345                 1350             


Thr Gly  Val Thr Thr Gln Gly  Val Lys Ser Leu Leu  Thr Ser Met 
    1355                 1360                 1365             


Tyr Val  Lys Glu Phe Leu Ile  Ser Ser Ser Gln Asp  Gly His Gln 
    1370                 1375                 1380             


Trp Thr  Leu Phe Phe Gln Asn  Gly Lys Val Lys Val  Phe Gln Gly 
    1385                 1390                 1395             


Asn Gln  Asp Ser Phe Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro 
    1400                 1405                 1410             


Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro Gln Ser  Trp Val His 
    1415                 1420                 1425             


Gln Ile  Ala Leu Arg Met Glu  Val Leu Gly Cys Glu  Ala Gln Asp 
    1430                 1435                 1440             


Leu Tyr  Gly Ser Phe Ser Gln  Asn Ser Arg His Pro  Ser Thr Arg 
    1445                 1450                 1455             


Gln Lys  Gln Phe Asn Ala Thr  Thr Ile Pro Glu Asn  Asp Ile Glu 
    1460                 1465                 1470             


Lys Thr  Asp Pro Trp Phe Ala  His Arg Thr Pro Met  Pro Lys Ile 
    1475                 1480                 1485             


Gln Asn  Val Ser Ser Ser Asp  Leu Leu Met Leu Leu  Arg Gln Ser 
    1490                 1495                 1500             


Pro Thr  Pro His Gly Leu Ser  Leu Ser Asp Leu Gln  Glu Ala Lys 
    1505                 1510                 1515             


Tyr Glu  Thr Phe Ser Asp Asp  Pro Ser Pro Gly Ala  Ile Asp Ser 
    1520                 1525                 1530             


Asn Asn  Ser Leu Ser Glu Met  Thr His Phe Arg Pro  Gln Leu His 
    1535                 1540                 1545             


His Ser  Gly Asp Met Val Phe  Thr Pro Glu Ser Gly  Leu Gln Leu 
    1550                 1555                 1560             


Arg Leu  Asn Glu Lys Leu Gly  Thr Thr Ala Ala Thr  Glu Leu Lys 
    1565                 1570                 1575             


Lys Leu  Asp Phe Lys Val Ser  Ser Thr Ser Asn Asn  Leu Ile Ser 
    1580                 1585                 1590             


Thr Ile  Pro Ser Asp Asn Leu  Ala Ala Gly Thr Asp  Asn Thr Ser 
    1595                 1600                 1605             


Ser Leu  Gly Pro Pro Ser Met  Pro Val His Tyr Asp  Ser Gln Leu 
    1610                 1615                 1620             


Asp Thr  Thr Leu Phe Gly Lys  Lys Ser Ser Pro Leu  Thr Glu Ser 
    1625                 1630                 1635             


Gly Gly  Pro Leu Ser Leu Ser  Glu Glu Asn Asn Asp  Ser Lys Leu 
    1640                 1645                 1650             


Leu Glu  Ser Gly Leu Met Asn  Ser Gln Glu Ser Ser  Trp Gly Lys 
    1655                 1660                 1665             


Asn Val  Ser Ser 
    1670         


<210>  36
<211>  1694
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  36

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu 
        755                 760                 765             


Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu 
    770                 775                 780                 


Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 
785                 790                 795                 800 


Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
                805                 810                 815     


Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
            820                 825                 830         


Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
        835                 840                 845             


Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
    850                 855                 860                 


Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
865                 870                 875                 880 


Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
                885                 890                 895     


Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
            900                 905                 910         


Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
        915                 920                 925             


Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
    930                 935                 940                 


Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
945                 950                 955                 960 


His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
                965                 970                 975     


Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
            980                 985                 990         


Phe Thr Ile Phe Asp Glu Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met 
        995                 1000                 1005             


Glu Arg  Asn Cys Arg Ala Pro  Cys Asn Ile Gln Met  Glu Asp Pro 
    1010                 1015                 1020             


