                         SEQUENCE LISTING

<110>  Taipei Medical University
       YEN, Yun
 
<120>  ANTIBODIES AGAINST GLYPICAN-3 AND THEIR USES IN CANCER DIAGNOSIS 
       AND TREATMENT

<130>  G4590-00200

<140>  PCT/US2016/034633
<141>  2016-05-27

<150>  US 62/166,760
<151>  2015-05-27

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Gly Phe Thr Phe Ser Ser Val Asn 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Gly Phe Thr Phe Ser Ser Phe Asn 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gly Phe Thr Phe Asn Asn Tyr Cys 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Val Ser Lys Asp Gly Thr Thr Thr 
1               5               


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Ile Ser Asn Thr Asn Thr Thr 
1               5           


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Ile Ser Ser Thr Gly Ser Arg Thr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Ile Ser Lys Asp Gly Ser Thr Pro 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Ile Ser Gly Thr Gly Ser Ser Thr 
1               5               


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Ala Lys Ser Asn Thr Asn Ser Arg Ala Ala Gly Leu Ile Asp Ala 
1               5                   10                  15  


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Ala Arg Gly Ser Gly Val Ser Gly Thr Tyr Ala Gly Gln Ile Asp Ala 
1               5                   10                  15      


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Ala Lys Ser Ala Ser Arg Gly Ala Gly Arg Ile Asp Ala 
1               5                   10              


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Ala Arg Gly Gly Gly Ser Asn Tyr Cys Gly Ser Thr Gly Arg Ile Asn 
1               5                   10                  15      


Ala 
    


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Ala Lys Gly Val Asp Ser Asp Ser Trp Thr Ala Ala Gly Ile Asp Ala 
1               5                   10                  15      


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Ser Gly Ser Tyr Gly 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Gly Gly Ser Tyr Gly 
1               5   


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Thr Gly Arg Trp Tyr Gly 
1               5       


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Gly Ser Arg Asp Ser Ser Tyr Val Gly Ile 
1               5                   10  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Gly Asn Tyr Asp Gly Asn Thr Asp Ser Gly Tyr Val Gly Val 
1               5                   10                  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Gly Ser Arg Asp Ser Ser Tyr Phe Gly Ile 
1               5                   10  


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gly Asn Ala Gly Ser Ser Thr Tyr Ala Gly Ile 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Gly Ser Arg Glu Ser Ser Arg Asn Pro Gly Ile 
1               5                   10      


<210>  23
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Val Ser Lys Asp Gly Thr Thr Thr Lys Tyr Gly Ser Ala Val 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Asn Thr Asn Ser Arg Ala Ala Gly Leu Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  24
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Thr Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Gly Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Val 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Asn Thr Asn Thr Thr Gly Tyr Ala Ala Ala Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Thr Arg Asp Asn Gly Gln Ser Thr Val Arg Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ser Gly Val Ser Gly Thr Tyr Ala Gly Gln Ile Asp Ala Trp 
            100                 105                 110         


Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120         


<210>  25
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Gly Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gln Ile Ser Ser Thr Gly Ser Arg Thr Tyr Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Asn Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ala Ser Arg Gly Ala Gly Arg Ile Asp Ala Trp Gly His 
            100                 105                 110         


Gly Thr Glu Val Ile Val Ser Ser 
        115                 120 


<210>  26
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Gly Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Gln Ile Ser Ser Thr Gly Ser Arg Thr Tyr Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ala Ser Arg Gly Ala Gly Arg Ile Asp Ala Trp Gly His 
            100                 105                 110         


Gly Thr Glu Val Ile Val Ser Ser 
        115                 120 


<210>  27
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Thr Leu Ser Leu Val Cys Lys Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Cys Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Lys Asp Gly Ser Thr Pro Tyr Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asp Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Asp Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Ser Asn Tyr Cys Gly Ser Thr Gly Arg Ile Asn 
            100                 105                 110         


