               SEQUENCE LISTING

<110> Alligator Bioscience AB

<120> NOVEL POLYPEPTIDES

<130> ALLBA/P60680PC

<150> GB1605450.4
<151> 2016-03-31

<150> GB1514994.1
<151> 2015-08-24

<150> GB1508729.9
<151> 2015-05-21

<160> 226

<170> BiSSAP 1.3.6

<210> 1
<211> 137
<212> PRT
<213> Homo sapiens


<220> 
<223> CTLA-4

<400> 1
Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile 
1               5                   10                  15      
Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val 
            20                  25                  30          
Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys 
        35                  40                  45              
Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser 
    50                  55                  60                  
Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln 
65                  70                  75                  80  
Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu 
                85                  90                  95      
Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile 
            100                 105                 110         
Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr Asn Arg Gly Leu Cys 
        115                 120                 125             
Glu Asn Ala Pro Asn Arg Ala Arg Met 
    130                 135         

<210> 2
<211> 220
<212> PRT
<213> Homo sapiens


<220> 
<223> CD28

<400> 2
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      
Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          
Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              
Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  
Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  
Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      
Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         
Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             
Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 
Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     
Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         
Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             
Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 

<210> 3
<211> 111
<212> PRT
<213> Homo sapiens


<400> 3
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 4
<211> 247
<212> PRT
<213> Homo sapiens


<400> 4
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      
Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          
Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              
Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  
Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  
Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      
Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         
His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             
Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 
Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 
His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     
Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         
Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             
Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 
Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 
Pro Pro Pro Asp His Ile Pro 
                245         

<210> 5
<211> 111
<212> PRT
<213> Homo sapiens


<400> 5
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Ala Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 6
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 900

<400> 6
Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Ile Tyr Gln Cys Val Ile His His Lys Lys Pro Ser Gly Leu Val 
                85                  90                  95      
Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 

<210> 7
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 901

<400> 7
Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Leu Thr Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Ile Tyr Gln Cys Val Ile His His Lys Lys Pro Thr Gly Met Ile 
                85                  90                  95      
Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Thr 
            100                 105                 

<210> 8
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 904

<400> 8
Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Ile Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Arg Phe Asp Ala Val Asp Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Ser Gly Met Val 
                85                  90                  95      
Lys Ile His Gln Met Asp Ser Glu Leu Ser Val Leu Ala 
            100                 105                 

<210> 9
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number number 906

<400> 9
Leu Lys Ile Gln Ala Tyr Ile Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Phe Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Leu Val 
                85                  90                  95      
Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 

<210> 10
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 907

<400> 10
Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met Ile 
                85                  90                  95      
Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 

<210> 11
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 908

<400> 11
Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met Val 
                85                  90                  95      
Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 

<210> 12
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 910

<400> 12
Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met Val 
                85                  90                  95      
Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 

<210> 13
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 915

<400> 13
Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Ile Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Phe Tyr Gln Cys Ile Ile His His Lys Lys Pro Ser Gly Leu Ile 
                85                  90                  95      
Lys Ile His Gln Met Asp Ser Glu Leu Ser Val Leu Ala 
            100                 105                 

<210> 14
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 938

<400> 14
Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      
Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          
Gln Asp Gln Glu Asn Leu Ile Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              
Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  
Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  
Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met Val 
                85                  90                  95      
Lys Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 

<210> 15
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1038

<400> 15
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Met Val Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 16
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1039

<400> 16
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Ser Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Ser Gly 
                85                  90                  95      
Met Val Lys Ile His Gln Met Asp Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 17
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1040

<400> 17
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 18
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1041

<400> 18
Ala Pro Leu Lys Ile Gln Ala Tyr Leu Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Leu Val Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 19
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1042

<400> 19
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Ile Phe Asp Ser Val Ser Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Ser Gly 
                85                  90                  95      
Met Val Lys Ile His Gln Met Asp Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 20
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1043

<400> 20
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Met Ile Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 21
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1044

<400> 21
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Thr Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Ser Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Met Ile Lys Ile His Glu Met Ser Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 22
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1045

<400> 22
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Thr Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Leu Val Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 23
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1046

<400> 23
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Glu 
65                  70                  75                  80  
Asp Lys Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Ser Gly 
                85                  90                  95      
Met Val Lys Ile His Gln Met Asp Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 24
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1047

<400> 24
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              
Lys Glu Lys Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  
Asp Lys Gly Ile Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      
Leu Val Lys Ile His Glu Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     

<210> 25
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 900

<400> 25
ctcaaaatcc aagcgtactt caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatcaaa gcctgagcga actggtggtt ttctggcagg atcaggagaa cctggttctg     120

aacgaagtct atctgggcaa agagaaattc gacagcgtgg acagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtatctacc agtgcgtgat ccaccataag aagccgagcg gtctggtgaa gattcacgag     300

atgaactccg agttgtctgt cctggcg                                         327


<210> 26
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 901

<400> 26
ctcaaaatcc aagcgtactt caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatctga ccctgagcga actggtggtt ttctggcagg atcaggagaa cctggttctg     120

aacgaagtct atctgggcaa agagaaattc gacagcgtgc atagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtatctacc agtgcgtgat ccaccataag aagccgacgg gtatgattaa gattcacgag     300

atgaactccg agttgtctgt cctgacc                                         327


<210> 27
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 904

<400> 27
ctcaaaatcc aagcgtactt caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatcaaa gcctgagcga actgatcgtt ttctggcagg atcaggagaa cctggttctg     120

aacgaagtct atctgggcaa agagcggttc gacgccgtgg acagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtatctacc agtgcattat ccaccataag aagccgagcg gtatggtgaa gattcaccaa     300

atggactccg agttgtctgt cctggcg                                         327


<210> 28
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 906

<400> 28
ctcaaaatcc aagcgtacat caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatctga gcctgagcga actggtggtt ttctggcagg atcaggagaa cctggttctg     120

aacgaagtct atctgggcaa agagcggttc gacagcgtgg acagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtttctacc agtgcattat ccaccataag aagccgacgg gtctggtgaa gattcacgag     300

atgaactccg agttgtctgt cctggcg                                         327


<210> 29
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 907

<400> 29
ctcaaaatcc aagcgtactt caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatcaaa gcctgagcga actggtggtt ttctggcagg atcaggagaa cctggttctg     120

aacgaagtct atctgggcaa agagaaattc gacagcgtgc atagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtctgtacc agtgcattat ccaccataag aagccgacgg gtatgattaa gattcacgag     300

atgaactccg agttgtctgt cctggcg                                         327


<210> 30
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 908

<400> 30
ctcaaaatcc aagcgtactt caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatcaaa gcctgagcga actggtggtt ttctggcagg atcaggagaa cctggttctg     120

aacgaagtct atctgggcaa agagaaattc gacagcgtgc atagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtatctacc agtgcattat ccaccataag aagccgacgg gtatggtgaa gattcacgag     300

atgaactccg agttgtctgt cctggcg                                         327


<210> 31
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 910

<400> 31
ctcaaaatcc aagcgtactt caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatcaaa gcctgagcga actggtggtt ttctggcagg atcaggagaa cctggttctg     120

aacgaagtct atctgggcaa agagaaattc gacagcgtgg acagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtatctacc agtgcattat ccaccataag aagccgacgg gtatggtgaa gattcacgag     300

atgaactccg agttgtctgt cctggcg                                         327


<210> 32
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence for clone number 915

<400> 32
ctcaaaatcc aagcgtactt caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatcaaa gcctgagcga actggtggtt ttctggcagg atcaggagaa cctgatcctg     120

aacgaagtct atctgggcaa agagaaattc gacagcgtgg acagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtttctacc agtgcattat ccaccataag aagccgagcg gtctgattaa gattcaccaa     300

atggactccg agttgtctgt cctggcg                                         327


<210> 33
<211> 327
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 938

<400> 33
ctcaaaatcc aagcgtactt caacgaaact gcagacttac cgtgtcagtt tgccaattcg      60

cagaatctga gcctgagcga actggtggtt ttctggcagg atcaggagaa cctgatcctg     120

aacgaagtct atctgggcaa agagcggttc gacagcgtgc atagcaagta tatgggccgc     180

accagctttg atagcgacag ctggaccctg cgtctgcaca atctgcaaat caaagataag     240

ggtctgtacc agtgcattat ccaccataag aagccgagcg gtatggtgaa gattcacgag     300

atgaactccg agttgtctgt cctggcg                                         327


<210> 34
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1038

<400> 34
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgagcct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag aaattcgaca gcgtggacag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggta tctaccagtg cattatccac cataagaagc cgacgggtat ggtgaagatt     300

cacgagatga actccgagtt gtctgtcctg gcg                                  333


<210> 35
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1039

<400> 35
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgagcct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag aaattcgaca gcgtgagtag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggta tctaccagtg cattatccac cataagaagc cgagcggtat ggtgaagatt     300

caccaaatgg actccgagtt gtctgtcctg gcg                                  333


<210> 36
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1040

<400> 36
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgagcct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag cggttcgaca gcgtggacag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggta ggtaccagtg cattatccac cataagaagc cgacgggtat gattaatatt     300

caccaaatga actccgagtt gtctgtcctg gcg                                  333


<210> 37
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1041

<400> 37
gcccccctca aaatccaagc gtacctcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgagcct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag aaattcgaca gcgtggacag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggta tctaccagtg cattatccac cataagaagc cgacgggtct ggtgaagatt     300

cacgagatga actccgagtt gtctgtcctg gcg                                  333


<210> 38
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1042

<400> 38
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgagcct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag attttcgaca gcgtgagtag caagtatatg     180

ggccgcacca gctttgatag tgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggta tctaccagtg cattatccac cataagaagc cgagcggtat ggtgaagatt     300

caccaaatgg actccgagtt gtctgtcctg gcg                                  333


<210> 39
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1043

<400> 39
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgagcct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag aaattcgaca gcgtggatag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggta tctaccagtg cattatccac cataagaagc cgacgggtat gattaagatt     300

cacgagatga actccgagtt gtctgtcctg gcg                                  333


<210> 40
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1044

<400> 40
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgaccct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag aaattcgaca gcgtgtctag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggta tctaccagtg cattatccac cataagaagc cgacgggtat gattaagatt     300

cacgagatga gctccgagtt gtctgtcctg gcg                                  333


<210> 41
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1045

<400> 41
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgaccct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag aaattcgaca gcgtggacag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggtc tgtaccagtg cattatccac cataagaagc cgacgggtct ggtgaagatt     300

cacgagatga actccgagtt gtctgtcctg gcg                                  333


<210> 42
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1046

<400> 42
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atcaaagcct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag aaattcgaca gcgtggacag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcgaa     240

gataagggta tctaccagtg cattatccac cataagaagc cgagcggtat ggtgaagatt     300

caccaaatgg actccgagtt gtctgtcctg gcg                                  333


<210> 43
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence of clone number 1047

<400> 43
gcccccctca aaatccaagc gtacttcaac gaaactgcag acttaccgtg tcagtttgcc      60

aattcgcaga atctgagcct gagcgaactg gtggttttct ggcaggatca ggagaacctg     120

gttctgaacg aagtctatct gggcaaagag aaattcgaca gcgtggacag caagtatatg     180

ggccgcacca gctttgatag cgacagctgg accctgcgtc tgcacaatct gcaaatcaaa     240

gataagggta tctaccagtg cattatccac cataagaagc cgacgggtct ggtgaagatt     300

cacgagatga actccgagtt gtctgtcctg gcg                                  333


<210> 44
<211> 329
<212> PRT
<213> Homo sapiens


<400> 44
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      
Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          
Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              
Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  
Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  
Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      
Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         
His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             
Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 
Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 
His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     
Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         
Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             
Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 
Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 
Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     
Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         
Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             
Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 
Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 
Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 

<210> 45
<211> 223
<212> PRT
<213> Mus musculus


<400> 45
Met Ala Cys Leu Gly Leu Arg Arg Tyr Lys Ala Gln Leu Gln Leu Pro 
1               5                   10                  15      
Ser Arg Thr Trp Pro Phe Val Ala Leu Leu Thr Leu Leu Phe Ile Pro 
            20                  25                  30          
Val Phe Ser Glu Ala Ile Gln Val Thr Gln Pro Ser Val Val Leu Ala 
        35                  40                  45              
Ser Ser His Gly Val Ala Ser Phe Pro Cys Glu Tyr Ser Pro Ser His 
    50                  55                  60                  
Asn Thr Asp Glu Val Arg Val Thr Val Leu Arg Gln Thr Asn Asp Gln 
65                  70                  75                  80  
Met Thr Glu Val Cys Ala Thr Thr Phe Thr Glu Lys Asn Thr Val Gly 
                85                  90                  95      
Phe Leu Asp Tyr Pro Phe Cys Ser Gly Thr Phe Asn Glu Ser Arg Val 
            100                 105                 110         
Asn Leu Thr Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Leu 
        115                 120                 125             
Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val Gly Met Gly 
    130                 135                 140                 
Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 
Asp Phe Leu Leu Trp Ile Leu Val Ala Val Ser Leu Gly Leu Phe Phe 
                165                 170                 175     
Tyr Ser Phe Leu Val Ser Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         
Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             
Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             

<210> 46
<211> 218
<212> PRT
<213> Mus musculus


<400> 46
Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      
Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          
Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              
Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  
Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  
Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      
Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         
Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             
Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 
Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 
Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     
Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Val Thr Thr Met Asn Met 
            180                 185                 190         
Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             
Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             

<210> 47
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker sequence

<400> 47
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      

<210> 48
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker sequence

<400> 48
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro 
1               5                   10              

<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker sequence

<400> 49
Asn Phe Ser Gln Pro 
1               5   

<210> 50
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker sequence

<400> 50
Lys Arg Thr Val Ala 
1               5   

<210> 51
<211> 277
<212> PRT
<213> Homo sapiens


<400> 51
Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      
Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          
Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              
Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  
Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  
Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      
Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         
Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             
Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 
Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 
Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     
Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         
Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             
Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 
Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 
Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     
Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         
Thr Leu Ala Lys Ile 
        275         

