                         SEQUENCE LISTING

<110>  The Medical Research, Infrastructure and Health Services
       Fund of the Tel Aviv Medical Center
       ARBER, Nadir
       SHAPIRA, Shiran
       KAZANOV, Dina
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER

<130>  66324

<150>  US 62/162,765
<151>  2015-05-17

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ets binding site

<400>  1
caggaag                                                                  7


<210>  2
<211>  8
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AP-1 binding site

<400>  2
tgactaag                                                                 8


<210>  3
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PY2 sequence

<400>  3
caggaagtga ctaag                                                        15


<210>  4
<211>  203
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SV40 minimal promoter

<400>  4
gcgatctgca tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc       60

ccctaactcc gcccagttcc gcccattctc cgccccatcg ctgactaatt ttttttattt      120

atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt      180

ttggaggcct aggcttttgc aaa                                              203


<210>  5
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mCherry coding sequence

<400>  5
atgggaattc acgtgagcaa gggcgaggag gataacatgg ccatcatcaa ggagttcatg       60

cgcttcaagg tgcacatgga gggctccgtg aacggccacg agttcgagat cgagggcgag      120

ggcgagggcc gcccctacga gggcacccag accgccaagc tgaaggtgac caagggtggc      180

cccctgccct tcgcctggga catcctgtcc cctcagttca tgtacggctc caaggcctac      240

gtgaagcacc ccgccgacat ccccgactac ttgaagctgt ccttccccga gggcttcaag      300

tgggagcgcg tgatgaactt cgaggacggc ggcgtggtga ccgtgaccca ggactcctcc      360

ctgcaggacg gcgagttcat ctacaaggtg aagctgcgcg gcaccaactt cccctccgac      420

ggccccgtaa tgcagaagaa gaccatgggc tgggaggcct cctccgagcg gatgtacccc      480

gaggacggcg ccctgaaggg cgagatcaag cagaggctga agctgaagga cggcggccac      540

tacgacgctg aggtcaagac cacctacaag gccaagaagc ccgtgcagct gcccggcgcc      600

tacaacgtca acatcaagtt ggacatcacc tcccacaacg aggactacac catcgtggaa      660

cagtacgaac gcgccgaggg ccgccactcc accggcggca tggacgagct gtacaag         717


<210>  6
<211>  342
<212>  DNA
<213>  Artificial sequence

<220>
<223>  E. coli MazF ribonuclease

<400>  6
atggtaagcc gatacgtacc cgatatgggc gatctgattt gggttgattt tgacccgaca       60

aaaggtagcg agcaagctgg acatcgtcca gctgttgtcc tgagtccttt catgtacaac      120

aacaaaacag gtatgtgtct gtgtgttcct tgtacaacgc aatcaaaagg atatccgttc      180

gaagttgttt tatccggtca ggaacgtgat ggcgtagcgt tagctgatca ggtaaaaagt      240

atcgcctggc gggcaagagg agcaacgaag aaaggaacag ttgccccaga ggaattacaa      300

ctcattaaag ccaaaattaa cgtactgatt ggcaccggtt ag                         342


<210>  7
<211>  588
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IRES

<400>  7
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg      540

gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaacc                   588


<210>  8
<211>  657
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tetracycline repressor

<400>  8
atgagcagat tagataaaag taaagtgatt aacagcgcat tagagctgct taatgaggtc       60

ggaatcgaag gtttaacaac ccgtaaactc gcccagaagc taggtgtaga gcagcctaca      120

ttgtattggc atgtaaaaaa taagcgggct ttgctcgacg ccttagccat tgagatgtta      180

gataggcacc atactcactt ttgcccttta gaaggggaaa gctggcaaga ttttttacgt      240

aataacgcta aaagttttag atgtgcttta ctaagtcatc gcgatggagc aaaagtacat      300

ttaggtacac ggcctacaga aaaacagtat gaaactctcg aaaatcaatt agccttttta      360

tgccaacaag gtttttcact agagaatgca ttatatgcac tcagcgctgt ggggcatttt      420

actttaggtt gcgtattgga agatcaagag catcaagtcg ctaaagaaga aagggaaaca      480

cctactactg atagtatgcc gccattatta cgacaagcta tcgaattatt tgatcaccaa      540

ggtgcagagc cagccttctt attcggcctt gaattgatca tatgcggatt agaaaaacaa      600

cttaaatgtg aaagtgggtc cgcgtacagc ggatcccggg aattcagatc ttattaa         657


<210>  9
<211>  241
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV minimal promoter+2xtetracycline operator

<400>  9
accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg       60

gcggtaggcg tgtacggtgg gaggtctata taagcagagc tctccctatc agtgatagag      120

atctccctat cagtgataga gatcgtcgac gagctcgttt agtgaaccgt cagatcgcct      180

ggagacgcca tccacgctgt tttgacctcc atagaagaca ccgggaccga tccagcctcc      240

g                                                                      241


<210>  10
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  2xtetracycline operator

<400>  10
tccctatcag tgatagagat ctccctatca gtgatagaga tc                          42


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  tetracycline operator

<400>  11
tccctatcag tgatagagat c                                                 21


