               SEQUENCE LISTING

<110> Bayer Pharma Aktiengesellschaft

<120> Method for stratification of melanoma patients by determination of oxygen consumption, PPARGC1A, PPARGC1B and MITF levels

<130> BHC143087FC

<160> 6

<170> BiSSAP 1.3

<210> 1
<211> 6318
<212> DNA
<213> PPARGC1A melanoma cell line

<220> 
<223> NM_013261

<400> 1
tagtaagaca ggtgccttca gttcactctc agtaaggggc tggttgcctg catgagtgtg       60

tgctctgtgt cactgtggat tggagttgaa aaagcttgac tggcgtcatt caggagctgg      120

atggcgtggg acatgtgcaa ccaggactct gagtctgtat ggagtgacat cgagtgtgct      180

gctctggttg gtgaagacca gcctctttgc ccagatcttc ctgaacttga tctttctgaa      240

ctagatgtga acgacttgga tacagacagc tttctgggtg gactcaagtg gtgcagtgac      300

caatcagaaa taatatccaa tcagtacaac aatgagcctt caaacatatt tgagaagata      360

gatgaagaga atgaggcaaa cttgctagca gtcctcacag agacactaga cagtctccct      420

gtggatgaag acggattgcc ctcatttgat gcgctgacag atggagacgt gaccactgac      480

aatgaggcta gtccttcctc catgcctgac ggcacccctc caccccagga ggcagaagag      540

ccgtctctac ttaagaagct cttactggca ccagccaaca ctcagctaag ttataatgaa      600

tgcagtggtc tcagtaccca gaaccatgca aatcacaatc acaggatcag aacaaaccct      660

gcaattgtta agactgagaa ttcatggagc aataaagcga agagtatttg tcaacagcaa      720

aagccacaaa gacgtccctg ctcggagctt ctcaaatatc tgaccacaaa cgatgaccct      780

cctcacacca aacccacaga gaacagaaac agcagcagag acaaatgcac ctccaaaaag      840

aagtcccaca cacagtcgca gtcacaacac ttacaagcca aaccaacaac tttatctctt      900

cctctgaccc cagagtcacc aaatgacccc aagggttccc catttgagaa caagactatt      960

gaacgcacct taagtgtgga actctctgga actgcaggcc taactccacc caccactcct     1020

cctcataaag ccaaccaaga taaccctttt agggcttctc caaagctgaa gtcctcttgc     1080

aagactgtgg tgccaccacc atcaaagaag cccaggtaca gtgagtcttc tggtacacaa     1140

ggcaataact ccaccaagaa agggccggag caatccgagt tgtatgcaca actcagcaag     1200

tcctcagtcc tcactggtgg acacgaggaa aggaagacca agcggcccag tctgcggctg     1260

tttggtgacc atgactattg ccagtcaatt aattccaaaa cagaaatact cattaatata     1320

tcacaggagc tccaagactc tagacaacta gaaaataaag atgtctcctc tgattggcag     1380

gggcagattt gttcttccac agattcagac cagtgctacc tgagagagac tttggaggca     1440

agcaagcagg tctctccttg cagcacaaga aaacagctcc aagaccagga aatccgagcc     1500

gagctgaaca agcacttcgg tcatcccagt caagctgttt ttgacgacga agcagacaag     1560

accggtgaac tgagggacag tgatttcagt aatgaacaat tctccaaact acctatgttt     1620

ataaattcag gactagccat ggatggcctg tttgatgaca gcgaagatga aagtgataaa     1680

ctgagctacc cttgggatgg cacgcaatcc tattcattgt tcaatgtgtc tccttcttgt     1740

tcttctttta actctccatg tagagattct gtgtcaccac ccaaatcctt attttctcaa     1800

agaccccaaa ggatgcgctc tcgttcaagg tccttttctc gacacaggtc gtgttcccga     1860

tcaccatatt ccaggtcaag atcaaggtct ccaggcagta gatcctcttc aagatcctgc     1920

tattactatg agtcaagcca ctacagacac cgcacgcacc gaaattctcc cttgtatgtg     1980

agatcacgtt caagatcgcc ctacagccgt cggcccaggt atgacagcta cgaggaatat     2040

cagcacgaga ggctgaagag ggaagaatat cgcagagagt atgagaagcg agagtctgag     2100

agggccaagc aaagggagag gcagaggcag aaggcaattg aagagcgccg tgtgatttat     2160

gtcggtaaaa tcagacctga cacaacacgg acagaactga gggaccgttt tgaagttttt     2220

ggtgaaattg aggagtgcac agtaaatctg cgggatgatg gagacagcta tggtttcatt     2280

acctaccgtt atacctgtga tgcttttgct gctcttgaaa atggatacac tttgcgcagg     2340

tcaaacgaaa ctgactttga gctgtacttt tgtggacgca agcaattttt caagtctaac     2400

tatgcagacc tagattcaaa ctcagatgac tttgaccctg cttccaccaa gagcaagtat     2460

gactctctgg attttgatag tttactgaaa gaagctcaga gaagcttgcg caggtaacat     2520

gttccctagc tgaggatgac agagggatgg cgaatacctc atgggacagc gcgtccttcc     2580

ctaaagacta ttgcaagtca tacttaggaa tttctcctac tttacactct ctgtacaaaa     2640

acaaaacaaa acaacaacaa tacaacaaga acaacaacaa caataacaac aatggtttac     2700

atgaacacag ctgctgaaga ggcaagagac agaatgatat ccagtaagca catgtttatt     2760

catgggtgtc agctttgctt ttcctggagt ctcttggtga tggagtgtgc gtgtgtgcat     2820

gtatgtgtgt gtgtatgtat gtgtgtggtg tgtgtgcttg gtttagggga agtatgtgtg     2880

ggtacatgtg aggactgggg gcacctgacc agaatgcgca agggcaaacc atttcaaatg     2940

gcagcagttc catgaagaca cgcttaaaac ctagaacttc aaaatgttcg tattctattc     3000

aaaaggaaat atatatatat atatatatat atatatatat atatataaat taaaaaggaa     3060

agaaaactaa caaccaacca accaaccaac caaccacaaa ccaccctaaa atgacagccg     3120

