                         SEQUENCE LISTING

<110>  Boreal Genomics, Inc.
 
<120>  METHOD FOR ISOLATING TARGET NUCLEIC ACID

<130>  BRL-017/01WO 30249/68

<140>  PCT/IB2016/000796
<141>  2016-05-19

<150>  US 62/164,247
<151>  2015-05-20

<150>  US 62/291,222
<151>  2016-02-04

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  853
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Ser Thr Pro Glu Asn Phe Asp Ala His Thr Pro Met Met Gln Gln 
1               5                   10                  15      


Tyr Leu Lys Leu Lys Ala Gln His Pro Glu Ile Leu Leu Phe Tyr Arg 
            20                  25                  30          


Met Gly Asp Phe Tyr Glu Leu Phe Tyr Asp Asp Ala Lys Arg Ala Ser 
        35                  40                  45              


Gln Leu Leu Asp Ile Ser Leu Thr Lys Arg Gly Ala Ser Ala Gly Glu 
    50                  55                  60                  


Pro Ile Pro Met Ala Gly Ile Pro Tyr His Ala Val Glu Asn Tyr Leu 
65                  70                  75                  80  


Ala Lys Leu Val Asn Gln Gly Glu Ser Val Ala Ile Cys Glu Gln Ile 
                85                  90                  95      


Gly Asp Pro Ala Thr Ser Lys Gly Pro Val Glu Arg Lys Val Val Arg 
            100                 105                 110         


Ile Val Thr Pro Gly Thr Ile Ser Asp Glu Ala Leu Leu Gln Glu Arg 
        115                 120                 125             


Gln Asp Asn Leu Leu Ala Ala Ile Trp Gln Asp Ser Lys Gly Phe Gly 
    130                 135                 140                 


Tyr Ala Thr Leu Asp Ile Ser Ser Gly Arg Phe Arg Leu Ser Glu Pro 
145                 150                 155                 160 


Ala Asp Arg Glu Thr Met Ala Ala Glu Leu Gln Arg Thr Asn Pro Ala 
                165                 170                 175     


Glu Leu Leu Tyr Ala Glu Asp Phe Ala Glu Met Ser Leu Ile Glu Gly 
            180                 185                 190         


Arg Arg Gly Leu Arg Arg Arg Pro Leu Trp Glu Phe Glu Ile Asp Thr 
        195                 200                 205             


Ala Arg Gln Gln Leu Asn Leu Gln Phe Gly Thr Arg Asp Leu Val Gly 
    210                 215                 220                 


Phe Gly Val Glu Asn Ala Pro Arg Gly Leu Cys Ala Ala Gly Cys Leu 
225                 230                 235                 240 


Leu Gln Tyr Ala Lys Asp Thr Gln Arg Thr Thr Leu Pro His Ile Arg 
                245                 250                 255     


Ser Ile Thr Met Glu Arg Gln Gln Asp Ser Ile Ile Met Asp Ala Ala 
            260                 265                 270         


Thr Arg Arg Asn Leu Glu Ile Thr Gln Asn Leu Ala Gly Gly Ala Glu 
        275                 280                 285             


Asn Thr Leu Ala Ser Val Leu Asp Cys Thr Val Thr Pro Met Gly Ser 
    290                 295                 300                 


Arg Met Leu Lys Arg Trp Leu His Met Pro Val Arg Asp Thr Arg Val 
305                 310                 315                 320 


Leu Leu Glu Arg Gln Gln Thr Ile Gly Ala Leu Gln Asp Phe Thr Ala 
                325                 330                 335     


Glu Leu Gln Pro Val Leu Arg Gln Val Gly Asp Leu Glu Arg Ile Leu 
            340                 345                 350         


Ala Arg Leu Ala Leu Arg Thr Ala Arg Pro Arg Asp Leu Ala Arg Met 
        355                 360                 365             


Arg His Ala Phe Gln Gln Leu Pro Glu Leu Arg Ala Gln Leu Glu Asn 
    370                 375                 380                 


Val Asp Ser Ala Pro Val Gln Ala Leu Arg Glu Lys Met Gly Glu Phe 
385                 390                 395                 400 


Ala Glu Leu Arg Asp Leu Leu Glu Arg Ala Ile Ile Asp Thr Pro Pro 
                405                 410                 415     


Val Leu Val Arg Asp Gly Gly Val Ile Ala Ser Gly Tyr Asn Glu Glu 
            420                 425                 430         


