                         SEQUENCE LISTING

<110>  BRITISH COLUMBIA CANCER AGENCY BRANCH
 
<120>  RECOMBINANT ONCOLYTIC VIRUSES AND USES THEREOF

<130>  10006-016WO1

<140>  PCT/IB2016/052922
<141>  2016-05-19

<150>  62/163,918
<151>  2015-05-19

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  365
<212>  DNA
<213>  Mus musculus

<400>  1
gagaagcgct tcatccaccg ctgagagaca tcccgagcca accttccgga agcctcccca       60

tcagcaccat gaacccaagt gctgccgtca ttttctgcct catcctgctg ggtctgagtg      120

ggactcaagg gatccctctc gcaaggacgg tccgctgcaa ctgcatccat atcgatgacg      180

ggccagtgag aatgagggcc atagggaagc ttgaaatcat ccctgcgagc ctatcctgcc      240

cacgtgttga gatcattgcc acgatgaaaa agaatgatga gcagagatgt ctgaatccgg      300

aatctaagac catcaagaat ttaatgaaag cgtttagcca aaaaaggtct aaaagggctc      360

cttaa                                                                  365


<210>  2
<211>  98
<212>  PRT
<213>  Mus musculus

<400>  2

Met Asn Pro Ser Ala Ala Val Ile Phe Cys Leu Ile Leu Leu Gly Leu 
1               5                   10                  15      


Ser Gly Thr Gln Gly Ile Pro Leu Ala Arg Thr Val Arg Cys Asn Cys 
            20                  25                  30          


Ile His Ile Asp Asp Gly Pro Val Arg Met Arg Ala Ile Gly Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Leu Ser Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Asn Asp Glu Gln Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Thr Ile Lys Asn Leu Met Lys Ala Phe Ser Gln Lys Arg Ser Lys Arg 
                85                  90                  95      


Ala Pro 
        


<210>  3
<211>  1172
<212>  DNA
<213>  Homo sapiens

<400>  3
gagacattcc tcaattgctt agacatattc tgagcctaca gcagaggaac ctccagtctc       60

agcaccatga atcaaactgc gattctgatt tgctgcctta tctttctgac tctaagtggc      120

attcaaggag tacctctctc tagaaccgta cgctgtacct gcatcagcat tagtaatcaa      180

cctgttaatc caaggtcttt agaaaaactt gaaattattc ctgcaagcca attttgtcca      240

cgtgttgaga tcattgctac aatgaaaaag aagggtgaga agagatgtct gaatccagaa      300

tcgaaggcca tcaagaattt actgaaagca gttagcaagg aaatgtctaa aagatctcct      360

taaaaccaga ggggagcaaa atcgatgcag tgcttccaag gatggaccac acagaggctg      420

cctctcccat cacttcccta catggagtat atgtcaagcc ataattgttc ttagtttgca      480

gttacactaa aaggtgacca atgatggtca ccaaatcagc tgctactact cctgtaggaa      540

ggttaatgtt catcatccta agctattcag taataactct accctggcac tataatgtaa      600

gctctactga ggtgctatgt tcttagtgga tgttctgacc ctgcttcaaa tatttccctc      660

acctttccca tcttccaagg gtactaagga atctttctgc tttggggttt atcagaattc      720

tcagaatctc aaataactaa aaggtatgca atcaaatctg ctttttaaag aatgctcttt      780

acttcatgga cttccactgc catcctccca aggggcccaa attctttcag tggctaccta      840

catacaattc caaacacata caggaaggta gaaatatctg aaaatgtatg tgtaagtatt      900

cttatttaat gaaagactgt acaaagtata agtcttagat gtatatattt cctatattgt      960

tttcagtgta catggaataa catgtaatta agtactatgt atcaatgagt aacaggaaaa     1020

ttttaaaaat acagatagat atatgctctg catgttacat aagataaatg tgctgaatgg     1080

ttttcaaata aaaatgaggt actctcctgg aaatattaag aaagactatc taaatgttga     1140

aagatcaaaa ggttaataaa gtaattataa ct                                   1172


<210>  4
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  5
<211>  362
<212>  DNA
<213>  Mus musculus

