                         SEQUENCE LISTING

<110>  Viventia Bio, Inc.
       Dillon, Rachelle L.
       Chooniedass, Shilpa
       Cizeau, Jeannick
       Premsukh, Arjune
       MacDonald , Glen C.
 
<120>  HER2 IMMUNOTOXINS AND METHODS OF USING THE SAME

<130>  VIVE-032/01WO

<150>  US 62/164,444
<151>  2015-05-20

<150>  US 62/278,905
<151>  2016-01-14

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  387
<212>  DNA
<213>  artificial

<220>
<223>  VH C6.5 nucleotide sequence

<400>  1
caggtgcagc tggtgcagtc tggggcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcgcctgggt gcgccagatg      120

cccgggaaag gcctggagta catggggctc atctatcctg gtgactctga caccaaatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagtcgaca agtccgtcag cactgcctac      240

ttgcaatgga gcagtctgaa gccctcggac agcgccgtgt atttttgtgc gagacatgac      300

gtgggatatt gcagtagttc caactgcgca aagtggcctg aatacttcca gcattggggc      360

cagggcaccc tggtcaccgt ttcctca                                          387


<210>  2
<211>  129
<212>  PRT
<213>  artificial

<220>
<223>  VH C6.5 amino acid sequence

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Asp Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp 
            100                 105                 110         


Pro Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  3
<211>  333
<212>  DNA
<213>  artificial

<220>
<223>  VL C6.5 nucleotide sequence

<400>  3
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag tccccaaact cctcatctat ggtcacacca atcggcccgc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggttccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggt                                   333


<210>  4
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  VL C6.5 amino acid sequence

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly His Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  5
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  VH C6.5 CDR1

<400>  5

Ser Tyr Trp Ile Ala 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  VH C6.5 CDR2

<400>  6

Leu Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  VH C6.5 CDR3

<400>  7

His Asp Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp Pro Glu 
1               5                   10                  15      


Tyr Phe Gln His 
            20  


<210>  8
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  VL C6.5 CDR1

<400>  8

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  9
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  VL C6.5 CDR2

<400>  9

Gly His Thr Asn Arg Pro Ala 
1               5           


<210>  10
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  VL C6.5 CDR3

<400>  10

Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  11
<211>  750
<212>  DNA
<213>  artificial

<220>
<223>  deBouganin nucleotide sequence

<400>  11
tacaacactg tgtcatttaa ccttggagaa gcttatgagt accccacttt tatacaagat       60

ttgcgcaatg aattggctaa gggcacacca gtatgtcaac ttccagtgac actacaaacc      120

atagccgatg acaagcgatt tgttctagtt gatatcacta cgacctcgaa gaaaacagtt      180

aaggttgcta tagatgtgac agatgtgtat gttgtgggtt atcaagacaa atgggatggc      240

aaagatcgag ctgttttcct tgacaaggtt cctactgttg caactagtaa acttttccca      300

ggggtgacta atcgtgtaac gttaacattt gatggcagct atcagaaact tgtgaatgct      360

gccaaagctg atagaaaggc tctcgaactg ggggttaaca aattggaatt ttccattgaa      420

gcaatccatg gtaaaacgat aaatggtcaa gaggcagcca agttctttct tattgtcatc      480

caaatggttt cagaggcagc tcggttcaaa tatattgaga ctgaggtggt tgatagagga      540

ttatatggat cattcaaacc taattttaaa gtattgaact tggagaacaa ctggggcgac      600

atctctgatg ccattcacaa atcatcccca caatgtacca ctattaatcc ggcacttcag      660

ttgataagcc cctcaaatga cccatgggtt gtaaataaag tgagtcaaat tagtcccgat      720

atgggtatcc ttaagtttaa aagctccaaa                                       750


<210>  12
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin amino acid sequence

<400>  12

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  13
<211>  756
<212>  DNA
<213>  artificial

<220>
<223>  deBouganin nucleotide sequence codon optimized

<400>  13
tataacaccg tatcttttaa cctgggtgag gcgtatgaat acccgacctt catccaggac       60

ctgcgtaatg aacttgctaa aggtacccct gtttgccagc tgcctgtgac cctgcagacc      120

atcgctgatg ataaacgttt cgttctggtt gacattacca ccacctccaa aaaaaccgtt      180

aaagtcgcga tcgatgtgac cgacgtttac gtggtaggtt accaggataa atgggacggt      240

aaagatcgtg cggttttcct ggacaaagtt ccgaccgtag cgacttctaa actgttccca      300

ggtgtgacca accgtgtgac cctgaccttc gacggcagct atcagaaact ggttaacgcg      360

gccaaagctg atcgtaaagc tctcgaactg ggtgttaaca aactggagtt cagcattgaa      420

gctatccacg gtaaaaccat caacggtcaa gaagcagcta aattcttcct gatcgtgatc      480

cagatggtta gcgaagcagc gcgttttaaa tacattgaaa ccgaagtagt tgatcgtggt      540

ctgtatggta gcttcaaacc gaacttcaaa gttcttaacc tggagaacaa ctggggtgac      600

attagcgacg cgatccataa atcttccccg caatgcacca ccattaaccc ggctctgcag      660

ctgatctctc cgtctaacga tccgtgggta gttaacaaag tgtctcaaat cagcccggac      720

atgggtatcc tgaaatttaa atctagcaaa tagtga                                756


<210>  14
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  linker nucleotide sequence

<400>  14
ggtggaggcg gttca                                                        15


<210>  15
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  linker amino acid sequence

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-WT modified nucleotide sequence

<400>  16
acgcgtcaca ggcagcccag aggctgggag caattg                                 36


<210>  17
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Furin linker-WT amino acid sequence

<400>  17

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
1               5                   10          


