                               SEQUENCE LISTING

<110> MOLECULAR TEMPLATES, INC.
 
<120> DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT SCAFFOLDS AND CELL-TARGETING 
      MOLECULES COMPRISING THE SAME

<130> 15-02PCT

<140> PCT/US2016/034778
<141> 2016-05-27

<150> 62/168,758
<151> 2015-05-30

<150> 62/168,759
<151> 2015-05-30

<150> 62/168,760
<151> 2015-05-30

<150> 62/168,761
<151> 2015-05-30

<150> 62/168,762
<151> 2015-05-30

<150> 62/168,763
<151> 2015-05-30

<160> 594   

<170> PatentIn version 3.5

<210> 1
<211> 293
<212> PRT
<213> Escherichia coli

<400> 1
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210> 2
<211> 293
<212> PRT
<213> Shigella dysenteriae

<400> 2
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210> 3
<211> 297
<212> PRT
<213> Escherichia coli

<400> 3
Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Leu Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg Ser Val Ser Gln Lys Gln 
                245                 250                 255     


Lys Thr Glu Cys Gln Ile Val Gly Asp Arg Ala Ala Ile Lys Val Asn 
            260                 265                 270         


Asn Val Leu Trp Glu Ala Asn Thr Ile Ala Ala Leu Leu Asn Arg Lys 
        275                 280                 285             


Pro Gln Asp Leu Thr Glu Pro Asn Gln 
    290                 295         


<210> 4
<211> 251
<212> PRT
<213> Shigella dysenteriae

<400> 4
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 5
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 6
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr Val 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 7
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 8
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 9
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 10
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 11
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 12
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 13
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 14
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 15
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 16
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 17
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 18
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 19
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 20
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 21
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 22
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 23
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Ala Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 24
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Ala Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 25
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Ile Glu Ala Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Ala Ala Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 26
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Ala Val Ala Ala 
            260         


<210> 27
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 28
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 29
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 30
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 31
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 32
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 33
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Met Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ser Gly Asp Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro 
305                 310                 315                 320 


Glu Glu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Gly Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210> 34
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 35
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln 
            420                 425                 430         


Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly 
        435                 440                 445             


Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys 
    450                 455                 460                 


Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala 
465                 470                 475                 480 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly 
                485                 490                 495     


Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510         


Ala 
    


<210> 36
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
305                 310                 315                 320 


Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                405                 410                 415     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            420                 425                 430         


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        435                 440                 445             


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    450                 455                 460                 


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
465                 470                 475                 480 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Leu Val Thr Val Ser Ser Ala 
        515                 520     


<210> 37
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
385                 390                 395                 400 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His 
            420                 425                 430         


Ala Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val 
        435                 440                 445             


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
    450                 455                 460                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg 
465                 470                 475                 480 


Ile Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 38
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 39
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu 
            260                 265                 270         


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
        275                 280                 285             


Ile Ser Cys Arg Ala Thr Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
    290                 295                 300                 


Val Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
305                 310                 315                 320 


Tyr Ala Ala Ser Ser Val Asp Ser Gly Val Pro Ala Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile His Pro Val Glu Glu 
            340                 345                 350         


Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Arg Val Pro Tyr 
        355                 360                 365             


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                405                 410                 415     


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
            420                 425                 430         


Gly Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr Asn Glu Met Phe 
        435                 440                 445             


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Gln Ala Trp Gly Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ala 
            


<210> 40
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser 
305                 310                 315                 320 


Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Ala Phe Ser Ile Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu 
            420                 425                 430         


Lys Cys Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr 
        435                 440                 445             


Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
465                 470                 475                 480 


Thr Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr Gly Thr His Trp 
                485                 490                 495     


Gly Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ala 
    


<210> 41
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Glu Leu 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Phe Ser Val Ser Leu Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Lys Val Gln Leu Gln Glu Ser Gly Pro Ser Leu 
385                 390                 395                 400 


Val Gln Pro Ser Gln Arg Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
                405                 410                 415     


Ser Leu Ile Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Trp Leu Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr 
        435                 440                 445             


Asn Ala Ala Phe Met Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys 
    450                 455                 460                 


Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala 
465                 470                 475                 480 


Ile Tyr Phe Cys Ala Lys Thr Leu Ile Thr Thr Gly Tyr Ala Met Asp 
                485                 490                 495     


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505             


<210> 42
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Glu Leu 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Phe Ser Val Ser Leu Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Lys Val Gln Leu Gln Glu Ser Gly Pro Ser Leu 
385                 390                 395                 400 


Val Gln Pro Ser Gln Arg Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
                405                 410                 415     


Ser Leu Ile Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys 
            420                 425                 430         


Gly Leu Glu Trp Leu Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr 
        435                 440                 445             


Asn Ala Ala Phe Met Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys 
    450                 455                 460                 


Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala 
465                 470                 475                 480 


Ile Tyr Phe Cys Ala Lys Thr Leu Ile Thr Thr Gly Tyr Ala Met Asp 
                485                 490                 495     


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505             


<210> 43
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 44
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 45
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 46
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 47
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 48
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 49
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Met Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 50
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 51
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Met Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 52
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 52
Met Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 53
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Met Ala Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 54
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Met Ala Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 55
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Met Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Ile Glu Ala Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Ala Ala Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 56
<211> 510
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr 
                245                 250                 255     


Val Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro Ser Thr Pro Pro 
            260                 265                 270         


Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr Gln Ser Pro Ser 
        275                 280                 285             


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
    290                 295                 300                 


Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln Gln Lys Pro Gly 
305                 310                 315                 320 


Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly 
                325                 330                 335     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
            340                 345                 350         


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
        355                 360                 365             


Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
    370                 375                 380                 


Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
385                 390                 395                 400 


Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                405                 410                 415     


Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro 
            420                 425                 430         


Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser Thr 
        435                 440                 445             


Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp Asn 
    450                 455                 460                 


Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe Val 
                485                 490                 495     


Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510 


<210> 57
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr 
            100                 105                 110         


Val Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln 
            420                 425                 430         


Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly 
        435                 440                 445             


Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys 
    450                 455                 460                 


Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala 
465                 470                 475                 480 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly 
                485                 490                 495     


Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510         


Ala 
    


<210> 58
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 58
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln 
            420                 425                 430         


Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly 
        435                 440                 445             


Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys 
    450                 455                 460                 


Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala 
465                 470                 475                 480 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly 
                485                 490                 495     


Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510         


<210> 59
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 59
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln 
            420                 425                 430         


Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly 
        435                 440                 445             


Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys 
    450                 455                 460                 


Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala 
465                 470                 475                 480 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly 
                485                 490                 495     


Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510         


Ala 
    


<210> 60
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met 
        35                  40                  45              


Val Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln 
            420                 425                 430         


Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly 
        435                 440                 445             


Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys 
    450                 455                 460                 


Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala 
465                 470                 475                 480 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly 
                485                 490                 495     


Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510         


Ala 
    


<210> 61
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln 
            420                 425                 430         


Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly 
        435                 440                 445             


Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys 
    450                 455                 460                 


Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala 
465                 470                 475                 480 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly 
                485                 490                 495     


Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510         


Ala 
    


<210> 62
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 62
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln 
            420                 425                 430         


Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly 
        435                 440                 445             


Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys 
    450                 455                 460                 


Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala 
465                 470                 475                 480 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly 
                485                 490                 495     


Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510         


<210> 63
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 63
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser 
385                 390                 395                 400 


Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
                405                 410                 415     


Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln 
            420                 425                 430         


Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly 
        435                 440                 445             


Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys 
    450                 455                 460                 


Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala 
465                 470                 475                 480 


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly 
                485                 490                 495     


Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510         


Ala 
    


<210> 64
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 64
Met Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ile Gly Asp Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe 
305                 310                 315                 320 


Thr Leu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210> 65
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 65
Met Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser 
    130                 135                 140                 


Gln Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser 
                245                 250                 255     


Ser Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys 
            260                 265                 270         


Thr Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro 
        275                 280                 285             


Leu Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser 
    290                 295                 300                 


Gly Ile Gly Asp Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe 
305                 310                 315                 320 


Thr Leu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn 
                325                 330                 335     


Leu Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg 
            340                 345                 350         


Phe Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr 
        355                 360                 365             


Leu Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile 
    370                 375                 380                 


Ser Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr 
385                 390                 395                 400 


Leu Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala 
                405                 410                 415     


Arg Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe 
            420                 425                 430         


Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly 
        435                 440                 445             


Ala Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp 
    450                 455                 460                 


Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val 
465                 470                 475                 480 


Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser 
                485                 490                 495     


Val Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510         


<210> 66
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
305                 310                 315                 320 


Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                405                 410                 415     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            420                 425                 430         


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        435                 440                 445             


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    450                 455                 460                 


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
465                 470                 475                 480 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Leu Val Thr Val Ser Ser 
        515                 520 