Leu Asp Glu Trp Arg Ala Leu Ala Asp Gly Ala Thr Asp Tyr Leu Glu 
        435                 440                 445             


Arg Leu Glu Val Arg Glu Arg Glu Arg Thr Gly Leu Asp Thr Leu Lys 
    450                 455                 460                 


Val Gly Phe Asn Ala Val His Gly Tyr Tyr Ile Gln Ile Ser Arg Gly 
465                 470                 475                 480 


Gln Ser His Leu Ala Pro Ile Asn Tyr Met Arg Arg Gln Thr Leu Lys 
                485                 490                 495     


Asn Ala Glu Arg Tyr Ile Ile Pro Glu Leu Lys Glu Tyr Glu Asp Lys 
            500                 505                 510         


Val Leu Thr Ser Lys Gly Lys Ala Leu Ala Leu Glu Lys Gln Leu Tyr 
        515                 520                 525             


Glu Glu Leu Phe Asp Leu Leu Leu Pro His Leu Glu Ala Leu Gln Gln 
    530                 535                 540                 


Ser Ala Ser Ala Leu Ala Glu Leu Asp Val Leu Val Asn Leu Ala Glu 
545                 550                 555                 560 


Arg Ala Tyr Thr Leu Asn Tyr Thr Cys Pro Thr Phe Ile Asp Lys Pro 
                565                 570                 575     


Gly Ile Arg Ile Thr Glu Gly Arg His Pro Val Val Glu Gln Val Leu 
            580                 585                 590         


Asn Glu Pro Phe Ile Ala Asn Pro Leu Asn Leu Ser Pro Gln Arg Arg 
        595                 600                 605             


Met Leu Ile Ile Thr Gly Pro Asn Met Gly Gly Lys Ser Thr Tyr Met 
    610                 615                 620                 


Arg Gln Thr Ala Leu Ile Ala Leu Met Ala Tyr Ile Gly Ser Tyr Val 
625                 630                 635                 640 


Pro Ala Gln Lys Val Glu Ile Gly Pro Ile Asp Arg Ile Phe Thr Arg 
                645                 650                 655     


Val Gly Ala Ala Asp Asp Leu Ala Ser Gly Arg Ser Thr Phe Met Val 
            660                 665                 670         


Glu Met Thr Glu Thr Ala Asn Ile Leu His Asn Ala Thr Glu Tyr Ser 
        675                 680                 685             


Leu Val Leu Met Asp Glu Ile Gly Arg Gly Thr Ser Thr Tyr Asp Gly 
    690                 695                 700                 


Leu Ser Leu Ala Trp Ala Cys Ala Glu Asn Leu Ala Asn Lys Ile Lys 
705                 710                 715                 720 


Ala Leu Thr Leu Phe Ala Thr His Tyr Phe Glu Leu Thr Gln Leu Pro 
                725                 730                 735     


Glu Lys Met Glu Gly Val Ala Asn Val His Leu Asp Ala Leu Glu His 
            740                 745                 750         


Gly Asp Thr Ile Ala Phe Met His Ser Val Gln Asp Gly Ala Ala Ser 
        755                 760                 765             


Lys Ser Tyr Gly Leu Ala Val Ala Ala Leu Ala Gly Val Pro Lys Glu 
    770                 775                 780                 


Val Ile Lys Arg Ala Arg Gln Lys Leu Arg Glu Leu Glu Ser Ile Ser 
785                 790                 795                 800 


Pro Asn Ala Ala Ala Thr Gln Val Asp Gly Thr Gln Met Ser Leu Leu 
                805                 810                 815     


Ser Val Pro Glu Glu Thr Ser Pro Ala Val Glu Ala Leu Glu Asn Leu 
            820                 825                 830         


Asp Pro Asp Ser Leu Thr Pro Arg Gln Ala Leu Glu Trp Ile Tyr Arg 
        835                 840                 845             


Leu Lys Ser Leu Val 
    850             


<210>  2
<211>  1360
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala 
1               5                   10                  15      


Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly 
            20                  25                  30          


Arg Ala Ala Ala Ala Pro Glu Ala Ser Pro Ser Pro Gly Gly Asp Ala 
        35                  40                  45              


Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala 
    50                  55                  60                  


Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val 
65                  70                  75                  80  


Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val 
                85                  90                  95      


Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn 
            100                 105                 110         


His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg 
        115                 120                 125             


Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser 
    130                 135                 140                 


Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln 
145                 150                 155                 160 


Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met 
                165                 170                 175     


Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu 
            180                 185                 190         


Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met 
        195                 200                 205             


Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu 
    210                 215                 220                 


Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg 
225                 230                 235                 240 


Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser 
                245                 250                 255     


Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu 
            260                 265                 270         


Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu 
        275                 280                 285             


Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val 
    290                 295                 300                 


Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro 
305                 310                 315                 320 


Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr 
                325                 330                 335     


Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val 
            340                 345                 350         


Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu 
        355                 360                 365             


Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg 
    370                 375                 380                 


Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu 
385                 390                 395                 400 


Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile 
                405                 410                 415     


Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe 
            420                 425                 430         


Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly 
        435                 440                 445             


Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile 
    450                 455                 460                 


Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val 
465                 470                 475                 480 


Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys 
                485                 490                 495     


Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu 
            500                 505                 510         


Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu 
        515                 520                 525             


Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu 
    530                 535                 540                 


Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe 
545                 550                 555                 560 


Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp 
                565                 570                 575     


Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val 
            580                 585                 590         


Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile 
        595                 600                 605             


Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly 
    610                 615                 620                 


Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu 
625                 630                 635                 640 


Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro 
                645                 650                 655     


Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr 
            660                 665                 670         


Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val 
        675                 680                 685             


Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala 
    690                 695                 700                 


Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr 
705                 710                 715                 720 


Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp 
                725                 730                 735     


Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly 
            740                 745                 750         


Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro 
        755                 760                 765             


Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn 
    770                 775                 780                 


His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val 
785                 790                 795                 800 


Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro 
                805                 810                 815     


Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu 
            820                 825                 830         


Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr 
        835                 840                 845             


Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly 
    850                 855                 860                 


Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp 
865                 870                 875                 880 


Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys 
                885                 890                 895     


Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp 
            900                 905                 910         


Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr 
        915                 920                 925             


Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile 
    930                 935                 940                 


Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn 
945                 950                 955                 960 


Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg 
                965                 970                 975     


Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu 
            980                 985                 990         


Glu Tyr Glu Leu Lys Ser Thr Lys  Lys Gly Cys Lys Arg  Tyr Trp Thr 
        995                 1000                 1005             


Lys Thr  Ile Glu Lys Lys Leu  Ala Asn Leu Ile Asn  Ala Glu Glu 
    1010                 1015                 1020             


Arg Arg  Asp Val Ser Leu Lys  Asp Cys Met Arg Arg  Leu Phe Tyr 
    1025                 1030                 1035             


Asn Phe  Asp Lys Asn Tyr Lys  Asp Trp Gln Ser Ala  Val Glu Cys 
    1040                 1045                 1050             


Ile Ala  Val Leu Asp Val Leu  Leu Cys Leu Ala Asn  Tyr Ser Arg 
    1055                 1060                 1065             


Gly Gly  Asp Gly Pro Met Cys  Arg Pro Val Ile Leu  Leu Pro Glu 
    1070                 1075                 1080             


Asp Thr  Pro Pro Phe Leu Glu  Leu Lys Gly Ser Arg  His Pro Cys 
    1085                 1090                 1095             


Ile Thr  Lys Thr Phe Phe Gly  Asp Asp Phe Ile Pro  Asn Asp Ile 
    1100                 1105                 1110             


Leu Ile  Gly Cys Glu Glu Glu  Glu Gln Glu Asn Gly  Lys Ala Tyr 
    1115                 1120                 1125             


Cys Val  Leu Val Thr Gly Pro  Asn Met Gly Gly Lys  Ser Thr Leu 
    1130                 1135                 1140             


Met Arg  Gln Ala Gly Leu Leu  Ala Val Met Ala Gln  Met Gly Cys 
    1145                 1150                 1155             


Tyr Val  Pro Ala Glu Val Cys  Arg Leu Thr Pro Ile  Asp Arg Val 
    1160                 1165                 1170             


Phe Thr  Arg Leu Gly Ala Ser  Asp Arg Ile Met Ser  Gly Glu Ser 
    1175                 1180                 1185             


Thr Phe  Phe Val Glu Leu Ser  Glu Thr Ala Ser Ile  Leu Met His 
    1190                 1195                 1200             


Ala Thr  Ala His Ser Leu Val  Leu Val Asp Glu Leu  Gly Arg Gly 
    1205                 1210                 1215             


Thr Ala  Thr Phe Asp Gly Thr  Ala Ile Ala Asn Ala  Val Val Lys 
    1220                 1225                 1230             


Glu Leu  Ala Glu Thr Ile Lys  Cys Arg Thr Leu Phe  Ser Thr His 
    1235                 1240                 1245             