Thr Phe  Lys Glu Asn Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Ile 
    1025                 1030                 1035             


Met Asp  Thr Leu Pro Gly Leu  Val Met Ala Gln Asp  Gln Arg Ile 
    1040                 1045                 1050             


Arg Trp  Tyr Leu Leu Ser Met  Gly Ser Asn Glu Asn  Ile His Ser 
    1055                 1060                 1065             


Ile His  Phe Ser Gly His Val  Phe Thr Val Arg Lys  Lys Glu Glu 
    1070                 1075                 1080             


Tyr Lys  Met Ala Leu Tyr Asn  Leu Tyr Pro Gly Val  Phe Glu Thr 
    1085                 1090                 1095             


Val Glu  Met Leu Pro Ser Lys  Ala Gly Ile Trp Arg  Val Glu Cys 
    1100                 1105                 1110             


Leu Ile  Gly Glu His Leu His  Ala Gly Met Ser Thr  Leu Phe Leu 
    1115                 1120                 1125             


Val Tyr  Ser Asn Lys Cys Gln  Thr Pro Leu Gly Met  Ala Ser Gly 
    1130                 1135                 1140             


His Ile  Arg Asp Phe Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln 
    1145                 1150                 1155             


Trp Ala  Pro Lys Leu Ala Arg  Leu His Tyr Ser Gly  Ser Ile Asn 
    1160                 1165                 1170             


Ala Trp  Ser Thr Lys Glu Pro  Phe Ser Trp Ile Lys  Val Asp Leu 
    1175                 1180                 1185             


Leu Ala  Pro Met Ile Ile His  Gly Ile Lys Thr Gln  Gly Ala Arg 
    1190                 1195                 1200             


Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln Phe Ile  Ile Met Tyr 
    1205                 1210                 1215             


Ser Leu  Asp Gly Lys Lys Trp  Gln Thr Tyr Arg Gly  Asn Ser Thr 
    1220                 1225                 1230             


Gly Thr  Leu Met Val Phe Phe  Gly Asn Val Asp Ser  Ser Gly Ile 
    1235                 1240                 1245             


Lys His  Asn Ile Phe Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg 
    1250                 1255                 1260             


Leu His  Pro Thr His Tyr Ser  Ile Arg Ser Thr Leu  Arg Met Glu 
    1265                 1270                 1275             


Leu Met  Gly Cys Asp Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met 
    1280                 1285                 1290             


Glu Ser  Lys Ala Ile Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr 
    1295                 1300                 1305             


Phe Thr  Asn Met Phe Ala Thr  Trp Ser Pro Ser Lys  Ala Arg Leu 
    1310                 1315                 1320             


His Leu  Gln Gly Arg Ser Asn  Ala Trp Arg Pro Gln  Val Asn Asn 
    1325                 1330                 1335             


Pro Lys  Glu Trp Leu Gln Val  Asp Phe Gln Lys Thr  Met Lys Val 
    1340                 1345                 1350             


Thr Gly  Val Thr Thr Gln Gly  Val Lys Ser Leu Leu  Thr Ser Met 
    1355                 1360                 1365             


Tyr Val  Lys Glu Phe Leu Ile  Ser Ser Ser Gln Asp  Gly His Gln 
    1370                 1375                 1380             


Trp Thr  Leu Phe Phe Gln Asn  Gly Lys Val Lys Val  Phe Gln Gly 
    1385                 1390                 1395             


Asn Gln  Asp Ser Phe Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro 
    1400                 1405                 1410             


Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro Gln Ser  Trp Val His 
    1415                 1420                 1425             


Gln Ile  Ala Leu Arg Met Glu  Val Leu Gly Cys Glu  Ala Gln Asp 
    1430                 1435                 1440             


Leu Tyr  Gly Gly Gly Ser Gly  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1445                 1450                 1455             


Gly Gly  Ser Gly Gly Gly Ser  Gly Gly Gly Ser Phe  Ser Gln Asn 
    1460                 1465                 1470             


