                         SEQUENCE LISTING

<110>  WEI, GE
       
 
<120>  COMPOSITIONS AND METHODS FOR TREATING PATIENTS WITH
       RTK MUTANT CELLS

<130>  IGNYT.051WO

<150>  62/168,237          
<151>  2015-05-29

<150>  62/309,900          
<151>  2016-03-17

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  796
<212>  PRT
<213>  Homo sapiens

<220>
<223>  tropomyosin receptor kinase A, TrkA

<220>
<221>  misc_feature
<223>  NCBI Accession Number NP_002520.2

<400>  1

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  2
<211>  277
<212>  PRT
<213>  Homo sapiens

<220>
<223>  kinase domain of tropomyosin receptor kinase A

<220>
<221>  misc_feature
<223>  fragment of the polypeptide sequence at SEQ ID NO: 1

<400>  2

His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly Glu Gly 
1               5                   10                  15      


Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu Pro Glu 
            20                  25                  30          


Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala Ser Glu 
        35                  40                  45              


Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Met Leu 
    50                  55                  60                  


Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu Gly Arg 
65                  70                  75                  80  


Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu Asn Arg 
                85                  90                  95      


Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu 
            100                 105                 110         


Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala Val Ala 
        115                 120                 125             


Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His Phe Val 
    130                 135                 140                 


His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly Leu Val 
145                 150                 155                 160 


Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp 
                165                 170                 175     


Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp Met Pro 
            180                 185                 190         


Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp 
        195                 200                 205             


Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro 
    210                 215                 220                 


Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly 
225                 230                 235                 240 


Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile 
                245                 250                 255     


Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser Ile Lys 
            260                 265                 270         


Asp Val His Ala Arg 
        275         


<210>  3
<211>  838
<212>  PRT
<213>  Homo sapiens

<220>
<223>  tropomyosin receptor kinase B, TrkB

<220>
<221>  misc_feature
<223>  NCBI Accession Number NP_006171.2


<400>  3

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
545                 550                 555                 560 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
                565                 570                 575     


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
            580                 585                 590         


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
        595                 600                 605             


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
    610                 615                 620                 


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
625                 630                 635                 640 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
                645                 650                 655     


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
            660                 665                 670         


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
        675                 680                 685             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
    690                 695                 700                 


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
705                 710                 715                 720 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
                725                 730                 735     


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
            740                 745                 750         


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
        755                 760                 765             


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
    770                 775                 780                 


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
785                 790                 795                 800 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
                805                 810                 815     


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
            820                 825                 830         


Tyr Leu Asp Ile Leu Gly 
        835             


<210>  4
<211>  275
<212>  PRT
<213>  Homo sapiens

<220>
<223>  kinase domain of tropomyosin receptor kinase B

<220>
<221>  misc_feature
<223>  fragment of the polypeptide sequence at SEQ ID NO: 3

<400>  4

His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu Gly Glu Gly 
1               5                   10                  15      


Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Cys Pro Glu 
            20                  25                  30          


Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp Ala Ser Asp 
        35                  40                  45              


Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu Thr Asn Leu 
    50                  55                  60                  


Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val Glu Gly Asp 
65                  70                  75                  80  


Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp Leu Asn Lys 
                85                  90                  95      


Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala Glu Gly Asn 
            100                 105                 110         


Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile Ala Gln Gln 
        115                 120                 125             


Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe Val His Arg 
    130                 135                 140                 


Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu Leu Val Lys 
145                 150                 155                 160 


Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr 
                165                 170                 175     


Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu 
            180                 185                 190         


Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Leu 
        195                 200                 205             


Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr 
    210                 215                 220                 


Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln Gly Arg Val 
225                 230                 235                 240 


Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu Leu Met Leu 
                245                 250                 255     


Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile Lys Gly Ile 
            260                 265                 270         


His Thr Leu 
        275 


<210>  5
<211>  839
<212>  PRT
<213>  Homo sapiens

<220>
<223>  tropomyosin receptor kinase C, TrkC

<220>
<221>  misc_feature
<223>  NCBI Accession Number NP_001012338.1

<400>  5

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe 
705                 710                 715                 720 


Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp 
                725                 730                 735     


Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp 
            740                 745                 750         


Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys 
        755                 760                 765             


Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr 
    770                 775                 780                 


Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr 
785                 790                 795                 800 


Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn 
                805                 810                 815     


Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro 
            820                 825                 830         


