                         SEQUENCE LISTING

<110>  U3 Pharma GmbH
 
<120>  Combination of FGFR4-Inhibitor and Bile Acid Sequestrant

<130>  59300P EP

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-1-VH CDRH1

<400>  1

Arg Asn Tyr Met Ser 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-2-VH CDRH1

<400>  2

Lys Ala Trp Met Ser 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-3-VH, U4-7-VH and U4-9-VH CDRH1

<400>  3

Asp Tyr Tyr Met Ser 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-4-VH and U4-8-VH CDRH1

<400>  4

Ser Asn Tyr Met Ser 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-5-VH CDRH1

<400>  5

Ser Asn Tyr Met Asn 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-6-VH CDRH1

<400>  6

Asp Tyr Tyr Met Asn 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-1-VH, U4-2-VH and U4-7-VH CDRH2

<400>  7

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-3-VH and U4-9-VH CDRH2

<400>  8

Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-4-VH CDRH2

<400>  9

Leu Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-5-VH CDRH2

<400>  10

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-8-VH CDRH2

<400>  11

Ser Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-6-VH CDRH2

<400>  12

Ala Ile Gly Gly Ser Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-1-VH CDRH3

<400>  13

Val Thr Ser Pro Gly Ala Phe Asp Ile 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-2-VH CDRH3

<400>  14

Leu Tyr Ser Tyr Gly Asp Phe Asp His 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-3-VH and U4-9-VH CDRH3

<400>  15

Leu Thr Ala Tyr Gly His Val Asp Ser 
1               5                   


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-4-VH CDRH3

<400>  16

Asn Thr Ala Gly Phe Gly Tyr Phe Asp Leu 
1               5                   10  


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-5-VH CDRH3

<400>  17

Lys Ser Arg Asp Phe Trp Arg Gly Pro Phe Asp Tyr 
1               5                   10          


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-8-VH CDRH3

<400>  18

Met Thr Val Phe Gly Ala Ala Thr Leu 
1               5                   


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-6-VH CDRH3

<400>  19

Gly Gly Ser Tyr Phe Gly Tyr 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-7-VH CDRH3

<400>  20

Leu Ala Thr Tyr Gly Pro Phe Asp Asp 
1               5                   


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-1-VL CDRL1

<400>  21

Ser Gly Gly Thr Ser Asn Ile Gly Thr Asn Thr Val Asn 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-2-VL, U4-4-VL, U4-5-VL, U4-6-VL and U4-8-VL CDRL1

<400>  22

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-3-VL CDRL1

<400>  23

Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Thr Val Asn 
1               5                   10              


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-1-VL, U4-2-VL, U4-4-VL, U4-5-VL and U4-8-VL CDRL2

<400>  24

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-3-VL CDRL2

<400>  25

Arg Asn Tyr Gln Arg Pro Ser 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-6-VL CDRL2

<400>  26

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-7-VL and U4-9-VL CDRL2

<400>  27

Arg Asn Asn Arg Arg Pro Ser 
1               5           


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-1-VL CDRL3

<400>  28

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Tyr Val Val 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-2-VL CDRL3

<400>  29

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Ala Val Val 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-3-VL CDRL3

<400>  30

Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro His Val Val 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-4-VL CDRL3

<400>  31

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Leu Val Val 
1               5                   10              


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-5-VL CDRL3

<400>  32

Ser Thr Trp Asp Asp Ser Leu Arg Gly Trp Val 
1               5                   10      


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-8-VL CDRL3

<400>  33

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Tyr Trp Val 
1               5                   10              


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-6-VL CDRL3

<400>  34

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-7-VL and U4-9-VL CDRL3

<400>  35

Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Asn Val Val 
1               5                   10              


<210>  36
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-1-VH

<400>  36
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agaaactaca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagttacc      300

tcaccagggg cttttgatat ctggggccaa ggtaccctgg tcaccgtgag ctca            354


<210>  37
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-2-VH

<400>  37
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aaagcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagattatac      300

agctatggtg actttgacca ctggggccaa ggtaccctgg tcaccgtgag ctcagcctcc      360

accaagggcc caagcgtctt ccccctggca ccctcctcc                             399


<210>  38
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-3-VH and U4-9-VH

<400>  38
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta gtggtggtag tacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc cagactcacc      300

gcctatggcc acgtagactc ctggggccaa ggtaccctgg tcaccgtgag ctcagcctcc      360

accaagggcc caagcgtctt ccccctggca ccctcctcc                             399


<210>  39
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-4-VH

<400>  39
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactt attagtggta gtggtggtag cacatactac      180

gcagactccg tgcagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagaaatacg      300

