                         SEQUENCE LISTING

<110>  Laboratorios del Dr. ESTEVE S. A.
       Universitat Autnoma de Barcelona
 
<120>  ADENOASSOCIATED VIRUS VECTORS FOR THE TREATMENT OF 
       MUCOPOLYSACCHARIDOSES

<130>  PCT2212.6

<150>  EP15382297
<151>  2015-06-05

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210>  2
<211>  1653
<212>  DNA
<213>  Homo sapiens

<400>  2
atgccgccac cccggaccgg ccgaggcctt ctctggctgg gtctggttct gagctccgtc       60

tgcgtcgccc tcggatccga aacgcaggcc aactcgacca cagatgctct gaacgttctt      120

ctcatcatcg tggatgacct gcgcccctcc ctgggctgtt atggggataa gctggtgagg      180

tccccaaata ttgaccaact ggcatcccac agcctcctct tccagaatgc ctttgcgcag      240

caagcagtgt gcgccccgag ccgcgtttct ttcctcactg gcaggagacc tgacaccacc      300

cgcctgtacg acttcaactc ctactggagg gtgcacgctg gaaacttctc caccatcccc      360

cagtacttca aggagaatgg ctatgtgacc atgtcggtgg gaaaagtctt tcaccctggg      420

atatcttcta accataccga tgattctccg tatagctggt cttttccacc ttatcatcct      480

tcctctgaga agtatgaaaa cactaagaca tgtcgagggc cagatggaga actccatgcc      540

aacctgcttt gccctgtgga tgtgctggat gttcccgagg gcaccttgcc tgacaaacag      600

agcactgagc aagccataca gttgttggaa aagatgaaaa cgtcagccag tcctttcttc      660

ctggccgttg ggtatcataa gccacacatc cccttcagat accccaagga atttcagaag      720

ttgtatccct tggagaacat caccctggcc cccgatcccg aggtccctga tggcctaccc      780

cctgtggcct acaacccctg gatggacatc aggcaacggg aagacgtcca agccttaaac      840

atcagtgtgc cgtatggtcc aattcctgtg gactttcagc ggaaaatccg ccagagctac      900

tttgcctctg tgtcatattt ggatacacag gtcggccgcc tcttgagtgc tttggacgat      960

cttcagctgg ccaacagcac catcattgca tttacctcgg atcatgggtg ggctctaggt     1020

gaacatggag aatgggccaa atacagcaat tttgatgttg ctacccatgt tcccctgata     1080

ttctatgttc ctggaaggac ggcttcactt ccggaggcag gcgagaagct tttcccttac     1140

ctcgaccctt ttgattccgc ctcacagttg atggagccag gcaggcaatc catggacctt     1200

gtggaacttg tgtctctttt tcccacgctg gctggacttg caggactgca ggttccacct     1260

cgctgccccg ttccttcatt tcacgttgag ctgtgcagag aaggcaagaa ccttctgaag     1320

cattttcgat tccgtgactt ggaagaggat ccgtacctcc ctggtaatcc ccgtgaactg     1380

attgcctata gccagtatcc ccggccttca gacatccctc agtggaattc tgacaagccg     1440

agtttaaaag atataaagat catgggctat tccatacgca ccatagacta taggtatact     1500

gtgtgggttg gcttcaatcc tgatgaattt ctagctaact tttctgacat ccatgcaggg     1560

gaactgtatt ttgtggattc tgacccattg caggatcaca atatgtataa tgattcccaa     1620

ggtggagatc ttttccagtt gttgatgcct tga                                  1653


<210>  3
<211>  7900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-hIDS

<400>  3
aaatacgcgt atgccgccac cccggaccgg ccgaggcctt ctctggctgg gtctggttct       60

gagctccgtc tgcgtcgccc tcggatccga aacgcaggcc aactcgacca cagatgctct      120

gaacgttctt ctcatcatcg tggatgacct gcgcccctcc ctgggctgtt atggggataa      180

gctggtgagg tccccaaata ttgaccaact ggcatcccac agcctcctct tccagaatgc      240

ctttgcgcag caagcagtgt gcgccccgag ccgcgtttct ttcctcactg gcaggagacc      300

tgacaccacc cgcctgtacg acttcaactc ctactggagg gtgcacgctg gaaacttctc      360

caccatcccc cagtacttca aggagaatgg ctatgtgacc atgtcggtgg gaaaagtctt      420

tcaccctggg atatcttcta accataccga tgattctccg tatagctggt cttttccacc      480

ttatcatcct tcctctgaga agtatgaaaa cactaagaca tgtcgagggc cagatggaga      540

actccatgcc aacctgcttt gccctgtgga tgtgctggat gttcccgagg gcaccttgcc      600

tgacaaacag agcactgagc aagccataca gttgttggaa aagatgaaaa cgtcagccag      660

tcctttcttc ctggccgttg ggtatcataa gccacacatc cccttcagat accccaagga      720

atttcagaag ttgtatccct tggagaacat caccctggcc cccgatcccg aggtccctga      780

tggcctaccc cctgtggcct acaacccctg gatggacatc aggcaacggg aagacgtcca      840

agccttaaac atcagtgtgc cgtatggtcc aattcctgtg gactttcagc ggaaaatccg      900

ccagagctac tttgcctctg tgtcatattt ggatacacag gtcggccgcc tcttgagtgc      960

tttggacgat cttcagctgg ccaacagcac catcattgca tttacctcgg atcatgggtg     1020

ggctctaggt gaacatggag aatgggccaa atacagcaat tttgatgttg ctacccatgt     1080

tcccctgata ttctatgttc ctggaaggac ggcttcactt ccggaggcag gcgagaagct     1140

tttcccttac ctcgaccctt ttgattccgc ctcacagttg atggagccag gcaggcaatc     1200

catggacctt gtggaacttg tgtctctttt tcccacgctg gctggacttg caggactgca     1260

ggttccacct cgctgccccg ttccttcatt tcacgttgag ctgtgcagag aaggcaagaa     1320

ccttctgaag cattttcgat tccgtgactt ggaagaggat ccgtacctcc ctggtaatcc     1380

ccgtgaactg attgcctata gccagtatcc ccggccttca gacatccctc agtggaattc     1440

tgacaagccg agtttaaaag atataaagat catgggctat tccatacgca ccatagacta     1500

taggtatact gtgtgggttg gcttcaatcc tgatgaattt ctagctaact tttctgacat     1560

ccatgcaggg gaactgtatt ttgtggattc tgacccattg caggatcaca atatgtataa     1620

tgattcccaa ggtggagatc ttttccagtt gttgatgcct tgagaattca tttaattcga     1680

gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc tgcctatcag aaggtggtgg     1740

