                               SEQUENCE LISTING

<110> MEMORIAL SLOAN-KETTERING CANCER CENTER
 
<120> USE OF PHOSPHOINOSITIDE 3-KINASE INHIBITORS FOR TREATMENT OF 
      VASCULAR MALFORMATIONS

<130> 072734.0395

<140> PCT/US2016/032779
<141> 2016-05-16

<150> 62/313,476
<151> 2016-03-25

<150> 62/265,641
<151> 2015-12-10

<150> 62/162,534
<151> 2015-05-15

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
gtttgtggaa actggatgga gagatttggg gaagcatgga ctctttagcc agcttagttc       60

tctgtggagt cagcttgctc ctttctggta aggtttggct ttattttttt taatttagta      120

t                                                                      121


<210> 2
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
gattattgtc tctctttcct tttaggaact gtggaaggtg ccatggactt gatcttgatc       60

aattccctac ctcttgtatc tgatgctgaa acatctctca cctgcattgc ctctgggtgg      120

c                                                                      121


<210> 3
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
ggcccccatg agcccatcac cataggaagg gactttgaag ccttaatgaa ccagcaccag       60

gatccgctgg aagttactca agatgtgacc agagaatggg ctaaaaaagt tgtttggaag      120

a                                                                      121


<210> 4
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
ggagaaaagg ctagtaagat caatggtgct tatttctgtg aagggcgagt tcgaggagag       60

gcaatcagga tacgaaccat gaagatgcgt caacaaggta acatgcccct aagttttggg      120

c                                                                      121


<210> 5
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
gaaagcttcc ttcctaccag ctactttaac tatgactgtg gacaagggag ataacgtgaa       60

catatctttc aaaaaggtat tgattaaaga agaagatgca gtgatttaca aaaatggtga      120

g                                                                      121


<210> 6
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
gtgtttcagt gtgacctacg gttcttcact cttccctctt actaggttcc ttcatccatt       60

cagtgccccg gcatgaagta cctgatattc tagaagtaca cctgcctcat gctcagcccc      120

a                                                                      121


<210> 7
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gggatgctgg agtgtactcg gccaggtata taggaggaaa cctcttcacc tcggccttca       60

ccaggctgat agtccggagt aagtgatgga gaggccacca tttgtgatgg tgtagttgtt      120

a                                                                      121


<210> 8
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
gatgtgttga gcgaatgcgc tctactcacc acagccttgt tttccttaac aaaaggatgt       60

gaagcccaga agtggggacc tgaatgcaac catctctgta ctgcttgtat gaacaatggt      120

g                                                                      121


<210> 9
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
gtctgccatg aagatactgg agaatgcatt tgccctcctg ggtttatggg aaggacgtgt       60

gagaagggta agtaaagaga cttgataagt aagctgtgga tttaaaaagc catcgttgct      120

g                                                                      121


<210> 10
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
gcaaggggtt gcatatttga ctctgaatca tcttttcttt tcctcccaaa gcttgtgaac       60

tgcacacgtt tggcagaact tgtaaagaaa ggtgcagtgg acaagaggga tgcaagtctt      120

a                                                                      121


<210> 11
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gtgtgttctg tctccctgac ccctatgggt gttcctgtgc cacaggctgg aagggtctgc       60

agtgcaatga aggtatgcac caatcacacc cttggacaga ggatgttcta gcaggtatat      120

a                                                                      121


<210> 12
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gttagtttcc tctcttcccc tggattaata ctggtttttt gatgtctctg tttacagcat       60

gccaccctgg tttttacggg ccagattgta agcttaggtg cagctgcaac aatggggaga      120

t                                                                      121


<210> 13
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
ggtgtgatcg cttccaagga tgtctctgct ctccaggatg gcaggggctc cagtgtgaga       60

gagaaggtaa agcaaggtaa cactgtagtc agggccatgt tcagcatgtc tgaactgagc      120

t                                                                      121


<210> 14
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
gctctgttaa atattagatt tcacagtgct gttttcttcc ttcaggcata cagaggatga       60

ccccaaagat agtggatttg ccagatcata tagaagtaaa cagtggtaaa tttaatccca      120

t                                                                      121


<210> 15
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
gttgcaaagc ttctggctgg ccgctaccta ctaatgaaga aatgaccctg gtgaagccgg       60

atgggacagt gctccatgta agagccattc ttaatttgcc cttcttaaag catgagatgc      120

t                                                                      121


<210> 16
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
gtttatgcct ccctagaagt ttttattttt ttgtatttga ccttttcagc caaaagactt       60

taaccatacg gatcatttct cagtagccat attcaccatc caccggatcc tcccccctga      120

c                                                                      121


<210> 17
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
gtcaggagtt tgggtctgca gtgtgaacac agtggctggg atggtggaaa agcccttcaa       60

catttctgtt aaaggtaagt tcatttccca gaaaaaggga ttgtgtcctt gatgcattat      120

g                                                                      121


<210> 18
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
gaagccgaag gactaatctg ccttctgaaa ttgtatttag ttcttccaaa gcccctgaat       60

gccccaaacg tgattgacac tggacataac tttgctgtca tcaacatcag ctctgagcct      120

t                                                                      121


<210> 19
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
gactttgggg atggaccaat caaatccaag aagcttctat acaaacccgt taatcactat       60

