
                                SEQUENCE LISTING

<110> MORRISON, Karen Jane Meyrick
      

<120> ANTIBODIES THAT BIND TO AXL PROTEINS
  

<130> 511582009840

<140> NOT YET ASSIGNED    
<141>             

<150> 62/163264           
<151> 2015-05-18  

<160> 31

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4743
<212> DNA
<213> Homo sapiens

<400> 1
gggaaggagg caggggtgct gagaaggcgg ctgctgggca gagccggtgg caagggcctc 60
ccctgccgct gtgccaggca ggcagtgcca aatccgggga gcctggagct ggggggaggg 120
ccggggacag cccggccctg ccccctcccc cgctgggagc ccaacaactt ctgaggaaag 180
tttggcaccc atggcgtggc ggtgccccag gatgggcagg gtcccgctgg cctggtgctt 240
ggcgctgtgc ggctgggcgt gcatggcccc caggggcacg caggctgaag aaagtccctt 300
cgtgggcaac ccagggaata tcacaggtgc ccggggactc acgggcaccc ttcggtgtca 360
gctccaggtt cagggagagc cccccgaggt acattggctt cgggatggac agatcctgga 420
gctcgcggac agcacccaga cccaggtgcc cctgggtgag gatgaacagg atgactggat 480
agtggtcagc cagctcagaa tcacctccct gcagctttcc gacacgggac agtaccagtg 540
tttggtgttt ctgggacatc agaccttcgt gtcccagcct ggctatgttg ggctggaggg 600
cttgccttac ttcctggagg agcccgaaga caggactgtg gccgccaaca cccccttcaa 660
cctgagctgc caagctcagg gacccccaga gcccgtggac ctactctggc tccaggatgc 720
tgtccccctg gccacggctc caggtcacgg cccccagcgc agcctgcatg ttccagggct 780
gaacaagaca tcctctttct cctgcgaagc ccataacgcc aagggggtca ccacatcccg 840
cacagccacc atcacagtgc tcccccagca gccccgtaac ctccacctgg tctcccgcca 900
acccacggag ctggaggtgg cttggactcc aggcctgagc ggcatctacc ccctgaccca 960
ctgcaccctg caggctgtgc tgtcagacga tgggatgggc atccaggcgg gagaaccaga 1020
ccccccagag gagcccctca cctcgcaagc atccgtgccc ccccatcagc ttcggctagg 1080
cagcctccat cctcacaccc cttatcacat ccgcgtggca tgcaccagca gccagggccc 1140
ctcatcctgg acccactggc ttcctgtgga gacgccggag ggagtgcccc tgggcccccc 1200
tgagaacatt agtgctacgc ggaatgggag ccaggccttc gtgcattggc aagagccccg 1260
ggcgcccctg cagggtaccc tgttagggta ccggctggcg tatcaaggcc aggacacccc 1320
agaggtgcta atggacatag ggctaaggca agaggtgacc ctggagctgc agggggacgg 1380
gtctgtgtcc aatctgacag tgtgtgtggc agcctacact gctgctgggg atggaccctg 1440
gagcctccca gtacccctgg aggcctggcg cccagggcaa gcacagccag tccaccagct 1500
ggtgaaggaa ccttcaactc ctgccttctc gtggccctgg tggtatgtac tgctaggagc 1560
agtcgtggcc gctgcctgtg tcctcatctt ggctctcttc cttgtccacc ggcgaaagaa 1620
ggagacccgt tatggagaag tgtttgaacc aacagtggaa agaggtgaac tggtagtcag 1680
gtaccgcgtg cgcaagtcct acagtcgtcg gaccactgaa gctaccttga acagcctggg 1740
catcagtgaa gagctgaagg agaagctgcg ggatgtgatg gtggaccggc acaaggtggc 1800
cctggggaag actctgggag agggagagtt tggagctgtg atggaaggcc agctcaacca 1860
ggacgactcc atcctcaagg tggctgtgaa gacgatgaag attgccatct gcacgaggtc 1920
agagctggag gatttcctga gtgaagcggt ctgcatgaag gaatttgacc atcccaacgt 1980
catgaggctc atcggtgtct gtttccaggg ttctgaacga gagagcttcc cagcacctgt 2040
ggtcatctta cctttcatga aacatggaga cctacacagc ttcctcctct attcccggct 2100
cggggaccag ccagtgtacc tgcccactca gatgctagtg aagttcatgg cagacatcgc 2160
cagtggcatg gagtatctga gtaccaagag attcatacac cgggacctgg cggccaggaa 2220
ctgcatgctg aatgagaaca tgtccgtgtg tgtggcggac ttcgggctct ccaagaagat 2280