Ile Tyr Leu Asp Ile Leu Gly 
        835                 


<210>  6
<211>  292
<212>  PRT
<213>  Homo sapiens

<220>
<223>  kinase domain of tropomyosin receptor kinase C

<220>
<221>  misc_feature
<223>  fragment of the polypeptide sequence at SEQ ID NO: 5

<400>  6

His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu Gly Glu Gly 
1               5                   10                  15      


Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Ser Pro Thr 
            20                  25                  30          


Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp Pro Thr Leu 
        35                  40                  45              


Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Asn Leu 
    50                  55                  60                  


Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly Asp Gly Asp 
65                  70                  75                  80  


Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp Leu Asn Lys 
                85                  90                  95      


Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val Asp Gly Gln 
            100                 105                 110         


Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met Leu His Ile 
        115                 120                 125             


Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser Gln His Phe 
    130                 135                 140                 


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Ala Asn Leu 
145                 150                 155                 160 


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
                165                 170                 175     


Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe Cys Ile Trp 
            180                 185                 190         


Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met Pro Pro 
        195                 200                 205             


Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser 
    210                 215                 220                 


Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp 
225                 230                 235                 240 


Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr Gln Gly Arg 
                245                 250                 255     


Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr Asp Val Met 
            260                 265                 270         


Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn Ile Lys Glu 
        275                 280                 285             


Ile Tyr Lys Ile 
    290         


<210>  7
<211>  1620
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ALK tyrosine kinase receptor, ALK

<220>
<221>  misc_feature
<223>  NCBI Accession Number NP_004295

<400>  7

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  8
<211>  273
<212>  PRT
<213>  Homo sapiens

<220>
<223>  kinase domain of ALK tyrosine kinase

<220>
<221>  misc_feature
<223>  fragment of the polypeptide sequence at SEQ ID NO: 7

<400>  8

Glu Val Pro Arg Lys Asn Ile Thr Leu Ile Arg Gly Leu Gly His Gly 
1               5                   10                  15      


Ala Phe Gly Glu Val Tyr Glu Gly Gln Val Ser Gly Met Pro Asn Asp 
            20                  25                  30          


Pro Ser Pro Leu Gln Val Ala Val Lys Thr Leu Pro Glu Val Cys Ser 
        35                  40                  45              


Glu Gln Asp Glu Leu Asp Phe Leu Met Glu Ala Leu Ile Ile Ser Lys 
    50                  55                  60                  


Phe Asn His Gln Asn Ile Val Arg Cys Ile Gly Val Ser Leu Gln Ser 
65                  70                  75                  80  


Leu Pro Arg Phe Ile Leu Leu Glu Leu Met Ala Gly Gly Asp Leu Lys 
                85                  90                  95      


Ser Phe Leu Arg Glu Thr Arg Pro Arg Pro Ser Gln Pro Ser Ser Leu 
            100                 105                 110         


Ala Met Leu Asp Leu Leu His Val Ala Arg Asp Ile Ala Cys Gly Cys 
        115                 120                 125             


Gln Tyr Leu Glu Glu Asn His Phe Ile His Arg Asp Ile Ala Ala Arg 
    130                 135                 140                 


Asn Cys Leu Leu Thr Cys Pro Gly Pro Gly Arg Val Ala Lys Ile Gly 
145                 150                 155                 160 


Asp Phe Gly Met Ala Arg Asp Ile Tyr Arg Ala Ser Tyr Tyr Arg Lys 
                165                 170                 175     


Gly Gly Cys Ala Met Leu Pro Val Lys Trp Met Pro Pro Glu Ala Phe 
            180                 185                 190         


Met Glu Gly Ile Phe Thr Ser Lys Thr Asp Thr Trp Ser Phe Gly Val 
        195                 200                 205             


Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr Met Pro Tyr Pro Ser Lys 
    210                 215                 220                 


Ser Asn Gln Glu Val Leu Glu Phe Val Thr Ser Gly Gly Arg Met Asp 
225                 230                 235                 240 


Pro Pro Lys Asn Cys Pro Gly Pro Val Tyr Arg Ile Met Thr Gln Cys 
                245                 250                 255     


Trp Gln His Gln Pro Glu Asp Arg Pro Asn Phe Ala Ile Ile Leu Glu 
            260                 265                 270         