<210>  18
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  6xHIS nucleotide sequence

<400>  18
catcaccacc accaccat                                                     18


<210>  19
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  6xHIS amino acid sequence

<400>  19

His His His His His His 
1               5       


<210>  20
<211>  66
<212>  DNA
<213>  artificial

<220>
<223>  PelB leader nucleotide sequence

<400>  20
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgctgc ccaaccagcg       60

atggcg                                                                  66


<210>  21
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  PelB leader amino acid sequence

<400>  21

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  22
<211>  1682
<212>  DNA
<213>  artificial

<220>
<223>  PelB-deBouganin-F-AvP07-17(VH-VL-C6.5)-His NT

<400>  22
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaattgcag gtgcagctgg tgcagtctgg ggcagaggtg aaaaagcccg      960

gggagtctct gaagatctcc tgtaagggtt ctggatacag ctttaccagc tactggatcg     1020

cctgggtgcg ccagatgccc gggaaaggcc tggagtacat ggggctcatc tatcctggtg     1080

actctgacac caaatacagc ccgtccttcc aaggccaggt caccatctca gtcgacaagt     1140

ccgtcagcac tgcctacttg caatggagca gtctgaagcc ctcggacagc gccgtgtatt     1200

tttgtgcgag acatgacgtg ggatattgca gtagttccaa ctgcgcaaag tggcctgaat     1260

acttccagca ttggggccag ggcaccctgg tcaccgtttc ctcaggtgga ggcggttcac     1320

agtctgtgtt gacgcagccg ccctcagtgt ctgcggcccc aggacagaag gtcaccatct     1380

cctgctctgg aagcagctcc aacattggga ataattatgt atcctggtac cagcagctcc     1440

caggaacagt ccccaaactc ctcatctatg gtcacaccaa tcggcccgca ggggtccctg     1500

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggttccggt     1560

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttgggtgt     1620

tcggcggagg gaccaagctg accgtcctag gtcatcacca ccaccaccat tagtgactcg     1680

ag                                                                    1682


<210>  23
<211>  535
<212>  PRT
<213>  artificial

<220>
<223>  PelB-deBouganin-F-AvP07-17(VH-VL-C6.5)-His AA

<400>  23

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu 
            20                  25                  30          


Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala 
        35                  40                  45              


Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile Ala 
    50                  55                  60                  


Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys Lys 
65                  70                  75                  80  


Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly Tyr 
                85                  90                  95      


Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys Val 
            100                 105                 110         


Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg Val 
        115                 120                 125             


Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys 
    130                 135                 140                 


Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe Ser 
145                 150                 155                 160 


Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys 
                165                 170                 175     


Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe Lys 
            180                 185                 190         


Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys 
        195                 200                 205             


Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser 
    210                 215                 220                 


Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala 
225                 230                 235                 240 


Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys Val 
                245                 250                 255     


Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Gln Val Gln Leu 
        275                 280                 285             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile 
    290                 295                 300                 


Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp 
305                 310                 315                 320 


Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr 
                325                 330                 335     


Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val 
            340                 345                 350         


Thr Ile Ser Val Asp Lys Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser 
        355                 360                 365             


Ser Leu Lys Pro Ser Asp Ser Ala Val Tyr Phe Cys Ala Arg His Asp 
    370                 375                 380                 


Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe 
385                 390                 395                 400 


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro 
            420                 425                 430         


Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly 
        435                 440                 445             


Asn Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys 
    450                 455                 460                 


Leu Leu Ile Tyr Gly His Thr Asn Arg Pro Ala Gly Val Pro Asp Arg 
465                 470                 475                 480 


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
                485                 490                 495     


Phe Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
            500                 505                 510         


Ser Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        515                 520                 525             


Gly His His His His His His 
    530                 535 


<210>  24
<211>  1664
<212>  DNA
<213>  artificial

<220>
<223>  PelB-deBouganin-F-AvP07-17(VH-VL-C6.5)NT

<400>  24
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaattgcag gtgcagctgg tgcagtctgg ggcagaggtg aaaaagcccg      960

gggagtctct gaagatctcc tgtaagggtt ctggatacag ctttaccagc tactggatcg     1020

cctgggtgcg ccagatgccc gggaaaggcc tggagtacat ggggctcatc tatcctggtg     1080

actctgacac caaatacagc ccgtccttcc aaggccaggt caccatctca gtcgacaagt     1140

ccgtcagcac tgcctacttg caatggagca gtctgaagcc ctcggacagc gccgtgtatt     1200

tttgtgcgag acatgacgtg ggatattgca gtagttccaa ctgcgcaaag tggcctgaat     1260

acttccagca ttggggccag ggcaccctgg tcaccgtttc ctcaggtgga ggcggttcac     1320

agtctgtgtt gacgcagccg ccctcagtgt ctgcggcccc aggacagaag gtcaccatct     1380

cctgctctgg aagcagctcc aacattggga ataattatgt atcctggtac cagcagctcc     1440

caggaacagt ccccaaactc ctcatctatg gtcacaccaa tcggcccgca ggggtccctg     1500

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggttccggt     1560

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttgggtgt     1620

tcggcggagg gaccaagctg accgtcctag gttagtgact cgag                      1664


<210>  25
<211>  529
<212>  PRT
<213>  artificial

<220>
<223>  PelB-deBouganin-F-AvP07-17(VH-VL-C6.5) AA

<400>  25

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu 
            20                  25                  30          


Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala 
        35                  40                  45              


Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile Ala 
    50                  55                  60                  


Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys Lys 
65                  70                  75                  80  


Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly Tyr 
                85                  90                  95      


Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys Val 
            100                 105                 110         


Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg Val 
        115                 120                 125             


Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys 
    130                 135                 140                 


Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe Ser 
145                 150                 155                 160 


Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys 
                165                 170                 175     


Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe Lys 
            180                 185                 190         


Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys 
        195                 200                 205             


Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser 
    210                 215                 220                 


Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala 
225                 230                 235                 240 


Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys Val 
                245                 250                 255     


Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Gln Val Gln Leu 
        275                 280                 285             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile 
    290                 295                 300                 


Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp 
305                 310                 315                 320 


Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr 
                325                 330                 335     


Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val 
            340                 345                 350         


Thr Ile Ser Val Asp Lys Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser 
        355                 360                 365             


Ser Leu Lys Pro Ser Asp Ser Ala Val Tyr Phe Cys Ala Arg His Asp 
    370                 375                 380                 


Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe 
385                 390                 395                 400 


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro 
            420                 425                 430         


Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly 
        435                 440                 445             


Asn Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys 
    450                 455                 460                 


Leu Leu Ile Tyr Gly His Thr Asn Arg Pro Ala Gly Val Pro Asp Arg 
465                 470                 475                 480 


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
                485                 490                 495     


Phe Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
            500                 505                 510         


Ser Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        515                 520                 525             


Gly 
    


<210>  26
<211>  1682
<212>  DNA
<213>  artificial

<220>
<223>  PelB-AvP07-17-(VH-VL-C6.5)-F-deBouganin-His NT

<400>  26
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gcaggtgcag ctggtgcagt ctggggcaga ggtgaaaaag cccggggagt      180

ctctgaagat ctcctgtaag ggttctggat acagctttac cagctactgg atcgcctggg      240

tgcgccagat gcccgggaaa ggcctggagt acatggggct catctatcct ggtgactctg      300

acaccaaata cagcccgtcc ttccaaggcc aggtcaccat ctcagtcgac aagtccgtca      360

gcactgccta cttgcaatgg agcagtctga agccctcgga cagcgccgtg tatttttgtg      420

cgagacatga cgtgggatat tgcagtagtt ccaactgcgc aaagtggcct gaatacttcc      480

agcattgggg ccagggcacc ctggtcaccg tttcctcagg tggaggcggt tcacagtctg      540

tgttgacgca gccgccctca gtgtctgcgg ccccaggaca gaaggtcacc atctcctgct      600

ctggaagcag ctccaacatt gggaataatt atgtatcctg gtaccagcag ctcccaggaa      660

cagtccccaa actcctcatc tatggtcaca ccaatcggcc cgcaggggtc cctgaccgat      720

tctctggctc caagtctggc acctcagcct ccctggccat cagtgggttc cggtccgagg      780

atgaggctga ttattactgt gcagcatggg atgacagcct gagtggttgg gtgttcggcg      840

gagggaccaa gctgaccgtc ctaggtacgc gtcacaggca gcccagaggc tgggagcaat      900

tgtacaacac tgtgtcattt aaccttggag aagcttatga gtaccccact tttatacaag      960

atttgcgcaa tgaattggct aagggcacac cagtatgtca acttccagtg acactacaaa     1020

ccatagccga tgacaagcga tttgttctag ttgatatcac tacgacctcg aagaaaacag     1080

ttaaggttgc tatagatgtg acagatgtgt atgttgtggg ttatcaagac aaatgggatg     1140

gcaaagatcg agctgttttc cttgacaagg ttcctactgt tgcaactagt aaacttttcc     1200

caggggtgac taatcgtgta acgttaacat ttgatggcag ctatcagaaa cttgtgaatg     1260

ctgccaaagc tgatagaaag gctctcgaac tgggggttaa caaattggaa ttttccattg     1320

aagcaatcca tggtaaaacg ataaatggtc aagaggcagc caagttcttt cttattgtca     1380

tccaaatggt ttcagaggca gctcggttca aatatattga gactgaggtg gttgatagag     1440

gattatatgg atcattcaaa cctaatttta aagtattgaa cttggagaac aactggggcg     1500

acatctctga tgccattcac aaatcatccc cacaatgtac cactattaat ccggcacttc     1560

agttgataag cccctcaaat gacccatggg ttgtaaataa agtgagtcaa attagtcccg     1620

atatgggtat ccttaagttt aaaagctcca aacatcacca ccaccaccat tagtgactcg     1680

ag                                                                    1682


<210>  27
<211>  535
<212>  PRT
<213>  artificial

<220>
<223>  PelB-AvP07-17-(VH-VL-C6.5)-F-deBouganin-His AA

<400>  27

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        35                  40                  45              


Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
65                  70                  75                  80  


Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys Ser Ser 
        115                 120                 125             


Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln His Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
145                 150                 155                 160 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
            180                 185                 190         


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
        195                 200                 205             


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    210                 215                 220                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
225                 230                 235                 240 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Arg His Arg Gln 
            260                 265                 270         


Pro Arg Gly Trp Glu Gln Leu Tyr Asn Thr Val Ser Phe Asn Leu Gly 
        275                 280                 285             


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
    290                 295                 300                 


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
305                 310                 315                 320 


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
                325                 330                 335     


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
            340                 345                 350         


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
        355                 360                 365             


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
    370                 375                 380                 


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
385                 390                 395                 400 


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
                405                 410                 415     


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
            420                 425                 430         


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
        435                 440                 445             


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
    450                 455                 460                 


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
465                 470                 475                 480 


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
                485                 490                 495     


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
            500                 505                 510         


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
        515                 520                 525             


