                         SEQUENCE LISTING

<110>  Cornell University
 
<120>  ADENO-ASSOCIATED VIRUS MEDIATED DELIVERY OF C1EI AS A 
       THERAPY FOR ANGIOEDEMA 
       

<130>  724069

<150>  62/324,183
<151>  2016-04-18

<150>  62/167,603
<151>  2015-05-28

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic AAM21515.1 (C1EI AA sequence)

<400>  1

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  2
<211>  22243
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic AF435921.1 (C1EI nucl. Sequence)

<400>  2
gcccagatgg cctccaggct gaccctgctg accctcctgc tgctgctgct ggctggggta       60

tgtggtccct tgtgggatgg gggacggggg tggagacggg aggcgggatg gtgcggggtg      120

cgggcggtgg ctgaggatta acccttcagg ctccggggaa tgaggagagc tcctcttggg      180

atcattgagt gtgatccttg cacacgcact cgtagatggt ggaaagagct caggactcag      240

acagatgcaa gttctaatct tggcgggcca tgtaggagct gcgcagcgtg gtcctgagga      300

cgtcactttt ctcagcctac tcctcctgat ttataaaatg ttgaataaac agatcccacc      360

ctgtccacca agcaggcttg gcaggaggat cacatagggc aaggagatgg gaagcatttt      420

gtgatatcaa agcaagagtt tgttgtagaa aagagctgtg gggaggagag gtttggctgc      480

tgtgacacag acggtggtcc caggctaggg cctgtgaaga cagggaagaa tggtagcaaa      540

catacgtggg tctgggtggg ggtcaatagc agtgagaggt cccagtggtc tgggaggtca      600

tggactagaa ataaggctaa gaagtgcagg atcccaggag aaaggtaggt aggggtgtgt      660

gtatgtgcgt gtgtgtgtgt gtgcacgcgc aagttggtat cacatactca gcagatgatg      720

tagttatgag cagggagttt ggaatcagag accttgtttt gacccctagc tgtttctccc      780

atttctgtga gaccctggac tagttaatat gtgtcggtat gagtttctct acctgtgaaa      840

tggagctaat gcgtggtttc tcagtggagg atctgttgac attggggctg gataattcat      900

tgctgagggg ctaccctgcg cattttagga tgttttgcag tatatctcta gcctctacgc      960

actagattcc ggtagcatct tccctgctgt ctccctgtga caaccaaaaa tgtctctgga     1020

cattgccaaa tatcccctgg gagtcaaaat tgtttcagag ccgctggcct atactacttc     1080

tctctccctc ccttcctgcc tcccttcttt cctccttccc tttcttcgtt cccttcctaa     1140

tgtgtactgt ttttccacac ccactaatgg gttgcaaccc acagtttaaa aatttactgt     1200

tctaaatcaa ggagcacaag ttcaaatgtc tgtactagcc aagcaagtga gtcaaacagg     1260

tagatattta caggaaattg caagaacata gataaatgac aacactcagc ttcactgttt     1320

ggaaaacaac ttcctacagg gcagtaattg gtcagagatt acagagtccc tgactatccc     1380

tcatcttctg cagagcacat tcctgtgcac ccccaccctc accctgtatt gccccttctc     1440

tgaggaatta gtggtggtgg ttctaagaca gattgctcat ctgccgcact gtcagaaatt     1500

actctcttgt acaggacatt ttccacatcc acaccttctc ttcctgcttt gagtatttta     1560

gaggactgtg cctcgtagta agaaaaaaat gaaactcagt ttcttgaacc acaggataga     1620

gcctcctcaa atccaaatgc taccagctcc agctcccagg atccagagag tttgcaagac     1680

agaggcgaag ggaaggtcgc aacaacagtt atctccaaga tgctattcgt tgaacccatc     1740

ctggaggttt ccagcttgcc gacaaccaac tcaacaacca attcagccac caaaataaca     1800

gctaatacca ctgatgaacc caccacacaa cccaccacag agcccaccac ccaacccacc     1860

atccaaccca cccaaccaac tacccagctc ccaacagatt ctcctaccca gcccactact     1920

gggtccttct gcccaggacc tgttactctc tgctctgact tggagagtca ttcaacagag     1980

gccgtgttgg gggatgcttt ggtagatttc tccctgaagc tctaccacgc cttctcagca     2040

atgaagaagg tggagaccaa catggccttt tccccattca gcatcgccag cctccttacc     2100

caggtcctgc tcggtaagac cctgcttgaa ttctctccag gtcatttgtt ggacactccc     2160

ataagagtca ccaatccaga cacttacaaa gccatgcctc tgggaagaag ctgtaaaaat     2220

gggctattat atattggggg tggggtagag ggatgtatct tttcattctt gaacattcca     2280

tcatttcaca gtgatgtaat aggcacgatt gcttgtaaaa ctctgtgact atacaagaac     2340

atataaaata aggtcgcagc cactaaccat gtttcatggc aaggagaggt gataagaaag     2400

atgaaattag gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccaaggcggg     2460