<210> 67
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 67
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
305                 310                 315                 320 


Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                405                 410                 415     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            420                 425                 430         


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        435                 440                 445             


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    450                 455                 460                 


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
465                 470                 475                 480 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Leu Val Thr Val Ser Ser 
        515                 520 


<210> 68
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 68
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
385                 390                 395                 400 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His 
            420                 425                 430         


Ala Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val 
        435                 440                 445             


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
    450                 455                 460                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg 
465                 470                 475                 480 


Ile Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 69
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
385                 390                 395                 400 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His 
            420                 425                 430         


Ala Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val 
        435                 440                 445             


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
    450                 455                 460                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg 
465                 470                 475                 480 


Ile Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 70
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 70
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
385                 390                 395                 400 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His 
            420                 425                 430         


Ala Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val 
        435                 440                 445             


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
    450                 455                 460                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg 
465                 470                 475                 480 


Ile Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 71
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 71
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser 
305                 310                 315                 320 


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
385                 390                 395                 400 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp 
                405                 410                 415     


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His 
            420                 425                 430         


Ala Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val 
        435                 440                 445             


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
    450                 455                 460                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg 
465                 470                 475                 480 


Ile Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 72
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 72
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 73
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 73
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 74
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 74
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 75
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 75
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 76
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 76
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 77
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 77
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 78
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 78
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 79
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 79
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
305                 310                 315                 320 


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
        355                 360                 365             


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
                405                 410                 415     


Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
        435                 440                 445             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210> 80
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 80
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr 
            100                 105                 110         


Val Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser 
305                 310                 315                 320 


Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys 
        355                 360                 365             


Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    370                 375                 380                 


Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Phe Ala Phe Ser Ile Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu 
            420                 425                 430         


Lys Cys Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr 
        435                 440                 445             


Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
465                 470                 475                 480 


Thr Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr Gly Thr His Trp 
                485                 490                 495     


Gly Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            500                 505                 510         


Ala 
    


<210> 81
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 81
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu 
            260                 265                 270         


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr 
        275                 280                 285             


Ile Ser Cys Arg Ala Thr Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
    290                 295                 300                 


Val Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
305                 310                 315                 320 


Tyr Ala Ala Ser Ser Val Asp Ser Gly Val Pro Ala Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile His Pro Val Glu Glu 
            340                 345                 350         


Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Arg Val Pro Tyr 
        355                 360                 365             


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                405                 410                 415     


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
            420                 425                 430         


Gly Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr Asn Glu Met Phe 
        435                 440                 445             


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Gln Ala Trp Gly Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ala 
            


<210> 82
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 83
Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   


<210> 84
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 84
Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr 
1               5                   10                  


<210> 85
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 85
Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr 
1               5                   10              


<210> 86
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 86
Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10              


<210> 87
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 87
Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser 
1               5                   10      


<210> 88
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 88
Met Gln His Leu Glu Tyr Pro Phe 
1               5               


<210> 89
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 89
Tyr Ala Phe Ser Ser Tyr Trp Met Asn 
1               5                   


<210> 90
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 90
Trp Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr 
1               5                   10                  


<210> 91
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 91
Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210> 92
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 92
Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn 
1               5                   10          


<210> 93
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 93
Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser 
1               5                   10      


<210> 94
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 94
Gln Gln Ser Thr Glu Asp Pro Trp 
1               5               


<210> 95
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 95
Trp Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
1               5                   10                  15      


<210> 96
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 96
Gly Ser Ile Ser Thr Ser Gly Met Gly Val Gly 
1               5                   10      


<210> 97
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 97
Trp Ile Gly His Ile Trp Trp Asp Asp Asp Lys Arg Tyr 
1               5                   10              


<210> 98
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 98
Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210> 99
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 99
Ser Ser Val Ser Tyr Met His 
1               5           


<210> 100
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 100
Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210> 101
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 101
Phe Gln Gly Ser Val Tyr Pro Phe 
1               5               


<210> 102
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 102
Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210> 103
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 103
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 104
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 104
Ala Gln Leu Arg Pro Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210> 105
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 105
Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210> 106
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 106
Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210> 107
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 107
Gln Gln Trp Ile Ser Asn Pro Pro Thr 
1               5                   


<210> 108
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 108
Gly Tyr Thr Phe Thr Ser Tyr Asn Val His 
1               5                   10  


<210> 109
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 109
Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
1               5                   10                  


<210> 110
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 110
Arg Ala Ser Ser Ser Val Ser Tyr Met Asp 
1               5                   10  


<210> 111
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 111
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10          


<210> 112
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 112
Arg Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210> 113
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 113
Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210> 114
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 114
Gly Phe Thr Phe Asn Asp Tyr Ala Met His 
1               5                   10  


<210> 115
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 115
Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 116
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 116
Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210> 117
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 117
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210> 118
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 118
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 119
Gln Gln Arg Ser Asn Trp Pro Ile Thr 
1               5                   


<210> 120
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 120
Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210> 121
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 121
Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210> 122
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 122
Ala Pro Ser Asn Leu Ala Ser 
1               5           


<210> 123
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 123
Gln Gln Trp Ser Phe Asn Pro Pro Thr 
1               5                   


<210> 124
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 124
Gly Tyr Ala Phe Ser Tyr Ser Trp Ile Asn 
1               5                   10  


<210> 125
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 125
Arg Ile Phe Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 126
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 126
Asn Val Phe Asp Gly Tyr Trp Leu Val Tyr 
1               5                   10  


<210> 127
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 127
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210> 128
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 128
Gln Met Ser Asn Leu Val Ser 
1               5           


<210> 129
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 129
Ala Gln Asn Leu Glu Leu Pro Tyr Thr 
1               5                   


<210> 130
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 130
Tyr Arg Phe Thr Asn Tyr Trp Ile His 
1               5                   


<210> 131
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 131
Trp Ile Gly Gly Ile Asn Pro Gly Asn Asn Tyr Ala Thr Tyr Arg Arg 
1               5                   10                  15      


<210> 132
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 132
Thr Arg Glu Gly Tyr Gly Asn Tyr Gly Ala Trp Phe Ala Tyr 
1               5                   10                  


<210> 133
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 133
Gln Ser Leu Ala Asn Ser Tyr Gly Asn Thr Phe Leu Ser 
1               5                   10              


<210> 134
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 134
Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser 
1               5                   10      


<210> 135
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 135
Leu Gln Gly Thr His Gln Pro Tyr 
1               5               


<210> 136
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 136
Phe Ala Phe Ser Ile Tyr Asp Met Ser 
1               5                   


<210> 137
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 137
Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr 
1               5                   10                  


<210> 138
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 138
Arg His Ser Gly Tyr Gly Thr His Trp Gly Val Leu Phe Ala Tyr 
1               5                   10                  15  


<210> 139
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 139
Gln Asp Ile Ser Asn Tyr Leu Ala 
1               5               


<210> 140
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 140
Leu Leu Ile Tyr Tyr Thr Ser Ile Leu His Ser 
1               5                   10      


<210> 141
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 141
Gln Gln Gly Asn Thr Leu Pro Trp 
1               5               


<210> 142
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 142
Tyr Thr Phe Thr Ser Tyr Trp Leu His 
1               5                   


<210> 143
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 143
Trp Ile Gly Tyr Ile Asn Pro Arg Asn Asp Tyr Thr Glu Tyr 
1               5                   10                  


<210> 144
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 144
Arg Arg Asp Ile Thr Thr Phe Tyr 
1               5               


<210> 145
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 145
Gln Ser Val Leu Tyr Ser Ala Asn His Lys Asn Tyr Leu Ala 
1               5                   10                  


<210> 146
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 146
Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
1               5                   10      


<210> 147
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 147
His Gln Tyr Leu Ser Ser Trp 
1               5           


<210> 148
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 148
Tyr Glu Phe Ser Arg Ser Trp Met Asn 
1               5                   


<210> 149
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 149
Trp Val Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ser Gly 
1               5                   10                  15      


Lys Phe 
        


<210> 150
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 150
Arg Asp Gly Ser Ser Trp Asp Trp Tyr Phe Asp Val 
1               5                   10          


<210> 151
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 151
Gln Ser Ile Val His Ser Val Gly Asn Thr Phe Leu Glu 
1               5                   10              


<210> 152
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 152
Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
1               5                   10      


<210> 153
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 153
Phe Gln Gly Ser Gln Phe Pro Tyr 
1               5               


<210> 154
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 154
Gly Tyr Arg Phe Thr Asn Tyr Trp Ile His 
1               5                   10  


<210> 155
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 155
Gly Ile Asn Pro Gly Asn Asn Tyr Ala Thr Tyr Arg Arg Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 156
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 156
Glu Gly Tyr Gly Asn Tyr Gly Ala Trp Phe Ala Tyr 
1               5                   10          


