                         SEQUENCE LISTING

<110>  WuXi Biologics (Shanghai) Co. Ltd.
 
<120>  Novel Anti-PD-L1 Antibodies

<130>  053674-8007WO01

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  1

Ser Gly Tyr Ile Trp His 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  2

Tyr Ile His Tyr Ser Gly Thr Thr Asp Phe Asn Pro Ser Leu Glu Ser 
1               5                   10                  15      


<210>  3
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  3

Glu Gly Arg Ser Tyr Gly Gly Phe Ala Tyr 
1               5                   10  


<210>  4
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  4

Lys Ala Ser Gln Ser Val Ser Asn Gly Val Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Tyr Ala Ser Asn Arg Phe Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Gln Asp Tyr Ser Ser Pro Phe Thr 
1               5                   


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ile Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Tyr Ser Gly Thr Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Glu Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Arg Ser Tyr Gly Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  8
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  8
caggtgcagc tgcaggagag cggaccaggc ctggtcaagc cctctgaaac actgagtctg       60

acttgcaccg tgtctggata cagtatcacc tcaggctata tctggcactg gattaggcag      120

ccccctggga aaggactgga gtggatcggg tacattcatt atagtggcac cacagacttc      180

aaccccagcc tggaatcccg ggtgactatt tcagtcgata ccagcaagaa tcagttttct      240

ctgaaactga gctccgtgac cgccgctgat acagcagtct actattgtgc ccgggagggc      300

agatcctacg gcggattcgc ttattggggc caggggacac tggtgactgt ctctgcc         357


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  9

Ser Phe Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Phe Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Glu Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  10
tcattcgtga tgactcagag tcctagctcc ctgtccgctt ctgtggggga cagggtcacc       60

atcacatgca aagcaagtca gtcagtgagc aacggagtcg cctggtacca gcagaagccc      120

ggcaaagtgc ctaagctgct gatctactac gcttccaatc ggttcaccgg cgtcccctct      180

agattttccg gctctgggag tggaacagac ttcaccctga ccatctctag tctgcagcca      240

gaggacgtgg ccacatacta ttgtcagcag gattactcaa gccccttcac atttggcagc      300

gggactgagc tggaaattaa g                                                321


<210>  11
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ile Trp His Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Tyr Ser Gly Thr Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Glu Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Arg Ser Tyr Gly Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  12
caggtgcagc tgcaggagtc tggacctgga ctggtcaagc cttccgaaac tctgtctctg       60

acttgcaccg tgacaggata ctctatcacc agtggctata tctggcactg gattaggcag      120

ccagccggga aaggactgga gtggatcggg tacattcatt attctggcac cacagacttc      180

aacccctcac tggaaagccg ggtgaccatt agtgtcgata catcaaagaa tcagttttcc      240

ctgaaactga gctccgtgac agccgctgat actgcagtct actattgtgc ccgggagggc      300

agaagctacg gcggattcgc ttattgggga caggggactc tggtgaccgt ctccagt         357


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  13

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Phe Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  14
gacatccagc tgactcagtc acctagcttt ctgtccgcat ctgtggggga cagggtcacc       60

atcacatgca aagcaagtca gtcagtgagc aacggagtcg cctggtacca gcagaagccc      120

ggcaaagctc ctaagctgct gatctactac gcttctaatc ggttcaccgg cgtccccagc      180

agattttccg gctctgggag tggaacagag ttcactctga ccatcagctc cctgcagcca      240

gaagactttg ccacatacta ttgtcagcag gattactcta gtcccttcac atttggccag      300

gggactaaac tggaaattaa g                                                321


<210>  15
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  15
caggtgcagc tgcaggagtc tggacctgga ctggtcaagc cttccgaaac tctgtctctg       60

acttgcaccg tgacaggata ctctatcacc agtggctata tctggcactg gattaggcag      120

ccagccggga aaggactgga gtggatcggg tacattcatt attctggcac cacagacttc      180

aacccctcac tggaaagccg ggtgaccatt agtgtcgata catcaaagaa tcagttttcc      240

ctgaaactga gctccgtgac agccgctgat actgcagtct actattgtgc ccgggagggc      300

agaagctacg gcggattcgc ttattgggga caggggactc tggtgaccgt ctccagt         357


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Phe Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  17
gacatccaga tgactcagag tcctagctcc ctgtccgctt ctgtggggga cagggtcacc       60

