SEQUENCE LISTING

<110>  The Walter and Eliza Hall Institute of Medical Research
 
<120>  STRUCTURE OF PLASMEPSIN V IN COMPLEX WITH AN INHIBITOR AND USES 
       THEREOF

<130>  A/16/293

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  590
<212>  PRT
<213>  Plasmodium falciparum (isolate 3D7)

<400>  1

Met Asn Asn Tyr Phe Leu Arg Lys Glu Asn Phe Phe Ile Leu Phe Cys 
1               5                   10                  15      

Phe Val Phe Val Ser Ile Phe Phe Val Ser Asn Val Thr Ile Ile Lys 
            20                  25                  30          

Cys Asn Asn Val Glu Asn Lys Ile Asp Asn Val Gly Lys Lys Ile Glu 
        35                  40                  45              

Asn Val Gly Lys Lys Ile Gly Asp Met Glu Asn Lys Asn Asp Asn Val 
    50                  55                  60                  

Glu Asn Lys Asn Asp Asn Val Gly Asn Lys Asn Asp Asn Val Lys Asn 
65                  70                  75                  80  

Ala Ser Ser Asp Leu Tyr Lys Tyr Lys Leu Tyr Gly Asp Ile Asp Glu 
                85                  90                  95      

Tyr Ala Tyr Tyr Phe Leu Asp Ile Asp Ile Gly Lys Pro Ser Gln Arg 
            100                 105                 110         

Ile Ser Leu Ile Leu Asp Thr Gly Ser Ser Ser Leu Ser Phe Pro Cys 
        115                 120                 125             

Asn Gly Cys Lys Asp Cys Gly Ile His Met Glu Lys Pro Tyr Asn Leu 
    130                 135                 140                 

Asn Tyr Ser Lys Thr Ser Ser Ile Leu Tyr Cys Asn Lys Ser Asn Cys 
145                 150                 155                 160 

Pro Tyr Gly Leu Lys Cys Val Gly Asn Lys Cys Glu Tyr Leu Gln Ser 
                165                 170                 175     

Tyr Cys Glu Gly Ser Gln Ile Tyr Gly Phe Tyr Phe Ser Asp Ile Val 
            180                 185                 190         

Thr Leu Pro Ser Tyr Asn Asn Lys Asn Lys Ile Ser Phe Glu Lys Leu 
        195                 200                 205             

Met Gly Cys His Met His Glu Glu Ser Leu Phe Leu His Gln Gln Ala 
    210                 215                 220                 

Thr Gly Val Leu Gly Phe Ser Leu Thr Lys Pro Asn Gly Val Pro Thr 
225                 230                 235                 240 

Phe Val Asp Leu Leu Phe Lys His Thr Pro Ser Leu Lys Pro Ile Tyr 
                245                 250                 255     

Ser Ile Cys Val Ser Glu His Gly Gly Glu Leu Ile Ile Gly Gly Tyr 
            260                 265                 270         

Glu Pro Asp Tyr Phe Leu Ser Asn Gln Lys Glu Lys Gln Lys Met Asp 
        275                 280                 285             

Lys Ser Asp Asn Asn Ser Ser Asn Lys Gly Asn Val Ser Ile Lys Leu 
    290                 295                 300                 

Lys Asn Asn Asp Lys Asn Asp Asp Glu Glu Asn Asn Ser Lys Asp Val 
305                 310                 315                 320 

Ile Val Ser Asn Asn Val Glu Asp Ile Val Trp Gln Ala Ile Thr Arg 
                325                 330                 335     

Lys Tyr Tyr Tyr Tyr Ile Lys Ile Tyr Gly Leu Asp Leu Tyr Gly Thr 
            340                 345                 350         

Asn Ile Met Asp Lys Lys Glu Leu Asp Met Leu Val Asp Ser Gly Ser 
        355                 360                 365             