<210> 157
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 157
Arg Ser Ser Gln Ser Leu Ala Asn Ser Tyr Gly Asn Thr Phe Leu Ser 
1               5                   10                  15      


<210> 158
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 158
Gly Ile Ser Asn Arg Phe Ser 
1               5           


<210> 159
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 159
Leu Gln Gly Thr His Gln Pro Tyr Thr 
1               5                   


<210> 160
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 160
Gly Phe Ala Phe Ser Ile Tyr Asp Met Ser 
1               5                   10  


<210> 161
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 161
Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210> 162
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 162
His Ser Gly Tyr Gly Thr His Trp Gly Val Leu Phe Ala Tyr 
1               5                   10                  


<210> 163
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 163
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210> 164
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 164
Tyr Thr Ser Ile Leu His Ser 
1               5           


<210> 165
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 165
Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210> 166
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 166
Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile Thr 
1               5                   10  


<210> 167
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 167
Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe 
1               5                   10                  15  


<210> 168
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 168
Tyr Gly Asn Tyr Trp Phe Ala Tyr 
1               5               


<210> 169
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 169
Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210> 170
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 170
Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210> 171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 171
Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210> 172
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 172
Tyr Thr Phe Thr Thr Tyr Trp Met His 
1               5                   


<210> 173
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 173
Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Asp Tyr 
1               5                   10                  


<210> 174
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 174
Thr Arg Arg Gly Pro Ser Tyr Gly Asn His Gly Ala Trp Phe Pro Tyr 
1               5                   10                  15      


<210> 175
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 175
Glu Asn Val Asp Thr Tyr Val Ser 
1               5               


<210> 176
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 176
Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr 
1               5                   10      


<210> 177
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 177
Gly Gln Ser Tyr Arg Tyr Pro Pro 
1               5               


<210> 178
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 178
Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210> 179
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 179
Trp Ile Asp Pro Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe 
1               5                   10                  15  


<210> 180
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 180
Lys Thr Thr Gln Thr Thr Trp Gly Phe Pro Phe 
1               5                   10      


<210> 181
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 181
Arg Ala Ser Gln Gly Val Tyr Gln Trp Leu Ala 
1               5                   10      


<210> 182
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 182
Lys Ala Ser His Leu Tyr Asn 
1               5           


<210> 183
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 183
Gln Gln Leu Asn Ser Tyr Pro Leu Thr 
1               5                   


<210> 184
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 184
Gly Tyr Thr Phe Thr Asp Tyr Trp Met His 
1               5                   10  


<210> 185
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 185
Trp Ile Gly Tyr Ile Asn Pro Asn Thr Ala Tyr Thr Asp Tyr 
1               5                   10                  


<210> 186
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 186
Lys Ala Ser Glu Asn Val Asp Ser Phe Val Ser 
1               5                   10      


<210> 187
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 187
Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210> 188
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 188
Gly Gln Asn Tyr Arg Tyr Pro Leu Thr 
1               5                   


<210> 189
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 189
Phe Ser Leu Ile Ser Tyr Gly Val His 
1               5                   


<210> 190
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 190
Trp Leu Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr 
1               5                   10              


<210> 191
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 191
Lys Thr Leu Ile Thr Thr Gly Tyr Ala Met Asp Tyr 
1               5                   10          


<210> 192
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 192
Glu Asp Ile Tyr Asn Arg Leu Ala 
1               5               


<210> 193
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 193
Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly 
1               5                   10          


<210> 194
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 194
Gln Gln Tyr Trp Ser Thr Pro 
1               5           


<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 195
Phe Thr Phe Asn Ser Phe Ala Met Ser 
1               5                   


<210> 196
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 196
Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr 
1               5                   10                  


<210> 197
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 197
Lys Asp Lys Ile Leu Trp Phe Gly Glu Pro Val Phe Asp Tyr 
1               5                   10                  


<210> 198
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 198
Gln Ser Val Ser Ser Tyr Leu Ala 
1               5               


<210> 199
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 199
Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
1               5                   10      


<210> 200
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 200
Gln Gln Arg Ser Asn Trp Pro Pro 
1               5               


<210> 201
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 201
Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   


<210> 202
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 202
Trp Ile Gly Val Met Trp Arg Gly Gly Ser Thr Asp Tyr 
1               5                   10              


<210> 203
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 203
Lys Ser Met Ile Thr Thr Gly Phe Val Met Asp Ser 
1               5                   10          


<210> 204
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 204
Glu Asp Ile Tyr Asn Arg Leu Thr 
1               5               


<210> 205
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 205
Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr 
1               5                   10      


<210> 206
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 206
Gln Gln Tyr Trp Ser Asn Pro Tyr 
1               5               


<210> 207
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 207
Phe Asp Phe Ser Arg Ser Trp Met Asn 
1               5                   


<210> 208
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 208
Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr 
1               5                   10                  


<210> 209
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 209
Arg Tyr Gly Asn Trp Phe Pro Tyr 
1               5               


<210> 210
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 210
Gln Asn Val Asp Thr Asn Val Ala 
1               5               


<210> 211
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 211
Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
1               5                   10      


<210> 212
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 212
Gln Gln Tyr Asp Ser Tyr Pro Leu 
1               5               


<210> 213
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 213
Gly Thr Phe Ser Ser Tyr Ala Phe Ser 
1               5                   


<210> 214
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 214
Trp Met Gly Arg Val Ile Pro Phe Leu Gly Ile Ala Asn Ser 
1               5                   10                  


<210> 215
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 215
Arg Asp Asp Ile Ala Ala Leu Gly Pro Phe Asp Tyr 
1               5                   10          


<210> 216
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 216
Gln Gly Ile Ser Ser Trp Leu Ala 
1               5               


<210> 217
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 217
Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5                   10      


<210> 218
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 218
Gln Gln Tyr Asn Ser Tyr Pro Arg 
1               5               


<210> 219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 219
Tyr Thr Phe Thr Asp Tyr Trp Met Gln 
1               5                   


<210> 220
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 220
Trp Ile Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Gly Tyr 
1               5                   10                  


<210> 221
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 221
Arg Gly Asp Tyr Tyr Gly Ser Asn Ser Leu Asp Tyr 
1               5                   10          


<210> 222
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 222
Gln Asp Val Ser Thr Val Val Ala 
1               5               


<210> 223
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 223
Arg Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ile 
1               5                   10      


<210> 224
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 224
Gln Gln His Tyr Ser Pro Pro Tyr 
1               5               


<210> 225
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 225
Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210> 226
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 226
Val Met Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser 
1               5                   10                  15      


<210> 227
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 227
Ser Met Ile Thr Thr Gly Phe Val Met Asp Ser 
1               5                   10      


<210> 228
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 228
Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr 
1               5                   10      


<210> 229
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 229
Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210> 230
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 230
Gln Gln Tyr Trp Ser Asn Pro Tyr Thr 
1               5                   


<210> 231
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 231
Gly Phe Ser Leu Ile Ser Tyr Gly Val His 
1               5                   10  


<210> 232
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 232
Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser 
1               5                   10                  15      


<210> 233
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 233
Thr Leu Ile Thr Thr Gly Tyr Ala Met Asp Tyr 
1               5                   10      


<210> 234
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 234
Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala 
1               5                   10      


<210> 235
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 235
Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210> 236
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 236
Gln Gln Tyr Trp Ser Thr Pro Thr 
1               5               


<210> 237
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 237
Gly Phe Asp Phe Ser Arg Ser Trp Met Asn 
1               5                   10  


<210> 238
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 238
Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Thr Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210> 239
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 239
Tyr Gly Asn Trp Phe Pro Tyr 
1               5           


<210> 240
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 240
Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210> 241
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 241
Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210> 242
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 242
Gln Gln Tyr Asp Ser Tyr Pro Leu Thr 
1               5                   


<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 243
Phe Asp Phe Ser Arg Tyr Trp Met Ser 
1               5                   


<210> 244
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 244
Trp Ile Gly Glu Ile Asn Pro Thr Ser Ser Thr Ile Asn Phe 
1               5                   10                  


<210> 245
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 245
Arg Gly Asn Tyr Tyr Arg Tyr Gly Asp Ala Met Asp Tyr 
1               5                   10              


<210> 246
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 246
Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10          


<210> 247
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 247
Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
1               5                   10      


<210> 248
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 248
Gln His Ser Arg Glu Leu Pro Phe 
1               5               


<210> 249
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 249
Ser Thr Phe Thr Thr Tyr Trp Ile His 
1               5                   


<210> 250
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 250
Trp Ile Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Glu Tyr 
1               5                   10                  


<210> 251
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 251
Val Arg Phe Ile Thr Val Val Gly Gly 
1               5                   


<210> 252
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 252
Ser Ser Val Ser Ser Ser His Leu His 
1               5                   