<400>  5
gagctaaagg ttgaactcca cctccaggca gaatgaggct cagcacagca acgctgcttc       60

tcctcctggc cagctgcctc tctccaggcc acggtattct ggaagcccat tacacaaact      120

taaaatgtag gtgttctgga gtgatttcaa ctgttgtcgg tctaaacatc atagatcgga      180

ttcaagttac gccccctggg aatggctgcc ccaaaactga agttgtgatc tggaccaaga      240

tgaagaaagt tatatgtgtg aatcctcgtg ccaaatggtt acaaagatta ttaagacatg      300

tccaaagcaa aagtctgtct tcaactcccc aagctccagt gagtaagaga agagctgcct      360

ga                                                                     362


<210>  6
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  6

Met Arg Leu Ser Thr Ala Thr Leu Leu Leu Leu Leu Ala Ser Cys Leu 
1               5                   10                  15      


Ser Pro Gly His Gly Ile Leu Glu Ala His Tyr Thr Asn Leu Lys Cys 
            20                  25                  30          


Arg Cys Ser Gly Val Ile Ser Thr Val Val Gly Leu Asn Ile Ile Asp 
        35                  40                  45              


Arg Ile Gln Val Thr Pro Pro Gly Asn Gly Cys Pro Lys Thr Glu Val 
    50                  55                  60                  


Val Ile Trp Thr Lys Met Lys Lys Val Ile Cys Val Asn Pro Arg Ala 
65                  70                  75                  80  


Lys Trp Leu Gln Arg Leu Leu Arg His Val Gln Ser Lys Ser Leu Ser 
                85                  90                  95      


Ser Thr Pro Gln Ala Pro Val Ser Lys Arg Arg Ala Ala 
            100                 105                 


<210>  7
<211>  1219
<212>  DNA
<213>  Homo sapiens

<400>  7
gagaagatgt ttgaaaaaac tgactctgct aatgagcctg gactcagagc tcaagtctga       60

actctacctc cagacagaat gaagttcatc tcgacatctc tgcttctcat gctgctggtc      120

agcagcctct ctccagtcca aggtgttctg gaggtctatt acacaagctt gaggtgtaga      180

tgtgtccaag agagctcagt ctttatccct agacgcttca ttgatcgaat tcaaatcttg      240

ccccgtggga atggttgtcc aagaaaagaa atcatagtct ggaagaagaa caagtcaatt      300

gtgtgtgtgg accctcaagc tgaatggata caaagaatga tggaagtatt gagaaaaaga      360

agttcttcaa ctctaccagt tccagtgttt aagagaaaga ttccctgatg ctgatatttc      420

cactaagaac acctgcattc ttcccttatc cctgctctgg attttagttt tgtgcttagt      480

taaatctttt ccaggaaaaa gaacttcccc atacaaataa gcatgagact atgtaaaaat      540

aaccttgcag aagctgatgg ggcaaactca agcttcttca ctcacagcac cctatataca      600

cttggagttt gcattcttat tcatcaggga ggaaagtttc tttgaaaata gttattcagt      660

tataagtaat acaggattat tttgattata tacttgttgt ttaatgttta aaatttctta      720

gaaaacaatg gaatgagaat ttaagcctca aatttgaaca tgtggcttga attaagaaga      780

aaattatggc atatattaaa agcaggcttc tatgaaagac tcaaaaagct gcctgggagg      840

cagatggaac ttgagcctgt caagaggcaa aggaatccat gtagtagata tcctctgctt      900

aaaaactcac tacggaggag aattaagtcc tacttttaaa gaatttcttt ataaaattta      960

ctgtctaaga ttaatagcat tcgaagatcc ccagacttca tagaatactc agggaaagca     1020

tttaaagggt gatgtacaca tgtatccttt cacacatttg ccttgacaaa cttctttcac     1080

tcacatcttt ttcactgact ttttttgtgg ggggcggggc cggggggact ctggtatcta     1140

attctttaat gattcctata aatctaatga cattcaataa agttgagcaa acattttact     1200

taaaaaaaaa aaaaaaaaa                                                  1219


<210>  8
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  9
<211>  5627
<212>  DNA
<213>  Mus musculus