ctacaatggg gactactacc gccagggacg tatcgccaag atgccagtca agtggattgc 2340
cattgagagt ctagctgacc gtgtctacac cagcaagagc gatgtgtggt ccttcggggt 2400
gacaatgtgg gagattgcca caagaggcca aaccccatat ccgggcgtgg agaacagcga 2460
gatttatgac tatctgcgcc agggaaatcg cctgaagcag cctgcggact gtctggatgg 2520
actgtatgcc ttgatgtcgc ggtgctggga gctaaatccc caggaccggc caagttttac 2580
agagctgcgg gaagatttgg agaacacact gaaggccttg cctcctgccc aggagcctga 2640
cgaaatcctc tatgtcaaca tggatgaggg tggaggttat cctgaacccc ctggagctgc 2700
aggaggagct gaccccccaa cccagccaga ccctaaggat tcctgtagct gcctcactgc 2760
ggctgaggtc catcctgctg gacgctatgt cctctgccct tccacaaccc ctagccccgc 2820
tcagcctgct gataggggct ccccagcagc cccagggcag gaggatggtg cctgagacaa 2880
ccctccacct ggtactccct ctcaggatcc aagctaagca ctgccactgg ggaaaactcc 2940
accttcccac tttcccaccc cacgccttat ccccacttgc agccctgtct tcctacctat 3000
cccacctcca tcccagacag gtccctcccc ttctctgtgc agtagcatca ccttgaaagc 3060
agtagcatca ccatctgtaa aaggaagggg ttggattgca atatctgaag ccctcccagg 3120
tgttaacatt ccaagactct agagtccaag gtttaaagag tctagattca aaggttctag 3180
gtttcaaaga tgctgtgagt ctttggttct aaggacctga aattccaaag tctctaattc 3240
tattaaagtg ctaaggttct aaggcctact tttttttttt tttttttttt tttttttttt 3300
gcgatagagt ctcactgtgt cacccaggct ggagtgcagt ggtgcaatct cgcctcactg 3360
caaccttcac ctaccgagtt caagtgattt tcctgccttg gcctcccaag tagctgggat 3420
tacaggtgtg tgccaccaca cccggctaat ttttatattt ttagtagaga cagggtttca 3480
ccatgttggc caggctggtc taaaactcct gacctcaagt gatctgccca cctcagcctc 3540
ccaaagtgct gagattacag gcatgagcca ctgcactcaa ccttaagacc tactgttcta 3600
aagctctgac attatgtggt tttagatttt ctggttctaa catttttgat aaagcctcaa 3660
ggttttaggt tctaaagttc taagattctg attttaggag ctaaggctct atgagtctag 3720
atgtttattc ttctagagtt cagagtcctt aaaatgtaag attatagatt ctaaagattc 3780
tatagttcta gacatggagg ttctaaggcc taggattcta aaatgtgatg ttctaaggct 3840
ctgagagtct agattctctg gctgtaaggc tctagatcat aaggcttcaa aatgttatct 3900
tctcaagttc taagattcta atgatgatca attatagttt ctgaggcttt atgataatag 3960
attctcttgt ataagatcct agatcctaag ggtcgaaagc tctagaatct gcaattcaaa 4020
agttccaaga gtctaaagat ggagtttcta aggtccggtg ttctaagatg tgatattcta 4080
agacttactc taagatctta gattctctgt gtctaagatt ctagatcaga tgctccaaga 4140
ttctagatga ttaaataaga ttctaacggt ctgttctgtt tcaaggcact ctagattcca 4200
ttggtccaag attccggatc ctaagcatct aagttataag actctcacac tcagttgtga 4260
ctaactagac accaaagttc taataatttc taatgttgga cacctttagg ttctttgctg 4320
cattctgcct ctctaggacc atggttaaga gtccaagaat ccacatttct aaaatcttat 4380
agttctaggc actgtagttc taagactcaa atgttctaag tttctaagat tctaaaggtc 4440
cacaggtcta gactattagg tgcaatttca aggttctaac cctatactgt agtattcttt 4500
ggggtgcccc tctccttctt agctatcatt gcttcctcct ccccaactgt gggggtgtgc 4560
ccccttcaag cctgtgcaat gcattaggga tgcctccttt cccgcagggg atggacgatc 4620
tcccaccttt cgggccatgt tgcccccgtg agccaatccc tcaccttctg agtacagagt 4680
gtggactctg gtgcctccag aggggctcag gtcacataaa actttgtata tcaacgaaaa 4740
aaa                                                               4743

