                         SEQUENCE LISTING

<110>  LAWMAN, MICHAEL J. P.
       LAWMAN, PATRICIA A.
       GENTILINI, MEGHAN
       RAMIYA, VIJAY
       BASTAWROUS, MARINA VICTOR ABDELMASEEH
 
<120>  MULTI-INDICATION mRNA CANCER IMMUNOTHERAPY

<130>  MOR.205XC1PCT

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1854
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Theoretical emm55 mRNA sequence


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5' ARCA methylguanosine cap

<220>
<221>  misc_feature
<222>  (3)..(132)
<223>  5' untranslated region

<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  start codon

<220>
<221>  misc_feature
<222>  (133)..(1804)
<223>  emm55 gene

<220>
<221>  misc_feature
<222>  (1806)..(1854)
<223>  Poly(A) tail, minimum of 50 adenosines

<400>  1
gggagaagau cuuugucgau ccuaccaucc acucgacaca cccgccagcg gccgcugcca       60

agcuuccgag cucaagcuuc gaauucugca gucgacggua ccgcgggccc gggauccaua      120

aggagcauaa aaauggcuaa aaauaccacg aauagacacu auucgcuuag aaaauuaaaa      180

acaggaacgg cuucaguagc aguagcuuug acuguuuuag ggacaggacu gguagcaggg      240

cagacaguaa aagcaagcca aacagaacca ucucagacca auaacagauu auaucaagaa      300

agacaacguu uacaggauuu aaaaaguaag uuucaagacc ugaaaaaucg uucagaggga      360

uacauucagc aauacuacga cgaagaaaag aacaguggaa guaacucuaa cugguacgca      420

accuacuuaa aagaauuaaa ugacgaauuu gaacaagcuu auaaugaacu uaguggugau      480

gguguaaaaa aauuagcugc aaguuugaug gaagaaagag ucgcuuuaag agacgaaauc      540

gaucagauua agaaaauauc agaagaauua aaaaauaagc ugagagcaaa agaagaagaa      600

uuaaaaaaua aaaaagagga acgugagcuu gagcaugcug ccuaugcagc agaugcaaag      660

aaacaugaag aauaugucaa auccaugucu cucguacuaa uggauaaaga agaggagcgu      720

cauaaacuag agcaaucauu agacacggcu aaagcugagc uuguuaaaaa agagcaagag      780

uuacaguuag ucaaaggcaa ucuagaucaa aaagaaaaag aacuagaaaa ugaagagcua      840

gcgaaagaaa gugcuauuag ugauuugacu gagcagauua cugcuaagaa ggcugaagua      900

gaaaaauuaa cucaagauuu agcugcuaag ucugcugaaa uucaggaaaa agaagcugaa      960

aaagaucgcc aacagcauau guacgaagcg uuuaugagcc aguacaaaga aaaaguugag     1020

aaacaagagc aagagcuugc uaagcuaaaa caacuugaaa ccaucaacaa caaucuauua     1080

gguaaugcua aggauaugau agcuaaguug ucugcugaaa augaacaauu agcaagcgac     1140

aaagcaaaac uugaagaaca aaacaagauu ucagaagcga gccguaaagg ucuucgucgu     1200

gacuuggacg caucacguga agcuaagaaa caaguugaaa aagauuuagc aaacuugacu     1260

gcugaacuug auaagguuaa agaagauaaa caaauuucag acgcaagccg uaaaggucuu     1320

cgucgugacu uggacgcauc acgugaagcu aagaaacaag uugaaaaagc uuuagaagaa     1380

gcaaacagca aauuagcggc ucuugaaaaa cuuaacaaag agcuugaaga aagcaagaaa     1440

uuaacagaaa aagaaaaagc ugagcuacaa gcgaaacuug aagcagaagc aaaagcacuc     1500

aaagaacaau uagcgaaaca agcugaagaa cuugcaaaac uaagagcugg aaaagcauca     1560

gacucacaaa ccccugaugc aaaaccagga aacaaaguug uuccagguac aggucaagca     1620

ccacaagcag gcacaaaacc uaaccaaaac aaagcaccaa ugaaggaaac uaagagacag     1680

uuaccaucaa caggugaagc agcuaaucca uucuuuacag cggcagcccu uacuguuaug     1740

gcaacagcug gaguagcagc aguuguaaaa cgcaaagaag aaaacgaagc ugaauucugc     1800

agauaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa           1854


<210>  2
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Emm55 Protein Sequence

<400>  2

Met Ala Lys Asn Thr Thr Asn Arg His Tyr Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      


Thr Gly Thr Ala Ser Val Ala Val Ala Leu Thr Val Leu Gly Thr Gly 
            20                  25                  30          


Leu Val Ala Gly Gln Thr Val Lys Ala Ser Gln Thr Glu Pro Ser Gln 
        35                  40                  45              