ctggtgtggc caatgccctg gctcacaaat accactgaga tctttttccc tctgccaaaa     1800

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     1860

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagg acatatggga     1920

gggcaaatca tttaaaacat cagaatgagt atttggttta gagtttggca acatatgccc     1980

atatgctggc tgccatgaac aaaggttggc tataaagagg tcatcagtat atgaaacagc     2040

cccctgctgt ccattcctta ttccatagaa aagccttgac ttgaggttag atttttttta     2100

tattttgttt tgtgttattt ttttctttaa catccctaaa attttcctta catgttttac     2160

tagccagatt tttcctcctc tcctgactac tcccagtcat agctgtccct cttctcttat     2220

ggagatccct cgacctgcag cccaagctgt agataagtag catggcgggt taatcattaa     2280

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     2340

tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcatt     2400

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     2460

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     2520

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     2580

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     2640

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     2700

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     2760

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     2820

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     2880

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     2940

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     3000

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     3060

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     3120

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     3180

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     3240

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     3300

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     3360

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     3420

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     3480

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     3540

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     3600

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     3660

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     3720

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     3780

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     3840

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     3900

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     3960

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     4020

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     4080

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     4140

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     4200

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     4260

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     4320

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     4380

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     4440

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     4500

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     4560

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     4620

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     4680

tcaggcgatt ccaacatcca ataaatcata caggcaaggc aaagaattag caaaattaag     4740

caataaagcc tcagagcata aagctaaatc ggttgtacca aaaacattat gaccctgtaa     4800

tacttttgcg ggagaagcct ttatttcaac gcaaggataa aaatttttag aaccctcata     4860

tattttaaat gcaatgcctg agtaatgtgt aggtaaagat tcaaacgggt gagaaaggcc     4920

ggagacagtc aaatcaccat caatatgata ttcaaccgtt ctagctgata aattcatgcc     4980

ggagagggta gctatttttg agaggtctct acaaaggcta tcaggtcatt gcctgagagt     5040

ctggagcaaa caagagaatc gatgaacggt aatcgtaaaa ctagcatgtc aatcatatgt     5100

accccggttg ataatcagaa aagccccaaa aacaggaaga ttgtataagc aaatatttaa     5160

attgtaagcg ttaatatttt gttaaaattc gcgttaaatt tttgttaaat cagctcattt     5220

tttaaccaat aggccgaaat cggcaaaatc ccttataaat caaaagaata gaccgagata     5280

gggttgagtg ttgttccagt ttggaacaag agtccactat taaagaacgt ggactccaac     5340

gtcaaagggc gaaaaaccgt ctatcagggc gatggcccac tacgtgaacc atcaccctaa     5400

tcaagttttt tggggtcgag gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc     5460

cgatttagag cttgacgggg aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg     5520

aaaggagcgg gcgctagggc gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca     5580

cccgccgcgc ttaatgcgcc gctacagggc gcgtactatg gttgctttga cgagcacgta     5640

taacgtgctt tcctcgttag aatcagagcg ggagctaaac aggaggccga ttaaagggat     5700

tttagacagg aacggtacgc cagaatcctg agaagtgttt ttataatcag tgaggccacc     5760

gagtaaaaga gtctgtccat cacgcaaatt aaccgttgtc gcaatacttc tttgattagt     5820

aataacatca cttgcctgag tagaagaact caaactatcg gccttgctgg taatatccag     5880

aacaatatta ccgccagcca ttgcaacgga atcgccattc gccattcagg ctgcgcaact     5940

gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccagctgcgc gctcgctcgc     6000

tcactgaggc cgcccgggca aagcccgggc gtcgggcgac ctttggtcgc ccggcctcag     6060

tgagcgagcg agcgcgcaga gagggagtgg ccaactccat cactaggggt tccttgtagt     6120

taatgattaa cccgccatgc tacttatcta ctcgacattg attattgact agttattaat     6180

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac     6240

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa     6300

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt     6360

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc     6420

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat     6480

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg     6540

tgagccccac gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt     6600

atttatttat tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg     6660

cgccaggcgg ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg     6720

cagccaatca gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc     6780

ggccctataa aaagcgaagc gcgcggcggg cgggagtcgc tgcgttgcct tcgccccgtg     6840

ccccgctccg ccgccgcctc gcgccgcccg ccccggctct gactgaccgc gttactccca     6900

caggtgagcg ggcgggacgg cccttctcct ccgggctgta attagcgctt ggtttaatga     6960

cggcttgttt cttttctgtg gctgcgtgaa agccttgagg ggctccggga gggccctttg     7020

tgcgggggga gcggctcggg gggtgcgtgc gtgtgtgtgt gcgtggggag cgccgcgtgc     7080

ggctccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg gcgcggggct ttgtgcgctc     7140

cgcagtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg ggggggctgc     7200

gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg ggtgagcagg gggtgtgggc     7260

gcgtcggtcg ggctgcaacc ccccctgcac ccccctcccc gagttgctga gcacggcccg     7320

gcttcgggtg cggggctccg tacggggcgt ggcgcggggc tcgccgtgcc gggcgggggg     7380

tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg     7440

gaggggcgcg gcggcccccg gagcgccggc ggctgtcgag gcgcggcgag ccgcagccat     7500

tgccttttat ggtaatcgtg cgagagggcg cagggacttc ctttgtccca aatctgtgcg     7560

gagccgaaat ctgggaggcg ccgccgcacc ccctctagcg ggcgcggggc gaagcggtgc     7620

ggcgccggca ggaaggaaat gggcggggag ggccttcgtg cgtcgccgcg ccgccgtccc     7680

cttctccctc tccagcctcg gggctgtccg cggggggacg gctgccttcg ggggggacgg     7740

ggcagggcgg ggttcggctt ctggcgtgtg accggcggct ctagagcctc tgctaaccat     7800

gttcatgcct tcttcttttt cctacagctc ctgggcaacg tgctggttat tgtgctgtct     7860

catcattttg gcaaagaatt gattaattcg agcgaacgcg                           7900


<210>  4
<211>  4319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-hIDS

<400>  4
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgaaat acgcgtatgc cgccaccccg gaccggccga ggccttctct ggctgggtct     1980

ggttctgagc tccgtctgcg tcgccctcgg atccgaaacg caggccaact cgaccacaga     2040

tgctctgaac gttcttctca tcatcgtgga tgacctgcgc ccctccctgg gctgttatgg     2100

ggataagctg gtgaggtccc caaatattga ccaactggca tcccacagcc tcctcttcca     2160

gaatgccttt gcgcagcaag cagtgtgcgc cccgagccgc gtttctttcc tcactggcag     2220

gagacctgac accacccgcc tgtacgactt caactcctac tggagggtgc acgctggaaa     2280

cttctccacc atcccccagt acttcaagga gaatggctat gtgaccatgt cggtgggaaa     2340

agtctttcac cctgggatat cttctaacca taccgatgat tctccgtata gctggtcttt     2400

tccaccttat catccttcct ctgagaagta tgaaaacact aagacatgtc gagggccaga     2460

tggagaactc catgccaacc tgctttgccc tgtggatgtg ctggatgttc ccgagggcac     2520

cttgcctgac aaacagagca ctgagcaagc catacagttg ttggaaaaga tgaaaacgtc     2580

agccagtcct ttcttcctgg ccgttgggta tcataagcca cacatcccct tcagataccc     2640

caaggaattt cagaagttgt atcccttgga gaacatcacc ctggcccccg atcccgaggt     2700

ccctgatggc ctaccccctg tggcctacaa cccctggatg gacatcaggc aacgggaaga     2760

cgtccaagcc ttaaacatca gtgtgccgta tggtccaatt cctgtggact ttcagcggaa     2820

aatccgccag agctactttg cctctgtgtc atatttggat acacaggtcg gccgcctctt     2880

gagtgctttg gacgatcttc agctggccaa cagcaccatc attgcattta cctcggatca     2940

tgggtgggct ctaggtgaac atggagaatg ggccaaatac agcaattttg atgttgctac     3000

ccatgttccc ctgatattct atgttcctgg aaggacggct tcacttccgg aggcaggcga     3060

gaagcttttc ccttacctcg acccttttga ttccgcctca cagttgatgg agccaggcag     3120

gcaatccatg gaccttgtgg aacttgtgtc tctttttccc acgctggctg gacttgcagg     3180

actgcaggtt ccacctcgct gccccgttcc ttcatttcac gttgagctgt gcagagaagg     3240

caagaacctt ctgaagcatt ttcgattccg tgacttggaa gaggatccgt acctccctgg     3300

taatccccgt gaactgattg cctatagcca gtatccccgg ccttcagaca tccctcagtg     3360

gaattctgac aagccgagtt taaaagatat aaagatcatg ggctattcca tacgcaccat     3420

agactatagg tatactgtgt gggttggctt caatcctgat gaatttctag ctaacttttc     3480

tgacatccat gcaggggaac tgtattttgt ggattctgac ccattgcagg atcacaatat     3540

gtataatgat tcccaaggtg gagatctttt ccagttgttg atgccttgag aattcattta     3600

attcgagctc ggtacccggg aatcaattca ctcctcaggt gcaggctgcc tatcagaagg     3660

tggtggctgg tgtggccaat gccctggctc acaaatacca ctgagatctt tttccctctg     3720

ccaaaaatta tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga     3780

aatttatttt cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat     3840

atgggagggc aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat     3900

atgcccatat gctggctgcc atgaacaaag gttggctata aagaggtcat cagtatatga     3960

aacagccccc tgctgtccat tccttattcc atagaaaagc cttgacttga ggttagattt     4020

tttttatatt ttgttttgtg ttattttttt ctttaacatc cctaaaattt tccttacatg     4080

ttttactagc cagatttttc ctcctctcct gactactccc agtcatagct gtccctcttc     4140

tcttatggag atccctcgac ctgcagccca agctgtagat aagtagcatg gcgggttaat     4200

cattaactac aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc     4260

gctcactgag gccgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag      4319


<210>  5
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohIDS-version1

<400>  5
atgcccccac ctagaaccgg aagaggattg ctctggctcg gacttgtgct gtccagcgtg       60

