                         б

<110>  Ŵѧ
 
<120>  Flu BĹ׵¡弰;

<130>  IEC150056

<150>  CN201510295723.3
<151>  2015-06-03

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  12G6CDR1

<400>  1

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  12G6CDR2

<400>  2

Val Asn Pro Tyr Ser Gly Gly Thr 
1               5               


<210>  3
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  12G6CDR3

<400>  3

Ala Arg Trp Asp Tyr Gly Val Tyr Glu Gly Tyr Ile Asp Tyr 
1               5                   10                  


<210>  4
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  12G6CDR1

<400>  4

Glu Lys Ile Tyr Ser Asn 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  12G6CDR2

<400>  5

Ala Ala Ile 
1           


<210>  6
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  12G6CDR3

<400>  6

Gln His Phe Trp Gly Thr Pro Leu Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  7G6CDR1

<400>  7

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  7G6CDR2

<400>  8

Ile Tyr Pro Asn Asn Gly Gly Thr 
1               5               


<210>  9
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  7G6CDR3

<400>  9

Val Arg Ser Gly Ala Tyr Tyr Phe Asn Tyr Leu Val Pro Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  10
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  7G6CDR1

<400>  10

Glu Ser Val Asp Ile Tyr Gly Asn Ser Phe 
1               5                   10  


<210>  11
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  7G6CDR2

<400>  11

Leu Ala Ser 
1           


<210>  12
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  7G6CDR3

<400>  12

Gln Gln Asn Tyr Glu Asp Pro Trp Thr 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  11B10CDR1

<400>  13

Gly Tyr Thr Phe Thr Gly Tyr Asn 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  11B10CDR2

<400>  14

Ile Tyr Pro Asn Asn Gly Val Thr 
1               5               


<210>  15
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  11B10CDR3

<400>  15

Val Arg Ser Gly Ala Tyr Tyr Val Asn Tyr Leu Val Pro Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  16
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  11B10CDR1

<400>  16

Glu Ser Ile Asp Ile Tyr Gly Asn Ser Phe 
1               5                   10  


<210>  17
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  11B10CDR2

<400>  17

Arg Ala Ser 
1           


<210>  18
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  11B10CDR3

<400>  18

Gln Gln Asn Tyr Glu Asp Pro Trp Thr 
1               5                   


<210>  19
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  12G6ɱ

<400>  19

Glu Val His Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Val Ala Trp Val Lys Gln Ser Pro Gly Glu Ser Phe Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Tyr Ser Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ile Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Tyr Gly Val Tyr Glu Gly Tyr Ile Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ser Ala Leu Thr Val 
        115                 


<210>  20
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  12G6ɱ

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Lys Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Glu Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Ile Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  21
<211>  124
<212>  PRT
<213>  ˹

<220>
<223>  7G6ɱ

<400>  21

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser Leu Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Ser Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Thr Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Ala Tyr Tyr Phe Asn Tyr Leu Val Pro Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 


<210>  22
<211>  111
<212>  PRT
<213>  ˹

<220>
<223>  7G6ɱ

<400>  22

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ile Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Lys Leu Glu Cys Gly Val Cys Ala 
    50                  55                  60                  


Arg Phe Asn Gly Ser Gly Cys Arg Thr Asp Phe Thr Leu Ala Ile Asp 
65                  70                  75                  80  


Pro Val Glu Gly Asp Asp Gly Ala Thr Tyr Tyr Cys Gln Gln Asn Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  23
<211>  124
<212>  PRT
<213>  ˹

<220>
<223>  11B10ɱ

<400>  23

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Tyr Pro Asn Asn Gly Val Thr Gly Tyr Asn Gln Glu Phe 
    50                  55                  60                  


Arg Ser Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Val Arg Ser Gly Ala Tyr Tyr Val Asn Tyr Leu Val Pro Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 


<210>  24
<211>  111
<212>  PRT
<213>  ˹

<220>
<223>  11B10ɱ

<400>  24

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ile Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Lys Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Asn Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Gly Asp Asp Gly Ala Thr Tyr Tyr Cys Gln Gln Asn Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  25
<211>  357
<212>  DNA
<213>  ˹

<220>
<223>  12G6ɱ(VH)ĺ

<400>  25
gaggtccacc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgtgagg cttctggata cacattcact gactactacg tggcctgggt gaagcagagc      120

cctggagaaa gctttgagtg gattggacgt gttaatcctt acagtggtgg tactagttac      180

aaccagaagt tcaagggcaa ggccacattg attgttgaca agtcctccag cacagcctac      240

atggagctca gcagcctgac atctgaggac tctgcggtct attactgtgc tagatgggac      300

tatggtgtct acgaggggta cattgactac tggggccaag gctccgctct cacagtc         357


<210>  26
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  12G6ɱ(VL)ĺ

<400>  26
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaaaatttac agtaatttag catggtatca gcagaaagag      120

ggaaaatctc ctcagctcct ggtctatgct gcaataagat tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttccctca agatcaacag cctgcagtct      240

gaagattttg ggacttatta ctgtcaacat ttttggggta ctcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  27
<211>  372
<212>  DNA
<213>  ˹