<400>  9
gcactttcac tctcggtcca cctcggtgtc ctcttgctgt ccagctctgc agcctccggc       60

gcgccctccc gcccacgcca tggacgccaa ggtcgtcgcc gtgctggccc tggtgctggc      120

cgcgctctgc atcagtgacg gtaaaccagt cagcctgagc taccgatgcc cctgccggtt      180

cttcgagagc cacatcgcca gagccaacgt caagcatctg aaaatcctca acactccaaa      240

ctgtgccctt cagattgttg cacggctgaa gaacaacaac agacaagtgt gcattgaccc      300

gaaattaaag tggatccaag agtacctgga gaaagcttta aacaaggggc gcagagaaga      360

aaaagtgggg aaaaaagaaa agataggaaa aaagaagcga cagaagaaga gaaaggctgc      420

ccagaaaagg aaaaactagt tccccgcttc ctgccgatgg accgcagtgc gctctgctct      480

ggcgctttgt aactcgctcc tccctcttcg ggggcagacc ccacactccg ggcaggtgct      540

caaacctgac ggtaaactct tccctcttcg ggggcagacc ccataccccg gggcgggtgc      600

ttaggctttc ctgccctggt ggccacacca gctgctgtat ttatgtgctt cataaggccc      660

tgctctgtct gctaaagcta tgaagaaaga tgtgcagaga ctggggtgga gactaagcca      720

aagaggagct gcctagcctg gcagcattgc cccgagctga gcccccttgg ccaggacttc      780

acaaggctca cacctacaat cccatgaagg ccagggtggt ctgcttagcc aggaaagggc      840

aagtgccttc ccctcggcca cactgcccct tgtggccttc tcgggacatg tggtaactga      900

cttgctctca ggcccacccg cagcttttcc aaatacctgc agccttcagc cctgctgccc      960

tgcctgtggg agcagctttg actccagtcc agaagggttt ctgcagactg tgttgggtga     1020

gacgcagaaa ggatgaaatc tcagaacaca tgtcagctgc ttctcaggaa atcttttctt     1080

tggacaattc actttagagt ctttaaacgg gtctctcgtg gggaggatag atgtgctctg     1140

gaactttctg aaggaccagc agcttcaggg actcttagtc tgtccttccc cacttttggt     1200

cccaacatcc ctgggatggt gtgctgtctg ggcaccacgg tctccatcct cactcctgag     1260

agatttctgc cttctgtgag ttgggttaaa gctctggaat tatctactat cccaatccac     1320

taccctcacc tggcaatatt tgtctgtttt tgtttgtttg tttgtttgtt tttgtctttt     1380

gccagtttga attagaaggc aaggctctga ttttagtagt gttttggaaa aggacttttt     1440

tcttcacctt cctctttgcc tcatgtgtac acacacacac acatcttgta ccccagacct     1500

ctgggtataa ttttcataat tggtgcagaa agaagaaatg atctgaagat gtgttaaatg     1560

gattgcaggg gaaggaaggc ccagggccct gtgtgtcatg ccctcttggg ttcctaagtt     1620

ctatgttcct tagaggttct agcattaaac agataaagcc cttcatggtc ctggctgagg     1680

aagagtcttg ctagggggat tcagggaaga cccgtgttac cagctcttac cctttatctg     1740

gacagctctc ctaccctgta tcttctcctc agatctgagg atagcaggct ggactattgg     1800

tgggcacctt tcaagcccag ggctactgtt tgtcctgtgg cagccggcta cagtctcgtc     1860

tgagtggcct catctggacc cttcctgtta ttaataaaac gcttctggag gccagatctg     1920

tgctcaagcc atagttctgc ttagaaaggg atgccccacc cttaccggac actgggaaga     1980

actgttggcc cctagaaacc aaaggccaaa ctgaggctgc cctgagttgg aagaccactt     2040

tctgaaatgc ccatggactc tgcctcccaa ccattcgtct ctcactccta gcagagctgt     2100

