                               SEQUENCE LISTING

<110> TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER 
      EDUCATION
 
<120> METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV 
      INFECTION

<130> 4941I.016

<140> PCT/US2016/035141
<141> 2016-06-01

<150> 62/308,320
<151> 2016-03-15

<150> 62/169,633
<151> 2015-06-02

<150> 62/169,384
<151> 2015-06-01

<160> 90    

<170> PatentIn version 3.5

<210> 1
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 1
aaacagggcc agggatcaga tatccactga ccttgt                                 36


<210> 2
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
taaacaaggt cagtggatat ctgatccctg gccct                                  35


<210> 3
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 3
aaacagctcg atgtcagcag ttcttgaagt actcgt                                 36


<210> 4
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
taaacgagta cttcaagaac tgctgacatc gagct                                  35


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
caccgattgg cagaactaca cacc                                              24


<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
aaacggtgtg tagttctgcc aatc                                              24


<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
caccgcgtgg cctgggcggg actg                                              24


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
aaaccagtcc cgcccaggcc acgc                                              24


<210> 9
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
caccgatctg tggatctacc acacaca                                           27


<210> 10
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
aaactgtgtg tggtagatcc acagatc                                           27


<210> 11
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
caccgctgct tatatgcagc atctgag                                           27


<210> 12
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
aaacctcaga tgctgcatat aagcagc                                           27


<210> 13
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
caccgtgtgg tagatccaca gatca                                             25


<210> 14
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
aaactgatct gtggatctac cacac                                             25


<210> 15
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
caccgcaggg aagtagcctt gtgtg                                             25


<210> 16
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
aaaccacaca aggctacttc cctgc                                             25


<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
caccgatcag atatccactg acctt                                             25


<210> 18
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
aaacaaggtc agtggatatc tgatc                                             25


<210> 19
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
caccgcacac taatacttct ccctc                                             25


<210> 20
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
aaacgaggga gaagtattag tgtgc                                             25


<210> 21
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
caccgcctcc tagcatttcg tcaca                                             25


<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
aaactgtgac gaaatgctag gaggc                                             25


<210> 23
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
caccgcatgg cccgagagct gcatc                                             25


<210> 24
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
aaacgatgca gctctcgggc catgc                                             25


<210> 25
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
caccgcagca gtctttgtag tactc                                             25


<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
aaacgagtac tacaaagact gctgc                                             25


<210> 27
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
caccgctgac atcgagcttt ctaca                                             25


<210> 28
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
aaactgtaga aagctcgatg tcagc                                             25


<210> 29
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
caccgtctac aagggacttt ccgct                                             25


<210> 30
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
aaacagcgga aagtcccttg tagac                                             25


<210> 31
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
caccgctttc cgctggggac tttcc                                             25


<210> 32
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
aaacggaaag tccccagcgg aaagc                                             25


<210> 33
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
caccgcctcc ctggaaagtc cccag                                             25


<210> 34
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
aaacctgggg actttccagg gaggc                                             25


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
caccgcctgg gcgggactgg ggag                                              24


<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
aaacctcccc agtcccgccc aggc                                              24


<210> 37
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
caccgtccat cccatgcagg ctcac                                             25


<210> 38
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
aaacgtgagc ctgcatggga tggac                                             25


<210> 39
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
caccgcggag agagaagtat tagag                                             25


<210> 40
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
aaacctctaa tacttctctc tccgc                                             25


<210> 41
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
caccggccag atgagagaac caag                                              24


<210> 42
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
aaaccttggt tctctcatct ggcc                                              24


<210> 43
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
caccgccttc ccacaaggga aggcca                                            26


<210> 44
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
aaactggcct tcccttgtgg gaaggc                                            26


<210> 45
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
caccgcgaga gcgtcggtat taagcg                                            26


<210> 46
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
aaaccgctta ataccgacgc tctcgc                                            26


<210> 47
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
caccggatag atgtaaaaga cacca                                             25


<210> 48
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
aaactggtgt cttttacatc tatcc                                             25


<210> 49
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
caccgcagga tatgtaactg acag                                              24


