                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  Prodrugs comprising a GLP-1/Glucagon dual agonist linker 
       hyaluronic acid conjugate

<130>  DE2015/071 WO PCT - 60235P WO

<150>  EP 15 305 858.1
<151>  2015-06-05

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  1

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Amidated C-terminus

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  3
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  6

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  8

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Gln Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  11

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  12

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala His Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  13

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  14

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  15

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Gln Asp Phe Ile Glu Trp Leu Ile Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  16

His Ser His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  17

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  18

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  19
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  20
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  20

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Glu Phe Ile Glu Trp Leu Ile Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  21
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  21

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  22
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Lys Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  23

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  24
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  24

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala His Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  25
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  25

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  26
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  26

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  27
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  27

His Ser His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  28
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  28

His Ser Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  29
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  29

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  30

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  31
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  31

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  32
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  32

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  33
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  33

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  34
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  34

His Ser His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  35
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  35

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  36

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  37
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  37

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln His Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  38
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  38

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Gln Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  39

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Gln Glu Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  40
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  40

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  41
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  41

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  42
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  42

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Val 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  43
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  43

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  44
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  44

His Ser His Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Lys Asp Phe Ile Glu Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  45
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  45

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  46
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  46

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly Pro Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  47
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Amidated C-terminus

<400>  47

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly Pro Pro 
            20                  25                  30          


Ser Gly Pro Pro Pro Pro Pro Pro Pro 
        35                  40      


<210>  48
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Amidated C-terminus

<400>  48

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Xaa Gly Pro Pro 
            20                  25                  30          


Ser Xaa Pro Pro Pro Pro Pro Pro Pro 
        35                  40      


<210>  49
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  49

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly Pro His 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  50
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  50

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Pro Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  51
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  51

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Pro Gly Pro Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  52
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  52

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Pro Gly Pro His 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  53
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  53

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly Pro Pro 
            20                  25                  30          


Ser Gly Lys Pro Pro Pro Ser 
        35                  


<210>  54
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  54

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly His Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  55
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  55

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly Trp Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  56
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  56

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly His Pro 
            20                  25                  30          


Ser Gly Lys Pro Pro Pro Ser 
        35                  


<210>  57
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  57

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Glu Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly Pro Pro 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  58
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  58

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Gly Gly Pro Arg 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  59
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  59

His Xaa His Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Leu Ala Arg Asp Phe Ile Glu Trp Leu Ile Xaa Xaa Gly Pro Pro 
            20                  25                  30          


Ser Xaa Ala Pro Pro Pro Ser 
        35                  


<210>  60
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exendin-4 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  60

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Leu Leu Glu Glu 
1               5                   10                  15      


Gln Arg Ala Arg Glu Phe Ile Glu Trp Leu Ile Xaa Xaa Gly Pro Pro 
            20                  25                  30          


Ser Xaa Ala Pro Pro Pro Ser 
        35                  
        