tgtgtggccc tgggctcgga aacccaggcc aacagcacca ccgacgccct gaatgtgctg      120

ctgattatcg tggacgatct ccggccttcg ctgggctgct acggggataa gctggtccgc      180

tccccgaata tcgaccaact ggcttcacat agcctgcttt tccaaaacgc attcgcccaa      240

caagccgtgt gcgccccgag ccgcgtgtct ttcctcaccg gccggcgccc tgatactacc      300

cggctctacg acttcaacag ctactggaga gtgcacgcag gaaacttctc caccattcct      360

cagtacttta aggagaacgg ttacgtcacc atgagcgtgg ggaaggtgtt ccaccctgga      420

atttcctcca accacaccga cgactcgcca tactcctggt cctttccccc ttaccaccca      480

tcatccgaga agtacgagaa caccaagacg tgcaggggcc cagacgggga actgcacgcg      540

aacctcctct gcccggtcga tgtgctggat gtgcccgaag gcaccctccc tgacaaacag      600

agcaccgaac aggccatcca gctcctcgag aagatgaaaa cttcagcctc cccgttcttt      660

ctggccgtgg gataccacaa gccgcatatc cccttccggt acccaaagga gttccagaag      720

ctgtacccgc tggagaacat taccctggct cctgatcccg aagtgccgga cggcctgccg      780

cccgtggcat acaacccttg gatggacatc cgccagaggg aggatgtgca agccctgaac      840

atctccgtgc catacggtcc gatcccggtc gacttccagc ggaagattag gcagtcatat      900

ttcgcgtccg tgtcctactt ggacactcag gtcggacgcc tcctctccgc tctcgacgat      960

ctgcagctgg ccaactcgac cattatcgcg ttcacctcgg accatggttg ggctctgggc     1020

gaacacggag aatgggccaa gtacagcaat ttcgatgtcg cgactcacgt gcccctgatc     1080

ttctacgtgc ccggacgcac agccagcttg cctgaagcgg gggaaaagct gttcccttac     1140

ctggatccct tcgactccgc ctctcaactt atggagccag gcagacagtc gatggacctg     1200

gtggaactcg tgtcactgtt ccctaccctc gccggtctgg ccggacttca ggtcccgcct     1260

cggtgcccgg tgccgtcctt ccacgtggag ctgtgtcgcg agggaaagaa cctcctgaaa     1320

cacttccggt tccgcgacct ggaggaagat ccctacttgc cgggcaaccc gagagaactt     1380

atcgcatact cccagtaccc tcgcccctcc gacatcccgc agtggaactc cgacaagccg     1440

agcctgaagg acattaagat catggggtac tccatccgga ctattgacta tcggtacact     1500

gtgtgggtcg ggttcaaccc agatgagttt ctggccaact tctccgatat ccatgccgga     1560

gagctgtact tcgtggactc ggacccgctg caggaccaca acatgtacaa cgactcacag     1620

ggcggcgacc tgttccagtt gctgatgccc tga                                  1653


<210>  6
<211>  7888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-ohIDS-version1

<400>  6
cgcgtgccac catgccccca cctagaaccg gaagaggatt gctctggctc ggacttgtgc       60

tgtccagcgt gtgtgtggcc ctgggctcgg aaacccaggc caacagcacc accgacgccc      120

tgaatgtgct gctgattatc gtggacgatc tccggccttc gctgggctgc tacggggata      180

agctggtccg ctccccgaat atcgaccaac tggcttcaca tagcctgctt ttccaaaacg      240

cattcgccca acaagccgtg tgcgccccga gccgcgtgtc tttcctcacc ggccggcgcc      300

ctgatactac ccggctctac gacttcaaca gctactggag agtgcacgca ggaaacttct      360

ccaccattcc tcagtacttt aaggagaacg gttacgtcac catgagcgtg gggaaggtgt      420

tccaccctgg aatttcctcc aaccacaccg acgactcgcc atactcctgg tcctttcccc      480

cttaccaccc atcatccgag aagtacgaga acaccaagac gtgcaggggc ccagacgggg      540

aactgcacgc gaacctcctc tgcccggtcg atgtgctgga tgtgcccgaa ggcaccctcc      600

ctgacaaaca gagcaccgaa caggccatcc agctcctcga gaagatgaaa acttcagcct      660

ccccgttctt tctggccgtg ggataccaca agccgcatat ccccttccgg tacccaaagg      720

agttccagaa gctgtacccg ctggagaaca ttaccctggc tcctgatccc gaagtgccgg      780

acggcctgcc gcccgtggca tacaaccctt ggatggacat ccgccagagg gaggatgtgc      840

aagccctgaa catctccgtg ccatacggtc cgatcccggt cgacttccag cggaagatta      900

ggcagtcata tttcgcgtcc gtgtcctact tggacactca ggtcggacgc ctcctctccg      960

ctctcgacga tctgcagctg gccaactcga ccattatcgc gttcacctcg gaccatggtt     1020

gggctctggg cgaacacgga gaatgggcca agtacagcaa tttcgatgtc gcgactcacg     1080

tgcccctgat cttctacgtg cccggacgca cagccagctt gcctgaagcg ggggaaaagc     1140

tgttccctta cctggatccc ttcgactccg cctctcaact tatggagcca ggcagacagt     1200

cgatggacct ggtggaactc gtgtcactgt tccctaccct cgccggtctg gccggacttc     1260

aggtcccgcc tcggtgcccg gtgccgtcct tccacgtgga gctgtgtcgc gagggaaaga     1320

acctcctgaa acacttccgg ttccgcgacc tggaggaaga tccctacttg ccgggcaacc     1380

cgagagaact tatcgcatac tcccagtacc ctcgcccctc cgacatcccg cagtggaact     1440

ccgacaagcc gagcctgaag gacattaaga tcatggggta ctccatccgg actattgact     1500

atcggtacac tgtgtgggtc gggttcaacc cagatgagtt tctggccaac ttctccgata     1560

tccatgccgg agagctgtac ttcgtggact cggacccgct gcaggaccac aacatgtaca     1620

acgactcaca gggcggcgac ctgttccagt tgctgatgcc ctgagaattc gagctcggta     1680

cccgggaatc aattcactcc tcaggtgcag gctgcctatc agaaggtggt ggctggtgtg     1740

gccaatgccc tggctcacaa ataccactga gatctttttc cctctgccaa aaattatggg     1800

gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt tattttcatt     1860

gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg gagggcaaat     1920

catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc ccatatgctg     1980

gctgccatga acaaaggttg gctataaaga ggtcatcagt atatgaaaca gccccctgct     2040

gtccattcct tattccatag aaaagccttg acttgaggtt agattttttt tatattttgt     2100

tttgtgttat ttttttcttt aacatcccta aaattttcct tacatgtttt actagccaga     2160

tttttcctcc tctcctgact actcccagtc atagctgtcc ctcttctctt atggagatcc     2220

ctcgacctgc agcccaagct gtagataagt agcatggcgg gttaatcatt aactacaagg     2280

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     2340

cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagctgca ttaatgaatc     2400

ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact     2460

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     2520

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     2580

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     2640

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     2700

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     2760

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     2820

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     2880

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     2940

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     3000

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     3060

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     3120

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     3180

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     3240

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     3300

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     3360

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     3420

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     3480

gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct     3540

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     3600

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     3660

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg     3720

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     3780

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     3840

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     3900

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     3960

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     4020

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     4080

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     4140

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca     4200

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat     4260

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag     4320

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtctaa     4380

gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt     4440

ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc     4500

acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt     4560

gttggcgggt gtcggggctg gcttaactat gcggcatcag agcagattgt actgagagtg     4620

caccatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcga     4680

ttccaacatc caataaatca tacaggcaag gcaaagaatt agcaaaatta agcaataaag     4740

cctcagagca taaagctaaa tcggttgtac caaaaacatt atgaccctgt aatacttttg     4800

cgggagaagc ctttatttca acgcaaggat aaaaattttt agaaccctca tatattttaa     4860

atgcaatgcc tgagtaatgt gtaggtaaag attcaaacgg gtgagaaagg ccggagacag     4920

tcaaatcacc atcaatatga tattcaaccg ttctagctga taaattcatg ccggagaggg     4980

tagctatttt tgagaggtct ctacaaaggc tatcaggtca ttgcctgaga gtctggagca     5040

aacaagagaa tcgatgaacg gtaatcgtaa aactagcatg tcaatcatat gtaccccggt     5100

tgataatcag aaaagcccca aaaacaggaa gattgtataa gcaaatattt aaattgtaag     5160

cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca     5220

ataggccgaa atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag     5280

tgttgttcca gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg     5340

gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt     5400

tttggggtcg aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag     5460

agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc     5520

gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc     5580

gcttaatgcg ccgctacagg gcgcgtacta tggttgcttt gacgagcacg tataacgtgc     5640

tttcctcgtt agaatcagag cgggagctaa acaggaggcc gattaaaggg attttagaca     5700

ggaacggtac gccagaatcc tgagaagtgt ttttataatc agtgaggcca ccgagtaaaa     5760

gagtctgtcc atcacgcaaa ttaaccgttg tcgcaatact tctttgatta gtaataacat     5820

cacttgcctg agtagaagaa ctcaaactat cggccttgct ggtaatatcc agaacaatat     5880

taccgccagc cattgcaacg gaatcgccat tcgccattca ggctgcgcaa ctgttgggaa     5940

gggcgatcgg tgcgggcctc ttcgctatta cgccagctgc gcgctcgctc gctcactgag     6000

gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag     6060

cgagcgcgca gagagggagt ggccaactcc atcactaggg gttccttgta gttaatgatt     6120

aacccgccat gctacttatc tactcgacat tgattattga ctagttatta atagtaatca     6180

attacggggt cattagttca tagcccatat atggagttcc gcgttacata acttacggta     6240

aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat     6300

gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg     6360

taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac     6420

gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt     6480

cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga ggtgagcccc     6540

acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt     6600

attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggggcg cgcgccaggc     6660

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat     6720

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat     6780

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc     6840

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag     6900

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     6960

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     7020

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     7080

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     7140

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     7200

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     7260

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     7320

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     7380

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     7440

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     7500

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     7560

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     7620

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     7680

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     7740

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     7800

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     7860

tggcaaagaa ttgattaatt cgagcgaa                                        7888


<210>  7
<211>  4307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-ohIDS-version1

<400>  7
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgcccc cacctagaac cggaagagga ttgctctggc tcggacttgt     1980

gctgtccagc gtgtgtgtgg ccctgggctc ggaaacccag gccaacagca ccaccgacgc     2040

cctgaatgtg ctgctgatta tcgtggacga tctccggcct tcgctgggct gctacgggga     2100

taagctggtc cgctccccga atatcgacca actggcttca catagcctgc ttttccaaaa     2160

cgcattcgcc caacaagccg tgtgcgcccc gagccgcgtg tctttcctca ccggccggcg     2220

ccctgatact acccggctct acgacttcaa cagctactgg agagtgcacg caggaaactt     2280

ctccaccatt cctcagtact ttaaggagaa cggttacgtc accatgagcg tggggaaggt     2340

gttccaccct ggaatttcct ccaaccacac cgacgactcg ccatactcct ggtcctttcc     2400

cccttaccac ccatcatccg agaagtacga gaacaccaag acgtgcaggg gcccagacgg     2460

ggaactgcac gcgaacctcc tctgcccggt cgatgtgctg gatgtgcccg aaggcaccct     2520

ccctgacaaa cagagcaccg aacaggccat ccagctcctc gagaagatga aaacttcagc     2580

ctccccgttc tttctggccg tgggatacca caagccgcat atccccttcc ggtacccaaa     2640

ggagttccag aagctgtacc cgctggagaa cattaccctg gctcctgatc ccgaagtgcc     2700

ggacggcctg ccgcccgtgg catacaaccc ttggatggac atccgccaga gggaggatgt     2760

gcaagccctg aacatctccg tgccatacgg tccgatcccg gtcgacttcc agcggaagat     2820

taggcagtca tatttcgcgt ccgtgtccta cttggacact caggtcggac gcctcctctc     2880

cgctctcgac gatctgcagc tggccaactc gaccattatc gcgttcacct cggaccatgg     2940

ttgggctctg ggcgaacacg gagaatgggc caagtacagc aatttcgatg tcgcgactca     3000

cgtgcccctg atcttctacg tgcccggacg cacagccagc ttgcctgaag cgggggaaaa     3060

gctgttccct tacctggatc ccttcgactc cgcctctcaa cttatggagc caggcagaca     3120

gtcgatggac ctggtggaac tcgtgtcact gttccctacc ctcgccggtc tggccggact     3180

tcaggtcccg cctcggtgcc cggtgccgtc cttccacgtg gagctgtgtc gcgagggaaa     3240

gaacctcctg aaacacttcc ggttccgcga cctggaggaa gatccctact tgccgggcaa     3300

cccgagagaa cttatcgcat actcccagta ccctcgcccc tccgacatcc cgcagtggaa     3360

ctccgacaag ccgagcctga aggacattaa gatcatgggg tactccatcc ggactattga     3420

ctatcggtac actgtgtggg tcgggttcaa cccagatgag tttctggcca acttctccga     3480

tatccatgcc ggagagctgt acttcgtgga ctcggacccg ctgcaggacc acaacatgta     3540

caacgactca cagggcggcg acctgttcca gttgctgatg ccctgagaat tcgagctcgg     3600

tacccgggaa tcaattcact cctcaggtgc aggctgccta tcagaaggtg gtggctggtg     3660

tggccaatgc cctggctcac aaataccact gagatctttt tccctctgcc aaaaattatg     3720

gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca     3780

ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aaggacatat gggagggcaa     3840

atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc     3900

tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg     3960

ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt     4020

gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca     4080

gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat     4140

ccctcgacct gcagcccaag ctgtagataa gtagcatggc gggttaatca ttaactacaa     4200

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4260

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcag                   4307


<210>  8
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ohIDS-version2

<400>  8
atgcctcctc ctagaactgg aagggggctg ctgtggctgg ggctggtcct gtcatcagtg       60