<210> 52
<211> 8
<212> PRT
<213> Homo sapiens


<400> 52
Gly Phe Thr Phe Gly Gly Tyr Tyr 
1               5               

<210> 53
<211> 8
<212> PRT
<213> Homo sapiens


<400> 53
Gly Phe Thr Phe Tyr Gly Ser Ser 
1               5               

<210> 54
<211> 8
<212> PRT
<213> Homo sapiens


<400> 54
Gly Phe Thr Phe Ser Gly Ser Ser 
1               5               

<210> 55
<211> 8
<212> PRT
<213> Homo sapiens


<400> 55
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 56
<211> 8
<212> PRT
<213> Homo sapiens


<400> 56
Gly Phe Thr Phe Gly Tyr Tyr Tyr 
1               5               

<210> 57
<211> 8
<212> PRT
<213> Homo sapiens


<400> 57
Gly Phe Thr Phe Gly Ser Tyr Tyr 
1               5               

<210> 58
<211> 8
<212> PRT
<213> Homo sapiens


<400> 58
Gly Phe Thr Phe Ser Gly Tyr Ser 
1               5               

<210> 59
<211> 8
<212> PRT
<213> Homo sapiens


<400> 59
Gly Phe Thr Phe Gly Ser Ser Ser 
1               5               

<210> 60
<211> 8
<212> PRT
<213> Homo sapiens


<400> 60
Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               

<210> 61
<211> 8
<212> PRT
<213> Homo sapiens


<400> 61
Ile Pro Gly Ser Gly Gly Ser Thr 
1               5               

<210> 62
<211> 8
<212> PRT
<213> Homo sapiens


<400> 62
Ile Tyr Ser Ser Gly Gly Tyr Thr 
1               5               

<210> 63
<211> 8
<212> PRT
<213> Homo sapiens


<400> 63
Ile Ser Tyr Tyr Gly Gly Tyr Thr 
1               5               

<210> 64
<211> 8
<212> PRT
<213> Homo sapiens


<400> 64
Ile Ser Tyr Tyr Ser Gly Tyr Thr 
1               5               

<210> 65
<211> 8
<212> PRT
<213> Homo sapiens


<400> 65
Ile Ser Ser Tyr Gly Ser Tyr Thr 
1               5               

<210> 66
<211> 8
<212> PRT
<213> Homo sapiens


<400> 66
Ile Gly Ser Tyr Tyr Gly Tyr Thr 
1               5               

<210> 67
<211> 8
<212> PRT
<213> Homo sapiens


<400> 67
Ile Gly Tyr Ser Gly Tyr Gly Thr 
1               5               

<210> 68
<211> 9
<212> PRT
<213> Homo sapiens


<400> 68
Ile Gly Tyr Tyr Ser Tyr Ser Thr Ser 
1               5                   

<210> 69
<211> 10
<212> PRT
<213> Homo sapiens


<400> 69
Ala Arg Tyr Asp Tyr Ala Ser Met Asp Tyr 
1               5                   10  

<210> 70
<211> 10
<212> PRT
<213> Homo sapiens


<400> 70
Ala Arg Tyr Asp Tyr Tyr Trp Met Asp Tyr 
1               5                   10  

<210> 71
<211> 11
<212> PRT
<213> Homo sapiens


<400> 71
Ala Arg Gly Val Pro His Gly Tyr Phe Asp Tyr 
1               5                   10      

<210> 72
<211> 11
<212> PRT
<213> Homo sapiens


<400> 72
Ala Arg Tyr Phe Pro His Tyr Tyr Phe Asp Tyr 
1               5                   10      

<210> 73
<211> 9
<212> PRT
<213> Homo sapiens


<400> 73
Ala Arg Gly Tyr Gly Tyr Leu Asp Tyr 
1               5                   

<210> 74
<211> 11
<212> PRT
<213> Homo sapiens


<400> 74
Ala Arg Tyr Tyr Pro His His Tyr Ile Asp Tyr 
1               5                   10      

<210> 75
<211> 14
<212> PRT
<213> Homo sapiens


<400> 75
Ala Arg Ser Gly Tyr Ser Asn Trp Ala Asn Ser Phe Asp Tyr 
1               5                   10                  

<210> 76
<211> 17
<212> PRT
<213> Homo sapiens


<400> 76
Ala Arg Tyr Tyr Tyr Ser His Gly Tyr Tyr Val Tyr Gly Thr Leu Asp 
1               5                   10                  15      
Tyr 
    

<210> 77
<211> 10
<212> PRT
<213> Homo sapiens


<400> 77
Ala Arg His Asp Tyr Gly Ala Leu Asp Tyr 
1               5                   10  

<210> 78
<211> 15
<212> PRT
<213> Homo sapiens


<400> 78
Ala Arg Tyr Tyr Phe His Asp Tyr Ala Ala Tyr Ser Leu Asp Tyr 
1               5                   10                  15  

<210> 79
<211> 11
<212> PRT
<213> Homo sapiens


<400> 79
Ala Arg Gly Tyr Pro His His Tyr Phe Asp Tyr 
1               5                   10      

<210> 80
<211> 6
<212> PRT
<213> Homo sapiens


<400> 80
Gln Ser Ile Ser Ser Tyr 
1               5       

<210> 81
<211> 3
<212> PRT
<213> Homo sapiens


<400> 81
Ala Ala Ser 
1           

<210> 82
<211> 10
<212> PRT
<213> Homo sapiens


<400> 82
Gln Gln Tyr Tyr Trp Tyr Gly Leu Ser Thr 
1               5                   10  

<210> 83
<211> 10
<212> PRT
<213> Homo sapiens


<400> 83
Gln Gln Gly His Gly Ser Tyr Pro His Thr 
1               5                   10  

<210> 84
<211> 9
<212> PRT
<213> Homo sapiens


<400> 84
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   

<210> 85
<211> 8
<212> PRT
<213> Homo sapiens


<400> 85
Gln Gln Tyr Gly Ser Leu Leu Thr 
1               5               

<210> 86
<211> 9
<212> PRT
<213> Homo sapiens


<400> 86
Gln Gln Gly Asp Tyr Thr Leu Phe Thr 
1               5                   

<210> 87
<211> 10
<212> PRT
<213> Homo sapiens


<400> 87
Gln Gln Tyr Gly Pro Ser Gly Leu Phe Thr 
1               5                   10  

<210> 88
<211> 10
<212> PRT
<213> Homo sapiens


<400> 88
Gln Gln Tyr Gly Ser Asp Ser Leu Leu Thr 
1               5                   10  

<210> 89
<211> 108
<212> PRT
<213> Homo sapiens


<400> 89
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Trp Tyr Gly Leu 
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 90
<211> 324
<212> DNA
<213> Homo sapiens


<400> 90
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tactactggt acggtctgtc cacttttggc     300

caggggacca agctggagat caaa                                            324


<210> 91
<211> 117
<212> PRT
<213> Homo sapiens


<400> 91
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Asp Tyr Ala Ser Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 92
<211> 351
<212> DNA
<213> Homo sapiens


<400> 92
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt ggttactaca tgtcttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctacgac     300

tacgcttcta tggactattg gggccaggga accctggtca ccgtctcctc a              351


<210> 93
<211> 108
<212> PRT
<213> Homo sapiens


<400> 93
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Gly Ser Tyr Pro 
                85                  90                  95      
His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 94
<211> 324
<212> DNA
<213> Homo sapiens


<400> 94
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtcatggtt cttacccgca cacttttggc     300

caggggacca agctggagat caaa                                            324


<210> 95
<211> 117
<212> PRT
<213> Homo sapiens


<400> 95
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Pro Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Asp Tyr Tyr Trp Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 96
<211> 351
<212> DNA
<213> Homo sapiens


<400> 96
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt ggttactaca tgtcttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatac attcctggtt ctggtggttc tacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctacgac     300

tactactgga tggactattg gggccaggga accctggtca ccgtctcctc a              351


<210> 97
<211> 107
<212> PRT
<213> Homo sapiens


<400> 97
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 98
<211> 321
<212> DNA
<213> Homo sapiens


<400> 98
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag agttacagta ccccttatac ttttggccag     300

gggaccaagc tggagatcaa a                                               321


<210> 99
<211> 118
<212> PRT
<213> Homo sapiens


<400> 99
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Gly Ser 
            20                  25                  30          
Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Tyr Ser Ser Gly Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Val Pro His Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 100
<211> 354
<212> DNA
<213> Homo sapiens


<400> 100
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt caccttttac ggttcttcta tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt atttactctt ctggtggtta cacatcttat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcggtgtt     300

cctcatggtt actttgacta ttggggccag ggaaccctgg tcaccgtctc ctca           354


<210> 101
<211> 118
<212> PRT
<213> Homo sapiens


<400> 101
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Tyr Tyr Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Phe Pro His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 102
<211> 354
<212> DNA
<213> Homo sapiens


<400> 102
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagt ggttcttcta tgtcttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatct atttcttact acggtggtta cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctacttc     300

ccgcattact actttgacta ttggggccag ggaaccctgg tcaccgtctc ctca           354


<210> 103
<211> 106
<212> PRT
<213> Homo sapiens


<400> 103
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Leu Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 104
<211> 318
<212> DNA
<213> Homo sapiens


<400> 104
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tacggttctc tgctcacttt tggccagggg     300

accaagctgg agatcaaa                                                   318


<210> 105
<211> 116
<212> PRT
<213> Homo sapiens


<400> 105
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Ser Tyr Tyr Ser Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 106
<211> 348
<212> DNA
<213> Homo sapiens


<400> 106
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatac atttcttact actctggtta cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcggttac     300

ggttacttgg actattgggg ccagggaacc ctggtcaccg tctcctca                  348


<210> 107
<211> 118
<212> PRT
<213> Homo sapiens


<400> 107
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Tyr Tyr Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Pro His His Tyr Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 108
<211> 354
<212> DNA
<213> Homo sapiens


<400> 108
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt atttcttact acggtggtta cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctactac     300

ccgcatcatt acattgacta ttggggccag ggaaccctgg tcaccgtctc ctca           354


<210> 109
<211> 107
<212> PRT
<213> Homo sapiens


<400> 109
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Tyr Thr Leu Phe 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 110
<211> 321
<212> DNA
<213> Homo sapiens


<400> 110
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtgattaca ctctgttcac ttttggccag     300

gggaccaagc tggagatcaa a                                               321


<210> 111
<211> 121
<212> PRT
<213> Homo sapiens


<400> 111
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Tyr Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Ser Tyr Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Tyr Ser Asn Trp Ala Asn Ser Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 112
<211> 363
<212> DNA
<213> Homo sapiens


<400> 112
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt tactactaca tgtcttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt atttcttctt acggtagtta cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctctggt     300

tactctaact gggctaactc ttttgactat tggggccagg gaaccctggt caccgtctcc     360

tca                                                                   363


<210> 113
<211> 124
<212> PRT
<213> Homo sapiens


<400> 113
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Tyr Ser His Gly Tyr Tyr Val Tyr Gly Thr Leu Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 

<210> 114
<211> 372
<212> DNA
<213> Homo sapiens


<400> 114
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctactac     300

tactctcatg gttactacgt ttacggtact ttggactatt ggggccaggg aaccctggtc     360

accgtctcct ca                                                         372


<210> 115
<211> 108
<212> PRT
<213> Homo sapiens


<400> 115
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Pro Ser Gly Leu 
                85                  90                  95      
Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 116
<211> 324
<212> DNA
<213> Homo sapiens


<400> 116
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tacggtccgt ctggtctgtt cacttttggc     300

caggggacca agctggagat caaa                                            324


<210> 117
<211> 117
<212> PRT
<213> Homo sapiens


<400> 117
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          
Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Gly Ser Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Asp Tyr Gly Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 118
<211> 351
<212> DNA
<213> Homo sapiens


<400> 118
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt tcttactaca tgggttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatct attggttctt actacggtta cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgccatgac     300

tacggtgctt tggactattg gggccaggga accctggtca ccgtctcctc a              351


<210> 119
<211> 108
<212> PRT
<213> Homo sapiens


<400> 119
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Asp Ser Leu 
                85                  90                  95      
Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 120
<211> 324
<212> DNA
<213> Homo sapiens


<400> 120
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tacggttctg attctctgct cacttttggc     300

caggggacca agctggagat caaa                                            324


<210> 121
<211> 122
<212> PRT
<213> Homo sapiens


<400> 121
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          
Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Gly Tyr Ser Gly Tyr Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Phe His Asp Tyr Ala Ala Tyr Ser Leu Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210> 122
<211> 366
<212> DNA
<213> Homo sapiens


<400> 122
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt caccttttct ggttactcta tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt attggttact ctggttacgg tacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctactac     300

ttccatgact acgctgctta ctctttggac tattggggcc agggaaccct ggtcaccgtc     360

tcctca                                                                366


<210> 123
<211> 118
<212> PRT
<213> Homo sapiens


<400> 123
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Ser 
            20                  25                  30          
Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Gly Tyr Tyr Ser Tyr Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Pro His His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 124
<211> 354
<212> DNA
<213> Homo sapiens


<400> 124
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt tcttcttcta tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt attggttact actcttactc tacatcttat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcggttac     300

ccgcatcatt actttgacta ttggggccag ggaaccctgg tcaccgtctc ctca           354


<210> 125
<211> 337
<212> PRT
<213> Homo sapiens


<400> 125
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Trp Tyr Gly Leu 
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 
Gly Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp 
225                 230                 235                 240 
Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu 
                245                 250                 255     
Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr 
            260                 265                 270         
Leu Gly Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg 
        275                 280                 285             
Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln 
    290                 295                 300                 
Ile Lys Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro 
305                 310                 315                 320 
Thr Gly Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                325                 330                 335     
Ala 
    