Ser Arg  His Pro Ser Thr Arg  Gln Lys Gln Phe Asn  Ala Thr Thr 
    1475                 1480                 1485             


Ile Pro  Glu Asn Asp Ile Glu  Lys Thr Asp Pro Trp  Phe Ala His 
    1490                 1495                 1500             


Arg Thr  Pro Met Pro Lys Ile  Gln Asn Val Ser Ser  Ser Asp Leu 
    1505                 1510                 1515             


Leu Met  Leu Leu Arg Gln Ser  Pro Thr Pro His Gly  Leu Ser Leu 
    1520                 1525                 1530             


Ser Asp  Leu Gln Glu Ala Lys  Tyr Glu Thr Phe Ser  Asp Asp Pro 
    1535                 1540                 1545             


Ser Pro  Gly Ala Ile Asp Ser  Asn Asn Ser Leu Ser  Glu Met Thr 
    1550                 1555                 1560             


His Phe  Arg Pro Gln Leu His  His Ser Gly Asp Met  Val Phe Thr 
    1565                 1570                 1575             


Pro Glu  Ser Gly Leu Gln Leu  Arg Leu Asn Glu Lys  Leu Gly Thr 
    1580                 1585                 1590             


Thr Ala  Ala Thr Glu Leu Lys  Lys Leu Asp Phe Lys  Val Ser Ser 
    1595                 1600                 1605             


Thr Ser  Asn Asn Leu Ile Ser  Thr Ile Pro Ser Asp  Asn Leu Ala 
    1610                 1615                 1620             


Ala Gly  Thr Asp Asn Thr Ser  Ser Leu Gly Pro Pro  Ser Met Pro 
    1625                 1630                 1635             


Val His  Tyr Asp Ser Gln Leu  Asp Thr Thr Leu Phe  Gly Lys Lys 
    1640                 1645                 1650             


Ser Ser  Pro Leu Thr Glu Ser  Gly Gly Pro Leu Ser  Leu Ser Glu 
    1655                 1660                 1665             


Glu Asn  Asn Asp Ser Lys Leu  Leu Glu Ser Gly Leu  Met Asn Ser 
    1670                 1675                 1680             


Gln Glu  Ser Ser Trp Gly Lys  Asn Val Ser Ser 
    1685                 1690                 


<210>  37
<211>  1671
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  37

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gln Asn 
            740                 745                 750         


Pro Pro Val Leu Lys Arg His Gln Arg Ser Phe Ser Gln Asn Ser Arg 
        755                 760                 765             


His Pro Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu 
    770                 775                 780                 


Asn Asp Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met 
785                 790                 795                 800 


Pro Lys Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg 
                805                 810                 815     


Gln Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala 
            820                 825                 830         


Lys Tyr Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser 
        835                 840                 845             


Asn Asn Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His 
    850                 855                 860                 


Ser Gly Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu 
865                 870                 875                 880 


Asn Glu Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp 
                885                 890                 895     


Phe Lys Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser 
            900                 905                 910         


Asp Asn Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro 
        915                 920                 925             


Ser Met Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly 
    930                 935                 940                 


Lys Lys Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser 
945                 950                 955                 960 


Glu Glu Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser 
                965                 970                 975     


Gln Glu Ser Ser Trp Gly Lys Asn Val Ser Ser Glu Ile Thr Arg Thr 
            980                 985                 990         


Thr Leu Gln Ser Asp Gln Glu Glu  Ile Asp Tyr Asp Asp  Thr Ile Ser 
        995                 1000                 1005             


Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile Tyr Asp  Glu Asp Glu 
    1010                 1015                 1020             


Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys Thr Arg  His Tyr Phe 
    1025                 1030                 1035             


Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr Gly Met  Ser Ser Ser 
    1040                 1045                 1050             


Pro His  Val Leu Arg Asn Arg  Ala Gln Ser Gly Ser  Val Pro Gln 
    1055                 1060                 1065             


Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr Asp Gly  Ser Phe Thr 
    1070                 1075                 1080             


Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu His Leu  Gly Leu Leu 
    1085                 1090                 1095             


Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp Asn Ile  Met Val Thr 
    1100                 1105                 1110             


Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser Phe Tyr  Ser Ser Leu 
    1115                 1120                 1125             


Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly Ala Glu  Pro Arg Lys 
    1130                 1135                 1140             


Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr Tyr Phe  Trp Lys Val 
    1145                 1150                 1155             


Gln His  His Met Ala Pro Thr  Lys Asp Glu Phe Asp  Cys Lys Ala 
    1160                 1165                 1170             


Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu Lys Asp  Val His Ser 
    1175                 1180                 1185             


Gly Leu  Ile Gly Pro Leu Leu  Val Cys His Thr Asn  Thr Leu Asn 
    1190                 1195                 1200             


Pro Ala  His Gly Arg Gln Val  Thr Val Gln Glu Phe  Ala Leu Phe 
    1205                 1210                 1215             


Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp Tyr Phe  Thr Glu Asn 
    1220                 1225                 1230             


Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn Ile Gln  Met Glu Asp 
    1235                 1240                 1245             


Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His Ala Ile  Asn Gly Tyr 
    1250                 1255                 1260             


Ile Met  Asp Thr Leu Pro Gly  Leu Val Met Ala Gln  Asp Gln Arg 
    1265                 1270                 1275             


Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser Asn Glu  Asn Ile His 
    1280                 1285                 1290             


Ser Ile  His Phe Ser Gly His  Val Phe Thr Val Arg  Lys Lys Glu 
    1295                 1300                 1305             


Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr Pro Gly  Val Phe Glu 
    1310                 1315                 1320             


Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly Ile Trp  Arg Val Glu 
    1325                 1330                 1335             


Cys Leu  Ile Gly Glu His Leu  His Ala Gly Met Ser  Thr Leu Phe 
    1340                 1345                 1350             


Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro Leu Gly  Met Ala Ser 
    1355                 1360                 1365             


Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala Ser Gly  Gln Tyr Gly 
    1370                 1375                 1380             


Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His Tyr Ser  Gly Ser Ile 
    1385                 1390                 1395             


Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser Trp Ile  Lys Val Asp 
    1400                 1405                 1410             


Leu Leu  Ala Pro Met Ile Ile  His Gly Ile Lys Thr  Gln Gly Ala 
    1415                 1420                 1425             


Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser Gln Phe  Ile Ile Met 
    1430                 1435                 1440             


Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr Tyr Arg  Gly Asn Ser 
    1445                 1450                 1455             


Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn Val Asp  Ser Ser Gly 
    1460                 1465                 1470             


Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile Ile Ala  Arg Tyr Ile 
    1475                 1480                 1485             


Arg Leu  His Pro Thr His Tyr  Ser Ile Arg Ser Thr  Leu Arg Met 
    1490                 1495                 1500             


Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys Ser Met  Pro Leu Gly 
    1505                 1510                 1515             


Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln Ile Thr  Ala Ser Ser 
    1520                 1525                 1530             


Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser Pro Ser  Lys Ala Arg 
    1535                 1540                 1545             


Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp Arg Pro  Gln Val Asn 
    1550                 1555                 1560             


Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe Gln Lys  Thr Met Lys 
    1565                 1570                 1575             


Val Thr  Gly Val Thr Thr Gln  Gly Val Lys Ser Leu  Leu Thr Ser 
    1580                 1585                 1590             


Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser Ser Gln  Asp Gly His 
    1595                 1600                 1605             


Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys Val Lys  Val Phe Gln 
    1610                 1615                 1620             


Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val Asn Ser  Leu Asp Pro 
    1625                 1630                 1635             


Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His Pro Gln  Ser Trp Val 
    1640                 1645                 1650             


His Gln  Ile Ala Leu Arg Met  Glu Val Leu Gly Cys  Glu Ala Gln 
    1655                 1660                 1665             


Asp Leu  Tyr 
    1670     


<210>  38
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic

<400>  38

Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
1               5                   10          