Ala Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120                 


<210>  28
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Thr Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Leu Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Gly Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Glu Ile Ser Gly Thr Gly Ser Ser Thr Tyr Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val Arg 
65                  70                  75                  80  


Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Val Asp Ser Asp Ser Trp Thr Ala Ala Gly Ile Asp Ala 
            100                 105                 110         


Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
        115                 120             


<210>  29
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Val Ser Lys Asp Gly Thr Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Asn Thr Asn Ser Arg Ala Ala Gly Leu Ile Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  30
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Asn Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Ser Thr Gly Ser Arg Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Ala Ser Arg Gly Ala Gly Arg Ile Asp Ala Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Ser Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Leu Ile Tyr Ala Asn Thr Asn 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Val Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Arg Asp Ser Ser Tyr Val Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Ala Leu Thr Gln Pro Ser Leu Val Ser Ala Asn Leu Gly Gly Thr Ala 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Gly Ser Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Gln Asn Asp Lys 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Asn Tyr Asp Gly Asn Thr Asp Ser Gly Tyr Val Gly 
                85                  90                  95      


Val Phe Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105         


<210>  33
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile His Asn Asn Asn Asn 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Arg Asp Ser Ser Tyr Phe Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  34
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu Thr Val 
1               5                   10                  15      


Lys Ile Thr Cys Ser Gly Gly Gly Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile His Asn Asn Asn Asn 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr Gly Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gly Ser Arg Asp Ser Ser Tyr Phe Gly Ile Phe Gly Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  35
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Glu Ile Thr Cys Ser Gly Gly Ser Gly Ser Tyr Gly Trp His Gln Gln 
            20                  25                  30          


Lys Ser Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Arg Asn Asn Gln 
        35                  40                  45              


Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Lys Ser Gly Ser 
    50                  55                  60                  


Thr His Thr Leu Thr Ile Thr Gly Val Arg Ala Glu Asp Glu Ala Val 
65                  70                  75                  80  


Tyr Phe Cys Gly Asn Ala Gly Ser Ser Thr Tyr Ala Gly Ile Phe Gly 
                85                  90                  95      


Ala Gly Thr Thr Leu Thr Val Leu 
            100                 


<210>  36
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Leu Gly Gly Thr Val 
1               5                   10                  15      


Lys Ile Ser Cys Ser Gly Gly Thr Gly Arg Trp Tyr Gly Trp Tyr Gln 
            20                  25                  30          


Gln Lys Ser Pro Gly Ser Leu Pro Val Thr Val Ile Tyr Ser Asn Asp 
        35                  40                  45              


Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser Gly 
    50                  55                  60                  


Ser Thr Ser Thr Leu Thr Ile Thr Gly Val Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Val Tyr Phe Cys Gly Ser Arg Glu Ser Ser Arg Asn Pro Gly Ile Phe 
                85                  90                  95      


Gly Ala Gly Thr Thr Leu Thr Val Leu 
            100                 105 


<210>  37
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Glu Leu Ala Leu Ile Gln Pro Ala Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Ser Gly Ser Tyr Gly Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Ala 
        35                  40                  45              


Asn Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    50                  55                  60                  


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Gly Ser Arg Asp Ser Ser Tyr Val Gly Ile 
                85                  90                  95      


Phe Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105     


<210>  38
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser Ile 
1               5                   10                  15      


Thr Ile Ser Cys Thr Gly Thr Gly Gly Ser Tyr Gly Trp Tyr Gln Gln 
            20                  25                  30          


His Ala Gly Lys Ala Pro Lys Leu Val Ile Tyr Asn Asn Asn Lys Arg 
        35                  40                  45              


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
    50                  55                  60                  


Ala Ser Leu Thr Val Ser Gly Leu Gln Thr Asp Asp Glu Ala Val Tyr 
65                  70                  75                  80  


Tyr Cys Gly Ser Arg Asp Ser Ser Tyr Phe Gly Ile Phe Gly Gly Gly 
                85                  90                  95      


Thr Lys Leu Thr Val Leu 
            100         