Thr Phe Thr His Ile Pro Glu Asn Ile Tyr Asn Gln Ile Asn Tyr Tyr 
    370                 375                 380                 

Leu Asp Ile Leu Cys Ile His Asp Met Thr Asn Ile Tyr Glu Ile Asn 
385                 390                 395                 400 

Lys Arg Leu Lys Leu Thr Asn Glu Ser Leu Asn Lys Pro Leu Val Tyr 
                405                 410                 415     

Phe Glu Asp Phe Lys Thr Ala Leu Lys Asn Ile Ile Gln Asn Glu Asn 
            420                 425                 430         

Leu Cys Ile Lys Ile Val Asp Gly Val Gln Cys Trp Lys Ser Leu Glu 
        435                 440                 445             

Asn Leu Pro Asn Leu Tyr Ile Thr Leu Ser Asn Asn Tyr Lys Met Ile 
    450                 455                 460                 

Trp Lys Pro Ser Ser Tyr Leu Tyr Lys Lys Glu Ser Phe Trp Cys Lys 
465                 470                 475                 480 

Gly Leu Glu Lys Gln Val Asn Asn Lys Pro Ile Leu Gly Leu Thr Phe 
                485                 490                 495     

Phe Lys Asn Lys Gln Val Ile Phe Asp Leu Gln Gln Asn Gln Ile Ala 
            500                 505                 510         

Phe Ile Glu Ser Lys Cys Pro Ser Asn Leu Thr Ser Ser Arg Pro Arg 
        515                 520                 525             

Thr Phe Asn Glu Tyr Arg Glu Lys Glu Asn Ile Phe Leu Lys Val Ser 
    530                 535                 540                 

Tyr Ile Asn Leu Tyr Cys Leu Trp Leu Leu Leu Ala Leu Thr Ile Leu 
545                 550                 555                 560 

Leu Ser Leu Ile Leu Tyr Val Arg Lys Met Phe Tyr Met Asp Tyr Phe 
                565                 570                 575     

Pro Leu Ser Asp Gln Asn Lys Ser Pro Ile Gln Glu Ser Thr 
            580                 585                 590 


<210>  2
<211>  536
<212>  PRT
<213>  Plasmodium vivax (strain Salvador I)

<400>  2

Met Val Gly Ala Ser Leu Gly Pro Pro Gly Arg Gly Ser Leu Ser Arg 
1               5                   10                  15      

Leu Ile Arg Leu Val Ile Cys Val Leu Thr Leu Cys Ala Leu Ser Val 
            20                  25                  30          

Gln Gly Arg Ser Glu Ser Thr Glu Gly His Ser Lys Asp Leu Leu Tyr 
        35                  40                  45              

Lys Tyr Lys Leu Tyr Gly Asp Ile Asp Glu Tyr Ala Tyr Tyr Phe Leu 
    50                  55                  60                  

Asp Ile Asp Ile Gly Thr Pro Glu Gln Arg Ile Ser Leu Ile Leu Asp 
65                  70                  75                  80  

Thr Gly Ser Ser Ser Leu Ser Phe Pro Cys Ala Gly Cys Lys Asn Cys 
                85                  90                  95      

Gly Val His Met Glu Asn Pro Phe Asn Leu Asn Asn Ser Lys Thr Ser 
            100                 105                 110         

Ser Ile Leu Tyr Cys Glu Asn Glu Glu Cys Pro Phe Lys Leu Asn Cys 
        115                 120                 125             

Val Lys Gly Lys Cys Glu Tyr Met Gln Ser Tyr Cys Glu Gly Ser Gln 
    130                 135                 140                 

Ile Ser Gly Phe Tyr Phe Ser Asp Val Val Ser Val Val Ser Tyr Asn 
145                 150                 155                 160 

Asn Glu Arg Val Thr Phe Arg Lys Leu Met Gly Cys His Met His Glu 
                165                 170                 175     

Glu Ser Leu Phe Leu Tyr Gln Gln Ala Thr Gly Val Leu Gly Met Ser 
            180                 185                 190         