tggatcacct gaggtcagga gttcaagacc agcctggcca acatggtgaa accctgtctc     2520

tactaaaaat acaaaaatta tcagggagtg gtggtgcatg cctgtaatcc cagctacttg     2580

ggcagctgag gcaggagaat cgcttgaacc caggaggtgg aggttgcagt gagccgagac     2640

cgcaccattg cactacagtc tgggtgacag agcgagactc tgtctcaaaa aaaaaaaaaa     2700

attatcagag atagacctag agtagatgtg gttagtactg ccttctagct ctgtgacctt     2760

gggcagatca ctttaacctc tctgagcctt gagtcctctt gtgtaaaata gtgatgatgc     2820

tatctacctc aaaagattaa gaagcagaaa gccaggccgg gtgcggtggt tcacacctgt     2880

aatcccagca ttttaggagg ccgaggcggg cagatcacga ggtcaggagt tcgagaccag     2940

cctgactaac atggtgaaac cccgtctcta ctaaaaataa aaagaaatta gctaggcatg     3000

gtggtgcaca cctgtaaccc cagctactca ggaggctgag gcaggagaat cacttgaaca     3060

cgggaggcag aggttgcagt gagccgaaat catgccactg cactccagcc tgggaagact     3120

gagcaagact ctgtctcaaa aaaaaaaaag aagcagccta gtgtctgact tagtgggagg     3180

tcaaaaaaat gtaaatcctc tgccatcttg agggattact gtcaagtccc atttggtaat     3240

taccctagga atggcacaaa caaattacta caagcagtgg ggacagagct attactcccc     3300

agagagaatt ctaaaaaggc tacagaatct ttcttggctg ggcacggtga ctcacaccta     3360

taatcctggc actttgggag gccaaggcag gagttcaaga ccagcctggc caacatgttg     3420

aaaccccatc tctactaaaa atgcaaaaat tagccaggca tagtgatgca tgcttattgt     3480

cccagctact tgggaggcag aggtgggagg attgcttgaa cctggagatt caagtgagct     3540

gagattgcac cactgcattc cagcctgggc aacaaagcaa gactctgtct caaaaaaaaa     3600

aaaaaaaaaa aaaaaagaga gattgagaga acacttccag ctcagatgat ctgtgatccc     3660

ctccaaagca gggaataccc tccattccag cctggtcccc aaccctcatt cccaaggaag     3720

gcccccgact catcctgcaa gtatctttca tctctgccct ttgttgcagg ggctggggag     3780

aacaccaaaa caaacctgga gagcatcctc tcttacccca aggacttcac ctgtgtccac     3840

caggccctga agggcttcac gaccaaaggt gtcacctcag tctctcagat cttccacagc     3900

ccaggtgagt gcccaggaat gggcagtgtc tgcagaggag ggtcctgaga ggactctgaa     3960

gggggaccca gcgctgggga aagaaaggac agagggaatg ttggagctac agtatcaggg     4020

atggactgca gagcaggtga agaccttggc aggagcatta ggtcactcca ggaactagac     4080

tgttcttcta atgagacctt agacaagtct ctggcattca tcaactgctt tagaataaaa     4140

ataaccgggc aggtacagta aaatagtgat gatgctatct acctcaaaag attaagaagc     4200

agaaagccag gctgggcgtg gtggctcaca cctgtaatcc cagcactttg ggaggccgag     4260

gcaggtggat cacgaggtca ggggttcgag accagcctga ccaacatggt gaaaccctgt     4320

ctctactaaa aatacaaaaa ttagctgggc atggtggcgg gcacctgtaa tcccagctat     4380

tcaggaggct gaggcaggag aattgcttga acctgggagg cggaggttgc agtgagccga     4440

gatgacgcca ctgcactcca gcctgggcga cagagcaaga ctccgtctca aaaaaaaaaa     4500

caaaaacaaa acaaaaacaa aaaaaaaaac aaagaaggag aaagccgggc cgggcatggt     4560

ggctctcatc tgtaagttca aggagttgaa ggtatgctag gactttggga ggccaaggcc     4620

ttcaagacca gcctgggcag catggcgaaa cctgtctcca ttaaaaaaaa aaaagttggg     4680

ggtacggctg ggcatggtgg ctcacacctg taatcccagc actttgggag gctgaggtgg     4740

gtggaacacc tgaggtcagg agttcaagac cagcctggcc aacatggcaa aaccctgtct     4800

ctattaaaaa cacaaaaatt agcctggcat ggtggcaggc gcctataatc ccaactactc     4860

aggaggctga ggcaggagaa tcgcttgaac ccaagagagt gaaggttgca gtgagctgag     4920

atcatgccac ttcactccag cctgagtgaa acagcaaaac tctgtctcaa aaaaaaaaaa     4980

aggaagaaag aaaaaaggcc aggcgcggtg actcacgcct gtaatcgcaa cactttggca     5040

ggccgaggca ggcgattcac aaggtcagga gttcgagacc agtctggcta actaacatag     5100

tgaaactccg tctctactga aaatacaaga aattaccctg gcatggtggt gtgcacctgt     5160

aatcccagct actcaggagg ctgaggcagg agaatcgctt gaacctggga ggcagaggct     5220

gcagtgagcc gagatcgcgc cactgcactc cagcctggat gacagagcaa gactctgtct     5280

caaaaaaaaa aggccgggcg cggtggctca tgcctgtaat cccagcactt tgggaggctg     5340

aggcgggcgg accacgaggt cagaagatca agaccatcct ggctaacaag atgaaaccct     5400

gtctctgcca aaaaaataca aaacttagcc gggcatggtg gcaggcgcct gtggtcccaa     5460

ctacttggga ggctgaggca ggagaatggc atgaacccgg gaggcggagc ttgcagtgag     5520

ccgagattgc gccactgcac tccagcctgg gcaacagagc gagacaccat ctcaaaaaaa     5580