Lys His His His His His His 
    530                 535 


<210>  28
<211>  1664
<212>  DNA
<213>  artificial

<220>
<223>  PelB-AvP07-17-(VH-VL-C6.5)-F-deBouganin NT

<400>  28
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gcaggtgcag ctggtgcagt ctggggcaga ggtgaaaaag cccggggagt      180

ctctgaagat ctcctgtaag ggttctggat acagctttac cagctactgg atcgcctggg      240

tgcgccagat gcccgggaaa ggcctggagt acatggggct catctatcct ggtgactctg      300

acaccaaata cagcccgtcc ttccaaggcc aggtcaccat ctcagtcgac aagtccgtca      360

gcactgccta cttgcaatgg agcagtctga agccctcgga cagcgccgtg tatttttgtg      420

cgagacatga cgtgggatat tgcagtagtt ccaactgcgc aaagtggcct gaatacttcc      480

agcattgggg ccagggcacc ctggtcaccg tttcctcagg tggaggcggt tcacagtctg      540

tgttgacgca gccgccctca gtgtctgcgg ccccaggaca gaaggtcacc atctcctgct      600

ctggaagcag ctccaacatt gggaataatt atgtatcctg gtaccagcag ctcccaggaa      660

cagtccccaa actcctcatc tatggtcaca ccaatcggcc cgcaggggtc cctgaccgat      720

tctctggctc caagtctggc acctcagcct ccctggccat cagtgggttc cggtccgagg      780

atgaggctga ttattactgt gcagcatggg atgacagcct gagtggttgg gtgttcggcg      840

gagggaccaa gctgaccgtc ctaggtacgc gtcacaggca gcccagaggc tgggagcaat      900

tgtacaacac tgtgtcattt aaccttggag aagcttatga gtaccccact tttatacaag      960

atttgcgcaa tgaattggct aagggcacac cagtatgtca acttccagtg acactacaaa     1020

ccatagccga tgacaagcga tttgttctag ttgatatcac tacgacctcg aagaaaacag     1080

ttaaggttgc tatagatgtg acagatgtgt atgttgtggg ttatcaagac aaatgggatg     1140

gcaaagatcg agctgttttc cttgacaagg ttcctactgt tgcaactagt aaacttttcc     1200

caggggtgac taatcgtgta acgttaacat ttgatggcag ctatcagaaa cttgtgaatg     1260

ctgccaaagc tgatagaaag gctctcgaac tgggggttaa caaattggaa ttttccattg     1320

aagcaatcca tggtaaaacg ataaatggtc aagaggcagc caagttcttt cttattgtca     1380

tccaaatggt ttcagaggca gctcggttca aatatattga gactgaggtg gttgatagag     1440

gattatatgg atcattcaaa cctaatttta aagtattgaa cttggagaac aactggggcg     1500

acatctctga tgccattcac aaatcatccc cacaatgtac cactattaat ccggcacttc     1560

agttgataag cccctcaaat gacccatggg ttgtaaataa agtgagtcaa attagtcccg     1620

atatgggtat ccttaagttt aaaagctcca aatagtgact cgag                      1664


<210>  29
<211>  529
<212>  PRT
<213>  artificial

<220>
<223>  PelB-AvP07-17-(VH-VL-C6.5)-F-deBouganin AA

<400>  29

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        35                  40                  45              


Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
65                  70                  75                  80  


Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp 
            100                 105                 110         


Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys Ser Ser 
        115                 120                 125             


Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln His Trp Gly Gln Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
145                 150                 155                 160 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                165                 170                 175     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
            180                 185                 190         


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
        195                 200                 205             


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    210                 215                 220                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
225                 230                 235                 240 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Arg His Arg Gln 
            260                 265                 270         


Pro Arg Gly Trp Glu Gln Leu Tyr Asn Thr Val Ser Phe Asn Leu Gly 
        275                 280                 285             


Glu Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu 
    290                 295                 300                 


Ala Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile 
305                 310                 315                 320 


Ala Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys 
                325                 330                 335     


Lys Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly 
            340                 345                 350         


Tyr Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys 
        355                 360                 365             


Val Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg 
    370                 375                 380                 


Val Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala 
385                 390                 395                 400 


Lys Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe 
                405                 410                 415     


Ser Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala 
            420                 425                 430         


Lys Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe 
        435                 440                 445             


Lys Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe 
    450                 455                 460                 


Lys Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile 
465                 470                 475                 480 


Ser Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro 
                485                 490                 495     


Ala Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys 
            500                 505                 510         


Val Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser 
        515                 520                 525             


Lys 
    


<210>  30
<211>  1664
<212>  DNA
<213>  artificial

<220>
<223>  PelB-deBouganin-F-VL-VH-C6.5 NT

<400>  30
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaattgcag tctgtgttga cgcagccgcc ctcagtgtct gcggccccag      960

gacagaaggt caccatctcc tgctctggaa gcagctccaa cattgggaat aattatgtat     1020

cctggtacca gcagctccca ggaacagtcc ccaaactcct catctatggt cacaccaatc     1080

ggcccgcagg ggtccctgac cgattctctg gctccaagtc tggcacctca gcctccctgg     1140

ccatcagtgg gttccggtcc gaggatgagg ctgattatta ctgtgcagca tgggatgaca     1200

gcctgagtgg ttgggtgttc ggcggaggga ccaagctgac cgtcctaggt ggtggaggcg     1260

gttcacaggt gcagctggtg cagtctgggg cagaggtgaa aaagcccggg gagtctctga     1320

agatctcctg taagggttct ggatacagct ttaccagcta ctggatcgcc tgggtgcgcc     1380

agatgcccgg gaaaggcctg gagtacatgg ggctcatcta tcctggtgac tctgacacca     1440

aatacagccc gtccttccaa ggccaggtca ccatctcagt cgacaagtcc gtcagcactg     1500

cctacttgca atggagcagt ctgaagccct cggacagcgc cgtgtatttt tgtgcgagac     1560

atgacgtggg atattgcagt agttccaact gcgcaaagtg gcctgaatac ttccagcatt     1620

ggggccaggg caccctggtc accgtttcct catagtgact cgag                      1664


<210>  31
<211>  529
<212>  PRT
<213>  artificial

<220>
<223>  PelB-deBouganin-F-VL-VH-C6.5 AA

<400>  31

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu 
            20                  25                  30          


