                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHODS RELATING TO THE DIAGNOSIS AND TREATMENT OF THROMBOTIC 
      MICROANGIOPATHY

<130> 701039-084711-PCT

<140>
<141>

<150> 62/162,151
<151> 2015-05-15

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 4966
<212> DNA
<213> Homo sapiens

<400> 1
aaccacgatg tctttggcac agcctctcat ctgtcagatg ggagcgggga ccccggagag       60

ggagtcagcc gaggtcctgg cattccttgt gaacccccgt ctgtgggttt ctggtccagt      120

gtcccttctc cagattagat ggcttaggcc tcctctaagg gggtgggcgt gcacatccgg      180

agagctgtct ggtgtgcagg actgggctgc aggttaccct gaactgcaac catcttagag      240

caaggcccag cttgcagcag gaggagctgc aggccgccca ccctagccac ggcccctgcc      300

ctggcaggaa gcttccaaga gtaaacactg cctaatcgtc ccgcccagta gtgagcaggc      360

ctgtcccatt ccatactgac cagattccca gtcaccaagg ccccctctca ctccgctcca      420

ctcctcgggc tggctctcct gaggatgcac cagcgtcacc cccgggcaag atgccctccc      480

ctctgtgtgg ccggaatcct tgcctgtggc tttctcctgg gctgctgggg accctcccat      540

ttccagcaga gttgtcttca ggctttggag ccacaggccg tgtcttctta cttgagccct      600

ggtgctccct taaaaggccg ccctccttcc cctggcttcc agaggcagag gcagaggcag      660

aggcgggctg caggcggcat cctacacctg gagctgctgg tggccgtggg ccccgatgtc      720

ttccaggctc accaggagga cacagagcgc tatgtgctca ccaacctcaa catcggggca      780

gaactgcttc gggacccgtc cctgggggct cagtttcggg tgcacctggt gaagatggtc      840

attctgacag agcctgaggg tgctccaaat atcacagcca acctcacctc gtccctgctg      900

agcgtctgtg ggtggagcca gaccatcaac cctgaggacg acacggatcc tggccatgct      960

gacctggtcc tctatatcac taggtttgac ctggagttgc ctgatggtaa ccggcaggtg     1020

cggggcgtca cccagctggg cggtgcctgc tccccaacct ggagctgcct cattaccgag     1080

gacactggct tcgacctggg agtcaccatt gcccatgaga ttgggcacag cttcggcctg     1140

gagcacgacg gcgcgcccgg cagcggctgc ggccccagcg gacacgtgat ggcttcggac     1200

ggcgccgcgc cccgcgccgg cctcgcctgg tccccctgca gccgccggca gctgctgagc     1260

ctgctcagcg caggacgggc gcgctgcgtg tgggacccgc cgcggcctca acccgggtcc     1320

gcggggcacc cgccggatgc gcagcctggc ctctactaca gcgccaacga gcagtgccgc     1380

gtggccttcg gccccaaggc tgtcgcctgc accttcgcca gggagcacct ggatatgtgc     1440

caggccctct cctgccacac agacccgctg gaccaaagca gctgcagccg cctcctcgtt     1500

cctctcctgg atgggacaga atgtggcgtg gagaagtggt gctccaaggg tcgctgccgc     1560

tccctggtgg agctgacccc catagcagca gtgcatgggc gctggtctag ctggggtccc     1620

cgaagtcctt gctcccgctc ctgcggagga ggtgtggtca ccaggaggcg gcagtgcaac     1680

aaccccagac ctgcctttgg ggggcgtgca tgtgttggtg ctgacctcca ggccgagatg     1740

tgcaacactc aggcctgcga gaagacccag ctggagttca tgtcgcaaca gtgcgccagg     1800

accgacggcc agccgctgcg ctcctcccct ggcggcgcct ccttctacca ctggggtgct     1860

gctgtaccac acagccaagg ggatgctctg tgcagacaca tgtgccgggc cattggcgag     1920

agcttcatca tgaagcgtgg agacagcttc ctcgatggga cccggtgtat gccaagtggc     1980

ccccgggagg acgggaccct gagcctgtgt gtgtcgggca gctgcaggac atttggctgt     2040

gatggtagga tggactccca gcaggtatgg gacaggtgcc aggtgtgtgg tggggacaac     2100

agcacgtgca gcccacggaa gggctctttc acagctggca gagcgagaga atatgtcacg     2160

tttctgacag ttacccccaa cctgaccagt gtctacattg ccaaccacag gcctctcttc     2220

acacacttgg cggtgaggat cggagggcgc tatgtcgtgg ctgggaagat gagcatctcc     2280

cctaacacca cctacccctc cctcctggag gatggtcgtg tcgagtacag agtggccctc     2340

accgaggacc ggctgccccg cctggaggag atccgcatct ggggacccct ccaggaagat     2400

gctgacatcc aggtttacag gcggtatggc gaggagtatg gcaacctcac ccgcccagac     2460