Arg 
    


<210>  9
<211>  2347
<212>  PRT
<213>  Homo sapiens

<220>
<223>  proto-oncogene tyrosine-protein kinase ROS, ROS1

<220>
<221>  misc_feature
<223>  NCBI Accession Number NP_002935

<400>  9

Met Lys Asn Ile Tyr Cys Leu Ile Pro Lys Leu Val Asn Phe Ala Thr 
1               5                   10                  15      


Leu Gly Cys Leu Trp Ile Ser Val Val Gln Cys Thr Val Leu Asn Ser 
            20                  25                  30          


Cys Leu Lys Ser Cys Val Thr Asn Leu Gly Gln Gln Leu Asp Leu Gly 
        35                  40                  45              


Thr Pro His Asn Leu Ser Glu Pro Cys Ile Gln Gly Cys His Phe Trp 
    50                  55                  60                  


Asn Ser Val Asp Gln Lys Asn Cys Ala Leu Lys Cys Arg Glu Ser Cys 
65                  70                  75                  80  


Glu Val Gly Cys Ser Ser Ala Glu Gly Ala Tyr Glu Glu Glu Val Leu 
                85                  90                  95      


Glu Asn Ala Asp Leu Pro Thr Ala Pro Phe Ala Ser Ser Ile Gly Ser 
            100                 105                 110         


His Asn Met Thr Leu Arg Trp Lys Ser Ala Asn Phe Ser Gly Val Lys 
        115                 120                 125             


Tyr Ile Ile Gln Trp Lys Tyr Ala Gln Leu Leu Gly Ser Trp Thr Tyr 
    130                 135                 140                 


Thr Lys Thr Val Ser Arg Pro Ser Tyr Val Val Lys Pro Leu His Pro 
145                 150                 155                 160 


Phe Thr Glu Tyr Ile Phe Arg Val Val Trp Ile Phe Thr Ala Gln Leu 
                165                 170                 175     


Gln Leu Tyr Ser Pro Pro Ser Pro Ser Tyr Arg Thr His Pro His Gly 
            180                 185                 190         


Val Pro Glu Thr Ala Pro Leu Ile Arg Asn Ile Glu Ser Ser Ser Pro 
        195                 200                 205             


Asp Thr Val Glu Val Ser Trp Asp Pro Pro Gln Phe Pro Gly Gly Pro 
    210                 215                 220                 


Ile Leu Gly Tyr Asn Leu Arg Leu Ile Ser Lys Asn Gln Lys Leu Asp 
225                 230                 235                 240 


Ala Gly Thr Gln Arg Thr Ser Phe Gln Phe Tyr Ser Thr Leu Pro Asn 
                245                 250                 255     


Thr Ile Tyr Arg Phe Ser Ile Ala Ala Val Asn Glu Val Gly Glu Gly 
            260                 265                 270         


Pro Glu Ala Glu Ser Ser Ile Thr Thr Ser Ser Ser Ala Val Gln Gln 
        275                 280                 285             


Glu Glu Gln Trp Leu Phe Leu Ser Arg Lys Thr Ser Leu Arg Lys Arg 
    290                 295                 300                 


Ser Leu Lys His Leu Val Asp Glu Ala His Cys Leu Arg Leu Asp Ala 
305                 310                 315                 320 


Ile Tyr His Asn Ile Thr Gly Ile Ser Val Asp Val His Gln Gln Ile 
                325                 330                 335     


Val Tyr Phe Ser Glu Gly Thr Leu Ile Trp Ala Lys Lys Ala Ala Asn 
            340                 345                 350         


Met Ser Asp Val Ser Asp Leu Arg Ile Phe Tyr Arg Gly Ser Gly Leu 
        355                 360                 365             


Ile Ser Ser Ile Ser Ile Asp Trp Leu Tyr Gln Arg Met Tyr Phe Ile 
    370                 375                 380                 


Met Asp Glu Leu Val Cys Val Cys Asp Leu Glu Asn Cys Ser Asn Ile 
385                 390                 395                 400 


Glu Glu Ile Thr Pro Pro Ser Ile Ser Ala Pro Gln Lys Ile Val Ala 
                405                 410                 415     


Asp Ser Tyr Asn Gly Tyr Val Phe Tyr Leu Leu Arg Asp Gly Ile Tyr 
            420                 425                 430         


Arg Ala Asp Leu Pro Val Pro Ser Gly Arg Cys Ala Glu Ala Val Arg 
        435                 440                 445             