<220>
<223>  7G6ɱ(VH)ĺ

<400>  27
gaggtccagc ttcagcagtc aggacctgag ctggtgaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata cacattcact gactacaaca tgcactgggt gaagcagagc      120

cttggaaaga gccttgagtg gattggatat atttatccta acaatggtgg tactggctac      180

aatcagaagt tcgagagtaa ggccacattg actgtagaca attcctccag cacagcctac      240

atggagctcc gcaccctgac atctgaggac tctgcagtct attactgtgt aagatcagga      300

gcctactatt ttaactacct agtcccctac tttgactact ggggccaagg caccactctc      360

acagtctcct ca                                                          372


<210>  28
<211>  333
<212>  DNA
<213>  ˹

<220>
<223>  7G6ɱ(VL)ĺ

<400>  28
aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcttgca gagccagtga aagtgttgat atttatggca atagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatttatc ttgcatccaa actagaatgt      180

ggggtgtgtg ccaggttcaa tggcagtggg tgtaggacag acttcaccct cgctattgat      240

cctgtggagg gtgatgatgg tgcaacctat tactgtcagc aaaattatga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  29
<211>  372
<212>  DNA
<213>  ˹

<220>
<223>  11B10ɱ(VH)ĺ

<400>  29
gaggtccagc ttcagcagtc aggacctgag ctggtgaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata cacattcact ggctacaaca tgcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggaaaa atttatccta acaatggtgt tactggctac      180

aaccaggagt tcaggagcaa ggccacattg actgtagaca attcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcaatct atttctgtgt aagatcagga      300

gcctactatg ttaactacct agtcccctac tttgactact ggggccaagg caccactctc      360

acagtttcct ca                                                          372


<210>  30
<211>  333
<212>  DNA
<213>  ˹

<220>
<223>  11B10ɱ(VL)ĺ

<400>  30
aacattgtgc tgacccaatc tccagcctct ttggctgtgt ctccagggca gagggccacc       60

atatcctgca gagccagtga aagtattgat atttatggca atagttttat gcactggtac      120

cagaagaaac caggacagcc acccaaactc ctcatttatc gtgcatccaa cctagaatct      180

ggggtccctg ccaggttcaa tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg gtgatgatgg tgcaacctat tactgtcaac aaaattatga ggatccgtgg      300

acgttcggtg gaggtaccaa gctggaaatc aaa                                   333


<210>  31
<211>  25
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  31
ccgtttgkat ytccagcttg gtscc                                             25


<210>  32
<211>  25
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  32
cggtgaccgw ggtbccttgr cccca                                             25


<210>  33
<211>  29
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  33
atggactcca ggctcaattt agttttcct                                         29


<210>  34
<211>  29
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  34
atgaagttgc ctgttaggct gttggtgct                                         29


<210>  35
<211>  29
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  35
atggactcca ggctcaattt agttttcct                                         29


<210>  36
<211>  25
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  36
atggagacag acacactcct gctat                                             25


<210>  37
<211>  26
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  37
atgraatgsa sctgggtywt yctctt                                            26


<210>  38
<211>  27
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  38
atggtyctya tvtccttgct gttctgg                                           27


<210>  39
<211>  576
<212>  PRT
<213>  в

<400>  39

Met Val Val Thr Ser Asn Ala Asp Arg Ile Cys Thr Gly Ile Thr Ser 
1               5                   10                  15      


Ser Asn Ser Pro His Val Val Lys Thr Ala Thr Gln Gly Glu Val Asn 
            20                  25                  30          


Val Thr Gly Val Ile Pro Leu Thr Thr Thr Pro Thr Lys Ser His Phe 
        35                  40                  45              


Ala Asn Leu Lys Gly Thr Glu Thr Arg Gly Lys Leu Cys Pro Lys Cys 
    50                  55                  60                  


Leu Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Thr 
65                  70                  75                  80  


Gly Asn Ile Pro Ser Ala Arg Val Ser Ile Leu His Glu Val Arg Pro 
                85                  90                  95      


Val Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg 
            100                 105                 110         


Gln Leu Pro Asn Leu Leu Arg Gly Tyr Glu His Ile Arg Leu Ser Thr 
        115                 120                 125             


His Asn Val Ile Asn Ala Glu Asn Ala Pro Gly Gly Pro Tyr Lys Ile 
    130                 135                 140                 