<210> 50
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
aaacctgtca gttacatatc ctgc                                              24


<210> 51
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
caccgcatgg gtaccagcac acaa                                              24


<210> 52
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
aaacttgtgt gctggtaccc atgc                                              24


<210> 53
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
caccgcttta ttgaggctta agcag                                             25


<210> 54
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
aaacgagtca cacaacagac gggc                                              24


<210> 55
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
tggaatgcag tggcgcgatc ttggc                                             25


<210> 56
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
cacagcatca agaagaacct gat                                               23


<210> 57
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
tgaagatctc ttgcagatag cag                                               23


<210> 58
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
gatctgtgga tctaccacac aca                                               23


<210> 59
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
cccactgtgt ttagcatggt att                                               23


<210> 60
<211> 101
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 60
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaaag uggcaccga gucggugcuuu u                          101


<210> 61
<211> 400
<212> DNA
<213> Human immunodeficiency virus 1

<400> 61
tccttgatct gtggatctac cacacacaag gctacttccc tgattggcag aactacacac       60

cagggccagg gatcagatat ccactgacct ttggatggtg cttcaagtta gtaccagttg      120

aaccagagca agtagaagag gccaatgaag gagagaacaa cagcttgtta caccctatga      180

gccagcatgg gatggaggac ccggagggag aagtattagt gtggaagttt gacagcctcc      240

tagcatttcg tcacatggcc cgagagctgc atccggagta ctacaaagac tgctgacatc      300

gagctttcta caagggactt tccgctgggg actttccagg gaggtgtggc ctgggcggga      360

ctggggagtg gcgagccctc agatgctaca tataagcagc                            400


<210> 62
<211> 26
<212> DNA
<213> Human immunodeficiency virus 1

<400> 62
gagggctcgc cactccccag agctgc                                            26


<210> 63
<211> 25
<212> DNA
<213> Human immunodeficiency virus 1

<400> 63
cgctcccctg gtgtgtagtt ctgcc                                             25


<210> 64
<211> 46
<212> DNA
<213> Human immunodeficiency virus 1

<400> 64
agggctcgcc actccccagc ctggtgtgta gttctgccaa tcaggg                      46


<210> 65
<211> 633
<212> DNA
<213> Human immunodeficiency virus 1

<400> 65
tggaagggct aatttggtcc caaaaaagac aagagatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tggcagaact acacaccagg gccagggatc agatatccac      120

tgacctttgg atggtgcttc aagttagtac cagttgaacc agagcaagta gaagaggcca      180

aataaggaga gaagaacagc ttgttacacc ctatgagcca gcatgggatg gaggacccgg      240

agggagaagt attagtgtgg aagtttgaca gcctcctagc atttcgtcac atggcccgag      300

agctgcatcc ggagtactac aaagactgct gacatcgagc tttctacaag ggactttccg      360

ctggggactt tccagggagg tgtggcctgg gcgggactgg ggagtggcga gccctcagat      420

gctacatata agcagctgct ttttgcctgt actgggtctc tctggttaga ccagatctga      480

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct      540

tgagtgctca aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc      600

aaccctttta gtcagtgtgg aaaatctcta gca                                   633


<210> 66
<211> 49
<212> DNA
<213> Human immunodeficiency virus 1

<400> 66
gccgagagct gcatccggag ctaagtttta cttcaagaac tgctgacat                   49


<210> 67
<211> 23
<212> DNA
<213> Human immunodeficiency virus 1

<400> 67
atcagatatc cactgacctt tgg                                               23


<210> 68
<211> 23
<212> DNA
<213> Human immunodeficiency virus 1

<400> 68
cagcagttcg aagtactccc cgg                                               23


<210> 69
<211> 15
<212> DNA
<213> Human immunodeficiency virus 1

<400> 69
tccactgacc tttgg                                                        15


<210> 70
<211> 16
<212> DNA
<213> Human immunodeficiency virus 1

<400> 70
atccactgac ctttgg                                                       16


<210> 71
<211> 24
<212> DNA
<213> Human immunodeficiency virus 1

<400> 71
gcgtttacgt gtgtgccaag tgtg                                              24