<210>  12
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GFP coding sequence

<400>  12
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaag         717


<210>  13
<211>  249
<212>  DNA
<213>  Artificial sequence

<220>
<223>  E. coli antitoxin MazE

<400>  13
atgatccaca gtagcgtaaa gcgttgggga aattcaccgg cggtgcggat cccggctacg       60

ttaatgcagg cgctcaatct gaatattgat gatgaagtga agattgacct ggtggatggc      120

aaattaatta ttgagccagt gcgtaaagag cccgtattta cgcttgctga actggtcaac      180

gacatcacgc cggaaaacct ccacgagaat atcgactggg gagagccgaa agataaggaa      240

gtctggtaa                                                              249


<210>  14
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  p53 wild type responsive element

<400>  14
cctgcctgga cttgcctgg                                                    19


<210>  15
<211>  325
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RGCx17 (17 repeats of the p53 WT responsive element)

<400>  15
cctgcctgga cttgcctggc ctgcctggac ttgcctggcc tgcctggact tgcctggcct       60

gcctggactt gcctggcctg cctggacttg cctggcctgc ctggacttgc ctggcctgcc      120

tggacttgcc tggcctgcct ggacttgcct ggcctgcctg gacttgcctg gcccctgcct      180

ggacttgcct ggcctgcctg gacttgcctg gcctgcctgg acttgcctgg cctgcctgga      240

cttgcctggc ctgcctggac ttgcctggcc tgcctggact tgcctggcct gcctggactt      300

gcctggcctg cctggacttg cctgg                                            325


<210>  16
<211>  188
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa can be glycine or aspartic acid

<400>  16

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Xaa Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  17
<211>  189
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be Glutamine or lysine

<400>  17

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Xaa Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  18
<211>  189
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be glycine or valine

<400>  18

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Xaa Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  19
<211>  527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV minimal promoter (without the tetracycline operator)

<400>  19
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcaga                    527


<210>  20
<211>  1653
<212>  DNA
<213>  Artificial sequence

<220>
<223>  luciferase coding sequence

<400>  20
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatccgct ggaagatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtggac atcacttacg ctgagtactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgggcatt      360

tcgcagccta ccgtggtgtt cgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaagctcc caatcatcca aaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtgccag agtccttcga tagggacaag acaattgcac tgatcatgaa ctcctctgga      600

tctactggtc tgcctaaagg tgtcgctctg cctcatagaa ctgcctgcgt gagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttc tgaggagcct tcaggattac      840

aagattcaaa gtgcgctgct ggtgccaacc ctattctcct tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctggtggcgc tcccctctct      960

aaggaagtcg gggaagcggt tgccaagagg ttccatctgc caggtatcag gcaaggatat     1020

gggctcactg agactacatc agctattctg attacacccg agggggatga taaaccgggc     1080

gcggtcggta aagttgttcc attttttgaa gcgaaggttg tggatctgga taccgggaaa     1140

acgctgggcg ttaatcaaag aggcgaactg tgtgtgagag gtcctatgat tatgtccggt     1200

tatgtaaaca atccggaagc gaccaacgcc ttgattgaca aggatggatg gctacattct     1260

ggagacatag cttactggga cgaagacgaa cacttcttca tcgttgaccg cctgaagtct     1320

ctgattaagt acaaaggcta tcaggtggct cccgctgaat tggaatccat cttgctccaa     1380

caccccaaca tcttcgacgc aggtgtcgca ggtcttcccg acgatgacgc cggtgaactt     1440

cccgccgccg ttgttgtttt ggagcacgga aagacgatga cggaaaaaga gatcgtggat     1500

tacgtcgcca gtcaagtaac aaccgcgaaa aagttgcgcg gaggagttgt gtttgtggac     1560

gaagtaccga aaggtcttac cggaaaactc gacgcaagaa aaatcagaga gatcctcata     1620

aaggccaaga agggcggaaa gatcgccgtg taa                                  1653


<210>  21
<211>  52
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hind-Cher-Forward primer

<400>  21
cttttgcaaa aagcttccac catgggaatt cacgtgagca agggcgagga gg               52


<210>  22
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Xba-Maz-Reverse primer

<400>  22
ccgccccgac tctagactaa ccggtgccaa tcagtacgtt aattttggc                   49


<210>  23
<211>  4
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ETS domain

<400>  23
ggaw                                                                     4


<210>  24
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ToxI RNA repeated motif

<400>  24
aggtgatttg ctacctttaa gtgcagctag aaattc                                 36


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
cccaagcaat ggatgatttg a                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
ggcagaccag catgacagat t                                                 21


<210>  27
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
tgagcagatc atgaagacag gg                                                22


<210>  28
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  28
agagctggaa gtcgagtgt                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  29
tcaacgcaca gtacgagcg                                                    19


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  30
caggcaaatg tgcaatacca a                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  31
gcctataaga acgtggtggg c                                                 21


<210>  32
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  32
ccctcctacc tctggttctt acg                                               23


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  33
ccaggaggca ctcacagagc                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  34
ctcaacgtcg accccgataa                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  35
ccaccgcatc tctacattca                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  36
ggcattctgg gagcttcatc t                                                 21