ctgatgtctg ggcatcagcc tttgtactct gtttttttaa gaaagtgcag aatcaacttg     3180

aagcaagctt tctctcataa cgtaatgatt atatgacaat cctgaagaaa ccacaggttc     3240

catagaacta atatcctgtc tctctctctc tctctctctc tctctttttt ttttcttttt     3300

ccttttgcca tggaatctgg gtgggagagg atactgcggg caccagaatg ctaaagtttc     3360

ctaacatttt gaagtttctg tagttcatcc ttaatcctga cacccatgta aatgtccaaa     3420

atgttgatct tccactgcaa atttcaaaag ccttgtcaat ggtcaagcgt gcagcttgtt     3480

cagcggttct ttctgaggag cggacaccgg gttacattac taatgagagt tgggtagaac     3540

tctctgagat gtgttcagat agtgtaattg ctacattctc tgatgtagtt aagtatttac     3600

agatgttaaa tggagtattt ttattttatg tatatactat acaacaatgt tcttttttgt     3660

tacagctatg cactgtaaat gcagccttct tttcaaaact gctaaatttt tcttaatcaa     3720

gaatattcaa atgtaattat gaggtgaaac aattattgta cactaacata tttagaagct     3780

gaacttactg cttatatata tttgattgta aaaacaaaaa gacagtgtgt gtgtctgttg     3840

agtgcaacaa gagcaaaatg atgctttccg cacatccatc ccttaggtga gcttcaatct     3900

aagcatcttg tcaagaaata tcctagtccc ctaaaggtat taaccacttc tgcgatattt     3960

ttccacattt tcttgtcgct tgtttttctt tgaagtttta tacactggat ttgttagggg     4020

aatgaaattt tctcatctaa aatttttcta gaagatatca tgattttatg taaagtctct     4080

caatgggtaa ccattaagaa atgtttttat tttctctatc aacagtagtt ttgaaactag     4140

aagtcaaaaa tctttttaaa atgctgtttt gttttaattt ttgtgatttt aatttgatac     4200

aaaatgctga ggtaataatt atagtatgat ttttacaata attaatgtgt gtctgaagac     4260

tatctttgaa gccagtattt ctttcccttg gcagagtatg acgatggtat ttatctgtat     4320

tttttacagt tatgcatcct gtataaatac tgatatttca ttcctttgtt tactaaagag     4380

acatatttat cagttgcaga tagcctattt attataaatt atgagatgat gaaaataata     4440

aagccagtgg aaattttcta cctaggatgc atgacaattg tcaggttgga gtgtaagtgc     4500

ttcatttggg aaattcagct tttgcagaag cagtgtttct acttgcacta gcatggcctc     4560

tgacgtgacc atggtgttgt tcttgatgac attgcttctg ctaaatttaa taaaaacttc     4620

agaaaaacct ccattttgat catcaggatt tcatctgagt gtggagtccc tggaatggaa     4680

ttcagtaaca tttggagtgt gtattcaagt ttctaaattg agattcgatt actgtttggc     4740

tgacatgact tttctggaag acatgataca cctactactc aattgttctt ttcctttctc     4800

tcgcccaaca cgatcttgta agatggattt cacccccagg ccaatgcagc taattttgat     4860

agctgcattc atttatcacc agcatattgt gttctgagtg aatccactgt ttgtcctgtc     4920

ggatgcttgc ttgatttttt ggcttcttat ttctaagtag atagaaagca ataaaaatac     4980

tatgaaatga aagaacttgt tcacaggttc tgcgttacaa cagtaacaca tctttaatcc     5040

gcctaattct tgttgttctg taggttaaat gcaggtattt taactgtgtg aacgccaaac     5100

taaagtttac agtctttctt tctgaatttt gagtatcttc tgttgtagaa taataataaa     5160

aagactatta agagcaataa attattttta agaaatcgag atttagtaaa tcctattatg     5220

tgttcaagga ccacatgtgt tctctatttt gcctttaaat ttttgtgaac caattttaaa     5280

tacattctcc tttttgccct ggattgttga catgagtgga atacttggtt tcttttctta     5340

cttatcaaaa gacagcacta cagatatcat attgaggatt aatttatccc ccctaccccc     5400

agcctgacaa atattgttac catgaagata gttttcctca atggacttca aattgcatct     5460

agaattagtg gagcttttgt atcttctgca gacactgtgg gtagcccatc aaaatgtaag     5520

ctgtgctcct ctcattttta tttttatttt tttgggagag aatatttcaa atgaacacgt     5580

gcaccccatc atcactggag gcaaatttca gcatagatct gtaggatttt tagaagaccg     5640

tgggccattg ccttcatgcc gtggtaagta ccacatctac aattttggta accgaactgg     5700

tgctttagta atgtggattt ttttcttttt taaaagagat gtagcagaat aattcttcca     5760

gtgcaacaaa atcaattttt tgctaaacga ctccgagaac aacagttggg ctgtcaacat     5820

tcaaagcagc agagagggaa ctttgcacta ttggggtatg atgtttgggt cagttgataa     5880

aaggaaacct tttcatgcct ttagatgtga gcttccagta ggtaatgatt atgtgtcctt     5940

tcttgatggc tgtaatgaga acttcaatca ctgtagtcta agacctgatc tatagatgac     6000

ctagaatagc catgtactat aatgtgatga ttctaaattt gtacctatgt gacagacatt     6060

ttcaataatg tgaactgctg atttgatgga gctactttaa gatttgtagg tgaaagtgta     6120

atactgttgg ttgaactatg ctgaagaggg aaagtgagcg attagttgag cccttgccgg     6180

gccttttttc cacctgccaa ttctacatgt attgttgtgg ttttattcat tgtatgaaaa     6240

ttcctgtgat tttttttaaa tgtgcagtac acatcagcct cactgagcta ataaagggaa     6300

acgaatgttt caaatcta                                                   6318


<210> 2
<211> 10642
<212> DNA
<213> PPARGC1B melanoma cell line

<220> 
<223> NM_133263

<400> 2
ctcctccctc ctcccttgct cgctcgctgg ctccctcccc ccgggccggc tcggcgttga       60