aaaaaaaaaa atggggcggg cgggccaggc gcggtgtctc acacctgtaa tcccagcact     5640

ttgggaggct gaggtgggcg gatcacttga ggtcaggagt tcaagaccag cctggccaac     5700

accaggaaac cctgtctctg ttaaaaatac aaaaattagc caggtgtggt ggcacgcgcc     5760

tgtagtccca gcaggagaat aacttcaacc tgggagacag aggttgcagt cagctgagat     5820

cgcaccactg cattccagcc tgggtgacag accgagactc tgtctcaaaa aaaaaaaaaa     5880

aagaagaata cccatatgca ttcattaata tatagggcta gagggctaga gagctataga     5940

cataaaatag acaaaaaatt tttttgctca tttttgggtc aaaggagtct tgggactcta     6000

attcttttaa tttttgtgtt atgtgaattt gttatcattt acatgtatta tgttattaag     6060

taggtaataa tgataatact aataataaac ttacaaaacg atccaatgta gttgttttca     6120

gactttgttc ctcggagccc taggactttg caaagctgtt tctggagtca tggtgggagt     6180

ggggtgtggg gagcctgagc agtggggaag ggttcaccac ttcctgtgag agggaaacgg     6240

accagctggg ctctgagctc cccacccagc ctcagccagg gtccatttta tattgtgggc     6300

ttcagacatg cctttgtttg aaagcagttc tgctgcttta aaatgtttga taaccattga     6360

actaatctac ccacctccct ttttaaaaaa aaaaggaaaa ctttttttta agctgttttt     6420

tttgtttttt gttttttttt aaactgtaaa aacaatactt aggtctggct cagtgtgcct     6480

gtaattccaa cactgagagg ctgaggtagg aggattgctt gaggctagaa tttcgagact     6540

agcctctggg caacatagac agacctcatc tctacaaaaa attttaaaaa ttatccgggt     6600

gtggtacgtg tctgtagttc cagctatgaa ggactgagac gggaggattg cttgagccaa     6660

ggaattcgaa gttagagtga gctatgttta tgcctctgta ctctaggttg ggtaacagag     6720

taggaccctg tctctaaaaa aaaaaaaatt taatttaaat tttaaaaact cacctatcac     6780

cccatcatct gaaaaacacc ctctttcaga tgtgggaaaa acatggctca gaggtgttca     6840

agaaatgttg catttattta ttacttacaa agctgtaagt cagctttatc cgctgtcttg     6900

ctaggttggt gaaaaatacg taacagcatt caatattagg gcttctatcc ccatctagct     6960

gcacactgga gctgtgccaa gcaaggttct tggtcttatg ttgtacttag gcatcagcaa     7020

agcctgggaa aatatctttt tttttttttt gagacagaat ctcgctctgt cgcccaggct     7080

ggaatgcagt ggcaccatct cagctcactg caacctccgt ctcccagatt caagtgattc     7140

tcctgcctca gcctcccgaa tagctgggat tacaggctgg tcttgaactc ctggcctcca     7200

gtgatccacc caccttggcc tcccaaagtg ctgcgattac aggtgtgagc caccatgccc     7260

agctggggaa aatatcttta atctacttag tcctagaaaa attatctttc aagtgctttt     7320

tttttttttt tcagtggact gaaggctttt gcagagcaaa agccaggaag ttttgtcaca     7380

aacttccacc aaggccagga agcagagtct attccgtgcc aaaattaagg gaagaaaaga     7440

gggaaaatct aggcaaatgg aatttaatat ctcaaaaaga ttatcttgcc gagccatagt     7500

cacatagcaa gctgaggcag cggaggcttg gggctacttc tcttgttctt ggttctgggt     7560

ttaccttctt tgggccttat ttgccacatc tgtaagagga gtgggctgga ccgcgctcca     7620

ccatgccgta ttcactaagt gagcagatag aaccatagaa agcatgctca ctctcaaatc     7680

gtgctcatgg aaagaacgac gtgttcagga ctcatgcctc cctttctcaa cataccccca     7740

gacctggcca taagggacac ctttgtgaat gcctctcgga ccctgtacag cagcagcccc     7800

agagtcctaa gcaacaacag tgacgccaac ttggagctca tcaacacctg ggtggccaag     7860

aacaccaaca acaagatcag ccggctgcta gacagtctgc cctccgatac ccgccttgtc     7920

ctcctcaatg ctatctacct gagtggtaag ggtgccctta gccagttagt cttcccattc     7980

tgggtccttc ttcccctcct ggcttcaaag cccacttaac cccaagttct acaatcggat     8040

ctcaatgtcc ctgcactact ctttgctaac aaggctttta gctcctcttc atccttttcc     8100

tacctgcatt agagcaaccc tcccacctct tccctctagc caagtggaag acaacatttg     8160

atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata aaagtgccca     8220

tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg aaagccaagg     8280

taagttctta acctttcctt ctcctgtttg aaacctactt gagtctcctg actttttttc     8340

tgctgtagtc ccatcatttt ggggtacatg cttacaaatt catcacttct actccttcca     8400

tctgtatttc caccctatct tttctccttc tcctttctct agccttggcc aaggcagaca     8460

ttgtatattt taggctggaa acaggattct caagtttctt catgcatctc tactatattg     8520

aatggcaaaa tgtgagtcgt gttcctattc tacacatctg tttctttttc cagtcaactc     8580

atcagaagac tctggtggct tagcaagtcc tgtgtgtatg tgggtacctg tgtacagcat     8640

acatatacat gtgtagacgt gtataagtat atccttgtat atgcatatat gtggtaagtg     8700

catgtgtgca catgagttaa atggcttaag tgcattagca gaaattgaac aatttagttt     8760