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  37
gcggattagg gcttcctctt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  38
gctcgatcct ggatgaaacc                                                   20


<210>  39
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  39
gcaccttcac attcctctc                                                    19


<210>  40
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  40
gtaagggcag gagtcccatg                                                   20


<210>  41
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  41
ggttacagca ccatcagtag gtacag                                            26


<210>  42
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  42
cctcgttgct tttctgctca a                                                 21


<210>  43
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  43
ttgaatgtca gtcacttggg cat                                               23


<210>  44
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  44
gcccttggac ggcttttc                                                     18


<210>  45
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  45
acatctctgt cgtcgtcctc g                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  46
caagtctggc tcgttctcag t                                                 21


<210>  47
<211>  52
<212>  PRT
<213>  Escherichia coli

<400>  47

Met Lys Leu Pro Arg Ser Ser Leu Val Trp Cys Val Leu Ile Val Cys 
1               5                   10                  15      


Leu Thr Leu Leu Ile Phe Thr Tyr Leu Thr Arg Lys Ser Leu Cys Glu 
            20                  25                  30          


Ile Arg Tyr Arg Asp Gly His Arg Glu Val Ala Ala Phe Met Ala Tyr 
        35                  40                  45              


Glu Ser Gly Lys 
    50          


<210>  48
<211>  159
<212>  DNA
<213>  Escherichia coli

<400>  48
atgaaactac cacgaagttc ccttgtctgg tgtgtgttga tcgtgtgtct cacactgttg       60

atattcactt atctgacacg aaaatcgctg tgcgagattc gttacagaga cggacacagg      120

gaggtggcgg ctttcatggc ttacgaatcc ggtaagtag                             159


<210>  49
<211>  225
<212>  DNA
<213>  Escherichia coli

<400>  49
atgtggacta gacataggga tgcctcgtgg tggttaatga aaattaactt actacggggc       60

tatcttcttt ctgccacaca acacggcaac aaaccacctt cacgtcatga ggcagaaagc      120

ctcaagcgcc gggcacatca tagcccatat acctgcacgc tgaccacact cactttccct      180

gaaaataatc cgctcattca gaccgttcac gggaaatccg tgtga                      225


<210>  50
<211>  74
<212>  PRT
<213>  Escherichia coli

<400>  50

Met Trp Thr Arg His Arg Asp Ala Ser Trp Trp Leu Met Lys Ile Asn 
1               5                   10                  15      


Leu Leu Arg Gly Tyr Leu Leu Ser Ala Thr Gln His Gly Asn Lys Pro 
            20                  25                  30          


Pro Ser Arg His Glu Ala Glu Ser Leu Lys Arg Arg Ala His His Ser 
        35                  40                  45              


Pro Tyr Thr Cys Thr Leu Thr Thr Leu Thr Phe Pro Glu Asn Asn Pro 
    50                  55                  60                  


Leu Ile Gln Thr Val His Gly Lys Ser Val 
65                  70                  


<210>  51
<211>  111
<212>  PRT
<213>  Proteobacteria

<400>  51

Met Val Ser Arg Tyr Val Pro Asp Met Gly Asp Leu Ile Trp Val Asp 
1               5                   10                  15      


Phe Asp Pro Thr Lys Gly Ser Glu Gln Ala Gly His Arg Pro Ala Val 
            20                  25                  30          


Val Leu Ser Pro Phe Met Tyr Asn Asn Lys Thr Gly Met Cys Leu Cys 
        35                  40                  45              


Val Pro Cys Thr Thr Gln Ser Lys Gly Tyr Pro Phe Glu Val Val Leu 
    50                  55                  60                  


Ser Gly Gln Glu Arg Asp Gly Val Ala Leu Ala Asp Gln Val Lys Ser 
65                  70                  75                  80  


Ile Ala Trp Arg Ala Arg Gly Ala Thr Lys Lys Gly Thr Val Ala Pro 
                85                  90                  95      


Glu Glu Leu Gln Leu Ile Lys Ala Lys Ile Asn Val Leu Ile Gly 
            100                 105                 110     


<210>  52
<211>  82
<212>  PRT
<213>  Escherichia coli

<400>  52

Met Ile His Ser Ser Val Lys Arg Trp Gly Asn Ser Pro Ala Val Arg 
1               5                   10                  15      


Ile Pro Ala Thr Leu Met Gln Ala Leu Asn Leu Asn Ile Asp Asp Glu 
            20                  25                  30          


Val Lys Ile Asp Leu Val Asp Gly Lys Leu Ile Ile Glu Pro Val Arg 
        35                  40                  45              


Lys Glu Pro Val Phe Thr Leu Ala Glu Leu Val Asn Asp Ile Thr Pro 
    50                  55                  60                  


Glu Asn Leu His Glu Asn Ile Asp Trp Gly Glu Pro Lys Asp Lys Glu 
65                  70                  75                  80  


Val Trp 
        


<210>  53
<211>  8
<212>  DNA
<213>  Artificial sequence

<220>
<223>  E2F binding site

<400>  53
tttcccgc                                                                 8


