                         SEQUENCE LISTING

<110>  ISIS INNOVATION LIMITED
 
<120>  METHOD

<130>  N405396GB

<140>  tbc
<141>  2015-05-20

<150>  GB 1508841.2
<151>  2015-05-22

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  2
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  3
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His 
1               5                   10                  15      


Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser 
            20                  25                  30          


Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr 
        35                  40                  45              


Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp 
    50                  55                  60                  


Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn 
65                  70                  75                  80  


Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val 
                85                  90                  95      


Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg 
            100                 105                 110         


Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr Cys 
        115                 120                 125             


Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr 
    130                 135                 140                 


Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe 
145                 150                 155                 160 


His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln 
                165                 170                 175     


Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr 
            180                 185                 190         


Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp 
        195                 200                 205             


Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro Asp 
    210                 215                 220                 


Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly 
225                 230                 235                 240 


Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr Lys 
                245                 250                 255     


Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr Phe 
            260                 265                 270         


Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe Asp 
        275                 280                 285             


Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln Ile 
    290                 295                 300                 


Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His Ser 
305                 310                 315                 320 


Leu Ser Glu Ile Thr Tyr Leu Gly Gln Pro Asp Ile Ser Ile Leu Gln 
                325                 330                 335     


Pro Ser Asn Val Pro Pro Pro Gln Ile Leu Ser Pro Leu Ser Tyr Ala 
            340                 345                 350         


Pro Asn Ala Ala Pro Glu Val Gly Pro Pro Ser Tyr Ala Pro Gln Val 
        355                 360                 365             


Thr Pro Glu Ala Gln Phe Pro Phe Tyr Ala Pro Gln Ala Ile Ser Lys 
    370                 375                 380                 


Val Gln Pro Ser Ser Tyr Ala Pro Gln Ala Thr Pro Asp Ser Trp Pro 
385                 390                 395                 400 


Pro Ser Tyr Gly Val Cys Met Glu Gly Ser Gly Lys Asp Ser Pro Thr 
                405                 410                 415     


Gly Thr Leu Ser Ser Pro Lys His Leu Arg Pro Lys Gly Gln Leu Gln 
            420                 425                 430         


Lys Glu Pro Pro Ala Gly Ser Cys Met Leu Gly Gly Leu Ser Leu Gln 
        435                 440                 445             


Glu Val Thr Ser Leu Ala Met Glu Glu Ser Gln Glu Ala Lys Ser Leu 
    450                 455                 460                 


His Gln Pro Leu Gly Ile Cys Thr Asp Arg Thr Ser Asp Pro Asn Val 
465                 470                 475                 480 


Leu His Ser Gly Glu Glu Gly Thr Pro Gln Tyr Leu Lys Gly Gln Leu 
                485                 490                 495     


Pro Leu Leu Ser Ser Val Gln Ile Glu Gly His Pro Met Ser Leu Pro 
            500                 505                 510         


Leu Gln Pro Pro Ser Arg Pro Cys Ser Pro Ser Asp Gln Gly Pro Ser 
        515                 520                 525             


Pro Trp Gly Leu Leu Glu Ser Leu Val Cys Pro Lys Asp Glu Ala Lys 
    530                 535                 540                 


Ser Pro Ala Pro Glu Thr Ser Asp Leu Glu Gln Pro Thr Glu Leu Asp 
545                 550                 555                 560 


Ser Leu Phe Arg Gly Leu Ala Leu Thr Val Gln Trp Glu Ser 
                565                 570                 