Leu Ser Lys Pro Gln Gly Ile Pro Thr Phe Val Asn Leu Leu Phe Asp 
        195                 200                 205             

Asn Ala Pro Gln Leu Lys Gln Val Phe Thr Ile Cys Ile Ser Glu Asn 
    210                 215                 220                 

Gly Gly Glu Leu Ile Ala Gly Gly Tyr Asp Pro Ala Tyr Ile Val Arg 
225                 230                 235                 240 

Arg Gly Gly Ser Lys Ser Val Ser Gly Gln Gly Ser Gly Pro Val Ser 
                245                 250                 255     

Glu Ser Leu Ser Glu Ser Gly Glu Asp Pro Gln Val Ala Leu Arg Glu 
            260                 265                 270         

Ala Glu Lys Val Val Trp Glu Asn Val Thr Arg Lys Tyr Tyr Tyr Tyr 
        275                 280                 285             

Ile Lys Val Arg Gly Leu Asp Met Phe Gly Thr Asn Met Met Ser Ser 
    290                 295                 300                 

Ser Lys Gly Leu Glu Met Leu Val Asp Ser Gly Ser Thr Phe Thr His 
305                 310                 315                 320 

Ile Pro Glu Asp Leu Tyr Asn Lys Leu Asn Tyr Phe Phe Asp Ile Leu 
                325                 330                 335     

Cys Ile Gln Asp Met Asn Asn Ala Tyr Asp Val Asn Lys Arg Leu Lys 
            340                 345                 350         

Met Thr Asn Glu Ser Phe Asn Asn Pro Leu Val Gln Phe Asp Asp Phe 
        355                 360                 365             

Arg Lys Ser Leu Lys Ser Ile Ile Ala Lys Glu Asn Met Cys Val Lys 
    370                 375                 380                 

Ile Val Asp Gly Val Gln Cys Trp Lys Tyr Leu Glu Gly Leu Pro Asp 
385                 390                 395                 400 

Leu Phe Val Thr Leu Ser Asn Asn Tyr Lys Met Lys Trp Gln Pro His 
                405                 410                 415     

Ser Tyr Leu Tyr Lys Lys Glu Ser Phe Trp Cys Lys Gly Ile Glu Lys 
            420                 425                 430         

Gln Val Asn Asn Lys Pro Ile Leu Gly Leu Thr Phe Phe Lys Asn Arg 
        435                 440                 445             

Gln Val Ile Phe Asp Ile Gln Lys Asn Arg Ile Gly Phe Val Asp Ala 
    450                 455                 460                 

Asn Cys Pro Ser His Pro Thr His Thr Arg Pro Arg Thr Tyr Asn Glu 
465                 470                 475                 480 

Tyr Lys Arg Lys Asp Asn Ile Phe Leu Lys Ile Pro Phe Phe Tyr Leu 
                485                 490                 495     

Tyr Ser Leu Phe Val Val Phe Ala Leu Ser Val Leu Leu Ser Leu Val 
            500                 505                 510         

Phe Tyr Val Arg Arg Leu Tyr His Met Glu Tyr Ser Pro Leu Pro Ser 
        515                 520                 525             

Glu Gly Lys Ala Pro Ala Asp Ala 
    530                 535     


<210>  3
<211>  1686
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence for recombinant P. vivax plasmepsin V 
       (includes fusion tag comprising a FLAG tag, a SUMO domain and a 
       TEV protease cleavage site)