atcaccttca cctacttcca gcctaagcca cggcaggcct gggtgtgggc cgctgtgcgt     2520

gggccctgct cggtgagctg tggggcaggg ctgcgctggg taaactacag ctgcctggac     2580

caggccagga aggagttggt ggagactgtc cagtgccaag ggagccagca gccaccagcg     2640

tggccagagg cctgcgtgct cgaaccctgc cctccctact gggcggtggg agacttcggc     2700

ccatgcagcg cctcctgtgg gggtggcctg cgggagcggc cagtgcgctg cgtggaggcc     2760

cagggcagcc tcctgaagac attgccccca gcccggtgca gagcaggggc ccagcagcca     2820

gctgtggcgc tggaaacctg caacccccag ccctgccctg ccaggtggga ggtgtcagag     2880

cccagctcat gcacatcagc tggtggagca ggcctggcct tggagaacga gacctgtgtg     2940

ccaggggcag atggcctgga ggctccagtg actgaggggc ctggctccgt agatgagaag     3000

ctgcctgccc ctgagccctg tgtcgggatg tcatgtcctc caggctgggg ccatctggat     3060

gccacctctg caggggagaa ggctccctcc ccatggggca gcatcaggac gggggctcaa     3120

gctgcacacg tgtggacccc tgcggcaggg tcgtgctccg tctcctgcgg gcgaggtctg     3180

atggagctgc gtttcctgtg catggactct gccctcaggg tgcctgtcca ggaagagctg     3240

tgtggcctgg caagcaagcc tgggagccgg cgggaggtct gccaggctgt cccgtgccct     3300

gctcggtggc agtacaagct ggcggcctgc agcgtgagct gtgggagagg ggtcgtgcgg     3360

aggatcctgt attgtgcccg ggcccatggg gaggacgatg gtgaggagat cctgttggac     3420

acccagtgcc aggggctgcc tcgcccggaa ccccaggagg cctgcagcct ggagccctgc     3480

ccacctaggt ggaaagtcat gtcccttggc ccatgttcgg ccagctgtgg ccttggcact     3540

gctagacgct cggtggcctg tgtgcagctc gaccaaggcc aggacgtgga ggtggacgag     3600

gcggcctgtg cggcgctggt gcggcccgag gccagtgtcc cctgtctcat tgccgactgc     3660

acctaccgct ggcatgttgg cacctggatg gagtgctctg tttcctgtgg ggatggcatc     3720

cagcgccggc gtgacacctg cctcggaccc caggcccagg cgcctgtgcc agctgatttc     3780

tgccagcact tgcccaagcc ggtgactgtg cgtggctgct gggctgggcc ctgtgtggga     3840

cagggtacgc ccagcctggt gccccacgaa gaagccgctg ctccaggacg gaccacagcc     3900

acccctgctg gtgcctccct ggagtggtcc caggcccggg gcctgctctt ctccccggct     3960

ccccagcctc ggcggctcct gcccgggccc caggaaaact cagtgcagtc cagtgcctgt     4020

ggcaggcagc accttgagcc aacaggaacc attgacatgc gaggcccagg gcaggcagac     4080

tgtgcagtgg ccattgggcg gcccctcggg gaggtggtga ccctccgcgt ccttgagagt     4140

tctctcaact gcagtgcggg ggacatgttg ctgctttggg gccggctcac ctggaggaag     4200

atgtgcagga agctgttgga catgactttc agctccaaga ccaacacgct ggtggtgagg     4260

cagcgctgcg ggcggccagg aggtggggtg ctgctgcggt atgggagcca gcttgctcct     4320

gaaaccttct acagagaatg tgacatgcag ctctttgggc cctggggtga aatcgtgagc     4380

ccctcgctga gtccagccac gagtaatgca gggggctgcc ggctcttcat taatgtggct     4440

ccgcacgcac ggattgccat ccatgccctg gccaccaaca tgggcgctgg gaccgaggga     4500

gccaatgcca gctacatctt gatccgggac acccacagct tgaggaccac agcgttccat     4560

gggcagcagg tgctctactg ggagtcagag agcagccagg ctgagatgga gttcagcgag     4620

ggcttcctga aggctcaggc cagcctgcgg ggccagtact ggaccctcca atcatgggta     4680

ccggagatgc aggaccctca gtcctggaag ggaaaggaag gaacctgagg gtcattgaac     4740

atttgttccg tgtctggcca gccctggagg gttgacccct ggtctcagtg ctttccaatt     4800

cgaacttttt ccaatcttag gtatctactt tagagtcttc tccaatgtcc aaaaggctag     4860

ggggttggag gtggggactc tggaaaagca gcccccattt cctcgggtac caataaataa     4920

aacatgcagg ctgaccggcg tttttttctt aaaaaaaaaa aaaaaa                    4966


<210> 2
<211> 1427
<212> PRT
<213> Homo sapiens

<400> 2
Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
    1415                 1420                 1425         


<210> 3
<211> 6499
<212> DNA
<213> Homo sapiens

<400> 3
atcgaggtcc gcgggaggct cggagcgcgc caggcggaca ctcctctcgg ctcctccccg       60

