                         SEQUENCE LISTING

<110>  Universit degli Studi del Piemonte Orientale "Amedeo 
       Avogadro"
 
<120>  Ligands of B7h receptor in the treatment of osteopenia and 
       osteoporosis

<130>  BWO18189-CF

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  380
<212>  PRT
<213>  artificial

<220>
<223>  ICOS-Fc

<400>  1

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Gly Ala His Ala Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Ala Ser Asp Lys Thr His Thr Cys Pro 
    130                 135                 140                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                165                 170                 175     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            180                 185                 190         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        195                 200                 205             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    210                 215                 220                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
225                 230                 235                 240 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                245                 250                 255     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            260                 265                 270         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        275                 280                 285             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    290                 295                 300                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
305                 310                 315                 320 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                325                 330                 335     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            340                 345                 350         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Thr Ser Gly Lys 
        355                 360                 365             


Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
    370                 375                 380 


<210>  2
<211>  115
<212>  PRT
<213>  homo sapiens

<400>  2

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu 
        115 


<210>  3
<211>  227
<212>  PRT
<213>  homo sapiens

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  375
<212>  PRT
<213>  artificial

<220>
<223>  ICOS-msFC

<400>  4

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Gly Ala His Ala Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Ala Ser Gly Cys Lys Pro Cys Ile Cys 
    130                 135                 140                 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
            180                 185                 190         


Asp Val Glu Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Ile 
        195                 200                 205             


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
                245                 250                 255     


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
            260                 265                 270         


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu Asp 
        275                 280                 285             


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
    290                 295                 300                 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
305                 310                 315                 320 


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
                325                 330                 335     


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
            340                 345                 350         


Leu Ser His Ser Pro Gly Lys Thr Ser Gly Lys Pro Ile Pro Asn Pro 
        355                 360                 365             


Leu Leu Gly Leu Asp Ser Thr 
    370                 375 


<210>  5
<211>  222
<212>  PRT
<213>  mus musculus

<400>  5

Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
1               5                   10                  15      


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            20                  25                  30          


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu 
65                  70                  75                  80  


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                85                  90                  95      


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        115                 120                 125             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    130                 135                 140                 


Thr Asn Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
145                 150                 155                 160 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
                165                 170                 175     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            180                 185                 190         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        195                 200                 205             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220         


<210>  6
<211>  380
<212>  PRT
<213>  artificial

<220>
<223>  F119S - ICOS-Fc

<400>  6

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Gly Ala His Ala Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Ser Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Ala Ser Asp Lys Thr His Thr Cys Pro 
    130                 135                 140                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                165                 170                 175     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            180                 185                 190         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        195                 200                 205             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    210                 215                 220                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
225                 230                 235                 240 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                245                 250                 255     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            260                 265                 270         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        275                 280                 285             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    290                 295                 300                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
305                 310                 315                 320 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                325                 330                 335     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            340                 345                 350         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Thr Ser Gly Lys 
        355                 360                 365             


Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
    370                 375                 380 


<210>  7
<211>  115
<212>  PRT
<213>  artificial

<220>
<223>  F119S mutated ICOS

<400>  7

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Ser Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu 
        115 


<210>  8
<211>  8
<212>  DNA
<213>  artificial

<220>
<223>  Kozak sequence

<400>  8
ccacatgg                                                                 8


<210>  9
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  secretory leader sequence

<400>  9
gctggagcct gatcctcctg ttcctcgtcg ctgtggctac a                           41


<210>  10
<211>  82
<212>  DNA
<213>  artificial

<220>
<223>  mini intron sequence

<400>  10
gtaaggggct cacagtagca ggcttgaggt ctggacatat atatgggtga caatgacatc       60

cactttgcct ttctctccac ag                                                82


<210>  11
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  SV5 tag

<400>  11
ggcaaaccaa tcccaaaccc actgctgggc ctggatagta ct                          42