ctccgccgca cgctgcagcc gcggctggaa gatggcgggg aacgactgcg gcgcgctgct      120

ggacgaagag ctctcctcct tcttcctcaa ctatctcgct gacacgcagg gtggagggtc      180

cggggaggag caactctatg ctgactttcc agaacttgac ctctcccagc tggatgccag      240

cgactttgac tcggccacct gctttgggga gctgcagtgg tgcccagaga actcagagac      300

tgaacccaac cagtacagcc ccgatgactc cgagctcttc cagattgaca gtgagaatga      360

ggccctcctg gcagagctca ccaagaccct ggatgacatc cctgaagatg acgtgggtct      420

ggctgccttc ccagccctgg atggtggaga cgctctatca tgcacctcag cttcgcctgc      480

cccctcatct gcacccccca gccctgcccc ggagaagccc tcggccccag cccctgaggt      540

ggacgagctc tcactgctgc agaagctcct cctggccaca tcctacccaa catcaagctc      600

tgacacccag aaggaaggga ccgcctggcg ccaggcaggc ctcagatcta aaagtcaacg      660

gccttgtgtt aaggcggaca gcacccaaga caagaaggct cccatgatgc agtctcagag      720

ccgaagttgt acagaactac ataagcacct cacctcggca cagtgctgcc tgcaggatcg      780

gggtctgcag ccaccatgcc tccagagtcc ccggctccct gccaaggagg acaaggagcc      840

gggtgaggac tgcccgagcc cccagccagc tccagcctct ccccgggact ccctagctct      900

gggcagggca gaccccggtg ccccggtttc ccaggaagac atgcaggcga tggtgcaact      960

catacgctac atgcacacct actgcctccc ccagaggaag ctgcccccac agacccctga     1020

gccactcccc aaggcctgca gcaacccctc ccagcaggtc agatcccggc cctggtcccg     1080

gcaccactcc aaagcctcct gggctgagtt ctccattctg agggaacttc tggctcaaga     1140

cgtgctctgt gatgtcagca aaccctaccg tctggccacg cctgtttatg cctccctcac     1200

acctcggtca aggcccaggc cccccaaaga cagtcaggcc tcccctggtc gcccgtcctc     1260

ggtggaggag gtaaggatcg cagcttcacc caagagcacc gggcccagac caagcctgcg     1320

cccactgcgg ctggaggtga aaagggaggt ccgccggcct gccagactgc agcagcagga     1380

ggaggaagac gaggaagaag aggaggagga agaggaagaa gaaaaagagg aggaggagga     1440

gtggggcagg aaaaggccag gccgaggcct gccatggacg aagctgggga ggaagctgga     1500

gagctctgtg tgccccgtgc ggcgttctcg gagactgaac cctgagctgg gcccctggct     1560

gacatttgca gatgagccgc tggtcccctc ggagccccaa ggtgctctgc cctcactgtg     1620

cctggctccc aaggcctacg acgtagagcg ggagctgggc agccccacgg acgaggacag     1680

tggccaagac cagcagctcc tacggggacc ccagatccct gccctggaga gcccctgtga     1740

gagtgggtgt ggggacatgg atgaggaccc cagctgcccg cagctccctc ccagagactc     1800

tcccaggtgc ctcatgctgg ccttgtcaca aagcgaccca acttttggca agaagagctt     1860

tgagcagacc ttgacagtgg agctctgtgg cacagcagga ctcaccccac ccaccacacc     1920

accgtacaag cccacagagg aggatccctt caaaccagac atcaagcata gtctaggcaa     1980

agaaatagct ctcagcctcc cctcccctga gggcctctca ctcaaggcca ccccaggggc     2040

tgcccacaag ctgccaaaga agcacccaga gcgaagtgag ctcctgtccc acctgcgaca     2100

tgccacagcc cagccagcct cccaggctgg ccagaagcgt cccttctcct gttcctttgg     2160

agaccatgac tactgccagg tgctccgacc agaaggcgtc ctgcaaagga aggtgctgag     2220

gtcctgggag ccgtctgggg ttcaccttga ggactggccc cagcagggtg ccccttgggc     2280

tgaggcacag gcccctggca gggaggaaga cagaagctgt gatgctggcg ccccacccaa     2340

ggacagcacg ctgctgagag accatgagat ccgtgccagc ctcaccaaac actttgggct     2400

gctggagacc gccctggagg aggaagacct ggcctcctgc aagagccctg agtatgacac     2460

tgtctttgaa gacagcagca gcagcagcgg cgagagcagc ttcctcccag aggaggaaga     2520

ggaagaaggg gaggaggagg aggaggacga tgaagaagag gactcagggg tcagccccac     2580

ttgctctgac cactgcccct accagagccc accaagcaag gccaaccggc agctctgttc     2640

ccgcagccgc tcaagctctg gctcttcacc ctgccactcc tggtcaccag ccactcgaag     2700

gaacttcaga tgtgagagca gagggccgtg ttcagacaga acgccaagca tccggcacgc     2760

caggaagcgg cgggaaaagg ccattgggga aggccgcgtg gtgtacattc aaaatctctc     2820

cagcgacatg agctcccgag agctgaagag gcgctttgaa gtgtttggtg agattgagga     2880

gtgcgaggtg ctgacaagaa ataggagagg cgagaagtac ggcttcatca cctaccggtg     2940

ttctgagcac gcggccctct ctttgacaaa gggcgctgcc ctgaggaagc gcaacgagcc     3000

ctccttccag ctgagctacg gagggctccg gcacttctgc tggcccagat acactgacta     3060

cgattccaat tcagaagagg cccttcctgc gtcagggaaa agcaagtatg aagccatgga     3120

ttttgacagc ttactgaaag aggcccagca gagcctgcat tgataacagc cttaaccctc     3180

gaggaatacc tcaatacctc agacaaggcc cttccaatat gtttacgttt tcaaagaaat     3240

caagtatatg aggagagcga gcgagcgtga gagaacaccc gtgagagaga cttgaaactg     3300

ctgtccttta aaaaaaaaaa aaatcaatgt ttacattgaa caaagctgct tctgtctgtg     3360

agtttccatg gtgttgacgt tccactgcca cattagtgtc ctcgcttcca acgggttgtc     3420

ccgggtgcac ctcgaagtgc cgggtccgtc acccatcgcc ccttccttcc cgactgactt     3480

cctctcgtag acttgcagct gtgttcacca taacatttct tgtctgtagt gtgtgatgat     3540

gaaattgtta cttgtgaata gaatcaggac tataaacttc atttttaatt gaaaaaaaaa     3600

gtatatcctt aaaataatgt atttatggct cagatgtact gtgcctggga ttattgtatt     3660

