                         SEQUENCE LISTING

<110>  University of Pittsburgh
 
<120>  Method to Improve Neurologic Outcomes in Temperature Managed 
       Patients

<130>  6527-1601787

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Glu Glu Gly Lys Leu Phe Val Gly Gly Leu Asn Phe Asn 
1               5                   10                  15      


Thr Asp Glu Gln Ala Leu Glu Asp His Phe Ser Ser Phe Gly Pro Ile 
            20                  25                  30          


Ser Glu Val Val Val Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly 
        35                  40                  45              


Phe Gly Phe Ile Thr Phe Thr Asn Pro Glu His Ala Ser Val Ala Met 
    50                  55                  60                  


Arg Ala Met Asn Gly Glu Ser Leu Asp Gly Arg Gln Ile Arg Val Asp 
65                  70                  75                  80  


His Ala Gly Lys Ser Ala Arg Gly Thr Arg Gly Gly Gly Phe Gly Ala 
                85                  90                  95      


His Gly Arg Gly Arg Ser Tyr Ser Arg Gly Gly Gly Asp Gln Gly Tyr 
            100                 105                 110         


Gly Ser Gly Arg Tyr Tyr Asp Ser Arg Pro Gly Gly Tyr Gly Tyr Gly 
        115                 120                 125             


Tyr Gly Arg Ser Arg Asp Tyr Asn Gly Arg Asn Gln Gly Gly Tyr Asp 
    130                 135                 140                 


Arg Tyr Ser Gly Gly Asn Tyr Arg Asp Asn Tyr Asp Asn 
145                 150                 155         


<210>  2
<211>  4432
<212>  DNA
<213>  Homo sapiens

<400>  2
gaacactgct cccttcgctt tgctgtccct tcctctcccc accactccgc tcctgctggc       60