<210>  4
<211>  2988
<212>  DNA
<213>  Homo sapiens

<400>  4
agatcccgcc cagaacctgg aattccagag cacacagggc caggacacct ttgtacccct       60

gctccccacc ggcacaggtc ccacccaccc ccttctcccc gccccatgcc cgggtggagc      120

cagctgccag ggcgccaaga ctcccagccc tctctctgtg cacggcagag tagaggccaa      180

gggagggctc tgtgccagcc ccgatgagga cgctgctgac catcttgact gtgggatccc      240

tggctgctca cgcccctgag gacccctcgg atctgctcca gcacgtgaaa ttccagtcca      300

gcaactttga aaacatcctg acgtgggaca gcgggccgga gggcacccca gacacggtct      360

acagcatcga gtataagacg tacggagaga gggactgggt ggcaaagaag ggctgtcagc      420

ggatcacccg gaagtcctgc aacctgacgg tggagacggg caacctcacg gagctctact      480

atgccagggt caccgctgtc agtgcgggag gccggtcagc caccaagatg actgacaggt      540

tcagctctct gcagcacact accctcaagc cacctgatgt gacctgtatc tccaaagtga      600

gatcgattca gatgattgtt catcctaccc ccacgccaat ccgtgcaggc gatggccacc      660

ggctaaccct ggaagacatc ttccatgacc tgttctacca cttagagctc caggtcaacc      720

gcacctacca aatgcacctt ggagggaagc agagagaata tgagttcttc ggcctgaccc      780

ctgacacaga gttccttggc accatcatga tttgcgttcc cacctgggcc aaggagagtg      840

ccccctacat gtgccgagtg aagacactgc cagaccggac atggacctac tccttctccg      900

gagccttcct gttctccatg ggcttcctcg tcgcagtact ctgctacctg agctacagat      960

atgtcaccaa gccgcctgca cctcccaact ccctgaacgt ccagcgagtc ctgactttcc     1020

agccgctgcg cttcatccag gagcacgtcc tgatccctgt ctttgacctc agcggcccca     1080

gcagtctggc ccagcctgtc cagtactccc agatcagggt gtctggaccc agggagcccg     1140

caggagctcc acagcggcat agcctgtccg agatcaccta cttagggcag ccagacatct     1200

ccatcctcca gccctccaac gtgccacctc cccagatcct ctccccactg tcctatgccc     1260

caaacgctgc ccctgaggtc gggcccccat cctatgcacc tcaggtgacc cccgaagctc     1320

aattcccatt ctacgcccca caggccatct ctaaggtcca gccttcctcc tatgcccctc     1380

aagccactcc ggacagctgg cctccctcct atggggtatg catggaaggt tctggcaaag     1440

actcccccac tgggacactt tctagtccta aacaccttag gcctaaaggt cagcttcaga     1500

aagagccacc agctggaagc tgcatgttag gtggcctttc tctgcaggag gtgacctcct     1560

tggctatgga ggaatcccaa gaagcaaaat cattgcacca gcccctgggg atttgcacag     1620

acagaacatc tgacccaaat gtgctacaca gtggggagga agggacacca cagtacctaa     1680

agggccagct ccccctcctc tcctcagtcc agatcgaggg ccaccccatg tccctccctt     1740

tgcaacctcc ttcccgtcca tgttccccct cggaccaagg tccaagtccc tggggcctgc     1800

tggagtccct tgtgtgtccc aaggatgaag ccaagagccc agcccctgag acctcagacc     1860

tggagcagcc cacagaactg gattctcttt tcagaggcct ggccctgact gtgcagtggg     1920

agtcctgagg ggaatgggaa aggcttggtg cttcctccct gtccctaccc agtgtcacat     1980

ccttggctgt caatcccatg cctgcccacg ccacacactc tgcgatctgg cctcagacgg     2040

gtgcccttga gagaagcaga gggagtggca tgcagggccc ctgccatggg tgcgctcctc     2100

accggagcaa agcagcatga taaggactgc agcgggggag ctctggggag cagcttgtgt     2160

agacaagcgc gtgctcgctg agccctgcaa ggcagaaatg acagtgcaag gaggaaatgc     2220