gctggttttg ggtacttcga tctctggggc caaggtaccc tggtcaccgt gagctcagcc      360

tccaccaagg gcccaagcgt cttccccctg gcaccctcct cc                         402


<210>  40
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-5-VH

<400>  40
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agcaactaca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgt gacaaagtct      300

cgagattttt ggcggggtcc ctttgactac tggggccaag gtaccctggt caccgtgagc      360

tcagcctcca ccaagggccc aagcgtcttc cccctggcac cctcctcc                   408


<210>  41
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-8-VH

<400>  41
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attagtggta gtggtggtcg cacatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagaatgacg      300

gtctttggag cggcaacgct ctggggccaa ggtaccctgg tcaccgtgag ctcagcctcc      360

accaagggcc caagcgtctt ccccctggca ccctcctcc                             399


<210>  42
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-6-VH

<400>  42
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgaactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtctcagct attggtggta gtggtgatag aacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc tctcggtggg      300

agctacttcg gctactgggg ccaaggtacc ctggtcaccg tgagctcagc ctccaccaag      360

ggcccaagcg tcttccccct ggcaccctcc tcc                                   393


<210>  43
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-7-VH

<400>  43
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctgggt ccgccaggct      120

cccgggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gaccctggcc      300

acctacggac catttgacga ctggggccaa ggtaccctgg tcaccgtgag ctcagcctcc      360

accaagggcc caagcgtctt ccccctggca ccctcctcc                             399


<210>  44
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-1-VL

<400>  44
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaggcacctc caacatcgga actaatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcatcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccctat      300

gtggtattcg gcggaggaac caagctgacg gtcctaggtc agcct                      345


<210>  45
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-2-VL

<400>  45
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat cggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtcccgct      300

gtggtattcg gcggaggaac caagctgacg gtcctaggtc agcct                      345


<210>  46
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-3-VL

<400>  46
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga actaatactg tgaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaattatc agagaccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg atagcctgag tggtccacat      300

gtggtattcg gcggaggaac caagctgacg gtcctaggtc agcct                      345


<210>  47
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-4-VL

<400>  47
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccccta      300

gtggtattcg gcggaggaac caagctgacg gtcctaggtc agcct                      345


<210>  48
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-5-VL

<400>  48
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgttca acgtgggatg acagcctgag aggttgggtg      300

ttcggcggag gaaccaagct gacggtccta ggtcagcct                             339


<210>  49
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-8-VL

<400>  49
cagtctgtgc tgactcagcc accctcagca tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccctat      300

tgggtgttcg gcggaggaac caagctgacg gtcctaggtc agcct                      345


<210>  50
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-6-VL

<400>  50
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat tatgatgatc tgctgccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccggtg      300

ttcggcggag gaaccaagct gacggtccta ggtcagcct                             339


<210>  51
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U4-7-VL and U4-9-VL

<400>  51
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg tacactggta tcagcagctc      120

ccaggaacgg cccccaaact cctcatctat agaaataatc ggcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtccgaat      300

gtggtattcg gcggaggaac caagctgacg gtcctaggtc agcct                      345


<210>  52
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-1-VH

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Thr Ser Pro Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  53
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-2-VH

<400>  53

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Ser Tyr Gly Asp Phe Asp His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser 
    130             


<210>  54
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-3-VH and U4-9-VH

<400>  54

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Ala Tyr Gly His Val Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser 
    130             


<210>  55
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-4-VH

<400>  55

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Thr Ala Gly Phe Gly Tyr Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser 
    130                 


<210>  56
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-5-VH

<400>  56

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Lys Ser Arg Asp Phe Trp Arg Gly Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135     


<210>  57
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-8-VH

<400>  57

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Thr Val Phe Gly Ala Ala Thr Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser 
    130             


<210>  58
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-6-VH

<400>  58

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Gly Ser Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Gly Gly Ser Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser 
    130     


<210>  59
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-7-VH

<400>  59

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Ala Thr Tyr Gly Pro Phe Asp Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser 
    130             


<210>  60
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-1-VL

<400>  60

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Thr Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ser Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro 
        115 


<210>  61
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-2-VL

<400>  61

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro 
        115 


<210>  62
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-3-VL

<400>  62

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro 
        115 


<210>  63
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-4-VL

<400>  63

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Leu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro 
        115 


<210>  64
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-5-VL

<400>  64

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro 
    


<210>  65
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-8-VL

<400>  65

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Tyr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro 
        115 


<210>  66
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-6-VL

<400>  66

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro 
    


<210>  67
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-7-VL and U4-9-VL

<400>  67

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro 
        115 


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  U4-7 and U4-9 CDRL1

<400>  68

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val His 
1               5                   10              