<400>  3
gactacaaag acgatgacga caaggggtcc ctgcaggact cagaagtcaa tcaagaagct    60

aagccagagg tcaagccaga agtcaagcct gagactcaca tcaatttaaa ggtgtccgat   120

ggatcttcag agatcttctt caagatcaaa aagaccactc ctttaagaag gctgatggaa   180

gcgttcgcta aaagacaggg taaggaaatg gactccttaa cgttcttgta cgacggtatt   240

gaaattcaag ctgatcagac ccctgaagat ttggacatgg aggataacga tattattgag   300

gctcacagag aacagattgg aggtgagaac ttgtacttcc aaggtacccg ttccgagtct   360

accgagggcc actccaagga cctgctgtac aagtacaagc tgtacggcga catcgacgag   420

tacgcttact acttcctgga catcgacatc ggcacccccg agcagcgcat ctccctgatc   480

ctggataccg gttcctccag cctgtccttc ccttgcgctg gttgcaagaa ctgcggtgtc   540

cacatggaaa accccttcaa cctgaacaac tccaagacct cctccatcct gtactgcgag   600

aacgaggaat gccctttcaa gctgaactgc gtgaagggca agtgcgagta catgcagtcc   660

tactgcgagg gttcccagat ctccggtttc tacttctccg acgtggtgtc cgtcgtgtcc   720

tacaacaacg agcgtgtgac cttccgcaag ctgatgggtt gccacatgca cgaagagtcc   780

ctgttcctct accagcaagc taccggcgtg ctgggcatgt ccctgtccaa gcctcagggt   840

atccccacct tcgtgaacct gctgttcgac aacgctcccc agctgaagca agtgttcacc   900

atctgcatct ccgagaacgg tggcgagctg atcgctggtg gttacgaccc cgcttacatc   960

gtgcgtcgtg gtggttccaa gtccgtgtcc ggccagggtt ctggtcctgt gtccgagtct  1020

ctgtctgagt ccggcgagga cccccaagtg gctctgaggg aagctgagaa ggtcgtgtgg  1080

gagaacgtga cccgcaagta ctactactac atcaaagtgc gcggcctgga catgttcggc  1140

accaacatga tgtcctccag caagggcctg gaaatgctgg tggattccgg ctccaccttc  1200

acccacatcc ccgaggacct gtacaacaag ctcaactact tcttcgacat cctgtgcatc  1260

caagacatga acaacgccta cgacgtgaac aagcgtctga agatgaccaa cgagtccttc  1320

aacaaccccc tggtgcagtt cgacgatttc cgcaagtccc tgaagtccat catcgccaag  1380

gaaaatatgt gcgtgaagat cgtggacggc gtgcagtgct ggaagtacct ggaaggcctg  1440

cccgacctgt tcgtgaccct gtctaacaac tacaagatga agtggcagcc ccactcctac  1500

ctctacaaga aggaatcttt ctggtgcaag ggcatcgaga agcaagtcaa caacaagcct  1560

atcctgggcc tgaccttctt caagaaccgt caagtgatct tcgatatcca gaagaaccgc  1620

atcggtttcg tggacgctaa ctgcccctcc caccctaccc acactcgtcc tagataataa  1680

ctcgag                                                                1686


<210>  4
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Geneart synthetic gene with KPNI and XhoI restrictiion sites for 
       insertion into pTriex2 vector