gcagcggcgg cggctcggag cgggctccgg ggctcgggtg cagcggccag cgggcgcctg      120

gcggcgagga ttacccgggg aagtggttgt ctcctggctg gagccgcgag acgggcgctc      180

agggcgcggg gccggcggcg gcgaacgaga ggacggactc tggcggccgg gtcgttggcc      240

gcggggagcg cgggcaccgg gcgagcaggc cgcgtcgcgc tcaccatggt cagctactgg      300

gacaccgggg tcctgctgtg cgcgctgctc agctgtctgc ttctcacagg atctagttca      360

ggttcaaaat taaaagatcc tgaactgagt ttaaaaggca cccagcacat catgcaagca      420

ggccagacac tgcatctcca atgcaggggg gaagcagccc ataaatggtc tttgcctgaa      480

atggtgagta aggaaagcga aaggctgagc ataactaaat ctgcctgtgg aagaaatggc      540

aaacaattct gcagtacttt aaccttgaac acagctcaag caaaccacac tggcttctac      600

agctgcaaat atctagctgt acctacttca aagaagaagg aaacagaatc tgcaatctat      660

atatttatta gtgatacagg tagacctttc gtagagatgt acagtgaaat ccccgaaatt      720

atacacatga ctgaaggaag ggagctcgtc attccctgcc gggttacgtc acctaacatc      780

actgttactt taaaaaagtt tccacttgac actttgatcc ctgatggaaa acgcataatc      840

tgggacagta gaaagggctt catcatatca aatgcaacgt acaaagaaat agggcttctg      900

acctgtgaag caacagtcaa tgggcatttg tataagacaa actatctcac acatcgacaa      960

accaatacaa tcatagatgt ccaaataagc acaccacgcc cagtcaaatt acttagaggc     1020

catactcttg tcctcaattg tactgctacc actcccttga acacgagagt tcaaatgacc     1080

tggagttacc ctgatgaaaa aaataagaga gcttccgtaa ggcgacgaat tgaccaaagc     1140

aattcccatg ccaacatatt ctacagtgtt cttactattg acaaaatgca gaacaaagac     1200

aaaggacttt atacttgtcg tgtaaggagt ggaccatcat tcaaatctgt taacacctca     1260

gtgcatatat atgataaagc attcatcact gtgaaacatc gaaaacagca ggtgcttgaa     1320

accgtagctg gcaagcggtc ttaccggctc tctatgaaag tgaaggcatt tccctcgccg     1380

gaagttgtat ggttaaaaga tgggttacct gcgactgaga aatctgctcg ctatttgact     1440

cgtggctact cgttaattat caaggacgta actgaagagg atgcagggaa ttatacaatc     1500

ttgctgagca taaaacagtc aaatgtgttt aaaaacctca ctgccactct aattgtcaat     1560

gtgaaacccc agatttacga aaaggccgtg tcatcgtttc cagacccggc tctctaccca     1620

ctgggcagca gacaaatcct gacttgtacc gcatatggta tccctcaacc tacaatcaag     1680

tggttctggc acccctgtaa ccataatcat tccgaagcaa ggtgtgactt ttgttccaat     1740

aatgaagagt cctttatcct ggatgctgac agcaacatgg gaaacagaat tgagagcatc     1800

actcagcgca tggcaataat agaaggaaag aataagatgg ctagcacctt ggttgtggct     1860

gactctagaa tttctggaat ctacatttgc atagcttcca ataaagttgg gactgtggga     1920

agaaacataa gcttttatat cacagatgtg ccaaatgggt ttcatgttaa cttggaaaaa     1980

atgccgacgg aaggagagga cctgaaactg tcttgcacag ttaacaagtt cttatacaga     2040

gacgttactt ggattttact gcggacagtt aataacagaa caatgcacta cagtattagc     2100

aagcaaaaaa tggccatcac taaggagcac tccatcactc ttaatcttac catcatgaat     2160

gtttccctgc aagattcagg cacctatgcc tgcagagcca ggaatgtata cacaggggaa     2220

gaaatcctcc agaagaaaga aattacaatc agaggtgagc actgcaacaa aaaggctgtt     2280

ttctctcgga tctccaaatt taaaagcaca aggaatgatt gtaccacaca aagtaatgta     2340