<210> 126
<211> 1376
<212> DNA
<213> Homo sapiens


<400> 126
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tactactggt acggtctgtc cacttttggc     300

caggggacca agctggagat caaacgtgag tcgtacgcta gcaagcttga tatcgaattc     360

taaactctga gggggtcgga tgacgtggcc attctttgcc taaagcattg agtttactgc     420

aaggtcagaa aagcatgcaa agccctcaga atggctgcaa agagctccaa caaaacaatt     480

tagaacttta ttaaggaata gggggaagct aggaagaaac tcaaaacatc aagattttaa     540

atacgcttct tggtctcctt gctataatta tctgggataa gcatgctgtt ttctgtctgt     600

ccctaacatg ccctgtgatt atccgcaaac aacacaccca agggcagaac tttgttactt     660

aaacaccatc ctgtttgctt ctttcctcag gaactgtggc tgcaccatct gtcttcatct     720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata     780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta     840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca     900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     960

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt agcggaggag    1020

gaggaagcgg aggaggagga agcgcccccc tcaaaatcca agcgtacttc aacgaaactg    1080

cagacttacc gtgtcagttt gccaattcgc agaatctgag cctgagcgaa ctggtggttt    1140

tctggcagga tcaggagaac ctggttctga acgaagtcta tctgggcaaa gagcggttcg    1200

acagcgtgga cagcaagtat atgggccgca ccagctttga tagcgacagc tggaccctgc    1260

gtctgcacaa tctgcaaatc aaagataagg gtaggtacca gtgcattatc caccataaga    1320

agccgacggg tatgattaat attcaccaaa tgaactccga gttgtctgtc ctggcg        1376


<210> 127
<211> 337
<212> PRT
<213> Homo sapiens


<400> 127
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Gly Ser Tyr Pro 
                85                  90                  95      
His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 
Gly Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp 
225                 230                 235                 240 
Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu 
                245                 250                 255     
Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr 
            260                 265                 270         
Leu Gly Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg 
        275                 280                 285             
Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln 
    290                 295                 300                 
Ile Lys Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro 
305                 310                 315                 320 
Thr Gly Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                325                 330                 335     
Ala 
    

<210> 128
<211> 1376
<212> DNA
<213> Homo sapiens


<400> 128
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtcatggtt cttacccgca cacttttggc     300

caggggacca agctggagat caaacgtgag tcgtacgcta gcaagcttga tatcgaattc     360

taaactctga gggggtcgga tgacgtggcc attctttgcc taaagcattg agtttactgc     420

aaggtcagaa aagcatgcaa agccctcaga atggctgcaa agagctccaa caaaacaatt     480

tagaacttta ttaaggaata gggggaagct aggaagaaac tcaaaacatc aagattttaa     540

atacgcttct tggtctcctt gctataatta tctgggataa gcatgctgtt ttctgtctgt     600

ccctaacatg ccctgtgatt atccgcaaac aacacaccca agggcagaac tttgttactt     660

aaacaccatc ctgtttgctt ctttcctcag gaactgtggc tgcaccatct gtcttcatct     720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata     780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta     840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca     900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     960

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt agcggaggag    1020

gaggaagcgg aggaggagga agcgcccccc tcaaaatcca agcgtacttc aacgaaactg    1080

cagacttacc gtgtcagttt gccaattcgc agaatctgag cctgagcgaa ctggtggttt    1140

tctggcagga tcaggagaac ctggttctga acgaagtcta tctgggcaaa gagcggttcg    1200

acagcgtgga cagcaagtat atgggccgca ccagctttga tagcgacagc tggaccctgc    1260

gtctgcacaa tctgcaaatc aaagataagg gtaggtacca gtgcattatc caccataaga    1320

agccgacggg tatgattaat attcaccaaa tgaactccga gttgtctgtc ctggcg        1376


<210> 129
<211> 336
<212> PRT
<213> Homo sapiens


<400> 129
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 
Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
225                 230                 235                 240 
Pro Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val 
                245                 250                 255     
Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
            260                 265                 270         
Gly Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr 
        275                 280                 285             
Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
    290                 295                 300                 
Lys Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
305                 310                 315                 320 
Gly Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
                325                 330                 335     



<210> 130
<211> 1373
<212> DNA
<213> Homo sapiens


<400> 130
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag agttacagta ccccttatac ttttggccag     300

gggaccaagc tggagatcaa acgtgagtcg tacgctagca agcttgatat cgaattctaa     360

actctgaggg ggtcggatga cgtggccatt ctttgcctaa agcattgagt ttactgcaag     420

gtcagaaaag catgcaaagc cctcagaatg gctgcaaaga gctccaacaa aacaatttag     480

aactttatta aggaataggg ggaagctagg aagaaactca aaacatcaag attttaaata     540

cgcttcttgg tctccttgct ataattatct gggataagca tgctgttttc tgtctgtccc     600

taacatgccc tgtgattatc cgcaaacaac acacccaagg gcagaacttt gttacttaaa     660

caccatcctg tttgcttctt tcctcaggaa ctgtggctgc accatctgtc ttcatcttcc     720

cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact     780

tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact     840

cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc     900

tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc     960

agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtagc ggaggaggag    1020

gaagcggagg aggaggaagc gcccccctca aaatccaagc gtacttcaac gaaactgcag    1080

acttaccgtg tcagtttgcc aattcgcaga atctgagcct gagcgaactg gtggttttct    1140

ggcaggatca ggagaacctg gttctgaacg aagtctatct gggcaaagag cggttcgaca    1200

gcgtggacag caagtatatg ggccgcacca gctttgatag cgacagctgg accctgcgtc    1260

tgcacaatct gcaaatcaaa gataagggta ggtaccagtg cattatccac cataagaagc    1320

cgacgggtat gattaatatt caccaaatga actccgagtt gtctgtcctg gcg           1373


<210> 131
<211> 336
<212> PRT
<213> Homo sapiens


<400> 131
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Tyr Thr Leu Phe 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 
Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
225                 230                 235                 240 
Pro Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val 
                245                 250                 255     
Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
            260                 265                 270         
Gly Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr 
        275                 280                 285             
Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
    290                 295                 300                 
Lys Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
305                 310                 315                 320 
Gly Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
                325                 330                 335     



<210> 132
<211> 1373
<212> DNA
<213> Homo sapiens


<400> 132
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtgattaca ctctgttcac ttttggccag     300

gggaccaagc tggagatcaa acgtgagtcg tacgctagca agcttgatat cgaattctaa     360

actctgaggg ggtcggatga cgtggccatt ctttgcctaa agcattgagt ttactgcaag     420

gtcagaaaag catgcaaagc cctcagaatg gctgcaaaga gctccaacaa aacaatttag     480

aactttatta aggaataggg ggaagctagg aagaaactca aaacatcaag attttaaata     540

cgcttcttgg tctccttgct ataattatct gggataagca tgctgttttc tgtctgtccc     600

taacatgccc tgtgattatc cgcaaacaac acacccaagg gcagaacttt gttacttaaa     660

caccatcctg tttgcttctt tcctcaggaa ctgtggctgc accatctgtc ttcatcttcc     720

cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact     780

tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact     840

cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc     900

tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc     960

agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtagc ggaggaggag    1020

gaagcggagg aggaggaagc gcccccctca aaatccaagc gtacttcaac gaaactgcag    1080

acttaccgtg tcagtttgcc aattcgcaga atctgagcct gagcgaactg gtggttttct    1140

ggcaggatca ggagaacctg gttctgaacg aagtctatct gggcaaagag cggttcgaca    1200

gcgtggacag caagtatatg ggccgcacca gctttgatag cgacagctgg accctgcgtc    1260

tgcacaatct gcaaatcaaa gataagggta ggtaccagtg cattatccac cataagaagc    1320

cgacgggtat gattaatatt caccaaatga actccgagtt gtctgtcctg gcg           1373


<210> 133
<211> 337
<212> PRT
<213> Homo sapiens


<400> 133
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Asp Ser Leu 
                85                  90                  95      
Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 
Gly Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp 
225                 230                 235                 240 
Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu 
                245                 250                 255     
Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr 
            260                 265                 270         
Leu Gly Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg 
        275                 280                 285             
Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln 
    290                 295                 300                 
Ile Lys Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro 
305                 310                 315                 320 
Thr Gly Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                325                 330                 335     
Ala 
    

<210> 134
<211> 1376
<212> DNA
<213> Homo sapiens


<400> 134
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tacggttctg attctctgct cacttttggc     300

caggggacca agctggagat caaacgtgag tcgtacgcta gcaagcttga tatcgaattc     360

taaactctga gggggtcgga tgacgtggcc attctttgcc taaagcattg agtttactgc     420

aaggtcagaa aagcatgcaa agccctcaga atggctgcaa agagctccaa caaaacaatt     480

tagaacttta ttaaggaata gggggaagct aggaagaaac tcaaaacatc aagattttaa     540

atacgcttct tggtctcctt gctataatta tctgggataa gcatgctgtt ttctgtctgt     600

ccctaacatg ccctgtgatt atccgcaaac aacacaccca agggcagaac tttgttactt     660

aaacaccatc ctgtttgctt ctttcctcag gaactgtggc tgcaccatct gtcttcatct     720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata     780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta     840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca     900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     960

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt agcggaggag    1020

gaggaagcgg aggaggagga agcgcccccc tcaaaatcca agcgtacttc aacgaaactg    1080

cagacttacc gtgtcagttt gccaattcgc agaatctgag cctgagcgaa ctggtggttt    1140

tctggcagga tcaggagaac ctggttctga acgaagtcta tctgggcaaa gagcggttcg    1200

acagcgtgga cagcaagtat atgggccgca ccagctttga tagcgacagc tggaccctgc    1260

gtctgcacaa tctgcaaatc aaagataagg gtaggtacca gtgcattatc caccataaga    1320

agccgacggg tatgattaat attcaccaaa tgaactccga gttgtctgtc ctggcg        1376


<210> 135
<211> 330
<212> PRT
<213> Homo sapiens


<400> 135
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 136
<211> 107
<212> PRT
<213> Homo sapiens


<400> 136
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210> 137
<211> 327
<212> PRT
<213> Homo sapiens


<400> 137
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210> 138
<211> 327
<212> PRT
<213> Homo sapiens


<400> 138
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210> 139
<211> 327
<212> PRT
<213> Homo sapiens


<400> 139
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210> 140
<211> 981
<212> DNA
<213> Homo sapiens


<400> 140
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg     120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc     240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc     300

aaatatggtc ccccatgccc accttgccca gcacctgagt tcctgggggg accatcagtc     360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg     420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat     480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac     540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accgctacac acagaagagc     960

ctctccctgt ctctgggtaa a                                               981


<210> 141
<211> 2028
<212> DNA
<213> Homo sapiens


<400> 141
agctttctgg ggcaggccgg gcctgacttt ggctgggggc agggaggggg ctaaggtgac      60

gcaggtggcg ccagccaggt gcacacccaa tgcccatgag cccagacact ggaccctgca     120

tggaccatcg cggatagaca agaaccgagg ggcctctgcg ccctgggccc agctctgtcc     180

cacaccgcgg tcacatggca ccacctctct tgcagcttcc accaagggcc catccgtctt     240

ccccctggcg ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt     300

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     360

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     420

gaccgtgccc tccagcagct tgggcacgaa gacctacacc tgcaacgtag atcacaagcc     480

cagcaacacc aaggtggaca agagagttgg tgagaggcca gcacagggag ggagggtgtc     540

tgctggaagc caggctcagc cctcctgcct ggacgcaccc cggctgtgca gccccagccc     600

agggcagcaa ggcatgcccc atctgtctcc tcacccggag gcctctgacc accccactca     660

tgctcaggga gagggtcttc tggatttttc caccaggctc ccggcaccac aggctggatg     720

cccctacccc aggccctgcg catacagggc aggtgctgcg ctcagacctg ccaagagcca     780

tatccgggag gaccctgccc ctgacctaag cccaccccaa aggccaaact ctccactccc     840

tcagctcaga caccttctct cctcccagat ctgagtaact cccaatcttc tctctgcaga     900

gtccaaatat ggtcccccat gcccaccttg cccaggtaag ccaacccagg cctcgccctc     960

cagctcaagg cgggacaggt gccctagagt agcctgcatc cagggacagg ccccagccgg    1020

gtgctgacgc atccacctcc atctcttcct cagcacctga gttcctgggg ggaccatcag    1080

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca    1140

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg    1200

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt    1260

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca    1320

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca    1380

aaggtgggac ccacggggtg cgagggccac acggacagag gccagctcgg cccaccctct    1440

gccctgggag tgaccgctgt gccaacctct gtccctacag ggcagccccg agagccacag    1500

gtgtacaccc tgcccccatc ccaggaggag atgaccaaga accaggtcag cctgacctgc    1560

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg    1620

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac    1680

agcaggctaa ccgtggacaa gagcaggtgg caggagggga atgtcttctc atgctccgtg    1740

atgcatgagg ctctgcacaa ccgctacaca cagaagagcc tctccctgtc tctgggtaaa    1800

tgagtgccag ggccggcaag cccccgctcc ccgggctctc ggggtcgcgc gaggatgctt    1860

ggcacgtacc ccgtctacat acttcccagg cacccagcat ggaaataaag cacccaccac    1920

tgccctgggc ccctgtgaga ctgtgatggt tctttccacg ggtcaggccg agtctgaggc    1980

ctgagtgaca tgagggaggc agagcgggtc ccactgtccc cacactgg                 2028


<210> 142
<211> 981
<212> DNA
<213> Homo sapiens


<400> 142
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg     120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc     240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc     300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc     360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg     420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat     480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac     540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     960

