                         SEQUENCE LISTING

<110>  Ospedale San Raffaele S.r.l.
 
<120>  Inhibitor of IGFBP3/TMEM219 axis and diabetes

<130>  PCT129932

<150>  EP15170679.3
<151>  2015-06-04

<150>  EP16169222.3
<151>  2016-05-11

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Asn Cys Gln Ala Gly His Asn Leu His Leu Cys Leu Ala His 
1               5                   10                  15      


His Pro Pro Leu Val Cys Ala Thr Leu Ile Leu Leu Leu Leu Gly Leu 
            20                  25                  30          


Ser Gly Leu Gly Leu Gly Ser Phe Leu Leu Thr His Arg Thr Gly Leu 
        35                  40                  45              


Arg Ser Pro Asp Ile Pro Gln Asp Trp Val Ser Phe Leu Arg Ser Phe 
    50                  55                  60                  


Gly Gln Leu Thr Leu Cys Pro Arg Asn Gly Thr Val Thr Gly Lys Trp 
65                  70                  75                  80  


Arg Gly Ser His Val Val Gly Leu Leu Thr Thr Leu Asn Phe Gly Asp 
                85                  90                  95      


Gly Pro Asp Arg Asn Lys Thr Arg Thr Phe Gln Ala Thr Val Leu Gly 
            100                 105                 110         


Ser Gln Met Gly Leu Lys Gly Ser Ser Ala Gly Gln Leu Val Leu Ile 
        115                 120                 125             


Thr Ala Arg Val Thr Thr Glu Arg Thr Ala Gly Thr Cys Leu Tyr Phe 
    130                 135                 140                 


Ser Ala Val Pro Gly Ile Leu Pro Ser Ser Gln Pro Pro Ile Ser Cys 
145                 150                 155                 160 


Ser Glu Glu Gly Ala Gly Asn Ala Thr Leu Ser Pro Arg Met Gly Glu 
                165                 170                 175     


Glu Cys Val Ser Val Trp Ser His Glu Gly Leu Val Leu Thr Lys Leu 
            180                 185                 190         


Leu Thr Ser Glu Glu Leu Ala Leu Cys Gly Ser Arg Leu Leu Val Leu 
        195                 200                 205             


Gly Ser Phe Leu Leu Leu Phe Cys Gly Leu Leu Cys Cys Val Thr Ala 
    210                 215                 220                 


Met Cys Phe His Pro Arg Arg Glu Ser His Trp Ser Arg Thr Arg Leu 
225                 230                 235                 240 


<210>  2
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr His Arg Thr Gly Leu Arg Ser Pro Asp Ile Pro Gln Asp Trp Val 
1               5                   10                  15      


Ser Phe Leu Arg Ser Phe Gly Gln Leu Thr Leu Cys Pro Arg Asn Gly 
            20                  25                  30          


Thr Val Thr Gly Lys Trp Arg Gly Ser His Val Val Gly Leu Leu Thr 
        35                  40                  45              


Thr Leu Asn Phe Gly Asp Gly Pro Asp Arg Asn Lys Thr Arg Thr Phe 
    50                  55                  60                  


Gln Ala Thr Val Leu Gly Ser Gln Met Gly Leu Lys Gly Ser Ser Ala 
65                  70                  75                  80  


Gly Gln Leu Val Leu Ile Thr Ala Arg Val Thr Thr Glu Arg Thr Ala 
                85                  90                  95      


Gly Thr Cys Leu Tyr Phe Ser Ala Val Pro Gly Ile Leu Pro Ser Ser 
            100                 105                 110         


Gln Pro Pro Ile Ser Cys Ser Glu Glu Gly Ala Gly Asn Ala Thr Leu 
        115                 120                 125             


Ser Pro Arg Met Gly Glu Glu Cys Val Ser Val Trp Ser His Glu Gly 
    130                 135                 140                 


Leu Val Leu Thr Lys Leu Leu Thr Ser Glu Glu Leu Ala Leu Cys Gly 
145                 150                 155                 160 


Ser Arg 
        


<210>  3
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Phe Leu Leu Thr His Arg Thr Gly Leu Arg Ser Pro Asp Ile Pro 
1               5                   10                  15      


Gln Asp Trp Val Ser Phe Leu Arg Ser Phe Gly Gln Leu Thr Leu Cys 
            20                  25                  30          


Pro Arg Asn Gly Thr Val Thr Gly Lys Trp Arg Gly Ser His Val Val 
        35                  40                  45              


Gly Leu Leu Thr Thr Leu Asn Phe Gly Asp Gly Pro Asp Arg Asn Lys 
    50                  55                  60                  


Thr Arg Thr Phe Gln Ala Thr Val Leu Gly Ser Gln Met Gly Leu Lys 
65                  70                  75                  80  


Gly Ser Ser Ala Gly Gln Leu Val Leu Ile Thr Ala Arg Val Thr Thr 
                85                  90                  95      


Glu Arg Thr Ala Gly Thr Cys Leu Tyr Phe Ser Ala Val Pro Gly Ile 
            100                 105                 110         


Leu Pro Ser Ser Gln Pro Pro Ile Ser Cys Ser Glu Glu Gly Ala Gly 
        115                 120                 125             


Asn Ala Thr Leu Ser Pro Arg Met Gly Glu Glu Cys Val Ser Val Trp 
    130                 135                 140                 


Ser His Glu Gly Leu Val Leu Thr Lys Leu Leu Thr Ser Glu Glu Leu 
145                 150                 155                 160 


Ala Leu Cys Gly Ser Arg 
                165     


<210>  4
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Glu Pro Pro Ala Pro Gly Asn Ala Ser 
    130                 135                 140                 


Glu Ser Glu Glu Asp Arg Ser Ala Gly Ser Val Glu Ser Pro Ser Val 
145                 150                 155                 160 


Ser Ser Thr His Arg Val Ser Asp Pro Lys Phe His Pro Leu His Ser 
                165                 170                 175     


Lys Ile Ile Ile Ile Lys Lys Gly His Ala Lys Asp Ser Gln Arg Tyr 
            180                 185                 190         


Lys Val Asp Tyr Glu Ser Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser 
        195                 200                 205             


Glu Ser Lys Arg Glu Thr Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu 
    210                 215                 220                 


Asp Thr Leu Asn His Leu Lys Phe Leu Asn Val Leu Ser Pro Arg Gly 
225                 230                 235                 240 


Val His Ile Pro Asn Cys Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln 
                245                 250                 255     


Cys Arg Pro Ser Lys Gly Arg Lys Arg Gly Phe Cys Trp Cys Val Asp 
            260                 265                 270         


Lys Tyr Gly Gln Pro Leu Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp 
        275                 280                 285             


Val His Cys Tyr Ser Met Gln Ser Lys 
    290                 295         