<400>  4
ggtacccgtt ccgagtctac cgagggccac tccaaggacc tgctgtacaa gtacaagctg    60

tacggcgaca tcgacgagta cgcttactac ttcctggaca tcgacatcgg cacccccgag   120

cagcgcatct ccctgatcct ggataccggt tcctccagcc tgtccttccc ttgcgctggt   180

tgcaagaact gcggtgtcca catggaaaac cccttcaacc tgaacaactc caagacctcc   240

tccatcctgt actgcgagaa cgaggaatgc cctttcaagc tgaactgcgt gaagggcaag   300

tgcgagtaca tgcagtccta ctgcgagggt tcccagatct ccggtttcta cttctccgac   360

gtggtgtccg tcgtgtccta caacaacgag cgtgtgacct tccgcaagct gatgggttgc   420

cacatgcacg aagagtccct gttcctctac cagcaagcta ccggcgtgct gggcatgtcc   480

ctgtccaagc ctcagggtat ccccaccttc gtgaacctgc tgttcgacaa cgctccccag   540

ctgaagcaag tgttcaccat ctgcatctcc gagaacggtg gcgagctgat cgctggtggt   600

tacgaccccg cttacatcgt gcgtcgtggt ggttccaagt ccgtgtccgg ccagggttct   660

ggtcctgtgt ccgagtctct gtctgagtcc ggcgaggacc cccaagtggc tctgagggaa   720

gctgagaagg tcgtgtggga gaacgtgacc cgcaagtact actactacat caaagtgcgc   780

ggcctggaca tgttcggcac caacatgatg tcctccagca agggcctgga aatgctggtg   840

gattccggct ccaccttcac ccacatcccc gaggacctgt acaacaagct caactacttc   900

ttcgacatcc tgtgcatcca agacatgaac aacgcctacg acgtgaacaa gcgtctgaag   960

atgaccaacg agtccttcaa caaccccctg gtgcagttcg acgatttccg caagtccctg  1020

aagtccatca tcgccaagga aaatatgtgc gtgaagatcg tggacggcgt gcagtgctgg  1080

aagtacctgg aaggcctgcc cgacctgttc gtgaccctgt ctaacaacta caagatgaag  1140

tggcagcccc actcctacct ctacaagaag gaatctttct ggtgcaaggg catcgagaag  1200

caagtcaaca acaagcctat cctgggcctg accttcttca agaaccgtca agtgatcttc  1260

gatatccaga agaaccgcat cggtttcgtg gacgctaact gcccctccca ccctacccac  1320

actcgtccta gataataact cgag                                         1344


<210>  5
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant P. vivax plasmepsin V including an N-terminal gp67 
       signal peptide, and a fusion tag comprised of a FLAG tag, SUMO 
       domain and tobacco etch virus (TEV) protease cleavage site

<400>  5

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Leu Gln Asp Ser Glu Val 
1               5                   10                  15      

Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr 
            20                  25                  30          

His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys 
        35                  40                  45              

Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys 
    50                  55                  60                  

Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr Asp Gly Ile 
65                  70                  75                  80  

Glu Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn 
                85                  90                  95      

Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Glu Asn Leu Tyr 
            100                 105                 110         

Phe Gln Gly Thr Arg Ser Glu Ser Thr Glu Gly His Ser Lys Asp Leu 
        115                 120                 125             

Leu Tyr Lys Tyr Lys Leu Tyr Gly Asp Ile Asp Glu Tyr Ala Tyr Tyr 
    130                 135                 140                 

Phe Leu Asp Ile Asp Ile Gly Thr Pro Glu Gln Arg Ile Ser Leu Ile 
145                 150                 155                 160 

Leu Asp Thr Gly Ser Ser Ser Leu Ser Phe Pro Cys Ala Gly Cys Lys 
                165                 170                 175     

Asn Cys Gly Val His Met Glu Asn Pro Phe Asn Leu Asn Asn Ser Lys 
            180                 185                 190         

Thr Ser Ser Ile Leu Tyr Cys Glu Asn Glu Glu Cys Pro Phe Lys Leu 
        195                 200                 205             

Asn Cys Val Lys Gly Lys Cys Glu Tyr Met Gln Ser Tyr Cys Glu Gly 
    210                 215                 220                 

Ser Gln Ile Ser Gly Phe Tyr Phe Ser Asp Val Val Ser Val Val Ser 
225                 230                 235                 240 

Tyr Asn Asn Glu Arg Val Thr Phe Arg Lys Leu Met Gly Cys His Met 
                245                 250                 255     

His Glu Glu Ser Leu Phe Leu Tyr Gln Gln Ala Thr Gly Val Leu Gly 
            260                 265                 270         

Met Ser Leu Ser Lys Pro Gln Gly Ile Pro Thr Phe Val Asn Leu Leu 
        275                 280                 285             