gaggcttggc aacatattca aggtaagctt tggacaggat agatgccagc tggggatgtg      120

g                                                                      121


<210> 20
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
gaggaatgta agagaatgcc aacttaagtt tcctggacgt tttctcttct cagtgacaaa       60

tgagattgtt acactcaact atttggaacc tcggacagaa tatgaactct gtgtgcaact      120

g                                                                      121


<210> 21
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
ggtccgtcgt ggagagggtg gggaagggca tcctggacct gtgagacgct tcacaacagc       60

ttctatcggt cagtggaagc caacaggcat ttattcatga gctgggtggg agggggagga      120

a                                                                      121


<210> 22
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
gccatatata aaaataatga tttttctgga ttctcctagg actccctcct ccaagaggtc       60

taaatctcct gcctaaaagt cagaccactc taaatttgac ctggcaacca atatttccaa      120

g                                                                      121


<210> 23
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
gctcggaaga tgacttttat gttgaagtgg agagaaggtc tgtgcaaaaa agtgatcagc       60

agaatattaa agttccaggc aacttgactt cggtgctact taacaactta catcccaggg      120

a                                                                      121


<210> 24
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
ggcagtacgt ggtccgagct agagtcaaca ccaaggccca gggggaatgg agtgaagatc       60

tcactgcttg gacccttagt gacagtaagt aattcatgct gctccagcct catctgagca      120

a                                                                      121


<210> 25
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
gaagtgaatc ttttttcttt ttaatttcta gttcttcctc ctcaaccaga aaacatcaag       60

atttccaaca ttacacactc ctcagctgtg atttcttgga caatattgga tggctattct      120

a                                                                      121


<210> 26
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
gtttcttcta ttactatccg ttacaaggtt caaggcaaga atgaagacca gcacgttgat       60

gtgaagataa agaatgccac catcactcag tatcagctca agggcctaga gcctgaaaca      120

g                                                                      121


<210> 27
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
gcataccagg tggacatttt tgcagagaac aacatagggt caagcaaccc agccttttct       60

catgaactgg tgaccctccc agaatctcaa ggttggttga atggacaagt atttacatag      120

g                                                                      121


<210> 28
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
gtgtaaacta aactacctgc ttcacctctg tcttcctgca cagcaccagc ggacctcgga       60

ggggggaaga tgctgcttat agccatcctt ggctctgctg gaatgacctg cctgactgtg      120

c                                                                      121


<210> 29
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
gtgttggcct ttctgatcat attgcaattg aagagggcaa atgtgcaaag gagaatggcc       60

caagccttcc aaaacgtggt agtgtctcat cttcctacta gctaataagg gcaagtccaa      120

g                                                                      121


<210> 30
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
gaattatttt tccagaggga agaaccagct gtgcagttca actcagggac tctggcccta       60

aacaggaagg tcaaaaacaa cccagatcct acaatttatc cagtgcttga ctggaatgac      120

a                                                                      121


<210> 31
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
gtcaaatttc aagatgtgat tggggagggc aattttggcc aagttcttaa ggcgcgcatc       60

aagaaggatg ggttacggat ggatgctgcc atcaaaagaa tgaaaggtca gtggttgacc      120

a                                                                      121


<210> 32
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
gccagaatat gcctccaaag atgatcacag ggactttgca ggagaactgg aagttctttg       60

taaacttgga caccatccaa acatcatcaa tctcttagga gcatgtgaac atcgaggtaa      120

g                                                                      121


<210> 33
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
gcgatgctct cttccttccc tccaggctac ttgtacctgg ccattgagta cgcgccccat       60

ggaaaccttc tggacttcct tcgcaagagc cgtgtgctgg agacggaccc agcatttgcc      120

a                                                                      121


<210> 34
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
gttgccaata gcaccgcgtc cacactgtcc tcccagcagc tccttcactt cgctgccgac       60

gtggcccggg gcatggacta cttgagccaa aaacaggttt gtccggagga cttcgctttg      120

g                                                                      121


<210> 35
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
gcagtttatc cacagggatc tggctgccag aaacatttta gttggtgaaa actatgtggc       60

aaaaatagca gattttggat tgtcccgagg tcaagaggtg tatgtgaaaa agacaatggt      120

a                                                                      121


<210> 36
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
ggaaatctca ctttgttctc tccagggaag gctcccagtg cgctggatgg ccatcgagtc       60

actgaattac agtgtgtaca caaccaacag tgatgtgtga gtaaacttct tattgccaag      120

g                                                                      121


<210> 37
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
gtgtttgctg attgttggtt tcacacttgt ccctcctgca gatggtccta tggtgtgtta       60

ctatgggaga ttgttagctt aggtgagtat ctatgtttat ctaccaggtg agactctagg      120

c                                                                      121


<210> 38
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
gtttgtcttc caggaggcac accctactgc gggatgactt gtgcagaact ctacgagaag       60

ctgccccagg gctacagact ggagaagccc ctgaactgtg atgatgaggt gtaagtcagg      120

c                                                                      121


<210> 39
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
ggctttcgaa ggtatgatct aatgagacaa tgctggcggg agaagcctta tgagaggcca       60

tcatttgccc agatattggt gtccttaaac agaatgttag aggagcgaaa ggtaagtatt      120

a                                                                      121


<210> 40
<211> 121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
gtgaaccatt ttcattcttc cagacctacg tgaataccac gctttatgag aagtttactt       60

atgcaggaat tgactgttct gctgaagaag cggcctagga cagaacatct gtataccctc      120

t                                                                      121