ctgtgcagac tgtttcttag gaggcacagc aagctccagg gaaccctctg tgcttatgaa     2160

gctcgtctgg tgggcaaccc cagcccactg gacagagtcc tcatggaaat gcctgggaag     2220

ctgatttcat ctaaggatgg gttgaagtag gatgtgctcc tgcgacttct caggcaggtg     2280

agaggggtag tccttacact gtctagcata aacgccttcc ggaaggacct gcagctccag     2340

agaccacctc ctgagcacca agacctcttc tggtggtgtg gaaccagcca agagatttca     2400

aggaagagtg attatttgat gaatgctatg ggaatggcct cttctcttgg agttctgagg     2460

cctggggatg cccaggaaca ctgggcacct gctgctgtta gggccaatgc atagtctcag     2520

caccggtgtc ctaaggttaa ggcggtgcgc cttgtcatgt gctccttgta ccatgccatc     2580

tgtgccagtg tgtgtctgcc tcaccctgtg cttgacatgt tcacccatct tctctgcttc     2640

ccgccaccat ccagatcctc agcggccgcc ccggctgtgc ccttccctgc tctcccgctc     2700

tctcaggcct cggaaggaag atcggtggct gcgagctgaa ctaaggagta gggcctgtgg     2760

ctcagcgcta ggccacgcac gcagcatccc aggcatgtgg tgagaaactg ccttaatgtg     2820

tctcctctgt tcttgtcaac aggaggctca agatgtgaga ggtgtgagtc agacgcccga     2880

ggaacttaca ggaggagcct aggtctgaag tcagtgttag ggaagggccc atagccactt     2940

cctctgctcc tgagcagggc tgaagccgtt tgcaagggac ttgctttgca cagttttgct     3000

gtactttcac attttattat gtagcaagat acatggtgat tttttttttt ttcatttagc     3060

ctgattttcc aacgtcattg gtgacaggcc aaggccacta tgttatttcc tttgttctgg     3120

tatccttccc ttggaggacc ttctctgagt agtggctccc caggtttgtc ctttgagctg     3180

aggcaggagg ctcacccatt cttctgaata ggaactgggt gttcccaccc cccaaggact     3240

gcagggcttt cccaagctga ggcaggaacg tgaggccagg gaagagtgag cttcaccctc     3300

atcccacgct gtcctcctca acccaccatg ctcatcattc tgtctcatcc atccatccat     3360

ccatccattc atcgccatgt gtccgcaaga ctgtctccat gaccctgaaa aaggactctc     3420

gagatgaaat cctttattca aatgggacag caagaaggaa aagccaatgt ctggtgtctc     3480

tccccccgcc cctaccctgc gcgcatctat gtcttgtttg gaatattgtc tcttcaaccc     3540

cctgttcatg tccttctcac tcatgatcga tgtcttgtct gtgcactgtc tctaacccaa     3600

atgcaaaggc tgagtgtgag gtgatggccc cgaggtccag gttgtagtca tggaaagagc     3660

cctgctgtct cccttctcag ggggcccatt ttagacacac aaagcccaaa gaaaggtggt     3720

ttgcaacagt gcttagctcg agcctccata tttccataac tgttagctta aaactgtggg     3780

gttttacctt cctggaacca aatgcattct tctgttgagg agtaacaggt ctcaattctt     3840

ttcaattaat tttaaaagtc aatcactaag agcatcggct ttgggccctg atgggcaggc     3900

atttccctgg aaagggggtg aactacctac ctctcctcaa gacagccgaa gggtgggatt     3960

ggtgccgctc tgggaagcgt ggccccagga gttttgtcct ctgcagtttt taatgcaagt     4020

tcactgccac tttgacaaaa gcccaattag aagccagtct ctagttcctt aaacaaaaca     4080

gacagagtaa ggaaaggaag gagggtggca gccagctggc tggacactcg agaaagacgg     4140