Ile Val Glu Ser Cys Thr Leu Lys Asp Phe Ala Ile Lys Pro Gln Ala 
    450                 455                 460                 


Lys Arg Ile Ile Tyr Phe Asn Asp Thr Ala Gln Val Phe Met Ser Thr 
465                 470                 475                 480 


Phe Leu Asp Gly Ser Ala Ser His Leu Ile Leu Pro Arg Ile Pro Phe 
                485                 490                 495     


Ala Asp Val Lys Ser Phe Ala Cys Glu Asn Asn Asp Phe Leu Val Thr 
            500                 505                 510         


Asp Gly Lys Val Ile Phe Gln Gln Asp Ala Leu Ser Phe Asn Glu Phe 
        515                 520                 525             


Ile Val Gly Cys Asp Leu Ser His Ile Glu Glu Phe Gly Phe Gly Asn 
    530                 535                 540                 


Leu Val Ile Phe Gly Ser Ser Ser Gln Leu His Pro Leu Pro Gly Arg 
545                 550                 555                 560 


Pro Gln Glu Leu Ser Val Leu Phe Gly Ser His Gln Ala Leu Val Gln 
                565                 570                 575     


Trp Lys Pro Pro Ala Leu Ala Ile Gly Ala Asn Val Ile Leu Ile Ser 
            580                 585                 590         


Asp Ile Ile Glu Leu Phe Glu Leu Gly Pro Ser Ala Trp Gln Asn Trp 
        595                 600                 605             


Thr Tyr Glu Val Lys Val Ser Thr Gln Asp Pro Pro Glu Val Thr His 
    610                 615                 620                 


Ile Phe Leu Asn Ile Ser Gly Thr Met Leu Asn Val Pro Glu Leu Gln 
625                 630                 635                 640 


Ser Ala Met Lys Tyr Lys Val Ser Val Arg Ala Ser Ser Pro Lys Arg 
                645                 650                 655     


Pro Gly Pro Trp Ser Glu Pro Ser Val Gly Thr Thr Leu Val Pro Ala 
            660                 665                 670         


Ser Glu Pro Pro Phe Ile Met Ala Val Lys Glu Asp Gly Leu Trp Ser 
        675                 680                 685             


Lys Pro Leu Asn Ser Phe Gly Pro Gly Glu Phe Leu Ser Ser Asp Ile 
    690                 695                 700                 


Gly Asn Val Ser Asp Met Asp Trp Tyr Asn Asn Ser Leu Tyr Tyr Ser 
705                 710                 715                 720 


Asp Thr Lys Gly Asp Val Phe Val Trp Leu Leu Asn Gly Thr Asp Ile 
                725                 730                 735     


Ser Glu Asn Tyr His Leu Pro Ser Ile Ala Gly Ala Gly Ala Leu Ala 
            740                 745                 750         


Phe Glu Trp Leu Gly His Phe Leu Tyr Trp Ala Gly Lys Thr Tyr Val 
        755                 760                 765             


Ile Gln Arg Gln Ser Val Leu Thr Gly His Thr Asp Ile Val Thr His 
    770                 775                 780                 


Val Lys Leu Leu Val Asn Asp Met Val Val Asp Ser Val Gly Gly Tyr 
785                 790                 795                 800 


Leu Tyr Trp Thr Thr Leu Tyr Ser Val Glu Ser Thr Arg Leu Asn Gly 
                805                 810                 815     


Glu Ser Ser Leu Val Leu Gln Thr Gln Pro Trp Phe Ser Gly Lys Lys 
            820                 825                 830         


Val Ile Ala Leu Thr Leu Asp Leu Ser Asp Gly Leu Leu Tyr Trp Leu 
        835                 840                 845             


Val Gln Asp Ser Gln Cys Ile His Leu Tyr Thr Ala Val Leu Arg Gly 
    850                 855                 860                 


Gln Ser Thr Gly Asp Thr Thr Ile Thr Glu Phe Ala Ala Trp Ser Thr 
865                 870                 875                 880 


Ser Glu Ile Ser Gln Asn Ala Leu Met Tyr Tyr Ser Gly Arg Leu Phe 
                885                 890                 895     


Trp Ile Asn Gly Phe Arg Ile Ile Thr Thr Gln Glu Ile Gly Gln Lys 
            900                 905                 910         