tgtgtcgctc tgggctccga gactcaggca aactccacca cagacgccct gaatgtgctg      120

ctgatcattg tcgacgatct gcgaccttcc ctggggtgct acggcgacaa gctggtgagg      180

tctccaaaca tcgatcagct ggcttcacac agcctgctgt tccagaatgc ctttgctcag      240

caggcagtgt gtgcaccatc acgggtcagc ttcctgaccg gaaggagacc tgacactacc      300

aggctgtacg attttaactc atattggaga gtgcatgccg ggaatttcag caccatccca      360

cagtacttta aggagaacgg ctatgtgaca atgtccgtgg gaaaagtctt ccaccccggc      420

attagctcca atcatacaga cgattctcca tactcctggt cttttccccc ttatcacccc      480

tctagtgaga agtacgaaaa cacaaaaact tgcaggggac cagacgggga gctgcatgca      540

aatctgctgt gtcccgtgga cgtcctggat gtgcccgaag gcacactgcc tgataagcag      600

agcactgagc aggccattca gctgctggaa aagatgaaaa caagtgcttc acccttcttt      660

ctggcagtgg gatatcacaa accacatatc cccttcagat atcccaagga gtttcagaaa      720

ctgtaccctc tggaaaacat tactctggct cccgaccctg aggtgcctga tggactgcca      780

cccgtcgcat ataacccatg gatggacatc cggcagcgcg aggatgtgca ggccctgaat      840

atcagtgtcc cttacgggcc aattcccgtg gacttccaga gaaagattcg gcagtcttac      900

tttgccagcg tctcctatct ggatactcaa gtgggacgac tgctgagcgc tctggacgat      960

ctgcagctgg ccaacagcac catcattgct ttcacatccg accacggatg ggctctggga     1020

gagcatggag aatgggcaaa gtatagcaat ttcgatgtgg ccactcacgt cccactgatc     1080

ttttacgtgc ccggccgaac cgcatccctg ccagaggctg gagaaaaact gttcccttac     1140

ctggacccat ttgattctgc tagtcagctg atggagcctg gccgacagtc tatggacctg     1200

gtggaactgg tcagtctgtt ccctacactg gctggactgg caggactgca ggtgcctcca     1260

agatgccctg tgccatcttt tcacgtcgag ctgtgtcggg aaggcaagaa cctgctgaaa     1320

catttcaggt tcagggacct ggaggaagat ccttatctgc caggaaatcc cagggagctg     1380

atcgcctaca gtcagtatcc ccgcccttca gacattcctc agtggaactc cgacaagcca     1440

tctctgaagg atatcaaaat tatgggatac agcatccgca ctattgatta ccgatatacc     1500

gtgtgggtcg ggttcaaccc cgacgagttc ctggcaaatt ttagtgatat ccacgccggc     1560

gaactgtatt ttgtggactc agatcctctg caggaccata acatgtacaa tgacagccag     1620

ggcggagatc tgttccagct gctgatgcca tga                                  1653


<210>  9
<211>  7888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-ohIDS-version2

<400>  9
cgcgtgccac catgcctcct cctagaactg gaagggggct gctgtggctg gggctggtcc       60

tgtcatcagt gtgtgtcgct ctgggctccg agactcaggc aaactccacc acagacgccc      120

tgaatgtgct gctgatcatt gtcgacgatc tgcgaccttc cctggggtgc tacggcgaca      180

agctggtgag gtctccaaac atcgatcagc tggcttcaca cagcctgctg ttccagaatg      240

cctttgctca gcaggcagtg tgtgcaccat cacgggtcag cttcctgacc ggaaggagac      300

ctgacactac caggctgtac gattttaact catattggag agtgcatgcc gggaatttca      360

gcaccatccc acagtacttt aaggagaacg gctatgtgac aatgtccgtg ggaaaagtct      420

tccaccccgg cattagctcc aatcatacag acgattctcc atactcctgg tcttttcccc      480

cttatcaccc ctctagtgag aagtacgaaa acacaaaaac ttgcagggga ccagacgggg      540

agctgcatgc aaatctgctg tgtcccgtgg acgtcctgga tgtgcccgaa ggcacactgc      600

ctgataagca gagcactgag caggccattc agctgctgga aaagatgaaa acaagtgctt      660

cacccttctt tctggcagtg ggatatcaca aaccacatat ccccttcaga tatcccaagg      720

agtttcagaa actgtaccct ctggaaaaca ttactctggc tcccgaccct gaggtgcctg      780

atggactgcc acccgtcgca tataacccat ggatggacat ccggcagcgc gaggatgtgc      840

aggccctgaa tatcagtgtc ccttacgggc caattcccgt ggacttccag agaaagattc      900

ggcagtctta ctttgccagc gtctcctatc tggatactca agtgggacga ctgctgagcg      960

ctctggacga tctgcagctg gccaacagca ccatcattgc tttcacatcc gaccacggat     1020

gggctctggg agagcatgga gaatgggcaa agtatagcaa tttcgatgtg gccactcacg     1080

tcccactgat cttttacgtg cccggccgaa ccgcatccct gccagaggct ggagaaaaac     1140

tgttccctta cctggaccca tttgattctg ctagtcagct gatggagcct ggccgacagt     1200

ctatggacct ggtggaactg gtcagtctgt tccctacact ggctggactg gcaggactgc     1260

aggtgcctcc aagatgccct gtgccatctt ttcacgtcga gctgtgtcgg gaaggcaaga     1320

acctgctgaa acatttcagg ttcagggacc tggaggaaga tccttatctg ccaggaaatc     1380

ccagggagct gatcgcctac agtcagtatc cccgcccttc agacattcct cagtggaact     1440

ccgacaagcc atctctgaag gatatcaaaa ttatgggata cagcatccgc actattgatt     1500

accgatatac cgtgtgggtc gggttcaacc ccgacgagtt cctggcaaat tttagtgata     1560

tccacgccgg cgaactgtat tttgtggact cagatcctct gcaggaccat aacatgtaca     1620

atgacagcca gggcggagat ctgttccagc tgctgatgcc atgagaattc gagctcggta     1680

cccgggaatc aattcactcc tcaggtgcag gctgcctatc agaaggtggt ggctggtgtg     1740

gccaatgccc tggctcacaa ataccactga gatctttttc cctctgccaa aaattatggg     1800

gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt tattttcatt     1860

gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg gagggcaaat     1920

catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc ccatatgctg     1980

gctgccatga acaaaggttg gctataaaga ggtcatcagt atatgaaaca gccccctgct     2040

gtccattcct tattccatag aaaagccttg acttgaggtt agattttttt tatattttgt     2100

tttgtgttat ttttttcttt aacatcccta aaattttcct tacatgtttt actagccaga     2160

tttttcctcc tctcctgact actcccagtc atagctgtcc ctcttctctt atggagatcc     2220

ctcgacctgc agcccaagct gtagataagt agcatggcgg gttaatcatt aactacaagg     2280

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     2340

cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagctgca ttaatgaatc     2400

ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact     2460

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     2520

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     2580

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     2640

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     2700

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     2760

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     2820

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     2880

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     2940

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     3000

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     3060

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     3120

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     3180

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     3240

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     3300

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     3360

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     3420

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     3480

gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct     3540

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     3600

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     3660

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg     3720

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     3780

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     3840

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     3900

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     3960

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     4020

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     4080

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     4140

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca     4200

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat     4260

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag     4320

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtctaa     4380

gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt     4440

ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc     4500

acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt     4560

gttggcgggt gtcggggctg gcttaactat gcggcatcag agcagattgt actgagagtg     4620

caccatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcga     4680

ttccaacatc caataaatca tacaggcaag gcaaagaatt agcaaaatta agcaataaag     4740

cctcagagca taaagctaaa tcggttgtac caaaaacatt atgaccctgt aatacttttg     4800

cgggagaagc ctttatttca acgcaaggat aaaaattttt agaaccctca tatattttaa     4860

atgcaatgcc tgagtaatgt gtaggtaaag attcaaacgg gtgagaaagg ccggagacag     4920

tcaaatcacc atcaatatga tattcaaccg ttctagctga taaattcatg ccggagaggg     4980

tagctatttt tgagaggtct ctacaaaggc tatcaggtca ttgcctgaga gtctggagca     5040

aacaagagaa tcgatgaacg gtaatcgtaa aactagcatg tcaatcatat gtaccccggt     5100

tgataatcag aaaagcccca aaaacaggaa gattgtataa gcaaatattt aaattgtaag     5160

cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa atcagctcat tttttaacca     5220