<210>  12
<211>  345
<212>  DNA
<213>  homo sapiens

<400>  12
gaaatcaatg gttctgccaa ttatgagatg tttatatttc acaacggagg tgtacaaatt       60

ttatgcaaat atcctgacat tgtccagcaa tttaaaatgc agttgctgaa aggggggcaa      120

atactctgcg atctcactaa gacaaaagga agtggaaaca cagtgtccat taagagtctg      180

aaattctgcc attctcagtt atccaacaac agtgtctctt tttttctata caacttggac      240

cattctcatg ccaactatta cttctgcaac ctatcaattt ttgatcctcc tccttttaaa      300

gtaactctta caggaggata tttgcatatt tatgaatcac aactt                      345


<210>  13
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  ICOS forward BsshII primer

<400>  13
ggcgcgcatg ccgaaatcaa tggttctgcc                                        30


<210>  14
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  ICOS reverse NheI primer

<400>  14
gctagcaagt tgtgattcat aaatatgc                                          28


<210>  15
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  mutation F119S - forward primer

<400>  15
tcaatttttg atcctcctcc ttctaaagta actcttacag g                           41


<210>  16
<211>  375
<212>  DNA
<213>  mus musculus

<400>  16
gaaatcaatg gctcggccga tcataggatg ttttcatttc acaatggagg tgtacagatt       60

tcttgtaaat accctgagac tgtccagcag ttaaaaatgc gattgttcag agagagagaa      120

gtcctctgcg aactcaccaa gaccaaggga agcggaaatg cggtgtccat caagaatcca      180

atgctctgtc tatatcatct gtcaaacaac agcgtctctt ttttcctaaa caacccagac      240

agctcccagg gaagctatta cttctgcagc ctgtccattt ttgacccacc tccttttcaa      300

gaaaggaacc ttagtggagg atatttgcat atttatgaat cccagctctg ctgctgccag      360

ctgaagctct ggcta                                                       375


<210>  17
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  ICOS mouse forward BsshII primer

<400>  17
ttggcgcgca tgccgaaatc aatggctcgg ccgatc                                 36


<210>  18
<211>  29
<212>  DNA
<213>  artificial

<220>
<223>  ICOS mouse reverse NheI primer

<400>  18
ctagctagct agccagagct tcagctggc                                         29


<210>  19
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  P-Hygro sense primer

<400>  19
ctgcttactg gcttatcg                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  P-Hygro antisense primer

<400>  20
cagatggctg gcaactag                                                     18


<210>  21
<211>  6729
<212>  DNA
<213>  artificial

<220>
<223>  expression vector for ICOS-Fc

<400>  21
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctgtctaga      900

tgccaccatg ggctggagcc tgatcctcct gttcctcgtc gctgtggcta caggtaaggg      960

gctcacagta gcaggcttga ggtctggaca tatatatggg tgacaatgac atccactttg     1020

cctttctctc cacaggtggc gcgcatgccg aaatcaatgg ttctgccaat tatgagatgt     1080

ttatatttca caacggaggt gtacaaattt tatgcaaata tcctgacatt gtccagcaat     1140

ttaaaatgca gttgctgaaa ggggggcaaa tactctgcga tctcactaag acaaaaggaa     1200

gtggaaacac agtgtccatt aagagtctga aattctgcca ttctcagtta tccaacaaca     1260

gtgtctcttt ttttctatac aacttggacc attctcatgc caactattac ttctgcaacc     1320

tatcaatttt tgatcctcct ccttttaaag taactcttac aggaggatat ttgcatattt     1380

atgaatcaca acttgctagc gacaaaactc acacatgccc accgtgccca gcacctgaac     1440

tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct     1500

cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca     1560

agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag ccgcgggagg     1620

agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac caggactggc     1680

tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga     1740

aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat     1800

cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa ggcttctatc     1860

ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca     1920

cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc accgtggaca     1980

agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca     2040

accactacac gcagaagagc ctctccctgt ccccgggtaa aactagtggc aaaccaatcc     2100

caaacccact gctgggcctg gatagtactt aaaagcttaa acccgctgat cagcctcgac     2160

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     2220

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     2280

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     2340

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag     2400

aaccagctgg ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc     2460

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     2520

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     2580

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     2640

tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     2700

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     2760

ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt     2820

aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag     2880

ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc     2940

aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa     3000

agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc     3060

ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat     3120

gcagaggccg aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt     3180

ggaggcctag gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat     3240

cagcacgtga tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa     3300

aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc     3360

agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc     3420

tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg     3480

cttgacattg gggaattcag cgagagcctg acctattgca tctcccgccg tgcacagggt     3540

gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag     3600

gccatggatg cgatcgctgc ggccgatctt agccagacga gcgggttcgg cccattcgga     3660

ccgcaaggaa tcggtcaata cactacatgg cgtgatttca tatgcgcgat tgctgatccc     3720

catgtgtatc actggcaaac tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct     3780