Thr Ser Val Ser Val Leu Glu Pro Ala Arg Phe Asn Gln Phe Thr Ile 
        915                 920                 925             


Ile Gln Thr Ser Leu Lys Pro Leu Pro Gly Asn Phe Ser Phe Thr Pro 
    930                 935                 940                 


Lys Val Ile Pro Asp Ser Val Gln Glu Ser Ser Phe Arg Ile Glu Gly 
945                 950                 955                 960 


Asn Ala Ser Ser Phe Gln Ile Leu Trp Asn Gly Pro Pro Ala Val Asp 
                965                 970                 975     


Trp Gly Val Val Phe Tyr Ser Val Glu Phe Ser Ala His Ser Lys Phe 
            980                 985                 990         


Leu Ala Ser Glu Gln His Ser Leu  Pro Val Phe Thr Val  Glu Gly Leu 
        995                 1000                 1005             


Glu Pro  Tyr Ala Leu Phe Asn  Leu Ser Val Thr Pro  Tyr Thr Tyr 
    1010                 1015                 1020             


Trp Gly  Lys Gly Pro Lys Thr  Ser Leu Ser Leu Arg  Ala Pro Glu 
    1025                 1030                 1035             


Thr Val  Pro Ser Ala Pro Glu  Asn Pro Arg Ile Phe  Ile Leu Pro 
    1040                 1045                 1050             


Ser Gly  Lys Cys Cys Asn Lys  Asn Glu Val Val Val  Glu Phe Arg 
    1055                 1060                 1065             


Trp Asn  Lys Pro Lys His Glu  Asn Gly Val Leu Thr  Lys Phe Glu 
    1070                 1075                 1080             


Ile Phe  Tyr Asn Ile Ser Asn  Gln Ser Ile Thr Asn  Lys Thr Cys 
    1085                 1090                 1095             


Glu Asp  Trp Ile Ala Val Asn  Val Thr Pro Ser Val  Met Ser Phe 
    1100                 1105                 1110             


Gln Leu  Glu Gly Met Ser Pro  Arg Cys Phe Ile Ala  Phe Gln Val 
    1115                 1120                 1125             


Arg Ala  Phe Thr Ser Lys Gly  Pro Gly Pro Tyr Ala  Asp Val Val 
    1130                 1135                 1140             


Lys Ser  Thr Thr Ser Glu Ile  Asn Pro Phe Pro His  Leu Ile Thr 
    1145                 1150                 1155             


Leu Leu  Gly Asn Lys Ile Val  Phe Leu Asp Met Asp  Gln Asn Gln 
    1160                 1165                 1170             


Val Val  Trp Thr Phe Ser Ala  Glu Arg Val Ile Ser  Ala Val Cys 
    1175                 1180                 1185             


Tyr Thr  Ala Asp Asn Glu Met  Gly Tyr Tyr Ala Glu  Gly Asp Ser 
    1190                 1195                 1200             


Leu Phe  Leu Leu His Leu His  Asn Arg Ser Ser Ser  Glu Leu Phe 
    1205                 1210                 1215             


Gln Asp  Ser Leu Val Phe Asp  Ile Thr Val Ile Thr  Ile Asp Trp 
    1220                 1225                 1230             


Ile Ser  Arg His Leu Tyr Phe  Ala Leu Lys Glu Ser  Gln Asn Gly 
    1235                 1240                 1245             


Met Gln  Val Phe Asp Val Asp  Leu Glu His Lys Val  Lys Tyr Pro 
    1250                 1255                 1260             


Arg Glu  Val Lys Ile His Asn  Arg Asn Ser Thr Ile  Ile Ser Phe 
    1265                 1270                 1275             


Ser Val  Tyr Pro Leu Leu Ser  Arg Leu Tyr Trp Thr  Glu Val Ser 
    1280                 1285                 1290             


Asn Phe  Gly Tyr Gln Met Phe  Tyr Tyr Ser Ile Ile  Ser His Thr 
    1295                 1300                 1305             


Leu His  Arg Ile Leu Gln Pro  Thr Ala Thr Asn Gln  Gln Asn Lys 
    1310                 1315                 1320             


Arg Asn  Gln Cys Ser Cys Asn  Val Thr Glu Phe Glu  Leu Ser Gly 
    1325                 1330                 1335             