<210> 2
<211> 894
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys
 1               5                  10                  15      
Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala
            20                  25                  30          
Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg
        35                  40                  45              
Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro
    50                  55                  60                  
Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp
65                  70                  75                  80  
Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp
                85                  90                  95      
Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr
            100                 105                 110         
Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser
        115                 120                 125             
Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu
    130                 135                 140                 
Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys
145                 150                 155                 160 
Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp
                165                 170                 175     
Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu
            180                 185                 190         
His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His
        195                 200                 205             
Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu
    210                 215                 220                 
Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu
225                 230                 235                 240 
Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr
                245                 250                 255     
His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln
            260                 265                 270         
Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser
        275                 280                 285             
Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro
    290                 295                 300                 
Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp
305                 310                 315                 320 
Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro
                325                 330                 335     
Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His
            340                 345                 350         
Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg
        355                 360                 365             
Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly
    370                 375                 380                 
Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser
385                 390                 395                 400 
Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro
                405                 410                 415     
Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln
            420                 425                 430         
Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp
        435                 440                 445             
Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val
    450                 455                 460                 
Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg
465                 470                 475                 480 
Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val
                485                 490                 495     
Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr
            500                 505                 510         
Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp
        515                 520                 525             
Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu
    530                 535                 540                 
Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser
545                 550                 555                 560 
Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg
                565                 570                 575     
Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe
            580                 585                 590         
Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser
        595                 600                 605             
Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys
    610                 615                 620                 
His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln
625                 630                 635                 640 
Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile
                645                 650                 655     
Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp
            660                 665                 670         
Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val
        675                 680                 685             
Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg
    690                 695                 700                 
Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser
705                 710                 715                 720 
Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly
                725                 730                 735     
Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly
            740                 745                 750         
Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu
        755                 760                 765             
Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg
    770                 775                 780                 
Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg
785                 790                 795                 800 
Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro
                805                 810                 815     
Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu
            820                 825                 830         
Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro
        835                 840                 845             
Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly
    850                 855                 860                 
Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala
865                 870                 875                 880 
Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala
                885                 890                 


<210> 3
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> V77-2a37.1 heavy chain cDNA

<400> 3
cagctgcagc tgcaggagtc gggcccagga ctggtgaggc cttcggagac cctgtccctc 60
acctgcactg tctctggtgt ctccatcacc aatagcagtt accactgggg ctggatccgc 120
cagcccccag ggaaggggct ggagtggatt gggagtatct tttataatgg gaacaccttc 180
ttcaacccgt ccctcaagag tcgagtcacc ttatccgtcg acacgtccaa gaaccaattc 240
tccctgaaac tgagtcctgt gaccgccgca gacacggctg tgtattactg tgagagacag 300
gataactgga acttccggca ctactttaac tattggggcc agggaaccct ggtcaccgtc 360
tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa 420
actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca 480
gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag 540
tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg gcccagcgag 600
accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg 660
cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc 720
atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt 780
gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat 840
gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc 900
tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc 960
agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc 1020
agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat 1080
aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg 1140
cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat 1200
ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat 1260
actttcacct gctctgtgtt acatgagggt ctgcacaacc accatactga gaagagcctc 1320
tcccactctc ctggtaaa                                               1338

<210> 4
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> V77-2a37.1 heavy chain amino acid

<400> 4
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Ile Thr Asn Ser
            20                  25                  30          
Ser Tyr His Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Ser Ile Phe Tyr Asn Gly Asn Thr Phe Phe Asn Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Leu Ser Val Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Lys Leu Ser Pro Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Glu Arg Gln Asp Asn Trp Asn Phe Arg His Tyr Phe Asn Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro
        115                 120                 125             
Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met
    130                 135                 140                 
Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val
            180                 185                 190         
Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His
        195                 200                 205             
Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys
    210                 215                 220                 
Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe
225                 230                 235                 240 
Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro
                245                 250                 255     
Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val
            260                 265                 270         
Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr
        275                 280                 285             
Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu
    290                 295                 300                 
Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys
305                 310                 315                 320 
Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser
                325                 330                 335     
Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro
            340                 345                 350         
Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile
        355                 360                 365             
Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly
    370                 375                 380                 
Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp
385                 390                 395                 400 
Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp
                405                 410                 415     
Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His
            420                 425                 430         
Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys
        435                 440                 445     


<210> 5
<211> 639
<212> DNA
<213> Artificial Sequence

<220> 
<223> V77-2a37.1 light chain cDNA

<400> 5
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtcggaga cagagtcacc 60
atcacttgcc gggccagtca gagtattagt aactggttgg cctggtatca gcagaaacca 120
gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagag ttcactctca ccatcagcag cctgcagcct 240
gatgattttg ctacttatta ctgccaacag tataatagtt attacacttt tggccagggg 300
accaagctgg agatcaagcg ggctgatgct gcaccaactg tatccatctt cccaccatcc 360
agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc 420
aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac 480
agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg 540
accaaggacg agtatgaacg acataacagc tatacctgtg aggccactca caagacatca 600
acttcaccca ttgtcaagag cttcaacagg aatgagtgt                        639