gatgagtagg gagggagaga agacagaata tggagcccag aggatcccaa ctggcaagct     8820

atctcatccc cagttaccag atatttccac ctttttagga tggcaaaaca cagacctatg     8880

agacagaaaa cagtaagaga caatgtctca atacctggct gagaaacaaa ggctctgttc     8940

ttggaacatg ctaggcttgg ttccacattg ggagctttcc ttagcttttg tttctgcctg     9000

tatccctctt cactcagatc ctcacatagc ttgttccttc ttgtcatttg ggtgtcagct     9060

cagaggtcac cttggtggag aagtcttctc cccattaaag cagcctcctc ctcaccctgt     9120

aatatcactc ctgttttatt atattcatta cactcatcac catctgaaat tatgtcattt     9180

atttgcttat ttgcctagga cattgtctgt ctccctaaga tactgtctct ctacttgaat     9240

acaggaacct gtcttgtttc cttctgtatc tgtagtgcct agaacaatgc ctcctatcat     9300

aggtgctcat tcagtgtttg ctgaataaat gaatgaatga aatagagggt gccaaagaga     9360

gctactcagt aaaagtggct ggaagacttc atagaggagg gttttttttc gagacagggt     9420

ctcactctgt cactcaagct gcagtgcatt gacatgatct cagctcactg caatctctgc     9480

ctcccgagtt caagcagttc tcctgcctca gcctcccaag tagctgggac tacaggagcc     9540

cgccaccaca cctggctaat ttttgtattt ttagtagaga cggggtttca ccatgttagc     9600

caagctggtc tcgaactcct gacctcaagt gatccacacc ctcagcctcc caaagggctg     9660

ggattacagg catgagccac agcacccagc tgaggaggtt atttttgacc attctttgct     9720

cagttattta tccactcatg gacttatcca cccatctatc catccctatc taatgtattt     9780

gaccattcat gactcattta gcagaaccag gacagcctgt ataaggcaca gaagagtgaa     9840

tatatgtgac aggtccagag cattgttcaa attcaagata cgttggggga ggtataaata     9900

tgagattttt ttcaaatcaa ttggaatggc tatttaatca aagccataga tgttaggtgg     9960

aaagtaggaa ttaagaactt aacaagttag gtttaaatgt aactattcga attataagaa    10020

caagtatttc ctctctaaaa atgtttttaa agtttcacac aaaactctaa accaaaaatc    10080

attgtaaaaa tcccttggga gtagactgtt gaaaccattg aggtgaggtg ataggttaag    10140

gtgagcattc tggacatata atatcaataa taaatattca aatacaaagc aggtataata    10200

tgaagagtaa tttctatctc cccaagccaa tatgagtttt gtttgtttgt ttgtttttct    10260

tttgagataa agtctcattc tgttgcccag gccggagtgc agtggcacaa tcccagctct    10320

ctgtaacctc tgcctcccag gttcaagcga ttctcctgcc ttagcctccc tagtagctgg    10380

gattataggc gcctgccacc actcccagct aatttttgta tttttagtag agatggggtt    10440

tcaccatgtt ggccaggctg gtcatgaact cctgacctca agtgctcgtc cgtcttcggc    10500

ctcctaaagt gctggcatta caggcgtgag ccactgcacc cagcctgagt tttttttttt    10560

tttttaagcc aaaggaggag gagtagtttt gtgcacaaaa gccactattt agagttcctt    10620

aggttttaaa cagataatta atttaatgta ctaacaaatg caaaattaaa attttactta    10680

tgccttttaa ttttaagctg aacttgctac attaagagta gggtgatttg gctgggcgca    10740

gtggctcatg cctataatcc cagcacttta ggaggctgag gcaggtggat cacttgaagc    10800

taagagtttg agaccagcct ggccaacatg gtggaattct gtctctacta aaaatacaaa    10860

aattagccag gcatggtggc acatgtctgt aatcccagct actcaggatg ctaaggcaca    10920

gaatcacttg aacctgggag gcagaggtta cagtgagcca aaatcgcgcc actgcactcc    10980

aacctgggca acacagcaag actctgtctc aaaacacaaa aaaagaatag gctgggtaca    11040

gtggctcacg cctgtaatcc cagcactttg ggaggccgag gcaggtgaat cacctgaggt    11100

caggagttcg agaccagctt ggccaacatt gtgaaacccc atctccatta aaaatacaaa    11160

aaataagccg ggtgtgatgg tgcacgcctg taatcccaga tacttgggag gctgggacag    11220

aagaatcgct tgaacccggg aggcgaaggt tgcagtgagc cgagatcatg ccactgcatt    11280

ccagcctgag cgacagagtg agaccttgtc tcagaaaaaa aaaaataggg tgatttttat    11340

ataaaaacac tctcatttgt tcttgaatta attgccatat tgaacagatt aaactccttt    11400

aaaccatttt ttctatctac aaacataatt agtattccca taagcatttt aagctccctt    11460

taaaaattta atatgctcga ttttcttttt tcttttattt atttatgtag ttttcccaga    11520

cagggtctta ctctatcacc cagtctggag tacagtgaca caatcctcac ttactgtaac    11580

ctcaagctcc ttgggatgaa gcagtcctcc caccctagcc tcttaagtag ctgagattcc    11640

aggcatgagc cacctcaccc agctgatttt ctttttaaac acatctaata cctgacaggt    11700

cgtaattacg actgtgcttg gccatatcat cctaacacct aaagctcact tgtaaactga    11760

aaattaaatt tgaagggtga attaacttct agccaacatt ccaatatcat tctcacattt    11820

aatgaaatta tcctacaact ttgcttaaaa gcataaaact agcatgtcag agtctcttaa    11880