agggaaactc ccgaggtcca gagccccacc tcctaacacc atggattcaa agtgctcagg     2280

gaatttgcct ctccttgccc cattcctggc cagtttcaca atctagctcg acagagcatg     2340

aggcccctgc ctcttctgtc attgttcaaa ggtgggaaga gagcctggaa aagaaccagg     2400

cctggaaaag aaccagaagg aggctgggca gaaccagaac aacctgcact tctgccaagg     2460

ccagggccag caggacggca ggactctagg gaggggtgtg gcctgcagct cattcccagc     2520

cagggcaact gcctgacgtt gcacgatttc agcttcattc ctctgataga acaaagcgaa     2580

atgcaggtcc accagggagg gagacacaca agccttttct gcaggcagga gtttcagacc     2640

ctatcctgag aatggggttt gaaaggaagg tgagggctgt ggcccctgga cgggtacaat     2700

aacacactgt actgatgtca caactttgca agctctgcct tgggttcagc ccatctgggc     2760

tcaaattcca gcctcaccac tcacaagctg tgtgacttca aacaaatgaa atcagtgccc     2820

agaacctcgg tttcctcatc tgtaatgtgg ggatcataac acctacctca tggagttgtg     2880

gtgaagatga aatgaagtca tgtctttaaa gtgcttaata gtgcctggta catgggcagt     2940

gcccaataaa cggtagctat ttaaaaaaaa aaaaaaaaaa aaaaaaaa                  2988


<210>  5
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  6
<211>  1147
<212>  DNA
<213>  Homo sapiens

<400>  6
cgaccaggtt ctccttcccc agtcaccagt tgctcgagtt agaattgtct gcaatggccg       60

ccctgcagaa atctgtgagc tctttcctta tggggaccct ggccaccagc tgcctccttc      120

tcttggccct cttggtacag ggaggagcag ctgcgcccat cagctcccac tgcaggcttg      180

acaagtccaa cttccagcag ccctatatca ccaaccgcac cttcatgctg gctaaggagg      240

ctagcttggc tgataacaac acagacgttc gtctcattgg ggagaaactg ttccacggag      300

tcagtatgag tgagcgctgc tatctgatga agcaggtgct gaacttcacc cttgaagaag      360

tgctgttccc tcaatctgat aggttccagc cttatatgca ggaggtggtg cccttcctgg      420

ccaggctcag caacaggcta agcacatgtc atattgaagg tgatgacctg catatccaga      480

ggaatgtgca aaagctgaag gacacagtga aaaagcttgg agagagtgga gagatcaaag      540

caattggaga actggatttg ctgtttatgt ctctgagaaa tgcctgcatt tgaccagagc      600

aaagctgaaa aatgaataac taaccccctt tccctgctag aaataacaat tagatgcccc      660

aaagcgattt tttttaacca aaaggaagat gggaagccaa actccatcat gatgggtgga      720

ttccaaatga acccctgcgt tagttacaaa ggaaaccaat gccacttttg tttataagac      780

cagaaggtag actttctaag catagatatt tattgataac atttcattgt aactggtgtt      840

ctatacacag aaaacaattt attttttaaa taattgtctt tttccataaa aaagattact      900

ttccattcct ttaggggaaa aaacccctaa atagcttcat gtttccataa tcagtacttt      960

atatttataa atgtatttat tattattata agactgcatt ttatttatat cattttatta     1020

atatggattt atttatagaa acatcattcg atattgctac ttgagtgtaa ggctaatatt     1080

gatatttatg acaataatta tagagctata acatgtttat ttgacctcaa taaacacttg     1140

gatatcc                                                               1147


<210>  7
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  8
<211>  1252
<212>  DNA
<213>  Homo sapiens

<400>  8
ctttgaattc ctagctcctg tggtctccag atttcaggcc taagatgaaa gcctctagtc       60