ctctccctgt ctctgggtaa a                                               981


<210> 143
<211> 2028
<212> DNA
<213> Homo sapiens


<400> 143
agctttctgg ggcaggccgg gcctgacttt ggctgggggc agggaggggg ctaaggtgac      60

gcaggtggcg ccagccaggt gcacacccaa tgcccatgag cccagacact ggaccctgca     120

tggaccatcg cggatagaca agaaccgagg ggcctctgcg ccctgggccc agctctgtcc     180

cacaccgcgg tcacatggca ccacctctct tgcagcttcc accaagggcc catccgtctt     240

ccccctggcg ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt     300

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     360

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     420

gaccgtgccc tccagcagct tgggcacgaa gacctacacc tgcaacgtag atcacaagcc     480

cagcaacacc aaggtggaca agagagttgg tgagaggcca gcacagggag ggagggtgtc     540

tgctggaagc caggctcagc cctcctgcct ggacgcaccc cggctgtgca gccccagccc     600

agggcagcaa ggcatgcccc atctgtctcc tcacccggag gcctctgacc accccactca     660

tgctcaggga gagggtcttc tggatttttc caccaggctc ccggcaccac aggctggatg     720

cccctacccc aggccctgcg catacagggc aggtgctgcg ctcagacctg ccaagagcca     780

tatccgggag gaccctgccc ctgacctaag cccaccccaa aggccaaact ctccactccc     840

tcagctcaga caccttctct cctcccagat ctgagtaact cccaatcttc tctctgcaga     900

gtccaaatat ggtcccccat gcccatcatg cccaggtaag ccaacccagg cctcgccctc     960

cagctcaagg cgggacaggt gccctagagt agcctgcatc cagggacagg ccccagccgg    1020

gtgctgacgc atccacctcc atctcttcct cagcacctga gttcctgggg ggaccatcag    1080

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca    1140

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg    1200

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt    1260

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca    1320

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca    1380

aaggtgggac ccacggggtg cgagggccac acggacagag gccagctcgg cccaccctct    1440

gccctgggag tgaccgctgt gccaacctct gtccctacag ggcagccccg agagccacag    1500

gtgtacaccc tgcccccatc ccaggaggag atgaccaaga accaggtcag cctgacctgc    1560

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg    1620

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac    1680

agcaggctaa ccgtggacaa gagcaggtgg caggagggga atgtcttctc atgctccgtg    1740

atgcatgagg ctctgcacaa ccactacaca cagaagagcc tctccctgtc tctgggtaaa    1800

tgagtgccag ggccggcaag cccccgctcc ccgggctctc ggggtcgcgc gaggatgctt    1860

ggcacgtacc ccgtctacat acttcccagg cacccagcat ggaaataaag cacccaccac    1920

tgccctgggc ccctgtgaga ctgtgatggt tctttccacg ggtcaggccg agtctgaggc    1980

ctgagtgaca tgagggaggc agagcgggtc ccactgtccc cacactgg                 2028


<210> 144
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker sequence

<400> 144
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 145
<211> 990
<212> DNA
<213> Homo sapiens


<400> 145
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg     120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc     300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     960

cagaagagcc tctccctgtc tccgggtaaa                                      990


<210> 146
<211> 1596
<212> DNA
<213> Homo sapiens


<400> 146
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg     120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttggtgag     300

aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagcgctc ctgcctggac     360

gcatcccggc tatgcagccc cagtccaggg cagcaaggca ggccccgtct gcctcttcac     420

ccggaggcct ctgcccgccc cactcatgct cagggagagg gtcttctggc tttttcccca     480

ggctctgggc aggcacaggc taggtgcccc taacccaggc cctgcacaca aaggggcagg     540

tgctgggctc agacctgcca agagccatat ccgggaggac cctgcccctg acctaagccc     600

accccaaagg ccaaactctc cactccctca gctcggacac cttctctcct cccagattcc     660

agtaactccc aatcttctct ctgcagagcc caaatcttgt gacaaaactc acacatgccc     720

accgtgccca ggtaagccag cccaggcctc gccctccagc tcaaggcggg acaggtgccc     780

tagagtagcc tgcatccagg gacaggcccc agccgggtgc tgacacgtcc acctccatct     840

cttcctcagc acctgaactc ctggggggac cgtcagtctt cctcttcccc ccaaaaccca     900

aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg gacgtgagcc     960

acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca    1020

agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg    1080

tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc aacaaagccc    1140

tcccagcccc catcgagaaa accatctcca aagccaaagg tgggacccgt ggggtgcgag    1200

ggccacatgg acagaggccg gctcggccca ccctctgccc tgagagtgac cgctgtacca    1260

acctctgtcc ctacagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg    1320

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc    1380

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct    1440

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc    1500

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac    1560

tacacgcaga agagcctctc cctgtctccg ggtaaa                              1596


<210> 147
<211> 321
<212> DNA
<213> Homo sapiens


<400> 147
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct      60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag     120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac     180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag     240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag     300

agcttcaaca ggggagagtg t                                               321


<210> 148
<211> 255
<212> PRT
<213> Homo sapiens


<400> 148
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      
Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          
Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              
Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  
Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  
Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      
Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         
Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             
Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 
Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 
Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     
Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         
Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             
Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 

<210> 149
<211> 710
<212> PRT
<213> Homo sapiens


<400> 149
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Gly Ser 
            20                  25                  30          
Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Tyr Ser Ser Gly Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Val Pro His Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    450                 455                 460                 
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
465                 470                 475                 480 
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr 
                485                 490                 495     
Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            500                 505                 510         
Gly Ile Gly Ser Tyr Tyr Gly Tyr Thr Gly Tyr Ala Asp Ser Val Lys 
        515                 520                 525             
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
    530                 535                 540                 
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
545                 550                 555                 560 
Arg Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr Phe Asp Tyr Trp 
                565                 570                 575     
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
        595                 600                 605             
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    610                 615                 620                 
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
625                 630                 635                 640 
Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
                645                 650                 655     
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
            660                 665                 670         
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        675                 680                 685             
Cys Gln Gln Ser Val Pro His Tyr Pro Phe Thr Phe Gly Gln Gly Thr 
    690                 695                 700                 
Lys Leu Glu Ile Lys Arg 
705                 710 

<210> 150
<211> 2965
<212> DNA
<213> Homo sapiens


<400> 150
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt caccttttac ggttcttcta tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt atttactctt ctggtggtta cacatcttat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcggtgtt     300

cctcatggtt actttgacta ttggggccag ggaaccctgg tcaccgtctc ctcaggtgag     360

ttaacgtacg ctagcaagct ttctggggca ggccaggcct gaccttggct ttggggcagg     420

gagggggcta aggtgaggca ggtggcgcca gccaggtgca cacccaatgc ccatgagccc     480

agacactgga cgctgaacct cgcggacagt taagaaccca ggggcctctg cgccctgggc     540

ccagctctgt cccacaccgc ggtcacatgg caccacctct cttgcagcct ccaccaaggg     600

cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct     660

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc     720

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct     780

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt     840

gaatcacaag cccagcaaca ccaaggtgga caagaaagtt ggtgagaggc cagcacaggg     900

agggagggtg tctgctggaa gccaggctca gcgctcctgc ctggacgcat cccggctatg     960

cagccccagt ccagggcagc aaggcaggcc ccgtctgcct cttcacccgg aggcctctgc    1020

ccgccccact catgctcagg gagagggtct tctggctttt tccccaggct ctgggcaggc    1080

acaggctagg tgcccctaac ccaggccctg cacacaaagg ggcaggtgct gggctcagac    1140

ctgccaagag ccatatccgg gaggaccctg cccctgacct aagcccaccc caaaggccaa    1200

actctccact ccctcagctc ggacaccttc tctcctccca gattccagta actcccaatc    1260

ttctctctgc agagcccaaa tcttgtgaca aaactcacac atgcccaccg tgcccaggta    1320

agccagccca ggcctcgccc tccagctcaa ggcgggacag gtgccctaga gtagcctgca    1380

tccagggaca ggccccagcc gggtgctgac acgtccacct ccatctcttc ctcagcacct    1440

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    1500

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    1560

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    1620

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    1680

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    1740

gagaaaacca tctccaaagc caaaggtggg acccgtgggg tgcgagggcc acatggacag    1800

aggccggctc ggcccaccct ctgccctgag agtgaccgct gtaccaacct ctgtccctac    1860

agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa    1920

gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga    1980

gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc    2040

cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg    2100

gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag    2160

cctctccctg tctccgggta aaggaggagg aggaagcgga ggaggaggaa gcggaggagg    2220

aggaagcgag gtgcagctgc tcgagagcgg gggaggcttg gtacagcctg gggggtccct    2280

gcgcctctcc tgtgcagcca gcggattcac cttttcttct tactacatgg gttgggtccg    2340

ccaggctcca gggaaggggc tggagtgggt ctcaggtatt ggttcttact acggttacac    2400

aggttatgca gactccgtga agggccggtt caccatctcc cgtgacaatt ccaagaacac    2460

gctgtatctg caaatgaaca gcctgcgtgc cgaggacacg gctgtatatt attgtgcgcg    2520

cgcttactac gactacaact actactacgc ttactttgac tattggggcc agggaaccct    2580

ggtcaccgtc tcctcaggtg gaggcggttc aggcggaggt ggatccggcg gtggcggatc    2640

ggacatccag atgacccagt ctccatcctc cctgagcgca tctgtaggag accgcgtcac    2700

catcacttgc cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc    2760

agggaaagcc cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc    2820

acgtttcagt ggcagtggaa gcgggacaga tttcactctc accatcagca gtctgcaacc    2880

tgaagatttt gcaacttatt actgtcaaca gtctgttccg cactacccgt tcacttttgg    2940

ccaggggacc aagctggaga tcaaa                                          2965


<210> 151
<211> 709
<212> PRT
<213> Homo sapiens


<400> 151
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Asp Tyr Ala Ser Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr Met 
                485                 490                 495     
Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
            500                 505                 510         
Ile Gly Ser Tyr Tyr Gly Tyr Thr Gly Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
545                 550                 555                 560 
Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr Phe Asp Tyr Trp Gly 
                565                 570                 575     
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
        595                 600                 605             
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
    610                 615                 620                 
Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
625                 630                 635                 640 
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
                645                 650                 655     
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            660                 665                 670         
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
        675                 680                 685             
Gln Gln Ser Val Pro His Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys 
    690                 695                 700                 
Leu Glu Ile Lys Arg 
705                 

<210> 152
<211> 2962
<212> DNA
<213> Homo sapiens


<400> 152
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt ggttactaca tgtcttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctacgac     300

tacgcttcta tggactattg gggccaggga accctggtca ccgtctcctc aggtgagtta     360

acgtacgcta gcaagctttc tggggcaggc caggcctgac cttggctttg gggcagggag     420

ggggctaagg tgaggcaggt ggcgccagcc aggtgcacac ccaatgccca tgagcccaga     480

cactggacgc tgaacctcgc ggacagttaa gaacccaggg gcctctgcgc cctgggccca     540

gctctgtccc acaccgcggt cacatggcac cacctctctt gcagcctcca ccaagggccc     600

atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg     660

ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct     720

gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag     780

cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa     840

tcacaagccc agcaacacca aggtggacaa gaaagttggt gagaggccag cacagggagg     900

gagggtgtct gctggaagcc aggctcagcg ctcctgcctg gacgcatccc ggctatgcag     960

ccccagtcca gggcagcaag gcaggccccg tctgcctctt cacccggagg cctctgcccg    1020

ccccactcat gctcagggag agggtcttct ggctttttcc ccaggctctg ggcaggcaca    1080

ggctaggtgc ccctaaccca ggccctgcac acaaaggggc aggtgctggg ctcagacctg    1140

ccaagagcca tatccgggag gaccctgccc ctgacctaag cccaccccaa aggccaaact    1200

ctccactccc tcagctcgga caccttctct cctcccagat tccagtaact cccaatcttc    1260

tctctgcaga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc ccaggtaagc    1320

cagcccaggc ctcgccctcc agctcaaggc gggacaggtg ccctagagta gcctgcatcc    1380

agggacaggc cccagccggg tgctgacacg tccacctcca tctcttcctc agcacctgaa    1440

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc    1500

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc    1560

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag    1620

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    1680

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag    1740

aaaaccatct ccaaagccaa aggtgggacc cgtggggtgc gagggccaca tggacagagg    1800

ccggctcggc ccaccctctg ccctgagagt gaccgctgta ccaacctctg tccctacagg    1860

gcagccccga gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa    1920

ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg    1980

ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga    2040

cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa    2100

cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct    2160

ctccctgtct ccgggtaaag gaggaggagg aagcggagga ggaggaagcg gaggaggagg    2220

aagcgaggtg cagctgctcg agagcggggg aggcttggta cagcctgggg ggtccctgcg    2280

cctctcctgt gcagccagcg gattcacctt ttcttcttac tacatgggtt gggtccgcca    2340

ggctccaggg aaggggctgg agtgggtctc aggtattggt tcttactacg gttacacagg    2400

ttatgcagac tccgtgaagg gccggttcac catctcccgt gacaattcca agaacacgct    2460

gtatctgcaa atgaacagcc tgcgtgccga ggacacggct gtatattatt gtgcgcgcgc    2520

ttactacgac tacaactact actacgctta ctttgactat tggggccagg gaaccctggt    2580

caccgtctcc tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcgga    2640

catccagatg acccagtctc catcctccct gagcgcatct gtaggagacc gcgtcaccat    2700

cacttgccgg gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg    2760

gaaagcccct aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcacg    2820

tttcagtggc agtggaagcg ggacagattt cactctcacc atcagcagtc tgcaacctga    2880

agattttgca acttattact gtcaacagtc tgttccgcac tacccgttca cttttggcca    2940

ggggaccaag ctggagatca aa                                             2962


<210> 153
<211> 710
<212> PRT
<213> Homo sapiens


<400> 153
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Tyr Tyr Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Phe Pro His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    450                 455                 460                 
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
465                 470                 475                 480 
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr 
                485                 490                 495     
Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            500                 505                 510         
Gly Ile Gly Ser Tyr Tyr Gly Tyr Thr Gly Tyr Ala Asp Ser Val Lys 
        515                 520                 525             
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
    530                 535                 540                 
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
545                 550                 555                 560 
Arg Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr Phe Asp Tyr Trp 
                565                 570                 575     
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
        595                 600                 605             
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    610                 615                 620                 
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
625                 630                 635                 640 
Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
                645                 650                 655     
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
            660                 665                 670         
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        675                 680                 685             
Cys Gln Gln Ser Val Pro His Tyr Pro Phe Thr Phe Gly Gln Gly Thr 
    690                 695                 700                 
Lys Leu Glu Ile Lys Arg 
705                 710 