ataggccgaa atcggcaaaa tcccttataa atcaaaagaa tagaccgaga tagggttgag     5280

tgttgttcca gtttggaaca agagtccact attaaagaac gtggactcca acgtcaaagg     5340

gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa ccatcaccct aatcaagttt     5400

tttggggtcg aggtgccgta aagcactaaa tcggaaccct aaagggagcc cccgatttag     5460

agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc     5520

gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc     5580

gcttaatgcg ccgctacagg gcgcgtacta tggttgcttt gacgagcacg tataacgtgc     5640

tttcctcgtt agaatcagag cgggagctaa acaggaggcc gattaaaggg attttagaca     5700

ggaacggtac gccagaatcc tgagaagtgt ttttataatc agtgaggcca ccgagtaaaa     5760

gagtctgtcc atcacgcaaa ttaaccgttg tcgcaatact tctttgatta gtaataacat     5820

cacttgcctg agtagaagaa ctcaaactat cggccttgct ggtaatatcc agaacaatat     5880

taccgccagc cattgcaacg gaatcgccat tcgccattca ggctgcgcaa ctgttgggaa     5940

gggcgatcgg tgcgggcctc ttcgctatta cgccagctgc gcgctcgctc gctcactgag     6000

gccgcccggg caaagcccgg gcgtcgggcg acctttggtc gcccggcctc agtgagcgag     6060

cgagcgcgca gagagggagt ggccaactcc atcactaggg gttccttgta gttaatgatt     6120

aacccgccat gctacttatc tactcgacat tgattattga ctagttatta atagtaatca     6180

attacggggt cattagttca tagcccatat atggagttcc gcgttacata acttacggta     6240

aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat     6300

gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg     6360

taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac     6420

gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt     6480

cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtcga ggtgagcccc     6540

acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt gtatttattt     6600

attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggggcg cgcgccaggc     6660

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat     6720

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat     6780

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc     6840

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag     6900

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     6960

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     7020

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     7080

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     7140

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     7200

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     7260

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     7320

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     7380

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     7440

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     7500

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     7560

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     7620

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     7680

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     7740

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     7800

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     7860

tggcaaagaa ttgattaatt cgagcgaa                                        7888


<210>  10
<211>  4307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-ohIDS-version2

<400>  10
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgcc accatgcctc ctcctagaac tggaaggggg ctgctgtggc tggggctggt     1980

cctgtcatca gtgtgtgtcg ctctgggctc cgagactcag gcaaactcca ccacagacgc     2040

cctgaatgtg ctgctgatca ttgtcgacga tctgcgacct tccctggggt gctacggcga     2100

caagctggtg aggtctccaa acatcgatca gctggcttca cacagcctgc tgttccagaa     2160

tgcctttgct cagcaggcag tgtgtgcacc atcacgggtc agcttcctga ccggaaggag     2220

acctgacact accaggctgt acgattttaa ctcatattgg agagtgcatg ccgggaattt     2280

cagcaccatc ccacagtact ttaaggagaa cggctatgtg acaatgtccg tgggaaaagt     2340

cttccacccc ggcattagct ccaatcatac agacgattct ccatactcct ggtcttttcc     2400

cccttatcac ccctctagtg agaagtacga aaacacaaaa acttgcaggg gaccagacgg     2460

ggagctgcat gcaaatctgc tgtgtcccgt ggacgtcctg gatgtgcccg aaggcacact     2520

gcctgataag cagagcactg agcaggccat tcagctgctg gaaaagatga aaacaagtgc     2580

ttcacccttc tttctggcag tgggatatca caaaccacat atccccttca gatatcccaa     2640

ggagtttcag aaactgtacc ctctggaaaa cattactctg gctcccgacc ctgaggtgcc     2700

tgatggactg ccacccgtcg catataaccc atggatggac atccggcagc gcgaggatgt     2760

gcaggccctg aatatcagtg tcccttacgg gccaattccc gtggacttcc agagaaagat     2820

tcggcagtct tactttgcca gcgtctccta tctggatact caagtgggac gactgctgag     2880

cgctctggac gatctgcagc tggccaacag caccatcatt gctttcacat ccgaccacgg     2940

atgggctctg ggagagcatg gagaatgggc aaagtatagc aatttcgatg tggccactca     3000

cgtcccactg atcttttacg tgcccggccg aaccgcatcc ctgccagagg ctggagaaaa     3060

actgttccct tacctggacc catttgattc tgctagtcag ctgatggagc ctggccgaca     3120

gtctatggac ctggtggaac tggtcagtct gttccctaca ctggctggac tggcaggact     3180

gcaggtgcct ccaagatgcc ctgtgccatc ttttcacgtc gagctgtgtc gggaaggcaa     3240

gaacctgctg aaacatttca ggttcaggga cctggaggaa gatccttatc tgccaggaaa     3300

tcccagggag ctgatcgcct acagtcagta tccccgccct tcagacattc ctcagtggaa     3360

ctccgacaag ccatctctga aggatatcaa aattatggga tacagcatcc gcactattga     3420

ttaccgatat accgtgtggg tcgggttcaa ccccgacgag ttcctggcaa attttagtga     3480

tatccacgcc ggcgaactgt attttgtgga ctcagatcct ctgcaggacc ataacatgta     3540

caatgacagc cagggcggag atctgttcca gctgctgatg ccatgagaat tcgagctcgg     3600

tacccgggaa tcaattcact cctcaggtgc aggctgccta tcagaaggtg gtggctggtg     3660

tggccaatgc cctggctcac aaataccact gagatctttt tccctctgcc aaaaattatg     3720

gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa tttattttca     3780

ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aaggacatat gggagggcaa     3840

atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat gcccatatgc     3900

tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa cagccccctg     3960

ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt tttatatttt     4020

gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt ttactagcca     4080

gatttttcct cctctcctga ctactcccag tcatagctgt ccctcttctc ttatggagat     4140

ccctcgacct gcagcccaag ctgtagataa gtagcatggc gggttaatca ttaactacaa     4200

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4260

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcag                   4307


<210>  11
<211>  1665
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  omIDS

<400>  11
atgagcccac ctcccccacc cccaatctgg cggcagctga gcttcagcct gctgctgggc       60