ttgccttcag ccttctctct gctgcgtttt atctcctatg gactccttcc actggactga      120

agacactcaa tttgggaagc tgtgtgatcg ccacaaacct tcaggaaata cgaaatggat      180

tttctgagat acggggcagt gtgcaagcca aagatggaaa cattgacatc agaatcttaa      240

ggaggactga gtctttgcaa gacacaaagc ctgcgaatcg atgctgcctc ctgcgccatt      300

tgctaagact ctatctggac agggtattta aaaactacca gacccctgac cattatactc      360

tccggaagat cagcagcctc gccaattcct ttcttaccat caagaaggac ctccggctct      420

gtcatgccca catgacatgc cattgtgggg aggaagcaat gaagaaatac agccagattc      480

tgagtcactt tgaaaagctg gaacctcagg cagcagttgt gaaggctttg ggggaactag      540

acattcttct gcaatggatg gaggagacag aataggagga aagtgatgct gctgctaaga      600

atattcgagg tcaagagctc cagtcttcaa tacctgcaga ggaggcatga ccccaaacca      660

ccatctcttt actgtactag tcttgtgctg gtcacagtgt atcttattta tgcattactt      720

gcttccttgc atgattgtct ttatgcatcc ccaatcttaa ttgagaccat acttgtataa      780

gatttttgta atatctttct gctattggat atatttatta gttaatatat ttatttattt      840

tttgctattt aatgtattta tttttttact tggacatgaa actttaaaaa aattcacaga      900

ttatatttat aacctgacta gagcaggtga tgtattttta tacagtaaaa aaaaaaaacc      960

ttgtaaattc tagaagagtg gctagggggg ttattcattt gtattcaact aaggacatat     1020

ttactcatgc tgatgctctg tgagatattt gaaattgaac caatgactac ttaggatggg     1080

ttgtggaata agttttgatg tggaattgca catctacctt acaattactg accatcccca     1140

gtagactccc cagtcccata attgtgtatc ttccagccag gaatcctaca cggccagcat     1200

gtatttctac aaataaagtt ttctttgcat aacaaaaaaa aaaaaaaaaa aa             1252


<210>  9
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asn Phe Gln Gln Arg Leu Gln Ser Leu Trp Thr Leu Ala Ser Arg 
1               5                   10                  15      


Pro Phe Cys Pro Pro Leu Leu Ala Thr Ala Ser Gln Met Gln Met Val 
            20                  25                  30          


Val Leu Pro Cys Leu Gly Phe Thr Leu Leu Leu Trp Ser Gln Val Ser 
        35                  40                  45              


Gly Ala Gln Gly Gln Glu Phe His Phe Gly Pro Cys Gln Val Lys Gly 
    50                  55                  60                  


Val Val Pro Gln Lys Leu Trp Glu Ala Phe Trp Ala Val Lys Asp Thr 
65                  70                  75                  80  


Met Gln Ala Gln Asp Asn Ile Thr Ser Ala Arg Leu Leu Gln Gln Glu 
                85                  90                  95      


Val Leu Gln Asn Val Ser Asp Ala Glu Ser Cys Tyr Leu Val His Thr 
            100                 105                 110         


Leu Leu Glu Phe Tyr Leu Lys Thr Val Phe Lys Asn Tyr His Asn Arg 
        115                 120                 125             


Thr Val Glu Val Arg Thr Leu Lys Ser Phe Ser Thr Leu Ala Asn Asn 
    130                 135                 140                 


Phe Val Leu Ile Val Ser Gln Leu Gln Pro Ser Gln Glu Asn Glu Met 
145                 150                 155                 160 


Phe Ser Ile Arg Asp Ser Ala His Arg Arg Phe Leu Leu Phe Arg Arg 
                165                 170                 175     


Ala Phe Lys Gln Leu Asp Val Glu Ala Ala Leu Thr Lys Ala Leu Gly 
            180                 185                 190         


Glu Val Asp Ile Leu Leu Thr Trp Met Gln Lys Phe Tyr Lys Leu 
        195                 200                 205         