aaattacaat cactatttta aataacaaac atacaggtta ccctgaactt aacacctggt    11940

tttaacatga tgaagttggt ttcttttgtc attcttatac taaattctaa atcttcctgg    12000

cacttaagga tatttaccca aggaaggggg tgagatttac cggctcaggt acaccgaggt    12060

tactggcttg aaaattcaag accacagcat ggtaaatttt tcttcagaga ttcaaggttc    12120

atacatagga cttgaagggc acatgctact caaatgagta tatccaactt gagtgctaca    12180

tcaacaggga ccccatgtcc actcttttca gtcgaaattg gcttactatc tacttcttct    12240

gggctattca gtttccgaca attgattgct ttcagttaat ttctttattg cccagttgaa    12300

ttctgcattc ttctagattc tttttgttcc ttcagcctca atcataatac catttaatga    12360

cagtctcata tcctattaga ctagggtttc tcagccttgg cactattgac atattgggtc    12420

agataattct ttgtcctgtg cattgtagaa tttagcatct tccttagctt ctactcacta    12480

gaagccagta gcactgtgtg cacatcctcc ttgccccctg ccagctatga caaccaaaat    12540

gtctccagac attaccaaat gtccactgag aggcaaattc actctgagtt gacaacccct    12600

gtattaaacc caggggccct gcacttctta catacttttg tctggtcacc agttgaaagt    12660

ccttcttctt ttttttttct ctttttgaga tggagtctcg ctctgtcacc aggctggagt    12720

gcagtggcat gatctcggct cactgcagcc tccacctccc gggttcaagc aattctcctg    12780

cctcagcctc ctgagtagct gggattacag gcacgtgcca ccacccagct aatttttgta    12840

tttttagtag aggtggggtt tcatcatggt ggccaggatg gtctcaatct cttgacctca    12900

tgatccgccc acctcggcct cccaaagtgc tgggattaca ggtgtgagcc accgtgcatg    12960

accaaaagtc cttctaatag caaagtggaa aggtaggctg tgaacaatct tgaatgccat    13020

actaagattt gtacttattc tcataggcag tgaagagcca tcaatagttt ttacagaggc    13080

tgacctgata actctggcgg ttcaatgtgc atgctatata ctatatgcac aacacattag    13140

gaaggaaggg aacagcgctc agagaaatca aatcacttgc ccatattaca tagctcgtca    13200

gtggtggagt cagggtataa tcagaaactc atgctccttc ctctacctct ccccagcaca    13260

gagttggatc agcactgttc acccagctgg tatccccatt tcatggtaaa gcctggaagc    13320

ttaggtctga ctgatgcttg ttgaaataca gactgtggga gcagactgca ggacagcatt    13380

gtgacagagg gtggggccag gagagagatg cggtaggaag actgttaagg tgcatctctt    13440

attttctagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc    13500

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag    13560

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc    13620

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattggg tgagctctgg    13680

cagcttaggg ttactcccag gccatcagag gagaaagggg ggatccctaa gatgtagtta    13740

gcattctcta gagtattttt tacatccata atctcagttt gtcctgcaac cctgcaagtt    13800

agaggggtag gtgctattat cccattggat cattgtggaa atggaggctc agaagcttta    13860

tgtgacttac ccagagattc catgatttac ccttgagcta gtcagaggca aaccagaaca    13920

ccgacccagg tctccagctc tcctgagttt tttctatggt tccttgtgac ataggcagtg    13980

gaacagtggg acaggtaacc gaggtgaatt atggatgctc cttccccaga cacatttcaa    14040

aacagtcagc caccccgtgg aatatgcaag aagctatctg gaagtgcaga tctggaggct    14100

tctgagttta cgagaggcaa cagagactcc attttctttt tttttttttt ttttgagacg    14160

gagtcttgct ctgtcaccca ggacaggctg gagtgcagtg gtgcgatctc tgctcactgc    14220

aagatccgcc tcccagattc acgccatgcc attctctcgc ctcagcctcc cgagtagctg    14280

ggactacagg tgcccgccac cacgcctggc taattttgtt tttgtatttt tagtagagac    14340

ggggtttcac tgtgttaacc aggatggtca caatctccgg accttgtgat ccacctgcct    14400

cggcctccca aagtgctggg attacaggca tgagtcaccg cgcccagccc agagactcca    14460

ttttctaacc tttgtttttt tgtttgtttg tttttgagac ggagcctcac tctgtcaccc    14520

aggctggagc gcagtggcat gatcttgggt cactgcaacc tccgcctcct gggttcaagt    14580

gattctccta cctcagcctc ccaagtagct gggattacag gcacctacca ccacgcccag    14640

ctaatttttt tgtattttta gtagagatgg ggtttcacca tgttggtgaa gctggtcttg    14700

aactcctggg ctcaagtgat ccacccacct cggcttccca aagtgctggg attacaggtg    14760

tgagccactg tgcccagcct cattttctaa cctttgatct catgtccagc cctgtcactt    14820

catttcttgt tagagaattt gaccgcctaa cacatgattc catttccttg tatatgtcat    14880

ctgtatagga agaaaacctc ttttttattt tcattcaaca cttctggcca ccaaacaggt    14940

gtgggagtgt tttctaagca attctccagt tatctgggga caccaactgg gtgtcctaca    15000

attgaatcca attctaacac tctacctgga aataacatca gatcccgtgc agtttaagtg    15060