aaacattaaa ggactcatta aaaagtaaca gttgtctcat atcatcttga tttattgtca     2400

ctgttgctaa ctttcaggct cggaggagat gctcctccca aaatgagttc ggagatgata     2460

gcagtaataa tgagaccccc gggccccagc tctgggcccc ccattcaggc cgagggggct     2520

gctccggggg gccgacttgg tgcacgtttg gatttggagg atccctgcac tgccttctct     2580

gtgtttgttg ctcttgctgt tttctcctgc ctgataaaca acaacttggg atgatccttt     2640

ccttccattt tgatgccaac ctctttttat ttttaagtgt tgaagctgca caaactgaat     2700

aatttaaaca aatgctggtt tctgccaaag atggacacga ataagttaat tttccagctc     2760

agaatgagta cagttgaatt tgagactctg tcggacttct gcctggtttt atttgggact     2820

atttcatctg ctcttgattt gtaaatagca cctggatagc aagttataat gcttatttat     2880

ttgaaaatgc tttttttttt tttacgttaa gcacatttat cttgaactgg agcttctaaa     2940

atgggcccca ggggtgcaag atgttggtgt aattcagaga tagtaaaggt ttatcgcagt     3000

gtgaattata agagtccatc caaatcaacg tcccctccct cctctcatgc gatccaggta     3060

attatgcagt tagtgccaca gtagactagc ctagcaaagg gtttgctcct tgctgtctct     3120

gactgcacca cacagctatt gatggcagct gaaagaaagt ggatcatgcc ttaattttaa     3180

atattcctgt cctctggtta ttattttaag gaacttcatc atgttaaaat gacagcattc     3240

aaaggtgtac cacaatcaat ttatcaagga aataaaggct attgtaacca gagatttaat     3300

gcattcttct aaatgtaaat ttaaaatttg ccctttaaaa aagtccactt tccccatatg     3360

caaatgttaa taggattttt atggggatta agaagcggca aaactacaga agcagaattc     3420

aaagtaattt aaaaaataca caccagtttt aaatcaagag aagttgtaat ctcttgtttt     3480

aagcttgcgt ttgagggaaa atgacttttt caccaattta atatgcattg ttctgttgtt     3540

tttatttatg attgatcatt atatgtgact tgcataaact atttaaaaaa aaaaactata     3600

atgaccaaaa tagccatggc tgagaaacac agtggctggg cagttcaata ggaggtgaca     3660

atatgacaac ttctcaagct tgggaactca ccagactgtt tcctccttta ggtaacagat     3720

tctgtcccac ggctaaactt gtctttcacg tgggaattgc ttttgtcaaa cgtgaaagag     3780

taaacaatag catttcccca gaatgccagt tttatggagc cccaaatgct ctgaaaacaa     3840

ttagtaacct ggaagttgtc agcccaaagg aaagaaaaat caattgtatc ttgaaatttt     3900

acctatggct ctttggcctg gcttctttgt tcattataag ttagtgtgtt ccttcaggaa     3960

acaatgcctt aataccatag aacatggggg ccttaatagt tgctaacatt aaaaaagcaa     4020

acagaatgat tgagggatcc ttatgaaaac aaaatggtga attggacatg cagaacctac     4080

catttccttc ccctgtttgc aatttttgtg gggaggggag gatgttagta tttacaaaag     4140

atgattttaa gaacttccaa gagatgagtt taagaattcc atagagtatt agttgttcac     4200

tgtgtaatta atccttccgg agagtctttt tttttttttt taaagaaact tttgggtggg     4260

ttttgttttt tattagttac cctaggggta tgttaccctg gggtatgaag ggaggtgaag     4320

ataacggagg ggggagaaaa aaaaaaggag aaaaaaggag cctaaaatgg ggaataattg     4380

aaatggaaca gggggtgtga ggctggttcc tcagtcccca ttccaaacgg aggatagaag     4440

ctgtgtattt atgtgacctg gcagatctct ggggccataa cactgaaaag tgaaagaacc     4500

tggtgggcag ctatctttgg ctactgataa ccagcagaaa tgtctgttaa ttctgatttt     4560