ggaagtaagc tacagaaaga tagtcttcaa aaacaggtgt ttgagagtga atactctgta     4200

gaattgttag tggggtgtgt gtggtggtgg tggggggatt tctacaaaat agtcctttaa     4260

gttgagttta cagcagatga aaaatccaac cagcaaaatt ttgatcaaat ttgaacaaaa     4320

acccaaaaac ctaaaactgt tgagcaggtt gcgatgagga gcacagggct agctgcagag     4380

ctggatcctc aggaggatag cgaattattt tcaaccctgg aatagaaacc acacactggc     4440

ttgctgtgca ccagccactt tgcatctaat ccaagctttg aagggtgttg cttgggagga     4500

aacaaataca gccttccatc ttcactccag ttagggatcc tttcaaagtc tccttcacag     4560

tgaggaaaaa gagaagggta gaaactttag ggagccggat ttgtgtatca attcctccgc     4620

tgacagtcag tttctagatg gagacagcct gcttaaagca aatccgaatt taaataggac     4680

atttacatcg gaaaagtctc tccctacctt aatcccccat tctcttgctt tcaaaataca     4740

agcacagcag tccttgaatg gctgttgacc cagggcacct agctgtccct gctggtcctg     4800

gggctgccag aattcccttg ggcgccaagc aacctgccag gtagccagtc cctctgttac     4860

aagcctttgc atctggatag ggaaaggggt ggagacatac agtctgcttt gtgttgaaac     4920

ccagatttgt accctgtgtt tatacactgc tgctggctcc cgaggacagt gggactttag     4980

caaggaagtg cagccgaggg gtaaagagcc ctctggttca ttgcctgatc ggctttgaga     5040

gagggtttgg agggcaaggg gctgcattcc tctgagggac ttggcctgag gcctttcggg     5100

cctctccagt gggttctgtt tatcctctca tgggtgatta tctcagtggt gtcaccaggg     5160

gcttcctccc agaagtcagt catccccagg ccgtgcaccc ttttcagctg gatgagagcc     5220

agggatgcat tctctccaaa cagctaccct ggcccatttt aaggtaatct cattcttcaa     5280

aatgttccat agaatcctcc aaattccccc agcagacttc taccctcgcc aagttcccaa     5340

aacccactca gcaaagttgc caacctcgac gggctagcag tgtctaagca gcgatgggtt     5400

cagtgttgtg tgtggtgaat actgtatttt gtttcagttc tgtctcccag ataatgtgaa     5460

aacggtccag gagaaggcag cttcctatat gcagcgtgtg ctttcttatt cttattttta     5520

atatatgaca gttatttgag aagccatttc tactttgaag tcattatcga tgaaagtgat     5580

gtatcttcac ctaccatttt cctaataaag ttctgtattc aaatata                   5627


<210>  10
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  10

Met Asp Ala Lys Val Val Ala Val Leu Ala Leu Val Leu Ala Ala Leu 
1               5                   10                  15      


Cys Ile Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Ile Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Gly Arg Arg Glu Glu Lys Val 
                85                  90                  95      


Gly Lys Lys Glu Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys 
            100                 105                 110         


Ala Ala Gln Lys Arg Lys Asn 
        115                 


<210>  11
<211>  3549
<212>  DNA
<213>  Homo sapiens

<400>  11
gccgcacttt cactctccgt cagccgcatt gcccgctcgg cgtccggccc ccgacccgcg       60

