                         SEQUENCE LISTING

<110>  New York University
       Janssen Biotech, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR ANTI-STAPHYLOCOCCAL BIOLOGIC AGENTS

<130>  29527.1741

<140>  PCT/US16/35931
<141>  2016-06-04

<150>  US 62/171,788
<151>  2015-06-05

<160>  1243  

<170>  PatentIn version 3.5

<210>  1
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Tencon-25

<400>  1

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  2
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  3
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Tencon  BC loop

<400>  3

Thr Ala Pro Asp Ala Ala 
1               5       


<210>  4
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Tencon FG loop

<400>  4

Lys Gly Gly His Arg Ser Asn 
1               5           


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  POP2222

<400>  5
cggcggttag aacgcggcta c                                                 21


<210>  6
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  POP2250

<400>  6
cggcggttag aacgcggcta caattaatac                                        30


<210>  7
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  DidLigRev

<400>  7
catgattacg ccaagctcag aa                                                22


<210>  8
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  MDD40

<400>  8
agccgccgcc accggttaat ggtgatggtg atggtgacca ccggtggtga agatcgcaga       60

cag                                                                     63


<210>  9
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  MDD62

<400>  9
aagaaggaga accggtatgc tgccggcgcc gaaaaacctg gttgtttctc gtgttacc         58


<210>  10
<211>  330
<212>  PRT
<213>  S. aureus

<400>  10

His His His His His His Asn Ser Ala His Lys Asp Ser Gln Asp Gln 
1               5                   10                  15      


Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn 
            20                  25                  30          


Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro Asp Asp Ile Gly Lys 
        35                  40                  45              


Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr 
    50                  55                  60                  


Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr 
65                  70                  75                  80  


Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly Ser Ile His Ser Asn 
                85                  90                  95      


Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys 
            100                 105                 110         


Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val Lys Arg Asn Arg Lys 
        115                 120                 125             


Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys 
    130                 135                 140                 


Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr 
145                 150                 155                 160 


Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser 
                165                 170                 175     


Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn 
            180                 185                 190         


Trp His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly 
        195                 200                 205             


Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg 
    210                 215                 220                 


Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg 
225                 230                 235                 240 


Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr 
                245                 250                 255     


Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr 
            260                 265                 270         


Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile His Tyr Ala 
        275                 280                 285             


Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu Ile Val Thr 
    290                 295                 300                 


Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val Asp Lys Tyr 
305                 310                 315                 320 


Ser Asp Asp Asn Lys Pro Tyr Lys Ala Gly 
                325                 330 


<210>  11
<211>  309
<212>  PRT
<213>  S. aureus

<400>  11

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  12
<211>  323
<212>  PRT
<213>  S. aureus

<400>  12

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Ala Gly Ser His Met Leu Ala Gln His Ile Thr Pro Val Ser Glu Lys 
            20                  25                  30          


Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr Ala Thr Ser Asp 
        35                  40                  45              


Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys 
    50                  55                  60                  


Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys Ala Ala Gly Asn 
65                  70                  75                  80  


Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp Tyr Asn Tyr Ser 
                85                  90                  95      


Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val Ser Ser Glu Ser 
            100                 105                 110         


Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys Asn Gln Asn Glu 
        115                 120                 125             


Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr Gly Gly Asp Ile 
    130                 135                 140                 


Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly Ser Lys Ser Phe 
145                 150                 155                 160 


Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg Thr Thr Ile Asp 
                165                 170                 175     


Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val Glu Ala His Lys 
            180                 185                 190         


Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp Ser Tyr Asp Pro 
        195                 200                 205             


Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln Ser Ser Ser Asn 
    210                 215                 220                 


Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro Leu Leu Ala Arg 
225                 230                 235                 240 


Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser His Lys Gln Asn 
                245                 250                 255     


Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln Arg Glu Met Asp 
            260                 265                 270         


Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Val Gly Asn Asn Tyr 
        275                 280                 285             


Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr Glu Val Asp Trp 
    290                 295                 300                 


Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser Lys Glu Thr Asn 
305                 310                 315                 320 


Pro Gly Val 
            


<210>  13
<211>  305
<212>  PRT
<213>  S. aureus

<400>  13

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Ala Gly Ser His Met Leu Asn Thr Asn Ile Glu Asn Ile Gly Asp Gly 
            20                  25                  30          


Ala Glu Val Ile Lys Arg Thr Glu Asp Val Ser Ser Lys Lys Trp Gly 
        35                  40                  45              


Val Thr Gln Asn Val Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn 
    50                  55                  60                  


Lys Asp Ala Leu Ile Val Lys Met Gln Gly Phe Ile Asn Ser Arg Thr 
65                  70                  75                  80  


Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr Glu Leu Thr Lys Arg Met 
                85                  90                  95      


Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr Thr Lys Asp Pro Asn 
            100                 105                 110         


Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Glu Thr Thr Asp 
        115                 120                 125             


Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala 
    130                 135                 140                 


Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser Lys Thr Ile Ser 
145                 150                 155                 160 


Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val Asp Lys Gln Asn Ser Lys 
                165                 170                 175     


Ser Val Lys Trp Gly Val Lys Ala Asn Glu Phe Val Thr Pro Asp Gly 
            180                 185                 190         


Lys Lys Ser Ala His Asp Arg Tyr Leu Phe Val Gln Ser Pro Asn Gly 
        195                 200                 205             


Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala Pro Asp Asn Gln Leu Pro 
    210                 215                 220                 


Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser 
225                 230                 235                 240 


His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe Glu Ile Ser Tyr Gly 
                245                 250                 255     


Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu Phe Pro Arg Thr Gly Ile 
            260                 265                 270         


Tyr Ala Glu Arg Lys His Asn Ala Phe Val Asn Arg Asn Phe Val Val 
        275                 280                 285             


Arg Tyr Glu Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly His 
    290                 295                 300                 


Asn 
305 


<210>  14
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17 LukAB binding FN3 domain

<400>  14

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  15
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk19 LukAB binding FN3 domain

<400>  15

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr His Ala Ile His Arg Leu Asn His Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Ala Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Pro Asp 
65                  70                  75                  80  


Ala Phe Val Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  16
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk20 LukAB binding FN3 domain

<400>  16

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr His Ala Ile His Arg Leu Asn His Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Pro Asp 
65                  70                  75                  80  


Ala Phe Val Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  17
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk24 LukAB binding FN3 domain

<400>  17

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Gly Tyr Phe Glu Leu Trp Pro Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Glu Val Phe Ile Arg Gly Val Lys Gly Gly Leu Tyr Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  18
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk8 LukD binding FN3 domain

<400>  18

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Lys Pro Trp Ala Pro Ile Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Asp His Ala 
65                  70                  75                  80  


Gly Pro Lys Tyr Glu Ile Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  19
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk9 LukD binding FN3 domain

<400>  19

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Arg Thr Tyr Ser Leu Leu Asn Tyr Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Gly Gln 
65                  70                  75                  80  


His Pro Thr Tyr Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  20
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk10 LukD binding FN3 domain

<400>  20

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Ala Ser Glu Asn Ala Phe Val Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Gly Lys Leu 
65                  70                  75                  80  


His Asn Gln Phe Glu Trp Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  21
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk11 LukD binding FN3 domain

<400>  21

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Ala Lys Pro Trp Ala Pro Lys Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Ala Ile Lys 
65                  70                  75                  80  


Pro Gly His Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  22
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk12 LukD binding FN3 domain

<400>  22

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Ala Lys Pro Trp Ala Pro Lys Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Ala Ser Glu 
65                  70                  75                  80  


Lys Phe Ile Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  23
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk21 LukD binding FN3 domain

<400>  23

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Thr Lys Pro Trp Ala Glu Tyr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Asp His Ala 
65                  70                  75                  80  


Gly Pro Lys Tyr Glu Ile Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  24
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk22 LukD binding FN3 domain

<400>  24

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Ala Lys Pro Trp Ala Pro Lys Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Ala Val Ser Ile Tyr Gly Val Lys Ala Ser Glu 
65                  70                  75                  80  


Lys Phe Ile Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  25
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26 LukE binding FN3 domain

<400>  25

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  26
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27 LukE binding FN3 domain

<400>  26

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  27
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk28 LukE binding FN3 domain

<400>  27

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Gln Tyr Trp Glu Trp Trp Pro Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Ile Ile Leu Gly Val Lys Gly Gly Trp Tyr Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  28
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk29 LukE binding FN3 domain

<400>  28

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Glu Gln Phe Val Ser Asn Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Phe Val Pro Trp Asp 
65                  70                  75                  80  


Gly Phe Ser Glu Ile Asn Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  29
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk30 LukE binding FN3 domain

<400>  29

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Phe Asn Trp Asn Tyr Phe Ala Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Ala Leu Asn 
65                  70                  75                  80  


Thr Gly Asn Lys Lys Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  30
<211>  99
<212>  PRT
<213>  Artificial

<220>
<223>  Luk31 LukE binding FN3 domain

<400>  30

Leu Pro Ala Pro Asn Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Trp Asp Lys Tyr Tyr Thr Asn Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Val Arg 
65                  70                  75                  80  


Asp Tyr Ile Arg Ala Ala Glu Trp Tyr Ser Asn Pro Leu Ser Ala Ile 
                85                  90                  95      


Phe Thr Thr 
            


<210>  31
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk32 LukE binding FN3 domain

<400>  31

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr His Glu Asn Ala Tyr Leu Leu Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Tyr Asp Leu 
65                  70                  75                  80  


Thr Pro Glu Lys Arg Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  32
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk33 LukE binding FN3 domain

<400>  32

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Phe Ile Pro Asp Glu 
65                  70                  75                  80  


Ile Glu Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  33
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk34 LukE binding FN3 domain

<400>  33

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Pro Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Val Val Pro His Glu 
65                  70                  75                  80  


Phe Glu Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  34
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk35 LukE binding FN3 domain

<400>  34

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala His Ile Pro Trp Glu 
65                  70                  75                  80  


Phe Glu Trp Ser Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  35
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk36 LukE binding FN3 domain

<400>  35

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Asp Val Pro Asp Glu 
65                  70                  75                  80  


Tyr Glu Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  36
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk37 LukE binding FN3 domain

<400>  36

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Gly Trp Pro Leu Phe 
65                  70                  75                  80  


Ile Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  37
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38 LukE binding FN3 domain

<400>  37

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  38
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk39 LukE binding FN3 domain

<400>  38

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Val Phe Tyr Phe Ser 
65                  70                  75                  80  


Val Glu Pro Thr Trp Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  39
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk40 LukE binding FN3 domain

<400>  39

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Tyr Ala Gly Glu Pro 
65                  70                  75                  80  


Leu Leu Trp Ile Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  40
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk41 LukE binding FN3 domain

<400>  40

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Glu Val Pro Tyr Ser 
65                  70                  75                  80  


Glu Tyr Trp Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  41
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk42 LukE binding FN3 domain

<400>  41

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Trp Gly Tyr Arg Leu 
65                  70                  75                  80  


Thr Thr Glu His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  42
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk43 LukE binding FN3 domain

<400>  42

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asn Ser Phe Gly Arg Pro 
65                  70                  75                  80  


Thr Leu Asn Leu Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  43
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk44 LukE binding FN3 domain

<400>  43

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Trp Leu Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Thr Leu Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  44
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk45 LukE binding FN3 domain

<400>  44

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Trp Leu Thr Asn Ala 
65                  70                  75                  80  


Tyr Glu Trp Glu Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  45
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk46 LukE binding FN3 domain

<400>  45

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile His Tyr Glu Glu Ser Thr Trp Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Val Ile Val Gly Val Lys Gly Gly Leu Lys Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  46
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk47 LukE binding FN3 domain

<400>  46

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Gln Tyr Phe Glu Thr Thr Glu Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Ser Gly Val Lys Gly Gly Pro Leu Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  47
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk48 LukE binding FN3 domain

<400>  47

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Gly Glu Trp Trp Pro Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Leu Ile Val Gly Val Lys Gly Gly Phe Arg Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  48
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk49 LukE binding FN3 domain

<400>  48

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Val Tyr Ala Glu His Trp Pro Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asn Val Thr Ile Pro Gly Val Lys Gly Gly Lys Tyr Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  49
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk50 LukE binding FN3 domain

<400>  49

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Pro Tyr Ser Glu Trp Trp Pro Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Tyr Ile Val Gly Val Lys Gly Gly Thr Trp Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  50
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk51 LukE binding FN3 domain

<400>  50

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile His Tyr Phe Glu Ser Glu Pro Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Ile Gly Val Lys Gly Gly Trp Ser Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  51
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk52 LukE binding FN3 domain

<400>  51

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gln Tyr Gly Glu Ala Gln Glu Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Phe Ile Thr Gly Val Lys Gly Gly Asn Lys Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  52
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk53 LukE binding FN3 domain

<400>  52

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Gln Tyr Phe Glu Ala Glu Ala Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Phe Ile Val Gly Val Lys Gly Gly His Ser Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  53
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk54 LukE binding FN3 domain

<400>  53

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Val Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Glu Tyr Ser Glu Trp Trp Pro Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Val Ile Ala Gly Val Lys Gly Gly Gly Tyr Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  54
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk55 LukE binding FN3 domain

<400>  54

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gln Tyr Phe Glu Ser Ala Gly Glu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Phe Ile Val Gly Val Lys Gly Gly Val Pro Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  55
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk56 LukE binding FN3 domain

<400>  55

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Gln Tyr Ile Glu Leu Glu Ile Gly Glu Ala Ile Val Leu Thr Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Gly Val Phe Ile Ser Gly Val Lys Gly Gly Trp Asn Ser Tyr 
65                  70                  75                  80  


Pro Leu Ser Ala Ile Phe Thr Thr 
                85              


<210>  56
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk57 LukE binding FN3 domain

<400>  56

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asn Ser Phe Tyr 
            20                  25                  30          


Ile Glu Tyr Phe Glu Trp Phe Pro Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Ile Ile His Gly Val Lys Gly Gly Gln Arg Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  57
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk58 LukE binding FN3 domain

<400>  57

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Glu Tyr Asp Glu Ser Ala His Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Phe Ile Tyr Gly Val Lys Gly Gly Tyr Ala Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  58
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk59 LukE binding FN3 domain

<400>  58

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Ser Tyr Asn Glu Phe Ala Trp Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Tyr Ile His Gly Val Lys Gly Gly Pro Thr Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  59
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk60 LukE binding FN3 domain

<400>  59

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Gln Tyr Trp Glu Trp Trp Pro Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Ile Ile Leu Gly Val Lys Gly Gly Phe Arg Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  60
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  61
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  62
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  62

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  63
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  63

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  64
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  65
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  66
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  66

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  67
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  67

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  68
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 LC-D Heavy Chain

<400>  68

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  69
<211>  328
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 LC-D Light Chain

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn 
225                 230                 235                 240 


Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Arg 
                245                 250                 255     


Ala Lys Pro Trp Ala Pro Lys Phe Asp Ser Phe Leu Ile Gln Tyr Gln 
            260                 265                 270         


Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
        275                 280                 285             


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr 
    290                 295                 300                 


Val Ser Ile Tyr Gly Val Lys Ala Ser Glu Lys Phe Ile Glu Ser Asn 
305                 310                 315                 320 


Pro Leu Ser Ala Ile Phe Thr Thr 
                325             


<210>  70
<211>  559
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 HC-AB Heavy Chain

<400>  70

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  71
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 HC-AB Light Chain

<400>  71

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  72
<211>  559
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 LC-D HC-AB Heavy Chain

<400>  72

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  73
<211>  328
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 LC-D HC-AB Light Chain

<400>  73

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn 
225                 230                 235                 240 


Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Arg 
                245                 250                 255     


Ala Lys Pro Trp Ala Pro Lys Phe Asp Ser Phe Leu Ile Gln Tyr Gln 
            260                 265                 270         


Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
        275                 280                 285             


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr 
    290                 295                 300                 


Val Ser Ile Tyr Gly Val Lys Ala Ser Glu Lys Phe Ile Glu Ser Asn 
305                 310                 315                 320 


Pro Leu Ser Ala Ile Phe Thr Thr 
                325             


<210>  74
<211>  563
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 HC-D Heavy Chain

<400>  74

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Arg Ala Lys Pro Trp Ala 
                485                 490                 495     


Pro Lys Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly 
    530                 535                 540                 


Val Lys Ala Ser Glu Lys Phe Ile Glu Ser Asn Pro Leu Ser Ala Ile 
545                 550                 555                 560 


Phe Thr Thr 
            


<210>  75
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 HC-D Light Chain

<400>  75

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  76
<211>  673
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 HC AB-D Heavy Chain

<400>  76

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Arg Ala Lys Pro Trp Ala Pro Lys 
        595                 600                 605             


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys 
                645                 650                 655     


Ala Ser Glu Lys Phe Ile Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr 
            660                 665                 670         


Thr 
    


<210>  77
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 HC AB-D Light Chain

<400>  77

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  78
<211>  673
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 HC D-AB Heavy Chain

<400>  78

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Arg Ala Lys Pro Trp Ala 
                485                 490                 495     


Pro Lys Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly 
    530                 535                 540                 


Val Lys Ala Ser Glu Lys Phe Ile Glu Ser Asn Pro Leu Ser Ala Ile 
545                 550                 555                 560 


Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val 
            580                 585                 590         


Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro 
        595                 600                 605             


Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr 
    610                 615                 620                 


Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr 
625                 630                 635                 640 


Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val 
                645                 650                 655     


Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr 
            660                 665                 670         


Thr 
    


<210>  79
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  CR5133 PRASA A6 HC D-AB Light Chain

<400>  79

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  80
<211>  376
<212>  DNA
<213>  Artificial

<220>
<223>  BC6


<220>
<221>  misc_feature
<222>  (198)..(215)
<223>  n is a, c, g, or t

<400>  80
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctgaagtt accgaagact      180

ctctgcgtct gtcttggnnn nnnnnnnnnn nnnnnttyga ctctttcctg atccagtacc      240

aggaatctga aaaagttggt gaagcgatca acctgaccgt tccgggttct gaacgttctt      300

acgacctgac cggtctgaaa ccgggtaccg aatacaccgt ttctatctac ggtgttctta      360

gaagcttccc aaaggc                                                      376


<210>  81
<211>  379
<212>  DNA
<213>  Artificial

<220>
<223>  BC7


<220>
<221>  misc_feature
<222>  (198)..(218)
<223>  n is a, c, g, or t

<400>  81
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctgaagtt accgaagact      180

ctctgcgtct gtcttggnnn nnnnnnnnnn nnnnnnnntt ygactctttc ctgatccagt      240

accaggaatc tgaaaaagtt ggtgaagcga tcaacctgac cgttccgggt tctgaacgtt      300

cttacgacct gaccggtctg aaaccgggta ccgaatacac cgtttctatc tacggtgttc      360

ttagaagctt cccaaaggc                                                   379


<210>  82
<211>  382
<212>  DNA
<213>  Artificial

<220>
<223>  BC8


<220>
<221>  misc_feature
<222>  (198)..(221)
<223>  n is a, c, g, or t

<400>  82
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctgaagtt accgaagact      180

ctctgcgtct gtcttggnnn nnnnnnnnnn nnnnnnnnnn nttygactct ttcctgatcc      240

agtaccagga atctgaaaaa gttggtgaag cgatcaacct gaccgttccg ggttctgaac      300

gttcttacga cctgaccggt ctgaaaccgg gtaccgaata caccgtttct atctacggtg      360

ttcttagaag cttcccaaag gc                                               382


<210>  83
<211>  385
<212>  DNA
<213>  Artificial

<220>
<223>  BC9


<220>
<221>  misc_feature
<222>  (198)..(224)
<223>  n is a, c, g, or t

<400>  83
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctgaagtt accgaagact      180

ctctgcgtct gtcttggnnn nnnnnnnnnn nnnnnnnnnn nnnnttygac tctttcctga      240

tccagtacca ggaatctgaa aaagttggtg aagcgatcaa cctgaccgtt ccgggttctg      300

aacgttctta cgacctgacc ggtctgaaac cgggtaccga atacaccgtt tctatctacg      360

gtgttcttag aagcttccca aaggc                                            385


<210>  84
<211>  131
<212>  DNA
<213>  Artificial

<220>
<223>  130mer-L17A

<400>  84
cggcggttag aacgcggcta caattaatac ataaccccat ccccctgttg acaattaatc       60

atcggctcgt ataatgtgtg gaattgtgag cggataacaa tttcacacag gaaacaggat      120

ctaccatgct g                                                           131


<210>  85
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  POP2222ext

<400>  85
cggcggttag aacgcggcta caattaatac                                        30


<210>  86
<211>  81
<212>  DNA
<213>  Artificial

<220>
<223>  LS1114

<400>  86
ccaagacaga cgggcagagt cttcggtaac gcgagaaaca accaggtttt tcggcgccgg       60

cagcatggta gatcctgttt c                                                 81


<210>  87
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  LS1115

<400>  87
ccgaagactc tgcccgtctg tcttgg                                            26


<210>  88
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  LS1117

<400>  88
cagtggtctc acggattcct ggtactggat caggaaagag tcgaa                       45


<210>  89
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  SDG10

<400>  89
catgcggtct cttccgaaaa agttggtgaa gcgatcgtcc tgaccgttcc gggt             54


<210>  90
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  SDG24

<400>  90
ggtggtgaag atcgcagaca gcgggttag                                         29


<210>  91
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  SDG28

<400>  91
aagatcagtt gcggccgcta gactagaacc gctgccaccg ccggtggtga agatcgcaga       60

c                                                                       61


<210>  92
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  TCL19


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa at position 34 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<220>
<221>  MISC_FEATURE
<222>  (38)..(41)
<223>  Xaa at positions 38-41 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa at position 68 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa at position 70 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa at position 72 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<220>
<221>  MISC_FEATURE
<222>  (78)..(79)
<223>  Xaa at positions 78-79 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Xaa at position 81 is an equal mixture of 18 amino acids (no

       cysteine or methionine

<400>  92

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  93
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  TCL19 C strand


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<400>  93

Asp Ser Phe Xaa Ile Xaa Tyr Xaa Glu 
1               5                   


<210>  94
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  TCL19 F strand


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<400>  94

Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val 
1               5                   10  


<210>  95
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  TCL19 C strand + CD loop


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (10)..(13)
<223>  Xaa at positions 10-13 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<400>  95

Asp Ser Phe Xaa Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu 
1               5                   10                  15  


<210>  96
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  TCL19 F strand + FG loop


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (14)..(15)
<223>  Xaa at positions 14-15 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<400>  96

Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
1               5                   10                  15      


Xaa 
    


<210>  97
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  TCL19 A strand + AB loop + B strand + BC loop


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa at positions 10-11 is is an equal mixture of 18 amino acids 
       (no cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (13)..(16)
<223>  Xaa at positions 13-16 is is an equal mixture of 18 amino acids 
       (no cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<400>  97

Leu Pro Ala Pro Lys Xaa Leu Xaa Val Xaa Xaa Val Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Ala Xaa Leu Xaa Trp Xaa Ala Pro Asp Ala Ala Phe 
            20                  25              


<210>  98
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  TCL19 E strand


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is an equal mixture of 18 amino acids (no 
       cysteine or methionine)

<400>  98

Xaa Tyr Xaa Leu Thr 
1               5   


<210>  99
<211>  533
<212>  PRT
<213>  S. aureus

<400>  99

Met Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15      


Pro Asp Leu Gly Thr Leu Val Pro Arg Gly Ser Met Ala Met Asn Tyr 
            20                  25                  30          


Phe Val Gly Asn Ser Leu Gly Val Asn Leu Thr Gly Ile Glu Lys Ala 
        35                  40                  45              


Ile Ile Asn Arg Leu Asn Leu Phe Lys Glu Met Gly Arg Pro Ala Gln 
    50                  55                  60                  


Cys Val Phe Leu Ser Trp Asn Arg Tyr Leu Tyr Arg Asn Ala Gln Asn 
65                  70                  75                  80  


Tyr Ile Thr Ser Ser Asp Tyr Ile Asn Met Tyr Asp Phe Phe Gln Glu 
                85                  90                  95      


Ala Thr Tyr Leu Glu Arg Asn Glu Pro Phe Asp Trp Leu Ser Tyr Trp 
            100                 105                 110         


Thr Asp Glu Cys His Tyr Thr Leu Lys His Val Glu Asn Ser His Asp 
        115                 120                 125             


Phe Arg Ile Tyr Asp Gln Glu Arg Phe Leu Met Tyr Ala His Phe Gln 
    130                 135                 140                 


Asp Pro Lys Tyr Arg Ile Leu Asp Tyr Val Asn His Phe Asp Ser Gln 
145                 150                 155                 160 


Arg Arg Lys Val Lys Arg Asp Phe Tyr Asp Val Arg Gly Phe Leu Ser 
                165                 170                 175     


Cys Ser Arg Ile Leu Val Asp Lys Gln Gln Thr Leu Cys Glu Phe Phe 
            180                 185                 190         


Tyr Asn Pro Glu Asp Asp Thr Lys Leu Glu Lys Tyr Phe Ser Tyr Lys 
        195                 200                 205             


Asp Gly Lys Pro Glu Val Gln Lys Ile Ile Val Tyr Tyr Ala Asn Lys 
    210                 215                 220                 


Gln Tyr Phe Phe Asn Asn Glu Thr Glu Leu Gly Ala Phe Phe Ile Lys 
225                 230                 235                 240 


Gln Leu Tyr Gln His Gly Asp Leu Phe Phe Ser Asp Arg Asn Val Tyr 
                245                 250                 255     


Thr Ala Pro Ile Phe Asn Leu Thr Pro Glu Ser Ile Pro Val Val Ala 
            260                 265                 270         


Val Leu His Ser Thr His Ile Lys Asn Ile Asp Ala Leu Asp Ser Ser 
        275                 280                 285             


Pro Phe Lys Asn Val Tyr Lys Ala Met Phe Glu Asn Leu Ser Arg Tyr 
    290                 295                 300                 


Arg Ala Ile Ile Val Ser Thr Glu Gln Gln Lys Leu Asp Val Glu Lys 
305                 310                 315                 320 


Arg Ile Asn His Thr Ile Pro Val Val Asn Ile Pro Val Gly Tyr Ser 
                325                 330                 335     


Glu Thr Ile Asp Thr Pro Val Gln Thr Leu Asp Gln Arg Ser Val Lys 
            340                 345                 350         


Leu Ile Ser Val Ala Arg Tyr Ser Pro Glu Lys Gln Leu His Gln Gln 
        355                 360                 365             


Ile Glu Leu Ile Lys Arg Leu Val Ser Tyr Val Pro Lys Ile Glu Leu 
    370                 375                 380                 


His Met Tyr Gly Phe Gly Ser Glu Ser Lys Lys Leu Asn Glu Leu Ile 
385                 390                 395                 400 


Gln Lys Tyr Gly Leu Glu Asn His Val Tyr Leu Arg Gly Phe Leu Ser 
                405                 410                 415     


Asn Leu Asp Gln Glu Tyr Ser Asp Ala Tyr Leu Ser Leu Ile Thr Ser 
            420                 425                 430         


Asn Met Glu Gly Phe Ser Leu Ala Leu Leu Glu Ser Leu Ala His Gly 
        435                 440                 445             


Val Pro Val Ile Ser Tyr Asp Ile Lys Tyr Gly Pro Asn Glu Leu Ile 
    450                 455                 460                 


Thr Ser Asp Phe Asn Gly Tyr Leu Ile Thr Lys Asn Asp Glu Asp Ala 
465                 470                 475                 480 


Leu Phe Asp Lys Val Lys Tyr Val Ile Asp His Pro Glu Val Gln Gln 
                485                 490                 495     


Arg Leu Ser Lys Gly Ser Leu Ala Lys Ala Gln Gln Tyr Ser Lys Ala 
            500                 505                 510         


Ser Leu Ile Lys Gln Trp Asp Gln Phe Val Arg Leu Ile Leu Glu His 
        515                 520                 525             


His His His His His 
    530             


<210>  100
<211>  868
<212>  PRT
<213>  S. aureus

<400>  100

Met Ala Glu His Thr Asn Gly Glu Leu Asn Gln Ser Lys Asn Glu Thr 
1               5                   10                  15      


Thr Ala Pro Ser Glu Asn Lys Thr Thr Lys Lys Val Asp Ser Arg Gln 
            20                  25                  30          


Leu Lys Asp Asn Thr Gln Thr Ala Thr Ala Asp Gln Pro Lys Val Thr 
        35                  40                  45              


Met Ser Asp Ser Ala Thr Val Lys Glu Thr Ser Ser Asn Met Gln Ser 
    50                  55                  60                  


Pro Gln Asn Ala Thr Ala Asn Gln Ser Thr Thr Lys Thr Ser Asn Val 
65                  70                  75                  80  


Thr Thr Asn Asp Lys Ser Ser Thr Thr Tyr Ser Asn Glu Thr Asp Lys 
                85                  90                  95      


Ser Asn Leu Thr Gln Ala Lys Asp Val Ser Thr Thr Pro Lys Thr Thr 
            100                 105                 110         


Thr Ile Lys Pro Arg Thr Leu Asn Arg Met Ala Val Asn Thr Val Ala 
        115                 120                 125             


Ala Pro Gln Gln Gly Thr Asn Val Asn Asp Lys Val His Phe Ser Asn 
    130                 135                 140                 


Ile Asp Ile Ala Ile Asp Lys Gly His Val Asn Gln Thr Thr Gly Lys 
145                 150                 155                 160 


Thr Glu Phe Trp Ala Thr Ser Ser Asp Val Leu Lys Leu Lys Ala Asn 
                165                 170                 175     


Tyr Thr Ile Asp Asp Ser Val Lys Glu Gly Asp Thr Phe Thr Phe Lys 
            180                 185                 190         


Tyr Gly Gln Tyr Phe Arg Pro Gly Ser Val Arg Leu Pro Ser Gln Thr 
        195                 200                 205             


Gln Asn Leu Tyr Asn Ala Gln Gly Asn Ile Ile Ala Lys Gly Ile Tyr 
    210                 215                 220                 


Asp Ser Thr Thr Asn Thr Thr Thr Tyr Thr Phe Thr Asn Tyr Val Asp 
225                 230                 235                 240 


Gln Tyr Thr Asn Val Arg Gly Ser Phe Glu Gln Val Ala Phe Ala Lys 
                245                 250                 255     


Arg Lys Asn Ala Thr Thr Asp Lys Thr Ala Tyr Lys Met Glu Val Thr 
            260                 265                 270         


Leu Gly Asn Asp Thr Tyr Ser Glu Glu Ile Ile Val Asp Tyr Gly Asn 
        275                 280                 285             


Lys Lys Ala Gln Pro Leu Ile Ser Ser Thr Asn Tyr Ile Asn Asn Glu 
    290                 295                 300                 


Asp Leu Ser Arg Asn Met Thr Ala Tyr Val Asn Gln Pro Lys Asn Thr 
305                 310                 315                 320 


Tyr Thr Lys Gln Thr Phe Val Thr Asn Leu Thr Gly Tyr Lys Phe Asn 
                325                 330                 335     


Pro Asn Ala Lys Asn Phe Lys Ile Tyr Glu Val Thr Asp Gln Asn Gln 
            340                 345                 350         


Phe Val Asp Ser Phe Thr Pro Asp Thr Ser Lys Leu Lys Asp Val Thr 
        355                 360                 365             


Asp Gln Phe Asp Val Ile Tyr Ser Asn Asp Asn Lys Thr Ala Thr Val 
    370                 375                 380                 


Asp Leu Met Lys Gly Gln Thr Ser Ser Asn Lys Gln Tyr Ile Ile Gln 
385                 390                 395                 400 


Gln Val Ala Tyr Pro Asp Asn Ser Ser Thr Asp Asn Gly Lys Ile Asp 
                405                 410                 415     


Tyr Thr Leu Asp Thr Asp Lys Thr Lys Tyr Ser Trp Ser Asn Ser Tyr 
            420                 425                 430         


Ser Asn Val Asn Gly Ser Ser Thr Ala Asn Gly Asp Gln Lys Lys Tyr 
        435                 440                 445             


Asn Leu Gly Asp Tyr Val Trp Glu Asp Thr Asn Lys Asp Gly Lys Gln 
    450                 455                 460                 


Asp Ala Asn Glu Lys Gly Ile Lys Gly Val Tyr Val Ile Leu Lys Asp 
465                 470                 475                 480 


Ser Asn Gly Lys Glu Leu Asp Arg Thr Thr Thr Asp Glu Asn Gly Lys 
                485                 490                 495     


Tyr Gln Phe Thr Gly Leu Ser Asn Gly Thr Tyr Ser Val Glu Phe Ser 
            500                 505                 510         


Thr Pro Ala Gly Tyr Thr Pro Thr Thr Ala Asn Val Gly Thr Asp Asp 
        515                 520                 525             


Ala Val Asp Ser Asp Gly Leu Thr Thr Thr Gly Val Ile Lys Asp Ala 
    530                 535                 540                 


Asp Asn Met Thr Leu Asp Ser Gly Phe Tyr Lys Thr Pro Lys Tyr Ser 
545                 550                 555                 560 


Leu Gly Asp Tyr Val Trp Tyr Asp Ser Asn Lys Asp Gly Lys Gln Asp 
                565                 570                 575     


Ser Thr Glu Lys Gly Ile Lys Gly Val Lys Val Thr Leu Gln Asn Glu 
            580                 585                 590         


Lys Gly Glu Val Ile Gly Thr Thr Glu Thr Asp Glu Asn Gly Lys Tyr 
        595                 600                 605             


Arg Phe Asp Asn Leu Asp Ser Gly Lys Tyr Lys Val Ile Phe Glu Lys 
    610                 615                 620                 


Pro Ala Gly Leu Thr Gln Thr Gly Thr Asn Thr Thr Glu Asp Asp Lys 
625                 630                 635                 640 


Asp Ala Asp Gly Gly Glu Val Asp Val Thr Ile Thr Asp His Asp Asp 
                645                 650                 655     


Phe Thr Leu Asp Asn Gly Tyr Tyr Glu Glu Glu Thr Ser Asp Ser Asp 
            660                 665                 670         


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
        675                 680                 685             


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
    690                 695                 700                 


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asn Ser Asp 
705                 710                 715                 720 


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
                725                 730                 735     


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
            740                 745                 750         


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
        755                 760                 765             


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
    770                 775                 780                 


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
785                 790                 795                 800 


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
                805                 810                 815     


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Asn Asp Ser Asp Ser Asp 
            820                 825                 830         


Ser Asp Ser Asp Ser Asp Ala Gly Lys His Thr Pro Ala Lys Pro Met 
        835                 840                 845             


Ser Thr Val Lys Asp Gln His Lys Thr Ala Lys Ala Leu Glu His His 
    850                 855                 860                 


His His His His 
865             


<210>  101
<211>  319
<212>  PRT
<213>  S. aureus

<400>  101

Met Thr Pro Lys Tyr Ser Leu Gly Asp Tyr Val Trp Tyr Asp Ser Asn 
1               5                   10                  15      


Lys Asp Gly Lys Gln Asp Ser Thr Glu Lys Gly Ile Lys Gly Val Lys 
            20                  25                  30          


Val Thr Leu Gln Asn Glu Lys Gly Glu Val Ile Gly Thr Thr Glu Thr 
        35                  40                  45              


Asp Glu Asn Gly Lys Tyr Arg Phe Asp Asn Leu Asp Ser Gly Lys Tyr 
    50                  55                  60                  


Lys Val Ile Phe Glu Lys Pro Ala Gly Leu Thr Gln Thr Gly Thr Asn 
65                  70                  75                  80  


Thr Thr Glu Asp Asp Lys Asp Ala Asp Gly Gly Glu Val Asp Val Thr 
                85                  90                  95      


Ile Thr Asp His Asp Asp Phe Thr Leu Asp Asn Gly Tyr Tyr Glu Glu 
            100                 105                 110         