ctccgcccca gcaaatttcc ccccgtttcc aatgtcagtt acaagactgg gttgtcacct    15120

gtgcatcaga ccaaccagct ataatttgga gattcccaca actccctgct agggtttcat    15180

catttgctag aatagctgac aaaactcagg agacacttac atttactggt ttattatgta    15240

aaggattaag taaaggatac agatgaacag ccagttgaag agatacatag ggcaaaatct    15300

ggaagggtcc tgggcccagc agcatctatc ctgtggagtt ctgtttgcta ccttcctgac    15360

acatgtatgt gttcaccaac cagaaactct cagaaccctg tactttagga gaagtcatca    15420

tgtaggcatg attgattatt acccaatctc cagctcctct cttctcccca gaggatggag    15480

agaggggctg aaagttccaa gcttctaatc acacttggtc tttctggtga ccagccccaa    15540

tccaggagcc agcaggagta gcctcattag cacaaaaggc attcctatga cccaggaaat    15600

tccaagggat ctagtagctc tgtgtcagga actgggatcg gagaccaaat attagatggt    15660

ctaatatttg gagctaaaga tgctcctata gcatattttc ccattatttc acagcatcat    15720

ggcattgcat ataacctcat tttttcatat atgacctatc tctgatctat tacctcacct    15780

ccaaggtcct gggagataag gaggcaatga catcattttt cagggttgtt ttagggatga    15840

ggggcaaggc ctctcacctt gagagagagt ggcagtgttg ggcccactaa tagaggatcc    15900

cacgaactgc cagagggtac agtatgtaat ctggcaaaca agggaagagg aagagagcac    15960

tgggactcag gatgaaccca gagaattcag gacaaaggtc tccatcagct gagggtatca    16020

tgctggcttc tgactctgtt tttctctggt tttgccctag aattcttcga tttttcttat    16080

gaccttaacc tgtgtgggct gacagaggac ccagatcttc aggtttctgc gatgcagcac    16140

cagacagtgc tggaactgac agagactggg gtggaggcgg ctgcagcctc cgccatctct    16200

gtggcccgca ccctgctggt ctttgaagtg cagcagccct tcctcttcgt gctctgggac    16260

cagcagcaca agttccctgt cttcatgggg cgagtatatg accccagggc ctgagacctg    16320

caggatcagg ttagggcgag cgctacctct ccagcctcag ctctcagttg cagccctgct    16380

gctgcctgcc tggacttggc ccctgccacc tcctgcctca ggtgtccgct atccaccaaa    16440

agggctccct gagggtctgg gcaagggacc tgcttctatt agcccttctc catggccctg    16500

ccatgctctc caaaccactt tttgcagctt tctctagttc aagttcacca gactctataa    16560

ataaaacctg acagaccatg actttctctg ctttgccttt gtttttttat tttttatttt    16620

ttattttttt taggcagggt ctcaatctgt cacccaggct agagtacagt ggtgagatca    16680

tggttcactg cagccttaac ctcctgagct caaacaatcc tcccatctca gcctcctatg    16740

taggtgggac cacatgggct tgccaccatg cccagctaat ttttaaattt tttgtaaaga    16800

cagggtctta ctatgttgcc taggctggtc tccaactcct gggctcaagc aatcatccta    16860

acacagcctc ccgaagtgct gggattgtag gcacaccata cctctccttt gcctttgaat    16920

atcagctgct tcaatactaa aggacaagag cgcccatggt tcctgtatca gccagctatt    16980

gctgtatagt aagtcacgtt aaacttagtg gcttcaaaca gcaacccttt gttattttat    17040

gtaagtttca gagttgacta ggtgttttgc tgatctgggc tgaacctggc tgatcttccc    17100

tgggctcatt catacatctg taaggtatag ttgttgggtt ggttagggga tgactggtct    17160

tctgtggcct cagccatgac accaggacaa cttggctctt ctacatgtct tgtatgtcct    17220

tccaacaggc tagtctgtaa tggaaaagag tcaaacagcc agtctctttt tgtttaccat    17280

tgtcctgcag ccaaagcaaa tcacaggacc aaacctagag ttagactgga aaagcactac    17340

aaagtgacag ggcaaagaga cgttaattgg ggactattca tgcagtccat ttctcacagc    17400

ccctatcttg cttatttgtc tgcaacaact ctgacaacaa taatgacagt agctaacgtt    17460

gggaacatag gcagtctgct aagagttttg caggcattta atcttcacaa taaatttata    17520

tggtaaattc agagaggcta agtcttgttc aaagtcctgt agttaggaaa tgatgaaact    17580

gagatttaat agcacctctt atgactcttt tttttttgag acaaagtttc tcttttgttg    17640

ccaaggcttg agtataatag cacaatctcg gctcactgta acctctgcct cctgggttca    17700

agtgattctc ctgcctcagc ctcccaagta gctgggatta caagcatgca ctaccacacc    17760

tggctaattt tgtattttta gtagagacag gttttctttt tttttttttt tccgagatgg    17820

agtcttgctt tgtcggccag gctggagtgc agtggtgcaa tcttggctta ctcaacctcc    17880

acctcccggg ttcaagtagt tctgcctcag cctcccaagt agctgggatt acaggcgtgc    17940

accaccaagc ccagctaact tttgtatttt tagtagagac ggggtttcac catgtggacc    18000

aggctggtct caaactcctg actccaagtg atcttcccac ctcagcctcc caaagtgctg    18060

gcattacagg tgtgagccac tgtgcccggc ctagtgaaaa caatcttctt tactcagtct    18120

accagctcaa ataccagtct cttcaggaaa caacctcaca gacacaccca gaaatgatat    18180