agcttctgta tcgccctgga aagcgccaag cttgcccagg gcaacagcgc caccgacgcc      120

ctgaacatcc tgctgatcat cgtggacgac ctgaggccca gcctgggatg ctacggcgac      180

aagctggtcc gcagccccaa catcgaccag ctggcttctc acagcgtgct gttccagaac      240

gcattcgcac agcaggccgt gtgcgccccc agcagagtgt ctttcctgac cggcagaagg      300

cccgacacca ccagactgta cgacttcaac agctactggc gggtgcacag cggcaacttc      360

agcaccatcc cccagtactt caaagaaaac ggctacgtga ccatgagcgt gggcaaggtg      420

ttccaccccg gcatcagcag caaccacagc gacgactacc cctacagctg gtccttccca      480

ccctaccacc ccagcagcga gaagtacgag aacaccaaga cctgcaaggg ccaggacggc      540

aagctgcacg ccaacctgct gtgccctgtg gacgtggcag acgtgccaga gggaaccctg      600

cctgacaagc agagcaccga ggaagccatc agactgctgg aaaagatgaa gaccagcgcc      660

agccccttct tcctggccgt gggctaccac aagccccaca tccctttcag ataccccaaa      720

gagttccaga agctgtaccc cctggaaaac atcaccctgg cccccgaccc ccacgtgcca      780

gattctctgc cccccgtggc ctacaacccc tggatggata tccgcgagcg cgaggacgtg      840

caggctctga acatcagcgt gccctacggc cctatccccg aggacttcca gagaaagatc      900

agacagagct acttcgccag cgtgtcctac ctggacaccc aagtgggaca cgtgctgagc      960

gccctggacg atctgagact ggcccacaac accatcattg ccttcaccag cgaccacggc     1020

tgggctctgg gagagcacgg cgagtgggcc aagtacagca acttcgacgt ggccaccaga     1080

gtgcccctga tgctgtacgt gcccggcaga accgcccctc tgcctgccgc tggacagaag     1140

ctgttccctt accgggaccc cttcgacccc gccagcgatt ggatggacgc cggcagacac     1200

accgaggacc tggtggaact ggtgtccctg ttccccaccc tggccggact ggctggactg     1260

cctgtgcccc ccagatgccc catccctagc ttccacgtcg aactgtgcag agagggccag     1320

aacctgcaga aacatctgca gctgcacgac ctggaagagg aacccgacct gttcggcaac     1380

cccagagagc tgatcgccta cagccagtac cccagacccg ccgacttccc ccagtggaac     1440

agcgacaagc ccagcctgaa cgacatcaaa gtgatgggct acagcatcag gaccgtggac     1500

tacagataca ccgtgtgggt cggattcgac cccagcgagt tcctggccaa cttcagcgac     1560

atccacgccg gcgagctgta cttcgtggac agcgaccccc tgcaggacca caacgtgtac     1620

aacgacagcc agcacggcgg cctgctgcac agcctgaggc cttga                     1665


<210>  12
<211>  7914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-CAG-omIDS

<400>  12
cgcgtgctag cgccaccatg agcccacctc ccccaccccc aatctggcgg cagctgagct       60

tcagcctgct gctgggcagc ttctgtatcg ccctggaaag cgccaagctt gcccagggca      120

acagcgccac cgacgccctg aacatcctgc tgatcatcgt ggacgacctg aggcccagcc      180

tgggatgcta cggcgacaag ctggtccgca gccccaacat cgaccagctg gcttctcaca      240

gcgtgctgtt ccagaacgca ttcgcacagc aggccgtgtg cgcccccagc agagtgtctt      300

tcctgaccgg cagaaggccc gacaccacca gactgtacga cttcaacagc tactggcggg      360

tgcacagcgg caacttcagc accatccccc agtacttcaa agaaaacggc tacgtgacca      420

tgagcgtggg caaggtgttc caccccggca tcagcagcaa ccacagcgac gactacccct      480

acagctggtc cttcccaccc taccacccca gcagcgagaa gtacgagaac accaagacct      540

gcaagggcca ggacggcaag ctgcacgcca acctgctgtg ccctgtggac gtggcagacg      600

tgccagaggg aaccctgcct gacaagcaga gcaccgagga agccatcaga ctgctggaaa      660

agatgaagac cagcgccagc cccttcttcc tggccgtggg ctaccacaag ccccacatcc      720

ctttcagata ccccaaagag ttccagaagc tgtaccccct ggaaaacatc accctggccc      780

ccgaccccca cgtgccagat tctctgcccc ccgtggccta caacccctgg atggatatcc      840

gcgagcgcga ggacgtgcag gctctgaaca tcagcgtgcc ctacggccct atccccgagg      900

acttccagag aaagatcaga cagagctact tcgccagcgt gtcctacctg gacacccaag      960

tgggacacgt gctgagcgcc ctggacgatc tgagactggc ccacaacacc atcattgcct     1020

tcaccagcga ccacggctgg gctctgggag agcacggcga gtgggccaag tacagcaact     1080

tcgacgtggc caccagagtg cccctgatgc tgtacgtgcc cggcagaacc gcccctctgc     1140

ctgccgctgg acagaagctg ttcccttacc gggacccctt cgaccccgcc agcgattgga     1200

tggacgccgg cagacacacc gaggacctgg tggaactggt gtccctgttc cccaccctgg     1260

ccggactggc tggactgcct gtgcccccca gatgccccat ccctagcttc cacgtcgaac     1320

tgtgcagaga gggccagaac ctgcagaaac atctgcagct gcacgacctg gaagaggaac     1380

ccgacctgtt cggcaacccc agagagctga tcgcctacag ccagtacccc agacccgccg     1440

acttccccca gtggaacagc gacaagccca gcctgaacga catcaaagtg atgggctaca     1500

gcatcaggac cgtggactac agatacaccg tgtgggtcgg attcgacccc agcgagttcc     1560

tggccaactt cagcgacatc cacgccggcg agctgtactt cgtggacagc gaccccctgc     1620

aggaccacaa cgtgtacaac gacagccagc acggcggcct gctgcacagc ctgaggcctt     1680

gagcggccgc gaattcgagc tcggtacccg ggaatcaatt cactcctcag gtgcaggctg     1740

cctatcagaa ggtggtggct ggtgtggcca atgccctggc tcacaaatac cactgagatc     1800

tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg     1860

gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctcac     1920

tcggaaggac atatgggagg gcaaatcatt taaaacatca gaatgagtat ttggtttaga     1980

gtttggcaac atatgcccat atgctggctg ccatgaacaa aggttggcta taaagaggtc     2040

atcagtatat gaaacagccc cctgctgtcc attccttatt ccatagaaaa gccttgactt     2100

gaggttagat tttttttata ttttgttttg tgttattttt ttctttaaca tccctaaaat     2160

tttccttaca tgttttacta gccagatttt tcctcctctc ctgactactc ccagtcatag     2220

ctgtccctct tctcttatgg agatccctcg acctgcagcc caagctgtag ataagtagca     2280

tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct     2340

gcgcgctcgc tcgctcactg aggccgcccg ggctttgccc gggcggcctc agtgagcgag     2400

cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg     2460

ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag     2520

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag     2580

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     2640

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     2700

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     2760

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     2820

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     2880

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     2940

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     3000

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     3060

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     3120

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     3180

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     3240

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     3300

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     3360

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     3420

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     3480

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     3540

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     3600

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     3660

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     3720

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     3780

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     3840

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     3900

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     3960

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     4020

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     4080

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     4140

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     4200

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     4260

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     4320

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     4380

cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta acctataaaa     4440

ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt gaaaacctct     4500

gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc gggagcagac     4560

aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg     4620

catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg cacagatgcg     4680

taaggagaaa ataccgcatc aggcgattcc aacatccaat aaatcataca ggcaaggcaa     4740

agaattagca aaattaagca ataaagcctc agagcataaa gctaaatcgg ttgtaccaaa     4800

aacattatga ccctgtaata cttttgcggg agaagccttt atttcaacgc aaggataaaa     4860

atttttagaa ccctcatata ttttaaatgc aatgcctgag taatgtgtag gtaaagattc     4920

aaacgggtga gaaaggccgg agacagtcaa atcaccatca atatgatatt caaccgttct     4980

agctgataaa ttcatgccgg agagggtagc tatttttgag aggtctctac aaaggctatc     5040

aggtcattgc ctgagagtct ggagcaaaca agagaatcga tgaacggtaa tcgtaaaact     5100

agcatgtcaa tcatatgtac cccggttgat aatcagaaaa gccccaaaaa caggaagatt     5160

gtataagcaa atatttaaat tgtaagcgtt aatattttgt taaaattcgc gttaaatttt     5220

tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc ttataaatca     5280

aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag tccactatta     5340

aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga tggcccacta     5400

cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc actaaatcgg     5460

aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa cgtggcgaga     5520

aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt agcggtcacg     5580

ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc gtactatggt     5640

tgctttgacg agcacgtata acgtgctttc ctcgttagaa tcagagcggg agctaaacag     5700

gaggccgatt aaagggattt tagacaggaa cggtacgcca gaatcctgag aagtgttttt     5760

ataatcagtg aggccaccga gtaaaagagt ctgtccatca cgcaaattaa ccgttgtcgc     5820

aatacttctt tgattagtaa taacatcact tgcctgagta gaagaactca aactatcggc     5880

cttgctggta atatccagaa caatattacc gccagccatt gcaacggaat cgccattcgc     5940

cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc     6000

agctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt cgggcgacct     6060

ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc aactccatca     6120

ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctact cgacattgat     6180

tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg     6240

agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc     6300

gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt     6360

gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc     6420

atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg     6480

cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg     6540

ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct     6600

ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg     6660

gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga     6720

ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg     6780

cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg ggagtcgctg     6840

cgttgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga     6900

ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat     6960

tagcgcttgg tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg     7020

ctccgggagg gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt gtgtgtgtgc     7080