Glu Thr Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
        115                 120                 125             


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
    130                 135                 140                 


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
145                 150                 155                 160 


Ser Asp Ser Asn Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
                165                 170                 175     


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
            180                 185                 190         


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
        195                 200                 205             


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
    210                 215                 220                 


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
225                 230                 235                 240 


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
                245                 250                 255     


Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
            260                 265                 270         


Asn Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ala Gly Lys His 
        275                 280                 285             


Thr Pro Ala Lys Pro Met Ser Thr Val Lys Asp Gln His Lys Thr Ala 
    290                 295                 300                 


Lys Ala Leu Pro Glu Thr Gly Leu Glu His His His His His His 
305                 310                 315                 


<210>  102
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  102

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Arg Gly Ala Ser Gly Ile Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  103
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  103

Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Met Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  104
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  104

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  105
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  105

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ile Ile 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  106
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  106

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  107
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  107

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ile Ile 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Leu Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  108
<211>  291
<212>  PRT
<213>  S. aureus

<400>  108

Asn Ser Ala His His His His His His Gly Ser Glu Asn Lys Ile Glu 
1               5                   10                  15      


Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr 
            20                  25                  30          


Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys 
        35                  40                  45              


Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe 
    50                  55                  60                  


Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile 
65                  70                  75                  80  


Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys 
                85                  90                  95      


Asp Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp 
            100                 105                 110         


Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe 
        115                 120                 125             


Gln Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys 
    130                 135                 140                 


Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln 
145                 150                 155                 160 


Asn Ser Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr 
                165                 170                 175     


Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp 
            180                 185                 190         


Pro Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu 
        195                 200                 205             


Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu 
    210                 215                 220                 


Ser His Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr 
225                 230                 235                 240 


Gly Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu 
                245                 250                 255     


Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val 
            260                 265                 270         


Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile 
        275                 280                 285             


Thr Pro Lys 
    290     


<210>  109
<211>  310
<212>  PRT
<213>  S. aureus

<400>  109

Asn Ser Ala His His His His His His Gly Ser Glu Gly Lys Ile Thr 
1               5                   10                  15      


Pro Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr 
            20                  25                  30          


Thr Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr 
        35                  40                  45              


Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu 
    50                  55                  60                  


Lys Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn 
65                  70                  75                  80  


Asp Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser 
                85                  90                  95      


Ile Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro 
            100                 105                 110         


Lys Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr 
        115                 120                 125             


Phe Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn 
    130                 135                 140                 


Gly Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr 
145                 150                 155                 160 


Arg Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly 
                165                 170                 175     


Val Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg 
            180                 185                 190         


Asp Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg 
        195                 200                 205             


Gln Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met 
    210                 215                 220                 


Pro Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu 
225                 230                 235                 240 


Ser His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr 
                245                 250                 255     


Gln Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp 
            260                 265                 270         


Ala Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr 
        275                 280                 285             


Tyr Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys 
    290                 295                 300                 


Glu Thr Glu Asn Asn Lys 
305                 310 


<210>  110
<211>  297
<212>  PRT
<213>  S. aureus

<400>  110

Asn Ser Ala His His His His His His Gly Ser Ala Asn Asp Thr Glu 
1               5                   10                  15      


Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr Glu Asp 
            20                  25                  30          


Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe Asp Phe 
        35                  40                  45              


Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys Met Gln 
    50                  55                  60                  


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys Thr Asn 
65                  70                  75                  80  


His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly Leu Lys 
                85                  90                  95      


Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
            100                 105                 110         


Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile Gly Gly 
        115                 120                 125             


Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe Asn Tyr 
    130                 135                 140                 


Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu Val Glu 
145                 150                 155                 160 


Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn Ser Phe 
                165                 170                 175     


Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu Phe Val 
            180                 185                 190         


Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val Pro Asp 
        195                 200                 205             


Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe Ile 
    210                 215                 220                 


Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe Glu 
225                 230                 235                 240 


Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys Arg Ser 
                245                 250                 255     


Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His Asn Ala 
            260                 265                 270         


Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp Lys Thr 
        275                 280                 285             


His Glu Ile Lys Val Lys Gly Gln Asn 
    290                 295         


<210>  111
<211>  312
<212>  PRT
<213>  S. aureus

<400>  111

Asn Ser Ala His His His His His His Gly Ser Ala Gln His Ile Thr 
1               5                   10                  15      


Pro Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr 
            20                  25                  30          


Thr Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr 
        35                  40                  45              


Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu 
    50                  55                  60                  


Lys Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr Lys Pro Asn Pro Lys 
65                  70                  75                  80  


Asp Thr Ile Ser Ser Gln Phe Tyr Trp Gly Ser Lys Tyr Asn Ile Ser 
                85                  90                  95      


Ile Asn Ser Asp Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro 
            100                 105                 110         


Lys Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Val Gly Tyr Ser 
        115                 120                 125             


Tyr Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Gly Asn 
    130                 135                 140                 


Gly Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr 
145                 150                 155                 160 


Arg Thr Ser Leu Asp Lys Arg Thr Asn Phe Lys Lys Ile Gly Trp Asp 
                165                 170                 175     


Val Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg 
            180                 185                 190         


Asp Ser Tyr His Ser Thr Tyr Gly Asn Glu Met Phe Leu Gly Ser Arg 
        195                 200                 205             


Gln Ser Asn Leu Asn Ala Gly Gln Asn Phe Leu Glu Tyr His Lys Met 
    210                 215                 220                 


Pro Val Leu Ser Arg Gly Asn Phe Asn Pro Glu Phe Ile Gly Val Leu 
225                 230                 235                 240 


Ser Arg Lys Gln Asn Ala Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr 
                245                 250                 255     


Gln Arg Glu Met Asp Arg Tyr Thr Asn Phe Trp Asn Gln Leu His Trp 
            260                 265                 270         


Ile Gly Asn Asn Tyr Lys Asp Glu Asn Arg Ala Thr His Thr Ser Ile 
        275                 280                 285             


Tyr Glu Val Asp Trp Glu Asn His Thr Val Lys Leu Ile Asp Thr Gln 
    290                 295                 300                 


Ser Lys Glu Lys Asn Pro Met Ser 
305                 310         


<210>  112
<211>  295
<212>  PRT
<213>  S. aureus

<400>  112

Asn Ser Ala His His His His His His Gly Ser Asp Asn Asn Ile Glu 
1               5                   10                  15      


Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg Thr Glu Asp Thr Ser 
            20                  25                  30          


Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln Phe Asp Phe Val Lys 
        35                  40                  45              


Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys Met Gln Gly Phe 
    50                  55                  60                  


Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys Asn Thr Asp His Ile 
65                  70                  75                  80  


Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly Leu Lys Thr Asn 
                85                  90                  95      


Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp 
            100                 105                 110         


Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn Phe 
        115                 120                 125             


Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser Phe Asn Tyr Ser Lys 
    130                 135                 140                 


Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser Glu Val Glu Arg Gln 
145                 150                 155                 160 


Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala Asn Ser Phe Ile Thr 
                165                 170                 175     


Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn Leu Phe Val Gly Tyr 
            180                 185                 190         


Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe Val Pro Asp Asn Glu 
        195                 200                 205             


Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro Ser Phe Ile Ala Thr 
    210                 215                 220                 


Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser Glu Phe Glu Ile Thr 
225                 230                 235                 240 


Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr Arg Arg Thr Thr His 
                245                 250                 255     


Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile His Asn Ala Phe Val 
            260                 265                 270         


Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu 
        275                 280                 285             


Ile Lys Val Lys Gly His Asn 
    290                 295 


<210>  113
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk82 LukE, LukF binding FN3 domain

<400>  113

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser Asn Arg Ala Ile Thr Thr Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Tyr Arg Phe Arg 
65                  70                  75                  80  


Pro Lys Tyr Thr Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  114
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk83 LukF binding FN3 domain

<400>  114

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Phe Arg Pro Ser Glu Asp Ile Ser Ser Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Phe Pro 
65                  70                  75                  80  


Thr Asp Ala Lys Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  115
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk85 LukF binding FN3 domain

<400>  115

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Asn Tyr Asn Glu Glu Ala Leu Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Cys Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Glu Ile Glu Gly Val Lys Gly Gly Pro Trp Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  116
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk86 LukE, LukF binding FN3 domain

<400>  116

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Arg Tyr Asn Glu Ile Asp Leu His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Pro Ile Ala Gly Val Lys Val Cys Ile Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  117
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk87 LukE binding FN3 domain

<400>  117

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Asn Thr Glu Pro Ser Tyr Phe Ala Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Trp Val 
65                  70                  75                  80  


Thr Trp Gly Lys Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  118
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk88 LukE binding FN3 domain

<400>  118

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Leu Glu Trp Ser Leu Ile Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Arg Ser Val Ala 
65                  70                  75                  80  


Trp Tyr Phe Leu Leu Leu Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  119
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk90 LukE binding FN3 domain

<400>  119

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Thr Tyr Pro Thr Leu Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Pro Arg Asn Ile Gln 
65                  70                  75                  80  


Pro Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  120
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk92 LukE binding FN3 domain

<400>  120

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Val Lys Trp Val Ser Tyr Gln Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Ser Ile 
65                  70                  75                  80  


Asp Glu Thr Val Gly Val Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  121
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk93 LukE, LukS binding FN3 domain

<400>  121

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Arg Ile Ser Arg Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asp Arg Glu Val Tyr Asp 
65                  70                  75                  80  


Glu Trp Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  122
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk94 LukE binding FN3 domain

<400>  122

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Arg Arg Phe Leu Leu Phe Ile Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Glu Gln 
65                  70                  75                  80  


Trp Gly Glu Ala Ser Asp Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  123
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk95 LukE binding FN3 domain

<400>  123

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gln His Ser Gln Tyr Phe Val Leu Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Tyr Arg Gln 
65                  70                  75                  80  


Trp Arg Asp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  124
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk96 LukE binding FN3 domain

<400>  124

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu His Trp Pro Ser Trp 
65                  70                  75                  80  


Trp His Leu Asn Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  125
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk97 LukE binding FN3 domain

<400>  125

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Asp Ile Ile His Ile 
65                  70                  75                  80  


Asn Ser Trp Asn Asp His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  126
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk98 LukE binding FN3 domain

<400>  126

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Arg His Ser His Glu Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Ile Trp Val Leu Lys 
65                  70                  75                  80  


Leu Asn Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  127
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk99 LukE binding FN3 domain

<400>  127

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile Ile Tyr Tyr Glu Arg His Asp Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Trp Ile Pro Gly Val Lys Gly Gly Leu Thr Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  128
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk100 LukE, LukS binding FN3 domain

<400>  128

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Thr Tyr Gly Glu Tyr Arg Ser Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Asp Ile Tyr Gly Val Lys Gly Gly Leu Phe Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  129
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk101 LukE binding FN3 domain

<400>  129

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Thr Glu Pro Glu Trp Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Arg Val Glu Ile Arg 
65                  70                  75                  80  


Ala Leu Tyr Arg Ser Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  130
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk102 LukE binding FN3 domain

<400>  130

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser His Arg Phe Trp Lys 
65                  70                  75                  80  


His Val Tyr Phe Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  131
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk103 LukE binding FN3 domain

<400>  131

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Ile Gly Leu Ser Arg Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asp Phe Ala His Gln Asp 
65                  70                  75                  80  


Phe Phe Arg Gly Tyr Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  132
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk104 LukE binding FN3 domain

<400>  132

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Trp Trp Val Val Ala 
65                  70                  75                  80  


Phe His His Ala Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  133
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk106 LukE binding FN3 domain

<400>  133

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Ala Trp Ile Phe Thr 
65                  70                  75                  80  


Lys Val Leu Asn Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  134
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk107 LukE binding FN3 domain

<400>  134

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Gly Pro Asn Ser Pro Pro Ser Gln Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Lys Trp 
65                  70                  75                  80  


Arg Thr Arg Ala His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  135
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk108 LukE binding FN3 domain

<400>  135

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Phe Tyr Tyr Tyr Leu Gly Lys Phe Gly Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Asn Trp 
65                  70                  75                  80  


Arg Trp Trp Pro Asp Asp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  136
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk109 LukE binding FN3 domain

<400>  136

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Ile Asn Arg Phe Trp 
65                  70                  75                  80  


Ala Trp Tyr Leu Ala Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  137
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk110 LukS, LukF binding FN3 domain

<400>  137

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Phe Pro Thr Phe Leu 
65                  70                  75                  80  


Asn Tyr Trp Gln Phe Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  138
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk112 HlgA binding FN3 domain

<400>  138

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Tyr Glu Phe Arg His His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Phe Trp Ile Tyr Gly Val Lys Gly Gly Gly Ser Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  139
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk113 HlgA binding FN3 domain

<400>  139

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Glu Tyr His Glu Glu Tyr Glu Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile Ala Gly Val Lys Gly Gly Lys Trp Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  140
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk114 HlgA binding FN3 domain

<400>  140

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Gln Glu Leu Pro Gln Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Trp Ile Trp Gly Val Lys Gly Gly Leu Thr Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  141
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk116 HlgA binding FN3 domain

<400>  141

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Gln Glu Tyr Pro Ala Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Trp Ile Trp Gly Val Lys Gly Gly Trp Thr Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  142
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk117 HlgA binding FN3 domain

<400>  142

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Gln Glu Thr Ile Ser Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Leu Ile Trp Gly Val Lys Gly Gly Ala Ala Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  143
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk119 HlgA binding FN3 domain

<400>  143

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Asp Tyr Phe Glu Glu Tyr Gln Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile Phe Gly Val Lys Gly Gly Ile Arg Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  144
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk120 HlgA binding FN3 domain

<400>  144

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile Asn Tyr Trp Glu Ala Tyr Ile His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile His Gly Val Lys Gly Gly Gly Asn Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  145
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk122 HlgA, LukAB binding FN3 domain

<400>  145

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Tyr Glu Phe Ala Ile Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Ser Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  146
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk123 HlgA binding FN3 domain

<400>  146

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile Asp Tyr Phe Glu Glu Tyr Ser His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile Asn Gly Val Lys Gly Gly Ile Tyr Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  147
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk124 HlgA, LukD binding FN3 domain

<400>  147

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Asp Tyr Val Glu Ser Tyr Ala Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile Trp Gly Val Lys Gly Gly Ser Leu Ser 
65                  70                  75                  80  


Tyr Pro Met Ser Ala Ile Phe Thr Thr 
                85                  


<210>  148
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk125 HlgA binding FN3 domain

<400>  148

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Ile Tyr Tyr Glu His His Asn Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Pro Ile Pro Gly Val Lys Gly Gly Trp Gln Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  149
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk126 HlgA binding FN3 domain

<400>  149

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Asp Tyr Gln Glu Trp Pro Ser Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Phe Ile His Gly Val Lys Gly Gly Trp Leu Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  150
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk128 HlgA, LukD binding FN3 domain

<400>  150

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Gln Tyr Phe Glu Glu Tyr Ala Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile Ser Gly Val Lys Gly Gly Asn Phe Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  151
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk129 HlgA binding FN3 domain

<400>  151

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Asn Tyr Pro Glu Glu Phe His Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Glu Val Trp Ile Trp Gly Val Lys Gly Gly Ser Ser Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  152
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk130 HlgA binding FN3 domain

<400>  152

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile His Tyr Leu Glu Trp Glu Val Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Glu Ile Trp Gly Val Lys Gly Gly Tyr Ser Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  153
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk132 HlgA binding FN3 domain

<400>  153

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Glu Tyr Trp Glu Trp Asp Pro Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val Phe Ile Ser Gly Val Lys Gly Gly Tyr Pro Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  154
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk133 HlgA binding FN3 domain

<400>  154

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile His Tyr Gly Glu Gly Pro Glu Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val His Ile Pro Gly Val Lys Gly Gly Trp Leu Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  155
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk134 HlgA, LukE binding FN3 domain

<400>  155

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Val Tyr Leu Glu Trp Val Val Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Asp Ile Tyr Gly Val Lys Gly Gly Trp Thr Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  156
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk136 LukAB, LukD binding FN3 domain

<400>  156

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Asp Tyr Phe Glu Glu Tyr Val Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Cys Ile Val Gly Val Lys Gly Gly Thr Pro Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  157
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk138 HlgA binding FN3 domain

<400>  157

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Trp Tyr Gln Glu Phe Glu Val Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Glu Ile Trp Gly Val Lys Gly Gly Ser His Ser 
65                  70                  75                  80  


Trp Thr Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  158
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk139 HlgA, LukAB binding FN3 domain

<400>  158

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asn Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Gly Glu Trp Glu Tyr Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Trp Ile Tyr Gly Val Lys Gly Gly Asp Ser Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  159
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk140 HlgA binding FN3 domain

<400>  159

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Gln Glu Thr Lys Lys Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Leu Ile Trp Gly Val Lys Gly Gly Thr Ala Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  160
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk143 HlgA binding FN3 domain

<400>  160

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Gln Tyr Asp Glu Arg Thr Glu Glu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Thr Ile Pro Gly Val Lys Gly Gly Trp Tyr Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  161
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk144 HlgA binding FN3 domain

<400>  161

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Asp Tyr Phe Glu Glu Trp Val Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile Gln Gly Val Lys Gly Gly Val His Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  162
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk148 HlgA binding FN3 domain

<400>  162

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Gln Glu Leu Asn Arg Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Leu Ile Trp Gly Val Lys Gly Gly Asp Ser Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  163
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk151 HlgA binding FN3 domain

<400>  163

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Thr Tyr Thr Glu Val Tyr Trp Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Thr Ile Pro Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  164
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk155 HlgA binding FN3 domain

<400>  164

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Arg Tyr Phe Glu Phe Ile Lys Pro Gly Glu Ala Ile Trp Leu Gly 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Gln Ile Arg Gly Val Lys Gly Gly Arg Glu Ser 
65                  70                  75                  80  


Tyr Pro Leu Trp Ala Asp Phe Thr Thr 
                85                  


<210>  165
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk156 HlgA binding FN3 domain

<400>  165

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile Gln Tyr His Glu Thr Arg Tyr Ser Gly Glu Ala Ile Trp Leu Trp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Tyr Ile Pro Gly Val Lys Gly Gly Asn Val Ser 
65                  70                  75                  80  


Phe Pro Leu Lys Ala His Phe Thr Thr 
                85                  


<210>  166
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk158 HlgA binding FN3 domain

<400>  166

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Ser Tyr Lys Glu Ser Gly Arg Ile Gly Glu Ala Ile Ser Leu Ile 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Tyr Ile Asn Gly Val Lys Gly Gly Ile Thr Ser 
65                  70                  75                  80  


Phe Pro Leu Asn Ala Trp Phe Thr Thr 
                85                  


<210>  167
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk159 HlgA, LukAB binding FN3 domain

<400>  167

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Asp Tyr Lys Glu Thr Gly Tyr Thr Gly Glu Ala Ile Glu Leu Glu 
        35                  40                  45              


Val Pro Gly Ser Glu His Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Thr Ile Gly Gly Val Lys Gly Gly Tyr Ser Ser 
65                  70                  75                  80  


Trp Pro Leu Val Ala Leu Phe Thr Thr 
                85                  


<210>  168
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk160 HlgA binding FN3 domain

<400>  168

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Trp Tyr Thr Glu Asn Pro Ser Leu Gly Glu Ala Ile Lys Leu Ser 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Glu Ile Trp Gly Val Lys Gly Gly Arg Gly Ser 
65                  70                  75                  80  


Val Pro Leu Phe Ala Ile Phe Thr Thr 
                85                  


<210>  169
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk163 HlgA binding FN3 domain

<400>  169

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Glu Tyr Trp Glu Pro Thr Ser Asp Gly Glu Ala Ile Ala Leu Asn 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Trp Gly Val Lys Gly Gly Pro Arg Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Trp Phe Thr Thr 
                85                  


<210>  170
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk164 HlgA binding FN3 domain

<400>  170

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Glu Tyr Gly Glu Pro Glu Lys Ile Gly Glu Ala Ile Trp Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Phe Ile Tyr Gly Val Lys Gly Gly Ala Leu Ser 
65                  70                  75                  80  


Arg Pro Leu Thr Ala Thr Ser Thr Thr 
                85                  


<210>  171
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk166 HlgA binding FN3 domain

<400>  171

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gln Tyr Phe Glu Ile Gln Pro Trp Gly Glu Ala Ile Leu Leu Asp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Ile Ile Trp Gly Val Lys Gly Gly Pro Lys Ser 
65                  70                  75                  80  


Gln Pro Leu Tyr Ala Trp Phe Thr Thr 
                85                  


<210>  172
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk167 LukD binding FN3 domain

<400>  172

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Ile Tyr Ser Glu Asp Thr Ile Pro Gly Glu Ala Ile Val Leu Trp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Gln Ile Glu Gly Val Lys Gly Gly His Glu Ser 
65                  70                  75                  80  


Phe Pro Leu Val Ala Asn Phe Thr Thr 
                85                  


<210>  173
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk174 HlgA binding FN3 domain

<400>  173

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Glu Tyr Gly Glu Pro Glu Lys Ile Gly Glu Ala Ile Trp Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Phe Ile Tyr Gly Val Lys Gly Gly Ala Leu Ser 
65                  70                  75                  80  


Arg Pro Leu Thr Ala Thr Phe Thr Thr 
                85                  


<210>  174
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk176 HlgA binding FN3 domain

<400>  174

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Tyr Tyr His Glu Phe Pro Tyr Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Arg Ile Leu Gly Val Lys Gly Gly Gly Leu Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  175
<211>  87
<212>  PRT
<213>  Artificial

<220>
<223>  Luk177 LukD binding FN3 domain

<400>  175

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Tyr Tyr Arg Glu Trp Gly Ser Gly Glu Ala Ile Val Leu Thr Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Leu Val Ile Thr Gly Val Lys Gly Gly Asn Pro Ser Tyr Pro 
65                  70                  75                  80  


Leu Ser Ala Ile Phe Thr Thr 
                85          


<210>  176
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk178 HlgA binding FN3 domain

<400>  176

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile His Tyr Phe Glu Ala Tyr Ala Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile Phe Gly Val Lys Gly Gly Leu Tyr Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  177
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk179 HlgA binding FN3 domain

<400>  177

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile Asn Tyr Phe Glu Ala Trp Asp Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Trp Ile Ser Gly Val Lys Gly Gly Arg Tyr Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  178
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk180 HlgA binding FN3 domain

<400>  178

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile His Tyr Tyr Glu Pro Ile Tyr Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Trp Ile Tyr Gly Val Lys Gly Gly Tyr Ser Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  179
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk182 HlgC binding FN3 domain

<400>  179

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Leu Tyr Ile Glu Asn Asp Trp Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  180
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk183 HlgC binding FN3 domain

<400>  180

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Trp Tyr Trp Glu Phe Leu His Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Ser Val Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  181
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk184 HlgC binding FN3 domain

<400>  181

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr His Glu Leu Asn Thr Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Pro Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  182
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk185 HlgC, LukS binding FN3 domain

<400>  182

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Val Tyr Arg Glu Trp Phe His Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  183
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk186 HlgC binding FN3 domain

<400>  183

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Thr Tyr Thr Glu Tyr Ser Phe Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  184
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk187 HlgC binding FN3 domain

<400>  184

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Leu Tyr Phe Glu Tyr Lys Arg Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  185
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk188 HlgC binding FN3 domain

<400>  185

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile His Tyr Trp Glu Phe Asn Pro Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Gly Ile Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  186
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk189 HlgC binding FN3 domain

<400>  186

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Leu Lys 
            20                  25                  30          


Ile Phe Tyr Phe Glu Phe Ile Tyr Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Thr Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  187
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk190 HlgC, LukS binding FN3 domain

<400>  187

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Phe Ser Asn Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  188
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk191 HlgC, LukS binding FN3 domain

<400>  188

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Trp Glu Trp Tyr His Gly Glu Ala Ile Val Leu Thr Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Asn Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser Leu 
65                  70                  75                  80  


Pro Leu Ser Ala Ile Phe Thr Thr 
                85              


<210>  189
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk192 HlgC binding FN3 domain

<400>  189

Leu Pro Ala Pro Lys Asn Leu Asp Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Glu Lys Pro Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  190
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk193 HlgC, LukS binding FN3 domain

<400>  190

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Phe Tyr His Glu Thr Arg Pro Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  191
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk194 HlgC binding FN3 domain

<400>  191

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Trp Glu Phe Ser Asp Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Gly Ile Tyr Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  192
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk195 HlgC, LukD binding FN3 domain

<400>  192

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Ile Tyr Tyr Glu Tyr Pro Ala Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Ile Ile His Gly Val Lys Gly Gly Phe Val Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  193
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk196 HlgC, LukS binding FN3 domain

<400>  193

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Ile Tyr Ile Glu Asn Pro Tyr Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  194
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk197 HlgC, LukS binding FN3 domain

<400>  194

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Leu Tyr Trp Glu Val Gln Ala Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  195
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk198 HlgC, LukS binding FN3 domain

<400>  195

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr Thr Glu Glu Lys Thr Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Trp Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  196
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk199 HlgC, LukS binding FN3 domain

<400>  196

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Leu Tyr Ala Glu His Ser Asn Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  197
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk201 HlgC, LukS binding FN3 domain

<400>  197

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Leu Glu His Asn Asp Glu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ala Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  198
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk202 HlgC binding FN3 domain

<400>  198

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Trp Tyr His Glu Thr Trp Arg Gly Glu Ala Ile Val Leu Thr Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Pro Val Val Ile His Gly Val Lys Gly Gly Phe Ile Ser Thr 
65                  70                  75                  80  


Pro Leu Ser Ala Ile Phe Thr Thr 
                85              


<210>  199
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk203 HlgC binding FN3 domain

<400>  199

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr Val Glu Tyr Glu Thr Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ala Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  200
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk204 HlgC binding FN3 domain

<400>  200

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Ile Tyr Trp Glu Leu Trp Ser Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  201
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk205 HlgC binding FN3 domain

<400>  201

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Leu Tyr Trp Glu Trp Val Ala Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Trp Leu Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  202
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk206 HlgC binding FN3 domain

<400>  202

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Phe Glu Gln Phe Ser Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Phe Val Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  203
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk208 HlgC binding FN3 domain

<400>  203

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Trp Tyr Trp Glu Trp Tyr His Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Leu Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Glu Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  204
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk210 HlgC, LukS binding FN3 domain

<400>  204

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Phe Tyr Phe Glu Tyr Leu Gly Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Val Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  205
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk211 HlgC binding FN3 domain

<400>  205

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr Phe Glu Trp Lys Arg Leu Gly Glu Ala Ile Val Pro Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly Pro Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  206
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk212 HlgC binding FN3 domain

<400>  206

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Leu Tyr Thr Glu Arg Glu Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly Asn Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  207
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk213 HlgC, LukS binding FN3 domain

<400>  207

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr His Glu Thr Asp Ala Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  208
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk214 HlgC binding FN3 domain

<400>  208

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile His Tyr Trp Glu Tyr Asp Ala Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ala Ile Tyr Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  209
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk215 HlgC, LukS binding FN3 domain

<400>  209

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Leu Tyr His Glu Ser Val Thr Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  210
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk216 HlgC, LukS binding FN3 domain

<400>  210

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile His Tyr Phe Glu Glu Ser Ile Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  211
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk218 HlgC binding FN3 domain

<400>  211

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Ile Tyr Trp Glu Tyr Arg Trp Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Pro Ile His Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  212
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk219 HlgC binding FN3 domain

<400>  212

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Trp Tyr Trp Val Tyr Arg Thr Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  213
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk220 HlgC, LukS binding FN3 domain

<400>  213

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Trp Glu Glu Ser Pro Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  214
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk221 HlgC, LukS, LukD, LukAB binding FN3 domain

<400>  214

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr His Glu Leu Glu His His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  215
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk222 HlgC, LukS binding FN3 domain

<400>  215

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Leu Tyr Trp Glu Glu Glu Phe Gly Glu Ala Ile Val Leu Thr Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Tyr Ile Ser Arg 
65                  70                  75                  80  


Pro Leu Ser Ala Ile Phe Thr Thr 
                85              


<210>  216
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk223 HlgC, LukS binding FN3 domain

<400>  216

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Leu Tyr Trp Glu Glu Glu Asn Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly His Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  217
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk224 HlgC, LukS binding FN3 domain

<400>  217

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Thr Glu His Gly Val Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Pro Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  218
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk225 HlgC binding FN3 domain

<400>  218

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr His Glu Phe Leu Thr Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ala Ile Tyr Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  219
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk226 HlgC binding FN3 domain

<400>  219

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Ala Glu Trp His Leu Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  220
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk227 HlgC binding FN3 domain

<400>  220

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Tyr Tyr His Glu Trp Gln Ala Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  221
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk228 HlgC, LukS binding FN3 domain

<400>  221

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Pro Tyr Tyr Glu Tyr Ala Val Phe Gly Glu Ala Thr Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  222
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk229 HlgC, LukS binding FN3 domain

<400>  222

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Phe Tyr Leu Glu Trp Asn Gln Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  223
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk230 HlgC binding FN3 domain

<400>  223

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Phe Tyr Thr Glu Ser His Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ala Ile Tyr Gly Val Lys Gly Gly Glu Phe Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  224
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk231 HlgC, LukS binding FN3 domain

<400>  224

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Leu Tyr Trp Glu Tyr Val Thr Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  225
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk233 HlgC binding FN3 domain

<400>  225

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Cys Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Gln Tyr Trp Glu Tyr Ser Gly Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Gly Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Ala Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  226
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk235 HlgC, LukAB binding FN3 domain

<400>  226

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Ile Tyr His Glu Trp Asp Lys Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  227
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk236 HlgC, LukS binding FN3 domain

<400>  227

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Phe Tyr Trp Glu Tyr Ile Leu Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ile Ile His Gly Val Lys Gly Gly His Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  228
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  Luk237 HlgC binding FN3 domain

<400>  228

Met Leu Pro Pro Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gln Ile Ile Tyr Trp Glu Tyr Ala Glu Thr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ile Val Ile Ile His Gly Val Lys Gly Gly Glu Ile 
65                  70                  75                  80  


Ser Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  229
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk238 HlgC, LukS binding FN3 domain

<400>  229

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr His Glu Thr Val Lys Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Arg Gly Gln Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  230
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk239 HlgC binding FN3 domain

<400>  230

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Ser Tyr Trp Glu Tyr Ala Val Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  231
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk240 HlgC, LukS binding FN3 domain

<400>  231

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Phe Tyr Asp Glu Glu Ala His Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  232
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk241 HlgC, LukS binding FN3 domain

<400>  232

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Tyr Tyr Phe Glu Ser Tyr Ala Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  233
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk242 HlgC, LukS binding FN3 domain

<400>  233

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr His Glu Thr Glu Val Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Ile Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  234
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk243 HlgC binding FN3 domain

<400>  234

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Met Tyr Phe Glu Phe Gln Ala Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Leu Ile His Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  235
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk244 HlgC binding FN3 domain

<400>  235

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Tyr Tyr Trp Glu Phe Leu Glu Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  236
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk245 HlgC binding FN3 domain

<400>  236

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Trp Glu Phe Arg Pro Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Phe Gly Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  237
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk246 HlgC, LukS binding FN3 domain

<400>  237

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile His Tyr Phe Glu Ala Ser Pro Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Val Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  238
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk247 HlgC, LukS binding FN3 domain

<400>  238

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr His Glu Tyr Val Gln Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  239
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk248 HlgC binding FN3 domain

<400>  239

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Ile Tyr Trp Glu Tyr Val Asp Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Pro Ile Tyr Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  240
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk249 HlgC binding FN3 domain

<400>  240

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Val Tyr Trp Glu Gln Lys Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  241
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk250 HlgC, LukS binding FN3 domain

<400>  241

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Asp Glu Trp Arg Gly Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile Gln Gly Val Lys Gly Gly Tyr Val Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  242
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk251 HlgC, LukS binding FN3 domain

<400>  242

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile His Tyr His Glu Tyr Gln Gln Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Ile Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  243
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk252 HlgC, LukS binding FN3 domain

<400>  243

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Leu Glu Trp Pro Ala Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  244
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk253 HlgC binding FN3 domain

<400>  244

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Val Tyr Trp Glu Tyr Asn Pro Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Asn Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  245
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk254 HlgC, LukS binding FN3 domain

<400>  245

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Phe Tyr Leu Glu His Asp Trp Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  246
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk255 HlgC, LukS binding FN3 domain

<400>  246

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Leu Tyr Trp Glu Tyr Glu Gln Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  247
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk257 LukD, LukAB binding FN3 domain

<400>  247

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr Ile Glu His Val Asp Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Lys Ile Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  248
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk258 HlgC binding FN3 domain

<400>  248

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Tyr Tyr Phe Glu Ser Val Asp Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Tyr Ile Tyr Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  249
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk259 HlgC, LukS binding FN3 domain

<400>  249

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Ile Tyr Trp Glu Ser Gln Tyr Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Val Ile His Gly Val Lys Gly Gly Gly Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  250
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk260 HlgC, LukS binding FN3 domain

<400>  250

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Ile Tyr Tyr Glu Trp Glu Ser Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  251
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk261 HlgC binding FN3 domain

<400>  251

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Phe Tyr Trp Glu Phe Gln Lys Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ile Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  252
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk262 HlgC binding FN3 domain

<400>  252

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Leu Glu Lys Thr Asn Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Pro Ile Ser 
65                  70                  75                  80  


Gly Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  253
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk263 HlgC binding FN3 domain

<400>  253

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Trp Tyr Trp Glu Tyr Val Arg Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile Tyr Gly Val Lys Gly Gly Asp Thr Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  254
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk264 HlgC, LukS binding FN3 domain

<400>  254

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr His Glu Tyr Phe Thr Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  255
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk265 HlgC binding FN3 domain

<400>  255

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Ile Tyr Phe Glu Asn Glu Tyr Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Leu Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  256
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk266 HlgC binding FN3 domain

<400>  256

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Gly Tyr Leu Glu Asn Pro Trp Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Phe Ile Tyr Gly Val Lys Gly Gly His Ile Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  257
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk267 HlgC binding FN3 domain

<400>  257

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile His Tyr Phe Glu Tyr Glu Pro Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Trp Val Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  258
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk268 HlgC, LukS binding FN3 domain

<400>  258

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Pro Glu Tyr Ser Ala Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Val Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  259
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk269 HlgC binding FN3 domain

<400>  259

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Ile Tyr Trp Glu Tyr Glu Val Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ser Ile Gln Gly Val Lys Gly Gly Ala Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  260
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk270 HlgC binding FN3 domain

<400>  260

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Val Tyr Phe Glu His Pro Ser Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  261
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk271 HlgC binding FN3 domain

<400>  261

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Val Tyr Phe Glu Trp Ala Ala Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Ala Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  262
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk272 HlgC, LukS binding FN3 domain

<400>  262

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Phe Tyr Trp Glu Asp Thr Leu Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Ala Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  263
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk273 HlgC binding FN3 domain

<400>  263

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Asn Tyr Trp Glu Phe Gln Pro Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  264
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk274 HlgC, LukS binding FN3 domain

<400>  264

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr Trp Glu Leu Val Trp Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Cys Val Pro Ile His Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  265
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk275 HlgC, LukS, LukD binding FN3 domain

<400>  265

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Glu Glu Trp Gln Val Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Ala Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  266
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk276 HlgC binding FN3 domain

<400>  266

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile His Tyr Phe Glu Tyr Glu Ile Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ser Ile Tyr Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  267
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk277 HlgC, LukS binding FN3 domain

<400>  267

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Leu Glu Tyr Asp Gln Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Thr Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  268
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk278 HlgC, LukS binding FN3 domain

<400>  268

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Phe Tyr Trp Glu Phe Ala Val Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Val Ile His Gly Val Lys Gly Gly Val Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  269
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk279 HlgC, LukS binding FN3 domain

<400>  269

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Ile Tyr Phe Glu Phe Phe Ile Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Asp Leu Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  270
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk280 HlgC, LukS binding FN3 domain

<400>  270

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Ile Tyr Trp Glu Phe Ala Ser Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  271
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk281 HlgC, LukS binding FN3 domain

<400>  271

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Phe Glu Phe Gln Thr His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile Thr Gly Val Lys Gly Gly Trp Tyr Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  272
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk282 HlgC binding FN3 domain