ctcgtccgcc cgcccgcccg cccgcccgcg ccatgaacgc caaggtcgtg gtcgtgctgg      120

tcctcgtgct gaccgcgctc tgcctcagcg acgggaagcc cgtcagcctg agctacagat      180

gcccatgccg attcttcgaa agccatgttg ccagagccaa cgtcaagcat ctcaaaattc      240

tcaacactcc aaactgtgcc cttcagattg tagcccggct gaagaacaac aacagacaag      300

tgtgcattga cccgaagcta aagtggattc aggagtacct ggagaaagct ttaaacaaga      360

ggttcaagat gtgagagggt cagacgcctg aggaaccctt acagtaggag cccagctctg      420

aaaccagtgt tagggaaggg cctgccacag cctcccctgc cagggcaggg ccccaggcat      480

tgccaagggc tttgttttgc acactttgcc atattttcac catttgatta tgtagcaaaa      540

tacatgacat ttatttttca tttagtttga ttattcagtg tcactggcga cacgtagcag      600

cttagactaa ggccattatt gtacttgcct tattagagtg tctttccacg gagccactcc      660

tctgactcag ggctcctggg ttttgtattc tctgagctgt gcaggtgggg agactgggct      720

gagggagcct ggccccatgg tcagccctag ggtggagagc caccaagagg gacgcctggg      780

ggtgccagga ccagtcaacc tgggcaaagc ctagtgaagg cttctctctg tgggatggga      840

tggtggaggg ccacatggga ggctcacccc cttctccatc cacatgggag ccgggtctgc      900

ctcttctggg agggcagcag ggctaccctg agctgaggca gcagtgtgag gccagggcag      960

agtgagaccc agccctcatc ccgagcacct ccacatcctc cacgttctgc tcatcattct     1020

ctgtctcatc catcatcatg tgtgtccacg actgtctcca tggccccgca aaaggactct     1080

caggaccaaa gctttcatgt aaactgtgca ccaagcagga aatgaaaatg tcttgtgtta     1140

cctgaaaaca ctgtgcacat ctgtgtcttg tttggaatat tgtccattgt ccaatcctat     1200

gtttttgttc aaagccagcg tcctcctctg tgaccaatgt cttgatgcat gcactgttcc     1260

ccctgtgcag ccgctgagcg aggagatgct ccttgggccc tttgagtgca gtcctgatca     1320

gagccgtggt cctttggggt gaactacctt ggttccccca ctgatcacaa aaacatggtg     1380

ggtccatggg cagagcccaa gggaattcgg tgtgcaccag ggttgacccc agaggattgc     1440

tgccccatca gtgctccctc acatgtcagt accttcaaac tagggccaag cccagcactg     1500

cttgaggaaa acaagcattc acaacttgtt tttggttttt aaaacccagt ccacaaaata     1560

accaatcctg gacatgaaga ttctttccca attcacatct aacctcatct tcttcaccat     1620

ttggcaatgc catcatctcc tgccttcctc ctgggccctc tctgctctgc gtgtcacctg     1680

tgcttcgggc ccttcccaca ggacatttct ctaagagaac aatgtgctat gtgaagagta     1740

agtcaacctg cctgacattt ggagtgttcc ccttccactg agggcagtcg atagagctgt     1800

attaagccac ttaaaatgtt cacttttgac aaaggcaagc acttgtgggt ttttgttttg     1860

tttttcattc agtcttacga atacttttgc cctttgatta aagactccag ttaaaaaaaa     1920

ttttaatgaa gaaagtggaa aacaaggaag tcaaagcaag gaaactatgt aacatgtagg     1980

aagtaggaag taaattatag tgatgtaatc ttgaattgta actgttcttg aatttaataa     2040

tctgtagggt aattagtaac atgtgttaag tattttcata agtatttcaa attggagctt     2100

catggcagaa ggcaaaccca tcaacaaaaa ttgtccctta aacaaaaatt aaaatcctca     2160

atccagctat gttatattga aaaaatagag cctgagggat ctttactagt tataaagata     2220

cagaactctt tcaaaacctt ttgaaattaa cctctcacta taccagtata attgagtttt     2280

cagtggggca gtcattatcc aggtaatcca agatatttta aaatctgtca cgtagaactt     2340

ggatgtacct gcccccaatc catgaaccaa gaccattgaa ttcttggttg aggaaacaaa     2400

catgacccta aatcttgact acagtcagga aaggaatcat ttctatttct cctccatggg     2460

agaaaataga taagagtaga aactgcaggg aaaattattt gcataacaat tcctctacta     2520

acaatcagct ccttcctgga gactgcccag ctaaagcaat atgcatttaa atacagtctt     2580

ccatttgcaa gggaaaagtc tcttgtaatc cgaatctctt tttgctttcg aactgctagt     2640

caagtgcgtc cacgagctgt ttactaggga tccctcatct gtccctccgg gacctggtgc     2700

tgcctctacc tgacactccc ttgggctccc tgtaacctct tcagaggccc tcgctgccag     2760

ctctgtatca ggacccagag gaaggggcca gaggctcgtt gactggctgt gtgttgggat     2820

tgagtctgtg ccacgtgttt gtgctgtggt gtgtccccct ctgtccaggc actgagatac     2880

cagcgaggag gctccagagg gcactctgct tgttattaga gattacctcc tgagaaaaaa     2940

ggttccgctt ggagcagagg ggctgaatag cagaaggttg cacctccccc aaccttagat     3000

gttctaagtc tttccattgg atctcattgg acccttccat ggtgtgatcg tctgactggt     3060

gttatcaccg tgggctccct gactgggagt tgatcgcctt tcccaggtgc tacacccttt     3120

tccagctgga tgagaatttg agtgctctga tccctctaca gagcttccct gactcattct     3180

gaaggagccc cattcctggg aaatattccc tagaaacttc caaatcccct aagcagacca     3240

ctgataaaac catgtagaaa atttgttatt ttgcaacctc gctggactct cagtctctga     3300

gcagtgaatg attcagtgtt aaatgtgatg aatactgtat tttgtattgt ttcaattgca     3360

tctcccagat aatgtgaaaa tggtccagga gaaggccaat tcctatacgc agcgtgcttt     3420

aaaaaataaa taagaaacaa ctctttgaga aacaacaatt tctactttga agtcatacca     3480

atgaaaaaat gtatatgcac ttataatttt cctaataaag ttctgtactc aaatgtagcc     3540

accaacagt                                                             3549


<210>  12
<211>  3560
<212>  DNA
<213>  Homo sapiens

<400>  12
gccgcacttt cactctccgt cagccgcatt gcccgctcgg cgtccggccc ccgacccgcg       60