Ala Tyr Glu Tyr Pro Thr Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala 
        35                  40                  45              


Lys Gly Thr Pro Val Cys Gln Leu Pro Val Thr Leu Gln Thr Ile Ala 
    50                  55                  60                  


Asp Asp Lys Arg Phe Val Leu Val Asp Ile Thr Thr Thr Ser Lys Lys 
65                  70                  75                  80  


Thr Val Lys Val Ala Ile Asp Val Thr Asp Val Tyr Val Val Gly Tyr 
                85                  90                  95      


Gln Asp Lys Trp Asp Gly Lys Asp Arg Ala Val Phe Leu Asp Lys Val 
            100                 105                 110         


Pro Thr Val Ala Thr Ser Lys Leu Phe Pro Gly Val Thr Asn Arg Val 
        115                 120                 125             


Thr Leu Thr Phe Asp Gly Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys 
    130                 135                 140                 


Ala Asp Arg Lys Ala Leu Glu Leu Gly Val Asn Lys Leu Glu Phe Ser 
145                 150                 155                 160 


Ile Glu Ala Ile His Gly Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys 
                165                 170                 175     


Phe Phe Leu Ile Val Ile Gln Met Val Ser Glu Ala Ala Arg Phe Lys 
            180                 185                 190         


Tyr Ile Glu Thr Glu Val Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys 
        195                 200                 205             


Pro Asn Phe Lys Val Leu Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser 
    210                 215                 220                 


Asp Ala Ile His Lys Ser Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala 
225                 230                 235                 240 


Leu Gln Leu Ile Ser Pro Ser Asn Asp Pro Trp Val Val Asn Lys Val 
                245                 250                 255     


Ser Gln Ile Ser Pro Asp Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Gln Ser Val Leu 
        275                 280                 285             


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
    290                 295                 300                 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
305                 310                 315                 320 


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
                325                 330                 335     


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
            340                 345                 350         


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
        355                 360                 365             


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
    370                 375                 380                 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
                405                 410                 415     


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            420                 425                 430         


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met 
        435                 440                 445             


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe 
    450                 455                 460                 


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Val Ser Thr Ala Tyr 
465                 470                 475                 480 


Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp Ser Ala Val Tyr Phe Cys 
                485                 490                 495     


Ala Arg His Asp Val Gly Tyr Cys Ser Ser Ser Asn Cys Ala Lys Trp 
            500                 505                 510         


Pro Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        515                 520                 525             


Ser 
    


<210>  32
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Furin linker-H amino acid sequence

<400>  32

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln His 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Furin linker-K amino acid sequence

<400>  33

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Lys 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Furin linker-N amino acid sequence

<400>  34

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Asn 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Furin linker-P amino acid sequence

<400>  35

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Pro 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Furin linker-S amino acid sequence

<400>  36

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Ser 
1               5                   10          


<210>  37
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-WT nucleotide sequence

<400>  37
acccgtcacc gtcagccgcg tggttgggaa cagctg                                 36


<210>  38
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-H nucleotide sequence

<400>  38
acccgtcacc gtcagccgcg tggttgggaa cagcac                                 36


<210>  39
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-K nucleotide sequence

<400>  39
acccgtcacc gtcagccgcg tggttgggaa cagaaa                                 36


<210>  40
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-N nucleotide sequence

<400>  40
acccgtcacc gtcagccgcg tggttgggaa cagaac                                 36


<210>  41
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-P nucleotide sequence

<400>  41
acccgtcacc gtcagccgcg tggttgggaa cagccg                                 36


<210>  42
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-S nucleotide sequence

<400>  42
acccgtcacc gtcagccgcg tggttgggaa cagtct                                 36


<210>  43
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-H modified nucleotide sequence

<400>  43
acgcgtcaca ggcagcccag aggctgggag caacac                                 36


<210>  44
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-K modified nucleotide sequence

<400>  44
acgcgtcaca ggcagcccag aggctgggag caaaaa                                 36


<210>  45
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-N modified nucleotide sequence

<400>  45
acgcgtcaca ggcagcccag aggctgggag caaaac                                 36


<210>  46
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-P modified nucleotide sequence

<400>  46
acgcgtcaca ggcagcccag aggctgggag caaccg                                 36


<210>  47
<211>  36
<212>  DNA
<213>  artificial

<220>
<223>  Furin linker-S modified nucleotide sequence

<400>  47
acgcgtcaca ggcagcccag aggctgggag caatct                                 36


<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin 2 AA

<400>  58

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val His Ser Ala Glu Val Asp Arg Lys Asp Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ile Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu His Gly Ser Phe Lys Pro Asp Phe Lys Val Leu 
            180                 185                 190         


Asp Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  59
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin 3 AA

<400>  59

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val His Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  60
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin 4 AA

<400>  60

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val His Ala Ala Lys Val Asp Arg Lys Asp Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ile Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  61
<211>  250
<212>  PRT
<213>  artificial

<220>
<223>  modified bouganin protein


<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  Xaa may be Thr or Ala or Gln

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  Xaa may be Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (129)..(129)
<223>  Xaa may be Gln or Gly or Glu

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  Xaa may be Asn or Asp or Thr or Ala or Arg or Gln or Glu or Gly 
       or His or Lys or Ser

<220>
<221>  MISC_FEATURE
<222>  (152)..(152)
<223>  Xaa may be Gln or Ala

<400>  61

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Xaa Asp Arg Lys Xaa Leu 
        115                 120                 125             