<400>  272

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Ile Tyr Trp Glu Tyr Arg Thr Cys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Asn Thr Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  273
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk283 HlgC, LukS binding FN3 domain

<400>  273

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Ile Thr 
            20                  25                  30          


Ile His Tyr Phe Glu Pro His Thr Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  274
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk285 HlgC, LukS binding FN3 domain

<400>  274

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Leu Tyr Trp Glu Asn Ile Thr Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Gly Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  275
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk286 HlgC binding FN3 domain

<400>  275

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Phe Tyr Trp Glu Phe Gln Ala Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Trp Thr Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  276
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk287 HlgC binding FN3 domain

<400>  276

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Val Tyr Trp Glu Trp Gln Cys Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Phe Ile His Gly Val Lys Gly Gly Ile Thr Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  277
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk288 HlgC binding FN3 domain

<400>  277

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile His Tyr Trp Glu Pro Gln Gly Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  278
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk289 HlgC binding FN3 domain

<400>  278

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Pro Tyr Trp Glu Tyr Gln Tyr Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  279
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk290 HlgC, LukS binding FN3 domain

<400>  279

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Ile Glu Pro Gln Phe Glu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  280
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk291 HlgC, LukS binding FN3 domain

<400>  280

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Ile Tyr Trp Glu Tyr Asp Pro His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ser Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  281
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk292 HlgC binding FN3 domain

<400>  281

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Glu Tyr Trp Glu Trp Ile Asp Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  282
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk293 HlgC, LukS, LukD, LukAB binding FN3 domain

<400>  282

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Leu Tyr His Glu Trp Ser Gly Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Phe Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  283
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk294 HlgC, LukS binding FN3 domain

<400>  283

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Leu Tyr Trp Glu Thr Ala Lys Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  284
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk296 HlgC binding FN3 domain

<400>  284

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Tyr Glu Phe Lys Tyr Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  285
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk298 HlgC, LukS binding FN3 domain

<400>  285

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr Leu Glu Gly Asn Trp Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ser Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  286
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk299 HlgC, LukS, LukAB binding FN3 domain

<400>  286

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Lys 
            20                  25                  30          


Ile Phe Tyr Trp Glu Trp Pro His Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  287
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk300 HlgC binding FN3 domain

<400>  287

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ser Tyr Trp Glu Tyr Ala Gly Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  288
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk301 HlgC binding FN3 domain

<400>  288

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Ser Tyr Trp Glu Tyr Tyr Ala Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Val Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  289
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk302 HlgC, LukS binding FN3 domain

<400>  289

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Lys 
            20                  25                  30          


Ile Trp Tyr Leu Glu Thr Gly Phe Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  290
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk303 HlgC binding FN3 domain

<400>  290

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Gln Tyr Trp Glu Trp Asn Leu Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Ala Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  291
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk304 HlgC binding FN3 domain

<400>  291

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Thr Glu Leu Tyr Glu Phe Gly Glu Ala Ile Ser Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Ala Ile Ala Gly Val Lys Gly Gly Ala Tyr Ser 
65                  70                  75                  80  


His Pro Leu His Ala Leu Phe Thr Thr 
                85                  


<210>  292
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk305 HlgC binding FN3 domain

<400>  292

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Lys Tyr Ala Glu His Val Val Trp Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Glu Val Gly Ile Ala Gly Val Lys Gly Gly Thr Val Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Arg Phe Thr Thr 
                85                  


<210>  293
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk306 HlgC, LukS binding FN3 domain

<400>  293

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Leu Tyr Asp Glu Ile Trp Pro Ser Gly Glu Ala Ile Ser Leu Gly 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Asn Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Asp Ala Lys Phe Thr Thr 
                85                  


<210>  294
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk307 HlgC, LukS binding FN3 domain

<400>  294

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Thr Glu Ser Arg Tyr Tyr Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Arg Ile Ser Gly Val Lys Gly Gly Ala Phe Ser 
65                  70                  75                  80  


Thr Pro Leu Trp Ala Ala Ala Thr Thr 
                85                  


<210>  295
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk308 HlgC binding FN3 domain

<400>  295

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Gly Glu Arg Leu Arg Phe Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Gly Ile Ser Gly Val Lys Gly Gly Trp Phe Ser 
65                  70                  75                  80  


Asn Pro Leu Arg Ala Ile Phe Thr Thr 
                85                  


<210>  296
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk309 HlgC binding FN3 domain

<400>  296

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Lys 
            20                  25                  30          


Ile Phe Tyr Leu Glu Ser Asp Trp Glu Gly Glu Ala Ile Ala Leu Trp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Phe Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Ile Pro Leu His Ala Asn Phe Thr Thr 
                85                  


<210>  297
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk310 HlgC, LukS binding FN3 domain

<400>  297

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Thr Glu Thr Ala Lys Trp Gly Glu Ala Ile Thr Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Gly Ile Gly Gly Val Lys Gly Gly Gly Trp Ser 
65                  70                  75                  80  


Trp Pro Leu Asp Ala Ile Phe Thr Thr 
                85                  


<210>  298
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk311 HlgC binding FN3 domain

<400>  298

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ser Tyr Val Glu Pro Asp Asp Gly Glu Ala Ile Glu Leu Leu Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Ile Val Gln Ile Asp Gly Val Lys Gly Gly Thr Thr Ser Val 
65                  70                  75                  80  


Pro Leu Asn Ala Arg Phe Thr Thr 
                85              


<210>  299
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk312 HlgC binding FN3 domain

<400>  299

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Ser Glu Tyr Pro Glu Tyr Gly Glu Ala Ile Asp Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Gly Ile Thr Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Asn Ala Thr Phe Thr Thr 
                85                  


<210>  300
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk313 HlgC, LukS binding FN3 domain

<400>  300

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Asn Glu Ile Gly Lys Trp Gly Glu Ala Ile Asp Leu Ile 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Gly Ile Asp Gly Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Pro Ala Ser Phe Thr Thr 
                85                  


<210>  301
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk314 HlgC binding FN3 domain

<400>  301

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Thr Glu Phe Asn Phe Lys Gly Glu Ala Ile Pro Leu Asp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ser Ile His Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Glu Ala Leu Phe Thr Thr 
                85                  


<210>  302
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk315 HlgC binding FN3 domain

<400>  302

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ser Tyr Gln Glu Pro Asp Glu Ile Gly Glu Ala Ile Glu Leu Ile 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gln Ile Asp Gly Val Lys Gly Gly Thr Trp Ser 
65                  70                  75                  80  


Ile Pro Leu Asn Ala Tyr Phe Thr Thr 
                85                  


<210>  303
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk317 HlgC, LukS binding FN3 domain

<400>  303

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr His Glu Phe Pro Thr Trp Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Arg Ile Ser Gly Val Lys Gly Gly Thr Thr Ser 
65                  70                  75                  80  


Gln Pro Leu Gln Ala Ala Ala Thr 
                85              


<210>  304
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk318 HlgC, LukS, HlgA binding FN3 domain

<400>  304

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr His Glu Thr Val Gly Phe Gly Glu Ala Ile Ala Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Ala Ile Asp Gly Val Lys Gly Gly Trp Phe Ser 
65                  70                  75                  80  


His Pro Leu Val Ala Tyr Phe Thr Thr 
                85                  


<210>  305
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk319 HlgC, LukS binding FN3 domain

<400>  305

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Phe Glu Arg Phe Asn Trp Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Gln Ile Asp Gly Val Lys Gly Gly Asp Ile Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Arg Phe Thr Thr 
                85                  


<210>  306
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk320 HlgC, LukS binding FN3 domain

<400>  306

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Ser Glu Trp Glu Gln Leu Gly Glu Ala Ile Asp Leu Ile 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Gly Ile Ala Gly Val Lys Gly Gly Ser Ser Ser 
65                  70                  75                  80  


Phe Pro Leu Gly Ala Glu Phe Thr Thr 
                85                  


<210>  307
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk321 HlgC binding FN3 domain

<400>  307

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Gln Glu Ala Ala Thr Trp Gly Glu Ala Ile Asp Leu Ser 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Gly Ile Val Gly Val Lys Gly Gly Gly Val Ser 
65                  70                  75                  80  


Thr Pro Leu Val Ala Pro Phe Thr Thr 
                85                  


<210>  308
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk322 HlgC, LukS binding FN3 domain

<400>  308

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Tyr Glu Ser His Arg Gly Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Gly Ile Thr Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Tyr Pro Leu His Ala Ile Phe Thr Thr 
                85                  


<210>  309
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk323 HlgC binding FN3 domain

<400>  309

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Glu Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr Pro Glu Pro Gly Phe Gln Gly Glu Ala Ile Ser Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Glu Val Gln Ile Ala Gly Val Lys Gly Gly His Val Ser 
65                  70                  75                  80  


Trp Pro Leu Val Ala Thr Phe Thr Thr 
                85                  


<210>  310
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk324 HlgC, LukS binding FN3 domain

<400>  310

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr Glu Glu Val Arg Ala Glu Gly Glu Ala Ile Glu Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Gly Ile Asp Gly Val Lys Gly Gly Gly Phe Ser 
65                  70                  75                  80  


Ser Pro Leu Val Ala His Phe Thr Thr 
                85                  


<210>  311
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk326 HlgC binding FN3 domain

<400>  311

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr Tyr Glu Arg Thr Gln Gln Gly Glu Ala Ile Glu Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Asp Gly Val Lys Gly Gly Glu Val Ser 
65                  70                  75                  80  


Gln Pro Leu Lys Ala His Phe Thr Thr 
                85                  


<210>  312
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk327 HlgC binding FN3 domain

<400>  312

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Leu Glu Trp Leu Tyr His Gly Glu Ala Ile Lys Leu Tyr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Val Ile His Gly Val Lys Gly Gly Phe Val Ser 
65                  70                  75                  80  


Thr Pro Leu Phe Ala Thr Phe Thr Thr 
                85                  


<210>  313
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk329 HlgC, LukF binding FN3 domain

<400>  313

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Trp Glu Gly Ile Gly Tyr Gly Glu Ala Ile Thr Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asn Val Gly Ile Asp Gly Val Lys Gly Gly Asp Phe Ser 
65                  70                  75                  80  


Thr Pro Leu Trp Ala Arg Phe Thr Thr 
                85                  


<210>  314
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk330 HlgC, LukS binding FN3 domain

<400>  314

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr His Glu Phe Ser Thr Tyr Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Lys Ile Ala Gly Val Lys Gly Gly Ala Thr Ser 
65                  70                  75                  80  


Val Pro Leu Val Ala Thr Phe Thr Thr 
                85                  


<210>  315
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk331 HlgC, LukS, LukD binding FN3 domain

<400>  315

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Phe Glu Asp Asp Glu Arg Gly Glu Ala Ile Val Leu Asn 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Ile Ile His Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Tyr Ala Thr Phe Thr Thr 
                85                  


<210>  316
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk332 HlgC, LukS, LukAB binding FN3 domain

<400>  316

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr Gly Glu Trp Glu Tyr Pro Gly Glu Ala Ile Glu Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Gly Ile Asp Gly Val Lys Gly Gly Arg Val Ser 
65                  70                  75                  80  


Tyr Pro Leu Arg Ala Gln Phe Thr Thr 
                85                  


<210>  317
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk333 HlgC binding FN3 domain

<400>  317

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile His Tyr Trp Glu Gly Leu Phe Val Gly Glu Ala Ile Val Leu Ser 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Pro Ile Tyr Gly Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Tyr Ala Leu Phe Thr Thr 
                85                  


<210>  318
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk334 HlgC binding FN3 domain

<400>  318

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Gly Tyr His Glu Ala Glu Gly Phe Gly Glu Ala Ile Ala Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val Gly Ile Ser Gly Val Lys Gly Gly Phe Val Ser 
65                  70                  75                  80  


Phe Pro Leu Trp Ala Arg Phe Thr Thr 
                85                  


<210>  319
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk335 HlgC, LukS binding FN3 domain

<400>  319

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Asn Glu Ile Val Asn His Gly Glu Ala Ile Asp Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Ser Ile Gly Gly Val Lys Gly Gly His Trp Ser 
65                  70                  75                  80  


Val Pro Leu Trp Ala Arg Phe Thr Thr 
                85                  


<210>  320
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk336 HlgC, LukS binding FN3 domain

<400>  320

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr His Glu Trp Ile Gly Pro Gly Glu Ala Ile Ser Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Ala Gly Val Lys Gly Gly Trp Ser Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Thr Phe Thr Thr 
                85                  


<210>  321
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk337 HlgC, LukS binding FN3 domain

<400>  321

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Glu Glu Pro Leu Tyr Phe Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val His Ile Gly Gly Val Lys Gly Gly Arg Val Ser 
65                  70                  75                  80  


Ile Pro Leu Glu Ala Glu Phe Thr Thr 
                85                  


<210>  322
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk338 HlgC, LukS binding FN3 domain

<400>  322

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr Glu Glu Asp Asn Ala Gln Gly Glu Ala Ile Glu Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Lys Ile Asp Gly Val Lys Gly Gly Arg Val Ser 
65                  70                  75                  80  


Thr Pro Leu Val Ala Arg Phe Thr Thr 
                85                  


<210>  323
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk339 HlgC binding FN3 domain

<400>  323

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Trp Glu Gly Gln Trp Asn Gly Glu Ala Ile Leu Leu Asp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Pro Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Val Ala Thr Phe Thr Thr 
                85                  


<210>  324
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk340 HlgC, LukS binding FN3 domain

<400>  324

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr His Glu Ser Pro Tyr Ala Gly Glu Ala Ile Asp Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Gly Ile Ala Gly Val Lys Gly Gly Gly Tyr Ser 
65                  70                  75                  80  


Ile Pro Leu Arg Ala Ile Phe Thr Thr 
                85                  


<210>  325
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk342 HlgC, LukS binding FN3 domain

<400>  325

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Ser Glu Pro Thr Ile Tyr Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Thr Gly Val Lys Gly Gly Trp Asn Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  326
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk343 HlgC binding FN3 domain

<400>  326

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Thr Glu Thr His Trp Phe Gly Glu Ala Ile Asn Leu Pro 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Trp Ala Ala Phe Thr Thr 
                85                  


<210>  327
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk344 HlgC, LukS binding FN3 domain

<400>  327

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ser Tyr Val Glu Pro Val Phe Ser Gly Glu Ala Ile Glu Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Gly Ile Gly Gly Val Lys Gly Gly Gly Trp Ser 
65                  70                  75                  80  


Ile Pro Leu Glu Ala His Phe Thr Thr 
                85                  


<210>  328
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk345 HlgC binding FN3 domain

<400>  328

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Phe Tyr Ile Glu Ala Lys Phe Arg Gly Glu Ala Ile Arg Leu Gly 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Trp Ile His Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Glu Ala Pro Phe Thr Thr 
                85                  


<210>  329
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk346 HlgC, LukS binding FN3 domain

<400>  329

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr Tyr Glu Ile Val Gly Trp Gly Glu Ala Ile Thr Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Lys Tyr Val Val Leu Ile Asp Gly Val Lys Gly Gly Leu Leu Ser 
65                  70                  75                  80  


Gln Pro Leu His Ala Glu Phe Ala Thr 
                85                  


<210>  330
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk347 HlgC, LukS binding FN3 domain

<400>  330

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr His Glu Thr Thr Arg Phe Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Ala Ile Gln Gly Val Lys Gly Gly His Val Ser 
65                  70                  75                  80  


Gln Pro Leu Arg Ala Pro Phe Thr Thr 
                85                  


<210>  331
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk348 HlgC binding FN3 domain

<400>  331

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Ile Tyr Leu Glu Ala Ser Phe Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ser Ile Tyr Gly Val Lys Gly Gly His Phe Ser 
65                  70                  75                  80  


Pro Pro Leu Asp Ala Ile Phe Thr Thr 
                85                  


<210>  332
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk349 HlgC binding FN3 domain

<400>  332

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Arg Glu Trp Ile Gln Trp Gly Glu Ala Ile Ser Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Gly Ile Thr Gly Val Asn Gly Gly Val Thr Ser 
65                  70                  75                  80  


Val Pro Leu His Ala Lys Phe Thr Thr 
                85                  


<210>  333
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk350 HlgC, LukF binding FN3 domain

<400>  333

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr His Glu Gly Leu Ser Trp Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Asp Gly Val Lys Gly Gly Tyr Thr Ser 
65                  70                  75                  80  


Glu Pro Leu Arg Ala Ser Phe Thr Thr 
                85                  


<210>  334
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk351 HlgC, LukS binding FN3 domain

<400>  334

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Asp Glu Thr Leu Thr Tyr Gly Glu Ala Ile Thr Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Gly Ile Asp Gly Val Lys Gly Gly Arg Asn Ser 
65                  70                  75                  80  


Val Pro Leu Lys Ala Thr Phe Thr Thr 
                85                  


<210>  335
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk353 HlgC, LukS binding FN3 domain

<400>  335

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr His Glu Pro Arg Ala Trp Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Gly Ile Gly Gly Val Lys Gly Gly Lys Gln Ser 
65                  70                  75                  80  


Lys Pro Leu Val Ala Lys Phe Thr Thr 
                85                  


<210>  336
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk354 HlgC, LukS binding FN3 domain

<400>  336

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Thr Glu Gln Lys Asn His Gly Glu Ala Ile Asp Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Glu Val Asn Ile Ala Gly Val Lys Gly Gly Gly Trp Ser 
65                  70                  75                  80  


Ile Pro Leu Asn Ala Trp Phe Thr Thr 
                85                  


<210>  337
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk355 HlgC binding FN3 domain

<400>  337

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Lys 
            20                  25                  30          


Ile Val Tyr Val Glu Ile His Tyr Arg Gly Glu Ala Ile His Leu Ser 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Val Ile His Gly Val Lys Gly Gly Gly Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Asp Ala Pro Phe Thr Thr 
                85                  


<210>  338
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk356 HlgC, LukS binding FN3 domain

<400>  338

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Thr Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Ser Glu Asp Gln Arg Thr Gly Glu Ala Ile Asp Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Ala Ile Ala Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Asn Phe Thr Thr 
                85                  


<210>  339
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk357 HlgC binding FN3 domain

<400>  339

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Phe Glu Ser Leu Leu Thr Gly Glu Ala Ile Ser Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Pro Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ile Ala Ile Phe Thr Thr 
                85                  


<210>  340
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk358 HlgC, LukS binding FN3 domain

<400>  340

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Asn Tyr Tyr Glu Tyr Tyr Pro Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  341
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk361 HlgC binding FN3 domain

<400>  341

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Tyr Tyr Tyr Glu Tyr Tyr Ala Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Val Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  342
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk362 HlgC binding FN3 domain

<400>  342

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Tyr Tyr Leu Glu Tyr Ser Phe Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Tyr Ile Tyr Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  343
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk363 HlgC binding FN3 domain

<400>  343

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Tyr Tyr Tyr Glu Trp Ala Ser Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly His Ile Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  344
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk364 HlgC binding FN3 domain

<400>  344

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr His Glu Tyr Ser Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Ser Val Lys Gly Gly Ser Val Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  345
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk365 HlgC, LukS binding FN3 domain

<400>  345

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Tyr Tyr Tyr Glu Tyr Trp Tyr Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  346
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk366 HlgC, LukS binding FN3 domain

<400>  346

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Phe Asn Trp Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  347
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk368 HlgC binding FN3 domain

<400>  347

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Tyr Tyr Phe Glu Ser Ile Asn Leu Gly Asp Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Tyr Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  348
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk369 HlgC binding FN3 domain

<400>  348

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Tyr Gly Gly Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  349
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk370 HlgC binding FN3 domain

<400>  349

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Tyr Tyr Phe Glu Tyr Trp Thr Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Tyr Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  350
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk371 HlgC binding FN3 domain

<400>  350

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Ile Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Tyr Asp Ser Gly Glu Ala Ile Val Leu Thr Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Thr Val Ala Ile Phe Gly Val Lys Gly Gly Tyr Ile Ser Ala 
65                  70                  75                  80  


Pro Leu Ser Ala Ile Phe Thr Thr 
                85              


<210>  351
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk372 HlgC, LukS binding FN3 domain

<400>  351

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gly Tyr Glu Glu Tyr Ala Asn Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Phe Ile Tyr Gly Val Lys Gly Gly Tyr Tyr Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  352
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk373 HlgC binding FN3 domain

<400>  352

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Tyr Tyr Phe Glu Tyr Ile Asn Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Tyr Ile His Gly Val Lys Gly Gly Phe Val Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  353
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk374 HlgC binding FN3 domain

<400>  353

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Glu Tyr Trp Glu Tyr Arg Leu Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Ala Val Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  354
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk375 HlgC binding FN3 domain

<400>  354

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Asp Tyr Trp Glu Tyr Val Phe Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ser Ile Thr Gly Val Lys Gly Gly Arg Tyr Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  355
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk376 HlgC, LukS binding FN3 domain

<400>  355

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Pro Tyr Tyr Glu Tyr Trp Trp Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  356
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk377 HlgC binding FN3 domain

<400>  356

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Asn Tyr Trp Glu Tyr Tyr Pro His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Ser Tyr Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  357
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk378 HlgC, LukS binding FN3 domain

<400>  357

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr His Glu Asp Ala Tyr Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Leu Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  358
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk379 HlgC binding FN3 domain

<400>  358

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Leu Tyr His Glu Tyr Glu Tyr Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Leu Tyr Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  359
<211>  85
<212>  PRT
<213>  Artificial

<220>
<223>  Luk380 HlgC, LukS binding FN3 domain

<400>  359

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Asn Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Val Tyr Gly Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
        35                  40                  45              


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Tyr 
    50                  55                  60                  


Val Pro Ile Ala Gly Val Lys Gly Gly Gly Val Ser Trp Pro Leu Ser 
65                  70                  75                  80  


Ala Ile Phe Thr Thr 
                85  


<210>  360
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk381 HlgC, LukS binding FN3 domain

<400>  360

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Tyr Tyr Tyr Glu Tyr Tyr Lys Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  361
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk382 HlgC binding FN3 domain

<400>  361

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Ile Tyr Asp Glu Thr Ala Gln Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Pro Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  362
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk390 LukD binding FN3 domain

<400>  362

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Tyr Ile His His Gly Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Trp Gly Tyr Trp Asn 
65                  70                  75                  80  


Pro Thr Gln Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  363
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk394 LukE binding FN3 domain

<400>  363

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Gln Tyr Arg Leu Asn Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asn Trp Gly Tyr Phe Leu 
65                  70                  75                  80  


Ala Pro Glu Ile Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  364
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk399 LukE binding FN3 domain

<400>  364

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Gly Gln Thr Arg Lys Phe Asn Ile Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Gly Ile 
65                  70                  75                  80  


Phe Leu Thr Phe Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  365
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk409 LukD binding FN3 domain

<400>  365

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Tyr Thr Leu Tyr Gln His Tyr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Ala Trp Trp 
65                  70                  75                  80  


Ser Phe Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  366
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk412 LukE binding FN3 domain

<400>  366

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Gly Tyr Leu Glu Tyr Pro Trp Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Asp Ile Tyr Gly Val Lys Gly Gly Trp Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  367
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk414 LukE binding FN3 domain

<400>  367

Leu Pro Ala Pro Asn Leu Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Asp Tyr Ile Glu Thr Tyr Tyr Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Trp Tyr Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  368
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk415 LukE binding FN3 domain

<400>  368

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile Ser Tyr Thr Glu Tyr Gly Ile Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Asp Ile Tyr Gly Val Lys Gly Gly Tyr Leu Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  369
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk417 LukE binding FN3 domain

<400>  369

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Asp Tyr Phe Glu Tyr Tyr Glu Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  370
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk420 LukAB binding FN3 domain

<400>  370

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Leu Gly Arg Phe Asn Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gln Trp Ile Ile Ser 
65                  70                  75                  80  


Glu Glu Ser Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  371
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk428 LukF binding FN3 domain

<400>  371

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Ile Lys Glu Glu Thr Ile Ile Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asn Ile Ile Glu 
65                  70                  75                  80  


Leu His Leu Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  372
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk438 HlgC binding FN3 domain

<400>  372

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Lys Pro Lys Arg Trp Arg His Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Pro Asp 
65                  70                  75                  80  


Thr Pro Thr Pro Val Ile Ile Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  373
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk445 HlgA binding FN3 domain

<400>  373

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Val Asn Thr Lys Thr Ser Asn Lys Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Tyr Trp 
65                  70                  75                  80  


Leu Thr Asn Val Val Leu Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  374
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk447 LukD binding FN3 domain

<400>  374

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Ile Asp Asp Tyr Phe Val His Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Ile His 
65                  70                  75                  80  


Phe Glu Phe Thr Thr Tyr Ser Arg Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  375
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk449 LukE, HlgA binding FN3 domain

<400>  375

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Ser Tyr Asp Glu Tyr Pro Glu Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Ile Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  376
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk452 LukE, HlgA binding FN3 domain

<400>  376

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile His Tyr Ala Glu Tyr Pro Asp Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Asp Ile Trp Gly Val Lys Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  377
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk460 LukF binding FN3 domain

<400>  377

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Trp Gly Gly Glu Ser Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Gln Ile Gly Phe Ile 
65                  70                  75                  80  


Tyr Arg Pro Glu Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  378
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk461 LukF binding FN3 domain

<400>  378

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Gly Pro Thr Ala Thr Val Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Ser Leu Leu His 
65                  70                  75                  80  


His Arg Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  379
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk462 LukF binding FN3 domain

<400>  379

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp His Pro Ile Trp Val Asp Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Gly Asp Gly Phe Glu 
65                  70                  75                  80  


Val Ile Leu His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  380
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk463 LukF binding FN3 domain

<400>  380

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Trp Phe Lys Thr Thr Ala Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu His Ala Ser Glu 
65                  70                  75                  80  


Ile His Gln Trp Glu Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  381
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk464 LukF binding FN3 domain

<400>  381

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Trp Pro Val Ala Pro Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Ala Ile Asn Tyr Val 
65                  70                  75                  80  


Tyr Phe Pro Thr Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  382
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk465 LukF binding FN3 domain

<400>  382

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Thr Asp Pro Gly Thr Asn Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Ser Trp Val His 
65                  70                  75                  80  


Ser Arg Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  383
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk467 LukF binding FN3 domain

<400>  383

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Trp Leu Gln Tyr Pro Phe Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Tyr Leu Asp Trp 
65                  70                  75                  80  


His Ile Phe Gln Leu Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  384
<211>  99
<212>  PRT
<213>  Artificial

<220>
<223>  Luk468 LukF binding FN3 domain

<400>  384

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gln Pro Ser His Gly Glu Phe Ala Asn Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Pro Trp 
65                  70                  75                  80  


Tyr Arg Gly Gly His Ile Tyr Asp Phe Ser Asn Pro Leu Ser Ala Ile 
                85                  90                  95      


Phe Thr Thr 
            


<210>  385
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk470 LukF binding FN3 domain

<400>  385

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Asn Tyr Ser Asp Pro Asp Phe Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Tyr His Trp Trp 
65                  70                  75                  80  


Tyr Arg Gly Thr Pro Val Val Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  386
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk473 LukF, LukD, LukAB binding FN3 domain

<400>  386

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Glu Gly Phe Phe Pro Gln Pro Leu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Leu Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Pro Trp Tyr 
65                  70                  75                  80  


His His Arg Trp Trp Phe Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  387
<211>  99
<212>  PRT
<213>  Artificial

<220>
<223>  Luk475 LukF binding FN3 domain

<400>  387

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Gln His Thr Asn Thr His Tyr Gln Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Val Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Trp Ile 
65                  70                  75                  80  


Asp Asn His Leu Lys Phe Asn Val His Ser Asn Pro Leu Ser Ala Ile 
                85                  90                  95      


Phe Thr Thr 
            


<210>  388
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk476 LukF, LukS, LukD, LukE, LukAB, HlgB, HlgC binding FN3 
       domain

<400>  388

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Glu Gly Phe Phe Pro Gln Pro Leu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Pro Trp Tyr 
65                  70                  75                  80  


His His Arg Trp Trp Phe Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  389
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk478 HlgC binding FN3 domain

<400>  389

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Glu Gly Phe Phe Pro Gln Pro Leu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Ser Arg 
65                  70                  75                  80  


Trp His Ser Phe Pro Val Thr Thr Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  390
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk479 LukF, LukD binding FN3 domain

<400>  390

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Glu Gly Phe Phe Pro Gln Pro Leu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Gly Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Pro Trp Tyr 
65                  70                  75                  80  


His His Arg Trp Trp Phe Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  391
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk483 LukF binding FN3 domain

<400>  391

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Arg Phe Thr Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val His Ile Trp Gly Val Lys Gly Gly Ile Asp Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  392
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk486 LukD, LukAB binding FN3 domain

<400>  392

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Arg Tyr Gly Glu Glu Thr Val His Gly Glu Ala Ile Ala Leu Ile 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val Ala Ile Ala Gly Val Lys Gly Gly Thr Trp Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  393
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk487 LukF binding FN3 domain

<400>  393

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile His Tyr Leu Glu Phe His Tyr Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Val Ile Tyr Gly Val Lys Gly Asp Leu Ile Ser 
65                  70                  75                  80  


Gly Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  394
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk498 LukD binding FN3 domain

<400>  394

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Pro Gly Pro Phe Arg Arg Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Asn His Glu Trp 
65                  70                  75                  80  


Tyr His Ala Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  395
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk499 LukS binding FN3 domain

<400>  395

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Gly Arg Glu Leu Ile Trp Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr His Glu Trp 
65                  70                  75                  80  


Arg Ser Glu Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  396
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk500 LukS binding FN3 domain

<400>  396

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Lys Pro Ser Tyr Tyr Ile Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Asn His Glu Trp 
65                  70                  75                  80  


Tyr His Ala Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  397
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk505 LukS binding FN3 domain

<400>  397

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gln Gln Ala Ala Arg Trp Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Arg Glu Trp Phe 
65                  70                  75                  80  


His Ser Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  398
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk507 LukS binding FN3 domain

<400>  398

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gln His His Gly Phe Arg Leu Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Phe Thr His Glu Trp 
65                  70                  75                  80  


Phe His Glu Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  399
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk510 LukS binding FN3 domain

<400>  399

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Glu Tyr Ser Val Thr Thr Trp Trp Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asn Glu Leu 
65                  70                  75                  80  


Tyr Arg Pro Trp Val Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  400
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk513 LukS binding FN3 domain

<400>  400

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Thr Gly Gly Trp Arg Arg Asn Pro Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Leu His 
65                  70                  75                  80  


Arg Thr Ile Ile Ala Gly Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  401
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk516 LukS binding FN3 domain

<400>  401

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Gly Ala Asn Ser Arg His Trp Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Val Ser Glu 
65                  70                  75                  80  


Trp Phe His Ser Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  402
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk517 LukS binding FN3 domain

<400>  402

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Asn His Leu Glu Gly Glu Ala Trp Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Thr His 
65                  70                  75                  80  


Glu Trp Trp His Lys Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  403
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk519 LukS binding FN3 domain

<400>  403

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Leu Glu His His Asn Tyr His Tyr Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Phe Leu 
65                  70                  75                  80  


Gln Pro Ala Ile His Pro Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  404
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk520 HlgC, LukS binding FN3 domain

<400>  404

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Tyr Trp Ser Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile His Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  405
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk521 HlgC, LukS binding FN3 domain

<400>  405

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Thr Tyr Glu Glu Ala Thr Leu Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Gly Ile Thr Gly Val Lys Gly Gly Leu Gly Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  406
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk522 HlgC, LukS binding FN3 domain

<400>  406

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Leu Glu Gln Arg Phe Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Ile Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  407
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk523 HlgC, LukS binding FN3 domain

<400>  407

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Pro Tyr Leu Glu Arg Gln Leu Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Thr Ile Gly Gly Val Lys Gly Gly Ala Pro Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  408
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk524 HlgC, LukS binding FN3 domain

<400>  408

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Phe 
            20                  25                  30          


Ile Phe Tyr Leu Glu Tyr Ala His Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Ile Ile His Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  409
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk525 HlgC, LukS binding FN3 domain

<400>  409

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Phe Tyr Trp Glu Ser Val Thr Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ile Ile His Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  410
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk526 HlgC, LukS binding FN3 domain

<400>  410

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Phe Tyr Asp Glu His His Gln Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Tyr Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  411
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk527 HlgC, LukS binding FN3 domain

<400>  411

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Trp Glu Pro Asn Glu Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Glu Ile Tyr Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  412
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk528 HlgC, LukS binding FN3 domain

<400>  412

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Asp Tyr Arg Glu Glu Thr Pro Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ile Ile Leu Gly Val Lys Gly Gly Gly Asp Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  413
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk529 LukS binding FN3 domain

<400>  413

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Tyr Tyr Gly Glu Trp Asn Pro Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ile Ile Ser Gly Val Lys Gly Gly Pro Gln Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  414
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk530 HlgC, LukD binding FN3 domain

<400>  414

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Phe Tyr His Glu Ile Glu Glu Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Val Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  415
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk531 HlgC, LukS binding FN3 domain

<400>  415

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Leu Tyr His Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  416
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk532 HlgC, LukS binding FN3 domain

<400>  416

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Leu Glu Leu Glu Ser Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asn Val Ile Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  417
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk533 HlgC, LukS binding FN3 domain

<400>  417

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Phe Tyr Val Glu Leu Arg Asn Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Val Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  418
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk534 HlgC, LukS binding FN3 domain

<400>  418

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Thr Glu Trp Asn Glu Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Gln Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  419
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk535 HlgC, LukS binding FN3 domain

<400>  419

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Leu Glu Pro Thr Thr Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Pro Val Ser 
65                  70                  75                  80  


Gly Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  420
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk536 HlgC, LukS binding FN3 domain

<400>  420

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr Ile Glu Thr Asp Gly Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  421
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk537 HlgC, LukS binding FN3 domain

<400>  421

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr His Glu His Lys Ile Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  422
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk538 HlgC, LukS binding FN3 domain

<400>  422

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Phe Tyr Leu Glu Arg Ala Asn Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  423
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk539 HlgC, LukS binding FN3 domain

<400>  423

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Leu Glu Thr Leu Tyr His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Ile Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  424
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk540 LukS binding FN3 domain

<400>  424

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Pro Glu Asp Thr Glu Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asn Val His Ile Thr Gly Val Lys Gly Gly Ser Lys Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  425
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk541 LukS, LukD binding FN3 domain

<400>  425

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Leu Tyr Thr Glu Thr Glu Gln Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ile Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Gly Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  426
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk542 LukS binding FN3 domain

<400>  426

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Pro Glu Phe Arg Gly Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Ile Ile His Gly Val Lys Gly Gly Gly Asp Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  427
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk543 HlgC, LukS binding FN3 domain

<400>  427

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Thr Glu Thr Phe His Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Asp Ile Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  428
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk544 HlgC, LukS binding FN3 domain

<400>  428

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Leu Glu Glu Phe Trp Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  429
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk545 HlgC, LukS binding FN3 domain

<400>  429

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Ala Tyr Ile Glu Glu Arg Trp Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Leu Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  430
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk546 LukS binding FN3 domain

<400>  430

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Tyr Tyr Gly Glu Trp Pro His Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Ser Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Leu Ile Ile Gly Val Lys Gly Gly Gln Leu Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  431
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk547 HlgC, LukS binding FN3 domain

<400>  431

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Leu Glu Ser Ser Gly Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Arg Ile Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  432
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk548 HlgC, LukS, LukD binding FN3 domain

<400>  432

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Tyr Tyr Gly Glu Trp His Pro Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Phe Ile Leu Gly Val Lys Gly Gly Gln Asn Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  433
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk549 HlgC, LukS binding FN3 domain

<400>  433

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Ala Glu Ser Gly Asn Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Phe Ile Trp Gly Val Lys Gly Gly His Glu Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  434
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk550 HlgC, LukS binding FN3 domain

<400>  434

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Ala Glu Thr Asp Thr Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  435
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk551 HlgC, LukS binding FN3 domain

<400>  435

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr Gln Glu Tyr Ser Asn His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  436
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk552 HlgC, LukS binding FN3 domain

<400>  436

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr Asp Glu Asn Leu Trp Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  437
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk553 HlgC, LukS binding FN3 domain