ctcgatgagc tgatgctttg ggccgaggac tgccccgaag tccggcacct cgtgcacgcg     3840

gatttcggct ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg     3900

agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg     3960

tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca     4020

ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc     4080

ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc     4140

cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg     4200

accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg     4260

agggcaaagg aatagcacgt gctacgagat ttcgattcca ccgccgcctt ctatgaaagg     4320

ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga tcctccagcg cggggatctc     4380

atgctggagt tcttcgccca ccccaacttg tttattgcag cttataatgg ttacaaataa     4440

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     4500

ttgtccaaac tcatcaatgt atcttatcat gtctgtatac cgtcgacctc tagctagagc     4560

ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     4620

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     4680

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     4740

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     4800

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     4860

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     4920

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     4980

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     5040

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     5100

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     5160

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     5220

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     5280

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     5340

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     5400

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     5460

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggttttttt     5520

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     5580

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     5640

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     5700

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     5760

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     5820

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     5880

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     5940

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     6000

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     6060

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     6120

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     6180

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     6240

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     6300

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     6360

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     6420

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     6480

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     6540

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     6600

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     6660

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     6720

cctgacgtc                                                             6729


<210>  22
<211>  6714
<212>  DNA
<213>  artificial

<220>
<223>  expression vector coding for ICOS-msFc

<400>  22
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctgtctaga      900