gcttccttga ttttttaact atgcactgtc atgaggtgtt tgccactgag ctgccctgct     3720

ccccttgcca gattgccctg gaggtgctgg gtggccgcta ggctggtctg caggaaagcg     3780

cggcctgccg tttccgggcc gtatctgcca agccctgcct tgtctcttac tgagcaagtt     3840

tggctcaaat tataggagcc cccatcttgt gcccagctca tgctccaagt gtgtgtctat     3900

ccatttgtac tcagactctt gagtaccttg taaggaaggc ggggcaagct gcatcattcc     3960

tgttttccag gggaggctgg cagctcctca agaggcgaaa tgactgtggg aggtccggtt     4020

accagtgagg aggcagagcg gtgacccaga ccaggccttc tggttcttgg tcccgtgctt     4080

ccgtagtagc tggggtaaag acaccgtttc agggactggt agaggtgagt tcggctaaat     4140

tgggcaccgg gctagaagcc taagggctca ttttaggggt tacattaggt gttgattcac     4200

cagcatcagg tgaattcaag ccctggcatg tgtcttggat gcaccatcag ctttgatcct     4260

gagtggtcct gcggtttgtc tgtgcctgtg gacacactgt cagaacttca gtgacacccc     4320

tggcagcggt acagacaggt ggtctgggag cagtcatctt ttttgggcca gccaccagcc     4380

catcctactc cctcaggtag tccttcgtct ttaccttgtc cttgtctgta aagttgtttt     4440

ggtggctggg gcaggggagc caggaggagg gagtgaaggt tgggaataga taggacaatc     4500

tcctagctct cctccaattg agaaaacact ccaattgggc tttgctttaa actttgtgtt     4560

cttaagtgat gtcaaagcca tttccagctt aatgttctgt gggtaccttg ggggccattc     4620

atgcagggag catggccagg cagggtatga gtacattgtt tctgatttct ttcatacatc     4680

agggttcctc gggaaatttt tgtatttttt ttttaagtcc tgctgcttta aaaatttgaa     4740

agtggctcat taaactaaac aggctaatgt aatttgttgc ttatgccaag cctagactgt     4800

tgagaattga cgtttttaaa gattatcaaa tacctcagta ggtaaaatga gcccatgatc     4860

ttccactgag tggtgagcat actcccagcc catggacaag gccggaagag acaggcttta     4920

gtaggggtag ggaatttgaa ctgttgtgtg tcacagcagt tgacctctct ggactccaat     4980

ttcctttcct gtgaaatgaa ctgattagac atgtttcaac attgttagct tctgctgagg     5040

cagtgtctag cccaagatgg caaatacata gctcatgtgc cactactccc acctccttga     5100

ccaatacaga cataactaat caatcacacc actcaggttc cctgagcctg gatgtgctat     5160

aagaatcctg aaatcagtgc tctggtaagt cattactaat tgattagagt tcaatctatt     5220

tgacatcttg ggctaatctt tggaaggttt ccaacaatca cacaaaacca tatgctggct     5280

gggtttcatg ctggcctatc cctgtctgtg atgttccgtt ccatgagaga aaactcccct     5340

aatgctattc catggcgtaa cactcccaat actattttga cgcccacgtc cccttgcaga     5400

gggtgcaggg ggcggtagac gaatgacaga caggaacata tttggggaag gcagggctta     5460

ggaagatgga ccaaaaaggg acttcccaca gcacagacct gatcattcgg atttcctctt     5520

tagctattca ctgcctagca catagtaggc acacaataaa tgattatgga atgggataaa     5580

atttagatct ttctgctgcc tccactaagt taagtcctga tttacatcaa ggagagaact     5640

gagataggaa agaacactag attccaagtc tggagagttg ggggagtcca gattctacca     5700

agaatttcct ttgtaacttt ggtaagtccc ttttactccc tggcaccccg gtgtgctgaa     5760

aggagttggt ccatatatga tctcttagcc cctcctattt gcttcttcct tgattgctct     5820

tggtcaaagg gtcagccttg ggctggtgat actttagagt aaagaaatgg agagttttag     5880

caaaggacca gtctgtccct ccctgctttg gggtcagcta aagctgtcct ttcatgtcag     5940

attaacctag gacacttgta gttagcttag acgttggccc ttgagcagag acctgagcgt     6000

ggcattggga catgacatac ctaaagtcag ggctagggga cgctgcctgc caagggcatc     6060

gagtagtctc tacttgctat cccgtacata aaatgctaca agttctaaaa tttaccgacc     6120

ctgcagacaa cctctatccc gaaggactca ttcggtgctg tgtattattt agggcaactc     6180

caaggtctat tcagaaaaac gagtgaacct tggtctcttt cccaccaaat tgaggagtaa     6240

cccagaggga gcagctgcca ttggcaacca tctcgttgta gctctgtcct agtgtttgct     6300

cttgatgatg tttacatgtg atcgccataa agcttgctgt agactgtgtc gatagccgcc     6360

cgcacagggc aggtcgtact gtccgtttct gtgccgtgct ggtgttttcc aaaaatgtct     6420

gatccaacca ctaagtggaa ttcttccatc tccttcctca gtctgtacaa ggctgaatca     6480

gaatccccat tctcgggggc tctggttacc gaaggaaaat gcatcaaaga gttaaagaat     6540

atgagtggat ggagtgcagc taaggccccc accccctgct ccgtcacaac ttgccccctc     6600

aaccaaaaag ctgctttgag tcaaaaagca cccataagat acctgcatct gccttgaaat     6660

cttgcagcat ggagtgtcat atgtactcag gagagaggca gggctttgcg ggcaggagaa     6720

ggaagggagg aatgctctga gctgcaaaga cccagtactc aagttctgac gtgggaggag     6780

atgcagtgag acgtctcttg ttgcctaaag cctgttcctg ttggttttct tagagtgatt     6840

tctcctagac atgtgcagta ggcccactgg ggctgctgtg cagtggtgag taaaagggca     6900

gggaaggcat ggacagcctg gtccttctgc atggacagct cagtccatgg cccatcccag     6960

gtatagagtt cagttaatcc catttgagcc tgcagcttaa gagatggctc atcctaactg     7020

tgaagcaaaa tcagccccag aggatgtatt gatctgactc actgatgtca aaattgcagt     7080

atttttttag catttgagat ttagcagctg ccttcagttt ggggttaccc acatcccagc     7140

atcagatatg attaaggaaa gaaattggat gtacaacagc aaagaaagtg aatgtcatgg     7200