<400>  437

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Ala Glu His Glu Lys Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ala Ile His Gly Val Lys Gly Gly His Ile Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  438
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk554 HlgC, LukS binding FN3 domain

<400>  438

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Phe Tyr Leu Glu Thr Phe Arg Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Tyr Val Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  439
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk555 HlgC, LukS binding FN3 domain

<400>  439

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Phe Tyr Pro Glu Thr Asn Tyr Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  440
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk556 HlgC, LukS binding FN3 domain

<400>  440

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Ile Glu Glu Glu Thr Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Ile Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  441
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk557 HlgC, LukS binding FN3 domain

<400>  441

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Pro Glu Val Asn Phe Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  442
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk558 HlgC, LukS binding FN3 domain

<400>  442

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr His Glu Trp Trp Lys Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Val Ile His Gly Val Lys Gly Gly His Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  443
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk559 HlgC, LukS binding FN3 domain

<400>  443

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Pro Glu Thr Arg Pro Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile Tyr Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  444
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk560 HlgC, LukS binding FN3 domain

<400>  444

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Ile Glu His Val Gln Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Ile Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  445
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  Luk561 HlgC, LukS binding FN3 domain

<400>  445

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Tyr Pro Glu Leu Tyr Phe His Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Phe Ile 
65                  70                  75                  80  


Ser Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  446
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk562 LukS, LukAB binding FN3 domain

<400>  446

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Lys Glu Tyr Thr His Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ile Ile His Ser Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  447
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk563 HlgC, LukS binding FN3 domain

<400>  447

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr Pro Glu His Tyr Gln Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  448
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk564 HlgC, LukS binding FN3 domain

<400>  448

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Ile Glu Phe Arg Tyr Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  449
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk565 HlgC, LukS binding FN3 domain

<400>  449

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Leu Glu Thr Trp Gly Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Leu Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  450
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk566 HlgC, LukS binding FN3 domain

<400>  450

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Tyr Glu His Ala Asp Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  451
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk567 HlgC, LukS binding FN3 domain

<400>  451

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Gln Glu Asp Ser Asp His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  452
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk568 HlgC, LukS binding FN3 domain

<400>  452

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr Ile Glu Glu His Asp Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  453
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk569 HlgC, LukS binding FN3 domain

<400>  453

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Leu Tyr Pro Glu Thr Gln Thr Ile Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Ile Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  454
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk570 LukS, LukD, LukAB binding FN3 domain

<400>  454

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Tyr Tyr Gly Glu Trp Arg Glu His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Leu Ile Gln Gly Val Lys Gly Gly Gln Thr Ser 
65                  70                  75                  80  


Gly Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  455
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk571 HlgC, LukS binding FN3 domain

<400>  455

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Lys 
            20                  25                  30          


Ile Phe Tyr Leu Glu Pro Lys Glu Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile Thr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  456
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk572 LukS binding FN3 domain

<400>  456

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile His Tyr Asp Glu Trp Glu Asn Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ile Ile Ile Gly Val Lys Gly Gly Val Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  457
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk575 HlgC, LukS binding FN3 domain

<400>  457

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Phe Tyr Val Glu Ile Pro Gln Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Gly Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  458
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk576 HlgC, LukS binding FN3 domain

<400>  458

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Leu Tyr His Glu Tyr Trp Ala Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Leu Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  459
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk577 HlgC, LukS binding FN3 domain

<400>  459

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Cys Glu His Trp Thr Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  460
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk578 HlgC, LukS binding FN3 domain

<400>  460

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Gln Glu His Leu Gly Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Val Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  461
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk579 HlgC, LukS binding FN3 domain

<400>  461

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr Glu Glu Thr Ala Asn Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly His Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  462
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk580 HlgC, LukS, LukAB binding FN3 domain

<400>  462

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr Pro Glu Thr Gln Lys Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  463
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk581 HlgC, LukS binding FN3 domain

<400>  463

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Gly Glu Tyr Glu Asn Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile Val Gly Val Lys Gly Gly Phe Asp Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  464
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk582 HlgC, LukS binding FN3 domain

<400>  464

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Phe Tyr His Glu Thr Val Asp Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Val Ser Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  465
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk583 HlgC, LukS binding FN3 domain

<400>  465

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr Arg Glu Glu Ser Lys Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile His Gly Val Lys Gly Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  466
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk584 HlgC, LukS binding FN3 domain

<400>  466

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr Gln Glu Val Val Glu Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  467
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk585 HlgC, LukS binding FN3 domain

<400>  467

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Pro Glu Thr Trp Ile Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Ile Ile Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  468
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk587 HlgC, LukS binding FN3 domain

<400>  468

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Pro Tyr Gln Glu Tyr Leu Gly Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  469
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk588 HlgC, LukS binding FN3 domain

<400>  469

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Tyr Glu His Gln Val Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  470
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk589 HlgC, LukS binding FN3 domain

<400>  470

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr Ala Glu Glu Gln Arg Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  471
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk590 HlgC, LukS binding FN3 domain

<400>  471

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Phe Tyr Leu Glu Glu Arg Leu Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Val Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  472
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk592 HlgC, LukS binding FN3 domain

<400>  472

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Tyr Glu Ala Val His Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Asn Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  473
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk593 HlgC, LukS binding FN3 domain

<400>  473

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Val Glu Leu Val Trp Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  474
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk594 HlgC, LukS binding FN3 domain

<400>  474

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile His Tyr Gly Glu Tyr Glu Asn Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  475
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk595 HlgC, LukS binding FN3 domain

<400>  475

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Ile Tyr Phe Glu Thr Lys Ala Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Val Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  476
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk596 HlgC, LukS binding FN3 domain

<400>  476

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Asp Glu Glu Trp Ser Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Phe Ile Tyr Gly Val Lys Gly Gly Ala Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  477
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk597 HlgC, LukS binding FN3 domain

<400>  477

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile His Tyr Leu Glu Thr Asp Pro Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ser Ile Tyr Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  478
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk598 HlgC, LukS binding FN3 domain

<400>  478

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Asp Glu Asp Arg Pro Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Tyr Leu Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  479
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk599 HlgC, LukS binding FN3 domain

<400>  479

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Phe Tyr Arg Glu Glu Thr Pro His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Leu Ile Leu Gly Val Lys Gly Gly Gly Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  480
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk601 HlgC, LukS binding FN3 domain

<400>  480

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Ile Glu Asp Asn Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Val Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Ile Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  481
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk602 HlgC, LukS binding FN3 domain

<400>  481

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Gln Glu Leu Asn Arg Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ile Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  482
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk603 HlgC, LukS binding FN3 domain

<400>  482

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Leu Glu Phe Trp Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asn Val Ile Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  483
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk604 LukS binding FN3 domain

<400>  483

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr Gly Glu Trp Pro Gln Glu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Val Ile Leu Gly Val Lys Gly Gly Gln Ala Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  484
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk605 HlgC, LukS, LukD binding FN3 domain

<400>  484

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile His Tyr Leu Glu His Ala Ala Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  485
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk606 HlgC, LukS binding FN3 domain

<400>  485

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Leu Glu Ser Tyr Pro Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Leu Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  486
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk607 HlgC, LukS binding FN3 domain

<400>  486

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr His Glu Trp Val Pro Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  487
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk608 HlgC, LukS binding FN3 domain

<400>  487

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Phe Tyr Gly Glu Tyr Glu Asn Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Phe Ile Ile Gly Val Lys Gly Gly Pro Asp Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  488
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk609 HlgC, LukS binding FN3 domain

<400>  488

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Arg Tyr Trp Glu Gly Pro Gly Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Arg Ile Val Gly Val Lys Gly Gly Lys Arg Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  489
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk610 LukS binding FN3 domain

<400>  489

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Phe 
            20                  25                  30          


Ile Tyr Tyr Gly Glu Tyr Asp Pro Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile Gln Gly Val Lys Gly Gly Gln Ala Ser 
65                  70                  75                  80  


Gly Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  490
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk611 HlgC, LukS binding FN3 domain

<400>  490

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Ala Tyr Ala Glu Phe Trp Arg Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Asn Ile Ala Gly Val Lys Gly Gly Glu Trp Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  491
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk612 HlgC, LukS binding FN3 domain

<400>  491

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Gln Glu Glu Ser Lys Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Ala Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  492
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk613 HlgC, LukS binding FN3 domain

<400>  492

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Phe Tyr Ile Glu Thr Asp Lys Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  493
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk614 HlgC, HlgA, LukS binding FN3 domain

<400>  493

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Phe Tyr Thr Glu Pro Val Gly His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ala Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  494
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk615 HlgC, LukS binding FN3 domain

<400>  494

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr Ile Glu His Arg Leu Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Leu Ile His Gly Val Lys Gly Gly Phe Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  495
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk616 HlgC, LukS binding FN3 domain

<400>  495

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Phe Tyr His Glu Gly Leu Lys Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Thr Ile Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  496
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk617 HlgC, LukS binding FN3 domain

<400>  496

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr His Glu Thr Arg Val Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  497
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk618 HlgC, LukS binding FN3 domain

<400>  497

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Phe Tyr Gln Glu Ala Val Glu Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile His Gly Val Lys Gly Gly Trp Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  498
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk619 LukS binding FN3 domain

<400>  498

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Leu Tyr Val Glu Glu Phe Thr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Ile Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  499
<211>  87
<212>  PRT
<213>  Artificial

<220>
<223>  Luk620 HlgC, LukS binding FN3 domain

<400>  499

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Tyr Ile Glu Ala Leu Gly Phe Gly Glu Ala Ile Val Leu Thr Val Pro 
        35                  40                  45              


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
    50                  55                  60                  


Tyr Phe Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser Glu Pro 
65                  70                  75                  80  


Leu Ser Ala Ile Phe Thr Thr 
                85          


<210>  500
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk621 HlgC, LukS binding FN3 domain

<400>  500

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Phe Tyr Leu Glu His Trp Asn Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Pro Ile His Gly Val Lys Gly Gly Ser Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  501
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk622 HlgC, LukS binding FN3 domain

<400>  501

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Phe Tyr Val Glu Trp Glu Val Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Val Ile Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  502
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk623 LukS binding FN3 domain

<400>  502

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr Leu Glu Glu Ser Lys Asn Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Val Ile His Gly Val Lys Gly Gly Val Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  503
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk624 HlgC, LukS binding FN3 domain

<400>  503

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Asn Glu Asp His Lys Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  504
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk625 HlgC, LukS binding FN3 domain

<400>  504

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Pro Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Asp Tyr Gln Glu Trp His Glu Gly Glu Ala Ile His Leu Leu Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Ala Val Ile Ile Val Gly Val Lys Gly Gly Lys Gly Ser His 
65                  70                  75                  80  


Pro Leu Ser Ala Ile Phe Thr Thr 
                85              


<210>  505
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk626 HlgC, LukS binding FN3 domain

<400>  505

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Tyr Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Tyr Glu Thr Thr Ile Pro Gly Glu Ala Ile Asp Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Gly Ile Asp Gly Val Lys Gly Gly Arg Tyr Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  506
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk627 LukS binding FN3 domain

<400>  506

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Phe Tyr Lys Glu Glu Ala Ile Pro Gly Glu Ala Ile Ala Leu Ile 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile His Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  507
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk628 LukS binding FN3 domain

<400>  507

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Asp Tyr Thr Glu Leu His Asn Trp Gly Glu Ala Ile His Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Leu Ile Val Gly Val Lys Gly Gly Thr Gly Ser 
65                  70                  75                  80  


Ile Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  508
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk629 HlgC, LukS binding FN3 domain

<400>  508

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Thr Tyr Glu Glu Glu Trp Trp Thr Gly Glu Ala Ile Phe Leu Asp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Thr Ile Lys Gly Val Lys Gly Gly Pro Trp Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  509
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk630 LukS binding FN3 domain

<400>  509

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Trp Tyr His Glu Trp Gly Pro Val Gly Glu Ala Ile Leu Leu Tyr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val Ala Ile His Gly Val Lys Gly Gly Gly Thr Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  510
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk631 LukS binding FN3 domain

<400>  510

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr Glu Glu Leu Arg Tyr Lys Gly Glu Ala Ile Trp Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val His Ile Trp Gly Val Lys Gly Gly Tyr Phe Ser 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  511
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk632 LukS binding FN3 domain

<400>  511

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Asp Tyr Trp Glu Gln Trp Asn Thr Gly Glu Ala Ile His Leu Tyr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Tyr Ile Val Gly Val Lys Gly Gly Tyr Ala Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  512
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk633 HlgC, LukS binding FN3 domain

<400>  512

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Asp Glu Asn His Leu Tyr Gly Glu Ala Ile Asp Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Ala Gly Val Lys Gly Gly Leu Glu Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  513
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk634 LukS binding FN3 domain

<400>  513

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Glu Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Ser Tyr Trp Glu Phe Pro Leu Gly Gly Glu Ala Ile Gly Leu Trp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Ile Ile Ala Gly Val Lys Gly Gly Glu Phe Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  514
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk635 HlgC, LukS binding FN3 domain

<400>  514

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Glu Tyr His Glu Trp Phe Ala Lys Gly Glu Ala Ile Gly Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Ile Ile Val Gly Val Lys Gly Gly Ala Tyr Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  515
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk636 HlgC, LukS binding FN3 domain

<400>  515

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Asp Tyr Trp Glu Gly Glu Phe Asp Gly Glu Ala Ile His Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Phe Ile Val Gly Val Lys Gly Gly His Gly Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  516
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk637 HlgC, LukS binding FN3 domain

<400>  516

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Pro Tyr Tyr Glu Leu Asp Ser Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  517
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk638 LukS binding FN3 domain

<400>  517

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Gly Tyr Gly Glu Tyr Asp Pro Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Leu Ile Ser Gly Val Lys Gly Gly Tyr Tyr Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  518
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk639 HlgC, LukS binding FN3 domain

<400>  518

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Tyr Tyr Leu Glu Ser Val Ala Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Pro Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  519
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk640 HlgC, LukS binding FN3 domain

<400>  519

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Pro Tyr Trp Glu Ser Tyr Tyr Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Ala Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  520
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk641 LukS binding FN3 domain

<400>  520

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Tyr Tyr Gly Glu Tyr His Ser Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Leu Ile Asp Gly Val Lys Gly Gly Leu Tyr Ser 
65                  70                  75                  80  


Gly Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  521
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk642 LukS binding FN3 domain

<400>  521

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Val Tyr Ala Glu Tyr Tyr Trp Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Tyr Ile Ala Gly Val Lys Gly Gly Tyr Gly Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  522
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk643 HlgC, LukS binding FN3 domain

<400>  522

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Pro Tyr Tyr Glu Ser Asn Leu Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly His Ile Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  523
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk644 HlgC, LukS binding FN3 domain

<400>  523

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Leu Tyr Tyr Glu Leu Ile Asp Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  524
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk645 HlgC, LukS binding FN3 domain

<400>  524

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ser Tyr Gly Glu Tyr Trp Pro Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Leu Ile Arg Gly Val Lys Gly Gly Asp Tyr Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  525
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk646 LukD binding FN3 domain

<400>  525

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Phe Tyr Gly Glu Tyr Asp Gly Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Tyr Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  526
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk647 LukS binding FN3 domain

<400>  526

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Tyr Tyr Gly Glu Trp Asp Pro Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Leu Ile Val Gly Val Lys Gly Gly Ser Thr Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  527
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk648 LukS binding FN3 domain

<400>  527

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gly Tyr Glu Glu Tyr Tyr Leu Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Trp Ile Lys Gly Val Lys Gly Gly Tyr Val Gly 
65                  70                  75                  80  


Arg Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  528
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk649 LukS binding FN3 domain

<400>  528

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Ala Tyr Ser Glu Arg Val Arg Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Ser Gly Val Lys Gly Gly Pro Tyr Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  529
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk650 HlgC, LukS binding FN3 domain

<400>  529

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile His Tyr Tyr Glu Ser Tyr Thr Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Gly Ile Tyr Gly Val Lys Gly Gly Tyr Ile Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  530
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk651 HlgA, LukD, LukAB binding FN3 domain

<400>  530

Leu Pro Ala Pro Lys Asn Leu Val Leu Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Gln Ala Thr Tyr Tyr Gln Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Glu Val Ile Pro 
65                  70                  75                  80  


Lys Leu Arg Tyr Lys Val Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  531
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk652 HlgA binding FN3 domain

<400>  531

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser Glu Val Glu Asp Ile Pro Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu His Tyr Asn Arg 
65                  70                  75                  80  


Gly Gln His Pro Trp His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  532
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk653 HlgA binding FN3 domain

<400>  532

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Leu Glu Val Ala Phe Tyr Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu His Leu Asp Glu 
65                  70                  75                  80  


Val Trp Trp Thr Ala Asn Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  533
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk654 HlgA, LukD binding FN3 domain

<400>  533

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser His Phe Pro Asn Asp Trp Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Tyr Trp Gln Phe 
65                  70                  75                  80  


Asp Ile Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  534
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk655 HlgA binding FN3 domain

<400>  534

Leu Pro Ala Pro Lys Asn Leu Val Val Cys Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Thr Tyr Thr Ser Asp Ala Gly Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Glu His Ala 
65                  70                  75                  80  


His Ile Gln Tyr Trp His Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  535
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk656 HlgA binding FN3 domain

<400>  535

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Glu Gln Trp Ala Asn Tyr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Glu His Leu 
65                  70                  75                  80  


Tyr Lys Glu Leu Trp Ser Tyr Thr Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  536
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk657 LukF binding FN3 domain

<400>  536

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser Glu Leu Glu Ala Arg Thr His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Ser Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Gln Gln Leu 
65                  70                  75                  80  


Val Ala Trp Arg Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  537
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk658 LukD binding FN3 domain

<400>  537

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Ala Arg Leu Asp Leu Pro Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asp Ala Trp Ile 
65                  70                  75                  80  


Pro Thr Val Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  538
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk659 HlgA binding FN3 domain

<400>  538

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Asn Tyr Trp Val Leu Asn Tyr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Val Trp Pro 
65                  70                  75                  80  


Gln Asp His Glu Trp Ile Asp Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  539
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk660 HlgA binding FN3 domain

<400>  539

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Arg Glu Val Asp Phe Thr Thr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Ser Tyr Tyr 
65                  70                  75                  80  


Ile Leu His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  540
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk661 LukAB binding FN3 domain

<400>  540

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Thr Tyr Arg Glu Gln Ile Phe Ala Gly Glu Val Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val Cys Ile Tyr Gly Val Lys Gly Gly Pro Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  541
<211>  74
<212>  PRT
<213>  Artificial

<220>
<223>  Luk662 LukS binding FN3 domain

<400>  541

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Asn Tyr Arg Glu Val Ile Asn Glu Gly Glu Ala Ile Ile Leu His 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Arg Pro Glu Arg Ser Glu Thr Gly 
    50                  55                  60                  


Tyr Arg Ile His Arg His His Ser Trp Cys 
65                  70                  


<210>  542
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk663 LukD binding FN3 domain

<400>  542

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Val His Asn His Leu Ala Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Pro Tyr Val Tyr 
65                  70                  75                  80  


Ala Gln Tyr Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  543
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk664 HlgC binding FN3 domain

<400>  543

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Lys Ser Gly Ala Pro Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Gly Trp Asp Pro 
65                  70                  75                  80  


Gly Ser Asp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  544
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk665 HlgC binding FN3 domain

<400>  544

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp His Val Arg Gly His Asp Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Trp Leu Pro Thr 
65                  70                  75                  80  


Thr Asp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  545
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk666 HlgC binding FN3 domain

<400>  545

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser Pro Asp Arg Ala Arg Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Ser Trp Asp Asn Asp 
65                  70                  75                  80  


Asp Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  546
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk667 HlgC binding FN3 domain

<400>  546

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Phe Ala Gly Leu Gln Leu Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asp Trp Thr Val Glu Glu 
65                  70                  75                  80  


Gln Ser Tyr His Leu Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  547
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk668 HlgC binding FN3 domain

<400>  547

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ile Pro His Tyr Thr Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Pro Gly Lys Tyr Ile Glu 
65                  70                  75                  80  


Pro Arg Trp His Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  548
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk669 HlgC binding FN3 domain

<400>  548

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Tyr Ser Trp Leu Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Thr Trp Asp Pro Asn 
65                  70                  75                  80  


Asp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  549
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk670 HlgC binding FN3 domain

<400>  549

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Thr Ile Val Thr Thr Ile Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asp His Arg Gly Phe 
65                  70                  75                  80  


Pro Phe Trp Gln Tyr Trp Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  550
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk671 LukS binding FN3 domain

<400>  550

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Ala Arg Arg Ile Tyr Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Thr Pro Asn Pro Tyr 
65                  70                  75                  80  


Tyr Asp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  551
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk672 HlgC binding FN3 domain

<400>  551

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Leu Glu Gln Ser Thr Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Thr Thr Tyr Arg Ile Thr 
65                  70                  75                  80  


Val Pro Val Arg Asp His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  552
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk673 LukS binding FN3 domain

<400>  552

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Ala Ala Gly Thr Gly Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asn Trp Gln Pro Asp Tyr 
65                  70                  75                  80  


Trp Thr Trp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  553
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk674 HlgC binding FN3 domain

<400>  553

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Ile Ser His Leu Ser Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp His Gln Thr Val Gly 
65                  70                  75                  80  


Arg Trp Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  554
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk675 HlgC binding FN3 domain

<400>  554

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Arg Lys Lys Val Asn Arg Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Asn Trp Lys Pro 
65                  70                  75                  80  


Asn Asp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  555
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk676 HlgC binding FN3 domain

<400>  555

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Ser Ala Thr Gln His Pro Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asp Asn Trp Asp Pro 
65                  70                  75                  80  


Thr Asp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  556
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk677 HlgC binding FN3 domain

<400>  556

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Ile Ala Leu Arg Asp Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Ser Trp Asp Pro Thr 
65                  70                  75                  80  


Asp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  557
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk678 HlgC binding FN3 domain

<400>  557

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Asp Ala Glu Trp Phe Ala Pro His Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Leu Leu 
65                  70                  75                  80  


Lys Trp Pro Asn Tyr Ala Val Leu Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  558
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk679 HlgC binding FN3 domain

<400>  558

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Asn Asn Gln Arg Tyr Tyr Gln Pro Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Ser Trp 
65                  70                  75                  80  


Asn Pro His His Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  559
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk680 HlgC binding FN3 domain

<400>  559

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asp Ala Arg Val Thr Asp Glu Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asp Asp Leu 
65                  70                  75                  80  


Leu Thr Asn His Leu Leu Ala Ile Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  560
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk681 HlgC binding FN3 domain

<400>  560

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Lys Arg Asn Thr Leu Lys Ile Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Thr Trp Asp 
65                  70                  75                  80  


Pro Asn Asp Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  561
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk682 HlgC binding FN3 domain

<400>  561

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Asn Arg Val Lys Pro Asn Asp Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Thr Trp His 
65                  70                  75                  80  


Pro Gly His Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  562
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk683 LukD binding FN3 domain

<400>  562

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Thr Val Arg Phe Thr Lys Phe Glu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Ile Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Ser Ser 
65                  70                  75                  80  


Lys Pro Arg Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  563
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk684 HlgC binding FN3 domain

<400>  563

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Asn Tyr Arg Lys Val Val Ser Val Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Thr Trp 
65                  70                  75                  80  


His Pro Gly His Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  564
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk685 HlgC binding FN3 domain

<400>  564

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Asn Arg Gln Gln Val Arg Ser Ala Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Gly Trp 
65                  70                  75                  80  


His Pro Asn His Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  565
<211>  57
<212>  PRT
<213>  Artificial

<220>
<223>  Luk686 HlgC binding FN3 domain

<400>  565

Leu Pro Ala Arg Lys Thr Trp Leu Phe Leu Val Leu Pro Lys Thr Leu 
1               5                   10                  15      


Arg Val Cys Leu Gly Pro Arg Arg Thr Arg Arg Ser Thr Leu Phe Gly 
            20                  25                  30          


Leu Arg Thr Gln Arg Leu Leu Ser Gly Gly Lys Arg Leu Ala Cys Trp 
        35                  40                  45              


Cys Arg Val Leu Asn Val Leu Thr Thr 
    50                  55          


<210>  566
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  Luk687 HlgC, LukS binding FN3 domain

<400>  566

Leu Pro Ala Arg Lys Thr Trp Leu Phe Leu Val Leu Pro Lys Thr Leu 
1               5                   10                  15      


Arg Val Cys Leu Gly Pro Arg Arg Thr Arg Arg Ser Thr Leu Ser Gly 
            20                  25                  30          


Leu His Thr Gln Arg Arg His Pro Gly Val Lys Arg Ser Ala 
        35                  40                  45      


<210>  567
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk688 HlgC binding FN3 domain

<400>  567

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Glu Gly Gly Glu Tyr Tyr Tyr Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Pro Ile Gly Gly Val Lys Gly Gly Pro Asn Ser 
65                  70                  75                  80  


His Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  568
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk689 LukD, LukAB binding FN3 domain

<400>  568

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Phe Tyr Leu Thr Ser Trp Phe Ala Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Lys Val 
65                  70                  75                  80  


Asp Pro His Val Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  569
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk690 HlgB binding FN3 domain

<400>  569

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr His Val Asn Phe Gly Phe Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Tyr Glu Asp Tyr Pro 
65                  70                  75                  80  


Val Ile Ile Phe Asn Asn Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  570
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk691 LukF binding FN3 domain

<400>  570

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Asp Ile Lys Asn Lys Arg Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Gly Leu Ala Asn 
65                  70                  75                  80  


Pro Phe Arg Val Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  571
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk692 HlgB, LukD binding FN3 domain

<400>  571

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Tyr Gly Pro Trp Phe His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Thr His Val 
65                  70                  75                  80  


Arg Pro Pro Gln Trp Val Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  572
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk693 HlgB, LukD binding FN3 domain

<400>  572

Leu Pro Ala Pro Lys Ala Ala Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Tyr Gly Pro Trp Phe His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Thr His Val 
65                  70                  75                  80  


Arg Pro Pro Gln Trp Val Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  573
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk694 HlgB binding FN3 domain

<400>  573

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Asn Tyr Tyr Leu Glu Ser Arg His Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Gly Gln 
65                  70                  75                  80  


Phe Gly Trp Tyr Ile Glu Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  574
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk695 LukD, LukAB binding FN3 domain

<400>  574

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Asn Trp Glu Gln Tyr Ile Thr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Ile Ile Arg 
65                  70                  75                  80  


Asp Arg Ser His Trp Leu Asn Pro Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  575
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Luk696 HlgB binding FN3 domain

<400>  575

Leu Pro Ala Pro Lys Asn Leu Trp Leu Phe Leu Val Leu Pro Lys Thr 
1               5                   10                  15      


Leu Pro Val Cys Leu Gly Gly Val Met Ala Arg Gly Ser Thr Ser Thr 
            20                  25                  30          


Leu Ser 
        


<210>  576
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk697 HlgB binding FN3 domain

<400>  576

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Arg Phe Gly Pro Trp Phe His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Thr Gln Pro 
65                  70                  75                  80  


Glu Gln Glu Phe Lys Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  577
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk698 HlgB binding FN3 domain

<400>  577

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Tyr Gly Pro Trp Phe His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Thr His Val 
65                  70                  75                  80  


Arg Pro Pro Gln Trp Ile Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  578
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk699 HlgB binding FN3 domain

<400>  578

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Tyr Gly Pro Trp Phe His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gln His His 
65                  70                  75                  80  


Ser Leu Phe His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  579
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk700 LukD binding FN3 domain

<400>  579

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Gln Gln Leu Asn Tyr Gln Tyr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Tyr Arg Trp 
65                  70                  75                  80  


Trp Ser Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  580
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk701 HlgB binding FN3 domain

<400>  580

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Tyr Gly Pro Trp Phe His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Thr His Asn 
65                  70                  75                  80  


Asn Gln Pro Gly His Tyr Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  581
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk702 HlgB binding FN3 domain

<400>  581

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Tyr Gly Pro Trp Phe His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Thr His Val 
65                  70                  75                  80  


Arg Pro Pro Gln Trp Val Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  582
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk703 HlgB, LukD binding FN3 domain

<400>  582

Leu Pro Ala Pro Lys Ala Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Arg Tyr Gly Pro Trp Phe His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Thr His Val 
65                  70                  75                  80  


Arg Pro Pro Gln Trp Val Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  583
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk704 LukD binding FN3 domain

<400>  583

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Leu Tyr Gln Glu Arg Trp Trp Lys Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Pro Ile Thr Gly Val Lys Gly Gly Gly Val Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  584
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk705 LukAB binding FN3 domain

<400>  584

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Trp Tyr Arg Glu Ser Trp Tyr Phe Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Val Ile Arg Gly Val Lys Gly Gly Ser Leu Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  585
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk706 HlgB binding FN3 domain

<400>  585

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Ser Tyr Tyr Glu Gln Pro Arg Arg Gly Glu Ala Ile Trp Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Tyr Ile Thr Gly Val Lys Gly Gly Thr Trp Ser 
65                  70                  75                  80  


Phe Pro Leu Thr Ala Thr Phe Thr Thr 
                85                  


<210>  586
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk707 LukE binding FN3 domain

<400>  586

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Glu Tyr Tyr Glu Thr Lys Thr Lys Gly Glu Ala Ile Asn Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Ile Ile Leu Gly Val Lys Gly Gly Glu Pro Ser 
65                  70                  75                  80  


Ser Pro Leu Val Ala Pro Phe Thr Thr 
                85                  


<210>  587
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk708 LukAB binding FN3 domain

<400>  587

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Asp Val Gly Glu Trp Lys Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Gln Leu Thr Ile 
65                  70                  75                  80  


Thr Tyr Ser Pro Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  588
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk709 LukAB binding FN3 domain

<400>  588

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Ser Tyr His Pro Asn Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Asp Val Pro Thr 
65                  70                  75                  80  


Val Tyr His Pro Gly Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  589
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk710 LukAB binding FN3 domain

<400>  589

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Leu Lys Lys Val Ser Lys Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Glu Phe Pro Asp Arg 
65                  70                  75                  80  


Ile Tyr Trp Gly Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  590
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk711 LukAB binding FN3 domain

<400>  590

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Tyr Trp Val Gln Thr Ile Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Asn Leu Pro Asp 
65                  70                  75                  80  


Ile Phe Tyr Lys Leu Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  591
<211>  91
<212>  PRT
<213>  Artificial

<220>
<223>  Luk712 LukAB binding FN3 domain

<400>  591

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser Lys Lys Leu Glu Asn Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Tyr His Thr His Leu Ile 
65                  70                  75                  80  


Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90      


<210>  592
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk713 LukAB binding FN3 domain

<400>  592

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp His Asp Leu Thr Ile Trp Pro Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Ile Glu Phe Glu 
65                  70                  75                  80  


Ala Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  593
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk714 LukAB binding FN3 domain

<400>  593

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Phe Pro Trp Thr Glu Trp Ser Ala Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Asn Trp Leu 
65                  70                  75                  80  


Val Leu Ala Thr Ala Thr Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  594
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk715 LukAB binding FN3 domain

<400>  594

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Glu Trp Trp Ile Arg Pro Ile Glu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Gln Gln 
65                  70                  75                  80  


Leu Tyr Val Glu Ile Leu Ile Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  595
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk716 LukAB binding FN3 domain

<400>  595

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser Ser Gln Arg Thr Leu Pro Arg Glu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Val Ile 
65                  70                  75                  80  


Ile His Ser Gly Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  596
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk717 LukAB binding FN3 domain

<400>  596

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ser Arg Leu Glu Asp Phe Trp Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Ser Glu Val 
65                  70                  75                  80  


Tyr Phe Arg Tyr Tyr Glu His Trp Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  597
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk718 LukAB binding FN3 domain

<400>  597

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gln Val Asn Arg Asn Ala Gln Phe His Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala His Pro 
65                  70                  75                  80  


Lys Leu Val Trp Phe Ala Pro Pro Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  598
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk719 LukAB binding FN3 domain

<400>  598

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Phe Leu Glu Lys Trp Phe Ile Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Lys His His 
65                  70                  75                  80  


Asp His Asp Pro Glu Tyr Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  599
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk720 LukAB binding FN3 domain

<400>  599

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg His Pro Arg Ile Gln Gly Gly His Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile His Pro 
65                  70                  75                  80  


Phe Trp Trp Ser Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  600
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk721 LukAB binding FN3 domain

<400>  600

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Ala Lys Lys Ile Thr Pro Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Tyr Pro Glu 
65                  70                  75                  80  


Val Gln His Thr Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  601
<211>  91
<212>  PRT
<213>  Artificial

<220>
<223>  Luk722 LukAB binding FN3 domain

<400>  601

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Glu Pro Trp Gln Glu Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Leu Pro Thr Leu His 
65                  70                  75                  80  


Lys Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90      


<210>  602
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk723 LukAB binding FN3 domain

<400>  602

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Arg Phe Pro Arg Ile His Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Thr Asn Ile Asp 
65                  70                  75                  80  


Leu His Asn Tyr Asn Tyr Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  603
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk724 LukAB binding FN3 domain

<400>  603

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Glu Arg His Pro Trp Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Arg Gln Asn Ile Asn 
65                  70                  75                  80  


Ile Gln Asp Thr Asn Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  604
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk725 LukAB binding FN3 domain

<400>  604

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Trp Trp Glu Gly Trp Thr Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Ile Arg Thr Leu 
65                  70                  75                  80  


Lys Ala Ser Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  605
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk726 LukAB binding FN3 domain

<400>  605

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Ala Asn Phe Ile Asp Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Tyr Ser Pro Lys Leu Arg 
65                  70                  75                  80  


Trp Asp Leu Leu Asn Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  606
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk727 LukAB binding FN3 domain

<400>  606

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Phe Lys Gln Glu Phe Glu Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Tyr Tyr Pro Glu Tyr Tyr 
65                  70                  75                  80  


Pro Arg Glu Pro Trp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  607
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk728 LukAB binding FN3 domain

<400>  607

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Asp Glu Gly Thr Gln Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Trp Tyr Trp Tyr Trp 
65                  70                  75                  80  


Gln Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  608
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk729 LukAB binding FN3 domain

<400>  608

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Phe Gly Asn Gln Thr Gly Ala Arg Ser Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Tyr Tyr Gln 
65                  70                  75                  80  


Phe Arg Arg Thr Val Arg Asn Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  609
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk730 LukAB binding FN3 domain

<400>  609

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Glu Asn Arg Phe Val Leu Ser Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Tyr His Ala 
65                  70                  75                  80  


Arg His Thr Trp Trp Leu Gln Gln Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  610
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk731 LukAB binding FN3 domain

<400>  610

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Lys Gln Gln Leu Lys Lys Trp Ser Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Gly Tyr Thr Val Ser Ile Tyr Gly Val Glu His Ser 
65                  70                  75                  80  


Asn Thr Arg Lys Arg His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  611
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk732 LukAB binding FN3 domain

<400>  611

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Ile Asn Asp Asn Ser Gly Tyr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala His Arg Tyr 
65                  70                  75                  80  


Glu Asn Asn Pro Thr Leu Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  612
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk733 LukAB binding FN3 domain

<400>  612

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Ala Phe Arg Trp Gln Pro Pro Gly Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Gly Phe 
65                  70                  75                  80  


Leu Tyr Pro Trp Asn Tyr Pro Thr Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  613
<211>  99
<212>  PRT
<213>  Artificial

<220>
<223>  Luk734 LukAB binding FN3 domain

<400>  613

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Ser Glu Lys Pro Thr Thr Ser Leu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Pro Arg 
65                  70                  75                  80  


Ala Ile His Tyr Ala Tyr Trp Phe Asn Ser Asn Pro Leu Ser Ala Ile 
                85                  90                  95      


Phe Thr Thr 
            


<210>  614
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk735 LukAB binding FN3 domain

<400>  614

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gln Lys Ser Phe Gln Leu Thr Pro Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Val Glu Tyr 
65                  70                  75                  80  


Lys Trp Ala Ala Thr Asn Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  615
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk736 LukAB binding FN3 domain

<400>  615

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Ala Ser Leu Asn Ala Asn His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ser Glu 
65                  70                  75                  80  


Ser Asn Tyr Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  616
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk737 LukAB binding FN3 domain

<400>  616

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Asn Thr Ala Arg Leu Asn Lys Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Ile Thr His 
65                  70                  75                  80  