<210> 154
<211> 2965
<212> DNA
<213> Homo sapiens


<400> 154
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagt ggttcttcta tgtcttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatct atttcttact acggtggtta cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctacttc     300

ccgcattact actttgacta ttggggccag ggaaccctgg tcaccgtctc ctcaggtgag     360

ttaacgtacg ctagcaagct ttctggggca ggccaggcct gaccttggct ttggggcagg     420

gagggggcta aggtgaggca ggtggcgcca gccaggtgca cacccaatgc ccatgagccc     480

agacactgga cgctgaacct cgcggacagt taagaaccca ggggcctctg cgccctgggc     540

ccagctctgt cccacaccgc ggtcacatgg caccacctct cttgcagcct ccaccaaggg     600

cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct     660

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc     720

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct     780

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt     840

gaatcacaag cccagcaaca ccaaggtgga caagaaagtt ggtgagaggc cagcacaggg     900

agggagggtg tctgctggaa gccaggctca gcgctcctgc ctggacgcat cccggctatg     960

cagccccagt ccagggcagc aaggcaggcc ccgtctgcct cttcacccgg aggcctctgc    1020

ccgccccact catgctcagg gagagggtct tctggctttt tccccaggct ctgggcaggc    1080

acaggctagg tgcccctaac ccaggccctg cacacaaagg ggcaggtgct gggctcagac    1140

ctgccaagag ccatatccgg gaggaccctg cccctgacct aagcccaccc caaaggccaa    1200

actctccact ccctcagctc ggacaccttc tctcctccca gattccagta actcccaatc    1260

ttctctctgc agagcccaaa tcttgtgaca aaactcacac atgcccaccg tgcccaggta    1320

agccagccca ggcctcgccc tccagctcaa ggcgggacag gtgccctaga gtagcctgca    1380

tccagggaca ggccccagcc gggtgctgac acgtccacct ccatctcttc ctcagcacct    1440

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    1500

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    1560

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    1620

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    1680

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    1740

gagaaaacca tctccaaagc caaaggtggg acccgtgggg tgcgagggcc acatggacag    1800

aggccggctc ggcccaccct ctgccctgag agtgaccgct gtaccaacct ctgtccctac    1860

agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa    1920

gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga    1980

gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc    2040

cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg    2100

gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag    2160

cctctccctg tctccgggta aaggaggagg aggaagcgga ggaggaggaa gcggaggagg    2220

aggaagcgag gtgcagctgc tcgagagcgg gggaggcttg gtacagcctg gggggtccct    2280

gcgcctctcc tgtgcagcca gcggattcac cttttcttct tactacatgg gttgggtccg    2340

ccaggctcca gggaaggggc tggagtgggt ctcaggtatt ggttcttact acggttacac    2400

aggttatgca gactccgtga agggccggtt caccatctcc cgtgacaatt ccaagaacac    2460

gctgtatctg caaatgaaca gcctgcgtgc cgaggacacg gctgtatatt attgtgcgcg    2520

cgcttactac gactacaact actactacgc ttactttgac tattggggcc agggaaccct    2580

ggtcaccgtc tcctcaggtg gaggcggttc aggcggaggt ggatccggcg gtggcggatc    2640

ggacatccag atgacccagt ctccatcctc cctgagcgca tctgtaggag accgcgtcac    2700

catcacttgc cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc    2760

agggaaagcc cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc    2820

acgtttcagt ggcagtggaa gcgggacaga tttcactctc accatcagca gtctgcaacc    2880

tgaagatttt gcaacttatt actgtcaaca gtctgttccg cactacccgt tcacttttgg    2940

ccaggggacc aagctggaga tcaaa                                          2965


<210> 155
<211> 709
<212> PRT
<213> Homo sapiens


<400> 155
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Pro Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Asp Tyr Tyr Trp Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        435                 440                 445             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 
Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr Met 
                485                 490                 495     
Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
            500                 505                 510         
Ile Gly Ser Tyr Tyr Gly Tyr Thr Gly Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
545                 550                 555                 560 
Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr Phe Asp Tyr Trp Gly 
                565                 570                 575     
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
        595                 600                 605             
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
    610                 615                 620                 
Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
625                 630                 635                 640 
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
                645                 650                 655     
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            660                 665                 670         
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
        675                 680                 685             
Gln Gln Ser Val Pro His Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys 
    690                 695                 700                 
Leu Glu Ile Lys Arg 
705                 

<210> 156
<211> 2962
<212> DNA
<213> Homo sapiens


<400> 156
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt ggttactaca tgtcttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatac attcctggtt ctggtggttc tacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctacgac     300

tactactgga tggactattg gggccaggga accctggtca ccgtctcctc aggtgagtta     360

acgtacgcta gcaagctttc tggggcaggc caggcctgac cttggctttg gggcagggag     420

ggggctaagg tgaggcaggt ggcgccagcc aggtgcacac ccaatgccca tgagcccaga     480

cactggacgc tgaacctcgc ggacagttaa gaacccaggg gcctctgcgc cctgggccca     540

gctctgtccc acaccgcggt cacatggcac cacctctctt gcagcctcca ccaagggccc     600

atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg     660

ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct     720

gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag     780

cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa     840

tcacaagccc agcaacacca aggtggacaa gaaagttggt gagaggccag cacagggagg     900

gagggtgtct gctggaagcc aggctcagcg ctcctgcctg gacgcatccc ggctatgcag     960

ccccagtcca gggcagcaag gcaggccccg tctgcctctt cacccggagg cctctgcccg    1020

ccccactcat gctcagggag agggtcttct ggctttttcc ccaggctctg ggcaggcaca    1080

ggctaggtgc ccctaaccca ggccctgcac acaaaggggc aggtgctggg ctcagacctg    1140

ccaagagcca tatccgggag gaccctgccc ctgacctaag cccaccccaa aggccaaact    1200

ctccactccc tcagctcgga caccttctct cctcccagat tccagtaact cccaatcttc    1260

tctctgcaga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc ccaggtaagc    1320

cagcccaggc ctcgccctcc agctcaaggc gggacaggtg ccctagagta gcctgcatcc    1380

agggacaggc cccagccggg tgctgacacg tccacctcca tctcttcctc agcacctgaa    1440

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc    1500

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc    1560

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag    1620

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg    1680

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag    1740

aaaaccatct ccaaagccaa aggtgggacc cgtggggtgc gagggccaca tggacagagg    1800

ccggctcggc ccaccctctg ccctgagagt gaccgctgta ccaacctctg tccctacagg    1860

gcagccccga gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa    1920

ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg    1980

ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga    2040

cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa    2100

cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct    2160

ctccctgtct ccgggtaaag gaggaggagg aagcggagga ggaggaagcg gaggaggagg    2220

aagcgaggtg cagctgctcg agagcggggg aggcttggta cagcctgggg ggtccctgcg    2280

cctctcctgt gcagccagcg gattcacctt ttcttcttac tacatgggtt gggtccgcca    2340

ggctccaggg aaggggctgg agtgggtctc aggtattggt tcttactacg gttacacagg    2400

ttatgcagac tccgtgaagg gccggttcac catctcccgt gacaattcca agaacacgct    2460

gtatctgcaa atgaacagcc tgcgtgccga ggacacggct gtatattatt gtgcgcgcgc    2520

ttactacgac tacaactact actacgctta ctttgactat tggggccagg gaaccctggt    2580

caccgtctcc tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcgga    2640

catccagatg acccagtctc catcctccct gagcgcatct gtaggagacc gcgtcaccat    2700

cacttgccgg gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg    2760

gaaagcccct aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcacg    2820

tttcagtggc agtggaagcg ggacagattt cactctcacc atcagcagtc tgcaacctga    2880

agattttgca acttattact gtcaacagtc tgttccgcac tacccgttca cttttggcca    2940

ggggaccaag ctggagatca aa                                             2962


<210> 157
<211> 708
<212> PRT
<213> Homo sapiens


<400> 157
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Ser Tyr Tyr Ser Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
        435                 440                 445             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    450                 455                 460                 
Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
465                 470                 475                 480 
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr Met Gly 
                485                 490                 495     
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
            500                 505                 510         
Gly Ser Tyr Tyr Gly Tyr Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg 
        515                 520                 525             
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    530                 535                 540                 
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala 
545                 550                 555                 560 
Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr Phe Asp Tyr Trp Gly Gln 
                565                 570                 575     
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
        595                 600                 605             
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
    610                 615                 620                 
Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
625                 630                 635                 640 
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
                645                 650                 655     
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            660                 665                 670         
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
        675                 680                 685             
Gln Ser Val Pro His Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu 
    690                 695                 700                 
Glu Ile Lys Arg 
705             

<210> 158
<211> 2959
<212> DNA
<213> Homo sapiens


<400> 158
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatac atttcttact actctggtta cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcggttac     300

ggttacttgg actattgggg ccagggaacc ctggtcaccg tctcctcagg tgagttaacg     360

tacgctagca agctttctgg ggcaggccag gcctgacctt ggctttgggg cagggagggg     420

gctaaggtga ggcaggtggc gccagccagg tgcacaccca atgcccatga gcccagacac     480

tggacgctga acctcgcgga cagttaagaa cccaggggcc tctgcgccct gggcccagct     540

ctgtcccaca ccgcggtcac atggcaccac ctctcttgca gcctccacca agggcccatc     600

ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg     660

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac     720

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag     780

cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca     840

caagcccagc aacaccaagg tggacaagaa agttggtgag aggccagcac agggagggag     900

ggtgtctgct ggaagccagg ctcagcgctc ctgcctggac gcatcccggc tatgcagccc     960

cagtccaggg cagcaaggca ggccccgtct gcctcttcac ccggaggcct ctgcccgccc    1020

cactcatgct cagggagagg gtcttctggc tttttcccca ggctctgggc aggcacaggc    1080

taggtgcccc taacccaggc cctgcacaca aaggggcagg tgctgggctc agacctgcca    1140

agagccatat ccgggaggac cctgcccctg acctaagccc accccaaagg ccaaactctc    1200

cactccctca gctcggacac cttctctcct cccagattcc agtaactccc aatcttctct    1260

ctgcagagcc caaatcttgt gacaaaactc acacatgccc accgtgccca ggtaagccag    1320

cccaggcctc gccctccagc tcaaggcggg acaggtgccc tagagtagcc tgcatccagg    1380

gacaggcccc agccgggtgc tgacacgtcc acctccatct cttcctcagc acctgaactc    1440

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc    1500

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag    1560

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag    1620

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg    1680

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa    1740

accatctcca aagccaaagg tgggacccgt ggggtgcgag ggccacatgg acagaggccg    1800

gctcggccca ccctctgccc tgagagtgac cgctgtacca acctctgtcc ctacagggca    1860

gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca    1920

ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga    1980

gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg    2040

ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt    2100

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc    2160

cctgtctccg ggtaaaggag gaggaggaag cggaggagga ggaagcggag gaggaggaag    2220

cgaggtgcag ctgctcgaga gcgggggagg cttggtacag cctggggggt ccctgcgcct    2280

ctcctgtgca gccagcggat tcaccttttc ttcttactac atgggttggg tccgccaggc    2340

tccagggaag gggctggagt gggtctcagg tattggttct tactacggtt acacaggtta    2400

tgcagactcc gtgaagggcc ggttcaccat ctcccgtgac aattccaaga acacgctgta    2460

tctgcaaatg aacagcctgc gtgccgagga cacggctgta tattattgtg cgcgcgctta    2520

ctacgactac aactactact acgcttactt tgactattgg ggccagggaa ccctggtcac    2580

cgtctcctca ggtggaggcg gttcaggcgg aggtggatcc ggcggtggcg gatcggacat    2640

ccagatgacc cagtctccat cctccctgag cgcatctgta ggagaccgcg tcaccatcac    2700

ttgccgggca agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa    2760

agcccctaag ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcacgttt    2820

cagtggcagt ggaagcggga cagatttcac tctcaccatc agcagtctgc aacctgaaga    2880

ttttgcaact tattactgtc aacagtctgt tccgcactac ccgttcactt ttggccaggg    2940

gaccaagctg gagatcaaa                                                 2959


<210> 159
<211> 716
<212> PRT
<213> Homo sapiens


<400> 159
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Tyr Ser His Gly Tyr Tyr Val Tyr Gly Thr Leu Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             
Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
465                 470                 475                 480 
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                485                 490                 495     
Thr Phe Ser Ser Tyr Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys 
            500                 505                 510         
Gly Leu Glu Trp Val Ser Gly Ile Gly Ser Tyr Tyr Gly Tyr Thr Gly 
        515                 520                 525             
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    530                 535                 540                 
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
545                 550                 555                 560 
Ala Val Tyr Tyr Cys Ala Arg Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr 
                565                 570                 575     
Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            580                 585                 590         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        595                 600                 605             
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    610                 615                 620                 
Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
625                 630                 635                 640 
Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
                645                 650                 655     
Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
            660                 665                 670         
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        675                 680                 685             
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Val Pro His Tyr Pro Phe 
    690                 695                 700                 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
705                 710                 715     