Tyr His  Ser Leu Val Glu Asp  Tyr Ser Gln Asn Val  Ala Val Arg 
    1250                 1255                 1260             


Leu Gly  His Met Ala Cys Met  Val Glu Asn Glu Cys  Glu Asp Pro 
    1265                 1270                 1275             


Ser Gln  Glu Thr Ile Thr Phe  Leu Tyr Lys Phe Ile  Lys Gly Ala 
    1280                 1285                 1290             


Cys Pro  Lys Ser Tyr Gly Phe  Asn Ala Ala Arg Leu  Ala Asn Leu 
    1295                 1300                 1305             


Pro Glu  Glu Val Ile Gln Lys  Gly His Arg Lys Ala  Arg Glu Phe 
    1310                 1315                 1320             


Glu Lys  Met Asn Gln Ser Leu  Arg Leu Phe Arg Glu  Val Cys Leu 
    1325                 1330                 1335             


Ala Ser  Glu Arg Ser Thr Val  Asp Ala Glu Ala Val  His Lys Leu 
    1340                 1345                 1350             


Leu Thr  Leu Ile Lys Glu Leu  
    1355                 1360 


<210>  3
<211>  819
<212>  PRT
<213>  Thermus thermophilus

<400>  3

Met Gly Gly Tyr Gly Gly Val Lys Met Glu Gly Met Leu Lys Gly Glu 
1               5                   10                  15      


Gly Pro Gly Pro Leu Pro Pro Leu Leu Gln Gln Tyr Val Glu Leu Arg 
            20                  25                  30          


Asp Arg Tyr Pro Asp Tyr Leu Leu Leu Phe Gln Val Gly Asp Phe Tyr 
        35                  40                  45              


Glu Cys Phe Gly Glu Asp Ala Glu Arg Leu Ala Arg Ala Leu Gly Leu 
    50                  55                  60                  


Val Leu Thr His Lys Thr Ser Lys Asp Phe Thr Thr Pro Met Ala Gly 
65                  70                  75                  80  


Ile Pro Ile Arg Ala Phe Asp Ala Tyr Ala Glu Arg Leu Leu Lys Met 
                85                  90                  95      


Gly Phe Arg Leu Ala Val Ala Asp Gln Val Glu Pro Ala Glu Glu Ala 
            100                 105                 110         


Glu Gly Leu Val Arg Arg Glu Val Thr Gln Leu Leu Thr Pro Gly Thr 
        115                 120                 125             


Leu Thr Gln Glu Ala Leu Leu Pro Arg Glu Ala Asn Tyr Leu Ala Ala 
    130                 135                 140                 


Ile Ala Thr Gly Asp Gly Trp Gly Leu Ala Phe Leu Asp Val Ser Thr 
145                 150                 155                 160 


Gly Glu Phe Lys Gly Thr Leu Leu Lys Ser Lys Ser Ala Leu Tyr Asp 
                165                 170                 175     


Glu Leu Phe Arg His Arg Pro Ala Glu Val Leu Leu Ala Pro Glu Leu 
            180                 185                 190         


Arg Glu Asn Glu Ala Phe Val Ala Glu Phe Arg Lys Arg Phe Pro Val 
        195                 200                 205             


Met Leu Ser Glu Ala Pro Phe Glu Pro Gln Gly Glu Gly Pro Leu Ala 
    210                 215                 220                 


Leu Arg Arg Ala Gln Gly Ala Leu Leu Ala Tyr Ala Arg Ala Thr Gln 
225                 230                 235                 240 


Gly Gly Ala Leu Ser Val Arg Pro Phe Arg Leu Tyr Asp Pro Gly Ala 
                245                 250                 255     


Phe Val Arg Leu Pro Glu Ala Ser Leu Lys Ala Leu Glu Val Phe Glu 
            260                 265                 270         


Pro Leu Arg Gly Gln Asp Thr Leu Phe Gly Val Leu Asp Glu Thr Arg 
        275                 280                 285             


Thr Ala Pro Gly Arg Arg Leu Leu Gln Ala Trp Leu Arg His Pro Leu 
    290                 295                 300                 


Leu Glu Arg Gly Pro Leu Glu Ala Arg Leu Asp Arg Val Glu Arg Phe 
305                 310                 315                 320 


Val Arg Glu Gly Ala Leu Arg Glu Gly Val Arg Arg Leu Leu Phe Arg 
                325                 330                 335     