<210> 72
<211> 30
<212> DNA
<213> Human immunodeficiency virus 1

<400> 72
gctatgagct gttctccagc cgctcgaagt                                        30


<210> 73
<211> 78
<212> DNA
<213> Human immunodeficiency virus 1

<400> 73
ctggggactt tccagggagg tgtggcctgg gcgggactgg ggggccagat gagagaacca       60

aggggaagtg acatagca                                                     78


<210> 74
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
ctggggactt tccagggagg cgtggcctgg gcgggacaag gggaagtgac atagca           56


<210> 75
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
ctggggactt tccagggagg cgtggcctgg gcgggacaag ggtaagtgac atagca           56


<210> 76
<211> 65
<212> DNA
<213> Human immunodeficiency virus 1

<400> 76
acgtggcccg agagctgcat ccggggatag atgtaaaaga caccaaggaa gccttagata       60

agata                                                                   65


<210> 77
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
acgtggcccg agagctgcac caaggaagcc ttagataaga ta                          42


<210> 78
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
acatggcccg agagctgccc aaggaagcct tagataagat a                           41


<210> 79
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
acgtggccag agagctgcca aggaagcctt agataagata                             40


<210> 80
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
acatggcccg agagctgcac caaggaagcc ttagataaga ta                          42


<210> 81
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 81
acgtggcccg agagctgcag gtgtgccacc atgcccagct agtttttgta ttttaccaag       60

gaagccttag aaaagata                                                     78


<210> 82
<211> 233
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 82
acatggcccg agagctgcca ggccggtgat gctctggtgg atcagggtgg cgtccagcac       60

ctctttggtg ctggtgtacc tcttccggtc gatggtggtg tcaaagtact tgaaggcggc      120

aggggctccc agattggtca gggtaaacag gtggatgata ttctcggcct gctctctgat      180

gggcttatcc cggtgcttgt tgtaggcgga ccaaggaagc cttagataag ata             233


<210> 83
<211> 328
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 83
acgtggcccg agagctgcat ccggactgta ctgagtctct ctggttagac cagatctgag       60

cctgggagct ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt      120

gagtgcttca agtagtgtgt gcccgtctgt tgtgtgattc tggtaactag agatccctca      180

gaccctttta gtcagtgtgg aaaatctcta gcagggcccg tttaaacccg ctgatcagcc      240

tcgactgtgc cttctagtta ccagccatct gttgtttgcc cctcccccgt gccttccttg      300

accctgcaag gaagccttag ataagata                                         328


<210> 84
<211> 86
<212> DNA
<213> Human immunodeficiency virus 1

<400> 84
agctgcatcc ggagtactac aaagactgct gacatcgagc tttctggata gatgtaaaag       60

acaccaagga agccttagat aagata                                            86


<210> 85
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
agctgcatcc ggagtactac aaagactgct gacatcgagc tttctaccaa ggaagcctta       60

gataagata                                                               69


<210> 86
<211> 67
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
agctgcatcc ggagtactac aaagactgct gacatcgagc tttaccaagg aagccttaga       60

taagata                                                                 67


<210> 87
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
agctgcatcc ggagtactac aaagactgct gacatcgagc tttctcacca aggaagcctt       60

agataagata                                                              70


<210> 88
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
agctgcatcc ggagtactac aaagactgct gacatcgagc tttctccaag gaagccttag       60

ataagata                                                                68


<210> 89
<211> 398
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 89
agctgcatcc ggagctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc       60

tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa      120

gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag      180

tcagtgtgga aaatctctag cagagcccgt ttaaacccgc tgatcagcct cgactgtgcc      240

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg      300

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag      360

gtgtcattct attcaccaag gaagccttag ataagata                              398


<210> 90
<211> 225
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 90
agctgcatcc ggagcactac aaagactgct gacatcgagc ttcactacaa agactgctga       60

catcgagctt taattcactc ccaaagaagt caagatctgc tttttgcctg tactgggtct      120

ctctggttag accagagtct ctctggttag accagatctg agcctgggag ctctctggct      180

aactagggaa cccactgctt aaccaaggaa gccttagata agata                      225