<210> 160
<211> 2983
<212> DNA
<213> Homo sapiens


<400> 160
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctactac     300

tactctcatg gttactacgt ttacggtact ttggactatt ggggccaggg aaccctggtc     360

accgtctcct caggtgagtt aacgtacgct agcaagcttt ctggggcagg ccaggcctga     420

ccttggcttt ggggcaggga gggggctaag gtgaggcagg tggcgccagc caggtgcaca     480

cccaatgccc atgagcccag acactggacg ctgaacctcg cggacagtta agaacccagg     540

ggcctctgcg ccctgggccc agctctgtcc cacaccgcgg tcacatggca ccacctctct     600

tgcagcctcc accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc     660

tgggggcaca gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt     720

gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc     780

ctcaggactc tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca     840

gacctacatc tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttgg     900

tgagaggcca gcacagggag ggagggtgtc tgctggaagc caggctcagc gctcctgcct     960

ggacgcatcc cggctatgca gccccagtcc agggcagcaa ggcaggcccc gtctgcctct    1020

tcacccggag gcctctgccc gccccactca tgctcaggga gagggtcttc tggctttttc    1080

cccaggctct gggcaggcac aggctaggtg cccctaaccc aggccctgca cacaaagggg    1140

caggtgctgg gctcagacct gccaagagcc atatccggga ggaccctgcc cctgacctaa    1200

gcccacccca aaggccaaac tctccactcc ctcagctcgg acaccttctc tcctcccaga    1260

ttccagtaac tcccaatctt ctctctgcag agcccaaatc ttgtgacaaa actcacacat    1320

gcccaccgtg cccaggtaag ccagcccagg cctcgccctc cagctcaagg cgggacaggt    1380

gccctagagt agcctgcatc cagggacagg ccccagccgg gtgctgacac gtccacctcc    1440

atctcttcct cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa    1500

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg    1560

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat    1620

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc    1680

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa    1740

gccctcccag cccccatcga gaaaaccatc tccaaagcca aaggtgggac ccgtggggtg    1800

cgagggccac atggacagag gccggctcgg cccaccctct gccctgagag tgaccgctgt    1860

accaacctct gtccctacag ggcagccccg agaaccacag gtgtacaccc tgcccccatc    1920

ccgggatgag ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc    1980

cagcgacatc gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac    2040

gcctcccgtg ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa    2100

gagcaggtgg cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa    2160

ccactacacg cagaagagcc tctccctgtc tccgggtaaa ggaggaggag gaagcggagg    2220

aggaggaagc ggaggaggag gaagcgaggt gcagctgctc gagagcgggg gaggcttggt    2280

acagcctggg gggtccctgc gcctctcctg tgcagccagc ggattcacct tttcttctta    2340

ctacatgggt tgggtccgcc aggctccagg gaaggggctg gagtgggtct caggtattgg    2400

ttcttactac ggttacacag gttatgcaga ctccgtgaag ggccggttca ccatctcccg    2460

tgacaattcc aagaacacgc tgtatctgca aatgaacagc ctgcgtgccg aggacacggc    2520

tgtatattat tgtgcgcgcg cttactacga ctacaactac tactacgctt actttgacta    2580

ttggggccag ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg    2640

atccggcggt ggcggatcgg acatccagat gacccagtct ccatcctccc tgagcgcatc    2700

tgtaggagac cgcgtcacca tcacttgccg ggcaagtcag agcattagca gctatttaaa    2760

ttggtatcag cagaaaccag ggaaagcccc taagctcctg atctatgctg catccagttt    2820

gcaaagtggg gtcccatcac gtttcagtgg cagtggaagc gggacagatt tcactctcac    2880

catcagcagt ctgcaacctg aagattttgc aacttattac tgtcaacagt ctgttccgca    2940

ctacccgttc acttttggcc aggggaccaa gctggagatc aaa                      2983


<210> 161
<211> 714
<212> PRT
<213> Homo sapiens


<400> 161
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          
Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Gly Tyr Ser Gly Tyr Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Phe His Asp Tyr Ala Ala Tyr Ser Leu Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 
Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
465                 470                 475                 480 
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                485                 490                 495     
Ser Ser Tyr Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            500                 505                 510         
Glu Trp Val Ser Gly Ile Gly Ser Tyr Tyr Gly Tyr Thr Gly Tyr Ala 
        515                 520                 525             
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    530                 535                 540                 
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
545                 550                 555                 560 
Tyr Tyr Cys Ala Arg Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr 
                565                 570                 575     
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
            580                 585                 590         
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
        595                 600                 605             
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    610                 615                 620                 
Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
625                 630                 635                 640 
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
                645                 650                 655     
Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            660                 665                 670         
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
        675                 680                 685             
Ala Thr Tyr Tyr Cys Gln Gln Ser Val Pro His Tyr Pro Phe Thr Phe 
    690                 695                 700                 
Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
705                 710                 

<210> 162
<211> 2977
<212> DNA
<213> Homo sapiens


<400> 162
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt caccttttct ggttactcta tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt attggttact ctggttacgg tacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctactac     300

ttccatgact acgctgctta ctctttggac tattggggcc agggaaccct ggtcaccgtc     360

tcctcaggtg agttaacgta cgctagcaag ctttctgggg caggccaggc ctgaccttgg     420

ctttggggca gggagggggc taaggtgagg caggtggcgc cagccaggtg cacacccaat     480

gcccatgagc ccagacactg gacgctgaac ctcgcggaca gttaagaacc caggggcctc     540

tgcgccctgg gcccagctct gtcccacacc gcggtcacat ggcaccacct ctcttgcagc     600

ctccaccaag ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg     660

cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg     720

gaactcaggc gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg     780

actctactcc ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta     840

catctgcaac gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttggtgagag     900

gccagcacag ggagggaggg tgtctgctgg aagccaggct cagcgctcct gcctggacgc     960

atcccggcta tgcagcccca gtccagggca gcaaggcagg ccccgtctgc ctcttcaccc    1020

ggaggcctct gcccgcccca ctcatgctca gggagagggt cttctggctt tttccccagg    1080

ctctgggcag gcacaggcta ggtgccccta acccaggccc tgcacacaaa ggggcaggtg    1140

ctgggctcag acctgccaag agccatatcc gggaggaccc tgcccctgac ctaagcccac    1200

cccaaaggcc aaactctcca ctccctcagc tcggacacct tctctcctcc cagattccag    1260

taactcccaa tcttctctct gcagagccca aatcttgtga caaaactcac acatgcccac    1320

cgtgcccagg taagccagcc caggcctcgc cctccagctc aaggcgggac aggtgcccta    1380

gagtagcctg catccaggga caggccccag ccgggtgctg acacgtccac ctccatctct    1440

tcctcagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag    1500

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac    1560

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag    1620

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc    1680

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc    1740

ccagccccca tcgagaaaac catctccaaa gccaaaggtg ggacccgtgg ggtgcgaggg    1800

ccacatggac agaggccggc tcggcccacc ctctgccctg agagtgaccg ctgtaccaac    1860

ctctgtccct acagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga    1920

tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga    1980

catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc    2040

cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag    2100

gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta    2160

cacgcagaag agcctctccc tgtctccggg taaaggagga ggaggaagcg gaggaggagg    2220

aagcggagga ggaggaagcg aggtgcagct gctcgagagc gggggaggct tggtacagcc    2280

tggggggtcc ctgcgcctct cctgtgcagc cagcggattc accttttctt cttactacat    2340

gggttgggtc cgccaggctc cagggaaggg gctggagtgg gtctcaggta ttggttctta    2400

ctacggttac acaggttatg cagactccgt gaagggccgg ttcaccatct cccgtgacaa    2460

ttccaagaac acgctgtatc tgcaaatgaa cagcctgcgt gccgaggaca cggctgtata    2520

ttattgtgcg cgcgcttact acgactacaa ctactactac gcttactttg actattgggg    2580

ccagggaacc ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggatccgg    2640

cggtggcgga tcggacatcc agatgaccca gtctccatcc tccctgagcg catctgtagg    2700

agaccgcgtc accatcactt gccgggcaag tcagagcatt agcagctatt taaattggta    2760

tcagcagaaa ccagggaaag cccctaagct cctgatctat gctgcatcca gtttgcaaag    2820

tggggtccca tcacgtttca gtggcagtgg aagcgggaca gatttcactc tcaccatcag    2880

cagtctgcaa cctgaagatt ttgcaactta ttactgtcaa cagtctgttc cgcactaccc    2940

gttcactttt ggccagggga ccaagctgga gatcaaa                             2977


<210> 163
<211> 710
<212> PRT
<213> Homo sapiens


<400> 163
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Ser 
            20                  25                  30          
Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Gly Tyr Tyr Ser Tyr Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Pro His His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    450                 455                 460                 
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
465                 470                 475                 480 
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr 
                485                 490                 495     
Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            500                 505                 510         
Gly Ile Gly Ser Tyr Tyr Gly Tyr Thr Gly Tyr Ala Asp Ser Val Lys 
        515                 520                 525             
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
    530                 535                 540                 
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
545                 550                 555                 560 
Arg Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr Phe Asp Tyr Trp 
                565                 570                 575     
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
        595                 600                 605             
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    610                 615                 620                 
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
625                 630                 635                 640 
Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
                645                 650                 655     
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
            660                 665                 670         
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        675                 680                 685             
Cys Gln Gln Ser Val Pro His Tyr Pro Phe Thr Phe Gly Gln Gly Thr 
    690                 695                 700                 
Lys Leu Glu Ile Lys Arg 
705                 710 

<210> 164
<211> 2965
<212> DNA
<213> Homo sapiens


<400> 164
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt tcttcttcta tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt attggttact actcttactc tacatcttat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcggttac     300

ccgcatcatt actttgacta ttggggccag ggaaccctgg tcaccgtctc ctcaggtgag     360

ttaacgtacg ctagcaagct ttctggggca ggccaggcct gaccttggct ttggggcagg     420

gagggggcta aggtgaggca ggtggcgcca gccaggtgca cacccaatgc ccatgagccc     480

agacactgga cgctgaacct cgcggacagt taagaaccca ggggcctctg cgccctgggc     540

ccagctctgt cccacaccgc ggtcacatgg caccacctct cttgcagcct ccaccaaggg     600

cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct     660

gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc     720

cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct     780

cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt     840

gaatcacaag cccagcaaca ccaaggtgga caagaaagtt ggtgagaggc cagcacaggg     900

agggagggtg tctgctggaa gccaggctca gcgctcctgc ctggacgcat cccggctatg     960

cagccccagt ccagggcagc aaggcaggcc ccgtctgcct cttcacccgg aggcctctgc    1020

ccgccccact catgctcagg gagagggtct tctggctttt tccccaggct ctgggcaggc    1080

acaggctagg tgcccctaac ccaggccctg cacacaaagg ggcaggtgct gggctcagac    1140

ctgccaagag ccatatccgg gaggaccctg cccctgacct aagcccaccc caaaggccaa    1200

actctccact ccctcagctc ggacaccttc tctcctccca gattccagta actcccaatc    1260

ttctctctgc agagcccaaa tcttgtgaca aaactcacac atgcccaccg tgcccaggta    1320

agccagccca ggcctcgccc tccagctcaa ggcgggacag gtgccctaga gtagcctgca    1380

tccagggaca ggccccagcc gggtgctgac acgtccacct ccatctcttc ctcagcacct    1440

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg    1500

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag    1560

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg    1620

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac    1680

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc    1740

gagaaaacca tctccaaagc caaaggtggg acccgtgggg tgcgagggcc acatggacag    1800

aggccggctc ggcccaccct ctgccctgag agtgaccgct gtaccaacct ctgtccctac    1860

agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa    1920

gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga    1980

gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc    2040

cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg    2100

gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag    2160

cctctccctg tctccgggta aaggaggagg aggaagcgga ggaggaggaa gcggaggagg    2220

aggaagcgag gtgcagctgc tcgagagcgg gggaggcttg gtacagcctg gggggtccct    2280

gcgcctctcc tgtgcagcca gcggattcac cttttcttct tactacatgg gttgggtccg    2340

ccaggctcca gggaaggggc tggagtgggt ctcaggtatt ggttcttact acggttacac    2400

aggttatgca gactccgtga agggccggtt caccatctcc cgtgacaatt ccaagaacac    2460

gctgtatctg caaatgaaca gcctgcgtgc cgaggacacg gctgtatatt attgtgcgcg    2520

cgcttactac gactacaact actactacgc ttactttgac tattggggcc agggaaccct    2580

ggtcaccgtc tcctcaggtg gaggcggttc aggcggaggt ggatccggcg gtggcggatc    2640

ggacatccag atgacccagt ctccatcctc cctgagcgca tctgtaggag accgcgtcac    2700

catcacttgc cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc    2760

agggaaagcc cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc    2820

acgtttcagt ggcagtggaa gcgggacaga tttcactctc accatcagca gtctgcaacc    2880

tgaagatttt gcaacttatt actgtcaaca gtctgttccg cactacccgt tcacttttgg    2940

ccaggggacc aagctggaga tcaaa                                          2965


<210> 165
<211> 214
<212> PRT
<213> Homo sapiens


<400> 165
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 166
<211> 1007
<212> DNA
<213> Homo sapiens