Leu Ala Asp Leu Glu Arg Leu Ala Thr Arg Leu Glu Leu Ser Arg Ala 
            340                 345                 350         


Ser Pro Arg Asp Leu Ala Ala Leu Arg Arg Ser Leu Glu Ile Leu Pro 
        355                 360                 365             


Glu Leu Lys Gly Leu Leu Gly Glu Glu Val Gly Leu Pro Asp Leu Ser 
    370                 375                 380                 


Gly Leu Leu Glu Glu Leu Arg Ala Ala Leu Val Glu Asp Pro Pro Leu 
385                 390                 395                 400 


Lys Val Ser Glu Gly Gly Leu Ile Arg Glu Gly Tyr Asp Pro Asp Leu 
                405                 410                 415     


Asp Ala Leu Arg Arg Ala His Ala Glu Gly Val Ala Tyr Phe Leu Asp 
            420                 425                 430         


Leu Glu Ala Arg Glu Lys Glu Arg Thr Gly Ile Pro Thr Leu Lys Val 
        435                 440                 445             


Gly Tyr Asn Ala Val Phe Gly Tyr Tyr Leu Glu Val Thr Arg Pro Tyr 
    450                 455                 460                 


Tyr Glu Lys Val Pro Gln Glu Tyr Arg Pro Val Gln Thr Leu Lys Asp 
465                 470                 475                 480 


Arg Gln Arg Tyr Thr Leu Pro Glu Met Lys Glu Arg Glu Arg Glu Leu 
                485                 490                 495     


Tyr Arg Leu Glu Ala Leu Ile Lys Arg Arg Glu Glu Glu Val Phe Leu 
            500                 505                 510         


Ala Leu Arg Glu Arg Ala Arg Lys Glu Ala Glu Ala Leu Arg Glu Ala 
        515                 520                 525             


Ala Arg Ile Leu Ala Glu Leu Asp Val Tyr Ala Ala Leu Ala Glu Val 
    530                 535                 540                 


Ala Val Arg His Gly Tyr Thr Arg Pro Arg Phe Gly Glu Arg Leu Arg 
545                 550                 555                 560 


Ile Arg Ala Gly Arg His Pro Val Val Glu Arg Arg Thr Ala Phe Val 
                565                 570                 575     


Pro Asn Asp Leu Glu Met Ala His Glu Leu Val Leu Val Thr Gly Pro 
            580                 585                 590         


Asn Met Ala Gly Lys Ser Thr Phe Leu Arg Gln Thr Ala Leu Ile Ala 
        595                 600                 605             


Leu Leu Ala Gln Ile Gly Ser Phe Val Pro Ala Glu Glu Ala Glu Leu 
    610                 615                 620                 


Pro Leu Phe Asp Gly Ile Tyr Thr Arg Ile Gly Ala Ser Asp Asp Leu 
625                 630                 635                 640 


Ala Gly Gly Lys Ser Thr Phe Met Val Glu Met Glu Glu Val Ala Leu 
                645                 650                 655     


Val Leu Lys Glu Ala Thr Glu Arg Ser Leu Val Leu Leu Asp Glu Val 
            660                 665                 670         


Gly Arg Gly Thr Ser Ser Leu Asp Gly Val Ala Ile Ala Thr Ala Leu 
        675                 680                 685             


Ala Glu Ala Leu His Glu Arg Arg Cys Tyr Thr Leu Phe Ala Thr His 
    690                 695                 700                 


Tyr Phe Glu Leu Thr Ala Leu Ala Leu Pro Arg Leu Lys Asn Leu His 
705                 710                 715                 720 


Val Ala Ala Lys Glu Glu Glu Gly Gly Leu Val Phe Tyr His Gln Val 
                725                 730                 735     


Leu Pro Gly Pro Ala Ser Lys Ser Tyr Gly Val Glu Val Ala Glu Met 
            740                 745                 750         


Ala Gly Leu Pro Lys Glu Val Val Glu Arg Ala Arg Ala Leu Leu Ser 
        755                 760                 765             


Ala Met Ala Ala Arg Arg Glu Gly Ala Leu Glu Glu Val Leu Glu Arg 
    770                 775                 780                 


Leu Leu Ala Leu Asp Pro Asp Arg Leu Thr Pro Leu Glu Ala Leu Arg 
785                 790                 795                 800 


Phe Leu His Glu Leu Lys Ala Leu Ala Leu Gly Leu Pro Leu Gly Ser 
                805                 810                 815     


Met Lys Gly 
            