tttccctggc caaagaagag ggaccctgtc atccttacca atggggaaga agaaaactag     7260

tgcatgtgca atatgtcaaa gttagtcccc tagtccctga ggggttttta cacacagatg     7320

ggctccaggt ctgctcgtca agtttggagg taccgggtaa atggagggga gctgcagagt     7380

tggaaaccca catgcatgga tgtgtccttg gcccagaacc accatgggat gggggaggcc     7440

ctgagccggc tacaagacac ccaggaagta ggcaaaggct gactttgcat taaacaataa     7500

aagcactttg agaaaacccc aacacttcag cctgggtccg tgtttctaca ctggaaaata     7560

cgagtctcct ttggctgtgt gaagtgatct tctagagact gggacaggga gtttgggaat     7620

ggggctgctg tcaggtagga gagagcagag atgcctttgg agatgtcagc agcaggagag     7680

ccagtgctgg ggccaaccct ttgctggcct tttgttggaa gcccttgaaa cagggagcca     7740

tgggtttaga tcttggtacc tacctttaca gaaagatgaa aacagcccag ctgagtgaaa     7800

tgagtttgta gagtaagtca cttaactgta agccatctca gaatcagaaa ccctaatgtt     7860

tcttacttgc tatgtgacct tgggcccctg tttcctcatc taccaaatga gaatgttgaa     7920

tatgagcatt aaagtccctt tcacctctga gaggctcaga tccccaacca ggagcattgg     7980

gaatccatca ctcctccttg aaactgattc cattctctga cttgacccag ctcctgttca     8040

gggtgagggt tctctgcaag aaccaaccag cagtaggttc aatcccactg tgtcctggct     8100

gagttgcctt atccaagaag accagctccc cgggacagat ctaagccata gtttctagtg     8160

gggacagtaa ggaattaaac ccccaacttg gctaggtaac gatgtcaaat ctcacattaa     8220

ccttgtcttt gtccccactg gatagctgtt aatccgaatg ttgtgaccat ttggctgttt     8280

ctctcttgtt ctcagacaat actagcaata cacttttttt tttttttttt aaagaaaaac     8340

agcttaggag cttttcacac atttctttca aatgattgta aaacatatgg ggcaacagga     8400

ggcattgatc gcgctgcata tgtttagggc agcttttgtt ttttgtttct ttaatggtat     8460

agcagcagtg actgagcctt cgtgattcct ggggacagct tttcagatac tctgtttcat     8520

cagtatgctt tgcacatccg gaaggagtac aaaaatccaa ctgcccaaat ttggggcttg     8580

gaaaataggt tttataggtg gtcggtccct gggctgtgca acaactcctc aaagaggggt     8640

ttatataact agaacccccc tgggctgtat ttttggtcaa aggagtctcc aaggcggctt     8700

acaaaagctt cctttttcac ttgaccaccc ttgctcattg gttacttgtg aagggaattg     8760

gtcagtttcc acctcagcac tttgccttat caacatgcgg tcgccatcta gtggccaaag     8820

gttgtctcca ccagctaccc agatggaagg caaataaatc ctttcggcca ccctgctgtc     8880

catcgtgaac tttgggaatg aaatataatg gcctgaacga actgcctttg tgttcagaga     8940

tcagtgcaac actagggtca gaagactcca gaagcagcca cttagtagac tctcacgcag     9000

aactgagaaa tgcactagct gtcctgtggg cagaagagac aggagtggac caggagaggt     9060

ccaggtgccc gggaagggtt tactgtaact gcaatactgg cagcccagct gctgaccttg     9120

ttaagtaaac ctttgctggg tggtccgaat tctgccctca aggcaagata agaagttggg     9180

tgtaaggatt ttgtgggggg cctggccatg atctttgata tgatccccga atagccaaat     9240

agtttttttt gttcaatttt ttgtttctgt attttgtatt tttaaaatct tgtcaaatgt     9300

ttttgtgtta ggaataaaaa gtcataaact attcccaact ttgtttcttg agggatgttc     9360

tgattccaat ggaaacaggt gggaaatctc aaggggagcg tggacaaggt ggtatgtgca     9420

gcaggggaat agactgcttg gatttccaaa tggtttctgg ggaagatgac catccagaag     9480

tccagcttag tgcagtctgc tctggaattc acacccaccc cctcgcctcc ttgtgccatg     9540

ttgttagcat tggcttggag catctgcttc ttccagaggc agctgctaat gttgaaacca     9600

acacgagccc tctccccaac cccaggtttc taaagaaggt gtctgtagcc agccttaatc     9660

aactgggcaa ggtggtccct atggtccttt ccagcatttc caaatcttgg actcaaatta     9720

ttttctcttg gtgtgaccac acagcctaga gaattctgag caataggagc cagggctttc     9780

cctgactctg cgacagggtc aaaccaagga atggctaaac ctgtgaggtt ttgtcatccc     9840

cgggggtact actgtagggg gcattattta ttaggaagct taacaaggta actacggcct     9900

gagtgcgtga gtgtaaggct gtgtttgtgg tgggggtgtg tgtgtgtgta tctgtgcaca     9960

catacacacg tctgtgcctg tgtgtgtgtg tttgtgtgtg tgtgtgtgtg tggaattaca    10020

ttgatgcatt tattgagaaa ggtgcaagaa tttcacctac acagagggac acatctgctt    10080

tgttatttat aatagaaagc taaattttaa ttttttaaag gacactgcta atgattgaga    10140

atcaagtttt tagttttgct atttttttta attggtagag gatttttata tattttttcc    10200

attttgttgg gttgtgtcct tatttatata aatactttat ccgtaagagg caaggaggaa    10260

accttctttg cttttacata ttgtggttgt catcgtccct attttatttc tggtgtgatt    10320

tctctgtctt accttctaaa tgagaaaatg ttttcttgta tttgtacatt gtcagattct    10380

atagtttcct agataattta accaaattgc tctatgtatt attattctgt gagtataaag    10440

ttctatttta atgtctgtaa atacttcaga actggcttct tttctcaaac tcccactgtg    10500

gggttattgt ttacatcaca gaaactgtag aatctctatg ctcatgtact gtaaatagtg    10560

aagtgatctg cttataaata aacttaacaa atacactatg gagattaaaa acaaaatacc    10620

acccacaaaa aaaaaaaaaa aa                                             10642


<210> 3
<211> 4815
<212> DNA
<213> human MITF Isoform

<220> 
<223> NM_198159

<400> 3
gtaaactccc cgcgctgggg cgggcggccg cgagccggcg agcgggcaga gctcggcact       60