<400> 166
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag agttacagta ccccttatac ttttggccag     300

gggaccaagc tggagatcaa acgtgagtcg tacgctagca agcttgatat cgaattctaa     360

actctgaggg ggtcggatga cgtggccatt ctttgcctaa agcattgagt ttactgcaag     420

gtcagaaaag catgcaaagc cctcagaatg gctgcaaaga gctccaacaa aacaatttag     480

aactttatta aggaataggg ggaagctagg aagaaactca aaacatcaag attttaaata     540

cgcttcttgg tctccttgct ataattatct gggataagca tgctgttttc tgtctgtccc     600

taacatgccc tgtgattatc cgcaaacaac acacccaagg gcagaacttt gttacttaaa     660

caccatcctg tttgcttctt tcctcaggaa ctgtggctgc accatctgtc ttcatcttcc     720

cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact     780

tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact     840

cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc     900

tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc     960

agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt                  1007


<210> 167
<211> 215
<212> PRT
<213> Homo sapiens


<400> 167
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Trp Tyr Gly Leu 
                85                  90                  95      
Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 168
<211> 1010
<212> DNA
<213> Homo sapiens


<400> 168
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tactactggt acggtctgtc cacttttggc     300

caggggacca agctggagat caaacgtgag tcgtacgcta gcaagcttga tatcgaattc     360

taaactctga gggggtcgga tgacgtggcc attctttgcc taaagcattg agtttactgc     420

aaggtcagaa aagcatgcaa agccctcaga atggctgcaa agagctccaa caaaacaatt     480

tagaacttta ttaaggaata gggggaagct aggaagaaac tcaaaacatc aagattttaa     540

atacgcttct tggtctcctt gctataatta tctgggataa gcatgctgtt ttctgtctgt     600

ccctaacatg ccctgtgatt atccgcaaac aacacaccca agggcagaac tttgttactt     660

aaacaccatc ctgtttgctt ctttcctcag gaactgtggc tgcaccatct gtcttcatct     720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata     780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta     840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca     900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     960

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt               1010


<210> 169
<211> 215
<212> PRT
<213> Homo sapiens


<400> 169
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Gly Ser Tyr Pro 
                85                  90                  95      
His Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 170
<211> 1010
<212> DNA
<213> Homo sapiens


<400> 170
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtcatggtt cttacccgca cacttttggc     300

caggggacca agctggagat caaacgtgag tcgtacgcta gcaagcttga tatcgaattc     360

taaactctga gggggtcgga tgacgtggcc attctttgcc taaagcattg agtttactgc     420

aaggtcagaa aagcatgcaa agccctcaga atggctgcaa agagctccaa caaaacaatt     480

tagaacttta ttaaggaata gggggaagct aggaagaaac tcaaaacatc aagattttaa     540

atacgcttct tggtctcctt gctataatta tctgggataa gcatgctgtt ttctgtctgt     600

ccctaacatg ccctgtgatt atccgcaaac aacacaccca agggcagaac tttgttactt     660

aaacaccatc ctgtttgctt ctttcctcag gaactgtggc tgcaccatct gtcttcatct     720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata     780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta     840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca     900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     960

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt               1010


<210> 171
<211> 213
<212> PRT
<213> Homo sapiens


<400> 171
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Leu Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210> 172
<211> 1004
<212> DNA
<213> Homo sapiens


<400> 172
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tacggttctc tgctcacttt tggccagggg     300

accaagctgg agatcaaacg tgagtcgtac gctagcaagc ttgatatcga attctaaact     360

ctgagggggt cggatgacgt ggccattctt tgcctaaagc attgagttta ctgcaaggtc     420

agaaaagcat gcaaagccct cagaatggct gcaaagagct ccaacaaaac aatttagaac     480

tttattaagg aataggggga agctaggaag aaactcaaaa catcaagatt ttaaatacgc     540

ttcttggtct ccttgctata attatctggg ataagcatgc tgttttctgt ctgtccctaa     600

catgccctgt gattatccgc aaacaacaca cccaagggca gaactttgtt acttaaacac     660

catcctgttt gcttctttcc tcaggaactg tggctgcacc atctgtcttc atcttcccgc     720

catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct     780

atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc     840

aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga     900

cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc acccatcagg     960

gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt                     1004


<210> 173
<211> 215
<212> PRT
<213> Homo sapiens


<400> 173
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Asp Ser Leu 
                85                  90                  95      
Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 174
<211> 1010
<212> DNA
<213> Homo sapiens


<400> 174
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tacggttctg attctctgct cacttttggc     300

caggggacca agctggagat caaacgtgag tcgtacgcta gcaagcttga tatcgaattc     360

taaactctga gggggtcgga tgacgtggcc attctttgcc taaagcattg agtttactgc     420

aaggtcagaa aagcatgcaa agccctcaga atggctgcaa agagctccaa caaaacaatt     480

tagaacttta ttaaggaata gggggaagct aggaagaaac tcaaaacatc aagattttaa     540

atacgcttct tggtctcctt gctataatta tctgggataa gcatgctgtt ttctgtctgt     600

ccctaacatg ccctgtgatt atccgcaaac aacacaccca agggcagaac tttgttactt     660

aaacaccatc ctgtttgctt ctttcctcag gaactgtggc tgcaccatct gtcttcatct     720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata     780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta     840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca     900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     960

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt               1010


<210> 175
<211> 981
<212> DNA
<213> Homo sapiens


<400> 175
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg     120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc     240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc     300

aaatatggtc ccccatgccc accttgccca gcacctgagt tcctgggggg accatcagtc     360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg     420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat     480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac     540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     960

ctctccctgt ctctgggtaa a                                               981


<210> 176
<211> 2028
<212> DNA
<213> Homo sapiens


<400> 176
agctttctgg ggcaggccgg gcctgacttt ggctgggggc agggaggggg ctaaggtgac      60

gcaggtggcg ccagccaggt gcacacccaa tgcccatgag cccagacact ggaccctgca     120

tggaccatcg cggatagaca agaaccgagg ggcctctgcg ccctgggccc agctctgtcc     180

cacaccgcgg tcacatggca ccacctctct tgcagcttcc accaagggcc catccgtctt     240

ccccctggcg ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt     300

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     360

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     420

gaccgtgccc tccagcagct tgggcacgaa gacctacacc tgcaacgtag atcacaagcc     480

cagcaacacc aaggtggaca agagagttgg tgagaggcca gcacagggag ggagggtgtc     540

tgctggaagc caggctcagc cctcctgcct ggacgcaccc cggctgtgca gccccagccc     600

agggcagcaa ggcatgcccc atctgtctcc tcacccggag gcctctgacc accccactca     660

tgctcaggga gagggtcttc tggatttttc caccaggctc ccggcaccac aggctggatg     720

cccctacccc aggccctgcg catacagggc aggtgctgcg ctcagacctg ccaagagcca     780

tatccgggag gaccctgccc ctgacctaag cccaccccaa aggccaaact ctccactccc     840

tcagctcaga caccttctct cctcccagat ctgagtaact cccaatcttc tctctgcaga     900

gtccaaatat ggtcccccat gcccaccttg cccaggtaag ccaacccagg cctcgccctc     960

cagctcaagg cgggacaggt gccctagagt agcctgcatc cagggacagg ccccagccgg    1020

gtgctgacgc atccacctcc atctcttcct cagcacctga gttcctgggg ggaccatcag    1080

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca    1140

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg    1200

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt    1260

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca    1320

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca    1380

aaggtgggac ccacggggtg cgagggccac acggacagag gccagctcgg cccaccctct    1440

gccctgggag tgaccgctgt gccaacctct gtccctacag ggcagccccg agagccacag    1500

gtgtacaccc tgcccccatc ccaggaggag atgaccaaga accaggtcag cctgacctgc    1560

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcaa tgggcagccg    1620

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac    1680

agcaggctaa ccgtggacaa gagcaggtgg caggagggga atgtcttctc atgctccgtg    1740

atgcatgagg ctctgcacaa ccactacaca cagaagagcc tctccctgtc tctgggtaaa    1800

tgagtgccag ggccggcaag cccccgctcc ccgggctctc ggggtcgcgc gaggatgctt    1860

ggcacgtacc ccgtctacat acttcccagg cacccagcat ggaaataaag cacccaccac    1920

tgccctgggc ccctgtgaga ctgtgatggt tctttccacg ggtcaggccg agtctgaggc    1980

ctgagtgaca tgagggaggc agagcgggtc ccactgtccc cacactgg                 2028


<210> 177
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> 1205, light chain VL

<400> 177
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Val Pro His Tyr Pro 
                85                  90                  95      
Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 178
<211> 324
<212> DNA
<213> Homo sapiens


<220> 
<223> 1205, light chain VL

<400> 178
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tctgttccgc actacccgtt cacttttggc     300

caggggacca agctggagat caaa                                            324


<210> 179
<211> 123
<212> PRT
<213> Homo sapiens


<220> 
<223> 1204, heavy chain VH

<400> 179
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Gly Ser Tyr Tyr Gly Tyr Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr Phe Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 180
<211> 369
<212> DNA
<213> Homo sapiens


<220> 
<223> 1204, heavy chain VH

<400> 180
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt caccttttct tcttactaca tgggttgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt attggttctt actacggtta cacaggttat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcgcttac     300

tacgactaca actactacta cgcttacttt gactattggg gccagggaac cctggtcacc     360

gtctcctca                                                             369


<210> 181
<211> 116
<212> PRT
<213> Homo sapiens


<220> 
<223> 1214 (VH)

<400> 181
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Gly Ser Gly Gly Gly Tyr Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Gly His Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 182
<211> 348
<212> DNA
<213> Homo sapiens


<220> 
<223> 1214 (VH)

<400> 182
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatct attggttctg gtggtggtta cacaggttat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcgttggt     300

catccgtttg actattgggg ccagggaacc ctggtcaccg tctcctca                  348


<210> 183
<211> 106
<212> PRT
<213> Homo sapiens


<220> 
<223> 1215 (VL)

<400> 183
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Ala Tyr Pro His Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 184
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> 1215 (VL)

<400> 184
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag gacgcttacc cgcacacttt tggccagggg     300

accaagctgg agatcaaa                                                   318


<210> 185
<211> 121
<212> PRT
<213> Homo sapiens


<220> 
<223> 1618 (VH)

<400> 185
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Gly 
            20                  25                  30          
Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Ser Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Ser Tyr Tyr Gly Ser Tyr Tyr Ser Ile Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 186
<211> 363
<212> DNA
<213> Homo sapiens


<220> 
<223> 1618 (VH)

<400> 186
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt caccttttct tacggttcta tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatct atttcttctg gttctggttc tacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctcttct     300

tactacggtt cttactactc tattgactat tggggccagg gaaccctggt caccgtctcc     360

tca                                                                   363


<210> 187
<211> 107
<212> PRT
<213> Homo sapiens


<220> 
<223> 1619 (VL)

<400> 187
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Asn Leu Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 188
<211> 321
<212> DNA
<213> Homo sapiens


<220> 
<223> 1619 (VL)

<400> 188
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tactacgaca acctgcccac ttttggccag     300

gggaccaagc tggagatcaa a                                               321


<210> 189
<211> 117
<212> PRT
<213> Homo sapiens


<220> 
<223> 1620 (VH)

<400> 189
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Ser Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Val Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 190
<211> 351
<212> DNA
<213> Homo sapiens


<220> 
<223> 1620 (VH)

<400> 190
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt caccttttct ggttactaca tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcaggt atttcttctt ctggttctta cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctctgtt     300

ggtccgtact ttgactattg gggccaggga accctggtca ccgtctcctc a              351


<210> 191
<211> 106
<212> PRT
<213> Homo sapiens


<220> 
<223> 1621 (VL)

<400> 191
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Gly Pro Tyr Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 192
<211> 318
<212> DNA
<213> Homo sapiens


<220> 
<223> 1621 (VL)

<400> 192
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtgttggtc cgtacacttt tggccagggg     300

accaagctgg agatcaaa                                                   318


<210> 193
<211> 117
<212> PRT
<213> Homo sapiens


<220> 
<223> 1626 (VH)

<400> 193
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          
Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Gly Gly Tyr Tyr Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Tyr Tyr Gly Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 194
<211> 351
<212> DNA
<213> Homo sapiens


<220> 
<223> 1626 (VH)

<400> 194
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttggt ggttactcta tgtactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcatct attggtggtt actactactc tacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctcttac     300

tacggttcta ttgactattg gggccaggga accctggtca ccgtctcctc a              351


<210> 195
<211> 108
<212> PRT
<213> Homo sapiens


<220> 
<223> 1627 (VL)

<400> 195
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Thr Gly Tyr Gly Pro 
                85                  90                  95      
Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 196
<211> 324
<212> DNA
<213> Homo sapiens


<220> 
<223> 1627 (VL)

<400> 196
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtactggtt acggtccgct cacttttggc     300

caggggacca agctggagat caaa                                            324


<210> 197
<211> 1376
<212> DNA
<213> Artificial Sequence


<220> 
<223> 1761 = 1205 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040 inclusive intron sequence

<400> 197
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tctgttccgc actacccgtt cacttttggc     300

caggggacca agctggagat caaacgtgag tcgtacgcta gcaagcttga tatcgaattc     360

taaactctga gggggtcgga tgacgtggcc attctttgcc taaagcattg agtttactgc     420

aaggtcagaa aagcatgcaa agccctcaga atggctgcaa agagctccaa caaaacaatt     480

tagaacttta ttaaggaata gggggaagct aggaagaaac tcaaaacatc aagattttaa     540

atacgcttct tggtctcctt gctataatta tctgggataa gcatgctgtt ttctgtctgt     600

ccctaacatg ccctgtgatt atccgcaaac aacacaccca agggcagaac tttgttactt     660

aaacaccatc ctgtttgctt ctttcctcag gaactgtggc tgcaccatct gtcttcatct     720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata     780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta     840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca     900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     960