gtggggagcg ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg cgggcgcggc     7140

gcggggcttt gtgcgctccg cagtgtgcgc gaggggagcg cggccggggg cggtgccccg     7200

cggtgcgggg ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg cgtggggggg     7260

tgagcagggg gtgtgggcgc gtcggtcggg ctgcaacccc ccctgcaccc ccctccccga     7320

gttgctgagc acggcccggc ttcgggtgcg gggctccgta cggggcgtgg cgcggggctc     7380

gccgtgccgg gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg gccgcctcgg     7440

gccggggagg gctcggggga ggggcgcggc ggcccccgga gcgccggcgg ctgtcgaggc     7500

gcggcgagcc gcagccattg ccttttatgg taatcgtgcg agagggcgca gggacttcct     7560

ttgtcccaaa tctgtgcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg     7620

cgcggggcga agcggtgcgg cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg     7680

tcgccgcgcc gccgtcccct tctccctctc cagcctcggg gctgtccgcg gggggacggc     7740

tgccttcggg ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac cggcggctct     7800

agagcctctg ctaaccatgt tcatgccttc ttctttttcc tacagctcct gggcaacgtg     7860

ctggttattg tgctgtctca tcattttggc aaagaattga ttaattcgag cgaa           7914


<210>  13
<211>  4333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9-CAG-omIDS

<400>  13
attacgccag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg       60

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa      120

ctccatcact aggggttcct tgtagttaat gattaacccg ccatgctact tatctactcg      180

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc      240

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa      300

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac      360

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca      420

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg      480

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt      540

agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc      600

ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat      660

gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      720

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      780

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      840

agtcgctgcg ttgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt     1080

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg     1140

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1200

gtgccccgcg gtgcgggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1260

tgggggggtg agcagggggt gtgggcgcgt cggtcgggct gcaacccccc ctgcaccccc     1320

ctccccgagt tgctgagcac ggcccggctt cgggtgcggg gctccgtacg gggcgtggcg     1380

cggggctcgc cgtgccgggc ggggggtggc ggcaggtggg ggtgccgggc ggggcggggc     1440

cgcctcgggc cggggagggc tcgggggagg ggcgcggcgg cccccggagc gccggcggct     1500

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1560

gacttccttt gtcccaaatc tgtgcggagc cgaaatctgg gaggcgccgc cgcaccccct     1620

ctagcgggcg cggggcgaag cggtgcggcg ccggcaggaa ggaaatgggc ggggagggcc     1680

ttcgtgcgtc gccgcgccgc cgtccccttc tccctctcca gcctcggggc tgtccgcggg     1740

gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg     1800

gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta cagctcctgg     1860

gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattgatt aattcgagcg     1920

aacgcgtgct agcgccacca tgagcccacc tcccccaccc ccaatctggc ggcagctgag     1980

cttcagcctg ctgctgggca gcttctgtat cgccctggaa agcgccaagc ttgcccaggg     2040

caacagcgcc accgacgccc tgaacatcct gctgatcatc gtggacgacc tgaggcccag     2100

cctgggatgc tacggcgaca agctggtccg cagccccaac atcgaccagc tggcttctca     2160

cagcgtgctg ttccagaacg cattcgcaca gcaggccgtg tgcgccccca gcagagtgtc     2220

tttcctgacc ggcagaaggc ccgacaccac cagactgtac gacttcaaca gctactggcg     2280

ggtgcacagc ggcaacttca gcaccatccc ccagtacttc aaagaaaacg gctacgtgac     2340

catgagcgtg ggcaaggtgt tccaccccgg catcagcagc aaccacagcg acgactaccc     2400

ctacagctgg tccttcccac cctaccaccc cagcagcgag aagtacgaga acaccaagac     2460

ctgcaagggc caggacggca agctgcacgc caacctgctg tgccctgtgg acgtggcaga     2520

cgtgccagag ggaaccctgc ctgacaagca gagcaccgag gaagccatca gactgctgga     2580

aaagatgaag accagcgcca gccccttctt cctggccgtg ggctaccaca agccccacat     2640

ccctttcaga taccccaaag agttccagaa gctgtacccc ctggaaaaca tcaccctggc     2700

ccccgacccc cacgtgccag attctctgcc ccccgtggcc tacaacccct ggatggatat     2760

ccgcgagcgc gaggacgtgc aggctctgaa catcagcgtg ccctacggcc ctatccccga     2820

ggacttccag agaaagatca gacagagcta cttcgccagc gtgtcctacc tggacaccca     2880

agtgggacac gtgctgagcg ccctggacga tctgagactg gcccacaaca ccatcattgc     2940

cttcaccagc gaccacggct gggctctggg agagcacggc gagtgggcca agtacagcaa     3000

cttcgacgtg gccaccagag tgcccctgat gctgtacgtg cccggcagaa ccgcccctct     3060

gcctgccgct ggacagaagc tgttccctta ccgggacccc ttcgaccccg ccagcgattg     3120

gatggacgcc ggcagacaca ccgaggacct ggtggaactg gtgtccctgt tccccaccct     3180

ggccggactg gctggactgc ctgtgccccc cagatgcccc atccctagct tccacgtcga     3240

actgtgcaga gagggccaga acctgcagaa acatctgcag ctgcacgacc tggaagagga     3300

acccgacctg ttcggcaacc ccagagagct gatcgcctac agccagtacc ccagacccgc     3360

cgacttcccc cagtggaaca gcgacaagcc cagcctgaac gacatcaaag tgatgggcta     3420

cagcatcagg accgtggact acagatacac cgtgtgggtc ggattcgacc ccagcgagtt     3480

cctggccaac ttcagcgaca tccacgccgg cgagctgtac ttcgtggaca gcgaccccct     3540

gcaggaccac aacgtgtaca acgacagcca gcacggcggc ctgctgcaca gcctgaggcc     3600

ttgagcggcc gcgaattcga gctcggtacc cgggaatcaa ttcactcctc aggtgcaggc     3660

tgcctatcag aaggtggtgg ctggtgtggc caatgccctg gctcacaaat accactgaga     3720

tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc     3780

tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc     3840

actcggaagg acatatggga gggcaaatca tttaaaacat cagaatgagt atttggttta     3900

gagtttggca acatatgccc atatgctggc tgccatgaac aaaggttggc tataaagagg     3960

tcatcagtat atgaaacagc cccctgctgt ccattcctta ttccatagaa aagccttgac     4020

ttgaggttag atttttttta tattttgttt tgtgttattt ttttctttaa catccctaaa     4080

attttcctta catgttttac tagccagatt tttcctcctc tcctgactac tcccagtcat     4140

agctgtccct cttctcttat ggagatccct cgacctgcag cccaagctgt agataagtag     4200

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     4260

ctgcgcgctc gctcgctcac tgaggccgcc cgggctttgc ccgggcggcc tcagtgagcg     4320

agcgagcgcg cag                                                        4333


<210>  14
<211>  646
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG promoter

<400>  14
actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc       60

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      120

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      180

caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      240

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      300

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      360

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      420

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      480

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      540

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      600

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgg                     646


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  15
ttttgtgtac tccaaccccg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer

<400>  16
tgtctgcata acagcccagg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer Mutation

<400>  17
gccctcacat tgccaaagga                                                   20