<210> 253
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 253
Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210> 254
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 254
His Gln Tyr His Arg Ser Pro Leu 
1               5               


<210> 255
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 255
Phe Ser Leu Thr Thr Tyr Gly Ile Gly Val Gly 
1               5                   10      


<210> 256
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 256
Trp Leu Thr His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr 
1               5                   10              


<210> 257
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 257
Tyr Gly Tyr Thr Tyr 
1               5   


<210> 258
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 258
Gln Ser Leu Leu Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10              


<210> 259
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 259
Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser 
1               5                   10      


<210> 260
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 260
Ser Gln Ser Thr His Val Pro Trp 
1               5               


<210> 261
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 261
Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   


<210> 262
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 262
Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
1               5                   10                  


<210> 263
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 263
Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10          


<210> 264
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 264
Gln Asp Val Asn Thr Ala Val Ala 
1               5               


<210> 265
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 265
Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
1               5                   10      


<210> 266
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 266
Gln Gln His Tyr Thr Thr Pro Pro 
1               5               


<210> 267
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 267
Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val 
1               5                   10          


<210> 268
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 268
Tyr Ser Phe Thr Ser Tyr Trp Ile Ala 
1               5                   


<210> 269
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 269
Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr 
1               5                   10                  


<210> 270
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 270
Arg His Asp Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp Pro 
1               5                   10                  15      


Glu Tyr Phe Gln His 
            20      


<210> 271
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 271
Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10  


<210> 272
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 272
Leu Leu Ile Tyr Gly His Thr Asn Arg Pro Ala 
1               5                   10      


<210> 273
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 273
Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp 
1               5                   10  


<210> 274
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 274
Tyr Pro Phe Thr Asn Tyr Gly Met Asn 
1               5                   


<210> 275
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 275
Trp Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe 
1               5                   10                  


<210> 276
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 276
Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr 
1               5                   10      


<210> 277
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 277
Gln Asp Val Tyr Asn Ala Val Ala 
1               5               


<210> 278
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 278
Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr 
1               5                   10      


<210> 279
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 279
Gln Gln His Phe Arg Thr Pro Phe 
1               5               


<210> 280
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 280
Ile Thr Phe Ser Ile Asn Thr Met Gly 
1               5                   


<210> 281
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 281
Leu Val Ala Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala 
1               5                   10                  


<210> 282
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 282
Lys Arg Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr 
1               5                   10          


<210> 283
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 283
Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   10  


<210> 284
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 284
Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 285
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 285
Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210> 286
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 286
Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210> 287
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 287
Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210> 288
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 288
Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210> 289
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 289
Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   10  


<210> 290
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 290
Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 291
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 291
Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val 
1               5                   10      


<210> 292
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 292
Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210> 293
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 293
Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210> 294
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 294
Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210> 295
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 295
Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Ala 
1               5                   10  


<210> 296
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 296
Leu Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 297
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 297
His Asp Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp Pro Glu 
1               5                   10                  15      


Tyr Phe Gln His 
            20  


<210> 298
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 298
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210> 299
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 299
Gly His Thr Asn Arg Pro Ala 
1               5           


<210> 300
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 300
Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
1               5                   10      


<210> 301
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 301
Gly Ile Thr Phe Ser Ile Asn Thr Met Gly 
1               5                   10  


<210> 302
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 302
Leu Ile Ser Ser Ile Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210> 303
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 303
Phe Arg Thr Ala Ala Gln Gly Thr Asp Tyr 
1               5                   10  


<210> 304
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 304
Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   


<210> 305
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 305
Trp Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr 
1               5                   10                  


<210> 306
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 306
Arg Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   10  


<210> 307
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 307
Gln Asp Val Ser Thr Ala Val Ala 
1               5               


<210> 308
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 308
Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
1               5                   10      


<210> 309
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 309
Gln Gln Tyr Leu Tyr His Pro Ala 
1               5               


<210> 310
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 310
Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   


<210> 311
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 311
Trp Ile Gly Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr 
1               5                   10                  


<210> 312
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 312
Arg Gln Ala Trp Gly Tyr Pro 
1               5           


<210> 313
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 313
Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Val Gln 
1               5                   10          


<210> 314
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 314
Leu Leu Ile Tyr Ala Ala Ser Ser Val Asp Ser 
1               5                   10      


<210> 315
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 315
Gln Gln Ser Arg Arg Val Pro Tyr 
1               5               


<210> 316
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 316
Tyr Thr Phe Thr Ser Tyr Asp Val His 
1               5                   


<210> 317
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 317
Trp Met Gly Trp Leu His Ala Asp Thr Gly Ile Thr Lys Phe 
1               5                   10                  


<210> 318
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 318
Arg Glu Arg Ile Gln Leu Trp Phe Asp Tyr 
1               5                   10  


<210> 319
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 319
Gln Gly Ile Ser Ser Trp Leu Ala 
1               5               


<210> 320
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 320
Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
1               5                   10      


<210> 321
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 321
Gln Gln Tyr Asn Ser Tyr Pro Tyr 
1               5               


<210> 322
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 322
Asp Thr Phe Ser Thr Tyr Ala Ile Ser 
1               5                   


<210> 323
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 323
Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Lys Ala His Tyr 
1               5                   10                  


<210> 324
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 324
Arg Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly Met Asp Val 
1               5                   10                  15  


<210> 325
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 325
Gln Ser Val Ser Ser Tyr Leu Ala 
1               5               


<210> 326
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 326
Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr 
1               5                   10      


<210> 327
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 327
Gln Gln Arg Ser Asn Trp Pro 
1               5           


<210> 328
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 328
Phe Thr Phe Ser Ser Tyr Ile Met Met 
1               5                   


<210> 329
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 329
Trp Val Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr 
1               5                   10                  


<210> 330
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 330
Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr 
1               5                   10          


<210> 331
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 331
Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10      


<210> 332
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 332
Leu Met Ile Tyr Asp Val Ser Asn Arg Pro Ser 
1               5                   10      


<210> 333
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 333
Ser Ser Tyr Thr Ser Ser Ser Thr Arg 
1               5                   


<210> 334
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 334
Gly Phe Asn Ile Lys Asp Tyr Phe Leu His 
1               5                   10  


<210> 335
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 335
Trp Ile Asn Pro Asp Asn Gly Asn Thr Val Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210> 336
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 336
Arg Asp Tyr Thr Tyr Glu Lys Ala Ala Leu Asp Tyr 
1               5                   10          


<210> 337
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 337
Arg Ala Ser Gly Asn Ile Tyr Asn Tyr Leu Ala 
1               5                   10      


<210> 338
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 338
Asp Ala Lys Thr Leu Ala Asp 
1               5           


<210> 339
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 339
Gln His Phe Trp Ser Leu Pro Phe Thr 
1               5                   


<210> 340
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 340
Lys Glu Phe Ile Leu Arg Phe Ser Val Ala His Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 341
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 341
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 342
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 342
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Asn Leu Val Pro Met 
        35                  40                  45              


Val Ala Thr Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 343
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 343
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Leu Gly Phe 
        35                  40                  45              


Val Phe Thr Leu Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 344
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 344
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 345
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 345
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 346
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 346
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 347
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 347
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 348
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 348
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Ile Glu Ala Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Ala Ala Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 349
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 349
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250         


<210> 350
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 350
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 351
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 351
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr Val 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 352
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 352
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Leu Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 353
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 353
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ile Leu Arg Phe Ser Val Ala His Lys Ala Ser 
                245                 250                 255     


Ala Val Ala Ala 
            260 


<210> 354
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 354
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Ala Val Ala Ala 
            260         


<210> 355
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 355
Lys Glu Phe Ile Leu Arg Phe Ser Val Ala His Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 356
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 356
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 357
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 357
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Asn Leu Val Pro Met 
        35                  40                  45              


Val Ala Thr Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 358
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 358
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Leu Gly Phe 
        35                  40                  45              


Val Phe Thr Leu Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 359
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 359
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 360
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 360
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 361
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 361
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 362
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 362
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 363
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 363
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Ile Glu Ala Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Ala Ala Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 364
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 364
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250         


<210> 365
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 365
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 366
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 366
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr Val 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 367
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 367
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Leu Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Arg Val Ala Arg 
                245                 250     


<210> 368
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 368
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ile Leu Arg Phe Ser Val Ala His Lys Ala Ser 
                245                 250                 255     


Arg Val Ala Arg 
            260 


<210> 369
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 369
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Arg Val Ala Arg 
            260         


<210> 370
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 370
Lys Glu Phe Ile Leu Arg Phe Ser Val Ala His Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 371
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 371
Ala Glu Phe Ile Leu Arg Phe Ser Val Ala His Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 372
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 372
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 373
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 373
Lys Glu Phe Ile Leu Arg Phe Ser Val Ala His Lys Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 374
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 374
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Asn Leu Val Pro Met 
        35                  40                  45              