cttaccagtt gtctgggcat cccttagccc agtaaaattg acacataaat ttaaccaccc    18240

cacaccttcc cttctcagtt tcccaaagtc aatctctcag gctgctggga agaccccaaa    18300

ttcctgtctg ggtgggtccc gctttgattc ttatgtgagg aactgttgaa agcaaaggca    18360

ccccccaaat tcaggaagat tcccctctcc ttggggagat cctgacatga tgaaggtggt    18420

gctcagcacc aacctgaatt gtgaaccaac aaagtcagga ggtggaaggt gattctgacc    18480

cctgtggggg tcaaatctct ttgacccttc caatcatgct gagcccggta atgttcccgt    18540

ttgtgaaatg atgaagccaa aactcagaga ggttaagtaa ctatccaaag gtcagactgc    18600

tgcaaatcga tcccacatta tccaaattca agtgtagtag ataacttatt tgggcaggct    18660

tatttccttt ctgcccaaac ttgactgtaa cttaaatctg tgtcttctta ctccctgcac    18720

catgtgaccc tacagagctt atcaaagtgt cttgcactta aaaaaaaaaa aactatggag    18780

gctgggcata gtggctcatg cctataatgc cagcactttg ggagacggag gcaggcagat    18840

cacttgaggc cagggttttg agaccagcct gggcaacatg gcgaaaccct gtctctatta    18900

aaaaatacaa aaatgagcca ggtgttgtgg tgcatgcctg taatcccagc tactcgggag    18960

gctgaggcat gagaatcact ttaacctgga aggcagaggt tgcagtgaat ccagattgta    19020

ccactccact ccagcctggg tgacagagtg agagactgtc taaaaaaaaa aactatgaaa    19080

tgaatgatta aatgaatgag ttatcacatc caggtagagg gaaagaggag atacctaccc    19140

atctggaaag catagaaaaa tctggaaatg aagagaattt atttatttat tttatttttt    19200

gagacagagt cttgctctat cacccaggct ggagtgcagc ggcttgaaca tggttcactg    19260

cagccttgac ctcctgggct caggtgatcc ttccacttca gcctcctgag tagcagggac    19320

cacaggtgtg caccaccaca cctggctaca ttttttgttt tttataaaga cagggtctca    19380

gctgggcacg gtggctcatg cctgtaatgc cagcactttg ggaggccaag gcaggctgat    19440

cacctgagct caggagttcg agaccagcct ggcccacatg gtgaaacctc gtctctatta    19500

aaaatacaaa aattaacaag gcgtggcagc aggcacatgt aatcccagct acttgcgggc    19560

tgaggcagga gaatcacttg aacccaagag gtggaggttg cagtgagccg agatcatgcc    19620

actgcactcc tccagtctgg gggatggagc aagacttcgc cttggagaaa aaaaaaaaaa    19680

gtctcactgt gttgcccaag ctggtctgga actcctgggc tcaagagatc ctctagcctt    19740

ggcctcccaa aatgttggga ttactggtgt gagccaccac acccaagata atttaaatat    19800

tttctcttct gaagcttttc ttataagagg gcatgtgtca cttttttcgt ttgtttaaaa    19860

caatgaacat ttattttgct ttgttttggt tttttgtttt tgtttttgtt ttgagacgga    19920

gtcttgctct gtcttgccca ggctggagta cagtgacaca atctcggctc actgcagcct    19980

ccgcctcctg ggttcaaaca attctcctgt ctcagcctcc cgagtagctg ggactacagg    20040

cttgtgccac catgcctagc taatttttgt atctttagta gaaacgaggt ttcactatgt    20100

tggccaggct ggtctcgaac tcctgacctc aggtgacctg ccctccttgg ccccccaaag    20160

tgccgggatt acaggtataa gccactgcac ccagcctgaa catttatttt gctaatgagt    20220

cattgaccca gtgtgggctt ggcaaatcta gggtagcctc agttatgtac ctgctacagt    20280

cagctggggg ttagctgaag gtttgttgag gtttgatttc actgagcttg cataggctct    20340

ttcacatgtt ttagactttg gctgggatca accagatgac caattctgat ccaagtgatc    20400

tctggtcttc caggaagcta gtctggctta ttcatacgaa gtttgcaaaa gtccaagaaa    20460

gcaagcagag gcatgcatgc aaggcctctt gaatccgaag ctaggaacta ctagaacatc    20520

acttctgcct cattctagca gccaaagcaa gtcaccagac cagtttagat tcaaggtaag    20580

gaaagaatct ctacctgtta aagaaaagac ctgcaaagtc attctgctaa gggcattaat    20640

ataacgaaat gtgaataatt ctggccactt ttccagtata ccatatgtgg tcttacatag    20700

ttgcaaacaa ctattagcaa ctttccccag caacctgcca ctctgttttt ccctaaagaa    20760

tcaagggctt ttgtcgagat cataataata ttagaaacac tttgttacat gaagtttcaa    20820

gtcgtttgca tataaattga atcttctgtt gctatctctg tggcatattt aacaatctct    20880

ggctcttcca gctgcctgtg ttgtagaata aattattata aatacagagc tgcctgagta    20940

tttataataa taaataaata aattatcttc atttccattt cccttgagaa agatggacag    21000

agggctatgc actcatagac acacacacac acacacacac acacaccctt acaaccccca    21060

cctttctgcc ctgccttgca attctactct ggggtagaca aaggcctgta tgtccacaga    21120

tccattttca gtgatctgtt tcctgtcccc aactgtagac ccctccacac gtggatttgt    21180

ctggggaaga accttaaggt gagattaggg ttccattgca atgagtcttt gctgccactt    21240

ggtgtcattg ttgaaggctt gtcctgcata gccccatgga cacttgcctt ttcagggaga    21300

tgtttttgct gttccagatt cttttttttt tttttttttg agacagaatc tctctctgtt    21360