Xaa Leu Gly Val Xaa Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Xaa Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys 
                245                 250 


<210>  62
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Furin linker-E amino acid sequence

<400>  62

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Glu 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Furin linker-T amino acid sequence

<400>  63

Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Thr 
1               5                   10          


<210>  64
<211>  513
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin-F(E)-AvP07-17-His, aa seq

<400>  64

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys Thr Arg His Arg Gln Pro 
                245                 250                 255     


Arg Gly Trp Glu Gln Glu Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        275                 280                 285             


Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
305                 310                 315                 320 


Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val Asp Lys 
                325                 330                 335     


Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp 
            340                 345                 350         


Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys Ser Ser 
        355                 360                 365             


Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln His Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
385                 390                 395                 400 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                405                 410                 415     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
            420                 425                 430         


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
        435                 440                 445             


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    450                 455                 460                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
465                 470                 475                 480 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly His His His His His 
            500                 505                 510         


His 
    


<210>  65
<211>  1685
<212>  DNA
<213>  artificial

<220>
<223>  PelB- deBouganin-F(E)-AvP07-17-His, nucleotide seq

<400>  65
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaagaacag gtgcagctgg tgcagtctgg ggcagaggtg aaaaagcccg      960

gggagtctct gaagatctcc tgtaagggtt ctggatacag ctttaccagc tactggatcg     1020

cctgggtgcg ccagatgccc gggaaaggcc tggagtacat ggggctcatc tatcctggtg     1080

actctgacac caaatacagc ccgtccttcc aaggccaggt caccatctca gtcgacaagt     1140

ccgtcagcac tgcctacttg caatggagca gtctgaagcc ctcggacagc gccgtgtatt     1200

tttgtgcgag acatgacgtg ggatattgca gtagttccaa ctgcgcaaag tggcctgaat     1260

acttccagca ttggggccag ggcaccctgg tcaccgtttc ctcaggtgga ggcggttcac     1320

agtctgtgtt gacgcagccg ccctcagtgt ctgcggcccc aggacagaag gtcaccatct     1380

cctgctctgg aagcagctcc aacattggga ataattatgt atcctggtac cagcagctcc     1440

caggaacagt ccccaaactc ctcatctatg gtcacaccaa tcggcccgca ggggtccctg     1500

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggttccggt     1560

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttgggtgt     1620

tcggcggagg gaccaagctg accgtcctag gtcatcacca ccaccaccat tagtgactcg     1680

agcgc                                                                 1685


<210>  66
<211>  513
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin-F(T)-AvP07-17-His, aa seq

<400>  66

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys Thr Arg His Arg Gln Pro 
                245                 250                 255     


Arg Gly Trp Glu Gln Thr Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        275                 280                 285             


Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
305                 310                 315                 320 


Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val Asp Lys 
                325                 330                 335     


Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp 
            340                 345                 350         


Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys Ser Ser 
        355                 360                 365             


Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln His Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
385                 390                 395                 400 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                405                 410                 415     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
            420                 425                 430         


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
        435                 440                 445             


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    450                 455                 460                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
465                 470                 475                 480 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly His His His His His 
            500                 505                 510         


His 
    


<210>  67
<211>  1685
<212>  DNA
<213>  artificial

<220>
<223>  PelB- deBouganin-F(T)-AvP07-17-His, nucleotide seq

<400>  67
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaaacccag gtgcagctgg tgcagtctgg ggcagaggtg aaaaagcccg      960

gggagtctct gaagatctcc tgtaagggtt ctggatacag ctttaccagc tactggatcg     1020

cctgggtgcg ccagatgccc gggaaaggcc tggagtacat ggggctcatc tatcctggtg     1080

actctgacac caaatacagc ccgtccttcc aaggccaggt caccatctca gtcgacaagt     1140

ccgtcagcac tgcctacttg caatggagca gtctgaagcc ctcggacagc gccgtgtatt     1200

tttgtgcgag acatgacgtg ggatattgca gtagttccaa ctgcgcaaag tggcctgaat     1260

acttccagca ttggggccag ggcaccctgg tcaccgtttc ctcaggtgga ggcggttcac     1320

agtctgtgtt gacgcagccg ccctcagtgt ctgcggcccc aggacagaag gtcaccatct     1380

cctgctctgg aagcagctcc aacattggga ataattatgt atcctggtac cagcagctcc     1440

caggaacagt ccccaaactc ctcatctatg gtcacaccaa tcggcccgca ggggtccctg     1500

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggttccggt     1560

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttgggtgt     1620

tcggcggagg gaccaagctg accgtcctag gtcatcacca ccaccaccat tagtgactcg     1680

agcgc                                                                 1685


<210>  68
<211>  513
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin-F(P)-AvP07-17-His, aa seq

<400>  68

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys Thr Arg His Arg Gln Pro 
                245                 250                 255     


Arg Gly Trp Glu Gln Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        275                 280                 285             


Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
305                 310                 315                 320 


Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val Asp Lys 
                325                 330                 335     


Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp 
            340                 345                 350         


Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys Ser Ser 
        355                 360                 365             


Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln His Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
385                 390                 395                 400 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                405                 410                 415     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
            420                 425                 430         


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
        435                 440                 445             


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    450                 455                 460                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
465                 470                 475                 480 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly His His His His His 
            500                 505                 510         