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt agcggaggag    1020

gaggaagcgg aggaggagga agcgcccccc tcaaaatcca agcgtacttc aacgaaactg    1080

cagacttacc gtgtcagttt gccaattcgc agaatctgag cctgagcgaa ctggtggttt    1140

tctggcagga tcaggagaac ctggttctga acgaagtcta tctgggcaaa gagcggttcg    1200

acagcgtgga cagcaagtat atgggccgca ccagctttga tagcgacagc tggaccctgc    1260

gtctgcacaa tctgcaaatc aaagataagg gtaggtacca gtgcattatc caccataaga    1320

agccgacggg tatgattaat attcaccaaa tgaactccga gttgtctgtc ctggcg        1376


<210> 198
<211> 337
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1761 =1205 light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 198
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Val Pro His Tyr Pro 
                85                  90                  95      
Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 
Gly Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp 
225                 230                 235                 240 
Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu 
                245                 250                 255     
Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr 
            260                 265                 270         
Leu Gly Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg 
        275                 280                 285             
Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln 
    290                 295                 300                 
Ile Lys Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro 
305                 310                 315                 320 
Thr Gly Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                325                 330                 335     
Ala 
    

<210> 199
<211> 1370
<212> DNA
<213> Artificial Sequence


<220> 
<223> 1763 = 1215 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 199
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag gacgcttacc cgcacacttt tggccagggg     300

accaagctgg agatcaaacg tgagtcgtac gctagcaagc ttgatatcga attctaaact     360

ctgagggggt cggatgacgt ggccattctt tgcctaaagc attgagttta ctgcaaggtc     420

agaaaagcat gcaaagccct cagaatggct gcaaagagct ccaacaaaac aatttagaac     480

tttattaagg aataggggga agctaggaag aaactcaaaa catcaagatt ttaaatacgc     540

ttcttggtct ccttgctata attatctggg ataagcatgc tgttttctgt ctgtccctaa     600

catgccctgt gattatccgc aaacaacaca cccaagggca gaactttgtt acttaaacac     660

catcctgttt gcttctttcc tcaggaactg tggctgcacc atctgtcttc atcttcccgc     720

catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct     780

atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc     840

aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga     900

cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc acccatcagg     960

gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtagcgga ggaggaggaa    1020

gcggaggagg aggaagcgcc cccctcaaaa tccaagcgta cttcaacgaa actgcagact    1080

taccgtgtca gtttgccaat tcgcagaatc tgagcctgag cgaactggtg gttttctggc    1140

aggatcagga gaacctggtt ctgaacgaag tctatctggg caaagagcgg ttcgacagcg    1200

tggacagcaa gtatatgggc cgcaccagct ttgatagcga cagctggacc ctgcgtctgc    1260

acaatctgca aatcaaagat aagggtaggt accagtgcat tatccaccat aagaagccga    1320

cgggtatgat taatattcac caaatgaact ccgagttgtc tgtcctggcg               1370


<210> 200
<211> 335
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1763 = 1215 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 200
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Ala Tyr Pro His Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
225                 230                 235                 240 
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
                245                 250                 255     
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
            260                 265                 270         
Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
        275                 280                 285             
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
    290                 295                 300                 
Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
305                 310                 315                 320 
Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
                325                 330                 335 

<210> 201
<211> 1373
<212> DNA
<213> Artificial Sequence


<220> 
<223> 1765 = 1619 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 201
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag tactacgaca acctgcccac ttttggccag     300

gggaccaagc tggagatcaa acgtgagtcg tacgctagca agcttgatat cgaattctaa     360

actctgaggg ggtcggatga cgtggccatt ctttgcctaa agcattgagt ttactgcaag     420

gtcagaaaag catgcaaagc cctcagaatg gctgcaaaga gctccaacaa aacaatttag     480

aactttatta aggaataggg ggaagctagg aagaaactca aaacatcaag attttaaata     540

cgcttcttgg tctccttgct ataattatct gggataagca tgctgttttc tgtctgtccc     600

taacatgccc tgtgattatc cgcaaacaac acacccaagg gcagaacttt gttacttaaa     660

caccatcctg tttgcttctt tcctcaggaa ctgtggctgc accatctgtc ttcatcttcc     720

cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact     780

tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact     840

cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc     900

tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc     960

agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtagc ggaggaggag    1020

gaagcggagg aggaggaagc gcccccctca aaatccaagc gtacttcaac gaaactgcag    1080

acttaccgtg tcagtttgcc aattcgcaga atctgagcct gagcgaactg gtggttttct    1140

ggcaggatca ggagaacctg gttctgaacg aagtctatct gggcaaagag cggttcgaca    1200

gcgtggacag caagtatatg ggccgcacca gctttgatag cgacagctgg accctgcgtc    1260

tgcacaatct gcaaatcaaa gataagggta ggtaccagtg cattatccac cataagaagc    1320

cgacgggtat gattaatatt caccaaatga actccgagtt gtctgtcctg gcg           1373


<210> 202
<211> 336
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1765 = 1619 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 202
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Asn Leu Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 
Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
225                 230                 235                 240 
Pro Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val 
                245                 250                 255     
Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
            260                 265                 270         
Gly Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr 
        275                 280                 285             
Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
    290                 295                 300                 
Lys Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
305                 310                 315                 320 
Gly Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
                325                 330                 335     



<210> 203
<211> 1370
<212> DNA
<213> Artificial Sequence


<220> 
<223> 1767 = 1621 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 203
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtgttggtc cgtacacttt tggccagggg     300

accaagctgg agatcaaacg tgagtcgtac gctagcaagc ttgatatcga attctaaact     360

ctgagggggt cggatgacgt ggccattctt tgcctaaagc attgagttta ctgcaaggtc     420

agaaaagcat gcaaagccct cagaatggct gcaaagagct ccaacaaaac aatttagaac     480

tttattaagg aataggggga agctaggaag aaactcaaaa catcaagatt ttaaatacgc     540

ttcttggtct ccttgctata attatctggg ataagcatgc tgttttctgt ctgtccctaa     600

catgccctgt gattatccgc aaacaacaca cccaagggca gaactttgtt acttaaacac     660

catcctgttt gcttctttcc tcaggaactg tggctgcacc atctgtcttc atcttcccgc     720

catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct     780

atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc     840

aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga     900

cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc acccatcagg     960

gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtagcgga ggaggaggaa    1020

gcggaggagg aggaagcgcc cccctcaaaa tccaagcgta cttcaacgaa actgcagact    1080

taccgtgtca gtttgccaat tcgcagaatc tgagcctgag cgaactggtg gttttctggc    1140

aggatcagga gaacctggtt ctgaacgaag tctatctggg caaagagcgg ttcgacagcg    1200

tggacagcaa gtatatgggc cgcaccagct ttgatagcga cagctggacc ctgcgtctgc    1260

acaatctgca aatcaaagat aagggtaggt accagtgcat tatccaccat aagaagccga    1320

cgggtatgat taatattcac caaatgaact ccgagttgtc tgtcctggcg               1370


<210> 204
<211> 335
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1767 = 1621 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 204
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Gly Pro Tyr Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
225                 230                 235                 240 
Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
                245                 250                 255     
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
            260                 265                 270         
Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg Thr Ser 
        275                 280                 285             
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
    290                 295                 300                 
Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
305                 310                 315                 320 
Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
                325                 330                 335 

<210> 205
<211> 1376
<212> DNA
<213> Artificial Sequence


<220> 
<223> 1769= 1627 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 205
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc      60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca     180

cgtttcagtg gcagtggaag cgggacagat ttcactctca ccatcagcag tctgcaacct     240

gaagattttg caacttatta ctgtcaacag ggtactggtt acggtccgct cacttttggc     300

caggggacca agctggagat caaacgtgag tcgtacgcta gcaagcttga tatcgaattc     360

taaactctga gggggtcgga tgacgtggcc attctttgcc taaagcattg agtttactgc     420

aaggtcagaa aagcatgcaa agccctcaga atggctgcaa agagctccaa caaaacaatt     480

tagaacttta ttaaggaata gggggaagct aggaagaaac tcaaaacatc aagattttaa     540

atacgcttct tggtctcctt gctataatta tctgggataa gcatgctgtt ttctgtctgt     600

ccctaacatg ccctgtgatt atccgcaaac aacacaccca agggcagaac tttgttactt     660

aaacaccatc ctgtttgctt ctttcctcag gaactgtggc tgcaccatct gtcttcatct     720

tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata     780

acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta     840

actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca     900

ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc     960

atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt agcggaggag    1020

gaggaagcgg aggaggagga agcgcccccc tcaaaatcca agcgtacttc aacgaaactg    1080

cagacttacc gtgtcagttt gccaattcgc agaatctgag cctgagcgaa ctggtggttt    1140

tctggcagga tcaggagaac ctggttctga acgaagtcta tctgggcaaa gagcggttcg    1200

acagcgtgga cagcaagtat atgggccgca ccagctttga tagcgacagc tggaccctgc    1260

gtctgcacaa tctgcaaatc aaagataagg gtaggtacca gtgcattatc caccataaga    1320

agccgacggg tatgattaat attcaccaaa tgaactccga gttgtctgtc ctggcg        1376


<210> 206
<211> 337
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1769 = 1627 Light chain VL, with constant kappa sequence, linker
      and CD86 mutant 1040

<400> 206
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Thr Gly Tyr Gly Pro 
                85                  90                  95      
Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 
Gly Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp 
225                 230                 235                 240 
Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu 
                245                 250                 255     
Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr 
            260                 265                 270         
Leu Gly Lys Glu Arg Phe Asp Ser Val Asp Ser Lys Tyr Met Gly Arg 
        275                 280                 285             
Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln 
    290                 295                 300                 
Ile Lys Asp Lys Gly Arg Tyr Gln Cys Ile Ile His His Lys Lys Pro 
305                 310                 315                 320 
Thr Gly Met Ile Asn Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                325                 330                 335     
Ala 
    

<210> 207
<211> 8
<212> PRT
<213> Homo sapiens


<400> 207
Gly Phe Thr Phe Ser Ser Tyr Tyr 
1               5               

<210> 208
<211> 8
<212> PRT
<213> Homo sapiens


<400> 208
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 209
<211> 8
<212> PRT
<213> Homo sapiens


<400> 209
Gly Phe Thr Phe Ser Tyr Gly Ser 
1               5               

<210> 210
<211> 8
<212> PRT
<213> Homo sapiens


<400> 210
Gly Phe Thr Phe Ser Gly Tyr Tyr 
1               5               

<210> 211
<211> 8
<212> PRT
<213> Homo sapiens


<400> 211
Gly Phe Thr Phe Gly Gly Tyr Ser 
1               5               

<210> 212
<211> 8
<212> PRT
<213> Homo sapiens


<400> 212
Ile Gly Ser Tyr Tyr Gly Tyr Thr 
1               5               

<210> 213
<211> 8
<212> PRT
<213> Homo sapiens


<400> 213
Ile Gly Ser Gly Gly Gly Tyr Thr 
1               5               

<210> 214
<211> 8
<212> PRT
<213> Homo sapiens


<400> 214
Ile Ser Ser Gly Ser Gly Ser Thr 
1               5               

<210> 215
<211> 8
<212> PRT
<213> Homo sapiens


<400> 215
Ile Ser Ser Ser Gly Ser Tyr Thr 
1               5               

<210> 216
<211> 8
<212> PRT
<213> Homo sapiens


<400> 216
Ile Gly Gly Tyr Tyr Tyr Ser Thr 
1               5               

<210> 217
<211> 16
<212> PRT
<213> Homo sapiens


<400> 217
Ala Arg Ala Tyr Tyr Asp Tyr Asn Tyr Tyr Tyr Ala Tyr Phe Asp Tyr 
1               5                   10                  15      



<210> 218
<211> 9
<212> PRT
<213> Homo sapiens


<400> 218
Ala Arg Val Gly His Pro Phe Asp Tyr 
1               5                   

<210> 219
<211> 14
<212> PRT
<213> Homo sapiens


<400> 219
Ala Arg Ser Ser Tyr Tyr Gly Ser Tyr Tyr Ser Ile Asp Tyr 
1               5                   10                  

<210> 220
<211> 10
<212> PRT
<213> Homo sapiens


<400> 220
Ala Arg Ser Val Gly Pro Tyr Phe Asp Tyr 
1               5                   10  

<210> 221
<211> 10
<212> PRT
<213> Homo sapiens


<400> 221
Ala Arg Ser Tyr Tyr Gly Ser Ile Asp Tyr 
1               5                   10  

<210> 222
<211> 10
<212> PRT
<213> Homo sapiens


<400> 222
Gln Gln Ser Val Pro His Tyr Pro Phe Thr 
1               5                   10  

<210> 223
<211> 8
<212> PRT
<213> Homo sapiens


<400> 223
Gln Gln Asp Ala Tyr Pro His Thr 
1               5               

<210> 224
<211> 9
<212> PRT
<213> Homo sapiens


<400> 224
Gln Gln Tyr Tyr Asp Asn Leu Pro Thr 
1               5                   

<210> 225
<211> 8
<212> PRT
<213> Homo sapiens


<400> 225
Gln Gln Gly Val Gly Pro Tyr Thr 
1               5               

<210> 226
<211> 10
<212> PRT
<213> Homo sapiens


<400> 226
Gln Gln Gly Thr Gly Tyr Gly Pro Leu Thr 
1               5                   10  