Ser His His His His Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  617
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk738 LukAB binding FN3 domain

<400>  617

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Leu Tyr Trp Glu Pro Thr Pro Ile Gly Glu Ala Ile Leu Leu Asn 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asn Val Glu Ile Asp Gly Val Lys Gly Gly Asn Pro Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  618
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk739 LukAB binding FN3 domain

<400>  618

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Ser Tyr Arg Glu Gly Gly Gln His Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Tyr Ile Leu Gly Val Lys Gly Gly Asp Glu Ser 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  619
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk740 LukAB binding FN3 domain

<400>  619

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Trp Trp Asn Lys His Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Trp Lys Lys Lys 
65                  70                  75                  80  


Pro Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  620
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk741 LukAB binding FN3 domain

<400>  620

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Trp Trp Asn Lys His Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Glu His Asp Trp Tyr 
65                  70                  75                  80  


Leu Leu Asn Tyr Ala Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  621
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk742 LukAB binding FN3 domain

<400>  621

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Ala Phe Ser Tyr Leu Gln Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Glu Val Arg Glu 
65                  70                  75                  80  


Asn Ser Trp Asn His Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  622
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk743 LukAB binding FN3 domain

<400>  622

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Glu Thr His Asn Pro Gln Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Trp Lys Lys 
65                  70                  75                  80  


Lys Pro Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  623
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk744 LukAB binding FN3 domain

<400>  623

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Thr Arg Val Asp Glu Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Trp Tyr Asn Trp Lys 
65                  70                  75                  80  


Lys Asn Val Asn Thr Glu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  624
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk745 LukAB binding FN3 domain

<400>  624

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser Gln Lys Asp Ile Asn Phe Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Trp Tyr Asn Trp 
65                  70                  75                  80  


Lys Lys Asn Trp Asp Asn Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  625
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk746 LukAB binding FN3 domain

<400>  625

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Phe Thr Thr Asn Asn His Trp Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Trp Lys Lys 
65                  70                  75                  80  


Lys Pro Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  626
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk747 LukAB binding FN3 domain

<400>  626

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Arg Ala Arg Glu Pro Ala Ser Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Thr Val Leu 
65                  70                  75                  80  


Phe Ile Asp Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  627
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk748 LukAB binding FN3 domain

<400>  627

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Val Arg Leu Ser Trp Tyr Asn Trp Lys Lys Lys Arg Leu Lys Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Pro Asn Leu 
65                  70                  75                  80  


Trp Asp Ile Trp Asn Trp Val Leu Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  628
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk749 LukAB binding FN3 domain

<400>  628

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Thr Phe Asn Leu Glu Val Tyr Ile Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Ser Ala 
65                  70                  75                  80  


Asn Trp His Gly His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  629
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk750 LukAB binding FN3 domain

<400>  629

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Gln Ile Phe Asn Glu Leu Trp Glu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Trp Tyr 
65                  70                  75                  80  


Asn Arg Lys Lys Lys Arg Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  630
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk751 LukAB binding FN3 domain

<400>  630

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Glu Gln Lys Lys Pro Ile Asn Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Trp Tyr 
65                  70                  75                  80  


Asn Arg Lys Lys Lys Arg Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  631
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk752 LukAB binding FN3 domain

<400>  631

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Gly Lys Tyr Ser Val Val Asp Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Pro Trp Tyr Asn 
65                  70                  75                  80  


Trp Lys Lys Lys Tyr Val Ile Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  632
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk753 LukAB binding FN3 domain

<400>  632

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Thr Lys Lys Asn Pro Val Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Leu Ile Lys 
65                  70                  75                  80  


Ser Leu Asn Ala Trp Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  633
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk754 LukAB binding FN3 domain

<400>  633

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val 
            20                  25                  30          


Ile Ile Tyr Glu Glu Val Gln Trp Arg Gly Glu Ala Ile Arg Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Asn Ile Arg Gly Val Lys Gly Gly Gly Ser Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  634
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk755 LukAB binding FN3 domain

<400>  634

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Trp Lys Lys Lys Pro Gly Tyr Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val His Tyr 
65                  70                  75                  80  


His Glu Trp Leu Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  635
<211>  99
<212>  PRT
<213>  Artificial

<220>
<223>  Luk756 LukAB binding FN3 domain

<400>  635

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Thr Val Lys Lys Lys Pro Gln Lys Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Asp Ala 
65                  70                  75                  80  


Tyr Pro Ile Ala Glu Trp Pro Ala Gln Ser Asn Pro Leu Ser Ala Ile 
                85                  90                  95      


Phe Thr Thr 
            


<210>  636
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk757 LukAB binding FN3 domain

<400>  636

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Thr Lys Lys Lys Pro Gln Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asn Glu Phe Ile 
65                  70                  75                  80  


Leu Arg Trp Glu Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  637
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk758 LukAB binding FN3 domain

<400>  637

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Gly Tyr Tyr Glu Leu Ile Gly Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Gly Ile Gln Gly Val Lys Gly Gly Ser Tyr Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  638
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk759 LukAB binding FN3 domain

<400>  638

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asp Arg Lys Val Glu Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Val Asp Gly Trp Gly 
65                  70                  75                  80  


Tyr Leu Leu Leu Val Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  639
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk760 LukAB binding FN3 domain

<400>  639

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Val Pro Arg Thr Phe His Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Ser Gln Tyr Ile 
65                  70                  75                  80  


Thr His Trp Leu Pro Lys Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  640
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  Luk761 LukAB binding FN3 domain

<400>  640

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Tyr Arg Val Ala Thr Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Val Glu Leu Leu Ser 
65                  70                  75                  80  


Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  641
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk762 LukAB binding FN3 domain

<400>  641

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gln Pro His Arg Tyr Glu Phe Tyr Gln Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Asp Phe 
65                  70                  75                  80  


Glu Phe Glu Leu His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  642
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk763 LukAB binding FN3 domain

<400>  642

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Pro Ser Tyr His Leu Phe Ala Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asn Asp Ala Glu 
65                  70                  75                  80  


Gln Arg Tyr His His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  643
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk764 LukAB binding FN3 domain

<400>  643

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Pro Ile Asn Lys Thr Thr Ser Pro Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Glu Ala His 
65                  70                  75                  80  


Tyr Asp Ala Phe Ile Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  644
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk765 LukAB binding FN3 domain

<400>  644

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Lys Lys Leu Trp Glu Ala Glu Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Leu Pro Asp 
65                  70                  75                  80  


Ser Phe His Val His His Cys Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  645
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk766 LukAB binding FN3 domain

<400>  645

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Pro Gln Trp Arg Arg Leu Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Val Asn Trp 
65                  70                  75                  80  


Pro Ala Ser Val Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  646
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk767 LukAB binding FN3 domain

<400>  646

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Trp Asp Ala Ile Gly Pro His Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Trp Phe 
65                  70                  75                  80  


Ile Arg Ile Thr Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  647
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk768 LukAB binding FN3 domain

<400>  647

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Gly Leu Glu Pro Arg Trp Gly Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Pro Trp Tyr Glu 
65                  70                  75                  80  


His Leu Arg Ile Leu Asn Ala Thr Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  648
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk769 LukAB binding FN3 domain

<400>  648

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Trp Trp Ser Asn Pro Ile Lys Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Asn Trp His 
65                  70                  75                  80  


Trp Tyr Gln Thr His Arg Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  649
<211>  99
<212>  PRT
<213>  Artificial

<220>
<223>  Luk770 LukAB binding FN3 domain

<400>  649

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Gln Trp His Ala Gly Val Asn Pro Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Tyr Tyr 
65                  70                  75                  80  


Val Arg Val Leu Gln Phe Ala Leu Phe Ser Asn Pro Leu Ser Ala Ile 
                85                  90                  95      


Phe Thr Thr 
            


<210>  650
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk771 LukAB binding FN3 domain

<400>  650

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Gln Val Glu Thr Gln Ile His Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ser Asp Leu 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser His Tyr Arg 
65                  70                  75                  80  


Arg His Val Pro Arg His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  651
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk772 LukAB binding FN3 domain

<400>  651

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ile Ala Tyr Tyr Tyr Gly Gln Thr Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp His Glu Asn 
65                  70                  75                  80  


Tyr Ala Lys Trp Pro Asp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  652
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk773 LukAB binding FN3 domain

<400>  652

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp His Trp Leu Thr His His Phe Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Phe Phe Arg Trp 
65                  70                  75                  80  


Gln Asp Pro Leu His Asp Leu Ile Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  653
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk774 LukAB binding FN3 domain

<400>  653

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Tyr Lys Glu His Phe Gln Ile Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Arg Ile Trp 
65                  70                  75                  80  


Trp Gln Tyr Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  654
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk775 LukAB binding FN3 domain

<400>  654

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Gly Asp Ala Tyr Phe Asn His Leu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Ala Arg 
65                  70                  75                  80  


Pro Lys Pro Arg Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  655
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk776 LukAB binding FN3 domain

<400>  655

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Lys Arg Val Pro Asn Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Trp Lys Lys Lys 
65                  70                  75                  80  


Pro Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  656
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk777 LukAB binding FN3 domain

<400>  656

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Glu Gln Lys Lys Arg Ser Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Pro Ile Arg 
65                  70                  75                  80  


Arg Ser Gly Trp Asp Val Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  657
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk778 LukAB binding FN3 domain

<400>  657

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Thr Lys Lys Lys Pro Val Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Val Asp Asp 
65                  70                  75                  80  


Trp Pro Asp Tyr Trp Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  658
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk779 LukAB binding FN3 domain

<400>  658

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Val Lys Lys Thr Phe Gln Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Ala Val Trp 
65                  70                  75                  80  


Tyr Thr Pro Asn Thr Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  659
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk780 LukAB binding FN3 domain

<400>  659

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Ser Lys Lys Lys Val Gln Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Glu Ser His 
65                  70                  75                  80  


Trp Trp Gln Leu Lys Trp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  660
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk781 LukAB binding FN3 domain

<400>  660

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Thr Lys Lys Lys Thr Ala Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Asp Glu Val 
65                  70                  75                  80  


Gly Tyr Leu His Ile Glu Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  661
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk782 LukAB binding FN3 domain

<400>  661

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Glu Lys Lys Ile Phe Gln Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Ala Lys Gly Pro Asn 
65                  70                  75                  80  


Phe Pro Ser Gln Asn Asp Pro Ser Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  662
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk783 LukAB binding FN3 domain

<400>  662

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Asn Trp Lys Lys Lys Arg Leu Lys Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Ser Pro 
65                  70                  75                  80  


Val Tyr Thr Gly Leu Tyr Leu Gly Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  663
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk784 LukAB binding FN3 domain

<400>  663

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Tyr Thr Val Lys Lys Lys Pro Gln Lys Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Asp Gln 
65                  70                  75                  80  


Leu Leu Glu Ile Gly Arg Thr Gly Ser Asn Pro Leu Ser Ala Ile Phe 
                85                  90                  95      


Thr Thr 
        


<210>  664
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk785 LukAB binding FN3 domain

<400>  664

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Phe 
            20                  25                  30          


Ile Gly Tyr Arg Glu Val Pro Phe Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Leu Ile Trp Gly Val Lys Gly Gly Ile Pro Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  665
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk786 LukAB binding FN3 domain

<400>  665

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Phe 
            20                  25                  30          


Ile Pro Tyr Arg Glu Glu Ala Pro Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Ile Ile Val Gly Val Lys Gly Gly Tyr Pro Ser 
65                  70                  75                  80  


Lys Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  666
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk787 LukAB binding FN3 domain

<400>  666

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Val Tyr His Glu Leu Val His Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val Phe Ile Val Gly Val Lys Gly Gly Trp Tyr Ser 
65                  70                  75                  80  


Pro Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  667
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  TCL24


<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (78)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<400>  667

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu Ala Ile Xaa Leu Xaa 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Pro Leu Xaa Ala Xaa Phe Thr Thr 
                85                  


<210>  668
<211>  872
<212>  PRT
<213>  S. aureus

<400>  668

Gly Ser Met Ala Ser Glu Asn Ser Val Thr Gln Ser Asp Ser Ala Ser 
1               5                   10                  15      


Asn Glu Ser Lys Ser Asn Asp Ser Ser Ser Val Ser Ala Ala Pro Lys 
            20                  25                  30          


Thr Asp Asp Thr Asn Val Ser Asp Thr Lys Thr Ser Ser Asn Thr Asn 
        35                  40                  45              


Asn Gly Glu Thr Ser Val Ala Gln Asn Pro Ala Gln Gln Glu Thr Thr 
    50                  55                  60                  


Gln Ser Ser Ser Thr Asn Ala Thr Thr Glu Glu Thr Pro Val Thr Gly 
65                  70                  75                  80  


Glu Ala Thr Thr Thr Thr Thr Asn Gln Ala Asn Thr Pro Ala Thr Thr 
                85                  90                  95      


Gln Ser Ser Asn Thr Asn Ala Glu Glu Leu Val Asn Gln Thr Ser Asn 
            100                 105                 110         


Glu Thr Thr Phe Asn Asp Thr Asn Thr Val Ser Ser Val Asn Ser Pro 
        115                 120                 125             


Gln Asn Ser Thr Asn Ala Glu Asn Val Ser Thr Thr Gln Asp Thr Ser 
    130                 135                 140                 


Thr Glu Ala Thr Pro Ser Asn Asn Glu Ser Ala Pro Gln Ser Thr Asp 
145                 150                 155                 160 


Ala Ser Asn Lys Asp Val Val Asn Gln Ala Val Asn Thr Ser Ala Pro 
                165                 170                 175     


Arg Met Arg Ala Phe Ser Leu Ala Ala Val Ala Ala Asp Ala Pro Ala 
            180                 185                 190         


Ala Gly Thr Asp Ile Thr Asn Gln Leu Thr Asn Val Thr Val Gly Ile 
        195                 200                 205             


Asp Ser Gly Thr Thr Val Tyr Pro His Gln Ala Gly Tyr Val Lys Leu 
    210                 215                 220                 


Asn Tyr Gly Phe Ser Val Pro Asn Ser Ala Val Lys Gly Asp Thr Phe 
225                 230                 235                 240 


Lys Ile Thr Val Pro Lys Glu Leu Asn Leu Asn Gly Val Thr Ser Thr 
                245                 250                 255     


Ala Lys Val Pro Pro Ile Met Ala Gly Asp Gln Val Leu Ala Asn Gly 
            260                 265                 270         


Val Ile Asp Ser Asp Gly Asn Val Ile Tyr Thr Phe Thr Asp Tyr Val 
        275                 280                 285             


Asn Thr Lys Asp Asp Val Lys Ala Thr Leu Thr Met Pro Ala Tyr Ile 
    290                 295                 300                 


Asp Pro Glu Asn Val Lys Lys Thr Gly Asn Val Thr Leu Ala Thr Gly 
305                 310                 315                 320 


Ile Gly Ser Thr Thr Ala Asn Lys Thr Val Leu Val Asp Tyr Glu Lys 
                325                 330                 335     


Tyr Gly Lys Phe Tyr Asn Leu Ser Ile Lys Gly Thr Ile Asp Gln Ile 
            340                 345                 350         


Asp Lys Thr Asn Asn Thr Tyr Arg Gln Thr Ile Tyr Val Asn Pro Ser 
        355                 360                 365             


Gly Asp Asn Val Ile Ala Pro Val Leu Thr Gly Asn Leu Lys Pro Asn 
    370                 375                 380                 


Thr Asp Ser Asn Ala Leu Ile Asp Gln Gln Asn Thr Ser Ile Lys Val 
385                 390                 395                 400 


Tyr Lys Val Asp Asn Ala Ala Asp Leu Ser Glu Ser Tyr Phe Val Asn 
                405                 410                 415     


Pro Glu Asn Phe Glu Asp Val Thr Asn Ser Val Asn Ile Thr Phe Pro 
            420                 425                 430         


Asn Pro Asn Gln Tyr Lys Val Glu Phe Asn Thr Pro Asp Asp Gln Ile 
        435                 440                 445             


Thr Thr Pro Tyr Ile Val Val Val Asn Gly His Ile Asp Pro Asn Ser 
    450                 455                 460                 


Lys Gly Asp Leu Ala Leu Arg Ser Thr Leu Tyr Gly Tyr Asn Ser Asn 
465                 470                 475                 480 


Ile Ile Trp Arg Ser Met Ser Trp Asp Asn Glu Val Ala Phe Asn Asn 
                485                 490                 495     


Gly Ser Gly Ser Gly Asp Gly Ile Asp Lys Pro Val Val Pro Glu Gln 
            500                 505                 510         


Pro Asp Glu Pro Gly Glu Ile Glu Pro Ile Pro Glu Asp Ser Asp Ser 
        515                 520                 525             


Asp Pro Gly Ser Asp Ser Gly Ser Asp Ser Asn Ser Asp Ser Gly Ser 
    530                 535                 540                 


Asp Ser Gly Ser Asp Ser Thr Ser Asp Ser Gly Ser Asp Ser Ala Ser 
545                 550                 555                 560 


Asp Ser Asp Ser Ala Ser Asp Ser Asp Ser Ala Ser Asp Ser Asp Ser 
                565                 570                 575     


Ala Ser Asp Ser Asp Ser Ala Ser Asp Ser Asp Ser Asp Asn Asp Ser 
            580                 585                 590         


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
        595                 600                 605             


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
    610                 615                 620                 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
625                 630                 635                 640 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
                645                 650                 655     


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
            660                 665                 670         


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
        675                 680                 685             


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
    690                 695                 700                 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
705                 710                 715                 720 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Ala Ser Asp Ser 
                725                 730                 735     


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
            740                 745                 750         


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
        755                 760                 765             


Asp Ser Asp Ser Glu Ser Asp Ser Asp Ser Glu Ser Asp Ser Asp Ser 
    770                 775                 780                 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
785                 790                 795                 800 


Asp Ser Ala Ser Asp Ser Asp Ser Gly Ser Asp Ser Asp Ser Ser Ser 
                805                 810                 815     


Asp Ser Asp Ser Glu Ser Asp Ser Asn Ser Asp Ser Glu Ser Gly Ser 
            820                 825                 830         


Asn Asn Asn Val Val Pro Pro Asn Ser Pro Lys Asn Gly Thr Asn Ala 
        835                 840                 845             


Ser Asn Lys Asn Glu Ala Lys Asp Ser Lys Glu Pro Leu Pro Asp Thr 
    850                 855                 860                 


Leu Glu His His His His His His 
865                 870         


<210>  669
<211>  845
<212>  PRT
<213>  S. aureus

<400>  669

Gly Ser Met Ala Ser Glu Gln Ser Asn Asp Thr Thr Gln Ser Ser Lys 
1               5                   10                  15      


Asn Asn Ala Ser Ala Asp Ser Glu Lys Asn Asn Met Ile Glu Thr Pro 
            20                  25                  30          


Gln Leu Asn Thr Thr Ala Asn Asp Thr Ser Asp Ile Ser Ala Asn Thr 
        35                  40                  45              


Asn Ser Ala Asn Val Asp Ser Thr Thr Lys Pro Met Ser Thr Gln Thr 
    50                  55                  60                  


Ser Asn Thr Thr Thr Thr Glu Pro Ala Ser Thr Asn Glu Thr Pro Gln 
65                  70                  75                  80  


Pro Thr Ala Ile Lys Asn Gln Ala Thr Ala Ala Lys Met Gln Asp Gln 
                85                  90                  95      


Thr Val Pro Gln Glu Ala Asn Ser Gln Val Asp Asn Lys Thr Thr Asn 
            100                 105                 110         


Asp Ala Asn Ser Ile Ala Thr Asn Ser Glu Leu Lys Asn Ser Gln Thr 
        115                 120                 125             


Leu Asp Leu Pro Gln Ser Ser Pro Gln Thr Ile Ser Asn Ala Gln Gly 
    130                 135                 140                 


Thr Ser Lys Pro Ser Val Arg Thr Arg Ala Val Arg Ser Leu Ala Val 
145                 150                 155                 160 


Ala Glu Pro Val Val Asn Ala Ala Asp Ala Lys Gly Thr Asn Val Asn 
                165                 170                 175     


Asp Lys Val Thr Ala Ser Asn Phe Lys Leu Glu Lys Thr Thr Phe Asp 
            180                 185                 190         


Pro Asn Gln Ser Gly Asn Thr Phe Met Ala Ala Asn Phe Thr Val Thr 
        195                 200                 205             


Asp Lys Val Lys Ser Gly Asp Tyr Phe Thr Ala Lys Leu Pro Asp Ser 
    210                 215                 220                 


Leu Thr Gly Asn Gly Asp Val Asp Tyr Ser Asn Ser Asn Asn Thr Met 
225                 230                 235                 240 


Pro Ile Ala Asp Ile Lys Ser Thr Asn Gly Asp Val Val Ala Lys Ala 
                245                 250                 255     


Thr Tyr Asp Ile Leu Thr Lys Thr Tyr Thr Phe Val Phe Thr Asp Tyr 
            260                 265                 270         


Val Asn Asn Lys Glu Asn Ile Asn Gly Gln Phe Ser Leu Pro Leu Phe 
        275                 280                 285             


Thr Asp Arg Ala Lys Ala Pro Lys Ser Gly Thr Tyr Asp Ala Asn Ile 
    290                 295                 300                 


Asn Ile Ala Asp Glu Met Phe Asn Asn Lys Ile Thr Tyr Asn Tyr Ser 
305                 310                 315                 320 


Ser Pro Ile Ala Gly Ile Asp Lys Pro Asn Gly Ala Asn Ile Ser Ser 
                325                 330                 335     


Gln Ile Ile Gly Val Asp Thr Ala Ser Gly Gln Asn Thr Tyr Lys Gln 
            340                 345                 350         


Thr Val Phe Val Asn Pro Lys Gln Arg Val Leu Gly Asn Thr Trp Val 
        355                 360                 365             


Tyr Ile Lys Gly Tyr Gln Asp Lys Ile Glu Glu Ser Ser Gly Lys Val 
    370                 375                 380                 


Ser Ala Thr Asp Thr Lys Leu Arg Ile Phe Glu Val Asn Asp Thr Ser 
385                 390                 395                 400 


Lys Leu Ser Asp Ser Tyr Tyr Ala Asp Pro Asn Asp Ser Asn Leu Lys 
                405                 410                 415     


Glu Val Thr Asp Gln Phe Lys Asn Arg Ile Tyr Tyr Glu His Pro Asn 
            420                 425                 430         


Val Ala Ser Ile Lys Phe Gly Asp Ile Thr Lys Thr Tyr Val Val Leu 
        435                 440                 445             


Val Glu Gly His Tyr Asp Asn Thr Gly Lys Asn Leu Lys Thr Gln Val 
    450                 455                 460                 


Ile Gln Glu Asn Val Asp Pro Val Thr Asn Arg Asp Tyr Ser Ile Phe 
465                 470                 475                 480 


Gly Trp Asn Asn Glu Asn Val Val Arg Tyr Gly Gly Gly Ser Ala Asp 
                485                 490                 495     


Gly Asp Ser Ala Val Asn Pro Lys Asp Pro Thr Pro Gly Pro Pro Val 
            500                 505                 510         


Asp Pro Glu Pro Ser Pro Asp Pro Glu Pro Glu Pro Thr Pro Asp Pro 
        515                 520                 525             


Glu Pro Ser Pro Asp Pro Glu Pro Glu Pro Ser Pro Asp Pro Asp Pro 
    530                 535                 540                 


Asp Ser Asp Ser Asp Ser Asp Ser Gly Ser Asp Ser Asp Ser Gly Ser 
545                 550                 555                 560 


Asp Ser Asp Ser Glu Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
                565                 570                 575     


Asp Ser Asp Ser Asp Ser Glu Ser Asp Ser Asp Ser Glu Ser Asp Ser 
            580                 585                 590         


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
        595                 600                 605             


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
    610                 615                 620                 


Glu Ser Asp Ser Asp Ser Glu Ser Asp Ser Glu Ser Asp Ser Asp Ser 
625                 630                 635                 640 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
                645                 650                 655     


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
            660                 665                 670         


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
        675                 680                 685             


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
    690                 695                 700                 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
705                 710                 715                 720 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
                725                 730                 735     


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
            740                 745                 750         


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
        755                 760                 765             


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
    770                 775                 780                 


Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser 
785                 790                 795                 800 


Arg Val Thr Pro Pro Asn Asn Glu Gln Lys Ala Pro Ser Asn Pro Lys 
                805                 810                 815     


Gly Glu Val Asn His Ser Asn Lys Val Ser Lys Gln His Lys Thr Asp 
            820                 825                 830         


Ala Leu Pro Glu Thr Leu Glu His His His His His His 
        835                 840                 845 


<210>  670
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  SD peptide

<400>  670

Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
1               5                   10                  15      


Ser Asp Ser Asp His His His His His His His His 
            20                  25              


<210>  671
<211>  332
<212>  PRT
<213>  S. aureus

<400>  671

Asn Ser Ala His His His His His His Gly Ser His Lys Asp Ser Gln 
1               5                   10                  15      


Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln Lys Asp Lys 
            20                  25                  30          


Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro Asp Asp Ile 
        35                  40                  45              


Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val Tyr Asp Glu 
    50                  55                  60                  


Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile Asp Asp Pro 
65                  70                  75                  80  


Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly Ser Ile His 
                85                  90                  95      


Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn Ser Asn Trp 
            100                 105                 110         


Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val Lys Arg Asn 
        115                 120                 125             


Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys Ile Ser Thr 
    130                 135                 140                 


Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly Lys Phe Asp 
145                 150                 155                 160 


Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr Ser Lys Thr 
                165                 170                 175     


Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser Gly Lys Asn 
            180                 185                 190         


Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys Tyr 
        195                 200                 205             


Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg Asn 
    210                 215                 220                 


Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser Lys 
225                 230                 235                 240 


Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe Leu 
                245                 250                 255     


Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu Val 
            260                 265                 270         


Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile His 
        275                 280                 285             


Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu Ile 
    290                 295                 300                 


Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val Asp 
305                 310                 315                 320 


Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Glu Gly 
                325                 330         


<210>  672
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32A

<400>  672

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  673
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17T34A

<400>  673

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ala Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  674
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17E36A

<400>  674

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Ala Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  675
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17K38A

<400>  675

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Ala Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  676
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17F39A

<400>  676

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Ala Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  677
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17Y40A

<400>  677

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Ala Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  678
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17R41A

<400>  678

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  679
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17K68A

<400>  679

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  680
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W70A

<400>  680

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Ala Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  681
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17V72A

<400>  681

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Ala Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  682
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17Q78A

<400>  682

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Ala Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  683
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17G79A

<400>  683

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Ala Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  684
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W81A

<400>  684

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  685
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17G42A

<400>  685

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Ala Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  686
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17V46A

<400>  686

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Ala Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  687
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17E66A

<400>  687

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Ala Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  688
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17G77A

<400>  688

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Ala Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  689
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17P82A

<400>  689

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Ala Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  690
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17S84A

<400>  690

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ala Ala Ile Phe Thr Thr 
                85                  


<210>  691
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17I86A

<400>  691

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ala Phe Thr Thr 
                85                  


<210>  692
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32S

<400>  692

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  693
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17T34S

<400>  693

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Ser Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  694
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17E36S

<400>  694

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Ser Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  695
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17K38S

<400>  695

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Ser Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  696
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17F39S

<400>  696

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Ser Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  697
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17Y40S

<400>  697

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Ser Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  698
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17R41S

<400>  698

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  699
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17K68S

<400>  699

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  700
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W70S

<400>  700

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Ser Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  701
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17V72S

<400>  701

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Ser Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  702
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17Q78S

<400>  702

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  703
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17G79S

<400>  703

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Ser Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  704
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W81S

<400>  704

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  705
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17G42S

<400>  705

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Ser Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  706
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17A44S

<400>  706

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ser Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  707
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17V46S

<400>  707

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Ser Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  708
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17E66S

<400>  708

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Ser Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  709
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17G77S

<400>  709

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Ser Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  710
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17P82S

<400>  710

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Ser Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  711
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17S84S

<400>  711

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  712
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17I86S

<400>  712

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ser Phe Thr Thr 
                85                  


<210>  713
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32L

<400>  713

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  714
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17T34Q

<400>  714

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Gln Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  715
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17E36Q

<400>  715

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Gln Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  716
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17F39E

<400>  716

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Glu Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  717
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17Y40K

<400>  717

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Lys Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  718
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17R41V

<400>  718

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  719
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17K68T

<400>  719

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  720
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17V72Y

<400>  720

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Tyr Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  721
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17Q78H

<400>  721

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly His Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  722
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17G79R

<400>  722

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Arg Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  723
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W81N

<400>  723

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  724
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17wtFG

<400>  724

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  725
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17S38FG

<400>  725

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  726
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32D

<400>  726

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  727
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32T

<400>  727

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  728
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32Q

<400>  728

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  729
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W81D

<400>  729

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  730
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W81L

<400>  730

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  731
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W81T

<400>  731

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  732
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W81Q

<400>  732

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  733
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32LW81S

<400>  733

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  734
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32TW81S

<400>  734

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  735
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32SW81S

<400>  735

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  736
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32DW81D

<400>  736

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  737
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32TW81T

<400>  737

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Thr 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  738
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17W32QW81Q

<400>  738

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln 
            20                  25                  30          


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
65                  70                  75                  80  


Gln Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  739
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26H32A

<400>  739

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  740
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26E34A

<400>  740

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Ala Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  741
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26A36S

<400>  741

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ser Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  742
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26P38A

<400>  742

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Ala Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  743
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39A

<400>  743

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Ala Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  744
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V40A

<400>  744

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Ala Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  745
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W41A

<400>  745

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  746
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68A

<400>  746

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  747
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26F70A

<400>  747

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Ala Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  748
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26G72A

<400>  748

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Ala Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  749
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26H78A

<400>  749

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly Ala Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  750
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26N79A

<400>  750

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Ala Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  751
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26T81A

<400>  751

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  752
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26G42A

<400>  752

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Ala Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  753
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V46A

<400>  753

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Ala Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  754
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26E66A

<400>  754

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Ala Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  755
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26G77A

<400>  755

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Ala His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  756
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26P82A

<400>  756

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Ala Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  757
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26S84A

<400>  757

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ala Ala Ile Phe Thr Thr 
                85                  


<210>  758
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26I86A

<400>  758

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ala Phe Thr Thr 
                85                  


<210>  759
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26H32S

<400>  759

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  760
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26E34S

<400>  760

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Ser Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  761
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26A36S

<400>  761

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ser Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  762
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26P38S

<400>  762

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Ser Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  763
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39S

<400>  763

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Ser Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  764
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V40S

<400>  764

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Ser Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  765
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W41S

<400>  765

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Ser Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  766
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68S

<400>  766

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  767
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26F70S

<400>  767

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Ser Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  768
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26G72S

<400>  768

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Ser Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  769
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26H78S

<400>  769

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly Ser Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  770
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26N79S

<400>  770

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Ser Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  771
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26T81S

<400>  771

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Ser Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  772
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26G42S

<400>  772

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Ser Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  773
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26A44S

<400>  773

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ser Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  774
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V46S

<400>  774

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Ser Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  775
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26E66S

<400>  775

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Ser Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  776
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26G77S

<400>  776

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Ser His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  777
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26P82S

<400>  777

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Ser Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  778
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26S84S

<400>  778

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  779
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26I86S

<400>  779

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ser Phe Thr Thr 
                85                  


<210>  780
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26H32L

<400>  780

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  781
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26E34Q

<400>  781

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Gln Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  782
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26A36Q

<400>  782

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Gln Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  783
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39E

<400>  783

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Glu Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  784
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V40K

<400>  784

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Lys Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  785
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W41V

<400>  785

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  786
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68T

<400>  786

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  787
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26G72Y

<400>  787

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Tyr Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  788
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26N79R

<400>  788

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  789
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26T81N

<400>  789

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  790
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26wtFG

<400>  790

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  791
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26S38FG

<400>  791

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  792
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68D

<400>  792

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  793
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68T

<400>  793

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  794
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68Q

<400>  794

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  795
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39Q

<400>  795

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Gln Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  796
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39T

<400>  796

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Thr Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  797
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26S84D

<400>  797

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Asp Ala Ile Phe Thr Thr 
                85                  


<210>  798
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26S84T

<400>  798

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Thr Ala Ile Phe Thr Thr 
                85                  


<210>  799
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26S84Q

<400>  799

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Gln Ala Ile Phe Thr Thr 
                85                  


<210>  800
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W41Q

<400>  800

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  801
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W41T

<400>  801

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  802
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68DS84D

<400>  802

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Asp Ala Ile Phe Thr Thr 
                85                  


<210>  803
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68DS84T

<400>  803

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Thr Ala Ile Phe Thr Thr 
                85                  


<210>  804
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68TS84D

<400>  804

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Asp Ala Ile Phe Thr Thr 
                85                  


<210>  805
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68TS84T

<400>  805

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Thr Ala Ile Phe Thr Thr 
                85                  


<210>  806
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68QS84Q

<400>  806

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Gln Ala Ile Phe Thr Thr 
                85                  


<210>  807
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68QS84D

<400>  807

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Asp Ala Ile Phe Thr Thr 
                85                  


<210>  808
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68QS84T

<400>  808

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gln Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Thr Ala Ile Phe Thr Thr 
                85                  


<210>  809
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68DS84Q

<400>  809

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Gln Ala Ile Phe Thr Thr 
                85                  


<210>  810
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26V68TS84Q

<400>  810

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Gln Ala Ile Phe Thr Thr 
                85                  


<210>  811
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39QW41Q

<400>  811

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Gln Val Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  812
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39QW41T

<400>  812

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Gln Val Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  813
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39TW41Q

<400>  813

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Thr Val Gln Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  814
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26W39TW41T

<400>  814

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Glu Tyr Ala Glu Pro Thr Val Thr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  815
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27P32A

<400>  815

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  816
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27V34A

<400>  816

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Ala Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  817
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27Q36A

<400>  817

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Ala Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  818
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27W38A

<400>  818

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Ala Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  819
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27Q39A

<400>  819

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Ala Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  820
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27F40A

<400>  820

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Ala Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  821
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27Y41A

<400>  821

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Ala Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  822
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27L68A

<400>  822

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  823
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27D70A

<400>  823

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Ala Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  824
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27Y72A

<400>  824

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Ala Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  825
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27S78A

<400>  825

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ala Trp Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  826
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27W79A

<400>  826

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Ala Ser 
65                  70                  75                  80  


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  827
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27Y81A

<400>  827

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  828
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38E75A

<400>  828

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  829
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38L76A

<400>  829

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Ala Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  830
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38I77A

<400>  830

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ala Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  831
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38Y78A

<400>  831

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Ala His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  832
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38H79A

<400>  832

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr Ala Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  833
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38G80A

<400>  833

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Ala 
65                  70                  75                  80  


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  834
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38W81A

<400>  834

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Ala Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  835
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38L82A

<400>  835

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Ala Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  836
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38D83A

<400>  836

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Ala Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  837
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38F84A

<400>  837

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Ala Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  838
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38V85A

<400>  838

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Ala Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  839
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38F86A

<400>  839

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly 
65                  70                  75                  80  


Trp Leu Asp Phe Val Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  840
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  840

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  841
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  841

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ala Asp Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Phe Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Gly Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  842
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  842

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Gly Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg His Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  843
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  843

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ile Ile 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  844
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  844

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Tyr Val Ser Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Arg Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  845
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  845

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Gly 
                85                  90                  95      


Ser Thr Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  846
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  846

Asp Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Met Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  847
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  847

Gln Ser Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Ser Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


His Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Thr 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ile Leu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Arg Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  848
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  848

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  849
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  849

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys 
    530                 535                 540                 


Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555             


<210>  850
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  850

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  851
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  851

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys 
    530                 535                 540                 


Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555             


<210>  852
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  852

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly 
                645                 650                 655     


Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  853
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  853

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly 
                645                 650                 655     


His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  854
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  854

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly 
                645                 650                 655     


Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  855
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  855

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly 
                645                 650                 655     


Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  856
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  856

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  857
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  857

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys 
    530                 535                 540                 


Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
                645                 650                 655     


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  858
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  858

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  859
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  859

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys 
    530                 535                 540                 


Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
                645                 650                 655     


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  860
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  860

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly 
    530                 535                 540                 


His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555     


<210>  861
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  861

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
465                 470                 475                 480 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
                485                 490                 495     


Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val 
            500                 505                 510         


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
        515                 520                 525             


Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His 
    530                 535                 540                 


Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555 


<210>  862
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  862

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly 
    530                 535                 540                 


Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555     


<210>  863
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  863

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
465                 470                 475                 480 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
                485                 490                 495     


Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val 
            500                 505                 510         


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
        515                 520                 525             


Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser 
    530                 535                 540                 


Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555 


<210>  864
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  864

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
    530                 535                 540                 


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
            580                 585                 590         


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
        595                 600                 605             


His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu 
    610                 615                 620                 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn 
                645                 650                 655     


Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665     


<210>  865
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  865

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
    530                 535                 540                 


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
            580                 585                 590         


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
        595                 600                 605             


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
    610                 615                 620                 


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
                645                 650                 655     


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665 


<210>  866
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  866

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
    530                 535                 540                 


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
            580                 585                 590         


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
        595                 600                 605             


Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu 
    610                 615                 620                 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp 
                645                 650                 655     


Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665     


<210>  867
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  867

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
    530                 535                 540                 


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
            580                 585                 590         


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
        595                 600                 605             


Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr 
    610                 615                 620                 


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser 
                645                 650                 655     


Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665 


<210>  868
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  868

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly 
    530                 535                 540                 


His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
            580                 585                 590         


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
        595                 600                 605             


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
    610                 615                 620                 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
                645                 650                 655     


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665     


<210>  869
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  869

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
465                 470                 475                 480 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
                485                 490                 495     


Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val 
            500                 505                 510         


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
        515                 520                 525             


Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His 
    530                 535                 540                 


Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
                565                 570                 575     


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
            580                 585                 590         


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
        595                 600                 605             


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
    610                 615                 620                 


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
                645                 650                 655     


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665 


<210>  870
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  870

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly 
    530                 535                 540                 


Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
            580                 585                 590         


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
        595                 600                 605             


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
    610                 615                 620                 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
                645                 650                 655     


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665     


<210>  871
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  871

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
465                 470                 475                 480 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
                485                 490                 495     


Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val 
            500                 505                 510         


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
        515                 520                 525             


Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser 
    530                 535                 540                 


Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
                565                 570                 575     


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
            580                 585                 590         


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
        595                 600                 605             


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
    610                 615                 620                 


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
                645                 650                 655     


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665 


<210>  872
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  872

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
    530                 535                 540                 


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


<210>  873
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  873

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  874
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  874

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly 
    530                 535                 540                 


Val Lys Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


<210>  875
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  875

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  876
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  876

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
    530                 535                 540                 


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys 
                645                 650                 655     


Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  877
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  877

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
    530                 535                 540                 


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly 
                645                 650                 655     


Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  878
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  878

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
    530                 535                 540                 


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys 
                645                 650                 655     


Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  879
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  879

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
    530                 535                 540                 


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly 
                645                 650                 655     


Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  880
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  880

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
    530                 535                 540                 


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
                645                 650                 655     


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  881
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  881

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  882
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  882

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly 
    530                 535                 540                 


Val Lys Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
                645                 650                 655     


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  883
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  883

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  884
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  884

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  885
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  885

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  886
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  886

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys 
    530                 535                 540                 


Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555             


<210>  887
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  887

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  888
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  888

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys 
    530                 535                 540                 


Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
                645                 650                 655     


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  889
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  889

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly 
    530                 535                 540                 


His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
            580                 585                 590         


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
        595                 600                 605             


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
    610                 615                 620                 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
                645                 650                 655     


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665     


<210>  890
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  890

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
465                 470                 475                 480 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
                485                 490                 495     


Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val 
            500                 505                 510         


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
        515                 520                 525             


Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His 
    530                 535                 540                 


Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
                565                 570                 575     


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
            580                 585                 590         


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
        595                 600                 605             


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
    610                 615                 620                 


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
                645                 650                 655     


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665 


<210>  891
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  891

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
    530                 535                 540                 


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
                645                 650                 655     


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  892
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  892

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  893
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  893

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys 
    530                 535                 540                 


Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
                645                 650                 655     


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  894
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  894

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys 
    530                 535                 540                 


Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
                645                 650                 655     


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  895
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  895

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  896
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  896

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys 
    530                 535                 540                 


Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
            580                 585                 590         


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
        595                 600                 605             


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
    610                 615                 620                 


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
625                 630                 635                 640 


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His 
                645                 650                 655     


Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665         


<210>  897
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  897

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly 
                645                 650                 655     


Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  898
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  898

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
    530                 535                 540                 


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555     


<210>  899
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  899

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
    530                 535                 540                 


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


<210>  900
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  900

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Glu Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu 
545                 550                 555                 560 


Ser Ala Ile Phe Thr Thr 
                565     


<210>  901
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  901

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile 
    530                 535                 540                 


Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile 
545                 550                 555                 560 


Phe Thr Thr 
            


<210>  902
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  902

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly 
    530                 535                 540                 


Val Glu Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro 
545                 550                 555                 560 


Leu Ser Ala Ile Phe Thr Thr 
                565         


<210>  903
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  903

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu 
    530                 535                 540                 


Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser 
545                 550                 555                 560 


Ala Ile Phe Thr Thr 
                565 


<210>  904
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  904

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
465                 470                 475                 480 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
                485                 490                 495     


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
            500                 505                 510         


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
        515                 520                 525             


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr 
    530                 535                 540                 


His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe 
545                 550                 555                 560 


Thr Thr 
        


<210>  905
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  905

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Glu Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu 
545                 550                 555                 560 


Ser Ala Ile Phe Thr Thr 
                565     


<210>  906
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  906

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu 
                645                 650                 655     


Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala 
            660                 665                 670         


Ile Phe Thr Thr 
        675     


<210>  907
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  907

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile 
                645                 650                 655     


Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile 
            660                 665                 670         


Phe Thr Thr 
        675 


<210>  908
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  908

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
    530                 535                 540                 


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
            580                 585                 590         


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
        595                 600                 605             


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
    610                 615                 620                 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His 
                645                 650                 655     


Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr 
            660                 665                 670         


Thr 
    


<210>  909
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  909

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
    530                 535                 540                 


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
            580                 585                 590         


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
        595                 600                 605             


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
    610                 615                 620                 


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
625                 630                 635                 640 


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly 
                645                 650                 655     


Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670         


<210>  910
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  910

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
    530                 535                 540                 


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu 
                645                 650                 655     


Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser 
            660                 665                 670         


Ala Ile Phe Thr Thr 
        675         


<210>  911
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  911

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
    530                 535                 540                 


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu 
                645                 650                 655     


Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala 
            660                 665                 670         


Ile Phe Thr Thr 
        675     


<210>  912
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  912

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Glu Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu 
545                 550                 555                 560 


Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
            580                 585                 590         


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
        595                 600                 605             


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu 
    610                 615                 620                 


Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
625                 630                 635                 640 


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val 
                645                 650                 655     


Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala 
            660                 665                 670         


Ile Phe Thr Thr 
        675     


<210>  913
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  913

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu 
    530                 535                 540                 


Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser 
545                 550                 555                 560 


Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn 
            580                 585                 590         


Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr 
        595                 600                 605             


Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys 
    610                 615                 620                 


Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg 
625                 630                 635                 640 


Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp 
                645                 650                 655     


Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile 
            660                 665                 670         


Phe Thr Thr 
        675 


<210>  914
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  914

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile 
    530                 535                 540                 


Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile 
545                 550                 555                 560 


Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val 
            580                 585                 590         


Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro 
        595                 600                 605             


Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr 
    610                 615                 620                 


Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr 
625                 630                 635                 640 


Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val 
                645                 650                 655     


Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr 
            660                 665                 670         


Thr 
    


<210>  915
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  915

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
465                 470                 475                 480 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
                485                 490                 495     


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
            500                 505                 510         


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
        515                 520                 525             


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr 
    530                 535                 540                 


His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe 
545                 550                 555                 560 


Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
            580                 585                 590         


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
        595                 600                 605             


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
    610                 615                 620                 


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
625                 630                 635                 640 


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
                645                 650                 655     


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670         


<210>  916
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  916

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly 
    530                 535                 540                 


Val Glu Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro 
545                 550                 555                 560 


Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
            580                 585                 590         


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
        595                 600                 605             


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu 
    610                 615                 620                 


Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
625                 630                 635                 640 


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys 
                645                 650                 655     


Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser 
            660                 665                 670         


Ala Ile Phe Thr Thr 
        675         


<210>  917
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  917

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Glu Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser Asn Pro Leu 
545                 550                 555                 560 


Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
            580                 585                 590         


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
        595                 600                 605             


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu 
    610                 615                 620                 


Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
625                 630                 635                 640 


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val 
                645                 650                 655     


Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala 
            660                 665                 670         


Ile Phe Thr Thr 
        675     


<210>  918
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  918

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Asp Tyr Lys 
            660                 665                 670         


Asp Asp Asp Asp Lys 
        675         


<210>  919
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  919

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Glu 
1               5                   10                  15      


Thr Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser 
    50                  55                  60                  


Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
                85                  90                  95      


Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala 
            100                 105                 110         


Thr Ser Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
465                 470                 475                 480 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                485                 490                 495     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            500                 505                 510         


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        515                 520                 525             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    530                 535                 540                 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
545                 550                 555                 560 


Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro 
            580                 585                 590         


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
        595                 600                 605             


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr 
    610                 615                 620                 


Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro 
625                 630                 635                 640 


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
                645                 650                 655     


Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro 
            660                 665                 670         


Leu Ser Ala Ile Phe Thr Thr 
        675                 


<210>  920
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  920

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Glu 
1               5                   10                  15      


Thr Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser 
    50                  55                  60                  


Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
                85                  90                  95      


Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala 
            100                 105                 110         


Thr Ser Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
465                 470                 475                 480 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                485                 490                 495     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            500                 505                 510         


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        515                 520                 525             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    530                 535                 540                 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
545                 550                 555                 560 


Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro 
            580                 585                 590         


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
        595                 600                 605             


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr 
    610                 615                 620                 


Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro 
625                 630                 635                 640 


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
                645                 650                 655     


Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro 
            660                 665                 670         


Leu Ser Ala Ile Phe Thr Thr Asp Tyr Lys Asp Asp Asp Asp Lys 
        675                 680                 685         


<210>  921
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  921

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Arg Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Phe Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Asn Val Phe Phe Ser Gly Ser Ala Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Val Thr Ile Ser Ile Asp Thr Ser Glu Asn Gln Ser 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Pro Gln Ala Tyr Ser His Asp Ser Ser Gly His Ser Pro 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
465                 470                 475                 480 


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
                485                 490                 495     


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala 
            500                 505                 510         


Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
        515                 520                 525             


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val 
    530                 535                 540                 


Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser 
545                 550                 555                 560 


Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn 
            580                 585                 590         


Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr 
        595                 600                 605             


Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys 
    610                 615                 620                 


Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg 
625                 630                 635                 640 


Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp 
                645                 650                 655     


Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile 
            660                 665                 670         


Phe Thr Thr 
        675 


<210>  922
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  922

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Arg Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Phe Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Asn Val Phe Phe Ser Gly Ser Ala Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Val Thr Ile Ser Ile Asp Thr Ser Glu Asn Gln Ser 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Pro Gln Ala Tyr Ser His Asp Ser Ser Gly His Ser Pro 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
465                 470                 475                 480 


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
                485                 490                 495     


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala 
            500                 505                 510         


Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
        515                 520                 525             


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val 
    530                 535                 540                 


Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser 
545                 550                 555                 560 


Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn 
            580                 585                 590         


Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr 
        595                 600                 605             


Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys 
    610                 615                 620                 


Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg 
625                 630                 635                 640 


Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp 
                645                 650                 655     


Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile 
            660                 665                 670         


Phe Thr Thr 
        675 


<210>  923
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  923

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Ala Asn Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly 
    530                 535                 540                 


His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
            580                 585                 590         


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
        595                 600                 605             


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
    610                 615                 620                 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
                645                 650                 655     


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665     


<210>  924
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  924

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Ala Asn Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
465                 470                 475                 480 


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
                485                 490                 495     


Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile 
            500                 505                 510         


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
        515                 520                 525             


Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly 
    530                 535                 540                 


His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly 
545                 550                 555                 560 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                565                 570                 575     


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
            580                 585                 590         


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
        595                 600                 605             


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
    610                 615                 620                 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
625                 630                 635                 640 


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
                645                 650                 655     


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665     


<210>  925
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  925

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Arg Gly Ala Ser Gly Ile Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
465                 470                 475                 480 


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                485                 490                 495     


Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp 
            500                 505                 510         


Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        515                 520                 525             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile 
    530                 535                 540                 


Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe 
545                 550                 555                 560 


Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
            580                 585                 590         


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
        595                 600                 605             


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
    610                 615                 620                 


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
625                 630                 635                 640 


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
                645                 650                 655     


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670         


<210>  926
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  926

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Arg Gly Ala Ser Gly Ile Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
465                 470                 475                 480 


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                485                 490                 495     


Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp 
            500                 505                 510         


Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        515                 520                 525             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile 
    530                 535                 540                 


Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe 
545                 550                 555                 560 


Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
            580                 585                 590         


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
        595                 600                 605             


Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg 
    610                 615                 620                 


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
625                 630                 635                 640 


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly 
                645                 650                 655     


Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670         


<210>  927
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  927

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  928
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  928

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  929
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  929

Glu Val Gln Leu Val Glu Thr Gly Gly Val Ala Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Ala Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Trp Pro His Gly Val Asn Arg Phe Tyr Ala Asp Ser Met 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Asn Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gln Asp Tyr Val Pro Arg Lys Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
    530                 535                 540                 


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
                645                 650                 655     


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  930
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  930

Glu Val Gln Leu Val Glu Thr Gly Gly Val Ala Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Ala Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Trp Pro His Gly Val Asn Arg Phe Tyr Ala Asp Ser Met 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Asn Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gln Asp Tyr Val Pro Arg Lys Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
    530                 535                 540                 


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
                645                 650                 655     


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  931
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  931

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
    450                 455                 460                 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
465                 470                 475                 480 


Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val 
                485                 490                 495     


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
            500                 505                 510         


Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His 
        515                 520                 525             


Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Met Leu Pro Ala Pro 
    530                 535                 540                 


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
545                 550                 555                 560 


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu 
                565                 570                 575     


Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
            580                 585                 590         


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys 
        595                 600                 605             


Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser 
    610                 615                 620                 


Ala Ile Phe Thr Thr 
625                 


<210>  932
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  932

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
    450                 455                 460                 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
465                 470                 475                 480 


Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val 
                485                 490                 495     


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
            500                 505                 510         


Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His 
        515                 520                 525             


Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser 
    530                 535                 540                 


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
545                 550                 555                 560 


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
                565                 570                 575     


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
            580                 585                 590         


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
        595                 600                 605             


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
    610                 615                 620                 


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
625                 630                 


<210>  933
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  933

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
    450                 455                 460                 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
465                 470                 475                 480 


Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val 
                485                 490                 495     


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
            500                 505                 510         


Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His 
        515                 520                 525             


Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
545                 550                 555                 560 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                565                 570                 575     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            580                 585                 590         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        595                 600                 605             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    610                 615                 620                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
625                 630                 635                 


<210>  934
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  934

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
    450                 455                 460                 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
465                 470                 475                 480 


Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val 
                485                 490                 495     


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
            500                 505                 510         


Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His 
        515                 520                 525             


Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
545                 550                 555                 560 


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
                565                 570                 575     


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu 
            580                 585                 590         


Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        595                 600                 605             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val 
    610                 615                 620                 


Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala 
625                 630                 635                 640 


Ile Phe Thr Thr 
                


<210>  935
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  935

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
    450                 455                 460                 


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
465                 470                 475                 480 


Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val 
                485                 490                 495     


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
            500                 505                 510         


Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His 
        515                 520                 525             


Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
545                 550                 555                 560 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                565                 570                 575     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            580                 585                 590         


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        595                 600                 605             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    610                 615                 620                 


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
625                 630                 635                 640 


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 


<210>  936
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  936

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
    450                 455                 460                 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
465                 470                 475                 480 


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
                485                 490                 495     


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
            500                 505                 510         


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
        515                 520                 525             


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
    530                 535                 540                 


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
545                 550                 555                 560 


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
                565                 570                 575     


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
            580                 585                 590         


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
        595                 600                 605             


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
    610                 615                 620                 


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
625                 630                 


<210>  937
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  937

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
    450                 455                 460                 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
465                 470                 475                 480 


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
                485                 490                 495     


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
            500                 505                 510         


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
        515                 520                 525             


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
    530                 535                 540                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
545                 550                 555                 560 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                565                 570                 575     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            580                 585                 590         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        595                 600                 605             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    610                 615                 620                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
625                 630                 635                 


<210>  938
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  938

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
    450                 455                 460                 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
465                 470                 475                 480 


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
                485                 490                 495     


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
            500                 505                 510         


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
        515                 520                 525             


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
545                 550                 555                 560 


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
                565                 570                 575     


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu 
            580                 585                 590         


Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        595                 600                 605             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val 
    610                 615                 620                 


Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala 
625                 630                 635                 640 


Ile Phe Thr Thr 
                


<210>  939
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  939

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
    450                 455                 460                 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
465                 470                 475                 480 


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
                485                 490                 495     


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
            500                 505                 510         


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
        515                 520                 525             


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
545                 550                 555                 560 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                565                 570                 575     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            580                 585                 590         


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        595                 600                 605             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    610                 615                 620                 


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
625                 630                 635                 640 


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 


<210>  940
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  940

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
    450                 455                 460                 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
465                 470                 475                 480 


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
                485                 490                 495     


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
            500                 505                 510         


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
        515                 520                 525             


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
    530                 535                 540                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
                565                 570                 575     


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
            580                 585                 590         


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
        595                 600                 605             


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
    610                 615                 620                 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
625                 630                 635                 640 


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 650                 


<210>  941
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  941

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
    450                 455                 460                 


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
465                 470                 475                 480 


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala 
                485                 490                 495     


Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
            500                 505                 510         


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val 
        515                 520                 525             


Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser 
    530                 535                 540                 


Ala Ile Phe Thr Thr Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
545                 550                 555                 560 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                565                 570                 575     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            580                 585                 590         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        595                 600                 605             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    610                 615                 620                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
625                 630                 635                 


<210>  942
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  942

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
    450                 455                 460                 


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
465                 470                 475                 480 


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala 
                485                 490                 495     


Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
            500                 505                 510         


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val 
        515                 520                 525             


Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser 
    530                 535                 540                 


Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
545                 550                 555                 560 


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
                565                 570                 575     


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu 
            580                 585                 590         


Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        595                 600                 605             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val 
    610                 615                 620                 


Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala 
625                 630                 635                 640 


Ile Phe Thr Thr 
                


<210>  943
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  943

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
    450                 455                 460                 


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
465                 470                 475                 480 


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala 
                485                 490                 495     


Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
            500                 505                 510         


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val 
        515                 520                 525             


Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser 
    530                 535                 540                 


Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
545                 550                 555                 560 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                565                 570                 575     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            580                 585                 590         


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        595                 600                 605             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    610                 615                 620                 


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
625                 630                 635                 640 


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 


<210>  944
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  944

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
    450                 455                 460                 


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
465                 470                 475                 480 


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala 
                485                 490                 495     


Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
            500                 505                 510         


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val 
        515                 520                 525             


Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser 
    530                 535                 540                 


Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
                565                 570                 575     


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
            580                 585                 590         


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
        595                 600                 605             


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
    610                 615                 620                 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
625                 630                 635                 640 


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 650                 


<210>  945
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  945

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
    450                 455                 460                 


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
465                 470                 475                 480 


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala 
                485                 490                 495     


Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
            500                 505                 510         


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val 
        515                 520                 525             


Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser 
    530                 535                 540                 


Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn 
                565                 570                 575     


Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr 
            580                 585                 590         


Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys 
        595                 600                 605             


Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg 
    610                 615                 620                 


Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp 
625                 630                 635                 640 


Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile 
                645                 650                 655     


Phe Thr Thr 
            


<210>  946
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  946

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
465                 470                 475                 480 


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
                485                 490                 495     


His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu 
            500                 505                 510         


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
        515                 520                 525             


Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn 
    530                 535                 540                 


Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Met Leu Pro Ala Pro Lys 
545                 550                 555                 560 


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
                565                 570                 575     


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu 
            580                 585                 590         


Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        595                 600                 605             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val 
    610                 615                 620                 


Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala 
625                 630                 635                 640 


Ile Phe Thr Thr 
                


<210>  947
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  947

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
465                 470                 475                 480 


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
                485                 490                 495     


His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu 
            500                 505                 510         


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
        515                 520                 525             


Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn 
    530                 535                 540                 


Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Met 
545                 550                 555                 560 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                565                 570                 575     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            580                 585                 590         


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        595                 600                 605             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    610                 615                 620                 


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
625                 630                 635                 640 


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 


<210>  948
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  948

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
465                 470                 475                 480 


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
                485                 490                 495     


His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu 
            500                 505                 510         


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
        515                 520                 525             


Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn 
    530                 535                 540                 


Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
                565                 570                 575     


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
            580                 585                 590         


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
        595                 600                 605             


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
    610                 615                 620                 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
625                 630                 635                 640 


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 650                 


<210>  949
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  949

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
465                 470                 475                 480 


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
                485                 490                 495     


His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu 
            500                 505                 510         


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
        515                 520                 525             


Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn 
    530                 535                 540                 


Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn 
                565                 570                 575     


Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr 
            580                 585                 590         


Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys 
        595                 600                 605             


Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg 
    610                 615                 620                 


Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp 
625                 630                 635                 640 


Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile 
                645                 650                 655     


Phe Thr Thr 
            


<210>  950
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  950

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
465                 470                 475                 480 


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
                485                 490                 495     


His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu 
            500                 505                 510         


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
        515                 520                 525             


Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn 
    530                 535                 540                 


Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
                565                 570                 575     


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
            580                 585                 590         


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
        595                 600                 605             


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
    610                 615                 620                 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
625                 630                 635                 640 


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
                645                 650                 655     


Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 


<210>  951
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  951

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Met 
545                 550                 555                 560 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                565                 570                 575     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            580                 585                 590         


Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr 
        595                 600                 605             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    610                 615                 620                 


Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser 
625                 630                 635                 640 


Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 


<210>  952
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  952

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
                565                 570                 575     


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
            580                 585                 590         


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
        595                 600                 605             


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
    610                 615                 620                 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
625                 630                 635                 640 


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 650                 


<210>  953
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  953

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn 
                565                 570                 575     


Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr 
            580                 585                 590         


Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys 
        595                 600                 605             


Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg 
    610                 615                 620                 


Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp 
625                 630                 635                 640 


Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile 
                645                 650                 655     


Phe Thr Thr 
            


<210>  954
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  954

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
                565                 570                 575     


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
            580                 585                 590         


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
        595                 600                 605             


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
    610                 615                 620                 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
625                 630                 635                 640 


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
                645                 650                 655     


Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 


<210>  955
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  955

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys 
    530                 535                 540                 


Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
                645                 650                 655     


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  956
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  956

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys 
    530                 535                 540                 


Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly 
                645                 650                 655     


Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  957
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  957

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys 
    530                 535                 540                 


Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
545                 550                 555                 560 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu 
            580                 585                 590         


Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser 
        595                 600                 605             


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
    610                 615                 620                 


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
625                 630                 635                 640 


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His 
                645                 650                 655     


Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665         


<210>  958
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  958

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly 
                645                 650                 655     


Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  959
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  959

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr 
            580                 585                 590         


Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp 
        595                 600                 605             


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
    610                 615                 620                 


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
625                 630                 635                 640 


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly 
                645                 650                 655     


His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665             


<210>  960
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  960

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly 
    530                 535                 540                 


Val Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys 
                645                 650                 655     


Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  961
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  961

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
    530                 535                 540                 


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
                645                 650                 655     


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  962
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  962

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val 
465                 470                 475                 480 


Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp 
                485                 490                 495     


Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp 
            500                 505                 510         


Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp 
        515                 520                 525             


Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly 
    530                 535                 540                 


Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
            580                 585                 590         


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
        595                 600                 605             


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
    610                 615                 620                 


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
625                 630                 635                 640 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
                645                 650                 655     


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 670 


<210>  963
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  963

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
                565                 570                 575     


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
            580                 585                 590         


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
        595                 600                 605             


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
    610                 615                 620                 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
625                 630                 635                 640 


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
                645                 650                 


<210>  964
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  964

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Glu 
1               5                   10                  15      


Thr Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser 
    50                  55                  60                  


Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
                85                  90                  95      


Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala 
            100                 105                 110         


Thr Ser Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
465                 470                 475                 480 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                485                 490                 495     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            500                 505                 510         


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        515                 520                 525             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    530                 535                 540                 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
545                 550                 555                 560 


Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Met Leu 
                565                 570                 575     


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
            580                 585                 590         


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
        595                 600                 605             


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
    610                 615                 620                 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
625                 630                 635                 640 


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
                645                 650                 655     


Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 


<210>  965
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  965

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
                565                 570                 575     


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
            580                 585                 590         


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
        595                 600                 605             


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
    610                 615                 620                 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
625                 630                 635                 640 


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Asp Tyr 
                645                 650                 655     


Lys Asp Asp Asp Asp Lys 
            660         


<210>  966
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  966

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Glu 
1               5                   10                  15      


Thr Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser 
    50                  55                  60                  


Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
                85                  90                  95      


Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala 
            100                 105                 110         


Thr Ser Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
465                 470                 475                 480 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                485                 490                 495     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            500                 505                 510         


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        515                 520                 525             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    530                 535                 540                 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
545                 550                 555                 560 


Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Met Leu 
                565                 570                 575     


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
            580                 585                 590         


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
        595                 600                 605             


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
    610                 615                 620                 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
625                 630                 635                 640 


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
                645                 650                 655     


Pro Leu Ser Ala Ile Phe Thr Thr Asp Tyr Lys Asp Asp Asp Asp Lys 
            660                 665                 670         


<210>  967
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  967

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Glu 
1               5                   10                  15      


Thr Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser 
    50                  55                  60                  


Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
                85                  90                  95      


Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala 
            100                 105                 110         


Thr Ser Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
465                 470                 475                 480 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                485                 490                 495     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            500                 505                 510         


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        515                 520                 525             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    530                 535                 540                 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
545                 550                 555                 560 


Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Met Leu 
                565                 570                 575     


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
            580                 585                 590         


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
        595                 600                 605             


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
    610                 615                 620                 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
625                 630                 635                 640 


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
                645                 650                 655     


Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 


<210>  968
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  968

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
                565                 570                 575     


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
            580                 585                 590         


Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu 
        595                 600                 605             


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
    610                 615                 620                 


Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys 
625                 630                 635                 640 


Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Asp Tyr 
                645                 650                 655     


Lys Asp Asp Asp Asp Lys 
            660         


<210>  969
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  969

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Glu 
1               5                   10                  15      


Thr Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser 
    50                  55                  60                  


Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
                85                  90                  95      


Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala 
            100                 105                 110         


Thr Ser Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
465                 470                 475                 480 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                485                 490                 495     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            500                 505                 510         


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        515                 520                 525             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    530                 535                 540                 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
545                 550                 555                 560 


Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro 
            580                 585                 590         


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
        595                 600                 605             


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr 
    610                 615                 620                 


Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro 
625                 630                 635                 640 


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
                645                 650                 655     


Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro 
            660                 665                 670         


Leu Ser Ala Ile Phe Thr Thr 
        675                 


<210>  970
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  970

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Asp Tyr Lys 
            660                 665                 670         


Asp Asp Asp Asp Lys 
        675         


<210>  971
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  971

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Glu 
1               5                   10                  15      


Thr Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser 
    50                  55                  60                  


Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
                85                  90                  95      


Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala 
            100                 105                 110         


Thr Ser Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
465                 470                 475                 480 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                485                 490                 495     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            500                 505                 510         


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        515                 520                 525             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    530                 535                 540                 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
545                 550                 555                 560 


Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro 
            580                 585                 590         


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
        595                 600                 605             


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr 
    610                 615                 620                 


Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro 
625                 630                 635                 640 


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
                645                 650                 655     


Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro 
            660                 665                 670         


Leu Ser Ala Ile Phe Thr Thr Asp Tyr Lys Asp Asp Asp Asp Lys 
        675                 680                 685         


<210>  972
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  972

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu Val Gln Leu Val Glu 
1               5                   10                  15      


Thr Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            20                  25                  30          


Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser 
    50                  55                  60                  


Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
                85                  90                  95      


Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala 
            100                 105                 110         


Thr Ser Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
465                 470                 475                 480 


Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
                485                 490                 495     


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            500                 505                 510         


Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr 
        515                 520                 525             


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    530                 535                 540                 


Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser 
545                 550                 555                 560 


Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Met Leu 
                565                 570                 575     


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
            580                 585                 590         


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
        595                 600                 605             


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
    610                 615                 620                 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
625                 630                 635                 640 


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
                645                 650                 655     


Pro Leu Ser Ala Ile Phe Thr Thr Asp Tyr Lys Asp Asp Asp Asp Lys 
            660                 665                 670         


<210>  973
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  973

Asp Tyr Lys Asp Asp Asp Asp Lys Glu Val Gln Leu Val Glu Thr Gly 
1               5                   10                  15      


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala 
            20                  25                  30          


Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg Gln Ala 
        35                  40                  45              


Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser Gly Ser 
    50                  55                  60                  


Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu Gln Ala 
                85                  90                  95      


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala Thr Ser 
            100                 105                 110         


Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro 
465                 470                 475                 480 


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
                485                 490                 495     


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu 
            500                 505                 510         


Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro 
        515                 520                 525             


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
    530                 535                 540                 


Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro 
545                 550                 555                 560 


Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
            580                 585                 590         


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
        595                 600                 605             


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu 
    610                 615                 620                 


Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
625                 630                 635                 640 


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys 
                645                 650                 655     


Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser 
            660                 665                 670         


Ala Ile Phe Thr Thr 
        675         


<210>  974
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  974

Asp Tyr Lys Asp Asp Asp Asp Lys Glu Val Gln Leu Val Glu Thr Gly 
1               5                   10                  15      


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala 
            20                  25                  30          


Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg Gln Ala 
        35                  40                  45              


Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser Gly Ser 
    50                  55                  60                  


Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu Gln Ala 
                85                  90                  95      


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala Thr Ser 
            100                 105                 110         


Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro 
465                 470                 475                 480 


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
                485                 490                 495     


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu 
            500                 505                 510         


Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro 
        515                 520                 525             


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
    530                 535                 540                 


Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro 
545                 550                 555                 560 


Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro 
            580                 585                 590         


Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser 
        595                 600                 605             


Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu 
    610                 615                 620                 


Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
625                 630                 635                 640 


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys 
                645                 650                 655     


Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser 
            660                 665                 670         


Ala Ile Phe Thr Thr 
        675         


<210>  975
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  975

Asp Tyr Lys Asp Asp Asp Asp Lys Glu Val Gln Leu Val Glu Thr Gly 
1               5                   10                  15      


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala 
            20                  25                  30          


Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg Gln Ala 
        35                  40                  45              


Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser Gly Ser 
    50                  55                  60                  


Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu Gln Ala 
                85                  90                  95      


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala Thr Ser 
            100                 105                 110         


Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro 
465                 470                 475                 480 


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
                485                 490                 495     


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu 
            500                 505                 510         


Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro 
        515                 520                 525             


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
    530                 535                 540                 


Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro 
545                 550                 555                 560 


Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Met Leu Pro Ala 
                565                 570                 575     


Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu 
            580                 585                 590         


Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr 
        595                 600                 605             


Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly 
    610                 615                 620                 


Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr 
625                 630                 635                 640 


Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu 
                645                 650                 655     


Ser Ala Ile Phe Thr Thr 
            660         


<210>  976
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  976

Asp Tyr Lys Asp Asp Asp Asp Lys Glu Val Gln Leu Val Glu Thr Gly 
1               5                   10                  15      


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala 
            20                  25                  30          


Ser Arg Phe Ser Phe Arg Asp Tyr Tyr Met Thr Trp Ile Arg Gln Ala 
        35                  40                  45              


Pro Gly Lys Gly Pro Glu Trp Val Ser His Ile Ser Gly Ser Gly Ser 
    50                  55                  60                  


Thr Ile Tyr Tyr Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu Gln Ala 
                85                  90                  95      


Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Arg Ala Thr Ser 
            100                 105                 110         


Tyr Tyr Trp Val His Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro 
465                 470                 475                 480 


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
                485                 490                 495     


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu 
            500                 505                 510         


Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro 
        515                 520                 525             


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
    530                 535                 540                 


Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro 
545                 550                 555                 560 


Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Met Leu Pro Ala 
                565                 570                 575     


Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu 
            580                 585                 590         


Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr 
        595                 600                 605             


Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly 
    610                 615                 620                 


Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr 
625                 630                 635                 640 


Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu 
                645                 650                 655     


Ser Ala Ile Phe Thr Thr 
            660         


<210>  977
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  977

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Gly Phe Thr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg 
465                 470                 475                 480 


Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala 
                485                 490                 495     


Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu 
            500                 505                 510         


Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr 
        515                 520                 525             


Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys 
    530                 535                 540                 


Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555             


<210>  978
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  978

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
225                 230                 235                 240 


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
                245                 250                 255     


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu 
            260                 265                 270         


Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        275                 280                 285             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val 
    290                 295                 300                 


Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala 
305                 310                 315                 320 


Ile Phe Thr Thr 
                


<210>  979
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  979

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
225                 230                 235                 240 


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
                245                 250                 255     


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu 
            260                 265                 270         


Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        275                 280                 285             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val 
    290                 295                 300                 


Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala 
305                 310                 315                 320 


Ile Phe Thr Thr 
                


<210>  980
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  980

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys 
225                 230                 235                 240 


Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp 
                245                 250                 255     


Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu 
            260                 265                 270         


Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        275                 280                 285             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val 
    290                 295                 300                 


Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala 
305                 310                 315                 320 


Ile Phe Thr Thr 
                


<210>  981
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  981

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ile Ile 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
225                 230                 235                 240 


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
                245                 250                 255     


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile 
            260                 265                 270         


Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val 
        275                 280                 285             


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    290                 295                 300                 


Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser Asn 
305                 310                 315                 320 


Pro Leu Ser Ala Ile Phe Thr Thr 
                325             


<210>  982
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  982

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ile Ile 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
225                 230                 235                 240 


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
                245                 250                 255     


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
            260                 265                 270         


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
        275                 280                 285             


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    290                 295                 300                 


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
305                 310                 315                 320 


Pro Leu Ser Ala Ile Phe Thr Thr 
                325             


<210>  983
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  983

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Pro Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ile Ile 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
225                 230                 235                 240 


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
                245                 250                 255     


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile 
            260                 265                 270         


Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val 
        275                 280                 285             


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    290                 295                 300                 


Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr 
305                 310                 315                 320 


Pro Leu Ser Ala Ile Phe Thr Thr 
                325             


<210>  984
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  984

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Gly Ile Gly Tyr Leu Glu Tyr Pro Trp Tyr Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Asp Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly Trp Trp Ser Tyr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  985
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  985

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Asn Ile Asp Tyr Phe Glu Tyr Tyr Glu Phe Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Asp Ile Tyr Gly Val 
    530                 535                 540                 


Lys Gly Gly Ser Trp Ser Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  986
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  986

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Asn Ile His Tyr Ala Glu Tyr Pro Asp Phe Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Ile Val Asp Ile Trp Gly Val 
    530                 535                 540                 


Lys Gly Gly Leu Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  987
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  987

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Ala Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  988
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  988

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val 
    530                 535                 540                 


Lys Gly Gly His Ser Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                565                 570                 575     


Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            580                 585                 590         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        595                 600                 605             


Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala 
    610                 615                 620                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
625                 630                 635                 640 


Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly 
                645                 650                 655     


Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
            660                 665                 


<210>  989
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa at position 32 is Glu

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa at position 38 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa at position 39 is Trp or a functionally equivalent amino acid
       residue

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa at position 40 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa at position 41 is Trp

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa at position 42 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa at position 46 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  Xaa at position 66 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa at position 68 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa at position 70 is Phe

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa at position 72 is Gly

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa at positions 77-79 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (81)..(82)
<223>  Xaa at positions 81 and 82 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa at position 84 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa at position 86 is any amino acid residue

<400>  989

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Xaa Glu Ala Ile Xaa Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Xaa Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Xaa Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Xaa Leu Xaa Ala Xaa Phe Thr Thr 
                85                  


<210>  990
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa at position 34 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa at position 38 is Trp

<220>
<221>  MISC_FEATURE
<222>  (39)..(41)
<223>  Xaa at positions 39-41 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa at position 68 is Leu

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa at position 70 is Asp

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa at position 72 is Tyr

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  Xaa at position 78 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa at position 79 is Trp

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Xaa at position 81 is Tyr

<400>  990

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  991
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (75)..(76)
<223>  Xaa at positions 75 and 76 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Xaa at position 77 is Ile

<220>
<221>  MISC_FEATURE
<222>  (78)..(79)
<223>  Xaa at positions 78 and 79 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa at position 80 is Gly

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Xaa at position 81 is Trp

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa at position 82 is Leu

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa at position 83 is Asp

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa at position 84 is Phe

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa at position 85 is Val

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa at position 86 is Phe

<400>  991

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  992
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17 Consensus


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa at position 32 is Trp

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa at position 34 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa at position 36 is Glu

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa at position 38 is Lys

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa at position 39 is Phe

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa at position 40 is Tyr

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa at position 41 is Arg

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa at position 42 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa at position 46 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  Xaa at position 66 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa at position 68 is Lys

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa at position 70 is Trp

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa at position 72 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa at positions 77-79 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Xaa at position 81 is Trp

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa at position 82 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa at position 84 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa at position 86 is any amino acid residue

<400>  992

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Xaa Glu Ala Ile Xaa Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Xaa Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Xaa Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Xaa Leu Xaa Ala Xaa Phe Thr Thr 
                85                  


<210>  993
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26 C strand/CD loop region consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Glu

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Trp

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Trp

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is any amino acid residue

<400>  993

Asp Ser Phe Xaa Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Xaa Glu 
1               5                   10                  15  


<210>  994
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26 F strand and FG loop region consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Phe

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is Gly

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  Xaa at positions 13-15 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is any amino acid residue

<400>  994

Thr Xaa Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Xaa Xaa Xaa Ser 
1               5                   10                  15      


Xaa 
    


<210>  995
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27 C strand/CD loop region consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Trp

<220>
<221>  MISC_FEATURE
<222>  (11)..(13)
<223>  Xaa at positions 11-13 is any amino acid residue

<400>  995

Asp Ser Phe Xaa Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu 
1               5                   10                  15  


<210>  996
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Luk27 F strand and FG loop region consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Leu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Asp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is Tyr

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is Trp

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is Tyr

<400>  996

Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
1               5                   10                  15      


Xaa 
    


<210>  997
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Luk38 FG loop region consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa at positions 1 and 2 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Ile

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa at positions 4 and 5 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Gly

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is Trp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is Leu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is Asp

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Phe

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Val

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Phe

<400>  997

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  998
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17 C strand/CD loop region consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Trp

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Lys

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Phe

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Arg

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is any amino acid residue

<400>  998

Asp Ser Phe Xaa Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Xaa Glu 
1               5                   10                  15  


<210>  999
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17 F strand and FG loop region consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Lys

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is Trp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  Xaa at positions 13-15 is any amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at positions 17 is Trp

<400>  999

Thr Xaa Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Xaa Xaa Xaa Ser 
1               5                   10                  15      


Xaa 
    


<210>  1000
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  1000

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  1001
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  1001

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  1002
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  1002

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  1003
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  1003

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Arg Gly Ala Ser Gly Ile Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  1004
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  1004

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Arg Gly Ala Ser Gly Ile Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  1005
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  1005

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Arg Gly Ala Ser Gly Ile Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  1006
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  1006

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Arg Gly Ala Ser Gly Ile Asp Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  1007
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  1007

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Glu Leu Arg Ala Ser Trp Gly Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  1008
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1008

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Glu Leu Arg Ala Ser Trp Gly Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  1009
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1009

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Glu Leu Arg Ala Ser Trp Gly Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  1010
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  1010

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Glu Leu Arg Ala Ser Trp Gly Asp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  1011
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  1011

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Ile Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Trp Asn Phe Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  1012
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  1012

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  1013
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  1013

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  1014
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1014

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  1015
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1015

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ser Tyr Ser Gln Tyr Ser Gly Trp Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  1016
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  1016

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  1017
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Tencon

<400>  1017

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  1018
<211>  324
<212>  PRT
<213>  Artificial

<220>
<223>  LukA (PDB Entry 4tw1)

<400>  1018

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Ala Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  1019
<211>  332
<212>  PRT
<213>  Artificial

<220>
<223>  LukA (HDX)

<400>  1019

Asn Ser Ala His His His His His His Gly Ser His Lys Asp Ser Gln 
1               5                   10                  15      


Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln Lys Asp Lys 
            20                  25                  30          


Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro Asp Asp Ile 
        35                  40                  45              


Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val Tyr Asp Glu 
    50                  55                  60                  


Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile Asp Asp Pro 
65                  70                  75                  80  


Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly Ser Ile His 
                85                  90                  95      


Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn Ser Asn Trp 
            100                 105                 110         


Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val Lys Arg Asn 
        115                 120                 125             


Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys Ile Ser Thr 
    130                 135                 140                 


Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly Lys Phe Asp 
145                 150                 155                 160 


Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr Ser Lys Thr 
                165                 170                 175     


Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser Gly Lys Asn 
            180                 185                 190         


Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys Tyr 
        195                 200                 205             


Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg Asn 
    210                 215                 220                 


Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser Lys 
225                 230                 235                 240 


Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe Leu 
                245                 250                 255     


Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu Val 
            260                 265                 270         


Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile His 
        275                 280                 285             


Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu Ile 
    290                 295                 300                 


Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val Asp 
305                 310                 315                 320 


Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Ala Gly 
                325                 330         


<210>  1020
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  LukA (Loop Mutants)

<400>  1020

Met Asn Ser Ala His His His His His His Gly Ser His Lys Asp Ser 
1               5                   10                  15      


Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln Lys Asp 
            20                  25                  30          


Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro Asp Asp 
        35                  40                  45              


Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val Tyr Asp 
    50                  55                  60                  


Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile Asp Asp 
65                  70                  75                  80  


Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly Ser Ile 
                85                  90                  95      


His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn Ser Asn 
            100                 105                 110         


Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val Lys Arg 
        115                 120                 125             


Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys Ile Ser 
    130                 135                 140                 


Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly Lys Phe 
145                 150                 155                 160 


Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr Ser Lys 
                165                 170                 175     


Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser Gly Lys 
            180                 185                 190         


Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys 
        195                 200                 205             


Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg 
    210                 215                 220                 


Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser 
225                 230                 235                 240 


Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe 
                245                 250                 255     


Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu 
            260                 265                 270         


Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile 
        275                 280                 285             


His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu 
    290                 295                 300                 


Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val 
305                 310                 315                 320 


Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Ala Gly 
                325                 330             


<210>  1021
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  LukA (Point Mutants)

<400>  1021

Met Asn Ser Ala His His His His His His His His His His Gly Gly 
1               5                   10                  15      


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly 
            20                  25                  30          


Ser His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys 
        35                  40                  45              


Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser 
    50                  55                  60                  


Thr Ala Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr 
65                  70                  75                  80  


Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe 
                85                  90                  95      


Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys 
            100                 105                 110         


Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu 
        115                 120                 125             


Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp 
    130                 135                 140                 


Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro 
145                 150                 155                 160 


Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser 
                165                 170                 175     


Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser 
            180                 185                 190         


Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr 
        195                 200                 205             


Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile 
    210                 215                 220                 


Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu 
225                 230                 235                 240 


Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu 
                245                 250                 255     


Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly 
            260                 265                 270         


Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu 
        275                 280                 285             


Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys 
    290                 295                 300                 


Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys 
305                 310                 315                 320 


Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys 
                325                 330                 335     


Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys 
            340                 345                 350         


Ala Gly 
        


<210>  1022
<211>  299
<212>  PRT
<213>  Artificial

<220>
<223>  LukA mut3

<400>  1022

Met Asn Ser Ala His His His His His His Gly Ser His Lys Asp Ser 
1               5                   10                  15      


Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln Lys Asp 
            20                  25                  30          


Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro Asp Asp 
        35                  40                  45              


Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val Tyr Asp 
    50                  55                  60                  


Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile Asp Asp 
65                  70                  75                  80  


Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly Ser Ile 
                85                  90                  95      


His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn Ser Asn 
            100                 105                 110         


Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val Lys Arg 
        115                 120                 125             


Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys Ile Ser 
    130                 135                 140                 


Gly Gly Ser Gly Gly Asn Tyr Asp Thr Ile Ala Ser Gly Lys Asn Asn 
145                 150                 155                 160 


Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys Tyr Gly 
                165                 170                 175     


Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg Asn Thr 
            180                 185                 190         


Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser Lys Tyr 
        195                 200                 205             


Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe Leu Thr 
    210                 215                 220                 


Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu Val Thr 
225                 230                 235                 240 


Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile His Tyr 
                245                 250                 255     


Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu Ile Val 
            260                 265                 270         


Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val Asp Lys 
        275                 280                 285             


Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Ala Gly 
    290                 295                 


<210>  1023
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  LukA mut4

<400>  1023

Met Asn Ser Ala His His His His His His Gly Ser His Lys Asp Ser 
1               5                   10                  15      


Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln Lys Asp 
            20                  25                  30          


Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro Asp Asp 
        35                  40                  45              


Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val Tyr Asp 
    50                  55                  60                  


Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile Asp Asp 
65                  70                  75                  80  


Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly Ser Ile 
                85                  90                  95      


His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn Ser Asn 
            100                 105                 110         


Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val Lys Arg 
        115                 120                 125             


Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys Ile Ser 
    130                 135                 140                 


Gly Gly Ser Gly Asn Tyr Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn 
145                 150                 155                 160 


Trp His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly 
                165                 170                 175     


Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg 
            180                 185                 190         


Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg 
        195                 200                 205             


Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr 
    210                 215                 220                 


Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr 
225                 230                 235                 240 


Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile His Tyr Ala 
                245                 250                 255     


Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu Ile Val Thr 
            260                 265                 270         


Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val Asp Lys Tyr 
        275                 280                 285             


Ser Asp Asp Asn Lys Pro Tyr Lys Ala Gly 
    290                 295             


<210>  1024
<211>  297
<212>  PRT
<213>  Artificial

<220>
<223>  LukA mut5

<400>  1024

Met Asn Ser Ala His His His His His His Gly Ser His Lys Asp Ser 
1               5                   10                  15      


Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln Lys Asp 
            20                  25                  30          


Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro Asp Asp 
        35                  40                  45              


Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val Tyr Asp 
    50                  55                  60                  


Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile Asp Asp 
65                  70                  75                  80  


Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly Ser Ile 
                85                  90                  95      


His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn Ser Asn 
            100                 105                 110         


Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val Lys Arg 
        115                 120                 125             


Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gln Asn Tyr Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp 
145                 150                 155                 160 


His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu 
                165                 170                 175     


Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile 
            180                 185                 190         


Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr 
        195                 200                 205             


Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu 
    210                 215                 220                 


Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr 
225                 230                 235                 240 


Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro 
                245                 250                 255     


Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr 
            260                 265                 270         


Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser 
        275                 280                 285             


Asp Asp Asn Lys Pro Tyr Lys Ala Gly 
    290                 295         


<210>  1025
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  LukA mut6

<400>  1025

Met Asn Ser Ala His His His His His His Gly Ser His Lys Asp Ser 
1               5                   10                  15      


Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln Lys Asp 
            20                  25                  30          


Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro Asp Asp 
        35                  40                  45              


Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val Tyr Asp 
    50                  55                  60                  


Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile Asp Asp 
65                  70                  75                  80  


Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly Ser Ile 
                85                  90                  95      


His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn Ser Asn 
            100                 105                 110         


Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val Lys Arg 
        115                 120                 125             


Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gln Asn Tyr Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn 
145                 150                 155                 160 


Trp His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly 
                165                 170                 175     


Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg 
            180                 185                 190         


Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg 
        195                 200                 205             


Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr 
    210                 215                 220                 


Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr 
225                 230                 235                 240 


Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile His Tyr Ala 
                245                 250                 255     


Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu Ile Val Thr 
            260                 265                 270         


Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val Asp Lys Tyr 
        275                 280                 285             


Ser Asp Asp Asn Lys Pro Tyr Lys Ala Gly 
    290                 295             


<210>  1026
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  LukB (PDB Entry 4tw1)

<400>  1026

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp 
305 


<210>  1027
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  LukB (HDX)

<400>  1027

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  1028
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB (Mutants)

<400>  1028

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1029
<211>  274
<212>  PRT
<213>  Artificial

<220>
<223>  LukB mut3

<400>  1029

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
        115                 120                 125             


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
    130                 135                 140                 


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
145                 150                 155                 160 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
                165                 170                 175     


Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe 
            180                 185                 190         


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly 
        195                 200                 205             


Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
    210                 215                 220                 


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
225                 230                 235                 240 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
                245                 250                 255     


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
            260                 265                 270         


Lys Lys 
        


<210>  1030
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  LukB mut4

<400>  1030

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Gly 
            100                 105                 110         


Gly Ser Gly Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His Lys 
        115                 120                 125             


Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly His 
    130                 135                 140                 


Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys Ser 
145                 150                 155                 160 


Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp Asn 
                165                 170                 175     


Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe Asn 
            180                 185                 190         


Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly Lys 
        195                 200                 205             


Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys Ile 
    210                 215                 220                 


Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn His 
225                 230                 235                 240 


Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp Trp 
                245                 250                 255     


Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu Lys 
            260                 265                 270         


Lys 
    


<210>  1031
<211>  274
<212>  PRT
<213>  Artificial

<220>
<223>  LukB mut5

<400>  1031

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Gly 
            100                 105                 110         


Gly Ser Gly Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
        115                 120                 125             


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
    130                 135                 140                 


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
145                 150                 155                 160 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
                165                 170                 175     


Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe 
            180                 185                 190         


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly 
        195                 200                 205             


Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
    210                 215                 220                 


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
225                 230                 235                 240 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
                245                 250                 255     


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
            260                 265                 270         


Lys Lys 
        


<210>  1032
<211>  272
<212>  PRT
<213>  Artificial

<220>
<223>  LukB mut6

<400>  1032

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Ser Gly Gly Ser 
            100                 105                 110         


Gly Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His Lys Gly 
        115                 120                 125             


Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly His Asp 
    130                 135                 140                 


His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys Ser Glu 
145                 150                 155                 160 


Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp Asn Phe 
                165                 170                 175     


Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe Asn Pro 
            180                 185                 190         


Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly Lys Ser 
        195                 200                 205             


Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys Ile Asp 
    210                 215                 220                 


Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn His Val 
225                 230                 235                 240 


Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp Trp Lys 
                245                 250                 255     


Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu Lys Lys 
            260                 265                 270         


<210>  1033
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_Y74A

<400>  1033

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Ala Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1034
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_W75A

<400>  1034

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Ala Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1035
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_R194A

<400>  1035

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Ala Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1036
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_K196A

<400>  1036

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Ala Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1037
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_R204A

<400>  1037

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Ala Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1038
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_N205A

<400>  1038

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Ala Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1039
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_N207A

<400>  1039

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Ala Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1040
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_W209A

<400>  1040

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Ala Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1041
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_D262A

<400>  1041

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Ala Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1042
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_D262R

<400>  1042

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Arg Trp Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1043
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_W263A

<400>  1043

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Ala Asn Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1044
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_N264A

<400>  1044

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Ala Arg His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1045
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_R265A

<400>  1045

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Ala His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1046
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_R265E

<400>  1046

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Glu His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1047
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_H266A

<400>  1047

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg Ala Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1048
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_G267R

<400>  1048

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Arg Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1049
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_G267A

<400>  1049

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Ala Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1050
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_F268A

<400>  1050

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Ala Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1051
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_W269A

<400>  1051

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Ala Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1052
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  LukB_Y271A

<400>  1052

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln 
145                 150                 155                 160 


Ser Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asn Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Lys Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Ala Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu 
    290                 295                 300                 


Asn Asp Asn Glu Lys Lys 
305                 310 


<210>  1053
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17

<400>  1053

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His 
        


<210>  1054
<211>  311
<212>  PRT
<213>  Artificial

<220>
<223>  LukE (PDB Entry 3rohA)

<400>  1054

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  1055
<211>  294
<212>  PRT
<213>  Artificial

<220>
<223>  LukE (HDX)

<400>  1055

Asn Ser Ala His His His His His His Gly Ser Asn Thr Asn Ile Glu 
1               5                   10                  15      


Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val Ser 
            20                  25                  30          


Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val Lys 
        35                  40                  45              


Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly Phe 
    50                  55                  60                  


Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr Glu 
65                  70                  75                  80  


Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr 
                85                  90                  95      


Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
            100                 105                 110         


Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly 
        115                 120                 125             


Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr 
    130                 135                 140                 


Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val Asp 
145                 150                 155                 160 


Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu Phe 
                165                 170                 175     


Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe Val 
            180                 185                 190         


Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala Pro 
        195                 200                 205             


Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe 
    210                 215                 220                 


Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe 
225                 230                 235                 240 


Glu Leu Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu Phe 
                245                 250                 255     


Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val Asn 
            260                 265                 270         


Arg Asn Phe Val Val Arg Tyr Lys Val Asn Trp Lys Thr His Glu Ile 
        275                 280                 285             


Lys Val Lys Gly His Asn 
    290                 


<210>  1056
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE (Mutants)

<400>  1056

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1057
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_S105A

<400>  1057

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ala Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1058
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_V107A

<400>  1058

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Ala Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1059
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_K108A

<400>  1059

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Ala Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1060
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_G109R

<400>  1060

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Arg Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1061
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_Y112A

<400>  1061

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Ala 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1062
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_L114A

<400>  1062

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Ala Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1063
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_T115A

<400>  1063

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Ala Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1064
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_R117A

<400>  1064

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Ala Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1065
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_I283A

<400>  1065

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ala Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1066
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_Y285A

<400>  1066

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Ala Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1067
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_T287A

<400>  1067

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Ala Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1068
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_F289A

<400>  1068

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Ala Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1069
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_T292A

<400>  1069

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Ala Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1070
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_Y295A

<400>  1070

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Ala Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1071
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_E297A

<400>  1071

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Ala Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1072
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_K299A

<400>  1072

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Ala His Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1073
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_H300A

<400>  1073

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys Ala Asn Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1074
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_N301A

<400>  1074

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Ala Ala Phe Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1075
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_F303A

<400>  1075

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Ala Val 
    290                 295                 300                 


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1076
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  LukE_R306A

<400>  1076

Met Gly Ser Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Gly His His His His His His His His His His Ser 
            20                  25                  30          


Ser Gly Leu Val Pro Arg Gly Ser His Met Leu Glu Asn Thr Asn Ile 
        35                  40                  45              


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
    50                  55                  60                  


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
65                  70                  75                  80  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
                85                  90                  95      


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
            100                 105                 110         


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
        115                 120                 125             


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
    130                 135                 140                 


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
145                 150                 155                 160 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
                165                 170                 175     


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
            180                 185                 190         


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
        195                 200                 205             


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
    210                 215                 220                 


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
225                 230                 235                 240 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
                245                 250                 255     


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
            260                 265                 270         


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
        275                 280                 285             


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
    290                 295                 300                 


Asn Ala Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
305                 310                 315                 320 


Ile Lys Val Lys Gly His Asn 
                325         


<210>  1077
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26

<400>  1077

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn 
65                  70                  75                  80  


Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His 
        


<210>  1078
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  LukABHC111

<400>  1078

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Leu Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Gly Tyr Asp Tyr Asp Gly Glu Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
        115                 120                 125             


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
    130                 135                 140                 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Glu Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
            180                 185                 190         


Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
    210                 215                 220                 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
                245                 250                 255     


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
        275                 280                 285             


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
    290                 295                 300                 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
            340                 345                 350         


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
        355                 360                 365             


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
    370                 375                 380                 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn 
385                 390                 395                 400 


Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
                405                 410                 415     


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
            420                 425                 430         


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445             


<210>  1079
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  LukABLC111

<400>  1079

Asp Ile Val Met Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ile Thr Ile Thr Cys Ser Ala His Ser Asn Leu Ile Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ser Ile Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser 
        115                 120                 125             


Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val 
145                 150                 155                 160 


Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser 
            180                 185                 190         


Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys 
        195                 200                 205             


Ser Phe Asn Arg Asn Glu Cys 
    210                 215 


<210>  1080
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  FabHC214

<400>  1080

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Leu Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Gly Tyr Asp Tyr Asp Gly Glu Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys His His His His His His 
225                 230             


<210>  1081
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  FabLC214

<400>  1081

Asp Ile Val Met Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ile Thr Ile Thr Cys Ser Ala His Ser Asn Leu Ile Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ser Ile Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  1082
<211>  229
<212>  PRT
<213>  Artificial

<220>
<223>  FabHC229

<400>  1082

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys His 
    210                 215                 220                 


His His His His His 
225                 


<210>  1083
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  FabLC229

<400>  1083

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  1084
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  TD peptide

<400>  1084

Thr Asp Thr Asp Thr Asp Thr Asp Thr Asp Thr Asp Thr Asp Thr Asp 
1               5                   10                  15      


Thr Asp Thr Asp His His His His His His His His 
            20                  25              


<210>  1085
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  SD-GlcNAc peptide

<400>  1085

Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp Ser Asp 
1               5                   10                  15      


Ser Asp Ser Asp His His His His His His His His 
            20                  25              


<210>  1086
<211>  325
<212>  PRT
<213>  Artificial

<220>
<223>  Hla H35L toxoid

<400>  1086

Met Lys Thr Arg Ile Val Ser Ser Val Thr Thr Thr Leu Leu Leu Gly 
1               5                   10                  15      


Ser Ile Leu Met Asn Pro Val Ala Asn Ala Ala Asp Ser Asp Ile Asn 
            20                  25                  30          


Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser Asn Thr Thr Val Lys Thr 
        35                  40                  45              


Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn Gly Met Leu Lys Lys Val 
    50                  55                  60                  


Phe Tyr Ser Phe Ile Asp Asp Lys Asn His Asn Lys Lys Leu Leu Val 
65                  70                  75                  80  


Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln Tyr Arg Val Tyr Ser Glu 
                85                  90                  95      


Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp Pro Ser Ala Phe Lys Val 
            100                 105                 110         


Gln Leu Gln Leu Pro Asp Asn Glu Val Ala Gln Ile Ser Asp Tyr Tyr 
        115                 120                 125             


Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr Met Ser Thr Leu Thr Tyr 
    130                 135                 140                 


Gly Phe Asn Gly Asn Val Thr Gly Asp Asp Thr Gly Lys Ile Gly Gly 
145                 150                 155                 160 


Leu Ile Gly Ala Asn Val Ser Ile Gly His Thr Leu Lys Tyr Val Gln 
                165                 170                 175     


Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro Thr Asp Lys Lys Val Gly 
            180                 185                 190         


Trp Lys Val Ile Phe Asn Asn Met Val Asn Gln Asn Trp Gly Pro Tyr 
        195                 200                 205             


Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly Asn Gln Leu Phe Met Lys 
    210                 215                 220                 


Thr Arg Asn Gly Ser Met Lys Ala Ala Asp Asn Phe Leu Asp Pro Asn 
225                 230                 235                 240 


Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe Ser Pro Asp Phe Ala Thr 
                245                 250                 255     


Val Ile Thr Met Asp Arg Lys Ala Ser Lys Gln Gln Thr Asn Ile Asp 
            260                 265                 270         


Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr Gln Leu His Trp Thr Ser 
        275                 280                 285             


Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp Lys Trp Ile Asp Arg Ser 
    290                 295                 300                 


Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys Glu Glu Met Thr Asn His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  1087
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk957 Hla binding FN3 domain

<400>  1087

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Glu Ala Pro Ile Trp Val Ala Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Phe Gln Pro Asn 
65                  70                  75                  80  


Asn Phe His Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  1088
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk958 Hla binding FN3 domain

<400>  1088

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Ala Asn Ala Trp Asp Asp Val Asn Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Arg Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Asn Gln 
65                  70                  75                  80  


Thr His Tyr Arg Trp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  1089
<211>  91
<212>  PRT
<213>  Artificial

<220>
<223>  Luk959 Hla binding FN3 domain

<400>  1089

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Tyr Ile Phe Pro Ile Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Gln Tyr Phe Glu Phe 
65                  70                  75                  80  


Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90      


<210>  1090
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk960 Hla binding FN3 domain

<400>  1090

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Ser Glu Glu Leu Phe Leu Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Ile Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Gly His Trp Asp 
65                  70                  75                  80  


Trp Tyr Trp Lys Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1091
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk961 Hla binding FN3 domain

<400>  1091

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Ser Glu Glu Leu Phe Leu Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Gly His Trp Asp 
65                  70                  75                  80  


Trp Tyr Trp Lys Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1092
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk962 Hla binding FN3 domain

<400>  1092

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Val Glu His Glu Phe Asp Ser Phe Leu Ile 
            20                  25                  30          


Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Asp Ser Gln Trp Tyr Phe 
65                  70                  75                  80  


Trp Arg Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  1093
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk963 Hla binding FN3 domain

<400>  1093

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Glu Glu Val His Trp Leu Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Ser Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Gly Tyr Ala His 
65                  70                  75                  80  


Trp Phe Thr Thr Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1094
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk964 Hla binding FN3 domain

<400>  1094

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Pro Ser His Phe Pro Arg Ser Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Thr Val Ala 
65                  70                  75                  80  


Thr Ile Arg Trp Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1095
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk965 Hla binding FN3 domain

<400>  1095

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Glu Gln Leu Trp Ile Gln Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Pro Trp Leu Pro 
65                  70                  75                  80  


Asn Tyr Trp Gln Val Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1096
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk966 Hla binding FN3 domain

<400>  1096

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Trp Ser Glu Asn Trp Val Asn Trp Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Glu Val Lys 
65                  70                  75                  80  


Asn Arg Ile Arg Trp Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  1097
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk967 Hla binding FN3 domain

<400>  1097

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Ala Asn Ala Trp Asp Asp Val Asn Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Asn Gln 
65                  70                  75                  80  


Thr His Tyr Arg Trp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  1098
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk968 Hla binding FN3 domain

<400>  1098

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Asp Lys Arg His Pro Asp Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Gly Phe Leu Gln 
65                  70                  75                  80  


Trp Tyr Trp Ser Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1099
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk969 Hla binding FN3 domain

<400>  1099

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Ser Glu Ile Ala Glu Gln Phe Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Gly His 
65                  70                  75                  80  


Trp Asp Trp Tyr Trp Lys Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  1100
<211>  93
<212>  PRT
<213>  Artificial

<220>
<223>  Luk970 Hla binding FN3 domain

<400>  1100

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Arg Gly Leu Ile Pro Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Leu Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gly Thr Tyr Tyr Pro Trp 
65                  70                  75                  80  


Trp Pro Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90              


<210>  1101
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk971 Hla binding FN3 domain

<400>  1101

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ser Pro Trp Phe Phe Gly Gln Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Glu Leu Gly Gln 
65                  70                  75                  80  


Gln Tyr Ser Phe Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1102
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk972 Hla binding FN3 domain

<400>  1102

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asn Ser Glu Ile Ala Glu Gln Phe Phe Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Gly His 
65                  70                  75                  80  


Trp Asp Trp Tyr Trp Lys Thr Ser Asn Pro Leu Ser Ala Ile Val Thr 
                85                  90                  95      


Thr 
    


<210>  1103
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk973 Hla binding FN3 domain

<400>  1103

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Gly Tyr Pro Glu Phe Tyr Arg Lys Gly Glu Ala Ile Gln Leu Arg 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ser Asp Leu Thr Thr His 
65                  70                  75                  80  


Trp Trp Leu Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  1104
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk974 Hla binding FN3 domain

<400>  1104

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Glu Glu Val His Trp Leu Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Gly Tyr Ala His 
65                  70                  75                  80  


Trp Phe Thr Thr Trp Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1105
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk975 Hla binding FN3 domain

<400>  1105

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Ser Tyr Gln Glu Leu Asp Pro Glu Gly Glu Ala Ile Asn Leu Ser 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Lys Tyr Leu Val Thr Ile Asp Gly Val Lys Gly Gly Lys Ala Ser 
65                  70                  75                  80  


Lys Pro Leu Pro Ala Asn Phe Thr Thr 
                85                  


<210>  1106
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk976 Hla binding FN3 domain

<400>  1106

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Thr Leu Thr Pro Trp Ile Ile Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Gln Pro Trp Gln 
65                  70                  75                  80  


Val Tyr Tyr Gln Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1107
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Luk977 Hla binding FN3 domain

<400>  1107

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gly Ala Ser Ile Glu Arg Ser Arg Trp Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Gln 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val 
65                  70                  75                  80  


Pro Asn Leu Phe Val Gln Gly Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  1108
<211>  92
<212>  PRT
<213>  Artificial

<220>
<223>  Luk978 Hla binding FN3 domain

<400>  1108

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Ala Tyr His Phe Ile Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Arg Ser Asp Tyr Val Tyr 
65                  70                  75                  80  


Trp Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  1109
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk979 Hla binding FN3 domain

<400>  1109

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Gln Ile Phe Pro Ala Phe Ala Arg Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Phe Gly Pro 
65                  70                  75                  80  


His Thr Phe Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  1110
<211>  91
<212>  PRT
<213>  Artificial

<220>
<223>  Luk980 Hla binding FN3 domain

<400>  1110

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Arg Ile Ser Phe Pro His Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Arg Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Trp Tyr Trp Arg Ala 
65                  70                  75                  80  


Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90      


<210>  1111
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk981 Hla binding FN3 domain

<400>  1111

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Ala Asn Ala Trp Asp Asp Val Asn Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Asp Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Asn Gln 
65                  70                  75                  80  


Thr His Tyr Arg Trp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  1112
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk982 Hla binding FN3 domain

<400>  1112

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Gly Tyr Pro Glu Tyr His Asp Ala Gly Glu Ala Ile His Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Ala Ile Arg Gly Val Lys Gly Gly His Ala Ser 
65                  70                  75                  80  


Glu Pro Leu His Ala His Phe Thr Thr 
                85                  


<210>  1113
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk983 Hla binding FN3 domain

<400>  1113

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Asn Gly Val Phe Glu Val Asn Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Asn Gln 
65                  70                  75                  80  


Thr His Tyr Arg Trp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  1114
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk984 Hla binding FN3 domain

<400>  1114

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Phe Val Thr Trp Arg Asn Gly Phe Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val His Gln Tyr 
65                  70                  75                  80  


Tyr Pro His Tyr Trp Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  1115
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Luk985 Hla binding FN3 domain

<400>  1115

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Lys Arg Asn Gly Val Phe Glu Val Asn Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Arg Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Trp Asn Gln 
65                  70                  75                  80  


Thr His Tyr Arg Trp Pro Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  1116
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  Luk986 Hla binding FN3 domain

<400>  1116

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Thr Leu Leu Phe Asn 
65                  70                  75                  80  


Gly Ala Val Leu Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  


<210>  1117
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk987 Hla binding FN3 domain

<400>  1117

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Val Asp Lys Arg His Pro Asp Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Ser Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Gly Phe Leu Gln 
65                  70                  75                  80  


Trp Tyr Trp Ser Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1118
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Luk988 Hla binding FN3 domain

<400>  1118

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Ala Pro Ser His Phe Pro Arg Ser Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Thr Val Ala 
65                  70                  75                  80  


Thr Ile Arg Trp Gln Ser Asp Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  1119
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk989 Hla binding FN3 domain

<400>  1119

Leu Pro Ala Pro Lys Asn Leu Phe Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Phe 
            20                  25                  30          


Ile Arg Tyr Val Glu Tyr Gly Gln Pro Gly Glu Ala Ile Pro Leu Asp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Gly Val Ser Ile Asn Gly Val Lys Gly Gly Asn Arg Ser 
65                  70                  75                  80  


Ser Pro Leu Phe Ala Arg Phe Thr Thr 
                85                  


<210>  1120
<211>  87
<212>  PRT
<213>  Artificial

<220>
<223>  Luk990 Hla binding FN3 domain

<400>  1120

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Ser Tyr Lys Glu Trp Trp Ala Val Gly Glu Ala Ile Phe Leu His 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Pro Ile Ser Gly Val Lys Gly Gly Asp Lys Ser 
65                  70                  75                  80  


Leu Pro Ala His Phe Thr Thr 
                85          


<210>  1121
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk991 Hla binding FN3 domain

<400>  1121

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile His Tyr Gly Glu Leu Trp Trp Asn Gly Glu Ala Ile Ala Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val Trp Ile Pro Gly Val Lys Gly Gly Ser Gln Ser 
65                  70                  75                  80  


Lys Pro Leu Trp Ala Phe Phe Thr Thr 
                85                  


<210>  1122
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk992 Hla binding FN3 domain

<400>  1122

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Tyr Tyr Val Glu Lys Pro Asp Pro Gly Glu Ala Ile Glu Leu Tyr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Arg Ile Glu Gly Val Lys Gly Gly Asp His Ser 
65                  70                  75                  80  


Phe Pro Leu Val Ala Gly Phe Thr Thr 
                85                  


<210>  1123
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk993 Hla binding FN3 domain

<400>  1123

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Glu Tyr Trp Glu Glu Arg Gln Arg Gly Glu Ala Ile Gly Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Ile Ile Val Gly Val Lys Gly Gly Thr Tyr Ser 
65                  70                  75                  80  


Val Pro Leu Glu Ala Phe Phe Thr Thr 
                85                  


<210>  1124
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk994 Hla binding FN3 domain

<400>  1124

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Glu Tyr His Glu Pro Ser Lys Trp Gly Glu Ala Ile Gly Leu Asn 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Gln Ile Lys Gly Val Lys Gly Gly Trp Trp Ser 
65                  70                  75                  80  


His Pro Leu Pro Ala Ala Phe Thr Thr 
                85                  


<210>  1125
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Luk995 Hla binding FN3 domain

<400>  1125

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Lys Tyr Gly Glu Gly Asn His Gly Glu Ala Ile Trp Leu Phe Val 
        35                  40                  45              


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
    50                  55                  60                  


Glu Tyr Tyr Val Glu Ile Val Gly Val Lys Gly Gly Phe Pro Ser Gln 
65                  70                  75                  80  


Pro Leu His Ala Gln Phe Thr Thr 
                85              


<210>  1126
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk996 Hla binding FN3 domain

<400>  1126

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Lys 
            20                  25                  30          


Ile Asp Tyr Ile Glu Ile Asp Val Glu Gly Glu Ala Ile Tyr Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Phe Arg Val Arg Ile Pro Gly Val Lys Gly Gly Asp His Ser 
65                  70                  75                  80  


Val Pro Leu Ala Ala Ala Phe Thr Thr 
                85                  


<210>  1127
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk997 Hla binding FN3 domain

<400>  1127

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ile 
            20                  25                  30          


Ile Ser Tyr Pro Glu Tyr Trp Ala Ile Gly Glu Ala Ile Pro Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ile Ile Pro Gly Val Lys Gly Gly Lys Gly Ser 
65                  70                  75                  80  


Asn Pro Leu Trp Ala Ile Phe Thr Thr 
                85                  


<210>  1128
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk998 Hla binding FN3 domain

<400>  1128

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile Gly Tyr Phe Ala Glu Val Asp Pro Gly Glu Ala Ile Gln Leu Asp 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ala Val Asn Ile Pro Gly Val Lys Gly Gly Tyr Lys Ser 
65                  70                  75                  80  


