SEQUENCE LISTING

<110>   ProQR Therapeutics II B.V.

<120>   Antisense oligonucleotides to treat dystrophic epidermolysis
        bullosa

<130>   P066271WO

<140>   n/a
<141>   2016-05-20

<150>   GB 1508733.1
<151>   2015-05-20

<150>   GB 1516505.3 
<151>   2015-09-17

<160>   33

<170>   SeqWin2010, version 1.0

<210>   1
<211>   121
<212>   DNA
<213>   Human COL7A1 gene

<400>   1
aacaggccca agtgaggccc agattgaggc tcatcagtgc cctctctatg tagggtctgc  60
agggtccaag aggcccccct ggcccagtgg tgagtaccca agaaccttca cctgtcttgc  120
c                                                                  121

<210>   2
<211>   24
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   2
ggccucuugg acccugcaga cccu                                         24

<210>   3
<211>   24
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   3
ggccucuugg acccuacaga cccu                                         24

<210>   4
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   4
ccugcagacc cuacauagag                                              20

<210>   5
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   5
cuuggacccu gcagacccua                                              20

<210>   6
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   6
gggccucuug gacccugcag                                              20

<210>   7
<211>   24
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   7
uuggguacuc accacugggc cagg                                         24

<210>   8
<211>   21
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   8
gguacucacc acugggccag g                                            21

<210>   9
<211>   24
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   9
ggcaagacag gugaagguuc uugg                                         24

<210>   10
<211>   25
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   10
cagggcacag gaugggggca agaca                                        25

<210>   11
<211>   25
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   11
gucacugggg cagggcacag gaugg                                        25

<210>   12
<211>   25
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   12
cuugggccug uucccaaccu cuggg                                        25

<210>   13
<211>   22
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   13
aucugggccu cacuugggcc ug                                           22

<210>   14
<211>   25
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   14
agggcacuga ugagccucaa ucugg                                        25

<210>   15
<211>   25
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   15
cauagagagg gcacugauga gccuc                                        25

<210>   16
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   16
caaggtccca aaggagacag                                              20

<210>   17
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   17
agtcccacag ctccagtagg                                              20

<210>   18
<211>   36
<212>   DNA
<213>   Human COL7A1 gene

<400>   18
ggtctgcagg gtccaagagg cccccctggc ccagtg                            36

<210>   19
<211>   53
<212>   DNA
<213>   Human COL7A1 gene

<400>   19
aacaggccca agtgaggccc agattgaggc tcatcagtgc cctctctatg tag         53

<210>   20
<211>   32
<212>   DNA
<213>   Human COL7A1 gene

<400>   20
gtgagtaccc aagaaccttc acctgtcttg cc                                32

<210>   21
<211>   24
<212>   DNA
<213>   Human COL7A1 gene

<400>   21
cctggcccag tggtgagtac ccaa                                         24

<210>   22
<211>   8
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   22
ucaccacu                                                           8

<210>   23
<211>   8
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   23
accacugg                                                           8

<210>   24
<211>   8
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   24
acucacca                                                           8

<210>   25
<211>   21
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   25
guacucacca cugggccagg g                                            21

<210>   26
<211>   21
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   26
uacucaccac ugggccaggg g                                            21

<210>   27
<211>   21
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   27
ggguacucac cacugggcca g                                            21

<210>   28
<211>   21
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   28
uggguacuca ccacugggcc a                                            21

<210>   29
<211>   21
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   29
uuggguacuc accacugggc c                                            21

<210>   30
<211>   36
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   30
cacugggcca ggggggccuc uuggacccug cagacc                            36

<210>   31
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   31
guacucacca cugggccagg                                              20

<210>   32
<211>   20
<212>   RNA
<213>   Artificial Sequence

<220>
<223>   Antisense oligonucleotide

<400>   32
gguacucacc acugggccag                                              20

<210>   33
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   33
gaagggggag cctggaga                                                18