tgccaccatg ggctggagcc tgatcctcct gttcctcgtc gctgtggcta caggtaaggg      960

gctcacagta gcaggcttga ggtctggaca tatatatggg tgacaatgac atccactttg     1020

cctttctctc cacaggtggc gcgcatgccg aaatcaatgg ttctgccaat tatgagatgt     1080

ttatatttca caacggaggt gtacaaattt tatgcaaata tcctgacatt gtccagcaat     1140

ttaaaatgca gttgctgaaa ggggggcaaa tactctgcga tctcactaag acaaaaggaa     1200

gtggaaacac agtgtccatt aagagtctga aattctgcca ttctcagtta tccaacaaca     1260

gtgtctcttt ttttctatac aacttggacc attctcatgc caactattac ttctgcaacc     1320

tatcaatttt tgatcctcct ccttttaaag taactcttac aggaggatat ttgcatattt     1380

atgaatcaca acttgctagc ggttgtaagc cttgcatatg tacagtccca gaagtatcat     1440

ctgtcttcat cttcccccca aagcccaagg atgtgctcac cattactctg actcctaagg     1500

tcacgtgtgt tgtggtagac atcagcaagg atgatcccga ggtccagttc agctggtttg     1560

tagatgatgt ggaggtgcac acagctcaga cgaaaccccg ggaggagcag atcaacagca     1620

ctttccgttc agtcagtgaa cttcccatca tgcaccagga ctggctcaat ggcaaggagt     1680

tcaaatgcag ggtcaacagt gcagctttcc ctgcccccat cgagaaaacc atctccaaaa     1740

ccaaaggcag accgaaggct ccacaggtgt acaccattcc acctcccaag gagcagatgg     1800

ccaaggataa agtcagtctg acctgcatga taacaaactt cttccctgaa gacattactg     1860

tggagtggca gtggaatggg cagccagcgg agaactacaa gaacactcag cccatcatgg     1920

acacagatgg ctcttacttc gtctacagca agctcaatgt gcagaagagc aactgggagg     1980

caggaaatac tttcacctgc tctgtgttac atgagggcct gcacaaccac catactgaga     2040

agagcctctc ccactctcct ggtaaaacta gtggcaaacc aatcccaaac ccactgctgg     2100

gcctggatag tacttaaaag cttaaacccg ctgatcagcc tcgactgtgc cttctagttg     2160

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     2220

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     2280

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     2340

gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc     2400

tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac     2460

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc     2520

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt     2580

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg     2640

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     2700

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta     2760

ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat     2820

ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag     2880

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc     2940

aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     3000

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     3060

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     3120

gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     3180

tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcagca cgtgatgaaa     3240

aagcctgaac tcaccgcgac gtctgtcgag aagtttctga tcgaaaagtt cgacagcgtc     3300

tccgacctga tgcagctctc ggagggcgaa gaatctcgtg ctttcagctt cgatgtagga     3360

gggcgtggat atgtcctgcg ggtaaatagc tgcgccgatg gtttctacaa agatcgttat     3420

gtttatcggc actttgcatc ggccgcgctc ccgattccgg aagtgcttga cattggggaa     3480

ttcagcgaga gcctgaccta ttgcatctcc cgccgtgcac agggtgtcac gttgcaagac     3540

ctgcctgaaa ccgaactgcc cgctgttctg cagccggtcg cggaggccat ggatgcgatc     3600

gctgcggccg atcttagcca gacgagcggg ttcggcccat tcggaccgca aggaatcggt     3660

caatacacta catggcgtga tttcatatgc gcgattgctg atccccatgt gtatcactgg     3720

caaactgtga tggacgacac cgtcagtgcg tccgtcgcgc aggctctcga tgagctgatg     3780

ctttgggccg aggactgccc cgaagtccgg cacctcgtgc acgcggattt cggctccaac     3840

aatgtcctga cggacaatgg ccgcataaca gcggtcattg actggagcga ggcgatgttc     3900

ggggattccc aatacgaggt cgccaacatc ttcttctgga ggccgtggtt ggcttgtatg     3960

gagcagcaga cgcgctactt cgagcggagg catccggagc ttgcaggatc gccgcggctc     4020

cgggcgtata tgctccgcat tggtcttgac caactctatc agagcttggt tgacggcaat     4080

ttcgatgatg cagcttgggc gcagggtcga tgcgacgcaa tcgtccgatc cggagccggg     4140

actgtcgggc gtacacaaat cgcccgcaga agcgcggccg tctggaccga tggctgtgta     4200

gaagtactcg ccgatagtgg aaaccgacgc cccagcactc gtccgagggc aaaggaatag     4260

cacgtgctac gagatttcga ttccaccgcc gccttctatg aaaggttggg cttcggaatc     4320

gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct ggagttcttc     4380

gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca     4440

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc     4500

aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc gtaatcatgg     4560

tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc     4620

ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg     4680

ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaatgaatc     4740

ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact     4800

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     4860

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     4920

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     4980

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     5040

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     5100

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     5160

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     5220

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     5280

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     5340

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     5400

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     5460

agctcttgat ccggcaaaca aaccaccgct ggtagcggtt tttttgtttg caagcagcag     5520

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     5580

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     5640

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     5700

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     5760

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     5820

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca     5880

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     5940

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     6000

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg     6060

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc     6120

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg     6180

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca     6240

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt     6300

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc     6360

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc     6420

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca     6480

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa     6540

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat     6600

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     6660

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtc           6714


<210>  23
<211>  6729
<212>  DNA
<213>  artificial

<220>
<223>  expression vector coding for F119SICOS-Fc

<400>  23
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctgtctaga      900

