                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120>  INHIBITORS OF PROTOTYPIC GALECTIN DIMERIZATION AND USES THEREOF

<130>  782/16398.11

<150>  US 62/167,512
<151>  2015-05-28

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Asp Ser Val Arg Ile Phe 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  2

Leu Asp Ser Val Arg Ile Phe 
1               5           


<210>  3
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Arg Pro Gly Thr Val Leu Arg Ile Arg Gly Leu Val 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  4

Ile Arg Pro Gly Thr Val Leu Arg Ile Arg Gly Leu Val 
1               5                   10              


<210>  5
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Gly Phe Lys Ala Val Val Gly Asp Ala Gln Tyr His His 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  6

Asp Gly Phe Lys Ala Val Val Gly Asp Ala Gln Tyr His His 
1               5                   10                  


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Glu Val Leu Ile Ile Ala Ser Asp Asp Gly Phe Lys Ala Val Val 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  8

Phe Glu Val Leu Ile Ile Ala Ser Asp Asp Gly Phe Lys Ala Val Val 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  9

Leu Ala Ser Val Arg Ile Phe 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  10

Leu Asp Ala Val Arg Ile Phe 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  11

Leu Asp Ser Val Ala Ile Phe 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  AMIDATION

<400>  12

Leu Asp Ser Val Arg Ile Ala 
1               5           


<210>  13
<211>  515
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (26)..(436)

<400>  13
acggctgccc aacccggtcc cagcc atg tcc aac gtc ccc cac aag tcc tca         52
                            Met Ser Asn Val Pro His Lys Ser Ser           
                            1               5                             

ctg ccc gag ggc atc cgc cct ggc acg gtg ctg aga att cgc ggc ttg        100
Leu Pro Glu Gly Ile Arg Pro Gly Thr Val Leu Arg Ile Arg Gly Leu           
10                  15                  20                  25            

gtt cct ccc aat gcc agc agg ttc cat gta aac ctg ctg tgc ggg gag        148
Val Pro Pro Asn Ala Ser Arg Phe His Val Asn Leu Leu Cys Gly Glu           
                30                  35                  40                

gag cag ggc tcc gat gcc gcg ctg cat ttc aac ccc cgg ctg gac acg        196
Glu Gln Gly Ser Asp Ala Ala Leu His Phe Asn Pro Arg Leu Asp Thr           
            45                  50                  55                    

tcg gag gtg gtc ttc aac agc aag gag caa ggc tcc tgg ggc cgc gag        244
Ser Glu Val Val Phe Asn Ser Lys Glu Gln Gly Ser Trp Gly Arg Glu           
        60                  65                  70                        

gag cgc ggg ccg ggc gtt cct ttc cag cgc ggg cag ccc ttc gag gtg        292
Glu Arg Gly Pro Gly Val Pro Phe Gln Arg Gly Gln Pro Phe Glu Val           
    75                  80                  85                            

ctc atc atc gcg tca gac gac ggc ttc aag gcc gtg gtt ggg gac gcc        340
Leu Ile Ile Ala Ser Asp Asp Gly Phe Lys Ala Val Val Gly Asp Ala           
90                  95                  100                 105           

cag tac cac cac ttc cgc cac cgc ctg ccg ctg gcg cgc gtg cgc ctg        388
Gln Tyr His His Phe Arg His Arg Leu Pro Leu Ala Arg Val Arg Leu           
                110                 115                 120               

gtg gag gtg ggc ggg gac gtg cag ctg gac tcc gtg agg atc ttc tga        436
Val Glu Val Gly Gly Asp Val Gln Leu Asp Ser Val Arg Ile Phe               
            125                 130                 135                   

gcagaagccc aggcgggccc ggggccttgg ctggcaaata aagcgttagc ccgcagcgaa      496

aaaaaaaaaa aaaaaaaaa                                                   515


<210>  14
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Asn Val Pro His Lys Ser Ser Leu Pro Glu Gly Ile Arg Pro 
1               5                   10                  15      


Gly Thr Val Leu Arg Ile Arg Gly Leu Val Pro Pro Asn Ala Ser Arg 
            20                  25                  30          


Phe His Val Asn Leu Leu Cys Gly Glu Glu Gln Gly Ser Asp Ala Ala 
        35                  40                  45              


Leu His Phe Asn Pro Arg Leu Asp Thr Ser Glu Val Val Phe Asn Ser 
    50                  55                  60                  


Lys Glu Gln Gly Ser Trp Gly Arg Glu Glu Arg Gly Pro Gly Val Pro 
65                  70                  75                  80  


Phe Gln Arg Gly Gln Pro Phe Glu Val Leu Ile Ile Ala Ser Asp Asp 
                85                  90                  95      


Gly Phe Lys Ala Val Val Gly Asp Ala Gln Tyr His His Phe Arg His 
            100                 105                 110         


Arg Leu Pro Leu Ala Arg Val Arg Leu Val Glu Val Gly Gly Asp Val 
        115                 120                 125             