His 
    


<210>  69
<211>  1685
<212>  DNA
<213>  artificial

<220>
<223>  PelB- deBouganin-F(P)-AvP07-17-His, nucleotide seq

<400>  69
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaaccgcag gtgcagctgg tgcagtctgg ggcagaggtg aaaaagcccg      960

gggagtctct gaagatctcc tgtaagggtt ctggatacag ctttaccagc tactggatcg     1020

cctgggtgcg ccagatgccc gggaaaggcc tggagtacat ggggctcatc tatcctggtg     1080

actctgacac caaatacagc ccgtccttcc aaggccaggt caccatctca gtcgacaagt     1140

ccgtcagcac tgcctacttg caatggagca gtctgaagcc ctcggacagc gccgtgtatt     1200

tttgtgcgag acatgacgtg ggatattgca gtagttccaa ctgcgcaaag tggcctgaat     1260

acttccagca ttggggccag ggcaccctgg tcaccgtttc ctcaggtgga ggcggttcac     1320

agtctgtgtt gacgcagccg ccctcagtgt ctgcggcccc aggacagaag gtcaccatct     1380

cctgctctgg aagcagctcc aacattggga ataattatgt atcctggtac cagcagctcc     1440

caggaacagt ccccaaactc ctcatctatg gtcacaccaa tcggcccgca ggggtccctg     1500

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggttccggt     1560

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttgggtgt     1620

tcggcggagg gaccaagctg accgtcctag gtcatcacca ccaccaccat tagtgactcg     1680

agcgc                                                                 1685


<210>  70
<211>  507
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin-F(E)-AvP07-17, aa seq

<400>  70

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys Thr Arg His Arg Gln Pro 
                245                 250                 255     


Arg Gly Trp Glu Gln Glu Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        275                 280                 285             


Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
305                 310                 315                 320 


Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val Asp Lys 
                325                 330                 335     


Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp 
            340                 345                 350         


Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys Ser Ser 
        355                 360                 365             


Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln His Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
385                 390                 395                 400 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                405                 410                 415     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
            420                 425                 430         


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
        435                 440                 445             


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    450                 455                 460                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
465                 470                 475                 480 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505         


<210>  71
<211>  1667
<212>  DNA
<213>  artificial

<220>
<223>  PelB- deBouganin-F(E)-AvP07-17, nucleotide seq

<400>  71
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaagaacag gtgcagctgg tgcagtctgg ggcagaggtg aaaaagcccg      960

gggagtctct gaagatctcc tgtaagggtt ctggatacag ctttaccagc tactggatcg     1020

cctgggtgcg ccagatgccc gggaaaggcc tggagtacat ggggctcatc tatcctggtg     1080

actctgacac caaatacagc ccgtccttcc aaggccaggt caccatctca gtcgacaagt     1140

ccgtcagcac tgcctacttg caatggagca gtctgaagcc ctcggacagc gccgtgtatt     1200

tttgtgcgag acatgacgtg ggatattgca gtagttccaa ctgcgcaaag tggcctgaat     1260

acttccagca ttggggccag ggcaccctgg tcaccgtttc ctcaggtgga ggcggttcac     1320

agtctgtgtt gacgcagccg ccctcagtgt ctgcggcccc aggacagaag gtcaccatct     1380

cctgctctgg aagcagctcc aacattggga ataattatgt atcctggtac cagcagctcc     1440

caggaacagt ccccaaactc ctcatctatg gtcacaccaa tcggcccgca ggggtccctg     1500

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggttccggt     1560

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttgggtgt     1620

tcggcggagg gaccaagctg accgtcctag gttagtgact cgagcgc                   1667


<210>  72
<211>  507
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin-F(T)-AvP07-17, aa seq

<400>  72

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys Thr Arg His Arg Gln Pro 
                245                 250                 255     


Arg Gly Trp Glu Gln Thr Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        275                 280                 285             


Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
305                 310                 315                 320 


Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val Asp Lys 
                325                 330                 335     


Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp 
            340                 345                 350         


Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys Ser Ser 
        355                 360                 365             


Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln His Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
385                 390                 395                 400 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                405                 410                 415     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
            420                 425                 430         


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
        435                 440                 445             


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    450                 455                 460                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
465                 470                 475                 480 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505         


<210>  73
<211>  1667
<212>  DNA
<213>  artificial

<220>
<223>  PelB- deBouganin-F(T)-AvP07-17, nucleotide seq

<400>  73
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaaacccag gtgcagctgg tgcagtctgg ggcagaggtg aaaaagcccg      960

gggagtctct gaagatctcc tgtaagggtt ctggatacag ctttaccagc tactggatcg     1020

cctgggtgcg ccagatgccc gggaaaggcc tggagtacat ggggctcatc tatcctggtg     1080

actctgacac caaatacagc ccgtccttcc aaggccaggt caccatctca gtcgacaagt     1140

ccgtcagcac tgcctacttg caatggagca gtctgaagcc ctcggacagc gccgtgtatt     1200

tttgtgcgag acatgacgtg ggatattgca gtagttccaa ctgcgcaaag tggcctgaat     1260

acttccagca ttggggccag ggcaccctgg tcaccgtttc ctcaggtgga ggcggttcac     1320

agtctgtgtt gacgcagccg ccctcagtgt ctgcggcccc aggacagaag gtcaccatct     1380

cctgctctgg aagcagctcc aacattggga ataattatgt atcctggtac cagcagctcc     1440

caggaacagt ccccaaactc ctcatctatg gtcacaccaa tcggcccgca ggggtccctg     1500

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggttccggt     1560

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttgggtgt     1620

tcggcggagg gaccaagctg accgtcctag gttagtgact cgagcgc                   1667


<210>  74
<211>  507
<212>  PRT
<213>  artificial

<220>
<223>  deBouganin-F(P)-AvP07-17, aa seq

<400>  74

Tyr Asn Thr Val Ser Phe Asn Leu Gly Glu Ala Tyr Glu Tyr Pro Thr 
1               5                   10                  15      


Phe Ile Gln Asp Leu Arg Asn Glu Leu Ala Lys Gly Thr Pro Val Cys 
            20                  25                  30          