ctcaatttga agggatcagc tacactgtta aattttggaa agccactacc tacttccatc     4620

aagtaactta ggtttcgaaa tatgggttca acgcacctcc cttattcaaa atgtcaaaat     4680

agattattat aatgtataaa gtaagaattg acaaaatatg attcttgggt tgattggtca     4740

tttagaaact agccaaaagt gagactttta atgtagaaca tttttcagaa atgggtacaa     4800

agaaaaatgc atattactgt atatttcaga gtgtttatgt gaaccttgta tttaattgag     4860

agtcccatgt acgttctgca gcctttttgc tgcttctatc atctgaagtt tgtgtagtac     4920

aaataaggcc tttgggattc ttaatgacat ttatgttaaa atgttctctt ctctttaaac     4980

accgttttcc aatccacctg tcagggagtc caaatcgtgt ctgtgttgat gatgctatac     5040

tttgtagcta gaaaaacaat tttagtgttg tgggctctgt attcagactt cctttttaca     5100

agaccgatgg gcagtgatag attattttat catatttaat gcatgggaaa tagtgtgctg     5160

aggaagctat taaaagtata actcagtgaa ttgggtctga gttttaaatg agatatttca     5220

aaattggctt gccactgtaa aagcgactaa ataataatat gatactgttc tttatgatct     5280

tgtcatgttt cactgatatg tttggggtct tcactatgta aaaaatgtca aaattgtaat     5340

gagcaagcat gtacaagtag tcgtaaatca aaggttttaa acaggactgc attttcaatt     5400

aggaaaagct gtttggcaga tagcatccaa tgcaaaaaca gaaatatcgt aacgttctgc     5460

ttagtgggca agataagata ggaaagacat gctcaaagag gcaaaagaat cattgctatc     5520

attcattcta cactagtttg aagaagtttt tgtacatcag agcacttcct tcagcacact     5580

tttttgcctt cagatttcat tttttataaa atgagaagac taatgataaa ctgtagaaat     5640

caaaatttat tgagaaatct gtttctccta acagatagta accctgccat gatatactac     5700

ttcaacaatg ttataaaatt tatgtgataa tatacatttt aacctgggat ttctaaattg     5760

ctttaacaaa tgctaatcct gagagttgcc ctgcaggact caaaagggaa aggttttggg     5820

acgtggcaga accctgcagg gacatggaat taaggccatt gcaatgtatc atctttgtag     5880

cattgtcatc actcctaagc tgccttcaca gttttagtac actaagatga ggaaatcgaa     5940

aatgggcaga gaaagctcat actgtataat tgaagacagt gacagagaac gtgtcagtta     6000

tgccaaaact cttttgattt ctgttccagg atttccaaca agaggggaaa ggaatgactt     6060

gggagggtgg gaaagacatt aggagttgtt tttatttttt accttggaag ctttagctac     6120

caatccagta ccctcctaac tagaatgtat acacatcagc aggactgact gactacttca     6180

ttagagatat actgtactca ttgggggcct tgggggtact gctgttctta tgtgggattt     6240

taatgttgta atgtattgca tcttaatgta ttgaattcat tttgttgtac tatattggtt     6300

ggcattttat taaaataaat tgtattgtat catatttgta tgttttaaga gaaaataata     6360

taaaatacaa tatttgtact attatatagt gcaaaaacta caaatctgtg cctctgcctc     6420

ttgaattaat tctttggttg cttgcatttg ggaagggaat ggagaaagga aagaaccaat     6480

aaagctttca aagttcaag                                                  6499


<210> 4
<211> 687
<212> PRT
<213> Homo sapiens

<400> 4
Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Gly Glu His Cys Asn Lys Lys Ala Val Phe Ser Arg Ile Ser Lys Phe 
            660                 665                 670         


Lys Ser Thr Arg Asn Asp Cys Thr Thr Gln Ser Asn Val Lys His 
        675                 680                 685         