gcccagactg gagtgcaatg gtgcgatctt ggctcactgc aacctctgtt tcccaggttg    21420

aagggattct cctgcctcag cttcctgagt agcaggaatt ataggcaccc accatgtgtc    21480

cagctaattt ttgtattttt agtagagatg gggttttacc atgttggcca ggctggtctc    21540

aaactcctga cctcaagtga tccacccatc ttggcctccc aaagtgttag aattacaggt    21600

gtgagtcact gtgcctggcc ggttccagat tcttaaacag ctgatgtggg gacttaaact    21660

ttgattccaa agtttacact ttacacttgt tcagccactg tttctcaaag atcaatacct    21720

ttagttctct ctggatagca gaaggcttcc aacatgagcc ataggctatg tcagaatcag    21780

cctcatccct atgaaccctt aggacattgt cttgactcat ggttgataac cacattagcc    21840

atgtatctac ctaacatgca ttaaccattt gccatgctgt caggcactgt gttaagaatt    21900

ttacatggat tatgttattt catttaagag agatcatgac ttaagaaaag gatatgttac    21960

tgaatatatt agataattca aaatttagat aatttgatac taagttttcc agaataataa    22020

ctgtaaaagg tagggagaga atcttcaacc attgtagaat ttcttgtctt caaactattg    22080

tttattttct aaatacaaaa atctctaata tttctcagag taggcactct taaattaact    22140

gcttggcata tcaggacagc tatttgggct ttttcatagt gtcttatcat atctaacttt    22200

cattacaaag ttattgattt tggagggtgt ttttagcact agt                      22243


<210>  3
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic AAB59490.1 (FactorXII - AA)

<400>  3

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Pro Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  4
<211>  1959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic M11723.1 (FactorXII - Nucleotide)

<400>  4
ttggagtcaa cactttcgat tccaccttgg gaagccccca aggagcataa gtacaaagct       60

gaagagcaca cagtcgttct cactgtcacc ggggagccct gccacttccc cttccagtac      120

caccggcagc tgtaccacaa atgtacccac aagggccggc caggccctca gccctggtgt      180

gctaccaccc ccaactttga tcaggaccag cgatggggat actgtttgga gcccaagaaa      240

gtgaaagacc actgcagcaa acacagcccc tgccagaaag gagggacctg tgtgaacatg      300

ccaagcggcc cccactgtct ctgtccacaa cacctcactg gaaaccactg ccagaaagag      360

aagtgctttg agcctcagct tctccggttt ttccacaaga atgagatatg gtatagaact      420

gagcaagcag ctgtggccag atgccagtgc aagggtcctg atgcccactg ccagcggctg      480

gccagccagg cctgccgcac caacccgtgc ctccatgggg gtcgctgcct agaggtggag      540

ggccaccgcc tgtgccactg cccggtgggc tacaccggac ccttctgcga cgtggacacc      600

aaggcaagct gctatgatgg ccgcgggctc agctaccgcg gcctggccag gaccacgctc      660

tcgggtgcgc cctgtcagcc gtgggcctcg gaggccacct accggaacgt gactgccgag      720

caagcgcgga actggggact gggcggccac gccttctgcc ggaacccgga caacgacatc      780

cgcccgtggt gcttcgtgct gaaccgcgac cggctgagct gggagtactg cgacctggca      840

cagtgccaga ccccaaccca ggcggcgcct ccgaccccgg tgtcccctag gcttcatgtc      900

ccactcatgc ccgcgcagcc ggcaccgccg aagcctcagc ccacgacccg gaccccgtct      960

cagtcccaga ccccgggagc cttgccggcg aagcgggagc agccgccttc cctgaccagg     1020

aacggcccac tgagctgcgg gcagcggctc cgcaagagtc tgtcttcgat gacccgcgtc     1080

gttggcgggc tggtggcgct acgcggggcg cacccctaca tcgccgcgct gtactggggc     1140

cacagtttct gcgccggcag cctcatcgcc ccctgctggg tgctgacggc cgctcactgc     1200

ctgcaggacc ggcccgcacc cgaggatctg acggtggtgc tcggccagga acgccgtaac     1260

cacagctgtg agccgtgcca gacgttggcc gtgcgctcct accgcttgca cgaggccttc     1320

tcgcccgtca gctaccagca cgacctggct ctgttgcgcc ttcaggagga tgcggacggc     1380

agctgcgcgc tcctgtcgcc ttacgttcag ccggtgtgcc tgccaagcgg cgccgcgcga     1440

ccctccgaga ccacgctctg ccaggtggcc ggctggggcc accagttcga gggggcggag     1500

gaatatgcca gcttcctgca ggaggcgcag gtaccgttcc tctccctgga gcgctgctca     1560

gccccggacg tgcacggatc ctccatcctc cccggcatgc tctgcgcagg gttcctcgag     1620

ggcggcaccg atgcgtgcca gggtgattcc ggaggcccgc tggtgtgtga ggaccaagct     1680

gcagagcgcc ggctcaccct gcaaggcatc atcagctggg gatcgggctg tggtgaccgc     1740

aacaagccag gcgtctacac cgatgtggcc tactacctgg cctggatccg ggagcacacc     1800

gtttcctgat tgctcaggga ctcatctttc cctccttggt gattccgcag tgagagagtg     1860

gctggggcat ggaaggcaag attgtgtccc attcccccag tgcggccagc tccgcgccag     1920

gatggcgcag gaactcaata aagtgctttg aaaatgctg                            1959