Ala Met  Ala Ile Asp Thr Ser  Asn Leu Glu Lys Pro  Leu Ile Tyr 
    1340                 1345                 1350             


Phe Ala  Lys Ala Gln Glu Ile  Trp Ala Met Asp Leu  Glu Gly Cys 
    1355                 1360                 1365             


Gln Cys  Trp Arg Val Ile Thr  Val Pro Ala Met Leu  Ala Gly Lys 
    1370                 1375                 1380             


Thr Leu  Val Ser Leu Thr Val  Asp Gly Asp Leu Ile  Tyr Trp Ile 
    1385                 1390                 1395             


Ile Thr  Ala Lys Asp Ser Thr  Gln Ile Tyr Gln Ala  Lys Lys Gly 
    1400                 1405                 1410             


Asn Gly  Ala Ile Val Ser Gln  Val Lys Ala Leu Arg  Ser Arg His 
    1415                 1420                 1425             


Ile Leu  Ala Tyr Ser Ser Val  Met Gln Pro Phe Pro  Asp Lys Ala 
    1430                 1435                 1440             


Phe Leu  Ser Leu Ala Ser Asp  Thr Val Glu Pro Thr  Ile Leu Asn 
    1445                 1450                 1455             


Ala Thr  Asn Thr Ser Leu Thr  Ile Arg Leu Pro Leu  Ala Lys Thr 
    1460                 1465                 1470             


Asn Leu  Thr Trp Tyr Gly Ile  Thr Ser Pro Thr Pro  Thr Tyr Leu 
    1475                 1480                 1485             


Val Tyr  Tyr Ala Glu Val Asn  Asp Arg Lys Asn Ser  Ser Asp Leu 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Leu Glu Phe  Gln Asp Ser Ile Ala  Leu Ile Glu 
    1505                 1510                 1515             


Asp Leu  Gln Pro Phe Ser Thr  Tyr Met Ile Gln Ile  Ala Val Lys 
    1520                 1525                 1530             


Asn Tyr  Tyr Ser Asp Pro Leu  Glu His Leu Pro Pro  Gly Lys Glu 
    1535                 1540                 1545             


Ile Trp  Gly Lys Thr Lys Asn  Gly Val Pro Glu Ala  Val Gln Leu 
    1550                 1555                 1560             


Ile Asn  Thr Thr Val Arg Ser  Asp Thr Ser Leu Ile  Ile Ser Trp 
    1565                 1570                 1575             


Arg Glu  Ser His Lys Pro Asn  Gly Pro Lys Glu Ser  Val Arg Tyr 
    1580                 1585                 1590             


Gln Leu  Ala Ile Ser His Leu  Ala Leu Ile Pro Glu  Thr Pro Leu 
    1595                 1600                 1605             


Arg Gln  Ser Glu Phe Pro Asn  Gly Arg Leu Thr Leu  Leu Val Thr 
    1610                 1615                 1620             


Arg Leu  Ser Gly Gly Asn Ile  Tyr Val Leu Lys Val  Leu Ala Cys 
    1625                 1630                 1635             


His Ser  Glu Glu Met Trp Cys  Thr Glu Ser His Pro  Val Thr Val 
    1640                 1645                 1650             


Glu Met  Phe Asn Thr Pro Glu  Lys Pro Tyr Ser Leu  Val Pro Glu 
    1655                 1660                 1665             


Asn Thr  Ser Leu Gln Phe Asn  Trp Lys Ala Pro Leu  Asn Val Asn 
    1670                 1675                 1680             


Leu Ile  Arg Phe Trp Val Glu  Leu Gln Lys Trp Lys  Tyr Asn Glu 
    1685                 1690                 1695             


Phe Tyr  His Val Lys Thr Ser  Cys Ser Gln Gly Pro  Ala Tyr Val 
    1700                 1705                 1710             


Cys Asn  Ile Thr Asn Leu Gln  Pro Tyr Thr Ser Tyr  Asn Val Arg 
    1715                 1720                 1725             


Val Val  Val Val Tyr Lys Thr  Gly Glu Asn Ser Thr  Ser Leu Pro 
    1730                 1735                 1740             


Glu Ser  Phe Lys Thr Lys Ala  Gly Val Pro Asn Lys  Pro Gly Ile 
    1745                 1750                 1755             