ctcgtccgcc cgcccgcccg cccgcccgcg ccatgaacgc caaggtcgtg gtcgtgctgg      120

tcctcgtgct gaccgcgctc tgcctcagcg acgggaagcc cgtcagcctg agctacagat      180

gcccatgccg attcttcgaa agccatgttg ccagagccaa cgtcaagcat ctcaaaattc      240

tcaacactcc aaactgtgcc cttcagattg tagcccggct gaagaacaac aacagacaag      300

tgtgcattga cccgaagcta aagtggattc aggagtacct ggagaaagct ttaaacaaga      360

ggttcaagat gtgagagggt cagacgcctg aggaaccctt acagtaggag cccagctctg      420

aaaccagtgt tagggaaggg cctgccacag cctcccctgc cagggcaggg ccccaggcat      480

tgccaagggc tttgttttgc acactttgcc atattttcac catttgatta tgtagcaaaa      540

tacatgacat ttatttttca tttagtttga ttattcagtg tcactggcga cacgtagcag      600

cttagactaa ggccattatt gtacttgcct tattagagtg tctttccacg gagccactcc      660

tctgactcag ggctcctggg ttttgtattc tctgagctgt gcaggtgggg agactgggct      720

gagggagcct ggccccatgg tcagccctag ggtggagagc caccaagagg gacgcctggg      780

ggtgccagga ccagtcaacc tgggcaaagc ctagtgaagg cttctctctg tgggatggga      840

tggtggaggg ccacatggga ggctcacccc cttctccatc cacatgggag ccgggtctgc      900

ctcttctggg agggcagcag ggctaccctg agctgaggca gcagtgtgag gccagggcag      960

agtgagaccc agccctcatc ccgagcacct ccacatcctc cacgttctgc tcatcattct     1020

ctgtctcatc catcatcatg tgtgtccacg actgtctcca tggccccgca aaaggactct     1080

caggaccaaa gctttcatgt aaactgtgca ccaagcagga aatgaaaatg tcttgtgtta     1140

cctgaaaaca ctgtgcacat ctgtgtcttg tttggaatat tgtccattgt ccaatcctat     1200

gtttttgttc aaagccagcg tcctcctctg tgaccaatgt cttgatgcat gcactgttcc     1260

ccctgtgcag ccgctgagcg aggagatgct ccttgggccc tttgagtgca gtcctgatca     1320

gagccgtggt cctttggggt gaactacctt ggttccccca ctgatcacaa aaacatggtg     1380

ggtccatggg cagagcccaa gggaattcgg tgtgcaccag ggttgacccc agaggattgc     1440

tgccccatca gtgctccctc acatgtcagt accttcaaac tagggccaag cccagcactg     1500

cttgaggaaa acaagcattc acaacttgtt tttggttttt aaaacccagt ccacaaaata     1560

accaatcctg gacatgaaga ttctttccca attcacatct aacctcatct tcttcaccat     1620

ttggcaatgc catcatctcc tgccttcctc ctgggccctc tctgctctgc gtgtcacctg     1680

tgcttcgggc ccttcccaca ggacatttct ctaagagaac aatgtgctat gtgaagagta     1740

agtcaacctg cctgacattt ggagtgttcc ccttccactg agggcagtcg atagagctgt     1800

attaagccac ttaaaatgtt cacttttgac aaaggcaagc acttgtgggt ttttgttttg     1860

tttttcattc agtcttacga atacttttgc cctttgatta aagactccag ttaaaaaaaa     1920

ttttaatgaa gaaagtggaa aacaaggaag tcaaagcaag gaaactatgt aacatgtagg     1980

aagtaggaag taaattatag tgatgtaatc ttgaattgta actgttcttg aatttaataa     2040

tctgtagggt aattagtaac atgtgttaag tattttcata agtatttcaa attggagctt     2100

catggcagaa ggcaaaccca tcaacaaaaa ttgtccctta aacaaaaatt aaaatcctca     2160

atccagctat gttatattga aaaaatagag cctgagggat ctttactagt tataaagata     2220

cagaactctt tcaaaacctt ttgaaattaa cctctcacta taccagtata attgagtttt     2280

cagtggggca gtcattatcc aggtaatcca agatatttta aaatctgtca cgtagaactt     2340

ggatgtacct gcccccaatc catgaaccaa gaccattgaa ttcttggttg aggaaacaaa     2400

catgacccta aatcttgact acagtcagga aaggaatcat ttctatttct cctccatggg     2460

agaaaataga taagagtaga aactgcaggg aaaattattt gcataacaat tcctctacta     2520

acaatcagct ccttcctgga gactgcccag ctaaagcaat atgcatttaa atacagtctt     2580

ccatttgcaa gggaaaagtc tcttgtaatc cgaatctctt tttgctttcg aactgctagt     2640

caagtgcgtc cacgagctgt ttactaggga tccctcatct gtccctccgg gacctggtgc     2700

tgcctctacc tgacactccc ttgggctccc tgtaacctct tcagaggccc tcgctgccag     2760

ctctgtatca ggacccagag gaaggggcca gaggctcgtt gactggctgt gtgttgggat     2820

tgagtctgtg ccacgtgttt gtgctgtggt gtgtccccct ctgtccaggc actgagatac     2880

cagcgaggag gctccagagg gcactctgct tgttattaga gattacctcc tgagaaaaaa     2940

ggttccgctt ggagcagagg ggctgaatag cagaaggttg cacctccccc aaccttagat     3000

gttctaagtc tttccattgg atctcattgg acccttccat ggtgtgatcg tctgactggt     3060

gttatcaccg tgggctccct gactgggagt tgatcgcctt tcccaggtgc tacacccttt     3120

tccagctgga tgagaatttg agtgctctga tccctctaca gagcttccct gactcattct     3180

gaaggagccc cattcctggg aaatattccc tagaaacttc caaatcccct aagcagacca     3240