gcgccggggc gcacggctcg ggggacccag gcccagctac cttccctccg cccccgggct      120

ctgttctcac tttccagcag tggaaggacg ggaagcggga gccatgcagt ccgaatcggg      180

gatcgtgccg gatttcgaag tcggggagga gtttcatgaa gagcccaaaa cctattacga      240

actcaaaagt caaccgctga agagcagcag ttccgccgag catcctgggg cctccaagcc      300

tccgataagc tcctccagta tgacatcacg catcttgcta cgccagcaac tcatgcgtga      360

gcagatgcag gagcaggagc gcagggagca gcagcagaag ctgcaggcgg cccagttcat      420

gcaacagaga gtgcccgtga gtcagacacc agccataaac gtcagtgtgc ccaccaccct      480

tccctctgcc acgcaggtgc cgatggaagt ccttaaggtg cagacccacc tcgaaaaccc      540

caccaagtac cacatacagc aagcccaacg gcagcaggta aagcagtacc tttctaccac      600

tttagcaaat aaacatgcca accaagtcct gagcttgcca tgtccaaacc agcctggcga      660

tcatgtcatg ccaccggtgc cggggagcag cgcacccaac agccccatgg ctatgcttac      720

gcttaactcc aactgtgaaa aagagggatt ttataagttt gaagagcaaa acagggcaga      780

gagcgagtgc ccaggcatga acacacattc acgagcgtcc tgtatgcaga tggatgatgt      840

aatcgatgac atcattagcc tagaatcaag ttataatgag gaaatcttgg gcttgatgga      900

tcctgctttg caaatggcaa atacgttgcc tgtctcggga aacttgattg atctttatgg      960

aaaccaaggt ctgcccccac caggcctcac catcagcaac tcctgtccag ccaaccttcc     1020

caacataaaa agggagctca cagagtctga agcaagagca ctggccaaag agaggcagaa     1080

aaaggacaat cacaacctga ttgaacgaag aagaagattt aacataaatg accgcattaa     1140

agaactaggt actttgattc ccaagtcaaa tgatccagac atgcgctgga acaagggaac     1200

catcttaaaa gcatccgtgg actatatccg aaagttgcaa cgagaacagc aacgcgcaaa     1260

agaacttgaa aaccgacaga agaaactgga gcacgccaac cggcatttgt tgctcagaat     1320

acaggaactt gaaatgcagg ctcgagctca tggactttcc cttattccat ccacgggtct     1380

ctgctctcca gatttggtga atcggatcat caagcaagaa cccgttcttg agaactgcag     1440

ccaagacctc cttcagcatc atgcagacct aacctgtaca acaactctcg atctcacgga     1500

tggcaccatc accttcaaca acaacctcgg aactgggact gaggccaacc aagcctatag     1560

tgtccccaca aaaatgggat ccaaactgga agacatcctg atggacgaca ccctttctcc     1620

cgtcggtgtc actgatccac tcctttcctc agtgtccccc ggagcttcca aaacaagcag     1680

ccggaggagc agtatgagca tggaagagac ggagcacact tgttagcgaa tcctccctgc     1740

actgcattcg cacaaactgc ttcctttctt gattcgtaga tttaataact tacctgaagg     1800

ggttttcttg ataattttcc tttaatatga aatttttttt catgctttat caatagccca     1860

ggatatattt tatttttaga attttgtgaa acagacttgt atattctatt ttacaactac     1920

aaatgcctcc aaagtattgt acaaataagt gtgcagtatc tgtgaactga attcaccaca     1980

gactttagct ttctgagcaa gaggattttg cgtcagagaa atgtctgtcc atttttattc     2040

aggggaaact tgatttgaga tttttatgcc tgtgacttcc ttggaaatca aatgtaaagt     2100

ttaattgaaa gaatgtaaag caaccaaaaa gaaaaaaaaa aagaaagaaa gaggaaaaga     2160

aatccatact aacccttttc cattttataa atgtattgat tcattggtac tgccttaaag     2220

atacagtacc cctctagctt tgtttagtct ttatactgca aactatttaa agaaatatgt     2280

attctgtaaa agaaaaaaaa aatgcggcct tttcatgagg atcgtctggt tagaaaacat     2340

aactgatacc aaccgaaact gaagggagtt agaccaaggc tctgaaatat aaagtctaat     2400

cttgctctct tttattctgt gctgttacag ttttcttcat caatgagtgt gatccagttt     2460

ttcataagat attttatttt gaaatggaaa ttaatgtcct ctcaaagtaa aatattgagg     2520

agcactgaaa gtatgtttta cttttttttt attttatttt tgcttttgat aagaaaaccg     2580

aactgggcat atttctaatt ggctttacta tttttatttt taaattatgt tttactgttc     2640

atttgatttg tacagattct ttattatcat tgttcttttc aatatatttg tattaatttg     2700

taagaatatg catcttaaaa tggcaagttt tccatatttt tacaactcac tggtggtttt     2760

ccgcattctt tgtacaccca tgaaagaaaa cttttatgca aggtcttgca tttaaaagac     2820

agctttgcga atattttgta aattacagtc tcactcagaa ctgtttttgg acacatttaa     2880

ggtgtagtat taataggtta aaaccaggct ttctagaaag aataaactta catatttatt     2940

tttaggacat gaaaatagca atattcttgg agattgataa ccatagcatt aatacgccca     3000

ttatggtcat ttaaattggg gtttatttca gcaaacttgt tgaatttatt tttaagaaag     3060

aaatactgta ttgggaagtt actgttactt gataacaatg ttttaacaag aagcaatgtt     3120

ataaagttag tttcagtgca ttatctactt gtgtagtcct atgcaataac agtagtgtta     3180

catgtatcaa gcctagatgt tttatacaga tgccatatag tgttatgagc caggctgttg     3240

aatggaattt ctcagtagca gcctacaact gaatagcaag tggcataaag catatccatt     3300

cagaatgaag tgccttaaat atagcagtag tcttttttgg actagcactg actgaactgt     3360

aatgtagggg aaagtttcat gatggtatct atagtcaaga cgaacatgta gcatggtgcc     3420

tatgtagaca atataagagc ttccaatttt ccttcagata tttttaatat taaatatatt     3480

ttagtgacag agtgccaact tctttcatca ggaaacctta ttcaggaggg tttttaaaaa     3540

gtgtttaaat gtcaaatgtg aattggtgat gggtgatgga gggttcagag aggagtgatc     3600

gtcagatgtg tgaatggacg gtttaggtga aaataatcaa ctgcatagtt cccatgcacg     3660

ctgggcaatg agaatccttg gaaacattgg tgatgctatc agttttatag ctttatttct     3720

taagggggta gggaaaatta gttcccattc tttcaacccc cttaactgta tagctctttt     3780

cctagaatag tgacgcaaat ctgcatgaac agctaattgt accatagtgt tcattgatac     3840

aatcatagca ttgtctattt ttctcttcat atttatatgg gggggagggc gctggatgca     3900

aaagttgaag atcgtgatgc tatgatgtta gttttcctta gctgattttg agggttttta     3960

aaaataaagc aaggttgact aacctacggc cacgggaaca ggaccatggt taagcaacca     4020

tatagaaagc tttgttgaaa gaaagtatgg catcttgtac cactgccctg actgtcacaa     4080

ctcctaacct tgccattgcc tgcctccccc tccccttctc cttaagagac aatttctgca     4140

ggtggcaggt gagcaagccc aggagaatgc tgcaatcttg ggggtggttt tatttatttc     4200

ttttttgcca aatagagtgt ggattcattt caggggctag ctaagccaag aggcagtggt     4260

ttgggcttgt tgtttgtaac aagaaaatga tccacaccac tcccccgatt cccgggtgca     4320

gaattgtaac tcggggttgg gcctctatat ggagtgacca aaatgccaaa attgtccatc     4380

tgcctctgag tagggcaatg gaaataccaa accttctgac tttgccaaaa agcatacaag     4440

caacctggtc atacatagga tgacaaaatt ctttctggtt gtttttaaac aataaagcaa     4500

taagaacaaa tacaatacat aggaagttaa aagcacaaag gaatgaactt attaatattt     4560

ttgaaaaatg cactgggaaa aagttgatgt caataacagt ataaaacagc cctatttctt     4620

gataaaaaat gacaaatgac tgtctcttgc ggatgcttgg tactgtaatg ttaataatag     4680

tcacctgctg ttggatgcag caataatttc tgtatggtcc atagcactgt atattatgga     4740

tcgatattaa tgtatccaat gaaataatcg acttgttctt gatagcctca ttaaagcatt     4800

tggtttttca catag                                                      4815


<210> 4
<211> 798
<212> PRT
<213> human PPARGC1A protein

<220> 
<223> Q9UBK2

<400> 4
Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      
Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          
Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              
Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  
Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  
Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      
Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         
Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             
Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 
Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 
Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     
Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         
Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             
Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 
Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 
Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     
Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         
Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             
Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala 
    290                 295                 300                 
Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 
305                 310                 315                 320 
Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser 
                325                 330                 335     
Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser 
            340                 345                 350         
Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His 
        355                 360                 365             
Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His 
    370                 375                 380                 
Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile 
385                 390                 395                 400 
Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser 
                405                 410                 415     
Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys 
            420                 425                 430         
Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser 
        435                 440                 445             
Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys 
    450                 455                 460                 
His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys 
465                 470                 475                 480 
Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys 
                485                 490                 495     
Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp 
            500                 505                 510         
Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr 
        515                 520                 525             
Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn 
    530                 535                 540                 
Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln 
545                 550                 555                 560 
Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg 
                565                 570                 575     
Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly 
            580                 585                 590         
Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr 
        595                 600                 605             
Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser 
    610                 615                 620                 
Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 
625                 630                 635                 640 
Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys 
                645                 650                 655     
Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala 
            660                 665                 670         
Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr 
        675                 680                 685             
Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu 
    690                 695                 700                 
Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile 
705                 710                 715                 720 
Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr 
                725                 730                 735     
Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly 
            740                 745                 750         
Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser 
        755                 760                 765             
Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp 
    770                 775                 780                 
Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
785                 790                 795             