Gln Leu Pro Val Thr Leu Gln Thr Ile Ala Asp Asp Lys Arg Phe Val 
        35                  40                  45              


Leu Val Asp Ile Thr Thr Thr Ser Lys Lys Thr Val Lys Val Ala Ile 
    50                  55                  60                  


Asp Val Thr Asp Val Tyr Val Val Gly Tyr Gln Asp Lys Trp Asp Gly 
65                  70                  75                  80  


Lys Asp Arg Ala Val Phe Leu Asp Lys Val Pro Thr Val Ala Thr Ser 
                85                  90                  95      


Lys Leu Phe Pro Gly Val Thr Asn Arg Val Thr Leu Thr Phe Asp Gly 
            100                 105                 110         


Ser Tyr Gln Lys Leu Val Asn Ala Ala Lys Ala Asp Arg Lys Ala Leu 
        115                 120                 125             


Glu Leu Gly Val Asn Lys Leu Glu Phe Ser Ile Glu Ala Ile His Gly 
    130                 135                 140                 


Lys Thr Ile Asn Gly Gln Glu Ala Ala Lys Phe Phe Leu Ile Val Ile 
145                 150                 155                 160 


Gln Met Val Ser Glu Ala Ala Arg Phe Lys Tyr Ile Glu Thr Glu Val 
                165                 170                 175     


Val Asp Arg Gly Leu Tyr Gly Ser Phe Lys Pro Asn Phe Lys Val Leu 
            180                 185                 190         


Asn Leu Glu Asn Asn Trp Gly Asp Ile Ser Asp Ala Ile His Lys Ser 
        195                 200                 205             


Ser Pro Gln Cys Thr Thr Ile Asn Pro Ala Leu Gln Leu Ile Ser Pro 
    210                 215                 220                 


Ser Asn Asp Pro Trp Val Val Asn Lys Val Ser Gln Ile Ser Pro Asp 
225                 230                 235                 240 


Met Gly Ile Leu Lys Phe Lys Ser Ser Lys Thr Arg His Arg Gln Pro 
                245                 250                 255     


Arg Gly Trp Glu Gln Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            260                 265                 270         


Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly 
        275                 280                 285             


Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr 
305                 310                 315                 320 


Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val Asp Lys 
                325                 330                 335     


Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp 
            340                 345                 350         


Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys Ser Ser 
        355                 360                 365             


Ser Asn Cys Ala Lys Trp Pro Glu Tyr Phe Gln His Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
385                 390                 395                 400 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
                405                 410                 415     


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
            420                 425                 430         


Tyr Gln Gln Leu Pro Gly Thr Val Pro Lys Leu Leu Ile Tyr Gly His 
        435                 440                 445             


Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    450                 455                 460                 


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg Ser Glu Asp Glu 
465                 470                 475                 480 


Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505         


<210>  75
<211>  1667
<212>  DNA
<213>  artificial

<220>
<223>  PelB- deBouganin-F(P)-AvP07-17, nucleotide seq

<400>  75
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcataatgaa atacctattg cctacggcag ccgctggatt gttattactc gctgcccaac      120

cagcgatggc gtacaacact gtgtcattta accttggaga agcttatgag taccccactt      180

ttatacaaga tttgcgcaat gaattggcta agggcacacc agtatgtcaa cttccagtga      240

cactacaaac catagccgat gacaagcgat ttgttctagt tgatatcact acgacctcga      300

agaaaacagt taaggttgct atagatgtga cagatgtgta tgttgtgggt tatcaagaca      360

aatgggatgg caaagatcga gctgttttcc ttgacaaggt tcctactgtt gcaactagta      420

aacttttccc aggggtgact aatcgtgtaa cgttaacatt tgatggcagc tatcagaaac      480

ttgtgaatgc tgccaaagct gatagaaagg ctctcgaact gggggttaac aaattggaat      540

tttccattga agcaatccat ggtaaaacga taaatggtca agaggcagcc aagttctttc      600

ttattgtcat ccaaatggtt tcagaggcag ctcggttcaa atatattgag actgaggtgg      660

ttgatagagg attatatgga tcattcaaac ctaattttaa agtattgaac ttggagaaca      720

actggggcga catctctgat gccattcaca aatcatcccc acaatgtacc actattaatc      780

cggcacttca gttgataagc ccctcaaatg acccatgggt tgtaaataaa gtgagtcaaa      840

ttagtcccga tatgggtatc cttaagttta aaagctccaa aacgcgtcac aggcagccca      900

gaggctggga gcaaccgcag gtgcagctgg tgcagtctgg ggcagaggtg aaaaagcccg      960

gggagtctct gaagatctcc tgtaagggtt ctggatacag ctttaccagc tactggatcg     1020

cctgggtgcg ccagatgccc gggaaaggcc tggagtacat ggggctcatc tatcctggtg     1080

actctgacac caaatacagc ccgtccttcc aaggccaggt caccatctca gtcgacaagt     1140

ccgtcagcac tgcctacttg caatggagca gtctgaagcc ctcggacagc gccgtgtatt     1200

tttgtgcgag acatgacgtg ggatattgca gtagttccaa ctgcgcaaag tggcctgaat     1260

acttccagca ttggggccag ggcaccctgg tcaccgtttc ctcaggtgga ggcggttcac     1320

agtctgtgtt gacgcagccg ccctcagtgt ctgcggcccc aggacagaag gtcaccatct     1380

cctgctctgg aagcagctcc aacattggga ataattatgt atcctggtac cagcagctcc     1440

caggaacagt ccccaaactc ctcatctatg gtcacaccaa tcggcccgca ggggtccctg     1500

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggttccggt     1560

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttgggtgt     1620

tcggcggagg gaccaagctg accgtcctag gttagtgact cgagcgc                   1667