tgccaccatg ggctggagcc tgatcctcct gttcctcgtc gctgtggcta caggtaaggg      960

gctcacagta gcaggcttga ggtctggaca tatatatggg tgacaatgac atccactttg     1020

cctttctctc cacaggtggc gcgcatgccg aaatcaatgg ttctgccaat tatgagatgt     1080

ttatatttca caacggaggt gtacaaattt tatgcaaata tcctgacatt gtccagcaat     1140

ttaaaatgca gttgctgaaa ggggggcaaa tactctgcga tctcactaag acaaaaggaa     1200

gtggaaacac agtgtccatt aagagtctga aattctgcca ttctcagtta tccaacaaca     1260

gtgtctcttt ttttctatac aacttggacc attctcatgc caactattac ttctgcaacc     1320

tatcaatttt tgatcctcct ccttctaaag taactcttac aggaggatat ttgcatattt     1380

atgaatcaca acttgctagc gacaaaactc acacatgccc accgtgccca gcacctgaac     1440

tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct     1500

cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca     1560

agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag ccgcgggagg     1620

agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac caggactggc     1680

tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga     1740

aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat     1800

cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa ggcttctatc     1860

ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca     1920

cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc accgtggaca     1980

agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca     2040

accactacac gcagaagagc ctctccctgt ccccgggtaa aactagtggc aaaccaatcc     2100

caaacccact gctgggcctg gatagtactt aaaagcttaa acccgctgat cagcctcgac     2160

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     2220

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     2280

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     2340

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag     2400

aaccagctgg ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc     2460

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     2520

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     2580

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     2640

tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     2700

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     2760

ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt     2820

aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag     2880

ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc     2940

aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa     3000

agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc     3060

ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat     3120

gcagaggccg aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt     3180

ggaggcctag gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat     3240

cagcacgtga tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa     3300

aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc     3360

agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc     3420

tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg     3480

cttgacattg gggaattcag cgagagcctg acctattgca tctcccgccg tgcacagggt     3540

gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag     3600

gccatggatg cgatcgctgc ggccgatctt agccagacga gcgggttcgg cccattcgga     3660

ccgcaaggaa tcggtcaata cactacatgg cgtgatttca tatgcgcgat tgctgatccc     3720

catgtgtatc actggcaaac tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct     3780

ctcgatgagc tgatgctttg ggccgaggac tgccccgaag tccggcacct cgtgcacgcg     3840

gatttcggct ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg     3900

agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg     3960

tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca     4020

ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc     4080

ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc     4140

cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg     4200

accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg     4260

agggcaaagg aatagcacgt gctacgagat ttcgattcca ccgccgcctt ctatgaaagg     4320

ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga tcctccagcg cggggatctc     4380

atgctggagt tcttcgccca ccccaacttg tttattgcag cttataatgg ttacaaataa     4440

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     4500

ttgtccaaac tcatcaatgt atcttatcat gtctgtatac cgtcgacctc tagctagagc     4560

ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     4620

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     4680

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     4740

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     4800

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     4860

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     4920

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     4980

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     5040

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     5100

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     5160

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     5220

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     5280

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     5340

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     5400

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     5460

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggttttttt     5520

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     5580

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     5640

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     5700

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     5760

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     5820

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     5880

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     5940

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     6000

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     6060

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     6120

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     6180

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     6240

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     6300

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     6360

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     6420

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     6480

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     6540

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     6600

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     6660

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     6720

cctgacgtc                                                             6729


<210>  24
<211>  389
<212>  PRT
<213>  artificial

<220>
<223>  msICOS-huFc

<400>  24

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Gly Ala His Ala Glu Ile Asn Gly Ser Ala Asp His Arg Met Phe Ser 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Ser Cys Lys Tyr Pro Glu Thr Val 
        35                  40                  45              


Gln Gln Leu Lys Met Arg Leu Phe Arg Glu Arg Glu Val Leu Cys Glu 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Ala Val Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Met Leu Cys Leu Tyr His Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Asn Asn Pro Asp Ser Ser Gln Gly Ser Tyr Tyr Phe Cys Ser Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Glu Arg Asn Leu Ser Gly Gly Tyr 
        115                 120                 125             


Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu 
    130                 135                 140                 


Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            180                 185                 190         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        195                 200                 205             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    210                 215                 220                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
225                 230                 235                 240 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                245                 250                 255     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            260                 265                 270         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        275                 280                 285             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    290                 295                 300                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
305                 310                 315                 320 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                325                 330                 335     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            340                 345                 350         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        355                 360                 365             


Leu Ser Pro Gly Lys Thr Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu 
    370                 375                 380                 