Val Ala Thr Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 375
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 375
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Asn Leu Val Pro Met 
        35                  40                  45              


Val Ala Thr Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Ala Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 376
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 376
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Leu Gly Phe 
        35                  40                  45              


Val Phe Thr Leu Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 377
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 377
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Leu Gly Phe 
        35                  40                  45              


Val Phe Thr Leu Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 378
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 378
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 379
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 379
Lys Glu Phe Ile Leu Asp Phe Ile Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 380
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 380
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 381
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 381
Met Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ile Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 382
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 382
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 383
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 383
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 384
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 384
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 385
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 385
Ala Glu Phe Thr Leu Asp Phe Ile Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 386
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 386
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 387
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 387
Lys Glu Phe Thr Leu Asp Phe Ser Ile Ala Ala Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 388
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 388
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 389
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 389
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 390
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 390
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 391
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 391
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Ala Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 392
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 392
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 393
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 393
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Thr Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 394
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 394
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 395
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 395
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Val Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 396
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 396
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Val Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 397
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 397
Met Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Val Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 398
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 398
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250         


<210> 399
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 399
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250         


<210> 400
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 400
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250         


<210> 401
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 401
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250         


<210> 402
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 402
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 403
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 403
Ala Glu Phe Ile Leu Asp Phe Ile Ala Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 404
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 404
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 405
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 405
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Cys Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 406
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 406
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 407
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 407
Met Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 408
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 408
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 409
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 409
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Ala Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 410
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 410
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 411
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 411
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Cys Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 412
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 412
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 413
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 413
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Ala Thr Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 414
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 414
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 415
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 415
Lys Glu Phe Thr Leu Asp Phe Ile Ile Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Cys Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 416
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 416
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 417
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 417
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Cys Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 418
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 418
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 419
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 419
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 420
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 420
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 421
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 421
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 422
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 422
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 423
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 423
Met Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 424
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 424
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 425
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 425
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 426
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 426
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 427
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 427
Ala Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Cys Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 428
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 428
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 429
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 429
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Ala Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 430
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 430
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 431
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 431
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr Val 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 432
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 432
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Asn Leu Val Pro Met Val Ala Thr Val 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Ala Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 433
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 433
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Leu Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 434
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 434
Ala Glu Phe Ile Leu Asp Phe Ser Ile Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Leu Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala 
                245                 250     


<210> 435
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 435
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ile Leu Arg Phe Ser Val Ala His Lys Ala Ser 
                245                 250                 255     


Ala Val Ala Ala 
            260 


<210> 436
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 436
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Ala Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ile Leu Arg Phe Ser Val Ala His Lys Ala Ser 
                245                 250                 255     


Ala Val Ala Ala 
            260 


<210> 437
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 437
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Ala Val Ala Ala 
            260         


<210> 438
<211> 262
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 438
Met Glu Phe Thr Leu Asp Phe Ile Ile Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Cys Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Ala Thr Asn Asn Ala Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Ala Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Ala Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Ala Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Ala Val Ala Ala 
            260         


<210> 439
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 439
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510     


<210> 440
<211> 519
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 440
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            420                 425                 430         


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        435                 440                 445             


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                485                 490                 495     


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Leu Val Thr Val Ser Ser 
        515                 


<210> 441
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 441
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala 
            500                 505                 510         


<210> 442
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 442
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Asn Leu Val Pro Met Val 
        35                  40                  45              


Ala Thr Val Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala 
            500                 505                 510         


<210> 443
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 443
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ile Gly Asp Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr 
305                 310                 315                 320 


Leu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210> 444
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 444
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510     


<210> 445
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 445
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ile Gly Asp Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr 
305                 310                 315                 320 


Leu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
            500                 505                 510     


<210> 446
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 446
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Gln 
            260                 265                 270         


Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Val His Trp Val 
    290                 295                 300                 


Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
305                 310                 315                 320 


Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr 
                325                 330                 335     


Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser Ser 
            340                 345                 350         


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Asn Tyr 
        355                 360                 365             


Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val Trp Gly Ala Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
385                 390                 395                 400 


Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln Ser Pro Thr Ile Leu 
                405                 410                 415     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser 
            420                 425                 430         


Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
        435                 440                 445             


Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
465                 470                 475                 480 


Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile 
                485                 490                 495     


Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510     


<210> 447
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 447
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser 
305                 310                 315                 320 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    370                 375                 380                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Phe Ser Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Val Ile Pro 
            420                 425                 430         


Phe Leu Gly Ile Ala Asn Ser Ala Gln Lys Phe Gln Gly Arg Val Thr 
        435                 440                 445             


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Asp Leu Ser Ser 
    450                 455                 460                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Asp Ile 
465                 470                 475                 480 


Ala Ala Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210> 448
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 448
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Arg Ala Thr Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Val 
    290                 295                 300                 


Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Val Asp Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile His Pro Val Glu Glu Asp 
            340                 345                 350         


Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Arg Val Pro Tyr Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu 
    370                 375                 380                 


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
                405                 410                 415     


Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            420                 425                 430         


Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr Asn Glu Met Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    450                 455                 460                 


Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
465                 470                 475                 480 


Arg Gln Ala Trp Gly Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ala 
        


<210> 449
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 449
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Arg Ala Thr Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Val 
    290                 295                 300                 


Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Val Asp Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile His Pro Val Glu Glu Asp 
            340                 345                 350         


Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Arg Val Pro Tyr Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
                405                 410                 415     


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            420                 425                 430         


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
        435                 440                 445             


Glu Trp Ile Gly Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr Asn 
    450                 455                 460                 


Glu Met Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
465                 470                 475                 480 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Gln Ala Trp Gly Tyr Pro Trp Gly Gln Gly Thr 
            500                 505                 510         


Leu Val Thr Val Ser Ala 
        515             


<210> 450
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 450
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
        275                 280                 285             


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
305                 310                 315                 320 


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr Phe Gly Gln Gly Thr 
        355                 360                 365             


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
385                 390                 395                 400 


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
                405                 410                 415     


Lys Val Ser Cys Lys Thr Ser Gly Asp Thr Phe Ser Thr Tyr Ala Ile 
            420                 425                 430         


Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly 
        435                 440                 445             


Ile Ile Pro Ile Phe Gly Lys Ala His Tyr Ala Gln Lys Phe Gln Gly 
    450                 455                 460                 


Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
465                 470                 475                 480 


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                485                 490                 495     


Lys Phe His Phe Val Ser Gly Ser Pro Phe Gly Met Asp Val Trp Gly 
            500                 505                 510         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        515                 520     


<210> 451
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 451
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu Val 
            260                 265                 270         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
        275                 280                 285             


Cys Lys Thr Ser Gly Asp Thr Phe Ser Thr Tyr Ala Ile Ser Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro 
305                 310                 315                 320 


Ile Phe Gly Lys Ala His Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
                325                 330                 335     


Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            340                 345                 350         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Lys Phe His 
        355                 360                 365             


Phe Val Ser Gly Ser Pro Phe Gly Met Asp Val Trp Gly Gln Gly Thr 
    370                 375                 380                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
                405                 410                 415     


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
            420                 425                 430         


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
        435                 440                 445             


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
    450                 455                 460                 


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
465                 470                 475                 480 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
                485                 490                 495     


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr Phe 
            500                 505                 510         


Gly Gln Gly Thr Lys Val Glu Ile Lys 
        515                 520     


<210> 452
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 452
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr Met 
    290                 295                 300                 


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln 
    370                 375                 380                 


Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
                405                 410                 415     


Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            420                 425                 430         


Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe Met 
    450                 455                 460                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
465                 470                 475                 480 


Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val 
                485                 490                 495     


Thr Val Ser Ala 
            500 


<210> 453
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 453
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 454
<211> 519
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 454
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            420                 425                 430         


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        435                 440                 445             


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                485                 490                 495     


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Leu Val Thr Val Ser Ser 
        515                 


<210> 455
<211> 515
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 455
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr 
            260                 265                 270         


Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
        275                 280                 285             


Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr 
    290                 295                 300                 


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
305                 310                 315                 320 


Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
            340                 345                 350         


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe 
        355                 360                 365             


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Gln Gln 
385                 390                 395                 400 


Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys 
                405                 410                 415     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys 
            420                 425                 430         


Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr 
        435                 440                 445             


Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu 
    450                 455                 460                 


Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
465                 470                 475                 480 


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr 
                485                 490                 495     


Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210> 456
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 456
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ile 
305                 310                 315                 320 


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Ala Phe Ser Ile Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
            420                 425                 430         


Cys Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr 
        435                 440                 445             


Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    450                 455                 460                 


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
465                 470                 475                 480 


Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr Gly Thr His Trp Gly 
                485                 490                 495     


Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            500                 505                 510         


<210> 457
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 457
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510     


<210> 458
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 458
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Glu Leu Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Phe Ser Val Ser Leu Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys 
                325                 330                 335     


Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr Phe Gly Gly Gly Thr 
        355                 360                 365             


Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    370                 375                 380                 


Gly Glu Gly Ser Lys Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val 
385                 390                 395                 400 


Gln Pro Ser Gln Arg Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
                405                 410                 415     


Leu Ile Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly 
            420                 425                 430         


Leu Glu Trp Leu Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn 
        435                 440                 445             


Ala Ala Phe Met Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser 
    450                 455                 460                 


Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile 
465                 470                 475                 480 


Tyr Phe Cys Ala Lys Thr Leu Ile Thr Thr Gly Tyr Ala Met Asp Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505         


<210> 459
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 459
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 460
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 460
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser 
305                 310                 315                 320 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    370                 375                 380                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His Ala 
            420                 425                 430         


Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val Thr 
        435                 440                 445             


Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    450                 455                 460                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Ile 
465                 470                 475                 480 


Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser 
    


<210> 461
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 461
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro 
305                 310                 315                 320 


Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp 
        355                 360                 365             


Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
385                 390                 395                 400 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                405                 410                 415     


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
            420                 425                 430         


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
        435                 440                 445             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    450                 455                 460                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
465                 470                 475                 480 


Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                485                 490                 495     


Lys 
    


<210> 462
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 462
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 463
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 463
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser 
305                 310                 315                 320 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    370                 375                 380                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His Ala 
            420                 425                 430         


Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val Thr 
        435                 440                 445             


Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    450                 455                 460                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Ile 
465                 470                 475                 480 


Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser 
    


<210> 464
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 464
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro 
305                 310                 315                 320 


Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp 
        355                 360                 365             


Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
385                 390                 395                 400 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                405                 410                 415     


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
            420                 425                 430         


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
        435                 440                 445             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    450                 455                 460                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
465                 470                 475                 480 


Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                485                 490                 495     


Lys 
    


<210> 465
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 465
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 466
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 466
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala 
            500                 505                 510         


<210> 467
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 467
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys 
    370                 375                 380                 


Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr 
        435                 440                 445             


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp 
    450                 455                 460                 


Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr 
                485                 490                 495     


Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            500                 505                 510     


<210> 468
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 468
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Glu Leu Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Phe Ser Val Ser Leu Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys 
                325                 330                 335     


Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr Phe Gly Gly Gly Thr 
        355                 360                 365             


Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    370                 375                 380                 


Gly Glu Gly Ser Lys Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val 
385                 390                 395                 400 


Gln Pro Ser Gln Arg Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
                405                 410                 415     


Leu Ile Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly 
            420                 425                 430         


Leu Glu Trp Leu Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn 
        435                 440                 445             


Ala Ala Phe Met Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser 
    450                 455                 460                 


Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile 
465                 470                 475                 480 


Tyr Phe Cys Ala Lys Thr Leu Ile Thr Thr Gly Tyr Ala Met Asp Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505         


<210> 469
<211> 519
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 469
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            420                 425                 430         


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        435                 440                 445             


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                485                 490                 495     


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Leu Val Thr Val Ser Ser 
        515                 


<210> 470
<211> 515
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 470
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr 
            260                 265                 270         


Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
        275                 280                 285             


Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr 
    290                 295                 300                 


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
305                 310                 315                 320 


Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
            340                 345                 350         


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe 
        355                 360                 365             


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Gln Gln 
385                 390                 395                 400 


Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys 
                405                 410                 415     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys 
            420                 425                 430         


Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr 
        435                 440                 445             


Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu 
    450                 455                 460                 


Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
465                 470                 475                 480 


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr 
                485                 490                 495     


Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210> 471
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 471
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ile 
305                 310                 315                 320 


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Ala Phe Ser Ile Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
            420                 425                 430         


Cys Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr 
        435                 440                 445             


Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    450                 455                 460                 


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
465                 470                 475                 480 


Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr Gly Thr His Trp Gly 
                485                 490                 495     


Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            500                 505                 510         


<210> 472
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 472
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr Met 
    290                 295                 300                 


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln 
    370                 375                 380                 


Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
                405                 410                 415     


Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            420                 425                 430         


Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe Met 
    450                 455                 460                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
465                 470                 475                 480 


Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val 
                485                 490                 495     


Thr Val Ser Ala 
            500 


<210> 473
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 473
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Thr Leu Lys 
            260                 265                 270         


Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr 
        275                 280                 285             


Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Tyr Gly Ile Gly Val Gly 
    290                 295                 300                 


Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Thr His Ile 
305                 310                 315                 320 


Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala Leu Arg Ser Arg Leu 
                325                 330                 335     


Thr Ile Ser Lys Asp Ser Ser Asn Asn Gln Val Leu Leu Lys Ile Ala 
            340                 345                 350         


Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Leu Tyr Gly Tyr 
        355                 360                 365             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    370                 375                 380                 


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
385                 390                 395                 400 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
                405                 410                 415     


Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
            420                 425                 430         


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly 
        435                 440                 445             


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
465                 470                 475                 480 


Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                485                 490                 495     


Ile Lys 
        


<210> 474
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 474
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Arg Ala Thr Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Val 
    290                 295                 300                 


Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Val Asp Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile His Pro Val Glu Glu Asp 
            340                 345                 350         


Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Arg Val Pro Tyr Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu 
    370                 375                 380                 


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
                405                 410                 415     


Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            420                 425                 430         


Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr Asn Glu Met Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    450                 455                 460                 


Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
465                 470                 475                 480 


Arg Gln Ala Trp Gly Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ala 
        


<210> 475
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 475
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 476
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 476
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser 
305                 310                 315                 320 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    370                 375                 380                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
385                 390                 395                 400 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asp Val His Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly Trp Leu His Ala 
            420                 425                 430         


Asp Thr Gly Ile Thr Lys Phe Ser Gln Lys Phe Gln Gly Arg Val Thr 
        435                 440                 445             


Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    450                 455                 460                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Ile 
465                 470                 475                 480 


Gln Leu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser 
    


<210> 477
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 477
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Gly Ile Leu Gly Phe Val Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Glu Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro 
305                 310                 315                 320 


Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp 
        355                 360                 365             


Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
385                 390                 395                 400 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                405                 410                 415     


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
            420                 425                 430         


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
        435                 440                 445             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    450                 455                 460                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
465                 470                 475                 480 


Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                485                 490                 495     


Lys 
    


<210> 478
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 478
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 479
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 479
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
            420                 425                 430         


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        435                 440                 445             


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
    450                 455                 460                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
465                 470                 475                 480 


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala 
            500 


<210> 480
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 480
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Gly Ile Leu Gly Asp Val Phe Thr Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510     


<210> 481
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 481
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510     


<210> 482
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 482
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 483
<211> 519
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 483
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            420                 425                 430         


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        435                 440                 445             


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                485                 490                 495     


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Leu Val Thr Val Ser Ser 
        515                 


<210> 484
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 484
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 485
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 485
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 486
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 486
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
            420                 425                 430         


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        435                 440                 445             


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
    450                 455                 460                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
465                 470                 475                 480 


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala 
            500 


<210> 487
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 487
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr Met 
    290                 295                 300                 


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln 
    370                 375                 380                 


Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
                405                 410                 415     


Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            420                 425                 430         


Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe Met 
    450                 455                 460                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
465                 470                 475                 480 


Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val 
                485                 490                 495     


Thr Val Ser Ala 
            500 


<210> 488
<211> 515
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 488
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Met Thr 
            260                 265                 270         


Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile 
        275                 280                 285             


Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr 
    290                 295                 300                 


Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
305                 310                 315                 320 


Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
            340                 345                 350         


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe 
        355                 360                 365             


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Gln Gln 
385                 390                 395                 400 


Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys 
                405                 410                 415     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys 
            420                 425                 430         


Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr 
        435                 440                 445             


Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu 
    450                 455                 460                 


Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
465                 470                 475                 480 


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr 
                485                 490                 495     


Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            500                 505                 510         


Val Ser Ser 
        515 


<210> 489
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 489
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Val His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Val Trp Phe Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly 
        115                 120                 125             


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Gln Ile Val Leu Ser Gln 
    130                 135                 140                 


Ser Pro Thr Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asp Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr 
        195                 200                 205             


Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser 
                245                 250                 255     


Gly Gly Ala Pro Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr 
            260                 265                 270         


Tyr Val Asp Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu 
        275                 280                 285             


Gln Thr Ile Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly 
    290                 295                 300                 


Ile Gly Asp Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr 
305                 310                 315                 320 


Leu Gly Arg Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu 
                325                 330                 335     


Tyr Val Thr Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe 
            340                 345                 350         


Ala Asp Phe Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu 
        355                 360                 365             


Ser Ala Asp Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser 
    370                 375                 380                 


Arg Thr Gly Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu 
385                 390                 395                 400 


Asp Leu Met Ser His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg 
                405                 410                 415     


Ala Met Leu Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg 
            420                 425                 430         


Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala 
        435                 440                 445             


Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly 
    450                 455                 460                 


Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg 
465                 470                 475                 480 


Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val 
                485                 490                 495     


Ala Leu Ile Leu Asn Ser His His His Ala Ser Ala Val Ala Ala 
            500                 505                 510     


<210> 490
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 490
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Ile 
305                 310                 315                 320 


Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Gly Cys Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Ala Phe Ser Ile Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
            420                 425                 430         


Cys Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr 
        435                 440                 445             


Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    450                 455                 460                 


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
465                 470                 475                 480 


Ala Met Tyr Tyr Cys Ala Arg His Ser Gly Tyr Gly Thr His Trp Gly 
                485                 490                 495     


Val Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            500                 505                 510         


<210> 491
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 491
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 510     


<210> 492
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 492
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Glu Leu Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Phe Ser Val Ser Leu Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Lys 
                325                 330                 335     


Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Thr Phe Gly Gly Gly Thr 
        355                 360                 365             


Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    370                 375                 380                 


Gly Glu Gly Ser Lys Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val 
385                 390                 395                 400 


Gln Pro Ser Gln Arg Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
                405                 410                 415     


Leu Ile Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly 
            420                 425                 430         


Leu Glu Trp Leu Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn 
        435                 440                 445             


Ala Ala Phe Met Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser 
    450                 455                 460                 


Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile 
465                 470                 475                 480 


Tyr Phe Cys Ala Lys Thr Leu Ile Thr Thr Gly Tyr Ala Met Asp Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            500                 505         


<210> 493
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 493
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ile Thr Leu Lys 
            260                 265                 270         


Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr 
        275                 280                 285             


Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Tyr Gly Ile Gly Val Gly 
    290                 295                 300                 


Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Thr His Ile 
305                 310                 315                 320 


Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala Leu Arg Ser Arg Leu 
                325                 330                 335     


Thr Ile Ser Lys Asp Ser Ser Asn Asn Gln Val Leu Leu Lys Ile Ala 
            340                 345                 350         


Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Leu Tyr Gly Tyr 
        355                 360                 365             


Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    370                 375                 380                 


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
385                 390                 395                 400 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
                405                 410                 415     


Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
            420                 425                 430         


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly 
        435                 440                 445             


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    450                 455                 460                 


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
465                 470                 475                 480 


Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                485                 490                 495     


Ile Lys 
        


<210> 494
<211> 519
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 494
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            420                 425                 430         


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        435                 440                 445             


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
465                 470                 475                 480 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                485                 490                 495     


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Leu Val Thr Val Ser Ser 
        515                 


<210> 495
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 495
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Arg Ala Thr Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Val 
    290                 295                 300                 


Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Ser Val Asp Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile His Pro Val Glu Glu Asp 
            340                 345                 350         


Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg Arg Val Pro Tyr Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Glu 
    370                 375                 380                 


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val 
                405                 410                 415     


Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            420                 425                 430         


Tyr Val Asn Pro Phe Asn Asp Gly Thr Lys Tyr Asn Glu Met Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    450                 455                 460                 


Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
465                 470                 475                 480 


Arg Gln Ala Trp Gly Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val 
                485                 490                 495     


Ser Ala 
        


<210> 496
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 496
Ala Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 497
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 497
Ala Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asn Leu Val Pro Met Val Ala Thr Val Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 498
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 498
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Ile Glu Ala Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Ala Ala Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 499
<211> 509
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 499
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Arg Asn Leu Val Pro Met Val Ala Thr Val 
                245                 250                 255     


Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
            260                 265                 270         


Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        275                 280                 285             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
    290                 295                 300                 


Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys 
305                 310                 315                 320 


Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val 
                325                 330                 335     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
            340                 345                 350         


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
        355                 360                 365             


Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
    370                 375                 380                 


Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
385                 390                 395                 400 


Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
                405                 410                 415     


Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly 
            420                 425                 430         


Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser Thr Asp 
        435                 440                 445             


Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp Asn Ser 
    450                 455                 460                 


Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr 
465                 470                 475                 480 


Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe Val Met 
                485                 490                 495     


Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
            500                 505                 


<210> 500
<211> 498
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 500
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210> 501
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 501
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly 
385                 390                 395                 400 


Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
                405                 410                 415     


Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro 
            420                 425                 430         


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg Gly Gly Ser 
        435                 440                 445             


Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile Thr Lys Asp 
    450                 455                 460                 


Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val Thr Ala Ala 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr Thr Gly Phe 
                485                 490                 495     


Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala 
            500                 505                 510         


<210> 502
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 502
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Val Gln Val Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ser Ser Gln Ser Leu Ala Asn Ser Tyr Gly Asn Thr Phe 
    290                 295                 300                 


Leu Ser Trp Tyr Leu His Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
305                 310                 315                 320 


Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            340                 345                 350         


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Thr His Gln Pro Tyr 
        355                 360                 365             


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Asn Tyr 
                405                 410                 415     


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
            420                 425                 430         


Gly Gly Ile Asn Pro Gly Asn Asn Tyr Ala Thr Tyr Arg Arg Lys Phe 
        435                 440                 445             


Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Thr Arg Glu Gly Tyr Gly Asn Tyr Gly Ala Trp Phe Ala Tyr Trp Gly 
                485                 490                 495     


Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            500                 505     


<210> 503
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 503
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Val Leu Thr 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        275                 280                 285             


Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr Met 
    290                 295                 300                 


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr 
305                 310                 315                 320 


Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
                325                 330                 335     


Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu 
            340                 345                 350         


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Trp Thr 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gln 
    370                 375                 380                 


Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
                405                 410                 415     


Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            420                 425                 430         


Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
        435                 440                 445             


Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe Met 
    450                 455                 460                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala 
465                 470                 475                 480 


Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln Val 
                485                 490                 495     


Thr Val Ser Ala 
            500 


<210> 504
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 504
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser Ala 
            


<210> 505
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 505
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Ala Pro Ile Glu Ala Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Ala Ala Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser Ala 
            


<210> 506
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 506
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser Ala 
            


<210> 507
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 507
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser Ala 
            


<210> 508
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 508
Ala Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser Ala 
            


<210> 509
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 509
Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser Ala 
            


<210> 510
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 510
Lys Glu Phe Ile Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr Ser 
305                 310                 315                 320 


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
    370                 375                 380                 


Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr 
385                 390                 395                 400 


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp Val 
                405                 410                 415     


Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp Arg 
            420                 425                 430         


Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn Ile 
        435                 440                 445             


Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser Val 
    450                 455                 460                 


Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile Thr 
465                 470                 475                 480 


Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr Val 
                485                 490                 495     


Ser Ser Ala 
            


<210> 511
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 511
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
305                 310                 315                 320 


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
            420                 425                 430         


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        435                 440                 445             


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
    450                 455                 460                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
465                 470                 475                 480 


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Ala 
            500 


<210> 512
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 512
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Ala Ile Gln Met Ser 
            260                 265                 270         


Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Ile 
        275                 280                 285             


Thr Cys Arg Ala Ser Gly Asn Ile Tyr Asn Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val Tyr Asp Ala Lys Thr 
305                 310                 315                 320 


Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Gln Tyr Ser Leu Lys Ile Ser Ser Leu Gln Thr Glu Asp Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Gln His Phe Trp Ser Leu Pro Phe Thr Phe Gly Ser Gly 
        355                 360                 365             


Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    370                 375                 380                 


Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln Leu Gln Gln Ser Gly 
385                 390                 395                 400 


Ala Glu Leu Val Arg Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Thr 
                405                 410                 415     


Ser Gly Phe Asn Ile Lys Asp Tyr Phe Leu His Trp Val Arg Gln Arg 
            420                 425                 430         


Pro Asp Gln Gly Leu Glu Trp Ile Gly Trp Ile Asn Pro Asp Asn Gly 
        435                 440                 445             


Asn Thr Val Tyr Asp Pro Lys Phe Gln Gly Thr Ala Ser Leu Thr Ala 
    450                 455                 460                 


Asp Thr Ser Ser Asn Thr Val Tyr Leu Gln Leu Ser Gly Leu Thr Ser 
465                 470                 475                 480 


Glu Asp Thr Ala Val Tyr Phe Cys Thr Arg Arg Asp Tyr Thr Tyr Glu 
                485                 490                 495     


Lys Ala Ala Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            500                 505                 510         


Thr 
    


<210> 513
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 513
Ala Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Ala Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys Pro 
                245                 250                 255     


Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Leu Thr 
            260                 265                 270         


Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile 
        275                 280                 285             


Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr 
    290                 295                 300                 


Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile 
305                 310                 315                 320 


Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
            340                 345                 350         


Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser Ser His Val Pro Pro 
        355                 360                 365             


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly 
    370                 375                 380                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln 
385                 390                 395                 400 


Leu Gln Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala Ser Val Lys 
                405                 410                 415     


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Val Asn 
            420                 425                 430         