ctgataaaac catgtagaaa atttgttatt ttgcaacctc gctggactct cagtctctga     3300

gcagtgaatg attcagtgtt aaatgtgatg aatactgtat tttgtattgt ttcaattgca     3360

tctcccagat aatgtgaaaa tggtccagga gaaggccaat tcctatacgc agcgtgcttt     3420

aaaaaataaa taagaaacaa ctctttgaga aacaacaatt tctactttga agtcatacca     3480

atgaaaaaat gtatatgcac ttataatttt cctaataaag ttctgtactc aaatgtagcc     3540

accaaaaaaa aaaaaaaaaa                                                 3560


<210>  13
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210>  14
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys 
                85                  


<210>  15
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Gly Arg Arg Glu Glu Lys Val 
                85                  90                  95      


Gly Lys Lys Glu Lys Ile Gly Lys Lys Lys Arg Gln Lys Lys Arg Lys 
            100                 105                 110         


Ala Ala Gln Lys Arg Lys Asn 
        115                 


<210>  16
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Asn Leu Ile Ser Ala Ala Pro Ala 
                85                  90                  95      


Gly Lys Arg Val Ile Ala Gly Ala Arg Ala Leu His Pro Ser Pro Pro 
            100                 105                 110         


Arg Ala Cys Pro Thr Ala Arg Ala Leu Cys Glu Ile Arg Leu Trp Pro 
        115                 120                 125             


Pro Pro Glu Trp Ser Trp Pro Ser Pro Gly Asp Val 
    130                 135                 140 


<210>  17
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Tyr Cys Thr Cys Leu Ile Arg Val Ser Phe 
        35                  40                  45              


His Gly Ala Thr Pro Leu Thr Gln Gly Ser Trp Val Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Cys Ala Gly Gly Glu Thr Gly Leu Arg Glu Pro Gly Pro Met Val 
65                  70                  75                  80  


Ser Pro Arg Val Glu Ser His Gln Glu Gly Arg Leu Gly Val Pro Gly 
                85                  90                  95      


Pro Val Asn Leu Gly Lys Ala 
            100             


<210>  18
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic Vaccinia Virus early/late promoter

<400>  18
aaaaattgaa attttatttt ttttttttgg aatataaata                             40


<210>  19
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VSV_CXCL13_left

<400>  19
taagcactcg aggagctaaa ggttgaactc cac                                    33


<210>  20
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VSV_CXCL13_right

<400>  20
tgcttagcta gctcaggcag ctcttctctt act                                    33


<210>  21
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VSV_CXCL10_left

<400>  21
taagcactcg aggagaagcg cttcatccac cg                                     32


<210>  22
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VSV_CXCL10_right

<400>  22
tgcttagcta gcttaaggag cccttttaga cct                                    33


<210>  23
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VV_CXCL13_left

<400>  23
gatccaacta gtaaaaattg aaattttatt tttttttttt ggaatataaa tagagctaaa       60

ggttgaactc cac                                                          73


<210>  24
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VV_CXCL13_right

<400>  24
tgcttaacta gttcaggcag ctcttctctt act                                    33


<210>  25
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VV_CXCL10_left

<400>  25
gatccaacta gtaaaaattg aaattttatt tttttttttt ggaatataaa tagagaagcg       60

cttcatccac cg                                                           72


<210>  26
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VV_CXCL10_right

<400>  26
tgcttaacta gtttaaggag cccttttaga cct                                    33


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VV_TK_Fwd

<400>  27
atgaacggcg gacatattca gt                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer VV_TK_Rev

<400>  28
gagtcgatgt aacactttct ac                                                22