Gly Leu Asp Ser Thr 
385                 


<210>  25
<211>  6756
<212>  DNA
<213>  artificial

<220>
<223>  expression vector coding for msICOS-huFc

<400>  25
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctgtctaga      900

tgccaccatg ggctggagcc tgatcctcct gttcctcgtc gctgtggcta caggtaaggg      960

gctcacagta gcaggcttga ggtctggaca tatatatggg tgacaatgac atccactttg     1020

cctttctctc cacaggtggc gcgcatgccg aaatcaatgg ctcggccgat cataggatgt     1080

tttcatttca caatggaggt gtacagattt cttgtaaata ccctgagact gtccagcagt     1140

taaaaatgcg attgttcaga gagagagaag tcctctgcga actcaccaag accaagggaa     1200

gcggaaatgc ggtgtccatc aagaatccaa tgctctgtct atatcatctg tcaaacaaca     1260

gcgtctcttt tttcctaaac aacccagaca gctcccaggg aagctattac ttctgcagcc     1320

tgtccatttt tgacccacct ccttttcaag aaaggaacct tagtggagga tatttgcata     1380

tttatgaatc ccagctctgc tgccagctga agctctggct agctagcgac aaaactcaca     1440

catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc     1500

caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg     1560

acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc     1620

ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg     1680

tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca     1740

acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg cagccccgag     1800

aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac caggtcagcc     1860

tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg gagagcaatg     1920

ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac ggctccttct     1980

tcctctatag caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat     2040

gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc tccctgtccc     2100

cgggtaaaac tagtggcaaa ccaatcccaa acccactgct gggcctggat agtacttaaa     2160

agcttaaacc cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg     2220

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2280

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     2340

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt     2400

gggctctatg gcttctgagg cggaaagaac cagctggggc tctagggggt atccccacgc     2460

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac     2520

acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt     2580

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc     2640

tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc     2700

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact     2760

cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg     2820

gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc     2880

gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg ctccccagca     2940

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca     3000

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc     3060

ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc     3120

catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta     3180

ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga     3240

gcttgtatat ccattttcgg atctgatcag cacgtgatga aaaagcctga actcaccgcg     3300

acgtctgtcg agaagtttct gatcgaaaag ttcgacagcg tctccgacct gatgcagctc     3360

tcggagggcg aagaatctcg tgctttcagc ttcgatgtag gagggcgtgg atatgtcctg     3420

cgggtaaata gctgcgccga tggtttctac aaagatcgtt atgtttatcg gcactttgca     3480

tcggccgcgc tcccgattcc ggaagtgctt gacattgggg aattcagcga gagcctgacc     3540

tattgcatct cccgccgtgc acagggtgtc acgttgcaag acctgcctga aaccgaactg     3600

cccgctgttc tgcagccggt cgcggaggcc atggatgcga tcgctgcggc cgatcttagc     3660

cagacgagcg ggttcggccc attcggaccg caaggaatcg gtcaatacac tacatggcgt     3720

gatttcatat gcgcgattgc tgatccccat gtgtatcact ggcaaactgt gatggacgac     3780

accgtcagtg cgtccgtcgc gcaggctctc gatgagctga tgctttgggc cgaggactgc     3840

cccgaagtcc ggcacctcgt gcacgcggat ttcggctcca acaatgtcct gacggacaat     3900

ggccgcataa cagcggtcat tgactggagc gaggcgatgt tcggggattc ccaatacgag     3960

gtcgccaaca tcttcttctg gaggccgtgg ttggcttgta tggagcagca gacgcgctac     4020

ttcgagcgga ggcatccgga gcttgcagga tcgccgcggc tccgggcgta tatgctccgc     4080

attggtcttg accaactcta tcagagcttg gttgacggca atttcgatga tgcagcttgg     4140

gcgcagggtc gatgcgacgc aatcgtccga tccggagccg ggactgtcgg gcgtacacaa     4200

atcgcccgca gaagcgcggc cgtctggacc gatggctgtg tagaagtact cgccgatagt     4260

ggaaaccgac gccccagcac tcgtccgagg gcaaaggaat agcacgtgct acgagatttc     4320

gattccaccg ccgccttcta tgaaaggttg ggcttcggaa tcgttttccg ggacgccggc     4380

tggatgatcc tccagcgcgg ggatctcatg ctggagttct tcgcccaccc caacttgttt     4440

attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca     4500

tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc     4560

tgtataccgt cgacctctag ctagagcttg gcgtaatcat ggtcatagct gtttcctgtg     4620

tgaaattgtt atccgctcac aattccacac aacatacgag ccggaagcat aaagtgtaaa     4680

gcctggggtg cctaatgagt gagctaactc acattaattg cgttgcgctc actgcccgct     4740

ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa tcggccaacg cgcggggaga     4800

ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     4860

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     4920

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     4980

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     5040

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     5100

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     5160

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     5220

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     5280

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     5340

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     5400

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     5460

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     5520

caaaccaccg ctggtagcgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     5580

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     5640

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta     5700

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt     5760

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata     5820

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc     5880

agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac     5940

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag     6000

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac     6060

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc     6120

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg     6180

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc     6240

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct     6300

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc     6360

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc     6420

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc     6480

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc     6540

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca     6600

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt     6660

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt     6720

ccgcgcacat ttccccgaaa agtgccacct gacgtc                               6756


<210>  26
<211>  345
<212>  DNA
<213>  artificial

<220>
<223>  nucleotide sequence of the extracellular portion of human mutated
       F119SICOS

<400>  26
gaaatcaatg gttctgccaa ttatgagatg tttatatttc acaacggagg tgtacaaatt       60

ttatgcaaat atcctgacat tgtccagcaa tttaaaatgc agttgctgaa aggggggcaa      120

atactctgcg atctcactaa gacaaaagga agtggaaaca cagtgtccat taagagtctg      180

aaattctgcc attctcagtt atccaacaac agtgtctctt tttttctata caacttggac      240

cattctcatg ccaactatta cttctgcaac ctatcaattt ttgatcctcc tccttctaaa      300

gtaactctta caggaggata tttgcatatt tatgaatcac aactt                      345


<210>  27
<211>  300
<212>  PRT
<213>  homo sapiens

<400>  27

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly 
    290                 295                 300 


<210>  28
<211>  124
<212>  PRT
<213>  mus musculus

<400>  28

Glu Ile Asn Gly Ser Ala Asp His Arg Met Phe Ser Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Ser Cys Lys Tyr Pro Glu Thr Val Gln Gln Leu Lys 
            20                  25                  30          


Met Arg Leu Phe Arg Glu Arg Glu Val Leu Cys Glu Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Ala Val Ser Ile Lys Asn Pro Met Leu Cys Leu 
    50                  55                  60                  


Tyr His Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Asn Asn Pro Asp 
65                  70                  75                  80  


Ser Ser Gln Gly Ser Tyr Tyr Phe Cys Ser Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Gln Glu Arg Asn Leu Ser Gly Gly Tyr Leu His Ile Tyr 
            100                 105                 110         


Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu 
        115                 120                 


<210>  29
<211>  199
<212>  PRT
<213>  homo sapiens

<400>  29

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  30
<211>  681
<212>  DNA
<213>  homo sapiens

<400>  30
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ccccgggtaa a                                                681


<210>  31
<211>  666
<212>  DNA
<213>  mus musculus

<400>  31
ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat cttcccccca       60

aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt tgtggtagac      120

atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt ggaggtgcac      180

acagctcaga cgaaaccccg ggaggagcag atcaacagca ctttccgttc agtcagtgaa      240

cttcccatca tgcaccagga ctggctcaat ggcaaggagt tcaaatgcag ggtcaacagt      300

gcagctttcc ctgcccccat cgagaaaacc atctccaaaa ccaaaggcag accgaaggct      360

ccacaggtgt acaccattcc acctcccaag gagcagatgg ccaaggataa agtcagtctg      420

acctgcatga taacaaactt cttccctgaa gacattactg tggagtggca gtggaatggg      480

cagccagcgg agaactacaa gaacactcag cccatcatgg acacagatgg ctcttacttc      540

gtctacagca agctcaatgt gcagaagagc aactgggagg caggaaatac tttcacctgc      600

tctgtgttac atgagggcct gcacaaccac catactgaga agagcctctc ccactctcct      660

ggtaaa                                                                 666