<210> 6
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> V77-2a37.1 light chain amino acid

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Tyr Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro
            100                 105                 110         
Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly
        115                 120                 125             
Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn
    130                 135                 140                 
Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn
145                 150                 155                 160 
Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr
            180                 185                 190         
Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe
        195                 200                 205             
Asn Arg Asn Glu Cys
    210             


<210> 7
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> V77-2a37.1 heavy chain amino acid

<400> 7
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Ile Thr Asn Ser
            20                  25                  30          
Ser Tyr His Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Ser Ile Phe Tyr Asn Gly Asn Thr Phe Phe Asn Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Leu Ser Val Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Lys Leu Ser Pro Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Glu Arg Gln Asp Asn Trp Asn Phe Arg His Tyr Phe Asn Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro
        115                 120                 125             
Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met
    130                 135                 140                 
Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val
            180                 185                 190         
Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His
        195                 200                 205             
Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys
    210                 215                 220                 
Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe
225                 230                 235                 240 
Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro
                245                 250                 255     
Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val
            260                 265                 270         
Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr
        275                 280                 285             
Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu
    290                 295                 300                 
Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys
305                 310                 315                 320 
Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser
                325                 330                 335     
Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro
            340                 345                 350         
Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile
        355                 360                 365             
Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly
    370                 375                 380                 
Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp
385                 390                 395                 400 
Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp
                405                 410                 415     
Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His
            420                 425                 430         
Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys
        435                 440                 445     


<210> 8
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> V77-2a37.1 heavy chain variable region

<400> 8
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Ile Thr Asn Ser
            20                  25                  30          
Ser Tyr His Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Ser Ile Phe Tyr Asn Gly Asn Thr Phe Phe Asn Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Leu Ser Val Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Lys Leu Ser Pro Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Glu Arg Gln Asp Asn Trp Asn Phe Arg His Tyr Phe Asn Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 9
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> V77-2a37.1 light chain

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Tyr Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro
            100                 105                 110         
Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly
        115                 120                 125             
Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn
    130                 135                 140                 
Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn
145                 150                 155                 160 
Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr
            180                 185                 190         
Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe
        195                 200                 205             
Asn Arg Asn Glu Cys
    210             


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> V77-2a37.1 light chain variable region

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Tyr Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105         


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L1

<400> 11
Arg Ala Ser Gln Ser Ile Ser Asn Trp Leu Ala
 1               5                  10      


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L2

<400> 12
Lys Ala Ser Ser Leu Glu Ser
 1               5          


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L3

<400> 13
Gln Gln Tyr Asn Ser Tyr Tyr Thr
 1               5              


<210> 14
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L1

<400> 14
Arg Ala Ser Gln Ser Ile Ser Asn Trp Leu Ala
 1               5                  10      


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L2

<400> 15
Lys Ala Ser Ser Leu Glu Ser
 1               5          


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L3

<400> 16
Gln Gln Tyr Asn Ser Tyr Tyr Thr
 1               5              


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L1

<400> 17
Ser Asn Trp Leu Ala Trp Tyr
 1               5          


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L2

<400> 18
Leu Leu Ile Tyr Lys Ala Ser Ser Leu Glu
 1               5                  10  


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-L3

<400> 19
Gln Gln Tyr Asn Ser Tyr Tyr
 1               5          


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H1

<400> 20
Asn Ser Ser Tyr His Trp Gly
 1               5          


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H1

<400> 21
Asn Ser Ser Tyr His Trp Gly
 1               5          


<210> 22
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H2

<400> 22
Ser Ile Phe Tyr Asn Gly Asn Thr Phe Phe Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 23
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H3

<400> 23
Gln Asp Asn Trp Asn Phe Arg His Tyr Phe Asn Tyr
 1               5                  10          


<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H1

<400> 24
Gly Val Ser Ile Thr Asn Ser Ser Tyr
 1               5                  


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H1

<400> 25
Gly Val Ser Ile Thr Asn Ser Ser Tyr
 1               5                  


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H2

<400> 26
Phe Tyr Asn Gly Asn
 1               5  


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H3

<400> 27
Gln Asp Asn Trp Asn Phe Arg His Tyr Phe Asn Tyr
 1               5                  10          


<210> 28
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H1

<400> 28
Thr Asn Ser Ser Tyr His Trp Gly
 1               5              


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H1

<400> 29
Thr Asn Ser Ser Tyr His Trp Gly
 1               5              


<210> 30
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H2

<400> 30
Trp Ile Gly Ser Ile Phe Tyr Asn Gly Asn Thr Phe
 1               5                  10          


<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR-H3

<400> 31
Glu Arg Gln Asp Asn Trp Asn Phe Arg His Tyr Phe Asn
 1               5                  10              