atcacatgca aagcaagtca gtcagtgagc aacggagtcg cctggtacca gcagaagccc      120

ggcaaagtgc ctaagctgct gatctactac gcttccaatc ggttcaccgg cgtcccctct      180

agattttccg gctctgggag tggaacagac ttcaccctga ccatctctag tctgcagcca      240

gaggacgtgg ccacatacta ttgtcagcag gattactcaa gccccttcac atttggccag      300

gggactaaac tggaaattaa g                                                321


<210>  18
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ile Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Tyr Ser Gly Thr Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Glu Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Arg Ser Tyr Gly Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  19
caggtgcagc tgcaggagag cggaccaggc ctggtcaagc cctctgaaac actgagtctg       60

acttgcaccg tgtctggata cagtatcacc tcaggctata tctggcactg gattaggcag      120

ccccctggga aaggactgga gtggatcggg tacattcatt atagtggcac cacagacttc      180

aaccccagcc tggaatcccg ggtgactatt tcagtcgata ccagcaagaa tcagttttct      240

ctgaaactga gctccgtgac cgccgctgat acagcagtct actattgtgc ccgggagggc      300

agatcctacg gcggattcgc ttattggggc caggggacac tggtgactgt ctctagt         357


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  20

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Phe Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  21

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Ala Gly Cys Gly Gly Ala Cys Cys Ala Gly Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Thr Cys Ala Ala Gly Cys Cys Cys Thr Cys Thr Gly Ala Ala 
        35                  40                  45              


Ala Cys Ala Cys Thr Gly Ala Gly Thr Cys Thr Gly Ala Cys Thr Thr 
    50                  55                  60                  


Gly Cys Ala Cys Cys Gly Thr Gly Thr Cys Thr Gly Gly Ala Thr Ala 
65                  70                  75                  80  


Cys Ala Gly Thr Ala Thr Cys Ala Cys Cys Thr Cys Ala Gly Gly Cys 
                85                  90                  95      


Thr Ala Thr Ala Thr Cys Thr Gly Gly Cys Ala Cys Thr Gly Gly Ala 
            100                 105                 110         


Thr Thr Ala Gly Gly Cys Ala Gly Cys Cys Cys Cys Cys Thr Gly Gly 
        115                 120                 125             


Gly Ala Ala Ala Gly Gly Ala Cys Thr Gly Gly Ala Gly Thr Gly Gly 
    130                 135                 140                 


Ala Thr Cys Gly Gly Gly Thr Ala Cys Ala Thr Thr Cys Ala Thr Thr 
145                 150                 155                 160 


Ala Thr Ala Gly Thr Gly Gly Cys Ala Cys Cys Ala Cys Ala Gly Ala 
                165                 170                 175     


Cys Thr Thr Cys Ala Ala Cys Cys Cys Cys Ala Gly Cys Cys Thr Gly 
            180                 185                 190         


Gly Ala Ala Thr Cys Cys Cys Gly Gly Gly Thr Gly Ala Cys Thr Ala 
        195                 200                 205             


Thr Thr Thr Cys Ala Gly Thr Cys Gly Ala Thr Ala Cys Cys Ala Gly 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Thr Cys Ala Gly Thr Thr Thr Thr Cys Thr 
225                 230                 235                 240 


Cys Thr Gly Ala Ala Ala Cys Thr Gly Ala Gly Cys Thr Cys Cys Gly 
                245                 250                 255     


Thr Gly Ala Cys Cys Gly Cys Cys Gly Cys Thr Gly Ala Thr Ala Cys 
            260                 265                 270         


Ala Gly Cys Ala Gly Thr Cys Thr Ala Cys Thr Ala Thr Thr Gly Thr 
        275                 280                 285             


Gly Cys Cys Cys Gly Gly Gly Ala Gly Gly Gly Cys Ala Gly Ala Thr 
    290                 295                 300                 


Cys Cys Thr Ala Cys Gly Gly Cys Gly Gly Ala Thr Thr Cys Gly Cys 
305                 310                 315                 320 


Thr Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Gly 
                325                 330                 335     


Ala Cys Ala Cys Thr Gly Gly Thr Gly Ala Cys Thr Gly Thr Cys Thr 
            340                 345                 350         


Cys Thr Ala Gly Thr 
        355         


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Phe Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized

<400>  23
gacatccaga tgactcagag tcctagctcc ctgtccgctt ctgtggggga cagggtcacc       60

atcacatgca aagcaagtca gtcagtgagc aacggagtcg cctggtacca gcagaagccc      120

ggcaaagtgc ctaagctgct gatctactac gcttccaatc ggttcaccgg cgtcccctct      180

agattttccg gctctgggag tggaacagac ttcaccctga ccatctctag tctgcagcca      240

gaggacgtgg ccacatacta ttgtcagcag gattactcaa gccccttcac atttggccag      300

gggactaaac tggaaattaa g                                                321