Gln Leu Asp Ser Val Arg Ile Phe 
    130                 135     


<210>  15
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  16
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Gly Glu Leu Glu Val Lys Asn Met Asp Met Lys Pro Gly Ser 
1               5                   10                  15      


Thr Leu Lys Ile Thr Gly Ser Ile Ala Asp Gly Thr Asp Gly Phe Val 
            20                  25                  30          


Ile Asn Leu Gly Gln Gly Thr Asp Lys Leu Asn Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Ser Glu Ser Thr Ile Val Cys Asn Ser Leu Asp Gly Ser Asn 
    50                  55                  60                  


Trp Gly Gln Glu Gln Arg Glu Asp His Leu Cys Phe Ser Pro Gly Ser 
65                  70                  75                  80  


Glu Val Lys Phe Thr Val Thr Phe Glu Ser Asp Lys Phe Lys Val Lys 
                85                  90                  95      


Leu Pro Asp Gly His Glu Leu Thr Phe Pro Asn Arg Leu Gly His Ser 
            100                 105                 110         


His Leu Ser Tyr Leu Ser Val Arg Gly Gly Phe Asn Met Ser Ser Phe 
        115                 120                 125             


Lys Leu Lys Glu 
    130         


<210>  17
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Leu Leu Pro Val Pro Tyr Thr Glu Ala Ala Ser Leu Ser Thr 
1               5                   10                  15      


Gly Ser Thr Val Thr Ile Lys Gly Arg Pro Leu Ala Cys Phe Leu Asn 
            20                  25                  30          


Glu Pro Tyr Leu Gln Val Asp Phe His Thr Glu Met Lys Glu Glu Ser 
        35                  40                  45              


Asp Ile Val Phe His Phe Gln Val Cys Phe Gly Arg Arg Val Val Met 
    50                  55                  60                  


Asn Ser Arg Glu Tyr Gly Ala Trp Lys Gln Gln Val Glu Ser Lys Asn 
65                  70                  75                  80  


Met Pro Phe Gln Asp Gly Gln Glu Phe Glu Leu Ser Ile Ser Val Leu 
                85                  90                  95      


Pro Asp Lys Tyr Gln Val Met Val Asn Gly Gln Ser Ser Tyr Thr Phe 
            100                 105                 110         


Asp His Arg Ile Lys Pro Glu Ala Val Lys Met Val Gln Val Trp Arg 
        115                 120                 125             


Asp Ile Ser Leu Thr Lys Phe Asn Val Ser Tyr Leu Lys Arg 
    130                 135                 140         


<210>  18
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Ser Leu Pro Val Pro Tyr Lys Leu Pro Val Ser Leu Ser Val 
1               5                   10                  15      


Gly Ser Cys Val Ile Ile Lys Gly Thr Pro Ile His Ser Phe Ile Asn 
            20                  25                  30          


Asp Pro Gln Leu Gln Val Asp Phe Tyr Thr Asp Met Asp Glu Asp Ser 
        35                  40                  45              


Asp Ile Ala Phe Arg Phe Arg Val His Phe Gly Asn His Val Val Met 
    50                  55                  60                  


Asn Arg Arg Glu Phe Gly Ile Trp Met Leu Glu Glu Thr Thr Asp Tyr 
65                  70                  75                  80  


Val Pro Phe Glu Asp Gly Lys Gln Phe Glu Leu Cys Ile Tyr Val His 
                85                  90                  95      


Tyr Asn Glu Tyr Glu Ile Lys Val Asn Gly Ile Arg Ile Tyr Gly Phe 
            100                 105                 110         


Val His Arg Ile Pro Pro Ser Phe Val Lys Met Val Gln Val Ser Arg 
        115                 120                 125             


Asp Ile Ser Leu Thr Ser Val Cys Val Cys Asn 
    130                 135                 


<210>  19
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Ser Leu Pro Val Pro Tyr Thr Leu Pro Val Ser Leu Pro Val 
1               5                   10                  15      


Gly Ser Cys Val Ile Ile Thr Gly Thr Pro Ile Leu Thr Phe Val Lys 
            20                  25                  30          


Asp Pro Gln Leu Glu Val Asn Phe Tyr Thr Gly Met Asp Glu Asp Ser 
        35                  40                  45              


Asp Ile Ala Phe Gln Phe Arg Leu His Phe Gly His Pro Ala Ile Met 
    50                  55                  60                  


Asn Ser Cys Val Phe Gly Ile Trp Arg Tyr Glu Glu Lys Cys Tyr Tyr 
65                  70                  75                  80  


Leu Pro Phe Glu Asp Gly Lys Pro Phe Glu Leu Cys Ile Tyr Val Arg 
                85                  90                  95      


His Lys Glu Tyr Lys Val Met Val Asn Gly Gln Arg Ile Tyr Asn Phe 
            100                 105                 110         


Ala His Arg Phe Pro Pro Ala Ser Val Lys Met Leu Gln Val Phe Arg 
        115                 120                 125             


Asp Ile Ser Leu Thr Arg Val Leu Ile Ser Asp 
    130                 135                 