<210> 5
<211> 984
<212> PRT
<213> human PPARGC1B protein

<220> 
<223> AAI44252

<400> 5
Met Ala Gly Asn Asp Cys Gly Ala Leu Leu Asp Glu Glu Leu Ser Ser 
1               5                   10                  15      
Phe Phe Leu Asn Tyr Leu Ala Asp Thr Gln Gly Gly Gly Ser Gly Glu 
            20                  25                  30          
Glu Gln Leu Tyr Ala Asp Phe Pro Glu Leu Asp Leu Ser Gln Leu Asp 
        35                  40                  45              
Ala Ser Asp Phe Asp Ser Ala Thr Cys Phe Gly Glu Leu Gln Trp Cys 
    50                  55                  60                  
Pro Glu Asn Ser Glu Thr Glu Pro Asn Gln Tyr Ser Pro Asp Asp Ser 
65                  70                  75                  80  
Glu Leu Phe Gln Ile Asp Ser Glu Asn Glu Ala Leu Leu Ala Glu Leu 
                85                  90                  95      
Thr Lys Thr Leu Asp Asp Ile Pro Glu Asp Asp Val Gly Leu Ala Ala 
            100                 105                 110         
Phe Pro Ala Leu Asp Gly Gly Asp Ala Leu Ser Cys Thr Ser Ala Ser 
        115                 120                 125             
Pro Ala Pro Ser Ser Ala Pro Pro Ser Pro Ala Pro Glu Lys Pro Ser 
    130                 135                 140                 
Ala Pro Ala Pro Glu Val Asp Glu Leu Ser Leu Ala Asp Ser Thr Gln 
145                 150                 155                 160 
Asp Lys Lys Ala Pro Met Met Gln Ser Gln Ser Arg Ser Cys Thr Glu 
                165                 170                 175     
Leu His Lys His Leu Thr Ser Ala Gln Cys Cys Leu Gln Asp Arg Gly 
            180                 185                 190         
Leu Gln Pro Pro Cys Leu Gln Ser Pro Arg Leu Pro Ala Lys Glu Asp 
        195                 200                 205             
Lys Glu Pro Gly Glu Asp Cys Pro Ser Pro Gln Pro Ala Pro Ala Ser 
    210                 215                 220                 
Pro Arg Asp Ser Leu Ala Leu Gly Arg Ala Asp Pro Gly Ala Pro Val 
225                 230                 235                 240 
Ser Gln Glu Asp Met Gln Ala Met Val Gln Leu Ile Ser Tyr Met His 
                245                 250                 255     
Thr Tyr Cys Leu Pro Gln Arg Lys Leu Pro Pro Gln Thr Pro Glu Pro 
            260                 265                 270         
Leu Pro Lys Ala Cys Ser Asn Pro Ser Gln Gln Val Arg Ser Arg Pro 
        275                 280                 285             
Trp Ser Arg His His Ser Lys Ala Ser Trp Ala Glu Phe Ser Ile Leu 
    290                 295                 300                 
Arg Glu Leu Leu Ala Gln Asp Val Leu Cys Asp Val Ser Lys Pro Tyr 
305                 310                 315                 320 
Arg Leu Ala Thr Pro Val Tyr Ala Ser Leu Thr Pro Arg Ser Arg Pro 
                325                 330                 335     
Arg Pro Pro Lys Asp Ser Gln Ala Ser Pro Gly Arg Pro Ser Ser Val 
            340                 345                 350         
Glu Glu Val Arg Ile Ala Ala Ser Pro Lys Ser Thr Gly Pro Arg Pro 
        355                 360                 365             
Ser Leu Arg Pro Leu Arg Leu Glu Val Lys Arg Glu Val Arg Arg Pro 
    370                 375                 380                 
Ala Arg Leu Gln Gln Gln Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu 
385                 390                 395                 400 
Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu Glu Trp Gly Arg Lys Arg 
                405                 410                 415     
Pro Gly Arg Gly Leu Pro Trp Thr Lys Leu Gly Arg Lys Leu Glu Ser 
            420                 425                 430         
Ser Val Cys Pro Val Arg Arg Ser Arg Arg Leu Asn Pro Glu Leu Gly 
        435                 440                 445             
Pro Trp Leu Thr Phe Ala Asp Glu Pro Leu Val Pro Ser Glu Pro Gln 
    450                 455                 460                 
Gly Ala Leu Pro Ser Leu Cys Leu Ala Pro Lys Ala Tyr Asp Val Glu 
465                 470                 475                 480 
Arg Glu Leu Gly Ser Pro Thr Asp Glu Asp Ser Gly Gln Asp Gln Gln 
                485                 490                 495     
Leu Leu Arg Gly Pro Gln Ile Pro Ala Leu Glu Ser Pro Cys Glu Ser 
            500                 505                 510         
Gly Cys Gly Asp Met Asp Glu Asp Pro Ser Cys Pro Gln Leu Pro Pro 
        515                 520                 525             
Arg Asp Ser Pro Arg Cys Leu Met Leu Ala Leu Ser Gln Ser Asp Pro 
    530                 535                 540                 
Thr Phe Gly Lys Lys Ser Phe Glu Gln Thr Leu Thr Val Glu Leu Cys 
545                 550                 555                 560 
Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro Tyr Lys Pro Thr 
                565                 570                 575     
Glu Glu Asp Pro Phe Lys Pro Asp Ile Lys His Ser Leu Gly Lys Glu 
            580                 585                 590         
Ile Ala Leu Ser Leu Pro Ser Pro Glu Gly Leu Ser Leu Lys Ala Thr 
        595                 600                 605             
Pro Gly Ala Ala His Lys Leu Pro Lys Lys His Pro Glu Arg Ser Glu 
    610                 615                 620                 
Leu Leu Ser His Leu Arg His Ala Thr Ala Gln Pro Ala Ser Gln Ala 
625                 630                 635                 640 
Gly Gln Lys Arg Pro Phe Ser Cys Ser Phe Gly Asp His Asp Tyr Cys 
                645                 650                 655     
Gln Val Leu Arg Pro Glu Gly Val Leu Gln Arg Lys Val Leu Arg Ser 
            660                 665                 670         
Trp Glu Pro Ser Gly Val His Leu Glu Asp Trp Pro Gln Gln Gly Ala 
        675                 680                 685             
Pro Trp Ala Glu Ala Gln Ala Pro Gly Arg Glu Glu Asp Arg Ser Cys 
    690                 695                 700                 
Asp Ala Gly Ala Pro Pro Lys Asp Ser Thr Leu Leu Arg Asp His Glu 
705                 710                 715                 720 
Ile Arg Ala Ser Leu Thr Lys His Phe Gly Leu Leu Glu Thr Ala Leu 
                725                 730                 735     
Glu Glu Glu Asp Leu Ala Ser Cys Lys Ser Pro Glu Tyr Asp Thr Val 
            740                 745                 750         
Phe Glu Asp Ser Ser Ser Ser Ser Gly Glu Ser Ser Phe Leu Pro Glu 
        755                 760                 765             
Glu Glu Glu Glu Glu Gly Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu 
    770                 775                 780                 
Asp Ser Gly Val Ser Pro Thr Cys Ser Asp His Cys Pro Tyr Gln Ser 
785                 790                 795                 800 
Pro Pro Ser Lys Ala Asn Arg Gln Leu Cys Ser Arg Ser Arg Ser Ser 
                805                 810                 815     
Ser Gly Ser Ser Pro Cys His Ser Trp Ser Pro Ala Thr Arg Arg Asn 
            820                 825                 830         
Phe Arg Cys Glu Ser Arg Gly Pro Cys Ser Asp Arg Thr Pro Ser Ile 
        835                 840                 845             
Arg His Ala Arg Lys Arg Arg Glu Lys Ala Ile Gly Glu Gly Arg Val 
    850                 855                 860                 
Val Tyr Ile Gln Asn Leu Ser Ser Asp Met Ser Ser Arg Glu Leu Lys 
865                 870                 875                 880 
Arg Arg Phe Glu Val Phe Gly Glu Ile Glu Glu Cys Glu Val Leu Thr 
                885                 890                 895     
Arg Asn Arg Arg Gly Glu Lys Tyr Gly Phe Ile Thr Tyr Arg Cys Ser 
            900                 905                 910         
Glu His Ala Ala Leu Ser Leu Thr Lys Gly Ala Ala Leu Arg Lys Arg 
        915                 920                 925             
Asn Glu Pro Ser Phe Gln Leu Ser Tyr Gly Gly Leu Arg His Phe Cys 
    930                 935                 940                 
Trp Pro Arg Tyr Thr Asp Tyr Asp Ser Asn Ser Glu Glu Ala Leu Ser 
945                 950                 955                 960 
Ala Ser Gly Lys Ser Lys Tyr Glu Ala Met Asp Phe Asp Ser Leu Leu 
                965                 970                 975     
Lys Glu Ala Gln Gln Ser Leu His 
            980                 