Trp Ile Lys Gln Ala Pro Gly Gln Gly Leu Gln Trp Met Gly Trp Ile 
        435                 440                 445             


Asn Pro Asn Thr Gly Glu Pro Thr Phe Asp Asp Asp Phe Lys Gly Arg 
    450                 455                 460                 


Phe Ala Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr Leu Gln Ile 
465                 470                 475                 480 


Ser Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Phe Cys Ser Arg Ser 
                485                 490                 495     


Arg Gly Lys Asn Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            500                 505                 510         


Val Thr Val Ser Ser 
        515         


<210> 514
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 514
Lys Asp Glu Leu 
1               


<210> 515
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 515
His Asp Glu Leu 
1               


<210> 516
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 516
Arg Asp Glu Leu 
1               


<210> 517
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 517
Trp Asp Glu Leu 
1               


<210> 518
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 518
Tyr Asp Glu Leu 
1               


<210> 519
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 519
His Glu Glu Leu 
1               


<210> 520
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 520
Lys Glu Glu Leu 
1               


<210> 521
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 521
Arg Glu Glu Leu 
1               


<210> 522
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 522
Lys Phe Glu Leu 
1               


<210> 523
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 523
Lys Ile Glu Leu 
1               


<210> 524
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 524
Asp Lys Glu Leu 
1               


<210> 525
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 525
Lys Lys Glu Leu 
1               


<210> 526
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 526
His Asn Glu Leu 
1               


<210> 527
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 527
His Thr Glu Leu 
1               


<210> 528
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 528
Lys Thr Glu Leu 
1               


<210> 529
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 529
His Val Glu Leu 
1               


<210> 530
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 530
Ala Leu Glu Asp Glu Leu 
1               5       


<210> 531
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 531
His Ala Glu Asp Glu Leu 
1               5       


<210> 532
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 532
His Leu Glu Asp Glu Leu 
1               5       


<210> 533
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 533
Lys Leu Glu Asp Glu Leu 
1               5       


<210> 534
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 534
Ile Arg Ser Asp Glu Leu 
1               5       


<210> 535
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 535
Glu Arg Ser Thr Glu Leu 
1               5       


<210> 536
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 536
Arg Pro Ser Thr Glu Leu 
1               5       


<210> 537
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 537
Arg Val Lys Arg 
1               


<210> 538
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 538
Ala Ser Gly Gly Pro Glu 
1               5       


<210> 539
<211> 54
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (5)..(6) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (10)..(11) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (15)..(16) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (20)..(21) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (25)..(26) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (30)..(31) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (35)..(36) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (40)..(41) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (45)..(46) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (50)..(51) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (3)..(57) 
<223> /note="This region may encompass 1-10 'Gly(2-4)Ser'
      repeating units"

<220>
<221> MISC_FEATURE
<222> (1)..(59)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 539
Ala Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Ala Met 
    50                  


<210> 540
<211> 210
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(6) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (9)..(13) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (16)..(20) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (23)..(27) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (30)..(34) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (37)..(41) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (44)..(48) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (51)..(55) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (58)..(62) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (65)..(69) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (72)..(76) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (79)..(83) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (86)..(90) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (93)..(97) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (100)..(104) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (107)..(111) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (114)..(118) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (121)..(125) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (128)..(132) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (135)..(139) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (142)..(146) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (149)..(153) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (156)..(160) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (163)..(167) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (170)..(174) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (177)..(181) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (184)..(188) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (191)..(195) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (198)..(202) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (205)..(209) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(210) 
<223> /note="This sequence may encompass 1-30 '(Gly)X-Ser'
      repeating units, wherein X represents 1-6"

<220>
<221> MISC_FEATURE
<222> (1)..(210)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 540
Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Ser 
    210 


<210> 541
<211> 210
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(6) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (9)..(13) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (16)..(20) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (23)..(27) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (30)..(34) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (37)..(41) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (44)..(48) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (51)..(55) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (58)..(62) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (65)..(69) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (72)..(76) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (79)..(83) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (86)..(90) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (93)..(97) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (100)..(104) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (107)..(111) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (114)..(118) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (121)..(125) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (128)..(132) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (135)..(139) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (142)..(146) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (149)..(153) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (156)..(160) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (163)..(167) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (170)..(174) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (177)..(181) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (184)..(188) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (191)..(195) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (198)..(202) 
<223> /replace=" "

<220>
<221> VARIANT
<222> (205)..(209) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(210) 
<223> /note="This sequence may encompass 1-30 '(Ser)X-Gly'
      repeating units, wherein X represents 1-6"

<220>
<221> MISC_FEATURE
<222> (1)..(210)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 541
Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
    50                  55                  60                  


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly 
            100                 105                 110         


Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser 
        115                 120                 125             


Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
                165                 170                 175     


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
            180                 185                 190         


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser 
        195                 200                 205             


Ser Gly 
    210 


<210> 542
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MISC_FEATURE
<222> (1)..(150) 
<223> /note="This sequence may encompass 1-30 'Gly-Gly-Gly-
      Gly-Ser' repeating units"

<400> 542
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210> 543
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(30) 
<223> /replace=" "

<220>
<221> MISC_FEATURE
<222> (1)..(30)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 543
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30  


<210> 544
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 544
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210> 545
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 545
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210> 546
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 546
Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210> 547
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 547
Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210> 548
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 548
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210> 549
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 549
Ser Arg Ser Ser Gly 
1               5   


<210> 550
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 550
Ser Gly Ser Ser Cys 
1               5   


<210> 551
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 551
Ala Met Gly Arg Ser Gly Gly Gly Cys Ala Gly Asn Arg Val Gly Ser 
1               5                   10                  15      


Ser Leu Ser Cys Gly Gly Leu Asn Leu Gln Ala Met 
            20                  25              


<210> 552
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 552
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 553
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 553
Gly Gly Ser 
1           


<210> 554
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 554
Gly Gly Gly Ser 
1               


<210> 555
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 555
Gly Gly Gly Gly Ser 
1               5   


<210> 556
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 556
Gly Gly Gly Gly Ser Gly Gly Gly 
1               5               


<210> 557
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 557
Gly Gly Ser Gly Gly Gly Gly 
1               5           


<210> 558
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 558
Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser 
        


<210> 559
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 559
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Ser Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210> 560
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 560
Gly Val Met Thr Arg Gly Arg Leu Lys 
1               5                   


<210> 561
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 561
His Asp Glu Phe 
1               


<210> 562
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 562
Arg Asp Glu Phe 
1               


<210> 563
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 563
His Glu Glu Phe 
1               


<210> 564
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 564
Lys Ala Glu Leu 
1               


<210> 565
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 565
Lys Cys Glu Leu 
1               


<210> 566
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 566
Lys Gly Glu Leu 
1               


<210> 567
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 567
Lys His Glu Leu 
1               


<210> 568
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 568
Lys Leu Glu Leu 
1               


<210> 569
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 569
Lys Asn Glu Leu 
1               


<210> 570
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 570
Lys Gln Glu Leu 
1               


<210> 571
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 571
Lys Arg Glu Leu 
1               


<210> 572
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 572
Lys Ser Glu Leu 
1               


<210> 573
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 573
Lys Val Glu Leu 
1               


<210> 574
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 574
Lys Trp Glu Leu 
1               


<210> 575
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 575
Lys Tyr Glu Leu 
1               


<210> 576
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 576
Lys Glu Asp Leu 
1               


<210> 577
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 577
Phe Asp Glu Leu 
1               


<210> 578
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 578
Lys Asp Glu Phe 
1               


<210> 579
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 579
His Ala Asp Leu 
1               


<210> 580
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 580
His Ala Glu Leu 
1               


<210> 581
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 581
His Ile Glu Leu 
1               


<210> 582
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 582
Asn Asp Glu Leu 
1               


<210> 583
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 583
Gln Asp Glu Leu 
1               


<210> 584
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 584
Arg Glu Asp Leu 
1               


<210> 585
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 585
Arg Asn Glu Leu 
1               


<210> 586
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 586
Arg Thr Asp Leu 
1               


<210> 587
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 587
Arg Thr Glu Leu 
1               


<210> 588
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 588
Ser Asp Glu Leu 
1               


<210> 589
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 589
Thr Asp Glu Leu 
1               


<210> 590
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 590
Ser Lys Glu Leu 
1               


<210> 591
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 591
Ser Thr Glu Leu 
1               


<210> 592
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 592
Glu Asp Glu Leu 
1               


<210> 593
<211> 12
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: Shiga toxin A1
      peptide fragment"

<400> 593
Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe Asn Asn 
1               5                   10          


<210> 594
<211> 10
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: Shiga toxin A1
      peptide fragment"

<400> 594
His Gly Gln Asp Ser Val Arg Val Gly Arg 
1               5                   10  