<210>  10
<211>  1979
<212>  DNA
<213>  Homo sapiens

<400>  10
gcttgcctgc aaacctttac ttctgaaatg acttccacgg ctgggacggg aaccttccac       60

ccacagctat gcctctgatt ggtgaatggt gaaggtgcct gtctaacttt tctgtaaaaa      120

gaaccagctg cctccaggca gccagccctc aagcatcact tacaggacca gagggacaag      180

acatgactgt gatgaggagc tgctttcgcc aatttaacac caagaagaat tgaggctgct      240

tgggaggaag gccaggagga acacgagact gagagatgaa ttttcaacag aggctgcaaa      300

gcctgtggac tttagccagc agacccttct gccctccttt gctggcgaca gcctctcaaa      360

tgcagatggt tgtgctccct tgcctgggtt ttaccctgct tctctggagc caggtatcag      420

gggcccaggg ccaagaattc cactttgggc cctgccaagt gaagggggtt gttccccaga      480

aactgtggga agccttctgg gctgtgaaag acactatgca agctcaggat aacatcacga      540

gtgcccggct gctgcagcag gaggttctgc agaacgtctc ggatgctgag agctgttacc      600

ttgtccacac cctgctggag ttctacttga aaactgtttt caaaaactac cacaatagaa      660

cagttgaagt caggactctg aagtcattct ctactctggc caacaacttt gttctcatcg      720

tgtcacaact gcaacccagt caagaaaatg agatgttttc catcagagac agtgcacaca      780

ggcggtttct gctattccgg agagcattca aacagttgga cgtagaagca gctctgacca      840

aagcccttgg ggaagtggac attcttctga cctggatgca gaaattctac aagctctgaa      900

tgtctagacc aggacctccc tccccctggc actggtttgt tccctgtgtc atttcaaaca      960

gtctcccttc ctatgctgtt cactggacac ttcacgccct tggccatggg tcccattctt     1020

ggcccaggat tattgtcaaa gaagtcattc tttaagcagc gccagtgaca gtcagggaag     1080

gtgcctctgg atgctgtgaa gagtctacag agaagattct tgtatttatt acaactctat     1140

ttaattaatg tcagtatttc aactgaagtt ctatttattt gtgagactgt aagttacatg     1200

aaggcagcag aatattgtgc cccatgcttc tttacccctc acaatccttg ccacagtgtg     1260

gggcagtgga tgggtgctta gtaagtactt aataaactgt ggtgcttttt ttggcctgtc     1320

tttggattgt taaaaaacag agagggatgc ttggatgtaa aactgaactt cagagcatga     1380

aaatcacact gtcttctgat atctgcaggg acagagcatt ggggtggggg taaggtgcat     1440

ctgtttgaaa agtaaacgat aaaatgtgga ttaaagtgcc cagcacaaag cagatcctca     1500

ataaacattt catttcccac ccacactcgc cagctcaccc catcatccct ttcccttggt     1560

gccctccttt tttttttatc ctagtcattc ttccctaatc ttccacttga gtgtcaagct     1620

gaccttgctg atggtgacat tgcacctgga tgtactatcc aatctgtgat gacattccct     1680

gctaataaaa gacaacataa ctcaagtctg gcagactttc ttctctattt ctggatgaat     1740

gcccagtgag actgtgttgt acagctagaa aaggccttct tcccaatagc aaggctgtgc     1800

atctagcctc aagctctggc tgaactttgt ggtcgacatc aatctaaaga tacagtgtct     1860

gactataacc ttgttccaaa aacctaggca aagagtatat gtaggaggtg ggatatcact     1920

tccatgacat aagtgctatt gcagagccgt ggccacccag gaactcctga ctgctttcc      1979


<210>  11
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1               5                   10                  15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
            20                  25                  30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
        35                  40                  45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Ile Met Phe Ser Cys Ser Met Lys Ser Ser His Gln Lys Pro Ser 
65                  70                  75                  80  


Gly Cys Trp Gln His Ile Ser Cys Asn Phe Pro Gly Cys Arg Thr Leu 
                85                  90                  95      


Ala Lys Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
            100                 105                 110         


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
        115                 120                 125             


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
    130                 135                 140                 


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
145                 150                 155                 160 


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
                165                 170                 175     


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
            180                 185                 190         


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
        195                 200                 205             


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
    210                 215                 220                 


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
225                 230                 235                 240 


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
                245                 250                 255     


Glu Arg Cys Val Glu Ile Pro 
            260             