<210> 6
<211> 526
<212> PRT
<213> human MITF protein

<220> 
<223> NP-937802

<400> 6
Met Gln Ser Glu Ser Gly Ile Val Pro Asp Phe Glu Val Gly Glu Glu 
1               5                   10                  15      
Phe His Glu Glu Pro Lys Thr Tyr Tyr Glu Leu Lys Ser Gln Pro Leu 
            20                  25                  30          
Lys Ser Ser Ser Ser Ala Glu His Pro Gly Ala Ser Lys Pro Pro Ile 
        35                  40                  45              
Ser Ser Ser Ser Met Thr Ser Arg Ile Leu Leu Arg Gln Gln Leu Met 
    50                  55                  60                  
Arg Glu Gln Met Gln Glu Gln Glu Arg Arg Glu Gln Gln Gln Lys Leu 
65                  70                  75                  80  
Gln Ala Ala Gln Phe Met Gln Gln Arg Val Pro Val Ser Gln Thr Pro 
                85                  90                  95      
Ala Ile Asn Val Ser Val Pro Thr Thr Leu Pro Ser Ala Thr Gln Val 
            100                 105                 110         
Pro Met Glu Val Leu Lys Val Gln Thr His Leu Glu Asn Pro Thr Lys 
        115                 120                 125             
Tyr His Ile Gln Gln Ala Gln Arg Gln Gln Val Lys Gln Tyr Leu Ser 
    130                 135                 140                 
Thr Thr Leu Ala Asn Lys His Ala Asn Gln Val Leu Ser Leu Pro Cys 
145                 150                 155                 160 
Pro Asn Gln Pro Gly Asp His Val Met Pro Pro Val Pro Gly Ser Ser 
                165                 170                 175     
Ala Pro Asn Ser Pro Met Ala Met Leu Thr Leu Asn Ser Asn Cys Glu 
            180                 185                 190         
Lys Glu Gly Phe Tyr Lys Phe Glu Glu Gln Asn Arg Ala Glu Ser Glu 
        195                 200                 205             
Cys Pro Gly Met Asn Thr His Ser Arg Ala Ser Cys Met Gln Met Asp 
    210                 215                 220                 
Asp Val Ile Asp Asp Ile Ile Ser Leu Glu Ser Ser Tyr Asn Glu Glu 
225                 230                 235                 240 
Ile Leu Gly Leu Met Asp Pro Ala Leu Gln Met Ala Asn Thr Leu Pro 
                245                 250                 255     
Val Ser Gly Asn Leu Ile Asp Leu Tyr Gly Asn Gln Gly Leu Pro Pro 
            260                 265                 270         
Pro Gly Leu Thr Ile Ser Asn Ser Cys Pro Ala Asn Leu Pro Asn Ile 
        275                 280                 285             
Lys Arg Glu Leu Thr Ala Cys Ile Phe Pro Thr Glu Ser Glu Ala Arg 
    290                 295                 300                 
Ala Leu Ala Lys Glu Arg Gln Lys Lys Asp Asn His Asn Leu Ile Glu 
305                 310                 315                 320 
Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys Glu Leu Gly Thr 
                325                 330                 335     
Leu Ile Pro Lys Ser Asn Asp Pro Asp Met Arg Trp Asn Lys Gly Thr 
            340                 345                 350         
Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys Leu Gln Arg Glu Gln 
        355                 360                 365             
Gln Arg Ala Lys Glu Leu Glu Asn Arg Gln Lys Lys Leu Glu His Ala 
    370                 375                 380                 
Asn Arg His Leu Leu Leu Arg Ile Gln Glu Leu Glu Met Gln Ala Arg 
385                 390                 395                 400 
Ala His Gly Leu Ser Leu Ile Pro Ser Thr Gly Leu Cys Ser Pro Asp 
                405                 410                 415     
Leu Val Asn Arg Ile Ile Lys Gln Glu Pro Val Leu Glu Asn Cys Ser 
            420                 425                 430         
Gln Asp Leu Leu Gln His His Ala Asp Leu Thr Cys Thr Thr Thr Leu 
        435                 440                 445             
Asp Leu Thr Asp Gly Thr Ile Thr Phe Asn Asn Asn Leu Gly Thr Gly 
    450                 455                 460                 
Thr Glu Ala Asn Gln Ala Tyr Ser Val Pro Thr Lys Met Gly Ser Lys 
465                 470                 475                 480 
Leu Glu Asp Ile Leu Met Asp Asp Thr Leu Ser Pro Val Gly Val Thr 
                485                 490                 495     
Asp Pro Leu Leu Ser Ser Val Ser Pro Gly Ala Ser Lys Thr Ser Ser 
            500                 505                 510         
Arg Arg Ser Ser Met Ser Met Glu Glu Thr Glu His Thr Cys 
        515                 520                 525     