Thr Asn Asn Arg Leu Tyr Gln Glu Arg Gln Arg Leu Gln Asp Leu Lys 
    50                  55                  60                  


Ser Lys Phe Gln Asp Leu Lys Asn Arg Ser Glu Gly Tyr Ile Gln Gln 
65                  70                  75                  80  


Tyr Tyr Asp Glu Glu Lys Asn Ser Gly Ser Asn Ser Asn Trp Tyr Ala 
                85                  90                  95      


Thr Tyr Leu Lys Glu Leu Asn Asp Glu Phe Glu Gln Ala Tyr Asn Glu 
            100                 105                 110         


Leu Ser Gly Asp Gly Val Lys Lys Leu Ala Ala Ser Leu Met Glu Glu 
        115                 120                 125             


Arg Val Ala Leu Arg Asp Glu Ile Asp Gln Ile Lys Lys Ile Ser Glu 
    130                 135                 140                 


Glu Leu Lys Asn Lys Leu Arg Ala Lys Glu Glu Glu Leu Lys Asn Lys 
145                 150                 155                 160 


Lys Glu Glu Arg Glu Leu Glu His Ala Ala Tyr Ala Ala Asp Ala Lys 
                165                 170                 175     


Lys His Glu Glu Tyr Val Lys Ser Met Ser Leu Val Leu Met Asp Lys 
            180                 185                 190         


Glu Glu Glu Arg His Lys Leu Glu Gln Ser Leu Asp Thr Ala Lys Ala 
        195                 200                 205             


Glu Leu Val Lys Lys Glu Gln Glu Leu Gln Leu Val Lys Gly Asn Leu 
    210                 215                 220                 


Asp Gln Lys Glu Lys Glu Leu Glu Asn Glu Glu Leu Ala Lys Glu Ser 
225                 230                 235                 240 


Ala Ile Ser Asp Leu Thr Glu Gln Ile Thr Ala Lys Lys Ala Glu Val 
                245                 250                 255     


Glu Lys Leu Thr Gln Asp Leu Ala Ala Lys Ser Ala Glu Ile Gln Glu 
            260                 265                 270         


Lys Glu Ala Glu Lys Asp Arg Gln Gln His Met Tyr Glu Ala Phe Met 
        275                 280                 285             


Ser Gln Tyr Lys Glu Lys Val Glu Lys Gln Glu Gln Glu Leu Ala Lys 
    290                 295                 300                 


Leu Lys Gln Leu Glu Thr Ile Asn Asn Asn Leu Leu Gly Asn Ala Lys 
305                 310                 315                 320 


Asp Met Ile Ala Lys Leu Ser Ala Glu Asn Glu Gln Leu Ala Ser Asp 
                325                 330                 335     


Lys Ala Lys Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser Arg Lys 
            340                 345                 350         


Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val 
        355                 360                 365             


Glu Lys Asp Leu Ala Asn Leu Thr Ala Glu Leu Asp Lys Val Lys Glu 
    370                 375                 380                 


Asp Lys Gln Ile Ser Asp Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu 
385                 390                 395                 400 


Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu 
                405                 410                 415     


Ala Asn Ser Lys Leu Ala Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu 
            420                 425                 430         


Glu Ser Lys Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys 
        435                 440                 445             


Leu Glu Ala Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala Lys Gln Ala 
    450                 455                 460                 


Glu Glu Leu Ala Lys Leu Arg Ala Gly Lys Ala Ser Asp Ser Gln Thr 
465                 470                 475                 480 


Pro Asp Ala Lys Pro Gly Asn Lys Val Val Pro Gly Thr Gly Gln Ala 
                485                 490                 495     


Pro Gln Ala Gly Thr Lys Pro Asn Gln Asn Lys Ala Pro Met Lys Glu 
            500                 505                 510         


Thr Lys Arg Gln Leu Pro Ser Thr Gly Glu Ala Ala Asn Pro Phe Phe 
        515                 520                 525             


Thr Ala Ala Ala Leu Thr Val Met Ala Thr Ala Gly Val Ala Ala Val 
    530                 535                 540                 


Val Lys Arg Lys Glu Glu Asn Glu Ala Glu Phe Cys Arg 
545                 550                 555         


<210>  3
<211>  179
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Theoretical emmL mRNA sequence


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5' ARCA methylguanosine cap

<220>
<221>  misc_feature
<222>  (3)..(132)
<223>  5' untranslated region

<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  start codon

<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  emmL gene

<220>
<221>  misc_feature
<222>  (136)..(179)
<223>  Poly(A) tail, minimum of 50 adenosines

<400>  3
gggagaagau cuuugucgau ccuaccaucc acucgacaca cccgccagcg gccgcugcca       60

agcuuccgag cucaagcuuc gaauucugca gucgacggua ccgcgggccc gggauccaua      120

aggagcauaa aaaugaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa       179