ctcagccaat cagcacgcac gccgggacgc gcaaggggaa cgttccggga cgttctcgct      120

acgtactctt tatcaatcgt cttccggcgc agccccgtcc ctgttttttg tgctcctccg      180

agctcgctgt tcgtccgggt tttttacgtt ttaatttcca ggacttgaac tgccatgtcc      240

tctgaagaag gaaagctctt cgtgggaggg ctcaacttta acaccgacga gcaggcactg      300

gaagaccact tcagcagttt cggacctatc tctgaggtgg tcgttgtcaa ggaccgggag      360

actcagcggt ccaggggttt tggtttcatc accttcacca acccagagca tgcttcagtt      420

gccatgagag ccatgaacgg agagtctctg gatggtcgtc agatccgtgt ggatcatgca      480

ggcaagtctg ctcggggaac cagaggaggt ggctttgggg cccatgggcg tggtcgcagc      540

tactctagag gtggtgggga ccagggctat gggagtggca ggtattatga cagtcgacct      600

ggagggtatg gatatggata tggacgttcc agagactata atggcagaaa ccagggtggt      660

tatgaccgct actcaggagg aaattacaga gacaattatg acaactgaaa tgagacatgc      720

acataatata gatacacaag gaataatttc tgatccagga tcgtccttcc aaatggctgt      780

atttataaag gtttttggag ctgcaccgaa gcatcttatt ttatagtata tcaacctttt      840

gtttttaaat tgacctgcca aggtagctga agacctttta gacagttcca tctttttttt      900

taaatttttt ctgcctattt aaagacaaat tatgggacgt ttgtagaacc tgagtatttt      960

tctttttacc agttttttag tttgagctct taggtttatt ggagctagca ataattggtt     1020

ctggcaagtt tggccagact gacttcaaaa aattaatgtg tatccaggga cattttaaaa     1080

acctgtacac agtgtttatt gtggttagga agcaatttcc caatgtacct ataagaaatg     1140

tgcatcaagc cagcctgacc aacatggtga aaccccatct gtactaaaca taaaaaaatt     1200

agcctggcat ggtggtgtac gcctgtaatc ccagtgactt gggaggctga ggcaggagaa     1260

tcgcttgaac ccgggaggcg gaggttgcag tgagctaaga tcgcgccact gtactccagc     1320

ctgggcaaca gcgagactcc atctcaaaaa aaaaggaaat gtgtatcaag aacatgatta     1380

tccagcggta ttttctaatt cagatcatca aactgattat atagaagagt tggctttaaa     1440

atgtttgcaa atgtcttttt ttttttaata ctggaagaaa aaatattctg ttgtgtctca     1500

tacagtgctt aggatgtctt tcacagagct tattaaaaag atgaaacctg agaacaaact     1560

gctttattct tactcagccc attttgcaaa ttaaaagtgg gggcagaggt gggcggatca     1620

cctgaggtca ggagttcgag accagcctgg ccaacagggc aaaaccccat ctctactaaa     1680

aatacaaaag ttagcggggc gtggtggcgg gtgcatgtaa tcccagctac tcgggaggct     1740

gaggcaggag aattgcttga acccaggagg cggaagttgc agtgagctga gattgtgcca     1800

ctgcactcca gcctaggtga cagcaagact ctgtctcaaa aaaaaaaaaa tggcacatca     1860

acgagaggga ggcttggaga atatttggtt ggtgggtggg cagggactgc cagagggtta     1920

ggtgtacatt gaggcctgag gcctgctgga attgggtttc cttaactggt ctcttatctt     1980

agtcccattg ttctgagaac ataagcacct aatctcatgg cgtgagctaa tccctatcat     2040

aaatagtggt accagttcat tccttcccct gaaatgatgg gggttgggca gagatgcact     2100

gaactcatct ttgtgtatga gggccatgag agaggcctgg tttgaaaaca atgctaagag     2160

ctcagattcc aggatttatg taggggctct tctacttccc aggtatttga cctcaggtga     2220

gtcatttaat ttcagcctta tgccatttta cattttctgt ggagggttag gttaattggc     2280

atataaagcc actgagaaga gttggcaaag ctctcagtca cggggatttg atcttttttg     2340

gtgtgtgtgt gtcttgggtg gtaaagtggt aattttgtaa ttctagctgg tcttagttcc     2400

tcagttctgc tccctttagt catggttctt tctagtggct gtattgaggc cccatgggtg     2460

ttatccctcc attggttcta gtttggaaca gaaaaatctg ttgtattcat ggctttcacc     2520

tggctaatac tgagctaagt taccaccagg ttgcaaactc caggacatta ttgtcctgag     2580

ctgcctattc ccttgctggt gcgttgtgga accctgtatt attagttcca gtcctggagg     2640

cctgcctcct gagtttccca gctagttggg acaggcccca atatcccttc ttcctgtaac     2700

ccaaacagtc atgaatttgc tttggcaggt ggatggagac ttgggaactt ccacctcacc     2760

cactaagcca ggcccaggct atggggcatt gtggctaacc ccaccaggtg gatacttggt     2820

ctgaggacgc atcttattct gggcctttag ggagctaagg cagtgagaat tggcaggagg     2880

actgctgtga atgccttgta ggtcggggga ttggaggggg tcctctgctc cctgtctctc     2940

aggatggcaa tgtacctctc acccccagtg tcagctgagg taggatccat aatcagtaat     3000

attcctgcaa caaaatgttc ctaagtggaa tcaatgaaga ccaaaattta tttgtataac     3060

aactctaaac ctgctctgct ctgctgtgtt tacaatgtgc tttgtgatca tccagcccag     3120

ggagtcccag tctctggctg tctatctgct ctaaggaaga gagcccacag ttctctatag     3180

tgccatagtc tgtgatgaat aaagttccag atttgaggtc aacccccgac cacccttaaa     3240

gtgcttgttg gtctcctact ttggtttgtc ttcagcatcc aactgatgca catttgtcaa     3300

gaacccactg aggctagaaa ccccccaaac actcaaggta ccttgagaac atgtatccca     3360

agacctgcaa agaccaaaca catggcctgt aactactttt cactttcaag ccctggaact     3420

tgtctgtacc aaaaatcttt ctgaaccatt caccaaatct cttgtcaagg gccagaataa     3480

attaagagat tggcttttgg ttttcaatta ggctttcaag tcctaagccc aacccctcct     3540

atcccaccta ggcagaaatc acttcagatc cttgcttcct agtttaattt cttctctgcc     3600

tcagttataa catccataaa atggaaataa taatacccac ctcacacagg ggttaggagt     3660

gtttttttgt tggttttttt ccagacaggg tctcactctg tctcccaggc tggagtgcag     3720

tggcacaatc tcggctcact gtaccctccg cctcccaggt tcaagcagtt ctcatgcctc     3780

agcctcccaa gtagctggga ttacaggtgc ctgccaccac gcccggctaa tttttgtatt     3840

aatagagaca gggtttcacc gtgttgggca ggctggtcct gaactcctga cctcaagtga     3900

tccacccgcc tcggcctccc aaagtgctgg gattacaggc gtgagccacc acacctggcc     3960

taggagttaa gagtattaaa tgttaagaac agaccaagtc catcaaacag ctccacaccc     4020

ttgttccatg ttctggattg gggagttgtg ggggtggagg tgtagaactt ttaaaaagct     4080

tcttaaaata agttgctgtg aatacttcag gtatataaaa aaacattggt tgacaataag     4140

ccagtgttct gccattctta cctgcttatc aagacaaaac ctgctcaagt ccctgcccag     4200

ctgcattcca agtgttttca agtttggtgg taagacctga cctgaggctt cttataacct     4260

ttactcagtg ggaatatgca tacagttcac tacagaaata tttgtattta cttagaggaa     4320

gtgccctgga tctgggggcg ggggggggcg gggggaatgg gtcttttcta aattgttaaa     4380

agcagttcat gccattattc ttaataaaca tttctaatat gctgtgaaag ag             4432


<210>  3
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  3

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  4
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  4

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  5
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  6
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
1               5                   10                  15      


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
            20                  25                  30          


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
        35                  40                  45              


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
    50                  55                  60                  


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
65                  70                  75                  80  


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
                85                  90                  95      


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
            100                 105                 110         


His Cys Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
        115                 120                 125             


Pro Cys Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
    130                 135                 140                 


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
145                 150                 155                 160 


Pro Leu Ala Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
                165                 170                 175     


Ser 
    