Phe Asp Asn Ala Pro Gln Leu Lys Gln Val Phe Thr Ile Cys Ile Ser 
    290                 295                 300                 

Glu Asn Gly Gly Glu Leu Ile Ala Gly Gly Tyr Asp Pro Ala Tyr Ile 
305                 310                 315                 320 

Val Arg Arg Gly Gly Ser Lys Ser Val Ser Gly Gln Gly Ser Gly Pro 
                325                 330                 335     

Val Ser Glu Ser Leu Ser Glu Ser Gly Glu Asp Pro Gln Val Ala Leu 
            340                 345                 350         

Arg Glu Ala Glu Lys Val Val Trp Glu Asn Val Thr Arg Lys Tyr Tyr 
        355                 360                 365             

Tyr Tyr Ile Lys Val Arg Gly Leu Asp Met Phe Gly Thr Asn Met Met 
    370                 375                 380                 

Ser Ser Ser Lys Gly Leu Glu Met Leu Val Asp Ser Gly Ser Thr Phe 
385                 390                 395                 400 

Thr His Ile Pro Glu Asp Leu Tyr Asn Lys Leu Asn Tyr Phe Phe Asp 
                405                 410                 415     

Ile Leu Cys Ile Gln Asp Met Asn Asn Ala Tyr Asp Val Asn Lys Arg 
            420                 425                 430         

Leu Lys Met Thr Asn Glu Ser Phe Asn Asn Pro Leu Val Gln Phe Asp 
        435                 440                 445             

Asp Phe Arg Lys Ser Leu Lys Ser Ile Ile Ala Lys Glu Asn Met Cys 
    450                 455                 460                 

Val Lys Ile Val Asp Gly Val Gln Cys Trp Lys Tyr Leu Glu Gly Leu 
465                 470                 475                 480 

Pro Asp Leu Phe Val Thr Leu Ser Asn Asn Tyr Lys Met Lys Trp Gln 
                485                 490                 495     

Pro His Ser Tyr Leu Tyr Lys Lys Glu Ser Phe Trp Cys Lys Gly Ile 
            500                 505                 510         

Glu Lys Gln Val Asn Asn Lys Pro Ile Leu Gly Leu Thr Phe Phe Lys 
        515                 520                 525             

Asn Arg Gln Val Ile Phe Asp Ile Gln Lys Asn Arg Ile Gly Phe Val 
    530                 535                 540                 

Asp Ala Asn Cys Pro Ser His Pro Thr His Thr Arg Pro Arg 
545                 550                 555             


<210>  6
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant P. vivax plasmepsin V after TEV cleavage (residues 35
       to 476)

<400>  6

Gly Thr Arg Ser Glu Ser Thr Glu Gly His Ser Lys Asp Leu Leu Tyr 
1               5                   10                  15      

Lys Tyr Lys Leu Tyr Gly Asp Ile Asp Glu Tyr Ala Tyr Tyr Phe Leu 
            20                  25                  30          

Asp Ile Asp Ile Gly Thr Pro Glu Gln Arg Ile Ser Leu Ile Leu Asp 
        35                  40                  45              

Thr Gly Ser Ser Ser Leu Ser Phe Pro Cys Ala Gly Cys Lys Asn Cys 
    50                  55                  60                  

Gly Val His Met Glu Asn Pro Phe Asn Leu Asn Asn Ser Lys Thr Ser 
65                  70                  75                  80  

Ser Ile Leu Tyr Cys Glu Asn Glu Glu Cys Pro Phe Lys Leu Asn Cys 
                85                  90                  95      

Val Lys Gly Lys Cys Glu Tyr Met Gln Ser Tyr Cys Glu Gly Ser Gln 
            100                 105                 110         

Ile Ser Gly Phe Tyr Phe Ser Asp Val Val Ser Val Val Ser Tyr Asn 
        115                 120                 125             

Asn Glu Arg Val Thr Phe Arg Lys Leu Met Gly Cys His Met His Glu 
    130                 135                 140                 