Asp Pro Leu Asn Ala His Ser Thr Thr 
                85                  


<210>  1129
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk999 Hla binding FN3 domain

<400>  1129

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Val Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Pro Tyr Gln Glu Leu Asn Arg Lys Gly Glu Ala Ile Gln Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Ser Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Lys Val His Ile Arg Gly Val Lys Gly Gly Lys Gln Ser 
65                  70                  75                  80  


Leu Pro Leu Ile Ala Gly Phe Thr Thr 
                85                  


<210>  1130
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1000 Hla binding FN3 domain

<400>  1130

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Glu 
            20                  25                  30          


Ile Thr Tyr His Glu Ile Tyr Lys Phe Gly Glu Ala Ile Thr Leu Gln 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Arg Ile Thr Gly Val Lys Gly Gly Trp Lys Ser 
65                  70                  75                  80  


Gln Pro Leu Val Ala Lys Phe Thr Thr 
                85                  


<210>  1131
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1001 Hla binding FN3 domain

<400>  1131

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Arg Tyr Asp Glu Glu Gly Tyr Trp Gly Glu Ala Ile Pro Leu His 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Trp Ile Tyr Gly Val Lys Gly Gly Arg Lys Ser 
65                  70                  75                  80  


Val Pro Leu Val Ala Glu Phe Thr Thr 
                85                  


<210>  1132
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1002 Hla binding FN3 domain

<400>  1132

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Arg Tyr Lys Glu Pro His Arg Gln Gly Glu Ala Ile Pro Leu Ile 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asn Val His Ile His Gly Val Lys Gly Gly Lys Trp Ser 
65                  70                  75                  80  


Ile Pro Leu Tyr Ala Trp Phe Thr Thr 
                85                  


<210>  1133
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1003 Hla binding FN3 domain

<400>  1133

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp 
            20                  25                  30          


Ile Ser Tyr Trp Glu Gln Val Trp Gln Gly Glu Ala Ile Val Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val Phe Ile Arg Gly Val Lys Gly Gly Ser Gln Ser 
65                  70                  75                  80  


Gly Pro Leu Arg Ala Phe Phe Thr Thr 
                85                  


<210>  1134
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1004 Hla binding FN3 domain

<400>  1134

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr 
            20                  25                  30          


Ile Tyr Tyr Tyr Glu Phe Phe Arg Asn Gly Glu Ala Ile Val Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Trp Val Arg Ile Lys Gly Val Lys Gly Gly Arg Asp Ser 
65                  70                  75                  80  


His Pro Leu Tyr Ala Gly Phe Thr Thr 
                85                  


<210>  1135
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1005 Hla binding FN3 domain

<400>  1135

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ser 
            20                  25                  30          


Ile Gly Tyr His Glu Val Gln Gln Thr Gly Glu Ala Ile Arg Leu Phe 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Glu Val Glu Ile Arg Gly Val Lys Gly Gly Thr Thr Ser 
65                  70                  75                  80  


Ile Pro Leu Trp Ala His Phe Thr Thr 
                85                  


<210>  1136
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1006 Hla binding FN3 domain

<400>  1136

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Thr Tyr Glu Glu Pro His Glu Ile Gly Glu Ala Ile Phe Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Glu Ile Gln Gly Val Lys Gly Gly Asp Pro Ser 
65                  70                  75                  80  


Asp Pro Leu Asn Ala Ala Phe Thr Thr 
                85                  


<210>  1137
<211>  90
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1007 Hla binding FN3 domain

<400>  1137

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile His Tyr Arg Glu Trp Ser Ile Trp Gly Glu Ala Ile Asp Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ile Ile Pro Gly Val Lys Gly Gly Tyr Val Ser 
65                  70                  75                  80  


Asn Pro Leu Phe Ala Phe Phe Thr Thr Thr 
                85                  90  


<210>  1138
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1008 Hla binding FN3 domain

<400>  1138

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His 
            20                  25                  30          


Ile Tyr Tyr Ser Glu Arg Gln Arg Ile Gly Glu Ala Ile Ile Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Lys Ile Asn Gly Val Lys Gly Gly Ile Ile Ser 
65                  70                  75                  80  


Gln Pro Leu Ile Ala Pro Phe Thr Thr 
                85                  


<210>  1139
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1009 Hla binding FN3 domain

<400>  1139

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn 
            20                  25                  30          


Ile Thr Tyr Val Glu Pro Val Thr Glu Gly Glu Ala Ile Ser Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ser Val Lys Ile His Gly Val Lys Gly Gly Pro Ala Ser 
65                  70                  75                  80  


Asn Pro Leu Tyr Ala Lys Phe Thr Thr 
                85                  


<210>  1140
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1010 Hla binding FN3 domain

<400>  1140

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Lys 
            20                  25                  30          


Ile Lys Tyr Lys Glu Glu Arg His Ile Gly Glu Ala Ile His Leu Gly 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Glu Val Tyr Ile Val Gly Val Lys Gly Gly Ser Ser Ser 
65                  70                  75                  80  


Ser Pro Leu Phe Ala His Phe Thr Thr 
                85                  


<210>  1141
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1011 Hla binding FN3 domain

<400>  1141

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg 
            20                  25                  30          


Ile Thr Tyr Trp Glu Asp Asn Ser Thr Gly Glu Ala Ile Leu Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Arg Val Ala Ile Val Gly Val Lys Gly Gly Asp Asp Ser 
65                  70                  75                  80  


Trp Pro Leu Leu Ala Thr Phe Thr Thr 
                85                  


<210>  1142
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1012 Hla binding FN3 domain

<400>  1142

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Phe 
            20                  25                  30          


Ile Leu Tyr Val Glu Tyr Ser Val Asn Gly Glu Ala Ile Glu Leu Ser 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Asp Val Ile Ile Gly Gly Val Lys Gly Gly Asn His Ser 
65                  70                  75                  80  


Lys Pro Leu Val Ala Phe Phe Thr Thr 
                85                  


<210>  1143
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1013 Hla binding FN3 domain

<400>  1143

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile His Tyr Arg Glu Trp Phe Ile Trp Gly Glu Ala Ile Asp Leu Val 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Ile Ile Pro Gly Val Lys Gly Gly Tyr Val Ser 
65                  70                  75                  80  


Asn Pro Leu Phe Ala Phe Phe Thr Thr 
                85                  


<210>  1144
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1014 Hla binding FN3 domain

<400>  1144

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Gly Tyr Arg Glu Leu Gly Gly Leu Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Tyr Val Val Ile Pro Gly Val Lys Gly Gly Gly Leu Ser 
65                  70                  75                  80  


Leu Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  1145
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1015 Hla binding FN3 domain

<400>  1145

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Leu Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Pro Tyr Arg Glu Leu Gly Arg Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Tyr Ile Thr Gly Val Lys Gly Gly Met Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  1146
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1016 Hla binding FN3 domain

<400>  1146

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Pro Tyr Arg Glu Leu Gly Arg Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Tyr Ile Thr Gly Val Lys Gly Gly Met Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  1147
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1017 Hla binding FN3 domain

<400>  1147

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp 
            20                  25                  30          


Ile His Tyr Arg Glu Val Pro Val Pro Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Phe Val Tyr Ile Met Gly Val Lys Gly Gly Thr Phe Ser 
65                  70                  75                  80  


Ala Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  1148
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Luk1018 Hla binding FN3 domain

<400>  1148

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Cys Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly 
            20                  25                  30          


Ile Pro Tyr Arg Glu Leu Gly Arg Gly Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Val Val Tyr Ile Thr Gly Val Lys Gly Gly Met Ile Ser 
65                  70                  75                  80  


Thr Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  1149
<211>  348
<212>  PRT
<213>  Artificial

<220>
<223>  LukA mut1

<400>  1149

Met Asn Ser Ala His His His His His His His His His His Gly Gly 
1               5                   10                  15      


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly 
            20                  25                  30          


Ser His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys 
        35                  40                  45              


Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser 
    50                  55                  60                  


Thr Ala Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr 
65                  70                  75                  80  


Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe 
                85                  90                  95      


Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys 
            100                 105                 110         


Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu 
        115                 120                 125             


Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp 
    130                 135                 140                 


Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro 
145                 150                 155                 160 


Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Lys Phe Asp 
                165                 170                 175     


Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr Ser Lys Thr 
            180                 185                 190         


Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser Gly Lys Asn 
        195                 200                 205             


Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp Leu Lys Tyr 
    210                 215                 220                 


Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe Tyr Arg Asn 
225                 230                 235                 240 


Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe Ala Ser Lys 
                245                 250                 255     


Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro Glu Phe Leu 
            260                 265                 270         


Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln Phe Glu Val 
        275                 280                 285             


Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro Gly Ile His 
    290                 295                 300                 


Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln Arg Leu Ile 
305                 310                 315                 320 


Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys Val Val Asp 
                325                 330                 335     


Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Ala Gly 
            340                 345             


<210>  1150
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  LukB mut1

<400>  1150

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Ile Asn Arg Gly Gly Leu 
        115                 120                 125             


Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser Tyr 
    130                 135                 140                 


Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His Lys 
145                 150                 155                 160 


Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly His 
                165                 170                 175     


Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys Ser 
            180                 185                 190         


Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp Asn 
        195                 200                 205             


Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe Asn 
    210                 215                 220                 


Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly Lys 
225                 230                 235                 240 


Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys Ile 
                245                 250                 255     


Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn His 
            260                 265                 270         


Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp Trp 
        275                 280                 285             


Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu Lys 
    290                 295                 300                 


Lys 
305 


<210>  1151
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  LukB mut2

<400>  1151

Met Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp 
1               5                   10                  15      


Gly Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln 
            20                  25                  30          


Lys Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn 
        35                  40                  45              


Tyr Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser 
    50                  55                  60                  


Gly Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg 
65                  70                  75                  80  


Trp Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn 
                85                  90                  95      


Asn Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser Tyr 
    130                 135                 140                 


Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His Lys 
145                 150                 155                 160 


Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly His 
                165                 170                 175     


Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys Ser 
            180                 185                 190         


Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp Asn 
        195                 200                 205             


Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe Asn 
    210                 215                 220                 


Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly Lys 
225                 230                 235                 240 


Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys Ile 
                245                 250                 255     


Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn His 
            260                 265                 270         


Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp Trp 
        275                 280                 285             


Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu Lys 
    290                 295                 300                 


Lys 
305 


<210>  1152
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  TENCON_HIS_SA

<400>  1152

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg 
65                  70                  75                  80  


Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            100                 105                 110         


Trp His Glu 
        115 


<210>  1153
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Luk17_HIS_SA

<400>  1153

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            100                 105                 110         


Trp His Glu 
        115 


<210>  1154
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Luk19_HIS_SA

<400>  1154

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Tyr His Ala Ile His Arg Leu Asn His Phe 
            20                  25                  30          


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
        35                  40                  45              


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Ala Gly 
    50                  55                  60                  


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Pro 
65                  70                  75                  80  


Asp Ala Phe Val Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90                  95      


Gly His His His His His His Gly Gly Gly Leu Asn Asp Ile Phe Glu 
            100                 105                 110         


Ala Gln Lys Ile Glu Trp His Glu 
        115                 120 


<210>  1155
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Luk26_HIS_SA

<400>  1155

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn 
65                  70                  75                  80  


Ser Thr Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            100                 105                 110         


Trp His Glu 
        115 


<210>  1156
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Luk31_HIS_SA

<400>  1156

Met Leu Pro Ala Pro Asn Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Asp Trp Asp Lys Tyr Tyr Thr Asn Arg Phe 
            20                  25                  30          


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
        35                  40                  45              


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
    50                  55                  60                  


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Val 
65                  70                  75                  80  


Arg Asp Tyr Ile Arg Ala Ala Glu Trp Tyr Ser Asn Pro Leu Ser Ala 
                85                  90                  95      


Ile Phe Thr Thr Gly Gly His His His His His His Gly Gly Gly Leu 
            100                 105                 110         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        115                 120                 125 


<210>  1157
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Luk32_HIS_SA

<400>  1157

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Tyr His Glu Asn Ala Tyr Leu Leu Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Tyr Asp 
65                  70                  75                  80  


Leu Thr Pro Glu Lys Arg Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr Gly Gly His His His His His His Gly Gly Gly Leu Asn Asp Ile 
            100                 105                 110         


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        115                 120         


<210>  1158
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Luk163_HIS_SA

<400>  1158

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Tyr Ile Glu Tyr Trp Glu Pro Thr Ser Asp Gly Glu Ala Ile Ala Leu 
        35                  40                  45              


Asn Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Phe Val Glu Ile Trp Gly Val Lys Gly Gly Pro Arg 
65                  70                  75                  80  


Ser Pro Pro Leu Ser Ala Trp Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            100                 105                 110         


Trp His Glu 
        115 


<210>  1159
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Luk174_HIS_SA

<400>  1159

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Asp Ile Glu Tyr Gly Glu Pro Glu Lys Ile Gly Glu Ala Ile Trp Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Trp Val Phe Ile Tyr Gly Val Lys Gly Gly Ala Leu 
65                  70                  75                  80  


Ser Arg Pro Leu Thr Ala Thr Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            100                 105                 110         


Trp His Glu 
        115 


<210>  1160
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Luk187_HIS_SA

<400>  1160

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Arg Ile Leu Tyr Phe Glu Tyr Lys Arg Leu Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Tyr Ile 
65                  70                  75                  80  


Ser Arg Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            100                 105                 110         


Trp His Glu 
        115 


<210>  1161
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Luk188_HIS_SA

<400>  1161

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile His Tyr Trp Glu Phe Asn Pro Ala Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Gly Ile 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            100                 105                 110         


Trp His Glu 
        115 


<210>  1162
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Luk311_HIS_SA

<400>  1162

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Trp Ile Ser Tyr Val Glu Pro Asp Asp Gly Glu Ala Ile Glu Leu Leu 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Ile Val Gln Ile Asp Gly Val Lys Gly Gly Thr Thr Ser 
65                  70                  75                  80  


Val Pro Leu Asn Ala Arg Phe Thr Thr Gly Gly His His His His His 
                85                  90                  95      


His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
            100                 105                 110         


His Glu 
        


<210>  1163
<211>  559
<212>  PRT
<213>  Artificial

<220>
<223>  HC431

<400>  1163

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Asn Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ser Thr Gly Tyr Lys Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Phe Thr Ala Asp Ala Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ile Ser Thr Ala Thr Asp Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  1164
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  LC431

<400>  1164

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Val Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  1165
<211>  559
<212>  PRT
<213>  Artificial

<220>
<223>  HC432

<400>  1165

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Gly Gly Gly Thr Tyr Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Arg Asp Gly Asn Tyr Gly Cys Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  1166
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  LC432

<400>  1166

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Val Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ser Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Pro Glu Asp Thr Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  1167
<211>  559
<212>  PRT
<213>  Artificial

<220>
<223>  HC505

<400>  1167

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Asn Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ser Thr Gly Tyr Lys Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn His Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Phe Thr Ala Asp Ala Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ile Ser Thr Ala Thr Asp Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  1168
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  LC505

<400>  1168

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Val Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  1169
<211>  559
<212>  PRT
<213>  Artificial

<220>
<223>  HC506

<400>  1169

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Gly Gly Gly Thr Tyr Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Arg Asp Gly Asn Tyr Gly Cys Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Ala Ala Leu Pro Ala Pro Ile Ala Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser 
465                 470                 475                 480 


Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala 
                485                 490                 495     


Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe Tyr Arg Gly 
            500                 505                 510         


Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu 
        515                 520                 525             


Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile Val Gly Val 
    530                 535                 540                 


Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr 
545                 550                 555                 


<210>  1170
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  LC506

<400>  1170

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Val Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ser Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Pro Glu Asp Thr Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  1171
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047001 (SAFN3-TENCON)

<400>  1171

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile 
    130                 135                 140                 


Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser Asn 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1172
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047002 (SABD-TENCON)

<400>  1172

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu 
            100                 105                 110         


Lys Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile 
    130                 135                 140                 


Tyr Gly Val Lys Gly Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1173
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047003 (TFFN3-TENCON)

<400>  1173

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile 
    130                 135                 140                 


Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser Asn 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1174
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047004 (SAFN3-LukE26)

<400>  1174

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile 
    130                 135                 140                 


Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1175
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047005 (SABD-LukE26)

<400>  1175

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu Tyr Ala Glu Pro Trp 
            100                 105                 110         


Val Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Val Val Phe Ile 
    130                 135                 140                 


Gly Gly Val Lys Gly Gly His Asn Ser Thr Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1176
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047006 (TFFN3-LukE26)

<400>  1176

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile 
    130                 135                 140                 


Glu Tyr Ala Glu Pro Trp Val Trp Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Val Val Phe Ile Gly Gly Val Lys Gly Gly His Asn Ser Thr 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1177
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  TENCON_HIS

<400>  1177

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg 
65                  70                  75                  80  


Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His 
        


<210>  1178
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047007

<400>  1178

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
    130                 135                 140                 


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1179
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047008

<400>  1179

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Thr Tyr Glu Glu Lys Phe 
            100                 105                 110         


Tyr Arg Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Lys Val Trp Ile 
    130                 135                 140                 


Val Gly Val Lys Gly Gly Gln Gly Ser Trp Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1180
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047009

<400>  1180

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
    130                 135                 140                 


Thr Tyr Glu Glu Lys Phe Tyr Arg Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Lys Val Trp Ile Val Gly Val Lys Gly Gly Gln Gly Ser Trp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1181
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047010

<400>  1181

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Tyr His Ala Ile His Arg Leu Asn His Phe Asp Ser 
    130                 135                 140                 


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
145                 150                 155                 160 


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Ala Gly Leu Lys 
                165                 170                 175     


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Pro Asp Ala 
            180                 185                 190         


Phe Val Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His 
        195                 200                 205             


His His His His His 
    210             


<210>  1182
<211>  175
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047011

<400>  1182

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Tyr His 
                85                  90                  95      


Ala Ile His Arg Leu Asn His Phe Asp Ser Phe Leu Ile Gln Tyr Gln 
            100                 105                 110         


Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
        115                 120                 125             


Glu Arg Ser Tyr Asp Leu Ala Gly Leu Lys Pro Gly Thr Glu Tyr Thr 
    130                 135                 140                 


Val Ser Ile Tyr Gly Val Leu Pro Asp Ala Phe Val Ser Ser Asn Pro 
145                 150                 155                 160 


Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
                165                 170                 175 


<210>  1183
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047012

<400>  1183

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Tyr His Ala Ile His Arg Leu Asn His Phe Asp Ser 
    130                 135                 140                 


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
145                 150                 155                 160 


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Ala Gly Leu Lys 
                165                 170                 175     


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Pro Asp Ala 
            180                 185                 190         


Phe Val Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His 
        195                 200                 205             


His His His His His 
    210             


<210>  1184
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047013

<400>  1184

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro Ile 
    130                 135                 140                 


Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser Tyr 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1185
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047014

<400>  1185

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Pro Ile Val Tyr Gln Glu Trp Gln 
            100                 105                 110         


Phe Tyr Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile 
    130                 135                 140                 


Tyr Gly Val Lys Gly Gly Ser Trp Ser Tyr Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1186
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047015

<400>  1186

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro Ile 
    130                 135                 140                 


Val Tyr Gln Glu Trp Gln Phe Tyr Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Leu Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser Tyr 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1187
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047016

<400>  1187

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Asn Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Asp Trp Asp Lys Tyr Tyr Thr Asn Arg Phe Asp Ser 
    130                 135                 140                 


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
145                 150                 155                 160 


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
                165                 170                 175     


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Val Arg Asp 
            180                 185                 190         


Tyr Ile Arg Ala Ala Glu Trp Tyr Ser Asn Pro Leu Ser Ala Ile Phe 
        195                 200                 205             


Thr Thr Gly Gly His His His His His His 
    210                 215             


<210>  1188
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047017

<400>  1188

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Asn Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Asp Trp 
                85                  90                  95      


Asp Lys Tyr Tyr Thr Asn Arg Phe Asp Ser Phe Leu Ile Gln Tyr Gln 
            100                 105                 110         


Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser 
        115                 120                 125             


Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr 
    130                 135                 140                 


Val Ser Ile Tyr Gly Val Leu Val Arg Asp Tyr Ile Arg Ala Ala Glu 
145                 150                 155                 160 


Trp Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His 
                165                 170                 175     


His His His His 
            180 


<210>  1189
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047018

<400>  1189

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Asn Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Asp Trp Asp Lys Tyr Tyr Thr Asn Arg Phe Asp Ser 
    130                 135                 140                 


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
145                 150                 155                 160 


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
                165                 170                 175     


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Leu Val Arg Asp 
            180                 185                 190         


Tyr Ile Arg Ala Ala Glu Trp Tyr Ser Asn Pro Leu Ser Ala Ile Phe 
        195                 200                 205             


Thr Thr Gly Gly His His His His His His 
    210                 215             


<210>  1190
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047019

<400>  1190

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Tyr His Glu Asn Ala Tyr Leu Leu Phe Asp Ser Phe 
    130                 135                 140                 


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
145                 150                 155                 160 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
                165                 170                 175     


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Tyr Asp Leu Thr 
            180                 185                 190         


Pro Glu Lys Arg Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly 
        195                 200                 205             


Gly His His His His His His 
    210                 215 


<210>  1191
<211>  177
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047020

<400>  1191

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Tyr His 
                85                  90                  95      


Glu Asn Ala Tyr Leu Leu Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu 
            100                 105                 110         


Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu 
        115                 120                 125             


Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val 
    130                 135                 140                 


Ser Ile Tyr Gly Val Val Tyr Asp Leu Thr Pro Glu Lys Arg Ser Ser 
145                 150                 155                 160 


Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His 
                165                 170                 175     


His 
    


<210>  1192
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047021

<400>  1192

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Tyr His Glu Asn Ala Tyr Leu Leu Phe Asp Ser Phe 
    130                 135                 140                 


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
145                 150                 155                 160 


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
                165                 170                 175     


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Tyr Asp Leu Thr 
            180                 185                 190         


Pro Glu Lys Arg Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly 
        195                 200                 205             


Gly His His His His His His 
    210                 215 


<210>  1193
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047022

<400>  1193

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile 
    130                 135                 140                 


Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly Trp 
            180                 185                 190         


Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly 
        195                 200                 205             


Gly His His His His His His 
    210                 215 


<210>  1194
<211>  177
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047023

<400>  1194

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu 
            100                 105                 110         


Lys Val Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile 
    130                 135                 140                 


Tyr Gly Val Glu Leu Ile Tyr His Gly Trp Leu Asp Phe Val Phe Ser 
145                 150                 155                 160 


Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His 
                165                 170                 175     


His 
    


<210>  1195
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047024

<400>  1195

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile 
    130                 135                 140                 


Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Thr Val Ser Ile Tyr Gly Val Glu Leu Ile Tyr His Gly Trp 
            180                 185                 190         


Leu Asp Phe Val Phe Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly 
        195                 200                 205             


Gly His His His His His His 
    210                 215 


<210>  1196
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047025

<400>  1196

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr Ile 
    130                 135                 140                 


Glu Tyr Trp Glu Pro Thr Ser Asp Gly Glu Ala Ile Ala Leu Asn Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Glu Ile Trp Gly Val Lys Gly Gly Pro Arg Ser Pro 
            180                 185                 190         


Pro Leu Ser Ala Trp Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1197
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047026

<400>  1197

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Tyr Ile Glu Tyr Trp Glu Pro Thr 
            100                 105                 110         


Ser Asp Gly Glu Ala Ile Ala Leu Asn Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Glu Ile 
    130                 135                 140                 


Trp Gly Val Lys Gly Gly Pro Arg Ser Pro Pro Leu Ser Ala Trp Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1198
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047027

<400>  1198

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Tyr Ile 
    130                 135                 140                 


Glu Tyr Trp Glu Pro Thr Ser Asp Gly Glu Ala Ile Ala Leu Asn Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Glu Ile Trp Gly Val Lys Gly Gly Pro Arg Ser Pro 
            180                 185                 190         


Pro Leu Ser Ala Trp Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1199
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047028

<400>  1199

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp Ile 
    130                 135                 140                 


Glu Tyr Gly Glu Pro Glu Lys Ile Gly Glu Ala Ile Trp Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Trp Val Phe Ile Tyr Gly Val Lys Gly Gly Ala Leu Ser Arg 
            180                 185                 190         


Pro Leu Thr Ala Thr Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1200
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047029

<400>  1200

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Asp Ile Glu Tyr Gly Glu Pro Glu 
            100                 105                 110         


Lys Ile Gly Glu Ala Ile Trp Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Trp Val Phe Ile 
    130                 135                 140                 


Tyr Gly Val Lys Gly Gly Ala Leu Ser Arg Pro Leu Thr Ala Thr Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1201
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047030

<400>  1201

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp Ile 
    130                 135                 140                 


Glu Tyr Gly Glu Pro Glu Lys Ile Gly Glu Ala Ile Trp Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Trp Val Phe Ile Tyr Gly Val Lys Gly Gly Ala Leu Ser Arg 
            180                 185                 190         


Pro Leu Thr Ala Thr Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1202
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047031

<400>  1202

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg Ile 
    130                 135                 140                 


Leu Tyr Phe Glu Tyr Lys Arg Leu Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Tyr Ile Ser Arg 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1203
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047032

<400>  1203

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Arg Ile Leu Tyr Phe Glu Tyr Lys 
            100                 105                 110         


Arg Leu Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Gly Ile 
    130                 135                 140                 


His Gly Val Lys Gly Gly Tyr Ile Ser Arg Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1204
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047033

<400>  1204

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Arg Ile 
    130                 135                 140                 


Leu Tyr Phe Glu Tyr Lys Arg Leu Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Tyr Ile Ser Arg 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1205
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047034

<400>  1205

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile 
    130                 135                 140                 


His Tyr Trp Glu Phe Asn Pro Ala Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Gly Ile Ser Trp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1206
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047035

<400>  1206

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe His Ile His Tyr Trp Glu Phe Asn 
            100                 105                 110         


Pro Ala Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Gly Ile 
    130                 135                 140                 


His Gly Val Lys Gly Gly Gly Ile Ser Trp Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1207
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047036

<400>  1207

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile 
    130                 135                 140                 


His Tyr Trp Glu Phe Asn Pro Ala Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Gly Ile His Gly Val Lys Gly Gly Gly Ile Ser Trp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1208
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047037

<400>  1208

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile 
    130                 135                 140                 


Phe Tyr His Glu Thr Asp Ala Tyr Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Ile Ser Ser 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1209
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047038

<400>  1209

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe His Ile Phe Tyr His Glu Thr Asp 
            100                 105                 110         


Ala Tyr Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Val Ile 
    130                 135                 140                 


His Gly Val Lys Gly Gly Phe Ile Ser Ser Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1210
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047039

<400>  1210

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile 
    130                 135                 140                 


Phe Tyr His Glu Thr Asp Ala Tyr Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Phe Ile Ser Ser 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1211
<211>  207
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047040

<400>  1211

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
    130                 135                 140                 


Ser Tyr Val Glu Pro Asp Asp Gly Glu Ala Ile Glu Leu Leu Val Pro 
145                 150                 155                 160 


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
                165                 170                 175     


Tyr Ile Val Gln Ile Asp Gly Val Lys Gly Gly Thr Thr Ser Val Pro 
            180                 185                 190         


Leu Asn Ala Arg Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205         


<210>  1212
<211>  169
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047041

<400>  1212

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile Ser Tyr Val Glu Pro Asp 
            100                 105                 110         


Asp Gly Glu Ala Ile Glu Leu Leu Val Pro Gly Ser Glu Arg Ser Tyr 
        115                 120                 125             


Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Ile Val Gln Ile Asp 
    130                 135                 140                 


Gly Val Lys Gly Gly Thr Thr Ser Val Pro Leu Asn Ala Arg Phe Thr 
145                 150                 155                 160 


Thr Gly Gly His His His His His His 
                165                 


<210>  1213
<211>  207
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047042

<400>  1213

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Trp Ile 
    130                 135                 140                 


Ser Tyr Val Glu Pro Asp Asp Gly Glu Ala Ile Glu Leu Leu Val Pro 
145                 150                 155                 160 


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
                165                 170                 175     


Tyr Ile Val Gln Ile Asp Gly Val Lys Gly Gly Thr Thr Ser Val Pro 
            180                 185                 190         


Leu Asn Ala Arg Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205         


<210>  1214
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047043

<400>  1214

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly Ile 
    130                 135                 140                 


Gly Tyr Leu Glu Tyr Pro Trp Tyr Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Asp Ile Tyr Gly Val Lys Gly Gly Trp Trp Ser Tyr 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1215
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047044

<400>  1215

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Gly Ile Gly Tyr Leu Glu Tyr Pro 
            100                 105                 110         


Trp Tyr Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Asp Ile 
    130                 135                 140                 


Tyr Gly Val Lys Gly Gly Trp Trp Ser Tyr Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1216
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047045

<400>  1216

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gly Ile 
    130                 135                 140                 


Gly Tyr Leu Glu Tyr Pro Trp Tyr Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Asp Ile Tyr Gly Val Lys Gly Gly Trp Trp Ser Tyr 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1217
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047046

<400>  1217

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn Ile 
    130                 135                 140                 


Asp Tyr Phe Glu Tyr Tyr Glu Phe Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser Leu 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1218
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047047

<400>  1218

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Asn Ile Asp Tyr Phe Glu Tyr Tyr 
            100                 105                 110         


Glu Phe Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Asp Ile 
    130                 135                 140                 


Tyr Gly Val Lys Gly Gly Ser Trp Ser Leu Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1219
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047048

<400>  1219

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn Ile 
    130                 135                 140                 


Asp Tyr Phe Glu Tyr Tyr Glu Phe Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Asp Ile Tyr Gly Val Lys Gly Gly Ser Trp Ser Leu 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1220
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047049

<400>  1220

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp Ile 
    130                 135                 140                 


Ser Tyr Asp Glu Tyr Pro Glu Phe Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Leu Val Asp Ile Ile Gly Val Lys Gly Gly Glu Ile Ser Leu 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1221
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047050

<400>  1221

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Asp Ile Ser Tyr Asp Glu Tyr Pro 
            100                 105                 110         


Glu Phe Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Asp Ile 
    130                 135                 140                 


Ile Gly Val Lys Gly Gly Glu Ile Ser Leu Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1222
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047051

<400>  1222

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asp Ile 
    130                 135                 140                 


Ser Tyr Asp Glu Tyr Pro Glu Phe Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Leu Val Asp Ile Ile Gly Val Lys Gly Gly Glu Ile Ser Leu 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1223
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047052

<400>  1223

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn Ile 
    130                 135                 140                 


His Tyr Ala Glu Tyr Pro Asp Phe Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Ile Val Asp Ile Trp Gly Val Lys Gly Gly Leu Gly Ser Trp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1224
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047053

<400>  1224

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Asn Ile His Tyr Ala Glu Tyr Pro 
            100                 105                 110         


Asp Phe Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Ile Val Asp Ile 
    130                 135                 140                 


Trp Gly Val Lys Gly Gly Leu Gly Ser Trp Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1225
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047054

<400>  1225

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Asn Ile 
    130                 135                 140                 


His Tyr Ala Glu Tyr Pro Asp Phe Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Ile Val Asp Ile Trp Gly Val Lys Gly Gly Leu Gly Ser Trp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1226
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047055

<400>  1226

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val Ile 
    130                 135                 140                 


Phe Tyr Gly Glu Tyr Glu Asn Gly Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Ile Ile Val Gly Val Lys Gly Gly Phe Asp Ser Lys 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1227
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047056

<400>  1227

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Val Ile Phe Tyr Gly Glu Tyr Glu 
            100                 105                 110         


Asn Gly Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Ile Ile 
    130                 135                 140                 


Val Gly Val Lys Gly Gly Phe Asp Ser Lys Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1228
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047057

<400>  1228

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val Ile 
    130                 135                 140                 


Phe Tyr Gly Glu Tyr Glu Asn Gly Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Ile Ile Val Gly Val Lys Gly Gly Phe Asp Ser Lys 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1229
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047058

<400>  1229

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln Ile 
    130                 135                 140                 


Phe Tyr Gln Glu Val Val Glu Trp Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Trp Ile Ser Asp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1230
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047059

<400>  1230

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Gln Ile Phe Tyr Gln Glu Val Val 
            100                 105                 110         


Glu Trp Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Val Ile 
    130                 135                 140                 


His Gly Val Lys Gly Gly Trp Ile Ser Asp Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1231
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047060

<400>  1231

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Gln Ile 
    130                 135                 140                 


Phe Tyr Gln Glu Val Val Glu Trp Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Trp Ile Ser Asp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1232
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047061

<400>  1232

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala Ile 
    130                 135                 140                 


Phe Tyr Val Glu Leu Val Trp Lys Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser Asp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1233
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047062

<400>  1233

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Ala Ile Phe Tyr Val Glu Leu Val 
            100                 105                 110         


Trp Lys Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Phe Val Val Ile 
    130                 135                 140                 


His Gly Val Lys Gly Gly Tyr Ile Ser Asp Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1234
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047063

<400>  1234

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala Ile 
    130                 135                 140                 


Phe Tyr Val Glu Leu Val Trp Lys Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Phe Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser Asp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1235
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047064

<400>  1235

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val Ile 
    130                 135                 140                 


Phe Tyr His Glu Thr Arg Val Thr Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser Glu 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1236
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047065

<400>  1236

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Val Ile Phe Tyr His Glu Thr Arg 
            100                 105                 110         


Val Thr Gly Glu Ala Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Leu Val Val Ile 
    130                 135                 140                 


His Gly Val Lys Gly Gly Tyr Ile Ser Glu Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1237
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047066

<400>  1237

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Val Ile 
    130                 135                 140                 


Phe Tyr His Glu Thr Arg Val Thr Gly Glu Ala Ile Val Leu Thr Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Leu Val Val Ile His Gly Val Lys Gly Gly Tyr Ile Ser Glu 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1238
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047067

<400>  1238

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


His Ile Glu Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile 
    130                 135                 140                 


Asp Tyr Trp Glu Gly Glu Phe Asp Gly Glu Ala Ile His Leu Phe Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Asp Val Phe Ile Val Gly Val Lys Gly Gly His Gly Ser Asp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1239
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047068

<400>  1239

Met Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile 
1               5                   10                  15      


Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu 
            20                  25                  30          


Ile Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu 
        35                  40                  45              


Ile Leu Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Pro Ala Pro Lys Asn Leu 
65                  70                  75                  80  


Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala 
                85                  90                  95      


Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile Asp Tyr Trp Glu Gly Glu 
            100                 105                 110         


Phe Asp Gly Glu Ala Ile His Leu Phe Val Pro Gly Ser Glu Arg Ser 
        115                 120                 125             


Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu Tyr Asp Val Phe Ile 
    130                 135                 140                 


Val Gly Val Lys Gly Gly His Gly Ser Asp Pro Leu Ser Ala Ile Phe 
145                 150                 155                 160 


Thr Thr Gly Gly His His His His His His 
                165                 170 


<210>  1240
<211>  208
<212>  PRT
<213>  Artificial

<220>
<223>  Luk047069

<400>  1240

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Glu Tyr Glu Glu Leu Arg Asp Trp Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ser Val Ser Ile Thr Gly Val Lys Gly Gly Ala Glu 
65                  70                  75                  80  


Ser Trp Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu 
            100                 105                 110         


Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala 
        115                 120                 125             


Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu Ile 
    130                 135                 140                 


Asp Tyr Trp Glu Gly Glu Phe Asp Gly Glu Ala Ile His Leu Phe Val 
145                 150                 155                 160 


Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr 
                165                 170                 175     


Glu Tyr Asp Val Phe Ile Val Gly Val Lys Gly Gly His Gly Ser Asp 
            180                 185                 190         


Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His His His 
        195                 200                 205             


<210>  1241
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  TENCON parent

<400>  1241

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  1242
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  1242

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Arg Phe Ser Phe Arg Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Gln Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala Thr Ser Tyr Tyr Trp Val His Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1243
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1243

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