Pro Lys  Leu Leu Glu Gly Ser  Lys Asn Ser Ile Gln  Trp Glu Lys 
    1760                 1765                 1770             


Ala Glu  Asp Asn Gly Cys Arg  Ile Thr Tyr Tyr Ile  Leu Glu Ile 
    1775                 1780                 1785             


Arg Lys  Ser Thr Ser Asn Asn  Leu Gln Asn Gln Asn  Leu Arg Trp 
    1790                 1795                 1800             


Lys Met  Thr Phe Asn Gly Ser  Cys Ser Ser Val Cys  Thr Trp Lys 
    1805                 1810                 1815             


Ser Lys  Asn Leu Lys Gly Ile  Phe Gln Phe Arg Val  Val Ala Ala 
    1820                 1825                 1830             


Asn Asn  Leu Gly Phe Gly Glu  Tyr Ser Gly Ile Ser  Glu Asn Ile 
    1835                 1840                 1845             


Ile Leu  Val Gly Asp Asp Phe  Trp Ile Pro Glu Thr  Ser Phe Ile 
    1850                 1855                 1860             


Leu Thr  Ile Ile Val Gly Ile  Phe Leu Val Val Thr  Ile Pro Leu 
    1865                 1870                 1875             


Thr Phe  Val Trp His Arg Arg  Leu Lys Asn Gln Lys  Ser Ala Lys 
    1880                 1885                 1890             


Glu Gly  Val Thr Val Leu Ile  Asn Glu Asp Lys Glu  Leu Ala Glu 
    1895                 1900                 1905             


Leu Arg  Gly Leu Ala Ala Gly  Val Gly Leu Ala Asn  Ala Cys Tyr 
    1910                 1915                 1920             


Ala Ile  His Thr Leu Pro Thr  Gln Glu Glu Ile Glu  Asn Leu Pro 
    1925                 1930                 1935             


Ala Phe  Pro Arg Glu Lys Leu  Thr Leu Arg Leu Leu  Leu Gly Ser 
    1940                 1945                 1950             


Gly Ala  Phe Gly Glu Val Tyr  Glu Gly Thr Ala Val  Asp Ile Leu 
    1955                 1960                 1965             


Gly Val  Gly Ser Gly Glu Ile  Lys Val Ala Val Lys  Thr Leu Lys 
    1970                 1975                 1980             


Lys Gly  Ser Thr Asp Gln Glu  Lys Ile Glu Phe Leu  Lys Glu Ala 
    1985                 1990                 1995             


His Leu  Met Ser Lys Phe Asn  His Pro Asn Ile Leu  Lys Gln Leu 
    2000                 2005                 2010             


Gly Val  Cys Leu Leu Asn Glu  Pro Gln Tyr Ile Ile  Leu Glu Leu 
    2015                 2020                 2025             


Met Glu  Gly Gly Asp Leu Leu  Thr Tyr Leu Arg Lys  Ala Arg Met 
    2030                 2035                 2040             


Ala Thr  Phe Tyr Gly Pro Leu  Leu Thr Leu Val Asp  Leu Val Asp 
    2045                 2050                 2055             


Leu Cys  Val Asp Ile Ser Lys  Gly Cys Val Tyr Leu  Glu Arg Met 
    2060                 2065                 2070             


His Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Ser 
    2075                 2080                 2085             


Val Lys  Asp Tyr Thr Ser Pro  Arg Ile Val Lys Ile  Gly Asp Phe 
    2090                 2095                 2100             


Gly Leu  Ala Arg Asp Ile Tyr  Lys Asn Asp Tyr Tyr  Arg Lys Arg 
    2105                 2110                 2115             


Gly Glu  Gly Leu Leu Pro Val  Arg Trp Met Ala Pro  Glu Ser Leu 
    2120                 2125                 2130             


Met Asp  Gly Ile Phe Thr Thr  Gln Ser Asp Val Trp  Ser Phe Gly 
    2135                 2140                 2145             


Ile Leu  Ile Trp Glu Ile Leu  Thr Leu Gly His Gln  Pro Tyr Pro 
    2150                 2155                 2160             


Ala His  Ser Asn Leu Asp Val  Leu Asn Tyr Val Gln  Thr Gly Gly 
    2165                 2170                 2175             


Arg Leu  Glu Pro Pro Arg Asn  Cys Pro Asp Asp Leu  Trp Asn Leu 
    2180                 2185                 2190             