Glu Ser Leu Phe Leu Tyr Gln Gln Ala Thr Gly Val Leu Gly Met Ser 
145                 150                 155                 160 

Leu Ser Lys Pro Gln Gly Ile Pro Thr Phe Val Asn Leu Leu Phe Asp 
                165                 170                 175     

Asn Ala Pro Gln Leu Lys Gln Val Phe Thr Ile Cys Ile Ser Glu Asn 
            180                 185                 190         

Gly Gly Glu Leu Ile Ala Gly Gly Tyr Asp Pro Ala Tyr Ile Val Arg 
        195                 200                 205             

Arg Gly Gly Ser Lys Ser Val Ser Gly Gln Gly Ser Gly Pro Val Ser 
    210                 215                 220                 

Glu Ser Leu Ser Glu Ser Gly Glu Asp Pro Gln Val Ala Leu Arg Glu 
225                 230                 235                 240 

Ala Glu Lys Val Val Trp Glu Asn Val Thr Arg Lys Tyr Tyr Tyr Tyr 
                245                 250                 255     

Ile Lys Val Arg Gly Leu Asp Met Phe Gly Thr Asn Met Met Ser Ser 
            260                 265                 270         

Ser Lys Gly Leu Glu Met Leu Val Asp Ser Gly Ser Thr Phe Thr His 
        275                 280                 285             

Ile Pro Glu Asp Leu Tyr Asn Lys Leu Asn Tyr Phe Phe Asp Ile Leu 
    290                 295                 300                 

Cys Ile Gln Asp Met Asn Asn Ala Tyr Asp Val Asn Lys Arg Leu Lys 
305                 310                 315                 320 

Met Thr Asn Glu Ser Phe Asn Asn Pro Leu Val Gln Phe Asp Asp Phe 
                325                 330                 335     

Arg Lys Ser Leu Lys Ser Ile Ile Ala Lys Glu Asn Met Cys Val Lys 
            340                 345                 350         

Ile Val Asp Gly Val Gln Cys Trp Lys Tyr Leu Glu Gly Leu Pro Asp 
        355                 360                 365             

Leu Phe Val Thr Leu Ser Asn Asn Tyr Lys Met Lys Trp Gln Pro His 
    370                 375                 380                 

Ser Tyr Leu Tyr Lys Lys Glu Ser Phe Trp Cys Lys Gly Ile Glu Lys 
385                 390                 395                 400 

Gln Val Asn Asn Lys Pro Ile Leu Gly Leu Thr Phe Phe Lys Asn Arg 
                405                 410                 415     

Gln Val Ile Phe Asp Ile Gln Lys Asn Arg Ile Gly Phe Val Asp Ala 
            420                 425                 430         

Asn Cys Pro Ser His Pro Thr His Thr Arg Pro Arg 
        435                 440                 


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide from knob-associated histidine-rich protein (KAHRP) 
       containing PEXEL sequence RTLAQ

<400>  7

Asp Ala Asx Cys Tyr Leu Arg Asn Lys Arg Thr Leu Ala Gln Lys Gln 
1               5                   10                  15      

Glu Glu Asp Ala Asn Ser 
            20          


<210>  8
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide from knob-associated histidine-rich protein (KAHRP) 
       containing PEXEL variant sequence KTLAQ

<400>  8

Asp Ala Asx Cys Tyr Leu Arg Asn Lys Lys Thr Leu Ala Gln Lys Gln 
1               5                   10                  15      

Glu Glu Asp Ala Asn Ser 
            20          


<210>  9
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide from knob-associated histidine-rich protein (KAHRP) 
       containing variant PEXEL sequence RTIAQ

<400>  9

Asp Ala Asx Cys Tyr Leu Arg Asn Lys Arg Thr Ile Ala Gln Lys Gln 
1               5                   10                  15      
Glu Glu Asp Ala Asn Ser 
            20          




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