Gly Thr Ser Gly Ser Cys Pro Asn Val Thr Asn Gly Asn Gly Phe Phe 
145                 150                 155                 160 


Ala Thr Met Ala Trp Ala Val Pro Lys Asn Asp Asn Asn Lys Thr Ala 
                165                 170                 175     


Thr Asn Ser Leu Thr Ile Glu Val Pro Tyr Ile Cys Thr Glu Gly Glu 
            180                 185                 190         


Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp Asn Glu Thr Gln Met 
        195                 200                 205             


Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala 
    210                 215                 220                 


Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn 
225                 230                 235                 240 


Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp 
                245                 250                 255     


Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr Ile Thr Tyr Gln Arg 
            260                 265                 270         


Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Lys Ser Lys 
        275                 280                 285             


Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu Ala Asp Cys Leu His 
    290                 295                 300                 


Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro Tyr Tyr Thr Gly Glu 
305                 310                 315                 320 


His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp Val Lys Thr Pro Leu 
                325                 330                 335     


Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu Leu Lys 
            340                 345                 350         


Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp 
        355                 360                 365             


Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His 
    370                 375                 380                 


Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn 
385                 390                 395                 400 


Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn 
                405                 410                 415     


Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu 
            420                 425                 430         


Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser 
        435                 440                 445             


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser 
    450                 455                 460                 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
465                 470                 475                 480 


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
                485                 490                 495     


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
            500                 505                 510         


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
        515                 520                 525             


Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr 
    530                 535                 540                 


Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile 
545                 550                 555                 560 


Phe Val Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Phe His Ser 
                565                 570                 575     


<210>  40
<211>  579
<212>  PRT
<213>  в

<400>  40

Met Val Val Thr Ser Asn Ala Asp Arg Ile Cys Thr Gly Ile Thr Ser 
1               5                   10                  15      


Ser Asn Ser Pro His Val Val Lys Thr Ala Thr Gln Gly Glu Val Asn 
            20                  25                  30          


Val Thr Gly Val Ile Pro Leu Thr Thr Thr Pro Thr Lys Ser His Phe 
        35                  40                  45              


Ala Asn Leu Lys Gly Thr Gln Thr Arg Gly Lys Leu Cys Pro Asn Cys 
    50                  55                  60                  


Leu Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Met 
65                  70                  75                  80  


Gly Thr Ile Pro Ser Ala Lys Ala Ser Ile Leu His Glu Val Lys Pro 
                85                  90                  95      


Val Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg 
            100                 105                 110         


Gln Leu Pro Asn Leu Leu Arg Gly Tyr Glu Asn Ile Arg Leu Ser Ala 
        115                 120                 125             


Arg Asn Val Ile Asn Ala Glu Thr Ala Pro Gly Gly Pro Tyr Ile Val 
    130                 135                 140                 


Gly Thr Ser Gly Ser Cys Pro Asn Val Thr Asn Gly Lys Gly Phe Phe 
145                 150                 155                 160 


Ala Thr Met Ala Trp Ala Val Pro Lys Asn Lys Asn Lys Thr Ala Thr 
                165                 170                 175     


Asn Pro Leu Thr Val Glu Val Pro Tyr Ile Cys Thr Lys Gly Glu Asp 
            180                 185                 190         


Gln Ile Thr Val Trp Gly Phe His Ser Asp Asn Glu Ala Gln Met Val 
        195                 200                 205             


Thr Leu Tyr Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn 
    210                 215                 220                 


Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn Gln 
225                 230                 235                 240 


Thr Glu Asp Glu Gly Leu Gln Gln Ser Gly Arg Ile Val Val Asp Tyr 
                245                 250                 255     


Met Val Gln Lys Pro Gly Lys Thr Gly Thr Ile Val Tyr Gln Arg Gly 
            260                 265                 270         


Val Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys Val 
        275                 280                 285             


Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu Ala Asp Cys Leu His Glu 
    290                 295                 300                 


Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His 
305                 310                 315                 320 


Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp Val Lys Thr Pro Leu Lys 
                325                 330                 335     


Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu 
            340                 345                 350         


Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu 
        355                 360                 365             


Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly 
    370                 375                 380                 


Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys 
385                 390                 395                 400 


Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu 
                405                 410                 415     


Gln Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu 
            420                 425                 430         


Leu Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln 
        435                 440                 445             


Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu 
    450                 455                 460                 


Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly 
465                 470                 475                 480 


Pro Ser Ala Val Asp Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys 
                485                 490                 495     


Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asn Ala 
            500                 505                 510         


Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala 
        515                 520                 525             


Ser Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535                 540                 


Ser Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile Phe 
545                 550                 555                 560 


Ile Val Tyr Met Val Ser Arg Asp Asn Val Phe Leu Leu His Leu Ser 
                565                 570                 575     


Ile Arg Lys 
            