Met Thr  Gln Cys Trp Ala Gln  Glu Pro Asp Gln Arg  Pro Thr Phe 
    2195                 2200                 2205             


His Arg  Ile Gln Asp Gln Leu  Gln Leu Phe Arg Asn  Phe Phe Leu 
    2210                 2215                 2220             


Asn Ser  Ile Tyr Lys Ser Arg  Asp Glu Ala Asn Asn  Ser Gly Val 
    2225                 2230                 2235             


Ile Asn  Glu Ser Phe Glu Gly  Glu Asp Gly Asp Val  Ile Cys Leu 
    2240                 2245                 2250             


Asn Ser  Asp Asp Ile Met Pro  Val Ala Leu Met Glu  Thr Lys Asn 
    2255                 2260                 2265             


Arg Glu  Gly Leu Asn Tyr Met  Val Leu Ala Thr Glu  Cys Gly Gln 
    2270                 2275                 2280             


Gly Glu  Glu Lys Ser Glu Gly  Pro Leu Gly Ser Gln  Glu Ser Glu 
    2285                 2290                 2295             


Ser Cys  Gly Leu Arg Lys Glu  Glu Lys Glu Pro His  Ala Asp Lys 
    2300                 2305                 2310             


Asp Phe  Cys Gln Glu Lys Gln  Val Ala Tyr Cys Pro  Ser Gly Lys 
    2315                 2320                 2325             


Pro Glu  Gly Leu Asn Tyr Ala  Cys Leu Thr His Ser  Gly Tyr Gly 
    2330                 2335                 2340             


Asp Gly  Ser Asp 
    2345         



<210>  10
<211>  276
<212>  PRT
<213>  Homo sapiens

<220>
<223>  kinase domain of ROS1

<220>
<221>  misc_feature
<223>  fragment of the polypeptide sequence at SEQ ID NO: 9

<400>  10

Ala Phe Pro Arg Glu Lys Leu Thr Leu Arg Leu Leu Leu Gly Ser Gly 
1               5                   10                  15      


Ala Phe Gly Glu Val Tyr Glu Gly Thr Ala Val Asp Ile Leu Gly Val 
            20                  25                  30          


Gly Ser Gly Glu Ile Lys Val Ala Val Lys Thr Leu Lys Lys Gly Ser 
        35                  40                  45              


Thr Asp Gln Glu Lys Ile Glu Phe Leu Lys Glu Ala His Leu Met Ser 
    50                  55                  60                  


Lys Phe Asn His Pro Asn Ile Leu Lys Gln Leu Gly Val Cys Leu Leu 
65                  70                  75                  80  


Asn Glu Pro Gln Tyr Ile Ile Leu Glu Leu Met Glu Gly Gly Asp Leu 
                85                  90                  95      


Leu Thr Tyr Leu Arg Lys Ala Arg Met Ala Thr Phe Tyr Gly Pro Leu 
            100                 105                 110         


Leu Thr Leu Val Asp Leu Val Asp Leu Cys Val Asp Ile Ser Lys Gly 
        115                 120                 125             


Cys Val Tyr Leu Glu Arg Met His Phe Ile His Arg Asp Leu Ala Ala 
    130                 135                 140                 


Arg Asn Cys Leu Val Ser Val Lys Asp Tyr Thr Ser Pro Arg Ile Val 
145                 150                 155                 160 


Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asn Asp Tyr 
                165                 170                 175     


Tyr Arg Lys Arg Gly Glu Gly Leu Leu Pro Val Arg Trp Met Ala Pro 
            180                 185                 190         


Glu Ser Leu Met Asp Gly Ile Phe Thr Thr Gln Ser Asp Val Trp Ser 
        195                 200                 205             


Phe Gly Ile Leu Ile Trp Glu Ile Leu Thr Leu Gly His Gln Pro Tyr 
    210                 215                 220                 


Pro Ala His Ser Asn Leu Asp Val Leu Asn Tyr Val Gln Thr Gly Gly 
225                 230                 235                 240 


Arg Leu Glu Pro Pro Arg Asn Cys Pro Asp Asp Leu Trp Asn Leu Met 
                245                 250                 255     


Thr Gln Cys Trp Ala Gln Glu Pro Asp Gln Arg Pro Thr Phe His Arg 
            260                 265                 270         


Ile Gln Asp Gln 
        275     


